lichen planus and related conditions by: dr. faraedon kaftan school of medicine sulaimani university...
TRANSCRIPT
![Page 1: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/1.jpg)
Lichen Planus and
related conditionsBy: Dr. Faraedon Kaftan
School of MedicineSulaimani University
L 42012 - 2013
![Page 2: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/2.jpg)
1. Lichen planus: حزازمسطح
2. Follicular LP (L planopilaris)3. LP Pigmetosus/actinicus4. Erythema dyschromicum perstans5. Idiopathic eruptive macular pigmentation6. Keratosis lichenoides chronic7. Lichen nitidus8. L striatus9. Lichen sclerosus (L S et atrophicus)
![Page 3: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/3.jpg)
1. Lichen planus is a chronic mucocutaneous disease that affects
the skin, tongue, and oral mucosa. The lesions are severely pruritic papules
or rashes. The name refers to the dry and undulating,
"lichen-like" appearance of affected skin. The underlying pathology is currently unknown.
![Page 4: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/4.jpg)
Classification: LP may be divided into the following types:
:Configuration (ترتيب) Annular or Linear LP
Morphology of lesion: Hypertrophic, Atrophic, Vesiculobullous Ulcerative Follicular Actinic Lichen planus pigmentosus
Site of involvement: Palmoplantar, Mucosal, nails, scalp ( leading to cicatricial alopecia) and Inverse LP Special forms: Drug-induced, Lupus erythematosus-LP
overlap syndrome, LP pemphigoides, Keratosis lichenoides chronica, Lichenoid reaction of graft-versus-hos disease, Lichenoid keratosis, Lichenoid dermatitis
![Page 5: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/5.jpg)
Signs and symptomsof lichen planus "6 Ps": well-defined Pruritic, Planar, Purple
(violaceous), Polygonal Papules and Plaques. Commonly affected sites are near the wrist and the
ankle. The rash tends to heal with prominent blue-black or
brownish discoloration that persists for a long time. Oral lesions tend to last far longer than cutaneous lichen
planus lesions.Can resemble Atopic dermatitis and Psoriasis.
![Page 6: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/6.jpg)
3 forms of Oral lichen planus (OLP):
1. The reticular form is the most common presentation and manifests as white lacy (شريتيى) streaks on the mucosa, bilateral and are asymptomatic.
2. The bullous form 3. The erosive forms (Atrophic LP & Ulcerative LP)
![Page 7: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/7.jpg)
LP may also affect the genital mucosa – vulvovaginal-gingival lichen planus.
Clinical experience suggests that Lichen planus of the skin alone is easier to treat as compared to one which is associated with oral and genital lesions.
![Page 8: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/8.jpg)
Nail & hair loss is irreversible. Nail changes are:Nail involvement in 10% of individuals with
disseminated LPNail involvement may be the only manifestation of
LPThin nail plate and longitudinal ridgingLunula is more elevated than the more distal
portion
![Page 9: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/9.jpg)
Cause of LP:LP is not contagious and does not involve any known pathogenMay be associated with:Drug for high blood pressure, heart disease and arthritiscomplication of chronic hepatitis C virus infectioncan be a sign of chronic graft-versus-host disease of the
skinThe microscopic appearance of LP is pathognomonic for
the conditionHyperparakeratosis with thickening of the granular cell layerDevelopment of a "saw-tooth" appearance of the rete pegsDegeneration of the basal cell layer with Civatte or colloid
body formation. Infiltration of lymphocytic inflammatory cells into the
subepithelial layer of connective tissue
![Page 10: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/10.jpg)
TreatmentLichen planus may last few months – 18 msLP can flare up years after it is considered cured.Medicines used to treat lichen planus include:Systemic antipruriticsOral and topical steroidsOral retinoids immunosuppressant medicationsChloroquine TacrolimusDapsoneNon-drug treatments: UVB Narrow Band Phototherapy, Aloe vera and Purslane
![Page 11: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/11.jpg)
2. Follicular LP (L planopilaris)is a follicular form of hair loss which causes
cicatricial scarring, is considered to have an autoimmune cause.
![Page 12: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/12.jpg)
3. LP Pigmetosus/actinicus (LP tropicus)- is more common in Middle Eastern countries in spring
and summer, where sunlight appears to have a precipitating effect
- Exposed parts: the face, dorsal hands and arms, and nape of the neck
- Papules that are hyperpigmented and violaceous-brown in color with a thready, rolled edge showing well-defined borders
![Page 13: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/13.jpg)
4. Erythema dyschromicum perstansalways before 40 years old, Symmetrical and generalized skin lesions
![Page 14: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/14.jpg)
5. Idiopathic eruptive macular pigmentation
- Occurs in young persons, with an average age of 11
- Asymptomatic widespread brown to gray macules of up to several cms in diameter on the neck, trunk, and proximal extremities
![Page 15: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/15.jpg)
6. Keratosis lichenoides chronicis a rare dermatosis characterized by
violaceous papular and nodular lesionslinear or reticulate pattern on the dorsal hands and
feet, extremities, and buttock
![Page 16: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/16.jpg)
7. Lichen nitidus- is a chronic inflammatory disease of
unknown etiology
- 1–2 mm, discrete and uniform, shiny, flat-topped, pale flesh-colored or reddish-brown papules
- usually affects children and young adults- is painless and usually nonpruritic- Linear arrangements of these papules is common
(referred to as a Koebner Phenomenon), especially on the forearms
![Page 17: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/17.jpg)
8. Lichen striatus is a common and benign self-limited childhood dermatosis
that is easily diagnosed from its classic appearance. Onset is between the ages of (3 and 10 years), and it is rare
in young infants, adolescents, and adults. Pink, flesh-colored, or slightly hypopigmented flat-topped
papules that evolve in a linear array following lines of Blaschko
The linear course of the papules may eventually traverse the major part of an extremity.
![Page 18: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/18.jpg)
lines of Blaschko
![Page 19: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/19.jpg)
The area of involvement is often noted to become wider as it advances and may even include the nails.
Spontaneously regress within (3-12 months), no treatment is needed.
Rx: Immunomodulators (Tacrolimus and pimecrolimus) on the face and extremities.
![Page 20: Lichen Planus and related conditions By: Dr. Faraedon Kaftan School of Medicine Sulaimani University L 4 2012 - 2013](https://reader030.vdocuments.net/reader030/viewer/2022032804/56649e585503460f94b50a13/html5/thumbnails/20.jpg)
9. Lichen sclerosus (L S et atrophicus) (LSA):
Unknown cause Women are more commonly affected than men (10
to 1 ratio), Most commonly occurs on the vulva and around
the anus with ivory-white elevations that may be flat and glistening.
marked itching or without any symptoms.