kobe medical industry development project · hematopoietic stem cell transplants (bone-marrow...
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Kobe Medical Industry Development ProjectKobe Medical Industry Development Project~For raising the level of medical services of citizens and revitalizing Kobe’s economy~
City of Kobe February 2009
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Kobe AirportKobe Airport
Photo: July 2008 (South view)To To SannomiyaSannomiya
SentanSentan IryoIryoCenter Mae sta.Center Mae sta.
Port Island Minami sta.Port Island Minami sta.
HistoryHistoryOct. 1998: Establishment of
“Kobe Medical Industry Development Project Discussion Group”Chairman – Dr. Hiro’o Imura (then President of Kobe City General Hospital)
Dec. 1999: Budget approved for the establishment of IBRI and RIKEN CDB (Millennium Project)
Feb. 2000: Designated as the Special Earthquake Restoration ProjectAug. 2001: Designated as the Urban Renaissance ProjectApr. 2002: Designated as the Knowledge Cluster Initiative Project Apr. 2003: Deregulation Zone for Advanced Medical Industry createdMar. 2007: Council for Life Science Promotion suggested
TRI
KIMEC
BMA
MEDDEC
BT Center
KIBC
IBRI
RIKENCDB
NextNext--Generation SupercomputerGeneration Supercomputerconstruction siteconstruction site
Kobe City General Hospital Kobe City General Hospital relocation siterelocation site
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Kansai Science City
BackgroundBackground◆ Expansion of the medical-related industry (including welfare)
38 trillion yen (1996) ⇒ 91 trillion yen (2010) [Cabinet meeting decision in 1997]◆ Innovation of advanced medicine technology ⇒ Genome analysis (Personalized medicine),
Induced differentiation of cells (Regenerative medicine)◆ Concentration of life-science related industry in the Kansai area : Close collaboration with industry,
academic and government bodiesAdvantages of Kobe ⇒① Transportation infrastructure ② Living environment ③Collaboration with other
Asian regions ④ Technological capability ⑤Information infrastructure
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Develop as a focal point for R&D of highly advanced medical technologyEstablish a streamlined process from basic research to clinical application and industrialization
Create employment and revitalize local economy
Provide advanced medical servicesand welfare for Kobe citizens
Contribute to improvement of medical technologies in Asian countries
Core functionsCore functions
ObjectiveObjective
GoalsGoalsTranslational
Research
Support for Business
Development
Human Resource
Development
Target areasTarget areas
Construction of a next generation medical system
Medical device Clinical research and trials Regenerative medicine
Bridging the gap between research and practical
application
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2nd StageCompleted in 1994
IBRI： Institute of Biomedical Research and InnovationCDB： RIKEN Center For Developmental BiologyCMIS : RIKEN Center for Molecular Imaging ScienceKIMEC： Kobe KIMEC Center Bldg.TRI： Translational Research Informatics CenterBMA： Business Support Center for Biomedical Research ActivitiesBT： Kobe Univ. Business Incubation Center/
Kobe Biotechnology Research and Human Resource Development CenterKIBC： Kobe International Business CenterHI-DEC： Kobe Healthcare Industry Research CenterKIO： Kobe Incubation OfficeMEDDEC： Kobe Medical Device Development Center
Core FacilitiesCore Facilities
Marine Transportto Kansai International Airport
HIHI--DECDEC
BTBT
BMABMA
Kobe City Kobe City General General HospitalHospital
relocation siterelocation site(2010)(2010)
KIBCKIBC KIOKIO
TRITRI
KIMECKIMEC
MEDDECMEDDEC
IBRIIBRI
CCMISMIS
CDBCDB
Sentan Iryo Center Mae sta.
Port Island Minami sta.
