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Encyclopedia of Molecular Mechanisms of Disease
FLORIAN LANG (Ed.)
Encyclopedia of MolecularMechanisms of Disease
With 646 Figures* and 213 Tables
*For color figures please see our Electronic Reference on www.springerlink.com
Editor:Prof. Dr. med. Florian LangInstitute of PhysiologyUniversity of TuebingenTuebingen, [email protected]
A C.I.P. Catalog record for this book is available from the Library of Congress
ISBN: 978-3-540-67136-7This publication is available also as:Electronic publication under ISBN 978-3-540-29676-8 andPrint and electronic bundle under ISBN 978-3-540-33445-3Library of Congress Control Number 2008930847
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights oftranslation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks.Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, inits current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under theGerman Copyright Law.
© Springer-Verlag GmbH Berlin Heidelberg 2009
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such namesare exempt from the relevant protective laws and regulations and therefore free for general use.
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Preface
Pathophysiology describes mechanisms of disease and is thus at the interface between basic research and clinicalmedicine. The aim of this comprehensive encyclopedia is to supply the reader with concise information onmolecular pathophysiology, a research area of breathtaking gain of knowledge. We trust that the book shall be avaluable companion for both basic scientists exploring the clinical hallmarks of the diseases they are interested in,and clinicians searching for insight into the molecular pathophysiology of their patients. The entries are structuredto allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by keyreferences.
The editor is indebted to the section editors for their superb support in selecting the appropriate entries and choosingthe leading experts in the respective areas of research. The editor further wishes to express his appreciation to themany brilliant authors who delivered outstanding state-of-the-art descriptions of pathophysiological mechanisms.
In addition, the book would not have come to reality without the dedicated, professional and creative support ofmy secretaries Tanya Loch and Jasmin Bühringer and by several staff members of the Springer Publishinghouse including Dr. Michaela Bilic, Jana Simniok, Hiltrud Wilbertz, Dr. Rolf Lange, and Dr. Thomas Mager.
FLORIAN LANG, March 2008
Editor-in-Chief
Prof. Dr. med. Florian LangInstitute of PhysiologyUniversity of TuebingenTuebingen, [email protected]
Field Editors
CHRISTIAN BAUER
Université Claude Bernard,Lyon, [email protected](Section: Blood Disorders)
ALESSANDRA BAUMER
Institute of Medical Genetics,University of Zurich,Zurich, [email protected](Section: Chromosomal Disorder)
MICHAEL BECKER
The University of Chicago,Chicago, IL, [email protected](Section: Purine Metabolism)
HANS-KONRAD BIESALSKI
Department of Biological Chemistry and Nutrition,University Hohenheim,Stuttgart, [email protected](Section: Vitamins & Trace Elements)
STEFAN BORNSTEIN
Medical Clinic III,University Hospital Dresden,Dresden, [email protected](Section: Endocrinology)
KENNETH L. BRIGHAM
Department of MedicineEmory University School of Medicine,Atlanta, GA, [email protected](Section: Respiratory Disease)
WOLFGANG DIETMAIER
Institute of Pathology,University of Regensburg,Regensburg, [email protected](Section: Tumor Biology)
TILMAN B. DRÜKE
Hopital Necker,Paris, [email protected](Section: Bone and Mineral Disease)
GERD HASENFUßDepartment of Cardiology andPneumology,University of Goettingen,Goettingen, [email protected](Section: Cardiovascular System)
DIETER HÄUSSINGER
Clinic for Gastroenterology, Hepatologyand Infectiology,Heinrich-Heine-University,Duesseldorf, [email protected](Sections: Gastroenterology, Hepatology)
FRIEDHELM HILDEBRANDT
University of Michigan Health System,Ann Arbor, MI, [email protected](Section: Renal and Combined Disease)
KEITH A. HRUSKA
Barnes-Jewish Hospital,Washington University School ofMedicine,St. Louis, MO, [email protected](Section: Bone and Mineral Disease)
GARY HUNNINGHAKE
School of Medicine,University of Iowa,Iowa City, IA, [email protected](Section: Respiratory Disease)
MARTIN KONRAD
Department of Pediatrics,University of Muenster,Muenster, [email protected](Section: Bone and Mineral Disease)
KARL KUNZELMANN
Department of Physiology,University of Regensburg,Regensburg, [email protected](Section: Respiratory Disease)
FLORIAN LANG
Institute of Physiology,University of Tuebingen,Tuebingen, [email protected](Conceptual Editor for Several Sections)
KARL S. LANG
Ontario Cancer Institute,University Toronto,Toronto, ON, [email protected](Section: Immunology)
UNDINE E. LANG
Department of Psychiatry and Psychotherapy,Charité University Medicine Berlin,Berlin, [email protected](Section: Psychiatry)
FRANK LEHMANN-HORN
Applied Physiology,Ulm University,Ulm, [email protected](Section: Neurology)
HOLGER LERCHE
Applied Physiology,Ulm University,Ulm, [email protected](Section: Neurology)
DEREK LEROITH
Division of Endocrinology, Diabetes and Bone Disease,Mount Sinai School of Medicine,New York, NY, [email protected](Section: Endocrinology)
THOMAS LUGER
Department of Dermatology,University Hospital of Muenster,Muenster, [email protected](Section: Skin)
REUBEN MATALON
Department of Pediatrics,University of Texas Medical Branch (UTMB),Galveston, TX, [email protected](Section: Amino Acid Metabolism)
DIETER METZE
Department of Dermatology,University Hospital of Muenster,Muenster, [email protected](Section: Skin)
LESTER PACKER
Department of Molecular Pharmacology andToxicology,School of Pharmacy,University of Southern California,Los Angeles, CA, [email protected](Section: Vitamins & Trace Elements)
MARKUS PFISTER
Department of Otolaryngology and Head andNeck Surgery,University of Tuebingen,Tuebingen, [email protected](Section: ENT)
MIKE RECHER
Clinic for Immunology, Department of InternalMedicine,University Hospital Zurich,Zurich, [email protected](Section: Immunology)
KONRAD SANDHOFF
LIMES Institute Program Unit,Membrane Biology and LipidBiochemistry Unit,University of Bonn,Bonn, [email protected](Section: Lipid Storage Diseases)
ALBERT SCHINZEL
Institute of Medical Genetics,University of Zurich,Zurich, [email protected](Section: Chromosomal Disorder)
H. ANNE SIMMONDS
Purine Research Unit,Guy's Hospital,London, [email protected](Section: Purine Metabolism)
x Field Editors
OLAF STRAUßExperimental Ophthalmology,Department of Ophthalmology,University Regensburg,Regensburg, [email protected](Section: Ophthalmology)
HUGO TEN CATE
Department of Internal Medicine and of Biochemistry,Maastricht University,Maastricht, The [email protected](Section: Blood Disorders)
KURT ULLRICH
