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    APP 96

    LABO RATORY REFERENCE RAN GE VALUES

    Show-Hong Duh, PhD, DABCC, Department of Pathology,University of Maryland School of Medicine

    Janine Denis Cook, PhD, Department of Medical and Research Technology,University of Maryland School of Medicine

    Reference range values are for apparently healthy people and often overlap significantly with values for those who are sick. Actualvalues may vary significantly due to differences in assay methodologies and standardization. Institutions may also set up their ownreference ranges based on the particular populations that they serve, thus regional differences may occur. Consequently, values report-ed by individual laboratories may differ from those listed in this appendix.

    All values are given in conventional and SI units. However, cases where SI units have not been widely accepted, conventional unitsare used. In case of the heterogenous nature of the materials measured or uncertainty about the exact molecular weight of the com-pounds, SI measurements cannot be used so that mass per volume remains as the unit of concentration.

    Abbreviations:

    ACD, acid-citrate-dextrose; AMP, adenosine monophosphate; CEA, carcinoembryonic antigen; CHF, congestive heart failure; Cit,citrate; Cl, chlorine; CNS, central nervous system; CSF, cerebrospinal fluid; cyclic AMP, adenosine 3 ,5 -cyclic phosphate; EDTA,ethylenediaminetetraacetic acid; Hb, hemoglobin;HDL,high-density lipoprotein;Hep, heparin; LDL-C, low-density lipoprotein-cho-lesterol; MB, myoglobin; NaCit, sodium citrate; NAPA, N-acetylprocainomide; Ox, oxalate; RBC, red blood cell(s); RIA, radioim-munoassay; SD,standard deviation;WBC,white blood cell(s)

    References:Burtis CA, Ashwood ER. eds. Tietz textbook of clinical chemistry, 3rd ed. Philadelphia; WB Saunders, 1998.Childrens Hospital, St. Louis, The Department of Clinical Laboratories, High Density Lipoprotein L ipid Panel: Cholesterol, HDL, Cholesterol,

    LDL (calculated), Cholesterol, Total, Triglycerides, Parathyroid Hormone (PTH).Available athttp://webserver01.bjc.org/slch/pro/Professional.htm?http://webserver01.bjc.org/labtestguide/Lab%20Test%20Guidebook/slchlabsiteoutline.htm.Accessed April 20, 2004.

    Clinical chemistry laboratory:Reference range values in clinical chemistry. Professional services manual. Baltimore, Department of Pathology,University of Maryland Medical System, 1999.

    Harmening DM, ed. Hematologic values in chemical hematology and fundamentals of hemostasis, 2nd ed. Philadelphia: FA Davis, 1992.Laboratory Corporation of America, Erythrocyte Sedimentation Rate, Westergren. Available at

    http://www.labcorp.com/datasets/labcorp/html/chapter/mono/he005000.htm. Accessed April 20, 2004.Laboratory Corporation of America. Fecal Fat. Quantitative. Available at

    http://www.labcorp.com/datasets/labcorp/html/chapter/mono/sc008000.htm. Accessed April 20, 2004.National cholesterol education program:Report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Arch

    Intern Med1988;148:36-69.Triglyceride, high density lipoprotein and coronary heart disease. National Institute of Health Consensus Statement, NIH Consensus Development

    Conference, 1992;10(2).University of Texas Health Center at San Antonio. Neonatal Bilirubin. Available at http://labs-sec.uhs-sa.com/clinical_ext/dols/soprefrange.aps.

    Accessed April 20, 2004.University of Texas Medical Branch. Erythrocyte Sedimentation Rate, Wintrobe. Available at

    http://www.utmb.edu/lsg/LabSurvivalGuide/hem/Sedimentation_Rate.htm. Accessed April 20, 2004.University of Virginia Childrens Medical Center. Therapy Review: Warfarin (Coumadin).Pediatric Pharmacotherapy. January 1995;1(5):386.