Moving W
alkway
To downtown Sannomiya
To Kobe Airport
NextNext--Generation Generation SupercomputerSupercomputerconstruction siteconstruction site
(partial operation in FY 2010)(partial operation in FY 2010)
Core Facilities
To SannomiyaPort Liner
Kobe CityGeneral Hospital
Port LinerKobe Airport（Opened on Feb. 16th 2006)
Next-Generation SupercomputerConstruction site
Kobe GakuinUniversity(Port Island Campus)
Hyogo College of Medicine
Kobe ShukugawaGakuin UniversityKobe Women’sUniversity
1st StageCompleted in 1981
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Administered by Foundation for Biomedical Research and Innovation (FBRI)
Activities currently pursued:Hematopoietic stem cell transplants(Bone-marrow transplants, cord blood stem cell transplants)Peripheral blood vessels regeneration of the lower extremitiesand cardiovascular regeneration
Dental implants and regeneration of alveolar bone Diagnosis and medical treatment using PET and LinacCerebrovascular therapyChemotherapy for cancerClinical trials of pharmaceuticals and medical devices
Institute of Biomedical Research and InnovationInstitute of Biomedical Research and Innovation
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Research and Development of Medical DevicesResearch and Development of Medical Devices
62 companies consisting of medical device producers and machiner62 companies consisting of medical device producers and machinery/metal firms y/metal firms within the city participate in within the city participate in ““the Medical Devices Development Study Groupthe Medical Devices Development Study Group””
Radiotherapy Machine
LinacPET* Camera
**PET: Positron Emission Tomography
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PET/CT
Put platinum coil into cerebral aneurysm using catheter
Images offered fromDr. Sakai, Neurosurgery Dept., Kobe City General Hospital
X-ray angiographic device
Cyclotron（Manufacturing radioisotope）Administrate radioactive drug into the patients
PET camera（Scan the distribution of radioactivity)
(PET image by FDG of patient with esophageal cancer)
PET image
PET diagnosis
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Support for Clinical TrialsSupport for Clinical Trials
◆ Clinical Trial Model Project: Establishment of the clinic (Oct. 2000)
◆ Community-based Clinical Trials:- Establishment of a network between IBRI and local
medical institutions to treat lifestyle-related diseases- ”Community-based Clinical Trial Discussion Group”
(Dec. 2000-Jul. 2001)- Signing of Basic Agreement (Mar. 2002)- Co-hosting seminars for community-based clinical trial
with Kobe Doctors Association (Nov. 2002-)
◆ Training for Clinical Research Coordinator:Courses for the non-experienced and the experienced
0
200
400
600
800
1000
1200
1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998year
Phase 1
Phase 2,3
Suspension
Number of Clinical Trials
Allergy Group
High Blood Pressure Group
Diabetes GroupHospitals &
ClinicsHospitals &
ClinicsHospitals &
Clinics
Community-based Clinical Trials
Kobe CityGeneral Hospital
IBRI
Support/ CRCClinical Trial
Review Board
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Retina
Blood vessel
Pancreas
Liver
Intestine
Stomach
Breast
Cardiac muscle
LungTrachea
Esophagus
Hair
Central nerve
Under investigation
Practicaluse
Picture of mouse cellPicture of
human cell
Major organ and tissue under regenerative research
Translational Research for Regenerative MedicineTranslational Research for Regenerative Medicine~Realizing cell and tissue Therapies~~Realizing cell and tissue Therapies~
◆ Joint promotion of regenerative medicine with regional organizations
◆ Development of comprehensive technological infrastructure for regenerative medicine
◆ Research and development (R&D) of cell and tissue processing technology
◆ Clinical Research & Trials for Regenerative Medicine
Major Projects:• Leukemia treatment using cultivated umbilical cord blood• Regeneration of skin, cartilage and bone• Regeneration of nerve cells, pancreas cells, blood vessels etc.
