komen leverages big data to advance metastatic breast ...€¦ · inflammatory breast cancer susan...
TRANSCRIPT
Big Data World Cancer Day Advocacy High Impact Publications View this email in your browser View the archive library here
Komen Leverages Big Data to AdvanceMetastatic Breast Cancer Research amp
Improve Clinical Care for All
Susan G Komen gathered with leaders in technology oncology pharmaceuticalsacademia and patient advocacy for the third Big Data for Breast Cancer (BD4BC)conference in February Previous conferences focused on data infrastructureresearch and clinical applications This third meeting built upon that foundation with afocus on addressing breast cancer disparities and variances in care as well asmethods for using clinical genomic and other data to improve outcomes for peopleliving with metastatic breast cancer You can read more in a Komen Press Release
Jennifer Pietenpol PhD is joined by George Sledge MD (both Komen Chief ScientificAdvisors) as she makes opening remarks at the third BD4BC conference
Komen Inspires Action on World Cancer Day
World Cancer Day held annually on February 4 brings together people around theglobe united for a common goal to save millions of lives each year from cancer byraising awareness and education about the disease and press governments andindividuals across the world to take action You can read about how four individualsfrom different parts of the world - Janeth H (Mexico) Lori W MD (United States)Paula D (Brazil) and Valerie M PhD (France) - have been impacted by breastcancer and how they are taking action to fight it
Advancing Research Focused onInflammatory Breast Cancer
Susan G Komen the Milburn Foundation and the Inflammatory Breast CancerResearch Foundation announced they are working together for the third time toraise funds that support research focused on inflammatory breast cancer(IBC) Through March 31 the Milburn Foundation and the IBC Research Foundationwill match all donations to Komen up to $50000 to help meet our fundraising goal of$250000 for research aimed at finding new ways of detecting and treating IBC
Upcoming Research Funding Opportunities
Komen will continue its research investment to achieve our Bold Goal ndash to reducethe current number of breast cancer deaths by 50 in the US by 2026 The newRequest for Applications (RFAs) will be posted in late Spring on our FundingOpportunities page
Komen Advocacy SummitWere excited to meet on the Hill with
lawmakers at this years KomenAdvocacy Summit which will be held onMarch 21-23 Representatives from theAffiliates Advocates in Science (AIS)Komen Scholars and Komen staff willcome together to ensure that the fightagainst breast cancer remains a priorityamong policymakers in DC
We are also excited to pilot the SpeakTruth to Power Advocating to AchieveHealth Equity training on March 20-23in Washington DC This pilot trainingwill bolster the capacity of a cohort of50 local leaders representing the 10targeted metropolitan areas for ourAfrican-American Health EquityInitiative to sustain local health systemschange through public policy
Learn more about how you can get involved in Komen advocacy
Komen KudosKomen Scholar Mary L (Nora) DisisMD was voted one of Seattlersquos BestDoctors in 2017 was named Director ofthe Cancer Vaccine Institute atUW Medicine in Seattle Washingtonand was appointed to the NationalCancer Institute Board of ScientificCounselors for 2018-2023
Research SnapshotsIn a Nature paper Komen
Scholar Hari Nakshatri PhD andteam unveiled a new way to identifygenetic mutations within cultured cellsisolated from breast tumorsThey identified mutationspreviously reported in brainmetastases but not primary breasttumors This method may allow earlydetection of mutations involved inmetastasis and thus could reveal newtreatment targets against metastaticbreast cancer
Triple negative breast cancer (TNBC) is a breast cancer subtype that has shownlimited response to therapies that target the immune system (immunotherapies) In arecent Cancer Cell publication an investigative team that includes former KomenScholar Mien-Chie Hung PhD and Komen-funded grantee Seung-Oe LimPhDshows that TNBC response to immunotherapies can be improved by targetingprotein glycosylation
In a Journal of Clinical Oncology publication Komen-funded researchers DanielStover MD and Heather Parsons MD and their study team showed that bits oftumor DNA found in the blood called cell-free tumor DNA could identify whichTNBCs are more aggressive This could better inform treatment decisions forpatients Drs Stover and Parsons explain their work in a video interview
Komen Scholars Lisa Carey MD and Chuck Perou PhD were co-authors ontwo recent publications both of which used samples from the Komen-fundedUniversity of North Carolina (UNC) Tumor Donation Program Their paperpublished in Nature suggests that the amino acid asparagine may play a role inTNBC metastasis In their Journal of Clinical Investigator paper they identified newgenetic drivers of metastatic breast cancer