    Available at http://www.people.virginia.edu/~smb4v/cmchome.html. Accessed April 20, 2004.Wafarin Therapy in Children Who Require Long-Term Total Parenteral Nutrition.Pediatrics [electronic article]. November 2003;112(5):386.

    Available at http://pediatrics.aappublications.org/cgi/content/full/112/5/e386. Accessed April 20, 2004.

    APP17 lab reference range values.qxd 8/13/05 1:45 PM Page APP 96

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    APP 97LA BORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI Units

    *Test values dependent on laboratory methods used.

    Acetaminophen, serum or

    plasma (Hep or

    EDTA)

    Thera peutic 1030 mcg/mL 66199 mcmol/L

    Toxic >200 mcg/mL >1324 mcmol/L

    AcetoneSerum

    Qua lita tive Nega tive Nega tive

    Qua ntita tive 0.32.0 mg/dL 0.050.34 mmol/L

    Urine

    Qua lita tive Nega tive Nega tive

    Acid hemolysis tes t (Ha m) 500 ng/mL >1805 nmol/LAmmonia

    P la sma (Hep) 933 mcmol/L 933 mcmol/L

    *Amylase

    S erum 27131 U/L 0.462.23 mcka t/L

    Urine 117 U/h 0.017-0.29 mcka t/h

    Amyla se:c rea tinine c lea ra nce 14% 0.010.04

    ratio

    APP17 lab reference range values.qxd 8/13/05 1:45 PM Page APP 97

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    APP 98 LABORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI UnitsTests Conventional Units SI UnitsTests Conventional Units SI UnitsTests Conventional Units SI Units

    *Test values dependent on laboratory methods used.Bilirubin data Source: https://labs-sec.uhs-sa.com/clinical_ext/dols/soprefrange.asp

    Androstened ione, serum

    Ma le 75205 ng/dL 2.67.2 nmol/L

    Fema le 85275 ng/dL 3.09.6 nmol/L

    Anion gap

    (Na [Cl + HCO 3]]) 716 mEq /L 716 mmol/L

    ([Na + K] [Cl + HCO 3]) 1020 mEq /L 1020 mmol/L1-Antitryps in, serum 78200 mg/dL 0.782.00 g/L

    Apolipoprotein A-1

    Ma le 94178 mg/dL 0.941.78 g/L

    Fema le 101199 mg/dL 1.011.99 g/L

    Apolipoprote in B

    Ma le 63133 mg/dL 0.631.33 g/L

    Fema le 60126 mg/dL 0.601.26 g/L

    Arsenic

    Whole blood (Hep) 0.22.3 mcg/dL 0.030.31 mcmol/L

    Chronic poisoning 1050 mcg/dL 1.336.65 mcmol/L

    Acute poisoning 60930 mcg/dL 7.98124 mcmol/L

    Urine, 24 h 550 mcg/d 0.070.67 mcmol/d

    Ascorbic a c id , pla sma (Ox, Hep, EDTA) 0.41.5 mg/dL 2385 mcmol/L

    *Aspa rta te a minotra nsfera se 1059 U/L (37 C) 0.171.00 -2 to + 3 ka t/L (37 C)

    (AS T, S G OT), s erum

    Base excess, blood (Hep) 2 to + 3 mEq/L 2 to + 3 mmol/L

    B ica rbona te, serum (venous) 2229 mEq /L 2229 mmol/L*B ilirub in

    B ilirubin, direct

    B irthdea th 0.00.4 mg/dL

    Bilirubin, total

    B irth1 da y 1.06.0 mg/dL

    12 da ys 6.07.5 mg/dL

    25 da ys 4.013.5 mg/dL

    5 da ysdea th 0.21.2 mg/dL

    Tota l bilirubin, neo nat a l

    B irth1 da y 1.06.0 mg/dL

    12 da ys 6.07.5 mg/dL

    25 da ys 4.013.5 mg/dL

    5 da ys1 month 0.01.8 mg/dL

    1 monthdea th 0.01.8 mg/dLBo ne ma rrow , differential cell count

    Adult

    Undifferentia ted cells 01% 00.01

    Myelobla s t 02% 00.02

    P romyelocyte 0-4% 00.04

    Myelocytes

    Neutrophilic 520% 0.050.20

    Eosinophilic 03% 00.03

    B a sophilic 01% 00.01

    Metamyeolocytes and bands

    Neutrophilic 535% 0.050.35

    Eosinophilic 05% 00.05

    B a sophilic 01% 00.01

    S egmented neutrophils 515% 0.050.15

    P ronormobla s t 01.5% 00.015

    B a sophilic normobla s t 05% 00.05P olychroma tophilic normobla s t 530% 0.050.30

