5-YEAR SURVIVAL OF GASTRIC CANCER PATIENTS AFTER COMPLETE GASTRECTOMIES SIGNIFICANTLY DEPENDED ON PHASE TRANSITION “EARLY-INVASIVE CANCER”, LYMPH NODE METASTASES AND CELL RATIO FACTORS

Oleg KshivetsEP144

2012 WCC-1864

5-YEAR SURVIVAL OF GASTRIC CANCER PATIENTS AFTER COMPLETE GASTRECTOMIES SIGNIFICANTLY DEPENDED ON PHASE TRANSITION “EARLY-INVASIVE CANCER”, LYMPH NODE METASTASES AND CELL RATIO FACTORSOleg Kshivets

Poster number EP144

Track 2012WCC-1864

Disclosure of Interest: Declared

Cumulative Proportion Surviving (Kaplan-Meier)Complete Censored

P=0.000 by Log-Rank Test

Years after Gastrectomies

Cum

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Sur

vivi

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0 5 10 15 20 25 30 35 400.0

0.1

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0.9

1.0GCP with N1-2, n=309 GCP with N0, n=303

Cumulative Proportion Surviving (Kaplan-Meier)Complete Censored

P=0.000 by Log-Rank Test

Years after Gastrectomies

Cum

ulat

ive

Pro

port

ion

Sur

vivi

ng

0 5 10 15 20 25 30 35 400.0

0.1

0.2

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0.8

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1.0

Invasive GCP, n=515 Early GCP, n=97

Cox Regression: Variables in the EquationChi2=74.35; df=5;P=0.00000; B SE Wald df Sig. Exp(B)

PT E-I Cancer -,340 ,169 4,047 1 ,044 ,712

PT N0-N12 -,272 ,046 35,091 1 ,000 ,762

Monocytes/CC ,384 ,193 3,947 1 ,047 1,468

Lymphocytes/CC -,098 ,046 4,527 1 ,033 ,906

Erythrocytes/CC ,013 ,021 ,385 1 ,535 1,013

OBJECTIVE: We examined prognostic factors of gastric cancer (GC) patients (GCP) (T1-4N0-2M0) after complete (R0) gastrectomies (GE). 

METHODS: In trial (1975-2011) the data of consecutive 612 GCP after radical surgery (age=56.6±9.4 years; m=422, f=190; tumor diameter=5.7±3.0 cm; distal GE=364, proximal=132, total=116, D2-lymphadenectomy=381, D3-4=231; combined procedures=209; T1=168, T2=182, T3=127, T4=135; N0=303, N1=84, N2=225; G1=175, G2=104, G3=333) was reviewed. Cox regression, clustering, SEPATH, Monte Carlo, bootstrap, neural network simulation were used to determine any significant regularity.

Poster numberEP144

Track2012WCC-1864

Disclosure of Interest: Declared

5-YEAR SURVIVAL OF GASTRIC CANCER PATIENTS AFTER COMPLETE GASTRECTOMIES SIGNIFICANTLY DEPENDED ON PHASE TRANSITION “EARLY-INVASIVE CANCER”, LYMPH NODE METASTASES AND CELL RATIO FACTORSOleg KshivetsRESULTS: Overall life span (LS) was 2015.5±2208.5 days and cumulative 5-year survival (5YS) reached 50.9%, 10 years – 44.2%, 20 years – 32.6%. 222 GCP lived more than 5 years without GC. 271 GCP died because of GC. Cox modeling displayed that 5YS significantly depended on: phase transition (PT) early-invasive GC in terms of synergetics, PT N0-N12, cell ratio factors (CRF) (ratio between cancer cells – CC and blood cells subpopulations) (P=0.000-0.047). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive GC (rank=1), PT N0-N12 (rank=2), healthy cells/CC, erythrocytes/CC, lymphocytes/CC, monocytes/CC, leucocytes/CC, stab neutrophils/CC, eosinophils/CC, segmented neutrophils/CC, thrombocytes/CC. Correct prediction of 5YS was 100% by neural networks computing.

 CONCLUSIONS: 5-year survival of gastric cancer patients after radical gastrectomies significantly depended on: 1)Phase transition “early-invasive cancer”; 2)Phase transition N0-N12; 3)Cell Ratio Factors.