Children's Hospital,University Clinics Eppendorf,Hamburg, [email protected](Section: Amino Acid Metabolism)
HANS-PETER ZENNER
Department of Otolaryngology and Head andNeck Surgery,University of Tuebingen,Tuebingen, [email protected](Section: ENT)
EBERHARDT ZRENNER
University Eye Hospital,Tuebingen, [email protected](Section: Ophthalmology)
Field Editors xi
List of Contributors
DIETRICH ABECK
Department of Dermatology and AllergologyTechnische Universitaet [email protected]
OLADAPO ADEWUYA
Department of PathologyUniversity of Texas Medical BranchHouston, TXUSA
GUIDO ADLER
Department of Internal Medicine IUlm [email protected]
ALI R. AFZAL
Department of Cardiological SciencesSt. George’s Hospital Medical [email protected]
VIMLA S. AGGARWAL
Department of Molecular GeneticsAlbert Einstein College of MedicineNew York, NYUSA
PUSHPA AGRAWAL
Institute of Microbial [email protected]
WALID AHMAR
MonashHeartSouthern Health and Department of MedicineMonash UniversityMelbourne, [email protected]
MINRONG AI
Department of Genetics and Center for Human GeneticsCase School of MedicineCleveland, [email protected]
NAIDU K. AKHILENDER
Department of Biochemistry and NutritionCentral Food Technological Research [email protected]
SUHAIL ALAM
Department of Environmental and Biomolecular SystemsOGI School of Science and EngineeringOregon Health and Science UniversityBeaverton, ORUSA
JESSY J. ALEXANDER
Section of NephrologyUniversity of ChicagoChicago, [email protected]
GIDON ALMOGY
Department of SurgeryHadassah University HospitalJerusalemIsrael
NURSEL ALPAN
Department of Cardiology, Ministry of HealthAnkara Diskapi Children’s Diseases Training and ResearchHospitalAnkaraTurkey
CRISTINA AMAT DI SAN FILIPPO
Medical Genetics/PediatricsUniversity of UtahSalt Lake City, [email protected]
RICHARD F. AMBINDER
Viral Oncology Program, Sidney Kimmel Cancer CenterJohns Hopkins UniversityBaltimore, [email protected]
CHRISTINA M. AMBROS-RUDOLPH
Department of DermatologyMedical University of [email protected]
DETLEV AMEIS
Department of Internal Medicine IIEvangelic Hospital [email protected]
KATHERINE K. ANAGNOSTOPOULOU
First Cardiology DepartmentOnassis Cardiac Surgery CenterAthensGreece
YUMIKO ANDO
Department of Diagnostic and Interventional RadiologyOita University Faculty of MedicineOitaJapan
VICENTE ANDRÉS
Vascular Biology UnitInstituto de Biomedicina de Valencia (IBV-CSIC)Spanish Council for Scientific [email protected]
BRAGE STORSTEIN ANDRESEN
Institute of Human Genetics and Research Unit for MolecularMedicineAarhus [email protected]
CORRADO ANGELINI
Department of NeurosciencesUniversity of [email protected]
CHARLES ANTZELEVITCH
Experimental CardiologyMasonic Medical Research LaboratoryUtica, [email protected]
AMELIA ARÁNEGA
Department of Experimental BiologyUniversity of [email protected]
SAMUEL J. ARBES
Laboratory of Respiratory Biology, NIH/NIEHSResearch Triangle Park, NCUSA
MONICA ARENAS
Purine Research LaboratoryGuy’s [email protected]
ANDRES AREND
Department of AnatomyUniversity of [email protected]
JOSEP M. ARGILÉS
Departament de Bioquímica i BiologiaMolecular Universitat de [email protected]
GEMA ARICETA
Division of Pediatric Kidney DiseasesHospital de CrucesVizcayaSpain
JELENA S. ARNOLD
Department of Molecular GeneticsAlbert Einstein College of MedicineNew York, NYUSA
FRIEDRICH ASMUS
Department of Neurodegnerative DiseasesHertie-Institute for Clinical Brain ResearchCenter of [email protected]
JOHN R. ASPLIN
Department of Medicine, Section NephrologyUniversity of ChicagoChicago, [email protected]
MOHAMED G. ATTA
Department of NephrologyJohns Hopkins University School of MedicineBaltimore, [email protected]
MASSIMO ATTANASIO
Department of PediatricsUniversity of MichiganAnn Arbor, [email protected]
MARINA AUNAPUU
Department of AnatomyUniversity of [email protected]
INGO B. AUTENRIETH
Institute for Medical Microbiology and HygieneUniversity of [email protected]
xiv List of Contributors
MAURIZIO AVERNA
Department of Clinical Medicine and Emerging DiseasesUniversity of PalermoPalermoItaly
MA. ROSA AVILA
Comprehensive Epilepsy Program, Epilepsy Genetics/Genomics Laboratories and Epilepsy Center of ExcellenceUCLA School of Medicine and VA GLAHSLos Angeles, CAUSA
JUAN CARLOS AYUS
Renal Consultants of HoustonHouston, TXUSA
GOHAR AZHAR
University of Arkansas for Medical SciencesGRECC and CAVHSLittle Rock, [email protected]
SHAH AZMOON
Division of CardiologyVeterans Affairs Greater Los Angeles Healthcare System andThe David Geffen School of Medicine at UCLALos Angeles, CAUSA
FERNANDO AZPIROZ
Digestive System Research UnitHospital General Vall d’[email protected]
ANGELO AZZI
Vascular Biology Laboratory JM USDA – HNRCATufts University BostonBoston, [email protected]
ULRIKE BACHER
Department of Stem Cell TransplantationUniversity of [email protected]
RAFFAELE BADOLATO
Clinica PediatricaUniversita’ di [email protected]
JONATHAN BAETS
Neurogenetics GroupVIB Department of Molecular GeneticsUniversity of [email protected]
MATHIAS BÄHR
Department of NeurologyNational Reference Center for TSE SurveillanceGeorg-August [email protected]
MEI BAI
Division of Endocrinology, Diabetes and HypertensionBrigham and Women’s HospitalBoston, [email protected]
DAMIAN MILES BAILEY
Neurovascular Research LaboratoryFaculty of Health, Science and SportUniversity of [email protected]
ALFONSO BALDI
Department of Biochemistry, Section of PathologySecond University of [email protected]
NICOLA BALDINI
Laboratorio di Fisiopatologia degli Impianti OrtopediciIstituto Ortopedico RizzoliBolognaItaly
WENDY BALEMANS
Department of Medical GeneticsUniversity and University Hospital of [email protected]
MANFRED BALLMANN
Department of Pediatric Pneumology and NeonatologyMedical School [email protected]
MANISHA BALWANI
Department of Genetics and Genomic SciencesMount Sinai School of Medicine of New York UniversityNew York, NYUSA
List of Contributors xv
ANNEMIEKE M. BAMS-MENGERINK
Department of PediatricsEmma Children’s HospitalAcademic Medical CenterAmsterdamThe [email protected]
IRIS BARTELS
Institute of Human GeneticsUniversity [email protected]
ANDREAS BARTHEL
Endokrinologikum RuhrBochumGermany
DEBORAH BARTHOLDI
Institute of Medical GeneticsUniversity of [email protected]
OLIVER BARTSCH
Institute of Clinical GeneticsDresden University of [email protected]
PETER BÄRTSCH
Department of Internal Medicine VIIDivision of Sports MedicineMedical University [email protected]
MURAT BAS
HNOTechnische UniversitaetMunichGermany
DANIEL BATLLE
Division of Nephrology and HypertensionFeinberg School of MedicineNorthwestern UniversityChicago, [email protected]
AGATINO BATTAGLIA
The Stella Maris ClinicalResearch Institute for Child and Adolescent Neurologyand [email protected]
ALESSANDRA BAUMER
Institute of Medical GeneticsUniversity of [email protected]
JEROEN J. BAX
Department of CardiologyLeiden University Medical CenterLeidenThe [email protected]
JOHANNES BAYER