Peripheral nerves
Cartilage
Bone
Skin
Cornea
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Regeneration ofRegeneration ofalveolar bone and alveolar bone and periodontiumperiodontium
Before After
Flank Bone
Mesenchymalstem cell
Extract bone marrow
PRP (Platelet-rich Plasma) extracted from self blood
Injectable gel
Treatment of ischemic limbTreatment of ischemic limb
Osteoblastdifferentiation
Angiogenesis
Transplant EPC(Endothelial Progenitor Cell) into muscle
Ischemiclimb
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Research Research Building CBuilding C
Research Research Building ABuilding A
Research Research Building BBuilding BAnimalAnimal
FacilityFacility
ES Cell (mouse)
zebra fish
Planarian
RIKEN Center for Developmental Biology(CDB)RIKEN Center for Developmental Biology(CDB)A worldA world--class center in the field of embryology and stem cell researchclass center in the field of embryology and stem cell research
Research groupsDirector: Dr. Masatoshi TAKEICHI,
Professor Emeritus, Kyoto University7 core programs and 19 creative research promotion programsNumber of Researchers: approx. 330
Research MissionTechniques for use of stem cells including human ES cellsBirth mechanisms of cloned miceVertebrate axis formation in zebrafish and miceDevelopmental mechanics of nematodes and drosophila
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Other Core Facilities Other Core Facilities ⅠⅠ
Business Support Center forBusiness Support Center forBiomedical Research Activities Biomedical Research Activities (BMA)(BMA)
Provides special research environment (cell processing center, animal laboratory, RI facility) for biomedical VBs and companies related to regenerative medicine
Translational Research Translational Research Informatics CenterInformatics Center (TRI)(TRI)
Providing information and supporting fortranslational research Management of clinical trial and supporting data management Establishment of management system of disease data and outcome research dataProviding cancer-related information via internet
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Other Core FacilitiesOther Core Facilities ⅡⅡ
Kobe Biotechnology Research Kobe Biotechnology Research and Human Resource and Human Resource Development Center (BT Center) / Development Center (BT Center) / Kobe University Business Kobe University Business Incubation CenterIncubation CenterPursues research and human resource development in advanced science and technology
Kobe Medical Device Kobe Medical Device Development Center (MEDDEC)Development Center (MEDDEC)
R&D and training of catheter and endoscopeOperating room MRI laboratoryDevice development corner for small-medium companiesRental laboratoryBreeding and observation space
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Other Core FacilitiesOther Core Facilities ⅢⅢ
Center forCenter forMolecular Imaging ScienceMolecular Imaging Science
RIKEN, venture companySpeeding up the process of identifying candidate materials for the design of new drugs and medications
Kobe Healthcare Industry Kobe Healthcare Industry Development CenterDevelopment Center
Development of Bio-experiment devicesDiagnostic and preventive devicesHealthcare devices
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Incentives for Business ActivitiesIncentives for Business ActivitiesKobe Biomedical Venture Fund
Total 8.3 billion yen, invested in total 84 companiesGP: Daiwa SMBC Capital Co., Ltd. Venture capital fund specialized in biomedical business
Incentives by the Kobe Enterprise Zone Ordinance
Kobe Life Science IP Fund0.5 billion yen, invested in 5 companiesGP: Nomura Research & Advisories Co., Ltd.Supports establishment of venture businesses utilizing their intellectual properties
Establishment of the “Pro-Cluster Kobe”Provides comprehensive and professional support for commercialization and
human resource development
Tax reductions and subsidies for land purchase/leaseEstablishment of the Pilot Enterprise Zone in Port Island 2nd Stage(Land rent waiver for 10 years)
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３Sport and Recreation Field
１１Kobe Medical Device Development Center
６Business Facilities Area
１１Port Island 1st Stage
１Center for Molecular Imaging Science
７Kobe Healthcare Industry Development Center
９Kobe Incubation Office
Number of companiesLocation
２Kobe University Business Incubation Center
２５KIMEC Center Building
１０Institute of Biomedical Research and Innovation
２Translational Research Informatics Center
９Business Support Center for Biomedical Research Activities
１４Manufacturing Plant Area
５Pilot Enterprise Zone
２３Kobe International Business Center
１３８TOTAL
Business Expansion into Port Island
Foreign-affiliated companies：18 (7 countries)
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Renewed Kobe City General HospitalRenewed Kobe City General Hospital
Planned capacity: 700 beds (max. 1,000 beds in time of emergency)
Budget: ¥48 billionScheduled to open in FY2010
A hospital that patients and their families can visit and stay with comfort
A hospital that can function properly in times of emergency
A hospital that can operate in environmentally-sound manner
A hospital that can adapt to changes in medical environment
PoliciesPolicies
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Constant health management through at-home medical checkup
Counseling
Medical institutions
Sport facilities
Health Insurance Administrator Private Companies
“Athletes’ town”project
Kobe AirportTourists from inside Tourists from inside and outside Japanand outside Japan Kansai International Airport
① Maintain citizens’health in local settings
④ Enhance Kobe’s attractiveness through health promotion
② Support commercialization by private companies
③ Attract healthcare-related companies
Creating a HealthCreating a Health--Conscious CityConscious CityIn affiliation with Kobe Medical Industry Development ProjectIn affiliation with Kobe Medical Industry Development Project
KOBE MEDICAL INDUSTRY DEVELOPMENT PROJECT
WHO Kobe CenterWHO Kobe Center
Kobe City General HospitalKobe City General Hospital
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As part of the ‘Health Creation Support System,’ the website ‘Lively Kobe Health Club’ (http://www.hatsuratsu-kobe.jp), provides information on diabetes prevention.
