LECTURE 8C

6 March 2015MINERALS

MINOR MINERALS IN HEALTH AND DISEASE

IDATME

INGESTION-oral, tube feeding, IV

DIGESTION- none

ABSORPTION- active, facilitated and occasionally simple

TRANSPORT-FREE – rare- e.g. iodine

-BOUND - very common- -mostly protein e.g. iodine, iron

IDATME continued

METABOLISM-minerals in = minerals out -participate as co-factors for various enzymes

EXCRETION – definitely in urine, faeces, sweat, saliva is questionable

MINERAL SUPPLEMENTS

REQUIRED IF:

A) inadequate dietary supply of minor minerals relative to need

B) in disease in general, a monitoring of minor minerals shows requirement

USE OF FUNCTIONAL FOODS AND NUTRACEUTICAL TO

SUPPLEMENT MINOR MINERALS

example- bread

MINOR MINERALS IN HEALTH AND DISEASE

ATHEROSCLEROSIS

SELENIUM- part of an antioxidant protein

antioxidant protein reduces free radicals and oxidant damage due to free

radicals

R-COO.

MINOR MINERALS IN HEALTH AND DISEASE CONTINUED

tooth decay- fluoride deficiency

MINOR MINERALS IN HEALTH AND DISEASE CONTINUED

fluoride prevents tooth decay but too

much fluoride

gives mottled

teeth

MINOR MINERALS IN HEALTH AND

DISEASE CONTINUED

anemia-may be due to lack of iron in diet

MINOR MINERALS IN HEALTH AND DISEASE CONTINUED

absorption

villi

MINOR MINERALS IN HEALTH AND DISEASE CONTINUED

COELIAC DISEASE

malabsorption

lack of iron-get anemia

MINOR MINERALS IN HEALTH AND

DISEASE CONTINUED

Alcoholism- low zinc due to increased

urinary output and

malabsorption of zinc

- malabsorption due to poor

fat breakdown due to

poor liver function.

MINOR MINERALS IN HEALTH AND

DISEASE CONTINUED

BURNS- loss of zinc with albumin

(zinc is bound to albumin) is a

possible explanation for zinc

loss

MINOR MINERALS IN HEALTH AND

DISEASE CONTINUED

Diabetes

chromium deficient persons supplement with chromium and get better

glucose transport

MINOR MINERALS IN HEALTH

AND DISEASE CONTINUED

Rheumatoid arthritis

low dietary intakes of zinc and selenium

WHAT IS NEW IN MINOR MINERAL RESEARCH ?

Björkblom B, Adilbayeva A, Maple-Grødem J, Piston D, Ökvist M, Xu XM, Brede C, Larsen JP, Møller SG.

Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.

J Biol Chem. 2013 Aug 2;288(31):22809-20. doi: 10.1074/jbc.M113.482091. Epub 2013 Jun 21.

Protein in brain called DJ-1 binds copper to reduce early onset Parkinson’s disease- this effect is lost with certain mutations

One final thought for today

Integration of nutrients into package

i.e. macronutrient metabolism and the goods (vitamins and minerals and water to help

with that macronutrient metabolism)- please think of examples