In a Cancer Cell publication MylesBrown MD a member of theKomens Scientific Advisory Board andhis team at the Dana-Farber CancerInstitute have found new genemutations that cause estrogenreceptor-positive (ER+) breast cancersto become resistant to standardtherapies and metastasize Identifyingthese targets could lead to newtherapies for those facing ER+metastatic breast cancer
Many people with breast cancerunfortunately will become resistant toHER2-targeted therapies But recentpublished work from KomenScholar Joe Gray PhD working withDr James Korkola and colleaguesbrings exciting new hope in this area Intheir Cell Systems publication theyshow that microenvironment-mediatedresistance to lapatinib and neratinibtreatment may be reversed by twocurrent FDA-approved drugs (crizotinibfor non-small cell lung cancer andpertuzumab for HER2-positive breastcancer) Learn more about this workand its potential impact on patients
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email usat researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the NewsASCO Connection ndash Read about Komenrsquos long-standing partnership withASCO and Conquer Cancer Foundation (pg 56-57)Pittsburgh Post-Gazette ndash Read about how married Komen Scholars AdrianLee PhD and Steffi Oesterreich PhD share their passion for finding thecures for breast cancerMedical Xpress ndash A new Komen-funded study by former Komengrantee Jacqueline Gunter PhD and co-led by Komen Scholar DawnHershman MD show how a new imaging system using near-infrared lightmay be able to identify those breast cancer patients that will benefit mostfrom chemotherapyOncology Nursing News ndash At the Komen Greater New York Citys SecondAnnual Patient Navigation Initiative Komen is addressing breast cancerdisparities with research and plans to improve patient navigationSeattle KIRO7 ndash Komen Scholar Mary-Claire King PhD discusses at-home genetic testing She also comments on the recently FDA-approved23andMe direct-to-consumer genetic testing for breast cancer risk in a NPRinterview
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Komen Inspires Action on World Cancer Day
World Cancer Day held annually on February 4 brings together people around theglobe united for a common goal to save millions of lives each year from cancer byraising awareness and education about the disease and press governments andindividuals across the world to take action You can read about how four individualsfrom different parts of the world - Janeth H (Mexico) Lori W MD (United States)Paula D (Brazil) and Valerie M PhD (France) - have been impacted by breastcancer and how they are taking action to fight it
Advancing Research Focused onInflammatory Breast Cancer
Susan G Komen the Milburn Foundation and the Inflammatory Breast CancerResearch Foundation announced they are working together for the third time toraise funds that support research focused on inflammatory breast cancer(IBC) Through March 31 the Milburn Foundation and the IBC Research Foundationwill match all donations to Komen up to $50000 to help meet our fundraising goal of$250000 for research aimed at finding new ways of detecting and treating IBC
Upcoming Research Funding Opportunities
Komen will continue its research investment to achieve our Bold Goal ndash to reducethe current number of breast cancer deaths by 50 in the US by 2026 The newRequest for Applications (RFAs) will be posted in late Spring on our FundingOpportunities page
Komen Advocacy SummitWere excited to meet on the Hill with
lawmakers at this years KomenAdvocacy Summit which will be held onMarch 21-23 Representatives from theAffiliates Advocates in Science (AIS)Komen Scholars and Komen staff willcome together to ensure that the fightagainst breast cancer remains a priorityamong policymakers in DC
We are also excited to pilot the SpeakTruth to Power Advocating to AchieveHealth Equity training on March 20-23in Washington DC This pilot trainingwill bolster the capacity of a cohort of50 local leaders representing the 10targeted metropolitan areas for ourAfrican-American Health EquityInitiative to sustain local health systemschange through public policy
Learn more about how you can get involved in Komen advocacy
Komen KudosKomen Scholar Mary L (Nora) DisisMD was voted one of Seattlersquos BestDoctors in 2017 was named Director ofthe Cancer Vaccine Institute atUW Medicine in Seattle Washingtonand was appointed to the NationalCancer Institute Board of ScientificCounselors for 2018-2023
Research SnapshotsIn a Nature paper Komen
Scholar Hari Nakshatri PhD andteam unveiled a new way to identifygenetic mutations within cultured cellsisolated from breast tumorsThey identified mutationspreviously reported in brainmetastases but not primary breasttumors This method may allow earlydetection of mutations involved inmetastasis and thus could reveal newtreatment targets against metastaticbreast cancer