    Orthochroma tic normobla s t 510% 0.050.10

    Lymphocytes 1020% 0.100.20

    P la sma cells 02% 00.02

    Monocytes 05% 00.05

    CA-125, serum

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    APP 99LA BORATORY REFERENCE RANGE VALUES

    *Test values dependent on laboratory methods used.

    CA 19-9, serum 20% tota l Hb >0.20 HbCO fra c tion

    Letha l >50% tota l Hb >0.5 HbCO fra c tion

    Ca rotene, serum 1085 mcg/dL 0.191.58 mcmol/L

    Ca techolamines, plas ma

    (EDTA)

    Dopa mine < 30 pg/mL

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    APP 100 LABORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI Units

    *Test values dependent on laboratory methods used.

    *Cell counts, adult (continued from previous page)

    Reticulocytes 0.51.5% RB C s 0.0050.015 of RB Cs

    24,00084,000/mcL 2484 109/L

    Cells , CS F 010 lymphocytes/mm3 0-10 lymp hoc yte s/mm3

    0 RB C/mm3 0 RB C/mm3

    Cerulopla smin, serum 2060 mg/dL 0.20.6 g/LChloramphenicol, serum or

    plasma (Hep or

    EDTA); trough

    Thera peutic 1025 mcg/mL 3177 mcmol/L

    Toxic >25 mcg/mL >77 mcmol/L

    Chloride

    S erum or pla sma (Hep) 98107 mmol/L 98107 mmol/L

    S wea t

    Norma l 535 mmol/L 535 mmol/L

    Cys tic fibros is 60200 mmol/L 60200 mmol/L

    Urine, 24 h (vary greatly with

    Cl intake)

    Infa nt 210 mmol/24 h 210 mmol/24h

    Child 1540 mmol/24 h 1540 mmol/24h

    Adult 110250 mmol/24 h 110250 mmol/24 h

    CS F 118132 mmol/L (20 mmol/L 118132 mmol/L (20 mmol/L

    higher tha n serum) higher tha n serum)

    Choleste rol, se rum

    Adult desira ble

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    APP 101LA BORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI Units

    **Test values dependent on laboratory methods used.Test values dependent on patients race.

    Complement components (continued from p revious page)

    Tota l complement deca y ra te 1020% Fra ction deca y ra te: 0.100.20

    (func tiona l), pla sma Defic iency: >50% >0.50

    (EDTA)

    C 1q , serum 14.922.1 mg/dL 149221 mg/L

    C 1r, serum 2.510.0 mg/dL 25100 mg/LC 1s(C1 estera se), serum 5.010.0 mg/dL 50100 mg/L

    C 2, serum 1.63.6 mg/dL 1636 mg/L

    C 3, serum 90180 mg/dL 0.91.8 g/L

    C 4, serum 1040 mg/dL 0.1-0.4 g/L

    C 5, serum 5.511.3 mg/dL 55113 mg/L

    C 6, serum 17.923.9 mg/dL 179239 mg/L

    C 7, serum 2.77.4 mg/dL 2774 mg/L

    C 8, serum 4.910.6 mg/dL 49106 mg/L

    C 9, serum 3.39.5 mg/dL 3395 mg/L

    Coombs test

    Direc t Nega tive Nega tive

    Indirect Nega tive Nega tive

    Copper

    Serum

    Ma le 70140 mcg/dL 1122 mcmol/L

    Fema le 80155 mcg/dL 1324 mcmol/L

    Urine 335 mcg/24 h 0.050.55 mcmol/24 h

    Corpuscular values of

    erythrocyte s (values

    are for adults; in

    children, va lues vary

    with age)