Department of DermatologyUniversity of MuensterMuensterGermany
NIKOLAOS E. BECHRAKIS
Department of OphthalmologyMedical University of [email protected]
MICHAEL BECK
Children’s HospitalUniversity of [email protected]
HEINZ BECK
Laboratory of Experimental Epileptologyand Cognition ResearchDepartment of EpileptologyLife and Brain [email protected]
MICHAEL A. BECKER
Department of MedicineUniversity of ChicagoPritzker School of MedicineChicago, [email protected]
ALAN H. BEGGS
Genetics Division and Program in GenomicsChildren’s HospitalHarvard Medical SchoolBoston, [email protected]
xvi List of Contributors
FRANK BEIER
CIHR Group in Skeletal Development and RemodelingDepartment of Physiology and PharmacologyUniversity of Western OntarioLondon, [email protected]
STEFAN BEISSERT
Department of DermatologyUniversity of [email protected]
RAFFI BEKEREDJIAN
Department of CardiologyUniversity of HeidelbergHeidelbergGermanyraffi.bekeredjian@med.uni-heidelberg.de
HENDRICA BELGE
Division of NephrologyUCL Medical SchoolBrusselsBelgium
JOHN W. BELMONT
Department of Molecular and Human GeneticsBaylor College of MedicineHouston, [email protected]
JOHN A. BELPERIO
Department of Internal MedicineThe David Geffen School of Medicine at UCLALos Angeles, CAUSA
MICHAEL BENATAR
Department of NeurologyEmory University School of MedicineAtlanta, [email protected]
HERZL BEN-HUR
Laboratory of Experimental [email protected]
ANGELA BENTIVEGNA
Division of Medical GeneticsSan Paolo School of MedicineUniversity of MilanMilanItaly
ROSSANA BERARDI
Clinica di Oncologia MedicaUniversità Politecnica delle MarcheOspedali Riuniti Umberto I – GM Lancisi – G Salesi diAnconaAnconaItaly
JO H. M. BERDEN
Nephrology Research LaboratoryNijmegen Centre for Molecular Life SciencesDivision of NephrologyRadboud University Nijmegen Medical CentreNijmegenThe [email protected]
WOLFGANG BERGER
Division of Medical Molecular Genetics and GeneDiagnosticsInstitute of Medical GeneticsUniversity of [email protected]
MARGHERITA BERGOMI
Department of Public Health SciencesUniversity of Modena and Reggio [email protected]
SAMUEL F. BERKOVIC
Epilepsy Research CentreDepartment of MedicineUniversity of MelbourneWest Heidelberg, VICAustralia
MAURO BERNARDI
Dipartimento di Medicina Interna, Cardioangiologia,EpatologiaAlma Mater Studiorum Università di [email protected]
MARK BERNEBURG
Department of DermatologyEberhard Karls [email protected]
FELIX BEUSCHLEIN
Medical ClinicLudwig-Maximilians-UniversityMunichGermanyfelix.beuschlein@med.uni-muenchen.de
List of Contributors xvii
RUDI BEYAERT
Department of Molecular BiologyGhent University, [email protected]
KATRIN BEYER
Department of PathologyHospital Universitari Germans Trias i [email protected]
FRIEDHELM BEYERSDORF
Department of Cardiovascular SurgeryUniversity Medical Center FreiburgFreiburgGermany
ROBERT J. BEYNON
Department of Veterinary Preclinical SciencesUniversity of [email protected]
KONRAD BEYREUTHER
ZMBHUniversity of [email protected]
MICHALA BEZDEKOVA
Department of Pathology andLaboratory of Molecular PathologyPalacky UniversityOlomoucCzech Republic
RAVI BHARGAVA
Department of RadiologyStollery Children’s HospitalUniversity of AlbertaEdmonton, [email protected]
JAVEED I. BHAT
Department of PediatricsShere-Kashmir Institute of Medical Sciences (SKIMS)Srinagar, KashmirIndia
MUSHTAQ A. BHAT
Department of PediatricsShere-Kashmir Institute of Medical Sciences (SKIMS)Srinagar, [email protected]
KAILASH P. BHATIA
Sobell Department of Motor Neuroscienceand Movement DisordersInstitute of [email protected]
CHRISTIAN G. BIEN
Department of EpileptologyUniversity of [email protected]
MARTINA BIENOVA
Department of DermatovenerologyPalacky University and University HospitalOlomoucCzech [email protected]
HANS K. BIESALSKI
Department of Biological Chemistry and NutritionUniversity [email protected]
BEVERLY M. K. BILLER
Neuroendocrine UnitMassachusetts General HospitalBoston, [email protected]
MARCELO GUSTAVO BINKER
CBRHC InstituteBuenos AiresArgentina
RIFAT BIRCAN
Department of Medical BiologyMarmara University Medical SchoolIstanbulTurkey
MICHELE BISCEGLIA
Department of PathologyIRCCS “Casa Sollievo della Sofferenza” HospitalSan Giovanni [email protected]
STEPHAN C. BISCHOFF
Nutritional Medicine and PreventionUniversity of [email protected]
xviii List of Contributors
ROLAND BITSCH
Institute for NutritionFriedrich-Schiller-University [email protected]
JERRY G. BLAIVAS
Department of UrologySuny Downstate Medical SchoolNew York, [email protected]
NENAD BLAU
Division of Clinical Chemistry and BiochemistryUniversity Children’s [email protected]
ANTHONY J. BLEYER
Section of NephrologyWake Forest University School of MedicineWinston-Salem, [email protected]
NIKOLAUS BLIN
Department of Molecular PathologyUniversity Hospital of TuebingenTuebingenGermany
GERARD C. BLOBE
Medicine, Pharmacology and Cancer BiologyDuke UniversityDurham, [email protected]
ANNA BLONSKA
Department of Molecular GeneticsAlbert Einstein College of MedicineNew York, NYUSA
HUBERT E. BLUM
Department of Medicine IIUniversity [email protected]
OLAF A. BODAMER
Biochemical Genetics and National Neonatal ScreeningLaboratories Department of General PediatricsUniversity Children’s Hospital [email protected]
JOHANNES G. BODE
Department of Gastroenterology, Hepatology andInfectiologyUniversity-HospitalHeinrich-Heine University DuesseldorfDuesseldorfGermanyJohannes.Bode@med.uni-duesseldorf.de
CORNELIUS F. BOERKOEL
Centre for Molecular Medicine and Therapeutics, Child andFamily Research InstituteDepartment of Medical GeneticsUniversity of British ColumbiaVancouver, [email protected]
MARKUS BÖHM
Department of DermatologyUniversity Hospital of [email protected]
REGINA BÖKENKAMP
Department of Anatomy and EmbryologyLeiden University Medical CenterLeidenThe [email protected]
JACKY BONAVENTURE
Institut CurieCentre Universitaire Paris [email protected]
BRIGITTA BONDY
Section Psychiatric Genetics and NeurochemistryPsychiatric Hospital of Munich [email protected]
HERBERT L. BONKOVSKY
Research Cannon Research CenterCarolinas Medical CenterCharlotte, [email protected]
GISÈLE BONNE
Institut de Myologie UPMCGroupe Hospitalier Pitié-Salpêtriè[email protected]
List of Contributors xix
KEVIN M. BONNEY
Departments of Pathology and Microbiology-ImmunologyNorthwestern University Feinberg School of MedicineChicago, [email protected]
CHRISTOPHER J. BOOS
Hemostasis, Thrombosis and Vascular Biology UnitUniversity Department of MedicineCity HospitalBirminghamUK
FRANCESCO BORGIA
Institute of DermatologyPoliclinico UniversitarioMessinaItaly
JULIAN ILCHEFF BORISSOFF
Laboratory for Clinical Thrombosis and HemostasisDepartment of Internal MedicineUniversity of MaastrichtMaastrichtThe Netherlands
STEFAN R. BORNSTEIN
Medical Clinic IIIUniversity Hospital [email protected]
CARL BORREBAECK
Department of ImmunotechnologyLund [email protected]
NIELS BORREGAARD