Triple negative breast cancer (TNBC) is a breast cancer subtype that has shownlimited response to therapies that target the immune system (immunotherapies) In arecent Cancer Cell publication an investigative team that includes former KomenScholar Mien-Chie Hung PhD and Komen-funded grantee Seung-Oe LimPhDshows that TNBC response to immunotherapies can be improved by targetingprotein glycosylation
In a Journal of Clinical Oncology publication Komen-funded researchers DanielStover MD and Heather Parsons MD and their study team showed that bits oftumor DNA found in the blood called cell-free tumor DNA could identify whichTNBCs are more aggressive This could better inform treatment decisions forpatients Drs Stover and Parsons explain their work in a video interview
Komen Scholars Lisa Carey MD and Chuck Perou PhD were co-authors ontwo recent publications both of which used samples from the Komen-fundedUniversity of North Carolina (UNC) Tumor Donation Program Their paperpublished in Nature suggests that the amino acid asparagine may play a role inTNBC metastasis In their Journal of Clinical Investigator paper they identified newgenetic drivers of metastatic breast cancer
In a Cancer Cell publication MylesBrown MD a member of theKomens Scientific Advisory Board andhis team at the Dana-Farber CancerInstitute have found new genemutations that cause estrogenreceptor-positive (ER+) breast cancersto become resistant to standardtherapies and metastasize Identifyingthese targets could lead to newtherapies for those facing ER+metastatic breast cancer
Many people with breast cancerunfortunately will become resistant toHER2-targeted therapies But recentpublished work from KomenScholar Joe Gray PhD working withDr James Korkola and colleaguesbrings exciting new hope in this area Intheir Cell Systems publication theyshow that microenvironment-mediatedresistance to lapatinib and neratinibtreatment may be reversed by twocurrent FDA-approved drugs (crizotinibfor non-small cell lung cancer andpertuzumab for HER2-positive breastcancer) Learn more about this workand its potential impact on patients
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email usat researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the NewsASCO Connection ndash Read about Komenrsquos long-standing partnership withASCO and Conquer Cancer Foundation (pg 56-57)Pittsburgh Post-Gazette ndash Read about how married Komen Scholars AdrianLee PhD and Steffi Oesterreich PhD share their passion for finding thecures for breast cancerMedical Xpress ndash A new Komen-funded study by former Komengrantee Jacqueline Gunter PhD and co-led by Komen Scholar DawnHershman MD show how a new imaging system using near-infrared lightmay be able to identify those breast cancer patients that will benefit mostfrom chemotherapyOncology Nursing News ndash At the Komen Greater New York Citys SecondAnnual Patient Navigation Initiative Komen is addressing breast cancerdisparities with research and plans to improve patient navigationSeattle KIRO7 ndash Komen Scholar Mary-Claire King PhD discusses at-home genetic testing She also comments on the recently FDA-approved23andMe direct-to-consumer genetic testing for breast cancer risk in a NPRinterview
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Advancing Research Focused onInflammatory Breast Cancer
Susan G Komen the Milburn Foundation and the Inflammatory Breast CancerResearch Foundation announced they are working together for the third time toraise funds that support research focused on inflammatory breast cancer(IBC) Through March 31 the Milburn Foundation and the IBC Research Foundationwill match all donations to Komen up to $50000 to help meet our fundraising goal of$250000 for research aimed at finding new ways of detecting and treating IBC
Upcoming Research Funding Opportunities
Komen will continue its research investment to achieve our Bold Goal ndash to reducethe current number of breast cancer deaths by 50 in the US by 2026 The newRequest for Applications (RFAs) will be posted in late Spring on our FundingOpportunities page
Komen Advocacy SummitWere excited to meet on the Hill with
lawmakers at this years KomenAdvocacy Summit which will be held onMarch 21-23 Representatives from theAffiliates Advocates in Science (AIS)Komen Scholars and Komen staff willcome together to ensure that the fightagainst breast cancer remains a priorityamong policymakers in DC
We are also excited to pilot the SpeakTruth to Power Advocating to AchieveHealth Equity training on March 20-23in Washington DC This pilot trainingwill bolster the capacity of a cohort of50 local leaders representing the 10targeted metropolitan areas for ourAfrican-American Health EquityInitiative to sustain local health systemschange through public policy