    Mea n corpuscula r hemoglobin (MCH) 2731 pg 0.420.48 fmol

    Mea n corpuscula r hemoglobin 3337 g/dL 330370 g/L

    conc entration (MCHC)

    Me a n c o rp us c ula r vo lum e (MC V) Ma le 8094 m cm3 8094 fL

    Female 8199 mcm3 8199 fL

    Cortisol, serum

    P las ma (Hep, EDTA, Ox)

    8 AM 523 mcg/dL 138635 nmol/L

    4 P M 316 mcg/dL 83441 nmol/L10 P M

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    APP 102 LABORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI Units

    *Test values dependent on laboratory methods used.Actual therapeutic range should be adjusted for individual patient.

    Cyanide

    Serum

    Nonsmokers 0.004 mg/L 0.15 mcmol/L

    S mokers 0.006 mg/L 0.23 mcmol/L

    Nitropruss ide thera py 0.010.06 mg/L 0.382.30 mcmol/L

    Toxic >0.1 mg/L >3.84 mcmol/LWhole b lood (Ox)

    Nonsmokers 0.016 mg/L 0.61 mcmol/L

    S mokers 0.041 mg/L 1.57 mcmol/L

    Nitropruss ide thera py 0.050.5 mg/L 1.9219.20 mcmol/L

    Toxic >1 mg/L >38.40 mcmol/L

    Cy clic AMP

    P las ma (EDTA)

    Ma le 4.68.6 ng/mL 1426 nmol/L

    Fema le 4.37.6 ng/mL 1323 nmol/L

    Urine, 24 h 0.33.6 mg/d 1.010.9 mcmol/d or

    or 0.292.1 mg/g crea tinine 100723 mcmol/mol c rea tinine

    C ys tine or cysteine, urine, Nega tive Nega tive

    qualitative

    *C-P eptide, serum 0.781.89 ng/mL 0.260.62 nmol/L

    C -Rea c tive protein, serum 1500 nmol/L

    Diazepa m, serum or plas ma

    (Hep or EDTA);

    trough

    Thera peutic 1001000 ng/mL 0.353.51 mcmol/L

    Toxic >5000 ng/mL >17.55 mcmol/L

    Digitoxin, s erum or plas ma

    (Hep or EDTA); 7.8 h

    after dose

    Thera peutic 2035 ng/mL 2646 nmol/L

    Toxic >45 ng/mL >59 nmol/L

    Digo xin, serum or plas ma

    (Hep or EDTA); 12 h

    after doseTherap eutic

    C HF 0.81.5 ng/mL 1.01.9 nmol/L

    Arrhythmia s 1.52.0 ng/mL 1.92.6 nmol/L

    Toxic

    Adult >2.5 ng/mL >3.2 nmol/L

    C hild >3.0 ng/mL >3.8 nmol/L

    APP17 lab reference range values.qxd 8/13/05 1:45 PM Page APP 102

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    APP 103LA BORATORY REFERENCE RANGE VALUES

    *Test values dependent on laboratory methods used.Reference values vary from laboratory to laboratory, but are generally found within the range of 57 g/d. It should be noted that children, espe-

    cially infants, cannot ingest the 100 g/d of fat that is suggested for the test. Therefore, a fat retention coefficient is determined by measuring thedifference between ingested fat and fecal fat, and expressing that difference as a percentage. The figure, called the fat retention coefficient, is95% or greater in healthy children and adults. A low value indicates steatorrhea.http://www.labcorp.com/datasets/labcorp/html/chapter/mono/sc008000.htm

    Fatty acids include a mixture of different aliphatic acids of varying molecular weight; a mean molecular weight of 284 daltons has beenassumed.