Department of HematologyRigshospitalet University of [email protected]
DORIN-BOGDAN BORZA
Division of NephrologyVanderbilt University School of MedicineNashville, [email protected]
MARK BOTHWELL
Department of Physiology and BiophysicsUniversity of WashingtonSeattle, [email protected]
HENRI BOUNAMEAUX
Angiology and HemostasisUniversity Hospitals of [email protected]
THOMAS BOURGERON
Pasteur InstituteUniversity Denis [email protected]
PATRICIA T. BOZZA
Immunopharmacology LaboratoryInstituto Oswaldo CruzFundação Oswaldo CruzRio de [email protected]
MARIA LUISA BRANDI
Regional Center for Hereditary Endocrine TumoursDepartment of Internal MedicineUniversity of [email protected]
THOMAS BRANDT
Department of NeurologyLudwig-Maximilians-UniversityKlinikum Groß[email protected]
MARKUS BRAUN-FALCO
Department of DermatologyUniversity of [email protected]
ALANNA F. BREE
Texas Children’s HospitalHouston, [email protected]
RANDOLF BREHLER
Department of DermatologyUniversity Hospital of [email protected]
MICHAEL BRIGGS
Wellcome Trust Centre for Cell Matrix ResearchUniversity of [email protected]
xx List of Contributors
PEDRO BRITES
Laboratory of Genetic Metabolic DisordersAcademic Medical CenterUniversity of AmsterdamAmsterdamThe [email protected]
KNUT BROCKMANN
Department of Pediatrics and Pediatric NeurologyUniversity of [email protected]
STEFAN BRÖER
School of Biochemistry and Molecular BiologyAustralian National UniversityCanberra, [email protected]
EIRINI I. BROKALAKI
Department of Dermatology, Allergology and VenerologyUniversity of [email protected]
DAVID W. BROWN
Department of CardiologyChildren’s HospitalBoston, [email protected]
EDWARD M. BROWN
Division of Endocrinology, Diabetes and HypertensionBrigham and Women’s HospitalBoston, [email protected]
LEENA BRUCKNER-TUDERMAN
Department of DermatologyUniversity Medical [email protected]
ANNA BRUNN
Department of NeuropathologyUniversity of CologneCologneGermany
MARTINA BRUNNER
Department of Dermatology, Venerology, Allergology andImmunologyDessau Medical [email protected]
TOMAS BRYCHTA
SPEA Olomouc, s.r.o.OlomoucCzech [email protected]
SVETLANA BRYCHTOVA
Department of Pathology and Laboratory of MolecularPathologyPalacky UniversityOlomoucCzech [email protected]
JAN BUBENÍK
Department of Tumour ImmunologyInstitute of Molecular GeneticsAcademy of Sciences of the Czech RepublicPragueCzech [email protected]
THORSTEN BUCH
University Clinic [email protected]
KAREN BUCKINGHAM
Department of Obstetrics and GynaecologyUniversity of AucklandAuckland, AUKNew [email protected]
MARK G. BUCKLEY
Infection, Inflammation and RepairUniversity of SouthamptonSchool of MedicineSouthamptonUK
DENNIS E. BULMAN
Ottawa Health Research InstituteOttawa, [email protected]
CARSTEN BÜNING
Department of Gastroenterology,Hepatology and EndocrinologyCharité University [email protected]
GÜNTER BURG
Department of DermatologyUniversity Hospital [email protected]
List of Contributors xxi
ANNIKA BUROW
Swiss Cardiovascular Center BernUniversity HospitalBernSwitzerland
HARAN BURRI
Cardiovascular DepartmentHôpital de La TourMeyrinSwitzerland
ANDREW K. BURROUGHS
Department of Liver Transplantationand Hepatobiliary SurgeryRoyal Free HospitalHampstead, [email protected]
BARBARA BUSERT
Institute of Human GeneticsBonnGermany
LUCA BUSETTO
Department of Medical and Surgical SciencesUniversity of [email protected]
KATE BUSHBY
Institute of Human GeneticsNewcastle UniversityInternational Centre for LifeNewcastle upon [email protected]
SÍLVIA BUSQUETS
Departament de Bioquímica i Biologia MolecularUniversitat de [email protected]
JANINE BÜTTNER
Department of Gastroenterology, Hepatology andEndocrinologyCharité University [email protected]
KENNETH CALAMIA
Department of RheumatologyMayo ClinicJacksonville, [email protected]
CECILIA CAMACHO-HÜBNER
Pediatric Endocrinology SectionDepartment of EndocrinologySt. Bartholomew’s [email protected]
MARYANN CAMERON
Center for Mineral Metabolism and Clinical ResearchUniversity of Texas Southwestern Medical CenterDallas, [email protected]
MICHAEL CANTZ
Institute of PathologyUniversity of [email protected]
GIOVAMBATTISTA CAPASSO
Department of MedicineSecond University of [email protected]
JONATHAN R. CARAPETIS
Menzies School of Health ResearchCharles Darwin UniversityDarwin, [email protected]
MARTIN C. CAREY
Gastroenterology Division, Harvard Medical SchoolBrigham and Women’s HospitalBoston, [email protected]
MICHELLE A. CAREY
Laboratory of Respiratory BiologyNIH/NIEHSResearch Triangle Park, NCUSA
NATALIA CASAMITJANA
Servei d’ImmunologiaHospital de Sant PauBarcelonaSpain
MARCIA SPINELLI CASANOVA
Department of Oral DiagnosisUNICAMP, Piracicaba Dental SchoolSão [email protected]
xxii List of Contributors
STEFANO CASCINU
Clinica di Oncologia MedicaUniversità Politecnica delle MarcheOspedali Riuniti Umberto I – GM Lancisi – G Salesi [email protected]
MARCO CASTORI
Medical Genetics, Experimental Medicine DepartmentUniversity La SapienzaS. Camillo-Forlanini [email protected]
PATRIZIO CATUREGLI
Department for Pathology and ImmunologyJohns Hopkins UniversityBaltimore, MDUSA
ANDREA CAVANI
Laboratory of Immunology and AllergologyIstituto Dermopatico dell’[email protected]
FERNANDO CENDES
Department of NeurologyUniversity of Campinas – UNICAMPCampinas, [email protected]
LORENZO CERRONI
Department of DermatologyMedical University of [email protected]
ELIZA F. CHAKRAVARTY
Division of Immunology and RheumatologyStanford University School of MedicinePalo Alto, [email protected]
STEPHEN CHALLACOMBE
Department of Oral MedicineKings College London Dental InstituteLondonUK
LARRY CHAMLEY
Fertility PlusGreenlane Clinical CentreAuckland, AUKNew [email protected]
ANTHONY CHANG
Section of NephrologyUniversity of ChicagoChicago, ILUSA
PETER CHARBEL ISSADepartment of OphthalmologyUniversity of BonnBonnGermany
SAURABH CHATTERJEE
Immunology and Hyperthermia SectionRadiation Biology and Health Sciences DivisionBhabha Atomic Research CentreMumbaiIndia
KAZUAKI CHAYAMA
Department of Medicine and Molecular ScienceGraduate School of Biomedical SciencesHiroshima [email protected]
ROY F. CHEMALY
Department of Infectious Diseases, Infection Control andEmployee HealthThe University of Texas M. D. Anderson Cancer CenterHouston, [email protected]
ZHUANG CHEN
Department of Pediatrics,Biochemistry and Molecular BiologyIndiana University School of MedicineHerman B Wells Center for Pediatric ResearchIndianapolis, INUSA
S. R. WAYNE CHEN
Libin Cardiovascular Institute of AlbertaUniversity of CalgaryCalgary, [email protected]
ALFREDO CHETTA
Department of Clinical Sciences, Respiratory Disease SectionUniversity of [email protected]
KAVITHA M. CHINNAIYAN
Division of Cardiology, Department of Internal MedicineWilliam Beaumont HospitalRoyal Oak, [email protected]
List of Contributors xxiii
PERCY CHIU
Department of Obstetrics and GynecologyCollege of MedicinePennsylvania State UniversityHershey, PAUSA
PAUL CHEUNG-LUNG CHOI