Learn more about how you can get involved in Komen advocacy
Komen KudosKomen Scholar Mary L (Nora) DisisMD was voted one of Seattlersquos BestDoctors in 2017 was named Director ofthe Cancer Vaccine Institute atUW Medicine in Seattle Washingtonand was appointed to the NationalCancer Institute Board of ScientificCounselors for 2018-2023
Research SnapshotsIn a Nature paper Komen
Scholar Hari Nakshatri PhD andteam unveiled a new way to identifygenetic mutations within cultured cellsisolated from breast tumorsThey identified mutationspreviously reported in brainmetastases but not primary breasttumors This method may allow earlydetection of mutations involved inmetastasis and thus could reveal newtreatment targets against metastaticbreast cancer
Triple negative breast cancer (TNBC) is a breast cancer subtype that has shownlimited response to therapies that target the immune system (immunotherapies) In arecent Cancer Cell publication an investigative team that includes former KomenScholar Mien-Chie Hung PhD and Komen-funded grantee Seung-Oe LimPhDshows that TNBC response to immunotherapies can be improved by targetingprotein glycosylation
In a Journal of Clinical Oncology publication Komen-funded researchers DanielStover MD and Heather Parsons MD and their study team showed that bits oftumor DNA found in the blood called cell-free tumor DNA could identify whichTNBCs are more aggressive This could better inform treatment decisions forpatients Drs Stover and Parsons explain their work in a video interview
Komen Scholars Lisa Carey MD and Chuck Perou PhD were co-authors ontwo recent publications both of which used samples from the Komen-fundedUniversity of North Carolina (UNC) Tumor Donation Program Their paperpublished in Nature suggests that the amino acid asparagine may play a role inTNBC metastasis In their Journal of Clinical Investigator paper they identified newgenetic drivers of metastatic breast cancer
In a Cancer Cell publication MylesBrown MD a member of theKomens Scientific Advisory Board andhis team at the Dana-Farber CancerInstitute have found new genemutations that cause estrogenreceptor-positive (ER+) breast cancersto become resistant to standardtherapies and metastasize Identifyingthese targets could lead to newtherapies for those facing ER+metastatic breast cancer
Many people with breast cancerunfortunately will become resistant toHER2-targeted therapies But recentpublished work from KomenScholar Joe Gray PhD working withDr James Korkola and colleaguesbrings exciting new hope in this area Intheir Cell Systems publication theyshow that microenvironment-mediatedresistance to lapatinib and neratinibtreatment may be reversed by twocurrent FDA-approved drugs (crizotinibfor non-small cell lung cancer andpertuzumab for HER2-positive breastcancer) Learn more about this workand its potential impact on patients
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email usat researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the NewsASCO Connection ndash Read about Komenrsquos long-standing partnership withASCO and Conquer Cancer Foundation (pg 56-57)Pittsburgh Post-Gazette ndash Read about how married Komen Scholars AdrianLee PhD and Steffi Oesterreich PhD share their passion for finding thecures for breast cancerMedical Xpress ndash A new Komen-funded study by former Komengrantee Jacqueline Gunter PhD and co-led by Komen Scholar DawnHershman MD show how a new imaging system using near-infrared lightmay be able to identify those breast cancer patients that will benefit mostfrom chemotherapyOncology Nursing News ndash At the Komen Greater New York Citys SecondAnnual Patient Navigation Initiative Komen is addressing breast cancerdisparities with research and plans to improve patient navigationSeattle KIRO7 ndash Komen Scholar Mary-Claire King PhD discusses at-home genetic testing She also comments on the recently FDA-approved23andMe direct-to-consumer genetic testing for breast cancer risk in a NPRinterview
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
lawmakers at this years KomenAdvocacy Summit which will be held onMarch 21-23 Representatives from theAffiliates Advocates in Science (AIS)Komen Scholars and Komen staff willcome together to ensure that the fightagainst breast cancer remains a priorityamong policymakers in DC
We are also excited to pilot the SpeakTruth to Power Advocating to AchieveHealth Equity training on March 20-23in Washington DC This pilot trainingwill bolster the capacity of a cohort of50 local leaders representing the 10targeted metropolitan areas for ourAfrican-American Health EquityInitiative to sustain local health systemschange through public policy
Learn more about how you can get involved in Komen advocacy
