lecture 11 – second messengers v – map kinase & phospholipase d signalling

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Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modiﬁed -13F

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Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. CSB Fig 02:01 Cell signalling pathways. - PowerPoint PPT Presentation

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Page 1: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

Page 2: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

CSB Fig 02:01 Cell signalling pathways

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Page 3: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Transducers Second Messengers II

1. MAP kinase signaling• ERK pathway• JNK pathway• p38 pathway

2. Phospholipase D signaling3. Shingomylin Signaling

Page 4: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:61 ROS microdomains

Page 5: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:62 ERK signalling

Page 6: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:63 JNK signalling

Page 7: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:64 NF-kB, IkB, and IKK structure

Page 8: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:65 NF-kB activation

Page 9: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:66 Toll receptor signalling

Page 10: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:67 Virus recognition

Page 11: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:68 PLD isoforms

Page 12: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:69 PLD signalling

Page 13: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:70 Sphingolipid metabolism

Page 14: Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:71 Sphingomyelin signalling

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