Department of Anatomical and Cellular PathologyPrince of Wales HospitalChinese University of Hong KongHong Kong Special Administrative RegionPeople’s Republic of China
EVANGELOS CHOLONGITAS
Department of Liver Transplantation and HepatobiliarySurgeryRoyal Free HospitalHampstead, LondonUK
JANICE Y. CHOU
Section on Cellular Differentiation, HeritableDisorders BranchNational Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesda, [email protected]
CHIU-WING WINNIE CHU
Department of Diagnostic Radiology and Organ ImagingPrince of Wales HospitalHong Kong Special Administrative RegionPeople’s Republic of China
KIRPAL S. CHUGH
Department of NephrologyPostgraduate Institute of Medical Education and [email protected]
ROBERTO CICCONE
Genetica MedicaUniversità di PaviaPaviaItaly
ANDREA CIGNARELLA
Department of Pharmacological SciencesUniversity of [email protected]
DANIELA CILLONI
Department of Clinical and Biological SciencesUniversity of Turin, S.Luigi [email protected]
ADRIAN J. L. CLARK
Pediatric Endocrinology SectionDepartment of EndocrinologySt. Bartholomew’s HospitalLondonUK
ANTHONY J. CLEARE
Institute of PsychiatryKings College [email protected]
ANGEL COGOLLUDO
Department of PharmacologySchool of MedicineUniversity Complutense of [email protected]
DENNIS V. COKKINOS
First Cardiology DepartmentOnassis Cardiac Surgery [email protected]
NANANDA F. COL
Center for Outcomes Research and EvaluationMaine Medical CenterPortland, [email protected]
DAVID E. C. COLE
Departments of Laboratory Medicine and Pathobiology,Medicine and Pediatrics (Genetics)University of TorontoToronto, ONCanada
GIUSEPPINA COPPOLA
Unit of Rheumatology, Department of Clinical Medicine andImmunological SciencesUniversity of [email protected]
VALÉRIE CORMIER-DAIRE
Département de Génétique and INSERMUniversité Paris VHôpital Necker Enfants MaladesParisFrance
CATHERINE E. CORREIA
Division of Pediatric EndocrinologyUniversity of Florida College of MedicineGainsville, FLUSA
xxiv List of Contributors
JONATHAN CORREN
Allergy Research FoundationLos Angeles, [email protected]
LAURA IRIS COSEN-BINKER
Cátedra de Gastroenterología y Enzimología Clínica –Departamento de Bioquímica Clínica, Facultad de Farmacia yBioquímicaUniversidad de Buenos AiresBuenos [email protected]
CORNELIUS COURTS
Department of NeuropathologyUniversity of CologneCologneGermany
PATRICK COUTURE
Institute on Nutraceuticals and Functional FoodsLaval UniversityQuébec, QCCanada
JACK B. COWLAND
Department of HematologyRigshospitalet University of [email protected]
JAMES E. CROWE JR.Program in Vaccine SciencesVanderbilt UniversityNashville, [email protected]
ANNETTE CRYER
Department of OtorhinolaryngologyKlinikum Karlsruhe gGmbHKarlsruheGermany
ANTONIO L. CUESTA-MUÑOZ
Centre for the Study of Monogenic Diseases of PancreaticBeta-cellFundación IMABIS, Carlos Haya HospitalMá[email protected]
VANESSA F. CURY
Departments of Pharmacology and Oral PathologyUniversidade Federal de Minas GeraisBelo HorizonteBrazil
PEDRO R. CUTILLAS
Luwig Institute for Cancer [email protected]
BRUNO DALLAPICCOLA
Department of Experimental MedicineUniversity La Sapienza and CSS-Mendel [email protected]
ROBERT DALLA POZZA
Department of Pediatric CardiologyLudwig-Maximilians-UniversityMunichGermanyRobert.DallaPozza@med.uni-muenchen.de
HENRYK DANCYGIER
Department of Internal Medicine IIKlinikum Offenbach [email protected]
ADRIAN DANEK
Department of NeurologyLudwig-Maximilians-University [email protected]
RUTH DANZEISEN
Department of NeurologyUniversity of [email protected]
SUKRAN DARCAN
Department of Pediatric Endocrinology and MetabolismFaculty of MedicineEge UniversityBornova İ[email protected]
NIKLAS DARIN
Department of PediatricsSahlgrenska University HospitalGö[email protected]
WALTER DÄUBENER
Institute of Medical Microbiology and Hospital HygieneUniversity ClinicHeinrich-Heine-UniversityDuesseldorfGermanyWalter.Daeubener@uni-duesseldorf.de
List of Contributors xxv
SANDEEP S. DAVE
Department of Medicine, Oncology DivisionInstitute for Genome Sciences and PolicyDuke UniversityDurham, [email protected]
GLORIA L. DAVID
Laboratory of Respiratory BiologyNIH/NIEHSResearch Triangle Park, NCUSA
BATYA B. DAVIDOVICI
The Dermatology UnitKaplan Medical CenterRechovotIsrael
H. DELE DAVIES
Department of PediatricsAlberta Children’s HospitalUniversity of CalgaryCalgary, ABCanada
TERRY F. DAVIES
Division of EndocrinologyMount Sinai School of MedicineNew York, [email protected]
MANNING R. DAVIS
Department of Physiology and BiophysicsUniversity of Mississippi Medical CenterJackson, [email protected]
PETER DE JONGHE
Neurogenetics GroupVIB Department of Molecular GeneticsUniversity of [email protected]
OSCAR DE LA CALLE-MARTIN
Servei d’ImmunologiaHospital de Sant [email protected]
KLAUS-MICHAEL DEBATIN
Division of Pediatric Endocrinology and DiabetesUniversity of UlmUlmGermany
HANNA DEBIEC
University Pierre et Marie [email protected]
MARTINA DECKERT
Department of NeuropathologyUniversity of [email protected]
CHARUNGTHAI DEJTHEVAPORN
Centre for Neuromuscular Disease and Department ofMolecular NeuroscienceInstitute of NeurologyUniversity College LondonLondonUK
ETIENNE DELACRÉTAZ
Swiss Cardiovascular Center BernUniversity [email protected]
ANTONIO V. DELGADO-ESCUETA
Comprehensive Epilepsy Program, Epilepsy Genetics/Genomics Laboratories and Epilepsy Center of ExcellenceUCLA School of Medicine and VA GLAHSLos Angeles, [email protected]
LUIZ DE MARCO
Departments of Pharmacology and Oral PathologyUniversidade Federal de Minas GeraisBelo [email protected]
S. DE MARIE
Department of Medical Microbiology and Infectious DiseasesErasmus University Medical CentreRotterdamThe Netherlands
JONAS DENECKE
Department of PediatricsUniversity of [email protected]
LEE A. DENSON
Division of Gastroenterology, Hepatology, and NutritionCincinnati Children’s Hospital Medical CenterCincinnati, [email protected]
xxvi List of Contributors
GORDON DENT
Institute of Science and Technology in MedicineKeele UniversityKeele, [email protected]
FLAVIA DE PAULA
Human Genome Research CenterDepartment of Genetics and Evolutionary BiologyInstitute of BiosciencesUniversity of São PauloSão PauloBrazil
CHRISTOPHE DEPRE
Cardiovascular Research InstituteDepartment of Cell Biology and Molecular MedicineUMDNJNewark, [email protected]
MARCO C. DERUITER
Department of Anatomy and EmbryologyLeiden University Medical CenterLeidenThe [email protected]
ELOISA DE SÁ MOREIRA
Human Genome Research CenterDepartment of Genetics and Evolutionary BiologyInstitute of BiosciencesUniversity of São PauloSão [email protected]
MARCUS DESCHAUER
Department of NeurologyUniversity of Halle-WittenbergHalle/[email protected]
ROBERT J. DESNICK
Department of Genetics and Genomic SciencesMount Sinai School of Medicine of New York UniversityNew York, [email protected]
DARRYL C. DE VIVO
Colleen Giblin Laboratories for Pediatric Neurology ResearchDepartment of NeurologyColumbia UniversityNew York, [email protected]