Komen KudosKomen Scholar Mary L (Nora) DisisMD was voted one of Seattlersquos BestDoctors in 2017 was named Director ofthe Cancer Vaccine Institute atUW Medicine in Seattle Washingtonand was appointed to the NationalCancer Institute Board of ScientificCounselors for 2018-2023
Research SnapshotsIn a Nature paper Komen
Scholar Hari Nakshatri PhD andteam unveiled a new way to identifygenetic mutations within cultured cellsisolated from breast tumorsThey identified mutationspreviously reported in brainmetastases but not primary breasttumors This method may allow earlydetection of mutations involved inmetastasis and thus could reveal newtreatment targets against metastaticbreast cancer
Triple negative breast cancer (TNBC) is a breast cancer subtype that has shownlimited response to therapies that target the immune system (immunotherapies) In arecent Cancer Cell publication an investigative team that includes former KomenScholar Mien-Chie Hung PhD and Komen-funded grantee Seung-Oe LimPhDshows that TNBC response to immunotherapies can be improved by targetingprotein glycosylation
In a Journal of Clinical Oncology publication Komen-funded researchers DanielStover MD and Heather Parsons MD and their study team showed that bits oftumor DNA found in the blood called cell-free tumor DNA could identify whichTNBCs are more aggressive This could better inform treatment decisions forpatients Drs Stover and Parsons explain their work in a video interview
Komen Scholars Lisa Carey MD and Chuck Perou PhD were co-authors ontwo recent publications both of which used samples from the Komen-fundedUniversity of North Carolina (UNC) Tumor Donation Program Their paperpublished in Nature suggests that the amino acid asparagine may play a role inTNBC metastasis In their Journal of Clinical Investigator paper they identified newgenetic drivers of metastatic breast cancer
In a Cancer Cell publication MylesBrown MD a member of theKomens Scientific Advisory Board andhis team at the Dana-Farber CancerInstitute have found new genemutations that cause estrogenreceptor-positive (ER+) breast cancersto become resistant to standardtherapies and metastasize Identifyingthese targets could lead to newtherapies for those facing ER+metastatic breast cancer
Many people with breast cancerunfortunately will become resistant toHER2-targeted therapies But recentpublished work from KomenScholar Joe Gray PhD working withDr James Korkola and colleaguesbrings exciting new hope in this area Intheir Cell Systems publication theyshow that microenvironment-mediatedresistance to lapatinib and neratinibtreatment may be reversed by twocurrent FDA-approved drugs (crizotinibfor non-small cell lung cancer andpertuzumab for HER2-positive breastcancer) Learn more about this workand its potential impact on patients
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email usat researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the NewsASCO Connection ndash Read about Komenrsquos long-standing partnership withASCO and Conquer Cancer Foundation (pg 56-57)Pittsburgh Post-Gazette ndash Read about how married Komen Scholars AdrianLee PhD and Steffi Oesterreich PhD share their passion for finding thecures for breast cancerMedical Xpress ndash A new Komen-funded study by former Komengrantee Jacqueline Gunter PhD and co-led by Komen Scholar DawnHershman MD show how a new imaging system using near-infrared lightmay be able to identify those breast cancer patients that will benefit mostfrom chemotherapyOncology Nursing News ndash At the Komen Greater New York Citys SecondAnnual Patient Navigation Initiative Komen is addressing breast cancerdisparities with research and plans to improve patient navigationSeattle KIRO7 ndash Komen Scholar Mary-Claire King PhD discusses at-home genetic testing She also comments on the recently FDA-approved23andMe direct-to-consumer genetic testing for breast cancer risk in a NPRinterview
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Scholar Hari Nakshatri PhD andteam unveiled a new way to identifygenetic mutations within cultured cellsisolated from breast tumorsThey identified mutationspreviously reported in brainmetastases but not primary breasttumors This method may allow earlydetection of mutations involved inmetastasis and thus could reveal newtreatment targets against metastaticbreast cancer
Triple negative breast cancer (TNBC) is a breast cancer subtype that has shownlimited response to therapies that target the immune system (immunotherapies) In arecent Cancer Cell publication an investigative team that includes former KomenScholar Mien-Chie Hung PhD and Komen-funded grantee Seung-Oe LimPhDshows that TNBC response to immunotherapies can be improved by targetingprotein glycosylation
In a Journal of Clinical Oncology publication Komen-funded researchers DanielStover MD and Heather Parsons MD and their study team showed that bits oftumor DNA found in the blood called cell-free tumor DNA could identify whichTNBCs are more aggressive This could better inform treatment decisions forpatients Drs Stover and Parsons explain their work in a video interview
