lecture questions. hypothesis? lactose persistence evolved by strong natural selection in african...

LECTURE QUESTIONS

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LECTURE QUESTIONS

Page 4: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Page 5: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Hypothesis?Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Methods?

They conducted a genotype by phenotype association study in 470 Tanzanians, Kenyans and Sudanese

They also tested if the novel association significantly enhance transcriptionfrom the LCT promoter in vitro.

Page 6: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Page 7: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Frequency of lactase persistence in East African populations

Page 8: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Are the SNPs associated with lactase persistence in Africans?

LP = lactase persistence

LIP = lactase intermediate persistence

LNP = lactase non-persistence

Page 9: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Are the SNPs associated with lactase persistence in Africans?

Page 10: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Do C-14010, G-13915 and G-13907 SNPs affect expression in vitro?

Page 11: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

How old are these haplotypes?

Page 12: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Are there evidences of Natural Selection?

Page 13: LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations

Are there evidences of Natural Selection?

Yes! Convergent evolution of LP-associated variants

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