OLIVIER DEVUYST
Division of NephrologyUCL Medical [email protected]
JEAN-CHARLES DEYBACH
Centre Français des PorphyriesINSERMHôpital Louis [email protected]
ROEL DE WEGER
Department PathologyMolecular and Immuno-PathologyUniversity Medical Center UtrechtUtrechtThe [email protected]
NARANJAN S. DHALLA
St. Boniface General Hospital Research CentreUniversity of ManitobaWinnipeg, [email protected]
ALESSIA DIANA
Dipartimento Clinico VeterinarioUniversità degli Studi di [email protected]
MARTIN DICHGANS
Department of NeurologyLudwig-Maximilians-University [email protected]
ARNE W. J. H. DIELIS
Laboratory for Clinical Thrombosis and HemostasisDepartments of Internal Medicine and BiochemistryMaastricht UniversityMaastrichtThe Netherlands
THOMAS DIERKS
Department of BiochemistryUniversity of [email protected]
WOLFGANG DIETMAIER
Institute of PathologyUniversity of RegensburgRegensburgGermanywolfgang.dietmaier@klinik.uni-regensburg.de
List of Contributors xxvii
M.CRISTINA DIGILIO
Medical GeneticsBambino Gesù [email protected]
GERHARD-PAUL DILLER
Adult Congenital Heart Centre and Centre for PulmonaryHypertension, Royal Brompton Hospital and the NationalHeart and Lung InstituteImperial [email protected]
HANER DIRESKENELI
Marmara University Medical [email protected]
ANGELA DISPENZIERI
Division of Hematology and Internal MedicineMayo Clinic and Mayo FoundationRochester, [email protected]
KLAUS DITTMANN
Division of Radiobiology & Molecular EnvironmentalResearchDepartment of Radiation OncologyEberhard-Karls UniversityTuebingenGermany
MARIA TERESA DIVIZIA
Laboratory of Molecular GeneticsG. Gaslini InstituteDepartment of PediatricsUniversity of GenovaGenovaItaly
MATTHEW B. DOBBS
Department of Orthopedic SurgeryWashington University School of MedicineSaint Louis, [email protected]
MARKUS G. DONNER
Clinic for Gastroenterology, Hepatology and InfectiologyHeinrich-Heine-UniversityDuesseldorfGermanyMarkus_Donner@yahoo.de
DAN DONOGHUE
Department of Chemistry and BiochemistryUniversity of CaliforniaSan Diego, [email protected]
OLIVIER DORSEUIL
Département de Génétique et DéveloppementInstitut CochinINSERM Université Paris [email protected]
ADEL DRISS
Winship Cancer InstituteEmory UniversityAtlanta, [email protected]
MAARTEN R. DROST
Department of Movement SciencesMaastricht UniversityMaastrichtThe [email protected]
OLIVIER DULAC
Department of Pediatric NeurologyHôpital Necker Enfants [email protected]
REINHARD DUMMER
Department of DermatologyUniversity Hospital [email protected]
MARIE-ESTELLE DUPONT
Département de Psychiatrie de l’Adolescentet du Jeune AdulteInstitut Mutualiste [email protected]
MARINUS DURAN
Department of Clinical ChemistryUniversity of AmsterdamAmsterdamThe Netherlands
REYNA M. DURON
Comprehensive Epilepsy Program, Epilepsy Genetics/Genomics Laboratories and Epilepsy Center of ExcellenceUCLA School of Medicine and VA GLAHSLos Angeles, CAUSA
PIROOZ EGHTESADY
Division of Cardiothoracic SurgeryCincinnati Children’s Hospital Medical CenterCincinnati, [email protected]
xxviii List of Contributors
JAN EHRCHEN
Department of DermatologyUniversity of MuensterMuensterGermany
GEORGE E. EHRLICH
University of Pennsylvania School of MedicinePhiladelphia, [email protected]
HENK EIJER
Orthopedic DepartmentSonnenhof [email protected]
CLAUS FERDINAND EISENBERGER
Department of General, Visceral and Pediatric SurgeryUniversity Hospital DuesseldorfHeinrich Heine [email protected]
GRAEME EISENHOFER
Clinical Neurocardiology SectionNINDS, National Institutes of HealthBethesda, [email protected]
CHRISTIAN ELGER
Department of EpileptologyUniversity of [email protected]
LEAH I. ELIZONDO
Interdepartmental Program in Cell and Molecular BiologyBaylor College of MedicineHouston, [email protected]
KAM-LUN ELLIS HON
Department of Pediatrics, Prince of Wales HospitalThe Chinese University of Hong KongHong Kong Special Administrative RegionPeople’s Republic of China
SARAH H. ELSEA
Departments of Pediatrics and Human GeneticsMedical College of Virginia CampusVirginia Commonwealth UniversityRichmond, [email protected]
HOLGER K. ELTZSCHIG
Mucosal Inflammation ProgramDepartment of Anesthesiology and Perioperative MedicineUniversity of Colorado Health Sciences CenterDenver, [email protected]
MICHAEL EMBERGER
Department of DermatologyParacelsus Private Medical UniversitySalzburgAustria
FUMIO ENDO
Department of PediatricsKumamoto University Graduate School of Medical ScienceKumamotoJapan
MAYUMI ENDO
Department of MedicineTeine Keijinkai HospitalTeine, [email protected]
ANDREW G. ENGEL
Department of NeurologyUCLA School of MedicineReed Neurologic Research CenterMayo ClinicRochester, [email protected]
JUTTA ENGEL
Institute of Physiology Department II and Tuebingen HearingResearch [email protected]
DAVID M. ENGMAN
Departments of Pathology and Microbiology-ImmunologyNorthwestern University Feinberg School of MedicineChicago, [email protected]
REGINA ENSENAUER
Dr. von Haunersches KinderspitalLudwig-Maximilians-UniversityMunichGermanyregina.ensenauer@med.uni-muenchen.de
GIULIANO ENZI
Department of Medical and Surgical SciencesUniversity of PadovaPadovaItaly
List of Contributors xxix
CHARLES J. EPSTEIN
Department of Neurology and Neurological SciencesStanford UniversityPalo Alto, [email protected]
ELARDUS ERASMUS
School of BiochemistryNorth-West UniversityPotchefstroomSouth [email protected]
ANDREAS ERHARDT
Department of Gastroenterology, Hepatology and InfectiousDiseasesHeinrich-Heine University of [email protected]
SEHSUVAR ERTÜRK
Department of NephrologyAnkara University School of [email protected]
JOAQUIN ESCRIBANO
Pediatric Nephrology UnitHospital Universitari Sant [email protected]
MICHAEL ESCUDIER
Department of Oral MedicineKings College London Dental InstituteLondonUK
DANIELA ESER
Department of PsychiatryLudwig-Maximilian-University [email protected]
MICHELLE M. ESTRELLA
Department of NephrologyJohns Hopkins University School of MedicineBaltimore, [email protected]
MARKUS ESZLINGER
III. Medical DepartmentUniversity of [email protected]
ANALEE J. ETHEREDGE
Institute of Biosciences and TechnologyTexas A&M University System Health Science CenterHouston, TXUSA
AMOS ETZIONI
Department of ImmunologyMeyer Children’s [email protected]
CEM EVEREKLIOGLU
Department of OphthalmologyErciyes University Medical [email protected]
DAVID B. EVERMAN
Greenwood Genetic CenterGreenwood, [email protected]
VINCENT EVERTS
Department. of Oral Cell BiologyAcademic Centre for DentistryUniversity of Amsterdam and VU University AmsterdamAmsterdamThe Netherlands
JUSTIN A. EZEKOWITZ
Division of CardiologyWalter Mackenzie CenterUniversity of AlbertaEdmonton, [email protected]
LYNETTE D. FAIRBANKS
Purine Research LaboratoryGuy’s [email protected],uk
MUHAMMAD FAIYAZ-UL-HAQUE
Department of GeneticsThe Hospital for Sick ChildrenToronto, [email protected]
ALBERTO FALCHETTI