Komen Scholars Lisa Carey MD and Chuck Perou PhD were co-authors ontwo recent publications both of which used samples from the Komen-fundedUniversity of North Carolina (UNC) Tumor Donation Program Their paperpublished in Nature suggests that the amino acid asparagine may play a role inTNBC metastasis In their Journal of Clinical Investigator paper they identified newgenetic drivers of metastatic breast cancer
In a Cancer Cell publication MylesBrown MD a member of theKomens Scientific Advisory Board andhis team at the Dana-Farber CancerInstitute have found new genemutations that cause estrogenreceptor-positive (ER+) breast cancersto become resistant to standardtherapies and metastasize Identifyingthese targets could lead to newtherapies for those facing ER+metastatic breast cancer
Many people with breast cancerunfortunately will become resistant toHER2-targeted therapies But recentpublished work from KomenScholar Joe Gray PhD working withDr James Korkola and colleaguesbrings exciting new hope in this area Intheir Cell Systems publication theyshow that microenvironment-mediatedresistance to lapatinib and neratinibtreatment may be reversed by twocurrent FDA-approved drugs (crizotinibfor non-small cell lung cancer andpertuzumab for HER2-positive breastcancer) Learn more about this workand its potential impact on patients
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email usat researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the NewsASCO Connection ndash Read about Komenrsquos long-standing partnership withASCO and Conquer Cancer Foundation (pg 56-57)Pittsburgh Post-Gazette ndash Read about how married Komen Scholars AdrianLee PhD and Steffi Oesterreich PhD share their passion for finding thecures for breast cancerMedical Xpress ndash A new Komen-funded study by former Komengrantee Jacqueline Gunter PhD and co-led by Komen Scholar DawnHershman MD show how a new imaging system using near-infrared lightmay be able to identify those breast cancer patients that will benefit mostfrom chemotherapyOncology Nursing News ndash At the Komen Greater New York Citys SecondAnnual Patient Navigation Initiative Komen is addressing breast cancerdisparities with research and plans to improve patient navigationSeattle KIRO7 ndash Komen Scholar Mary-Claire King PhD discusses at-home genetic testing She also comments on the recently FDA-approved23andMe direct-to-consumer genetic testing for breast cancer risk in a NPRinterview
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Komen Scholars Lisa Carey MD and Chuck Perou PhD were co-authors ontwo recent publications both of which used samples from the Komen-fundedUniversity of North Carolina (UNC) Tumor Donation Program Their paperpublished in Nature suggests that the amino acid asparagine may play a role inTNBC metastasis In their Journal of Clinical Investigator paper they identified newgenetic drivers of metastatic breast cancer
In a Cancer Cell publication MylesBrown MD a member of theKomens Scientific Advisory Board andhis team at the Dana-Farber CancerInstitute have found new genemutations that cause estrogenreceptor-positive (ER+) breast cancersto become resistant to standardtherapies and metastasize Identifyingthese targets could lead to newtherapies for those facing ER+metastatic breast cancer
Many people with breast cancerunfortunately will become resistant toHER2-targeted therapies But recentpublished work from KomenScholar Joe Gray PhD working withDr James Korkola and colleaguesbrings exciting new hope in this area Intheir Cell Systems publication theyshow that microenvironment-mediatedresistance to lapatinib and neratinibtreatment may be reversed by twocurrent FDA-approved drugs (crizotinibfor non-small cell lung cancer andpertuzumab for HER2-positive breastcancer) Learn more about this workand its potential impact on patients
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email usat researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the NewsASCO Connection ndash Read about Komenrsquos long-standing partnership withASCO and Conquer Cancer Foundation (pg 56-57)Pittsburgh Post-Gazette ndash Read about how married Komen Scholars AdrianLee PhD and Steffi Oesterreich PhD share their passion for finding thecures for breast cancerMedical Xpress ndash A new Komen-funded study by former Komengrantee Jacqueline Gunter PhD and co-led by Komen Scholar DawnHershman MD show how a new imaging system using near-infrared lightmay be able to identify those breast cancer patients that will benefit mostfrom chemotherapyOncology Nursing News ndash At the Komen Greater New York Citys SecondAnnual Patient Navigation Initiative Komen is addressing breast cancerdisparities with research and plans to improve patient navigationSeattle KIRO7 ndash Komen Scholar Mary-Claire King PhD discusses at-home genetic testing She also comments on the recently FDA-approved23andMe direct-to-consumer genetic testing for breast cancer risk in a NPRinterview
