lara vojnov, phd department of pathology and laboratory medicine university of wisconsin-madison
DESCRIPTION
The majority of freshly sorted SIV-specific CD8 + T cells cannot suppress viral replication in SIV-infected macrophages. Lara Vojnov, PhD Department of Pathology and Laboratory Medicine University of Wisconsin-Madison Madison, WI, USA. Evidence of HIV/SIV infection of macrophages. - PowerPoint PPT PresentationTRANSCRIPT
The majority of freshly sorted SIV-specific CD8+ T cells cannot suppress viral replication in SIV-
infected macrophagesLara Vojnov, PhD
Department of Pathology and Laboratory MedicineUniversity of Wisconsin-Madison
Madison, WI, USA
Evidence of HIV/SIV infection of macrophages
Zhang et al. Science 1999
Veazey et al. Science 1998
In vivo SIVmac239 infection of macrophages in intestinal
lymphoid nodule
CD68+ macrophages comprise 10% of the
SIVmac251 cell population in vivo
Evidence of HIV/SIV infection of macrophages
Zhang et al. Science 1999
Veazey et al. Science 1998
PNAS 2001
SAMHD1 inhibits HIV infection of macrophages without Vpx
Hypothesis
Macrophages play an important role in HIV/SIV infection as a
viral reservoir resistant to CTL-mediated lysis.
SIV-specific CD8+ T cells suppress viral replication in SIV-infected CD4+ T cells
MHC matchedinfected targets
MHC mismatchedinfected targets
SIV-specific CD8+ T cells poorly suppress viral replication in SIV-infected macrophages
MHC matchedinfected targets
MHC mismatchedinfected targets
CD4+ T cells vs macrophages
SIV-specific CD8+ T cells poorly suppress viral replication in SIV-infected macrophages
32% 88%
SIV-specific CD8+ T cells poorly suppress viral replication in SIV-infected macrophages
3% 30%
Bulk CD8+ T cells suppress viral replication in SIV-infected CD4+ T cells
Bulk CD8+ T cells poorly suppress viral replication in SIV-infected macrophages
Time-course of SIV-infected elite controllers
AcknowledgementsNational Institutes of Health
Jorge AlmeidaDanny Douek
NEPRCR. Paul Johnson
FIOCRUZ – Rio De JaneiroMyrna Bonaldo
Marlon Veloso de SantanaPatricia Costa Neves
Ricardo Galler
University of Wisconsin-MadisonMauricio MartinsAlexander Bean
Jonah SachaHolly Kolar
Nancy WilsonBenjamin BurwitzDavid O’Connor
University of MiamiDavid WatkinsAnn Dauphin
Mario Stevenson