    Disopyramide, serum or plasma

    (Hep or EDTA);

    trough

    Thera peutic a rrhythmia s

    Atria l 2.83.2 mcg/mL 8.39.4 mcmol/L

    Ventricula r 3.37.5 mcg/mL 9.722 mcmol/LToxic >7 mcg/mL >20.7 mcmol/L

    Doxepin, serum or plasma

    (Hep or EDTA);

    trough (12 h after

    dose)

    Thera peutic 150250 ng/mL 537895 nmol/L

    Toxic >500 ng/mL >1790 nmol/L

    *Estradiol, serum

    Adult

    Ma le 1050 pg/mL 37-184 pmol/L

    Fema le Va ries w ith menstrua l cycle

    Ethanol (alcohol), whole blood (Ox) or

    serum

    Depress ion of CNS >100 mg/dL >21.7 mmol/L

    Fa ta lities reported >400 mg/dL >86.8 mmol/L

    Ethosuximide, serum or plasma

    (Hep or EDTA);

    trough

    Thera peutic 40100 mcg/mL 283708 mcmol/L

    Toxic >150 mcg/mL >1062 mcmol/L

    Euglobin lys is No lys is in 2 h No lys is in 2 h

    -Fetoprotein (AFP ), serum

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    APP 104 LABORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI UnitsTests Conventional Units SI UnitsTests Conventional Units SI Units

    *Test values dependent on laboratory methods used.

    Follicle-stimulating hormone (continued from previous page)

    Mid-cycle 617 mIU/mL 617 IU/L

    Lutea l pha se 19 mIU/mL 19 IU/L

    P os tmenopa usa l 19100 mIU/mL 19100 IU/L

    *Free thyroxine index (FTI), serum 4.213 4.213

    G a strin, serum

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    APP 105LA BORATORY REFERENCE RANGE VALUES

    *Test values dependent on laboratory methods used.If the triglyceride value is >400 mg/dL, the LDL calculation is invalid.

    http://webserver01.bjc.org/slch/pro/Professional.htm?http://webserver01.bjc.org/labtestguide/Lab%20Test%20Guidebook/slchlabsiteoneline.htm

    HDL-Lipid Panel (continued)

    borderline 200239 mg/dL

    high >240 mg/dL

    Tryg lyce rides

    desira ble 200 mg/dL

    Hematocrit

    Ma les 4252% 0.420.52

    Fema les 3747% 0.370.47

    Newborn 5365% 0.530.65

    Children (va ries w ith a ge) 3043% 0.300.43

    Hemoglobin (Hb)

    Ma les 14.018.0 g/dL 2.172.79 mmol/L

    Fema les 12.016.0 g/dL 1.862.48 mmol/L

    Newborn 17.023.0 g/dL 2.643.57 mmol/L

    Children (va ries w ith a ge) 11.216.5 g/dL 1.742.56 mmol/L

    Hemoglobin, fetal 1 y old:

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    APP 106 LABORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI UnitsTests Conventional Units SI UnitsTests Conventional Units SI UnitsTests Conventional Units SI Units

    Iron s aturation, s erum

    Ma le 2050% 0.20.5

    Fema le 1550% 0.150.5

    17-Ketosteroids, urine

    Ma les 1025 mg/24 h 3887 mcmol/24 h

    Fema les 614 mg/24 h 2152 mcmol/24 h(decrea ses w ith a ge) (decrea ses w ith a ge)

    L-Lactate

    Plasma (NaF)

    Venous 4.519.8 mg/dL 0.52.2 mmol/L

    Arteria l 4.514.4 mg/dL 0.51.6 mmol/L

    Whole blood (Hep), a t be d res t

    Venous 8.115.3 mg/dL 0.91.7 mmol/L

    Arteria l

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    APP 107LA BORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI UnitsTests Conventional Units SI Units

    *Test values dependent on laboratory methods used.