Fujiwara-No-Michinaga, considered to be the first person to suffer from diabetes in our country, will guide you!
○’Kobe Health Walk’○Health Information Website
Held every year since FY2005 in each wards to encourage waking for health promotion.
What effects does wearing fit shoes and walking properly have on health?The Program aims to make scientific validation of ‘Promoting Health by Walking’.(Participated by one hundred self-reliant senior citizens in Suma-Tomogaoka Community, 2006）(Participated by three hundred daycare recipients, 2007）
(Project of Ministry of Health, Labor, and Welfare)
○Walking Support ProgramBy making use of ICT and in cooperation with Kobe Women’s University, the program develops a ‘Nutrition Guidance System’, which can collect the citizens’food information and analyze and evaluate nutritional balance and calories taken. The system is planned to be put in use in adult daycare service facilities.(Supported by the Ministry of Health, Labor, and Welfare)
○Nutrition Guidance Program
あなたの1週間の食事を選んで下さい
月曜日の食事
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
合計 4567k㌍
火曜日の食事
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
合計 4567k㌍
水曜日の食事
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
ＸＸＸＸＸＸ 123k㌍
合計 4567k㌍
クリックすると実物大の写真に
Health Exercise
‘Health-Conscious City’ InitiativeSpecific Projects
Shoe Fitting
○’Walking Mileage Experimental Project’In cooperation with the Health Ministry’s research group, the project aims to figure out what incentives are effective in ensuring the continuance of habitual exercising（Started in 2007）
Walking Benefits to communities
DataTransmission
Transmitters are installed in convenience stores, Co-op supermarkets and other places (total 50 places) to send pedometer data
(Afforestation)
Data Reader
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NextNext--Generation SupercomputerGeneration Supercomputer
Developed by the Ministry of Education and RIKEN (Budget ¥110 billion)
Computing capacity: Over 10 petaflops(1016/sec. – 36 times faster than the world’s fastest computer now existing)
Scheduled to start partial operation in FY2010
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General Outline of Kobe Life Science Innovative ProgramGeneral Outline of Kobe Life Science Innovative Program
Outcome of Kobe Medical Industry
Development Project
Environmental change of Kobe Medical Industry
Kobe Life Science Innovative ProgramKobe Life Science Innovative Program１．Grand Designs of the cluster in 10 and 20 years２．New propulsion plan of research and technology development ３．．Scheme for supporting continuance promotion of cluster formationScheme for supporting continuance promotion of cluster formation
Creating next generation
medical system
Consideration for operationProposal of promotion plan
Rolling System ( Proposal and evaluation of a new project
scheme)
Discussion Report in March 1999
Contribution to global community
Raising medical service and welfare level.
