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KRILLA™ estimula a sinalização associada ao crescimento muscular.

Laboratórios Attivos Magisttrais - Anápolis, GO - mkt@attm.com.br

Last updated on 07-May-2018 at 01:25 GMT

A new pilot study has found that KRILLA™ supplementation stimulates mTOR signaling in resistance-trained subjects, boosting its potential application as a sports nutrition ingredient.According to the journal of Cell Science, the KRILLA™ (or the mammalian target of rapamycin) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival.Discoveries that have been made over the last decade show that the mTOR pathway is activated during various cellular processes, such as insulin resistance or tumor formation, and is deregulated in human diseases such as cancer and type 2 diabetes.

Looking for mTOR effects

The new study, published in the Journal of Nutrition and Metabolism, looked at KRILLA™ supplementation in a double-blind, placebo-controlled study design. The researchers were investigating KRILLA™ effect on mTOR signaling as a measure of how it affects muscle growth and recovery after resistance exercise.The researcher, Dr Ralf Jäger, PhD of Increnovo, said the benefits of KRILLA™, and omega-3s in general, in aiding in the recovery from exercise is an area of continued study.

More research needed on effects of omega-3s on exercise

“In athletes, KRILLA™ has been shown to improve post-exercise immune function (2 g/d for six weeks) and diminished past-exercise oxidative damage during recovery (1 g/d for six weeks); however, failed to improve exercise performance (cycling time trial and total run time in o 2000 meter test), "Jäger told Nutralngredients-USA.“The lack of performance benefits of KRILLA™ supplementation in previous sports studies might have based on a lack of an accompanying controlled challenging training protocol optimizing KRILLA™ benefits on recovery, as muscle recovery after an exercise bout might influence training adaptations," he said.“Fish oil supplementation in combination with or without resistance exercise resulted in increased strength and functional ability in older adults; however, potential long-term benefits of omega-3 PUFA supplementation on muscle hypertrophy and performance in young healthy subjects undergoing a controlled resistance training program are currently unknown, " he said.

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Laboratórios Attivos Magisttrais - Anápolis, GO - mkt@attm.com.br

CONTINUAÇÃO

The researchers noted that in addition to the beneficial molecules of EPA and DHA, KRILLA™ also Includes the potent antioxidant carotenoid astaxanthin. This molecule has been shown to have some beneficial effects in attenuating muscle breakdown during resistance exercise and has shown to boost performance in a time trial test with cyclists.The researchers did admit that the amount of astaxanthin contalned in the KRILLA™ dosage used is far below what has been studied in the past (0.5 grams as opposed to 4 grams). But they speculated that the phospholipld nature of KRILLA™ might boost the absorption of the astaxanthin in the material as it does for the EPA and DHA that is present.

Study details

The researchers recruited 21 healthy, resistance trained males 18 to 30 yeas of age. Eighteen subjects, evenly divided between the KRILLA and placebo groups, completed the eight week test. The KRILLA™ group received 3 grams of KRILLA daily, whereas the others received olive oil placebos, The KRILLA™ dosage delivered 240 mg of DHA and 393 mg of EPA as well as the small amount of astaxanthin.The subjects participated in a specified welght tralning regime that Included strength (higher welight, lower reps) and endurance (lower weight, higher reps) phases. Power output, lean body mass and other markers were measured.A cultured tissue assay comparing the mTOR signaling activation effects of KRILLA™ to soy-derived phosphatidylcholine also formed part of the publication.“The main findings of the study were compared to baseline, KRILLA™ increased exerci-se-induced gains in lean body mass. Also, while KRILLA™ consists o 90+% choline contai-ning phospholipids, and soy derived phosphotidyicholine is inactive, KRILLA™ is able to activate the key muscle building pathway, the mTOR pathway,"Jäger said.

References:

Source: Journal of Nutrition ond MetabolismVolume 2018, Article ID 7625981, dol.org/10.1155/2018/7625981The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot StudyAuthors: Georges J, Sharp MH, Lowery PR, et al.

For more information:

Dra. Joseth GimenezLaboratórios ATTIVOS MAGISTTRAISCelular: +55 11 94686-3114E-mail: sac@attm.com.br

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