    *Luteinizing hormone (LH),

    serum or

    plasma (Hep)

    Ma le 1.247.8 mIU/mL 1.247.8 IU/L

    Female

    Follicula r pha se 1.6815.0 mIU/mL 1.6815.0 IU/LMid-cyc le pea k 21.956.6 mIU/mL 21.956.6 IU/L

    Lutea l pha se 0.6116.3 mIU/mL 0.6116.3 IU/L

    P ostmenopa usa l 14.252.5 mIU/mL 14.252.3 IU/L

    Magnesium

    S erum 1.32.1 mEq /L 0.651.07 mmol/L

    1.62.6 mg/dL 1626 mg/L

    Urine 6.010.0 mEq /24 h 3.05.0 mmol/24 h

    Mercury

    Whole blood (EDTA) 0.659 mcg/L

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    APP 108 LABORATORY REFERENCE RANGE VALUES

    *Test values dependent on laboratory methods used.

    Oxygen, blood

    Ca pa city 1624 vol% (va ries w ith 7.1410.7 mmol/L (va ries w ith

    hemoglobin) hemoglobin)

    Content

    Arteria l 1523 vol% 6.6910.3 mmol/L

    Venous 1016 vol% 4.467.14 mmol/LSaturation

    Arteria l a nd ca pilla ry 9598% of ca pa c ity 0.950.98 of ca pa c ity

    Venous 6085% of ca pa c ity 0.600.85 of ca pa city

    Tension

    pO 2 a rteria l a nd ca pilla ry 83108 mmHg 11.114.4 kP a

    Venous 3545 mmHg 4.66.0 kP a

    P 50, blood 2529 mmHg (a djus ted to pH 7.4) 3.333.86 kP a

    P a rtia l thrombopla s tin time 44 mcmol/L

    pH

    B lood, a rteria l 7.357.45 7.357.45

    Urine 4.68.0 (depends on diet) S a me

    P hena ce tin, plas ma (EDTA)

    Thera peutic 130 mcg/mL 6167 mcmol/L

    Toxic 50250 mcg/mL 2791395 mcmol/L

    Phenobarbital, serum or plasma

    (Hep or EDTA); trough

    Thera peutic 1540 mcg/mL 65172 mcmol/L

    Toxic

    S lowness , a ta xia , nys ta gmus 3580 mcg/mL 151345 mcmol/L

    Coma w ith reflexes 65117 mcg/mL 280504 mcmol/L

    Coma w ithout reflexes >100 mcg/mL >430 mcmol/L

    P henolsulfonphtha lein (P SP ) excretion, 2851% in 15 min 0.280.51 in 15 min

    urine 1324% in 30 min 0.130.24 in 30 min

    917% in 60 min 0.090.17 in 60 min310% in 2 h 0.030.10 in 2 h

    (After injection of 1 mL P SP (After injec tion of 1 mL P SP

    intra venously) intra venous ly)

    P henyla la nine, serum 0.81.8 mg/dL 48109 mcmol/L

    Phenytoin, serum or plasma

    (Hep or EDTA); trough

    Thera peutic 1020 mcg/mL 4079 mcmol/L

    Toxic >20 mcg/mL >79 mcmol/L

    *Phos phatas e, a cid, prosta tic, s erum

    ra dioimmunoa ssa y

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    APP 109LA BORATORY REFERENCE RANGE VALUES

    *Test values dependent on laboratory methods used.

    Porphyrins, urine

    C oproporphyrin 34230 mcg/24 h 52351 nmol/24 h

    Uroporphyrin 2752 mcg/24 h 3263 nmol/24 h

    Po tass ium, plas ma (Hep)