Regional Center for Hereditary Endocrine TumoursDepartment of Internal MedicineUniversity of FlorenceFlorenceItaly
xxx List of Contributors
RONNIE FASS
Southern Arizona VAHealth Care System and Arizona HealthSciences CenterUniversity of ArizonaTucson, [email protected]
PAVEL FENCL
Department of Nuclear MedicinePET CentreNa Homolce HospitalPragueCzech [email protected]
PETER FERENCI
Department of Internal Medicine III, Gastroenterology andHepatologyVienna Medical [email protected]
ALBERTO FERLIN
Department of Histology, Microbiology and MedicalBiotechnologiesSection of Clinical Pathology and Centre for Male GameteCryopreservationUniversity of [email protected]
ATTEYET-ALLA FETOUH YASSIN
Institute of Medical Microbiology, Immunology andParasitologyFriedrich-Wilhelms-UniversityBonnGermanyyassin@mibi03.meb.uni-bonn.de
GIORA Z. FEUERSTEIN
Wyeth ResearchDiscovery Translational MedicineCollegeville, [email protected]
BÄRBEL FIEDLER
University of MuensterChildren’s HospitalMuensterGermany
JOSHUA FIERER
Division of Infectious Diseases, Department of MedicineUniversity of California at San DiegoSan Diego, [email protected]
DOMINIQUE FIGARELLA-BRANGER
Laboratoire de Biopathologie Nerveuse et MusculaireFaculté de Médecine de MarseilleMarseilleFranceDominique.Figarella-Branger@medecine.univ-mrs.fr
VOLKER FINGERLE
Bavarian Health and Food Safety [email protected]
JOHN W. FINLEY
USDA ARSGrand Forks Human Nutrition Research CenterGrand Forks, [email protected]
RICHARD H. FINNELL
Institute of Biosciences and TechnologyTexas A&M University System Health Science CenterHouston, TXUSA
JOSEF FINSTERER
ANTONELLA FIORAVANTI
Unit of RheumatologyDepartment of Clinical Medicine and ImmunologicalSciencesUniversity of [email protected]
TOBIAS W. FISCHER
Department of Dermatology, Venerology and AllergyUniversity Hospital Schleswig-HolsteinUniversity of [email protected]
AVI FISCHER
Division of Cardiac Electrophysiology and ArrhythmiaServiceMount Sinai Hospital and School of MedicineNew York, NYUSA
M. DOMINIK FISCHER
Centre for OphthalmologyInstitute for Ophthalmic ResearchUniversity TuebingenTuebingenGermany
List of Contributors xxxi
PAMELA FISCHER POSOVZSKY
Division of Pediatric Endocrinology and DiabetesUniversity of UlmUlmGermany
MONIKA FLECKENSTEIN
Department of OphthalmologyUniversity of BonnBonnGermany
THOMAS A. FLEISHER
Department of Laboratory MedicineClinical CenterNational Institute of Health, DHHSBethesda, [email protected]
JUSTINE H. S. FONG
Asian Medical CentreUniversity of Calgary Medical ClinicCalgary, ABCanada
BERTRAND FONTAINE
INSERMUniversité Pierre et Marie Curie, UMRParisFrance
CARLO FORESTA
Department of Histology, Microbiology and MedicalBiotechnologiesSection of Clinical Pathology and Centre for Male GameteCryopreservationUniversity of PadovaPadovaItaly
DOUGLAS FORREST
NIDDK, National Institutes of HealthBethesda, [email protected]
IRMGARD FÖRSTER
Institut für Umweltmedizinische Forschung gGmbHUniversity of [email protected]
FEDERICO FRACASSI
Dipartimento Clinico VeterinarioUniversità degli Studi di [email protected]
JEAN FRANCIS
Department of Internal MedicineHospital of St. RaphaelNew Haven, CTUSA
DIEGO FRANCO
Department of Experimental BiologyUniversity of [email protected]
JORGE FRANK
MUCMDUniversity Medical Center MaastrichtMaastrichtThe [email protected]
KAREL FRASCH
Department of Psychiatry IIUniversity of [email protected]
KENDALL S. FRAZIER
Safety AssessmentGlaxoSmithKlineKing of Prussia, [email protected]
ROGER A. FREEDMAN
Division of CardiologyUniversity of UtahSalt Lake City, [email protected]
BARRY I. FREEDMAN
Internal Medicine, Section on NephrologyWake Forest University School of MedicineWinston-Salem, [email protected]
NORBERT FREY
Department of CardiologyUniversity of [email protected]
GÉRARD FRIEDLANDER
INSERMUniversity of ParisParisFranceGé[email protected]
xxxii List of Contributors
THOMAS FRIELING
Medical Clinic IIHelios Klinikum KrefeldKrefeldGermanyto [email protected]
ANDREAS FRITSCHE
Department of Internal MedicineDivision of Endocrinology, Angiology, Nephrology andClinical ChemistryUniversity Hospital TuebingenTuebingenGermany
STEPHAN J. FROEHLICH
Eye ClinicLudwig-Maximilians-University [email protected]
EDWARD D. FROHLICH
Ochsner Clinic FoundationNew Orleans, LAUSA
MICHAEL FROMM
Clinical PhysiologyCampus Benjamin FranklinCharité[email protected]
PATRICK FROSK
Department of Biochemistry and Medical GeneticsUniversity of ManitobaWinnipeg, [email protected]
DIETMAR FUCHS
Department of Biological ChemistryBiocenterMedical-University of [email protected]
ARNO FUCHSHUBER
University Children’s [email protected]
TOSHIRO FUJITA
Department of Nephrology and EndocrinologyUniversity of Tokyo Graduate School of [email protected]
MASAFUMI FUKAGAWA
Division of Nephrology & Kidney CenterKobe University School of [email protected]
KEIICHI FUKUDA
Department of Regenerative Medicine and Advanced CardiacTherapeuticsKeio University School of [email protected]
GÉRARD GACON
Département de Génétique et DéveloppementInstitut CochinINSERMUniversité Paris [email protected]
WILLIAM A. GAHL
Section of Human Biochemical Genetics, Heritable DisordersBranchNational Human Genome Research InstituteBethesda, [email protected]
MARCIAL FRANCIS GALERA
Faculdade de MedicinaUniversidade de CuiabáCuiabáBrazil
NATALIE GALL
Department of Dermatology and AllergologyUniversity of UlmUlmGermany
CARLOS GALLIANI
Department of PathologyCook Children’s HospitalFort Worth, [email protected]
JÜRGEN GALLINAT
Department of Psychiatry and PsychotherapyCharité [email protected]
VICTOR M. GARCA NIETO
Pediatric Nephrology Unit, Hospital Ntra.Sra. de CandelariaSanta Cruz de TenerifeSpain
List of Contributors xxxiii
ANGELS GARCÍA-CAZORLA
Neurology DepartmentHospital Sant Joan de Dé[email protected]
HELENA M. GARDINER
Institute of Reproductive and Developmental BiologyFaculty of MedicineImperial CollegeQueen Charlotte’s and Chelsea [email protected]
SAURABH K. GARG
Department of Environmental and Biomolecular SystemsOGI School of Science and EngineeringOregon Health and Science UniversityBeaverton, ORUSA
GAETANO GARGIULO
Pediatric Cardiac Surgery UnitS. Orsola-Malpighi HospitalBolognaItaly
STANLEY M. GARTLER
Department of MedicineDivision of Medical GeneticsUniversity of WashingtonSeattle, WAUSA
THOMAS GASSER
Department of Neurodegnerative DiseasesHertie-Institute for Clinical Brain ResearchCenter of [email protected]
ZORAN GATALICA
Department of PathologyCreighton University School of MedicineOmaha, [email protected]
NORBERT GATTERMANN
Department of Hematology, Oncology and ClinicalImmunologyHeinrich-Heine-UniversityDuesseldorfGermanygattermann@med.uni-duesseldorf.de
MICHAEL A. GATZOULIS
Adult Congenital Heart Disease UnitRoyal Brompton and Harefield NHS [email protected]
MICHEL GAUTIER
Laboratoire de MicrobiologieUMR STLO, [email protected]
HANS-JÜRGEN GDYNIA
Department of NeurologyUniversity of [email protected]
KAREL GEBOES
