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    David PrestiDepartment of Molecular and Cell Biology

    University of California, Berkeley

    Summer 2008

    Topics

    brain and nervous system organization atoms, molecules, proteins, lipids, membranes

    cells, DNA, genes neurons, ion channels, nerve signaling

    synapse, neurotransmitters, neural circuits molecular pharmacology, drugs

    seizures brain imaging (PET, fMRI, MEG, etc)

    brain development sensation and perception

    Topics

    vision audition, music taste, smell

    somatosensory / tactile movement, paralysis

    biological rhythms, sleep, dreaming learning, memory

    language mental disorders: depression, psychosis, etc

    mind, consciousness

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    Textbooks

    An Introduction to Brain and Behavior

    by Bryan Kolb And Ian Whishaw2nd edition - 2006

    The Double Helixby James Watson - 1968Norton Critical Edition

    edited by Gunther Stent - 1980

    Course Grade

    Exams: Two Midterm Exams (online)

    Final Exam (proctored)

    Homeworks: neuroscience in the news (one)

    Double Helixessay composing exam questions

    neuroscience in the news (two)

    Online Discussion Forum participation

    2001: A SPACE ODYSSEY

    (1968)

    directed by Stanley Kubrickwritten by Stanley Kubrick (1928-1999)

    and Arthur C. Clarke (1917-2008)

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    Hominid Evolution

    hominid = human-like animal

    includes modern humans and recent

    (circa past 4 million years)

    human ancestors

    a timeline of hominid evolution

    millions of years agoFigure 1-12

    time spansare

    approximate

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    Hominid Evolution

    genus Australopithecus

    various species have been described:

    A. robustus, A. africanus,

    A. afarensis, A. aethiopicus

    circa 4 million years to 1 million years ago

    Hominid Evolution

    genus Homo

    Homo habilis

    circa 2 million years to 1.5 million years ago

    Homo erectus

    circa 1.6 million years to 200,000 years ago

    Homo sapiens

    modern humans

    circa 200,000 years ago

    to the present

    only extant hominid species

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    Homo neanderthalensis

    parallel evolutionary branch of the genus Homo

    circa 300,000 to 30,000 years ago

    ritual

    burial of dead

    pet animals

    music

    ancient music? - circa 50,000 years ago

    portion of what appears to be a flute made

    from bear bone by Homo neanderthalensisFigure 9-1

    brainsizecubic

    centimeters(cc)

    Figure 1-12

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    Killing of conspecifics

    hominid human ancestors

    ~ 4 million years ago

    human deaths due to violent conflictin the 20th century

    ~160,000,000

    I refuse to accept the cynical notion that nation after nationmust spiral down a militaristic stairway....I believe that unarmedtruth and unconditional love will have the final word in reality.

    Martin Luther King (1929-1968)Nobel Peace Prize acceptance speech - 1964

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    Does HAL

    have amind?

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    What is Mind?collection of mental states

    internal, subjective experiences:thoughts

    feelings

    perceptions

    awareness / consciousness

    Reading associated with this lecture:

    An Introduction to Brain and BehaviorChapter 1

    begin readingThe Double Helix