Cardiovascular Disease [70-80%]

atherosclerosis [the disease of the arteries]

endothelial dysfunction

Laszlo G. MeszarosDept. Animal PhysiologyUniv. of Kaposvar, HungaryArgina NutraceuticalsHungary

Nutraceutical therapy

“You’re as old as your arteries…”

1. AS is responsible for more death than any other disease.

2. Not only deadly infarct and stroke, but overall well-being.

3. 6 out of 10 deadliest risk factors directly relate to AS.

4. No. 1 “risk factor” of AS is diet and life-style.

5. AS is a degenerative disease.

AS is a degenerative disease

Error accumulation &Epigenetical changes

are likelycaused by diet and life style

Error accumulation &Epigenetical changes

are likelycaused by diet and life style

Degenerative diseases:

AS,Most types of cancer,Metabolic disease,Type-2 diabetes,Alzheimer’s,(Osteo)arthritis,…

Tomiyama H et al.: Hypertens. Res. 2004, 27:465)

Who’s who?

Grandpa and grandson somewhere in Africa.Can you guess?

It’s easy, when you look at their faces…

Santos PC et al.: Ethnicity and arterial stiffness in Brazil, Am. J. Hypertens, 2011, 24:278)

So, there is hope… (age vs. disease)

Error accumulation &Epigenetical changes

are MORE THAN LIKELYcaused by diet and life style

Error accumulation &Epigenetical changes

are MORE THAN LIKELYcaused by diet and life style

Why diet? Why physical inactivity?

Physical inactivity

Activity: beneficial effect on arterial stiffnessInactivity → obesity:dyslipidemia, metabolic syndrome,abdominal (visceral) fat as adysfunctional “immune organ”that produces inflammatorycytokines

Diet (in “developed” countries):

Junk food (in every sense),AdditivesB-type malnutrition

Waist circumference correlatesstronger with CVD and MD thanBMI.

B-Type Malnutrition

% of RDA – USDA, 2004

Vitamin: A E C B1 B2 B4 B6Intake: 45 32 63 68 69 76 46

Only 15% of the population in the US consumes the recommended amounts of fruits and vegetables daily.More than 70% is vitamin D deficient. More than 90% is vitamin K2 deficient.Ames’s “Triage” theory

Comments: RDA values are most likely underestimated… (vitamin D) “Extra” vitamins: omega 3, flavonoids, other phytonutrients…

B-Type Malnutrition

Reminder…

Problems at the beginning… (chance to treat the initial cause?)

I/1 eNOS decreases with age

I/2 NO reacts with free radicals: NO + O2

- = ONOO-

I/3 ADMA that competes with L-arg (Arginine-paradox)

II LDL-ch is VERY sensitive to oxidation by free radicals

So, one thing is for sure: we needefficient antioxidants.

And what else?

Chance to treat the cause? An example: resveratrolJust look for the white arrows…

(reviewing the literature)

9 papers on FMD improvements by resveratrol (1921 papers all together on resveratrol benefits)1 paper suggesting Q10 supplementation to decrease Aix11 papers to show that grape polyphenols (antho- and procyanidines) improve FMD3 papers on vitamin K2 decreasing vascular calcification3 papers on plasma vitamin D decreasing arterial stiffness21 papers to show that vitamin D improves other circulation parameters (coronary flow, for instance)

How about arterial function?

2 x 1 daily placebo or 150 mg grape seed procyanidines + 60 mg Aronia melanocarpa anthocyanidines; test at the beginning and after 3 months

Our results…

PWV (m/s) Treated group (n=11) 0 3

12.41±1.13 9.74±0.82** significant at P < 0.05

- Also significant reduction in systolic BP- Some decrease in LDL-ch (n=7)

Our results…

- Also significant reduction in BP- Significant increase in HDL-ch (n=5)- Significant improvement in EF

Regimen 1: 2 x 1 daily 150 mg GSE pro- + 60 mg Am anthocyanidines + 10 mg resveratrol + 50 mg Q10 (water soluble)

Regimen 2: regimen 1 + (2x1) 50 µg vitamin K2 and 1000 IU of vitamin D3)

So, it seems that…

Thanks for listening…

Or take vitamins and dietary supplements

We have two choices: