june 3 & 4, 2011 philadelphia pa, usa britton chance: life, times, & legacy symposium and...
TRANSCRIPT
June 3 & 4, 2011Philadelphia PA, USA
Britton Chance: Life, Times, & Legacy
Symposium and Workshop
Translational Research in
Near Infrared Based Functional Brain Imaging
Banu Onaral, PhDH.H. Sun Professor and Director
School of Biomedical Engineering, Science & Health Systems
Drexel University, Philadelphia, PA [email protected]
Realizing BC’s dream……Move discoveries to practice
>> Portable Near-Infrared Technology for Detection of Hematoma
>> Portable Near-Infrared Technology for Brain Activity Monitor
BC’s Dream Team
Adrian Curtin
Shoko Nioka
Outline• Optical Brain Imaging (fNIR)
– Physiological and Physical Principles– Chance-Drexel fNIR Technology Evolution
• Applications– Regional and Global Collaborations– Human Performance, Brain Integrated Simulation…
• Translational Research– Clinical Solutions
– Conclusion
Functional Near-Infrared Monitor [fNIR]>> Cortical activation-related to hemodynamic changes in natural
environments and diverse field conditions
Optical Brain ImagingNear Infrared Based Platform
Physiological Principles of fNIR Neural Activity & Hemodynamic Response
Neurons consume energy (glucose) when activated
Oxygen is required to metabolize the glucose
As clusters of neurons are activated, there is an increased need for oxygen in that area
Oxygen is transported to neural tissue via oxy-hemoglobin in the blood
Oxy-Hb and deoxy-Hb are correlates of brain activity through oxygen consumption by neurons
The oxygen exchange occurs in the capillary beds
As oxy-hemoglobin gives up oxygen to the neural tissue, it is transformed into deoxygenated hemoglobin
David J. Heeger & David Ress. (2002)What does fMRI tell us about neuronal activity? Nature Reviews Neuroscience 3, 142-151
Source
Detector
Physical Principles of fNIR I Photon Migration in Tissue
H Obrig , R Wenzel, M Kohl, S Horst, P Wobst, J Steinbrink, F Thomas, A Villringer. Near-infrared spectroscopy: does it function in functional activation studies of the adult brain? International Journal of Psychophysiology 35(2-3):125-142, 2000
Photons that enter the tissue undergo two types of interaction:
Scattering(cell membranes)
Absorption(Hb, HbO2, water)
Physical Principles of fNIR II
Near IR
Optical Window in Tissue
.G
Stimuli Presentation
Initial Dip
PeakOxygenation
Post stimulusundershoot
HbHbHbOHbO CCCCeeBloodVolumBloodVolum 22 HbHbHbOHbO CCCCeeBloodVolumBloodVolum 22
HbHbHbOHbO CCCCnnOxygenatioOxygenatio 22 HbHbHbOHbO CCCCnnOxygenatioOxygenatio 22
LLCCCCIIII
ODOD HBOHBOHBOHBOHBHBHBHBBB ))((loglog
22221010 LLCCCCIIII
ODOD HBOHBOHBOHBOHBHBHBHBBB ))((loglog
22221010
LLCCCC HBOHBOHBOHBOHBHBHBHBIIII))((
0022221010
LLCCCC HBOHBOHBOHBOHBHBHBHBIIII))((
0022221010
ModifiedBeer-Lambert Law
.G Io I
Early versions of continuous wave (CW) system
Current version of CW system
Chance-Drexel fNIR Technology Evolution
fNIR System 100fNIR Devices, LLC
RunMan, CogniscopeNIM, Inc
Early versions of wireless system (PDA based)
Wireless pediatric system (ZigBee)
Adhesive stick-on wireless system
Chance-Drexel fNIR Wireless Technology Evolution
Sensors
Programmable/Transmitter IC
Embedded in a head band with batteries
Wireless Link
data
University of Maryland (Dr. José L. Contreras-Vidal)
University of Pittsburgh (Dr. Joseph Ricker)
Albert Einstein College of Medicine (Dr. Roee Holtzer)
Italy – Polytechnic University of Milan (Dr. Sergio Cerutti)
Spain – University of Seville (Dr. Jose Leon-Carrion) – Hospital Nacional de Paraplejicos Toledo (Dr. Guglielmo Foffani)
Israel – Haifa University (Dr. Zvia Breznitz) Hebrew University (Dr. Esther Shohami)
Turkey – Middle East Technical University (Dr. Veysi Isler) – Dokuz Eylul University (Dr. Murat Ozgeren )
China – Wuhan National Laboratory for Optoelectronics (Dr. Shoko Nioka) Med-X, Shanghai Jiao Tong University Shanghai Mental Health Center
United Kingdom – The Defence Science and Technology Laboratory (DSTL)
Japan – Bukkyo University (Dr. Yasufumi Kuroda)