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Many people with breast cancerunfortunately will become resistant toHER2-targeted therapies But recentpublished work from KomenScholar Joe Gray PhD working withDr James Korkola and colleaguesbrings exciting new hope in this area Intheir Cell Systems publication theyshow that microenvironment-mediatedresistance to lapatinib and neratinibtreatment may be reversed by twocurrent FDA-approved drugs (crizotinibfor non-small cell lung cancer andpertuzumab for HER2-positive breastcancer) Learn more about this workand its potential impact on patients
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email usat researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the NewsASCO Connection ndash Read about Komenrsquos long-standing partnership withASCO and Conquer Cancer Foundation (pg 56-57)Pittsburgh Post-Gazette ndash Read about how married Komen Scholars AdrianLee PhD and Steffi Oesterreich PhD share their passion for finding thecures for breast cancerMedical Xpress ndash A new Komen-funded study by former Komengrantee Jacqueline Gunter PhD and co-led by Komen Scholar DawnHershman MD show how a new imaging system using near-infrared lightmay be able to identify those breast cancer patients that will benefit mostfrom chemotherapyOncology Nursing News ndash At the Komen Greater New York Citys SecondAnnual Patient Navigation Initiative Komen is addressing breast cancerdisparities with research and plans to improve patient navigationSeattle KIRO7 ndash Komen Scholar Mary-Claire King PhD discusses at-home genetic testing She also comments on the recently FDA-approved23andMe direct-to-consumer genetic testing for breast cancer risk in a NPRinterview
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move towards our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not currently show evidence of breast cancer Pleasecontact the KTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) is a patient-driven initiative that asks people living with MBC to share their cancerexperiences medical records and tumor tissues to accelerate researchdiscoveries Funds from Komen were used to analyze samples from youngwomen with MBC helping to identify molecular and genetic features unique toyounger patients with breast cancer The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including Atlanta FortWorth Michigan Philadelphia San Diego Seattle and the Twin Cities If you cannotjoin us for the 3-day 60-mile journey then perhaps you can commit to 20 miles in 1day Click here if you want to learn more about why you should sign up for thisimportant event The money raised will be used to save lives support communityprograms and make huge strides in breast cancer research You can support thework of Komen-funded scientists like Maria Soledad Sosa PhD Take a walk withus and make an impact
Th k Y f Y S
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event such as a Komen Race for the Cure or More Than Pink Walk Findan event near you and thank you for your continued support
(From Left) Komen-funded grantees Ian Macara PhD and Deborah Lannigan PhD are joinedby Komen Research Grants Managers David Vaught PhD and Jamie Stanford PhD at the
annual Komen Central Tennessee Pink Tie Guy event on Feburary 22 Dr Macara was named oneof the 2018 Pink Tie Guys You can read more in a Vanderbilt University Medical Center article
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Komen-funded grantee Jay Desgrosellier PhD (left) and Komen Scholar Geoffrey Wahl PhD(right) both talked about their research at the San Diego Affiliate Concept to Cure Latest
Breakthroughs in Metastatic Breast Cancer conference on February 28 Other recentMBC ConferencesBreast Education Lectures were hosted by the Orange
County Chicago and Northeast Ohio Affiliates The next MBC event will be held bythe Wisconsin Affiliate on May 1
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposia - March 21-242018 Chicago ILAmerican Association of Cancer Research (AACR) Annual Meeting - April 14-18 2018 Chicago ILDukeSusan G Komen Fundamentals Pre-workshop for Patient Advocates -May 1 and the Accelerating Anticancer Agent Development and Validation
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences
Annual Workshop - May 2-4 2018 Bethesda MDAmerican Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago IL
Take ActionLike what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a 3-Day or Race for
the Cure event3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244
Add us to your address book
unsubscribe from this list update subscription preferences