    Ma les 3.54.5 mEq /L 3.54.5 mmol/L

    Fema les 3.44.4 mEq /L 3.44.4 mmol/LPotassium

    Serum

    Premature

    Cord 5.010.2 mEq /L 5.010.2 mmol/L

    48 h 3.06.0 mEq /L 3.06.0 mmol/L

    Newborn, cord 5.612.0 mEq /L 5.612.0 mmol/L

    Newborn 3.75.9 mEq /L 3.75.9 mmol/L

    Infa nt 4.15.3 mEq /L 4.15.3 mmol/L

    Child 3.44.7 mEq /L 3.44.7 mmol/L

    Adult 3.55.1 mEq /L 3.55.1 mmol/L

    Urine, 24 h 25125 mEq /d, va ries w ith d iet 25125 mmol/d; va ries w ith d iet

    C S F 70% of pla sma level or 2.53.2 0.70 of pla sma level or 2.53.2

    mEq /L; rise s w ith mmo l/L; rise s with

    pla sma hyperosmola lity pla sma hyperosmola lity

    P rea lbumin (tra ns thyretin), serum 1040 mg/dL 100400 mg/L

    Primidone, serum or plasma

    (Hep or EDTA); trough

    Thera peutic 512 mcg/mL 2355 mcmol/L

    Toxic >15 mcg/mL >69 mcmol/L

    Proca inamide, serum or plasma

    (Hep or EDTA); trough

    Thera peutic 410 mcg/mL 1742 mcmol/L

    Toxic (a ls o c ons id er effect of >1012 mcg /mL 4251 mc mo l/L

    metabolite, i.e., NAPA)

    *Progesterone, serum

    Adult

    Ma le 1397 ng/dL 0.43.1 nmol/L

    Female

    Follicula r pha se 1570 ng/dL 0.52.2 nmol/L

    Lutea l pha se 2002500 ng/dL 6.479.5 nmol/L

    P regna ncy Va ries w ith gesta tiona l w eek*Prolactin, serum

    Ma les 2.515.0 ng/mL 2.515.0 mcg/L

    Fema les 2.519.0 ng/mL 2.519.0 mcg/L

    P ropoxy phene , pla sm a (EDTA)

    Thera peutic 0.10.4 mcg/mL 0.31.2 mcmol/L

    Toxic >0.5 mcg/mL >1.5 mcmol/L

    Propranolol, serum or plasma

    (Hep or EDTA); trough

    Thera peutic 50100 ng/mL 193386 nmol/L

    *P rosta te-spec ific antigen (P SA),

    serum

    Ma le

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    APP 110 LABORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI Units

    NOTE: INR=[(Patient PT)/(Normal PT)] *ISI where ISI is the international sensitivity index, a value provided by the reagent manufacturer.NOTE: target therapeutic range (international normalized ratio) of 2.03.0. http://pediatrics.aappublications.org/cgi/content/full/112/5/e386NOTE: The American College of Chest Physicians has recommended a therapeutic INR range for adults of 2.03.0, except in patients with mechani-

    cal cardiac valves who should have an INR of 2.53.5. 1target INR range of 2.63.8 for children with heart disease and a slightly lower range of2.13.3 for treating children with established venous thrombosis. Clinicians at Torontos Hospital for Sick Children used an INR range of 2.03.0initially but later found that a lower target of 1.31.8 was as effective and resulted in no bleeding complications.http://www.healthsystem.virginia.edu/internet/pediatrics/pharma-news/jan95.pdfNOTE: The recommended therapeutic target for the treatment and prevention of venous thromboembolisms and pulmonary embolisms in an INR of2.5 with a range between 2.03.0, and children with mechanical prosthetic heart valves have a recommended therapeutic INR range of 3.0 INRrange between 2.53.5. Evaluate at that time. http://www.warfarinfo.com/pediatrics.htm

    *Test values dependent on laboratory methods used.#http://www.labcorp.com/datasets/labcorp/html/chapter/mono/he005000.htm;http://www.utmb.edu/lsg/LabSurvivalGuide/hem/Sedimentation_Rate.htm

    P rothrombin consumption >20 sec >20 sec

    Prothrombin time-international normalized ratio (see NOTES below)

    INR: birth6 mo 1.01.6

    INR: 6 moa dult 0.91.2

    P rotoporphyrin, tota l, WB 18 mcmol/L

    Sa licylates, s erum o r plas ma

    (Hep or EDTA); trough

    Thera peutic 150300 mcg/mL 1.092.17 mmol/L

    Toxic >500 mcg/mL 3.62 mm ol/L#Sedimentation rate, erythrocyte

    Westergren

    Ma le: 050 y 015 mm/h

    Ma le: >50 y 020 mm/h

    Fema le: 050 y 020 mm/h

    Fema le: >50 y 030 mm/h

    Wintrobe

    Ma les

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    APP 111LA BORATORY REFERENCE RANGE VALUES

    *Test values dependent on laboratory methods used.

