k7-biochemistry of blood brain barrier.pptx
TRANSCRIPT
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Biochemistry of BloodBrain Barrier (BBB)Biochemistry of BloodBrain Barrier (BBB)
Dr. Hidayat
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LEARNING O JECTIVE
EARNING O JECTIVE
To explain :
Blood - Brain Barrier
Blood - CSF Transport
CSF - Brain Transport
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BRAINBRAIN
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CEREBRAL VENTRICLECEREBRAL VENTRICLE
4 ventricles in brain (two lateral, third and fourth)
Membrane bound cavities lined with ependymal cells.
Filled with CSF (1mm!" pressure)
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CEREBRO!INAL "L#I$ (C")CEREBRO!INAL "L#I$ (C")
Composition different to plasma
lower protein
hi"her #a$lower %$
&ives protection (mechanical
and chemical)'y circulatin" it echan"es
nutrients and wastes
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Menin"eal Membranes and Cerebrospinal FluidMenin"eal Membranes and Cerebrospinal Fluid
ura mater
*rachnoid mater
+ia mater
hree menin"eal membranes
+rotective function and involved in the production and reabsorption of CSF
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Menin"eal Membranes and CSF- 'rainMenin"eal Membranes and CSF- 'rain
ura mater
Sa"ittal sinus (ural sinus)
*rachnoid mater
Subarachnoid space
+ia mater
wo important cavities (spaces) within the menin"eal membranes
n addition to CSF in ventricles//.
CSF circulates throu"h the subarachnoid space and is reabsorbed into the Sa"ittal
(ural) sinus
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0hat is 'lood 'rain 'arrier 0hat is 'lood 'rain 'arrier
#ot a sin"le barrier but a collection of physical
and physiolo"ical barriers that limit the entry of
compounds into the C#S
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Formed by brain microvascular endothelialcells (B!C"# astrocyte end $eet andpericytes
!ssential $or normal $unction o$ C%S
&e'ulates passa'e o$ molecules in and out
o$ brain to maintain neural environment. &esponsible $or metabolic activities such as
the metabolism o$ -dopa to re'ulate its
concentration in the brain.
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Blood Brain BarrierBlood Brain Barrier
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Brain Ca%illaryBrain Ca%illary
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$ifferences &et'een BEC and normalendothelial cells
$ifferences &et'een BEC and normalendothelial cells
Structural di$$erences: )bsence o$ $enestrations ore extensive ti'ht *unctions (T+"
Functional di$$erences: ,mpermeable to most substances Sparse pinocytic vesicular transport
,ncreased expression o$ transport and carrierproteins: receptor mediated endocytosis %o 'ap *unctions# only ti'ht *unctions imited paracellular and transcellular transport
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Tiht J*nctionTiht J*nction
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olec*l Trans%ort in BBBolec*l Trans%ort in BBB
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olec*l Trans%ort in BBBolec*l Trans%ort in BBB
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olec*l Trans%ort in BBBolec*l Trans%ort in BBB
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CLINICAL CORRELATIONCLINICAL CORRELATION
ernicterus
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CLINICAL CORRELATIONCLINICAL CORRELATION
ar/inson0s Disease
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Terima /asih