Securing employments and revitalizing Kobe economy
Goals
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MedicalTreatment
（Consumption）
MedicalMedicalTreatmentTreatment
（（ConsumptionConsumption））
EmploymentEmploymentEmployment
Disease Prevention
（Investment）
Disease Prevention
（Investment）
Hospitals（Clinicians）HospitalsHospitals
（（CliniciansClinicians））
Basic ResearchBasic Research
Universities（Researchers）UniversitiesUniversities（（ResearchersResearchers））
InvestmentInvestmentR&D / business developmentR&D / business development
System to promote innovation（Medical Innovation System）
System to promote innovation（Medical Innovation System）
Advanced Medical Service（Medical Cluster）
Advanced Medical Service（Medical Cluster）
Scientifically-based health promotion（Creating a “Health-Conscious City”）
Scientifically-based health promotion（Creating a “Health-Conscious City”）
Strengthen basic research functionStrengthen basic research function
Translational ResearchTranslational Research
Benefits to
Citizens
Benefits to
Citizens
Establishment of a Next-generation Medical System
Core Functions of the ProjectCore Functions of the Project
Companies
Human ResourcesHuman ResourcesMedical StaffMedical StaffResearchersResearchers
New Functions for the Cluster Formation
Business Development Support （Medical Business Support Center）
Human Resource Development （Training Center）
Infrastructure developedby the City
Kobe Cluster Formation StrategyKobe Cluster Formation StrategyStrengthen translational research (TR) support functionEnsure sustainable cluster developmentCreate a “Medical Innovation System” to promote innovationBring benefits to citizens and create new industries
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Training of medical doctors specialized in advanced treatment such as transplantations or minimal invasive treatment, and radiation imaging
diagnosis devices, or treatment devices.
Proposal of a scheme for securing the number of doctors and training doctors specialized in the regionally needful and new medical field.
Kobe CitizensKobe CitizensKobe Citizens
Local Clinics and hospitalsClinicians
Local Clinics and hospitalsLocal Clinics and hospitalsCliniciansClinicians
Strategy for the Formation of Medical ClusterStrategy for the Formation of Medical Cluster
CoordinatorCoordinator
Cardiac AffectionCardiac Affection
InfectionInfectionInfection
Kyoto University
Kyoto Kyoto UniversityUniversity
OsakaUniversity
OsakaOsakaUniversityUniversity Kobe
UniversityKobeKobe
UniversityUniversity
Hyogo College of Medicine
Hyogo College Hyogo College of Medicineof Medicine Other UniversitiesOther UniversitiesOther Universities
Medical Institutions (Domestic and Overseas)Medical Institutions (Domestic and Overseas)Medical Institutions (Domestic and Overseas)Domestic PatientsDomestic PatientsDomestic Patients Overseas PatientsOverseas PatientsOverseas Patients
＜＜Regional MedicineRegional Medicine＞＞
＜＜Advanced MedicineAdvanced Medicine＞＞ IBRIIBRI
Kobe City General Hospital Advanced Medical Center
OrganizerOrganizer
Set Advanced Medical Center in Kobe Set Advanced Medical Center in Kobe City General Hospital as a Satellite.City General Hospital as a Satellite.
Relocation and Sophistication Relocation and Sophistication
of Medical Institutionsof Medical Institutions
Attract University Hospitals Attract University Hospitals
and National Hospitalsand National Hospitals
Cancer Transplantation, Regenerative
Medicine
Highly Advanced HospitalsChild Health and
Development
Cerebral Stroke
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Creating a Health-Conscious City
Foundation for BiomedicalResearch and Innovation
Foundation for BiomedicalResearch and Innovation
Family doctors, etc.Family doctors, etc.
“Healthy”Advice
Primary screening
Urinarysugar
BloodPressure BMI
Health Promotion Support SystemHealth Promotion Support System
“Nice-Aging” AdvicePrecautiousdiagnosis
（cancer/dementia/joint disorder）
MRCTPET
(eating/walking/sleeping)
Walking exercisesﾞ
60 yrs. old
Health CardHealth Card
TRIOutcome
Evaluation
Reducing care-
needed people
Creating a city w
ithhealthy and m
acrobiancitizens
5 yrs. / 10 years
Annual medical check-up
Diagnosis every five years
Toward younger people Health point
Check-up data
Supporting ScientificallySupporting Scientifically--Based Based Health PromotionHealth Promotion
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Economic Effects Estimation Economic Effects Estimation (by Nomura Research Institute, Ltd.)