    Theo phylline, s erum or plas ma

    (Hep or EDTA)

    Therap eutic

    B ronchodila tor 820 mcg/mL 44111 mcmol/L

    P rem. a pnea 613 mcg/mL 3372 mcmol/L

    Toxic >20 mcg/mL >110 mcmol/LThiocya nat e

    S erum o r plas ma (EDTA)

    Nonsmoker 14 mcg/mL 1769 mcmol/L

    S moker 312 mcg/mL 52206 mcmol/L

    Thera peutic a fter 629 mcg/mL 103499 mcmol/L

    nitroprusside infusion

    Urine

    Nonsmoker 14 mg/d 1769 mcmol/d

    S moker 717 mg/d 120292 mcmol/d

    Thiopenta l, se rum or plas ma

    (Hep or EDTA); trough

    Hypnotic 1.05.0 mcg/mL 4.120.7 mcmol/L

    Coma 30100 mcg/mL 124413 mcmol/L

    Anesthes ia 7130 mcg/mL 29536 mcmol/L

    Toxic concentra tion >10 mcg/mL >41 mcmol/L

    *Thyroid-s timula ting hormone 0.44.2 mcU/mL 0.44.2 mU/L

    (TS H), serum

    Thyroxine serum 512 mcg/dL (va ries w ith a ge, 65155 nmol/L (va ires w ith a ge,

    higher in children a nd higher in children a nd

    pregna nt w omen) pregna nt women)

    *Thyroxine, free, serum 0.82.7 ng/dL 10.335 pmol/L

    Thyroxine binding globulin 1.23.0 mg/dL 1230 mg/L

    (TBG), serum

    Tobra mycin, se rum o r plas ma

    (Hep or EDTA)

    Therap eutic

    Pea k

    Less severe infec tion 58 mcg/mL 1117 mcmol/L

    S evere infection 810 mcg/mL 1721 mcmol/L

    Trough

    Less severe infec tion

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    LABORATORY REFERENCE RANGE VALUES

    Tests Conventional Units SI Units

    Uric Acid (continued)

    C hild 2.05.5 mg/dL 0.120.32 mmol/L

    Urine 250750 mg/24 h 1.484.43 mmol/24 h

    (w ith norma l d iet) (w ith norma l d iet)

    Urobilinogen, urine 0.10.8 Ehrlich unit/2 h 0.1-0.8 Eu/2h

    0.54.0 Eu/d 0.54.0 Eu/dValproic a cid, s erum or plas ma

    (Hep or EDTA); trough

    Thera peutic 50100 mcg/mL 347693 mcmol/L

    Toxic >100 mcg/mL >693 mcmol/L

    Vancomycin, serum or plasma

    (Hep or EDTA);

    Therap eutic

    P ea k 2040 mcg/mL 1428 mcmol/L

    Trough 510 mcg/mL 37 mcmol/L

    Toxic >80100 mcg/mL >5569 mcmol/L

    Va nillylma ndelic a c id (VMA), 1.46.5 mg/24 h 733 mcmol/d

    urine (4-hydroxy-3-

    methoxymandelic ac id)

    Viscos ity, serum 1.001.24 cP 1.001.24 cP

    Vita min A, serum 3080 mcg/dL 1.052.8 mcmol/L

    Vita min B 12, serum 110800 pg/mL 81590 pmol/L

    Vitamin E, s erum

    Norma l 518 mcg/mL 1242 mcmol/L

    Thera peutic 3050 mcg/mL 69.6116 mcmol/L

    Zinc , serum 70120 mcg/dL 10.718.4 mcmol/L

    APP 112

    *Test values dependent on laboratory methods used.

    APP17 lab reference range values.qxd 8/13/05 1:45 PM Page APP 112