Global Collaborations
in Functional Optical Brain Imaging
Human Performance Assessment…
Optical Brain Imaging
Human Performance Assessment
Defense Advanced Research Projects Agency (DARPA) Augmented Cognition Program
©
Brain integrated Simulation…“Brain in the Loop”
Optical Brain Imaging
Simulation & Multimedia ApplicationBrain Activity Monitoring in VR Environment
Clinical Solutions…
Optical Brain Imaging
…Solutions
Traumatic Brain Injury>> Portable Near-Infrared Technology for
Detection of Hematoma
Near Infrared Based Platform
Hasan Ayaz, PhDBIOMED
Banu Onaral, PhDBIOMED
Baruch Ben Dor, PhDBIOMED
Optical Brain Imaging…
MeltemIzzetoglu, PhDBIOMED
Kambiz Pourrezaei, PhDBIOMED
InfrascannerTM
Life Saving…
…Solutions
Pediatric Monitoring>> Functional Optical Brain Imaging Sensor
Near Infrared Based Platform
MeltemIzzetoglu, PhDBIOMED
Banu Onaral, PhDBIOMED
Harel Rosen, MDNeonatology, CHOP
Arye Rosen, PhDBIOMED
Kambiz Pourrezaei, PhDBIOMED
fNIR Sensor for Neonates
>> Assessment of Cognitive Impairment and Recovery Following Traumatic Brain injury (TBI)
Life Saving…
…Solutions
NeurorehabilitationNear Infrared Based Platform
HealthySubject
Banu Onaral, PhDBIOMED
TBIPatient
Maria Schultheis, PhDPsychology, CoAS
Anna C. Merzagora, PhDBIOMED
Life Saving…
…Solutions
Near Infrared Based Platform
fNIRAwareness
Monitor
Banu Onaral, PhDBIOMED
George Mychaskiw, MD Anesthesiology, COM
Patient wearing fNIR Sensor
James Reynolds, MD, COM
Kurtulus Izzetoglu, Ph.DBIOMED
>> Portable fNIR system for monitoring depth of anesthesia to prevent awareness during surgery
Depth of Anesthesia
Kambiz Pourrezaei, PhDBIOMED
Meltemİzzetoğlu, Ph.D BIOMED
Optical Brain Imaging…
…Solutions
Cognitive AgingNear Infrared Based Platform
Banu Onaral, PhDBIOMED
KurtulusIzzetogluBIOMED
Roee HoltzerAlbert Einstein CoM
MeltemIzzetoglu, PhDBIOMED
Joe Verghese, MBBS, MSAlbert Einstein, CoM
fNIR
Subject wearing fNIR during attention task
Brain activity monitor while walking
>> Assessment of cognitive functions in natural settings
Optical Brain Imaging…
…Solutions
Autism, Schizophrenia…
Near Infrared Based Platform
Drexel Optical Brain Imaging Team
Scott Bunce, PhDPsychiatry, Penn State University COM
Personality and psychiatric disorders...
Functional Optical Brain Imaging Sensor
Banu Onaral, PhDBIOMED
Kambiz Pourrezaei, PhDBIOMED
Optical Brain Imaging…
…Solutions
ALS, Spinal Cord Injury, ParalysisNear Infrared Based Platform
Terry Heiman-Patterson, MDNeurology, COM
Banu Onaral, PhDBIOMED
Target Patient Population:• Amyotrophic Lateral Sclerosis (ALS)• Spinal Cord Injuries/Paralysis • Cerebral Palsy, Muscular Dystrophy • Brainstem Stroke, and others…
Hasan Ayaz, PhDBIOMED
Patricia Shewokis, PhDNursing, CoNHP
>> Brain Computer Interface (BCI)
WWW.BIOMED.DREXEL.EDU
Banu Onaral3141 Chestnut StreetPhiladelphia, PA 19104Phone: 215-895-2215Fax: 215-895-4983Email: [email protected]
Thank you!
Human Performance Assessment
Safe & Effective
Piloting
Air Traffic Controller
Cognitive Workload Monitor
UAV Ground Operator
Training and Workload Monitor
Pilot
Expertise Development
Monitor
Brain Activity
MonitorCrew can manage & maintain high levels of cognitive information processing
Portable brain imaging technology can “bring more of brain on task”*
S a f e & e f f e c t i v e p e r f o r m a n c e
*DARPA: Dylan Schmorrow, Ph.D. LCDR, MSC, US Navy, Program Manager, ITO
Air Traffic Controller
FAA Next Generation Air Transportation System (NextGen) Study
Similar to SESAR (Single European Sky ATM Research) Program
ATC part-task
Communication type: Voice Comm and Data Comm
Workload manipulated by number of aircrafts in the sector: n= 6,12,18
16-channel fNIR sensor
UAV Safe Piloting
Integration of the functional brain monitoring system with training procedures ground control systems
objective measure of expertise level to validate adequate training
real-time monitor of mental workload
safe operation of UAVs…
US Army Medical Research and Materiel Command (USAMRMC) The Telemedicine & Advanced Technology Research Center (TATRC)