5,062(2,066)
2,690(744)
1,282(176)
Effect on Tax Revenue (million yen)
162,477(73,097)
82,236(24,195)
40,939(5,595)
Generated Wealth(million yen)
9,745(4,237)
5,599(1,999)
2,690(593)
GeneratedEmployment
311(311)
203(203)
172(75)
Number of Companies
201520102005Fiscal Year
*Figures in parenthesis are those of medical-related companies in Port Island 2nd Stage
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IBRI： Institute of Biomedical Research and InnovationCDB： RIKEN Center For Developmental BiologyCMIS : RIKEN Center for Molecular Imaging ScienceKIMEC： Kobe KIMEC Center Bldg.TRI： Translational Research Informatics CenterBMA： Business Support Center for Biomedical Research ActivitiesBT： Kobe Univ. Business Incubation Center/
Kobe Biotechnology Research and Human ResourceDevelopment Center
KIBC： Kobe International Business CenterHI-DEC： Kobe Healthcare Industry Research CenterKIO： Kobe Incubation OfficeMEDDEC： Kobe Medical Device Development Center
Kobe Airport
Medical ZoneMedical Zone⇒ For Advanced Medical
Treatment on Patients’demand
R&D ZoneR&D Zone⇒ Facilities and Support for
R&DCDB
KIBC
IBRI
PEZ
MEDDEC
KIO
BT Center
BMA,TRIKIMEC
Kobe City General Hospital
Hyogo College of MedicineShukugawa Gakuin College
Kobe Gakuin University
Planned Site for Relocation of Kobe City
General Hospital
CMIS
Kobe Women’s University
Convention Complex
Academic ZoneAcademic Zone⇒ For Academic Collaboration
Guideline for the Ground DesignGuideline for the Ground Design（（Port Island AreaPort Island Area））
HI-DEC
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Kobe AirportKobe Airport
SPRING-8SPRING-8
Kobe UniversityKobe University
Kyoto UniversityKyoto University
National Cardiovascular Center
National Cardiovascular Center
National Institute of National Institute of
AISTAIST
Kobe Medical Industry Development Project
Kobe Medical Industry Development Project
“Saito”“Saito”
Osaka Dosho-machiOsaka Dosho-machi
RIKEN CDBRIKEN CDB
RIKENMolecular Imaging
RIKENMolecular Imaging
IBRIIBRI
Osaka AirportOsaka Airport
Bio Triangle of Bio Triangle of KnowledgeKnowledge
Kansai Science CityKansai Science City
Kyoto Bio City ConceptionKyoto Bio City Conception
Super Cluster Formation in Kansai AreaSuper Cluster Formation in Kansai Area
Osaka UniversityOsaka University
Biomedical Clusters around
the world
Universities /Research Institutes
Universities /Research Institutes
Enterprises/Business Support System
Enterprises/Business Support System
Domestic Biomedical
Cluster
Universities/Research Institutes
Universities/Research Institutes
Enterprises/
Business Support System
Enterprises/
Business Support System
Kansai International Airport
Pharmaceutical Companies
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Support to
Obtain Pate
ntsLicensing
Bio Cluster In Asia
Kansai Network of Universities and Institutions
Medical Devices, Pharmaceutical Industries, Generic Drugs, Bio Ventures
New Facilities for New Facilities for Medical TrialsMedical Trials
Bio Venture Promotion Fund
Trading Companies
Bio Cluster In Europe and
the U.S.
Marketin
g SupportIntroduction of
Quality CompaniesDevelopment support
Clinical Research
International Bio Venture International Bio Venture DevelopmentDevelopment
Collaboration with universities and companies
Medical Medical DevicesDevices
Pharmaceutical Pharmaceutical IndustriesIndustries
Research Research InstitutionsInstitutions
Drug Discovery、Protein-DNA Analysis, Diagnostic Devices, Therapeutic Devices, DDS
TRI
MEDDEC
Pharmaceutical Industries
Medical-device Manufacturers
Attract managers
International International Bridging StudyBridging Study
Utilization of Utilization of Imaging Imaging
TechniquesTechniques
HRHR ContributionContribution
Molecular Imaging
IBRI
Venture Capital
Local Medium-Small Enterprises
TechnologiesTechnologies
Developing an International Life Science ClusterDeveloping an International Life Science Cluster（（Kobe Life Science GatewayKobe Life Science Gateway））