Department of PathologyUniversity Hospital [email protected]
URBAN W. GEISTHOFF
Department of OtorhinolaryngologyHospitals of the City of CologneHNO [email protected]
DAVID S. GELLER
Section of NephrologyYale University School of MedicineNew Haven, [email protected]
DAVID GENEVIEVE
Département de GénétiqueINSERMHôpital Necker Enfants-MaladesParisFrance
MICHAEL T. GERAGHTY
Children’s Hospital of Eastern OntarioOttawa, [email protected]
IVOR L. GERBER
Department of CardiologyGreen Lane Cardiovascular ServiceAuckland City HospitalAuckland, AUKNew [email protected]
VICTOR E. A. GERDES
Department of Vascular MedicineAmsterdam Vascular Medicine GroupAcademic Medical CenterAmsterdamThe [email protected]
xxxiv List of Contributors
M. ERIC GERSHWIN
Division of Internal MedicineDepartment of Clinical Sciences ‘Luigi Sacco’University of [email protected]
CRISTINA GERVASINI
Division of Medical GeneticsSan Paolo School of MedicineUniversity of MilanMilanItaly
TAL GEVA
Department of CardiologyChildren’s HospitalBoston, [email protected]
ISMAT GHANEM
Department of Orthopedic SurgeryHotel-Dieu de France HospitalSaint Joseph [email protected]
PHILIP F. GIAMPIETRO
Department of Medical Genetic ServicesMarshfield ClinicMarshfield, [email protected]
VOLKMAR GIESELMANN
Institute for Physiological ChemistryUniversity [email protected]
RICHARD E. GILBERT
Keenan Research CentreLi Ka Shing Knowledge InstituteSt. Michael’s Hospital and University of TorontoToronto, [email protected]
JAMES M. GILCHRIST
Department of Clinical NeurosciencesBrown Medical SchoolProvidence, [email protected]
PERE GINÈS
University of [email protected]
ROBERTO GIORDA
Molecular Biology LaboratoryE. Medea Scientific InstituteBosisio Parini, LeccoItaly
SANTHOSH GIRIRAJAN
Departments of Pediatrics and Human GeneticsMedical College of Virginia CampusVirginia Commonwealth UniversityRichmond, VAUSA
GIAMPIERO GIROLOMONI
Department of Biomedical and Surgical SciencesSection of DermatologyUniversity of [email protected]
ADRIANA C. GITTENBERGER-DE GROOT
Department of Anatomy and EmbryologyLeiden University Medical CenterLeidenThe [email protected]
BENJAMIN GLASER
Endocrinology and Metabolism ServiceInternal Medicine DivisionHebrew University-Hadassah Medical [email protected]
PETER J. GOADSBY
Headache GroupDepartment of NeurologyUniversity of CaliforniaSan Francisco, [email protected]
HANS H. GOEBEL
Department of NeuropathologyJohannes-Gutenberg University Medical [email protected]
SERGIJ GOERDT
Department of Dermatalogy, Venereology and AllergologyUniversity Medical Centre MannheimRuprechts-Karls-University of [email protected]
ERIC GOFFIN
Departments of Nephrology and RadiologyCliniques Universitaires [email protected]
List of Contributors xxxv
LEV G. GOLDFARB
Department of Health and Human ServicesNational Institutes of HealthBethesda, [email protected]
ELIZABETH GOLDMUNTZ
Division of CardiologyChildren’s Hospital of PhiladelphiaPhiladelphia, [email protected]
NETA GOLDSCHMIDT
Hematology DepartmentHadassah – Hebrew University Medical [email protected]
DANIEL R. GOLDSTEIN
Department of Internal MedicineSection of Cardiovascular MedicineYale University School of MedicineNew Haven, [email protected]
RICARDO S. GOMEZ
Departments of Pharmacology and Oral PathologyUniversidade Federal de Minas GeraisBelo HorizonteBrazil
PHILLIP GORDEN
National Institute of Diabetes and Digestive and KidneyDiseasesNational Institutes of HealthBethesda, [email protected]
GEORG GOSZTONYI
Institute of NeuropathologyCharité – University Medicine [email protected]
YU-ICHI GOTO
Department of Mental Retardation and Birth Defect ResearchNational Center of Neurology and PsychiatryKodaira, [email protected]
ROBERT W. GOTSHALL
Health and Exercise ScienceColorado State UniversityFort Collins, [email protected]
HULYA ILIKSU GOZU
Section of Endocrinology and MetabolismDr. Lutfi Kirdar Kartal Education and Research [email protected]
JÜRGEN GRABBE
Department of DermatologyMedical University of [email protected]
STEPHAN GRABBE
Department of DermatologyJohannes-Gutenberg-University [email protected]
DONATELLA GRANCHI
Laboratorio di Fisiopatologia degli Impianti OrtopediciIstituto Ortopedico [email protected]
BERNARD GRANDCHAMP
Service de Biochimie BHôpital [email protected]
ALEXEI GRATCHEV
Department of Dermatalogy, Venereology and AllergologyUniversity Medical Centre MannheimRuprechts-Karls-University of HeidelbergMannheimGermany
TRACEY D. GRAVES
Centre for Neuromuscular DiseaseNational Hospital for Neurology and NeurosurgeryDepartment of Molecular NeuroscienceInstitute of NeurologyLondonUK
CHERYL R. GREENBERG
Department of Biochemistry and Medical GeneticsUniversity of ManitobaWinnipeg, [email protected]
ALMUT GRENZ
Mucosal Inflammation ProgramDepartment of Anesthesiology and Perioperative MedicineUniversity of Colorado Health Sciences CenterDenver, COUSA
xxxvi List of Contributors
OLAV A. GRESSNER
Institute of Clinical Chemistry and PathobiochemistryBWTH University [email protected]
BODO GRIMBACHER
Department of Immunology and Molecular PathologyRoyal Free Hospital and University College Medical [email protected]
HERMANN-JOSEF GRÖNE
Department of Cellular and Molecular PathologyGerman Cancer Research CenterUniversity of [email protected]
ROBERT F. GROFF IVDepartment of NeurosurgeryUniversity of PennsylvaniaPhiladelphia, PAUSA
TILMAN GRUNE
Institute of Biological Chemistry and NutritionBiofunctionality and Safety of FoodUniversity [email protected]
FABRIZIO GUARNERI
Institute of DermatologyPoliclinico UniversitarioMessinaItaly
IRENE GUERRINI
Molecular Psychiatry LaboratoryWindeyer Institute of Medical SciencesDepartment of Psychiatry and Behavioural SciencesRoyal Free and University College LondonLondon Medical [email protected]
RENZO GUERRINI
Pediatric Neurology and Neurogenetics Unit and LaboratoriesChildren’s Hospital A.MeyerUniversity of [email protected]
JEAN-MARC GUETTIER
National Institute of Diabetes and Digestive and KidneyDiseasesNational Institutes of HealthBethesda, [email protected]
MÓNICA GUEVARA
University of BarcelonaIDIBAPSBarcelonaSpain
OLIVIER GUILBAUD
Université René DescartesParisFrance
PER GULDBERG
Danish Center for Human Genome ResearchJohn F. Kennedy InstituteGlostrupDenmark
ORLANDO GUNTINAS-LICHIUS
Department of OtorhinolaryngologyFriedrich-Schiller-UniversityJenaGermanyorlando.guntinas@med.uni-jena.de
SEFIK GURAN
Department of Medical BiologyGulhane Medical [email protected]
PAVEL GUREVICH
Laboratory of Experimental MedicineRehovotIsrael
HUGH M. GURLING
Molecular Psychiatry LaboratoryWindeyer Institute of Medical SciencesDepartment of Psychiatry and Behavioural SciencesRoyal Free and University College LondonLondon Medical [email protected]
ANGELIKA GUTENBERG
Department for NeurosurgeryGeorg-August-UniversityGoettingenGermanyagutenb1@jhmi.edu
List of Contributors xxxvii
FLEMMING GÜTTLER
Danish Center for Human Genome ResearchJohn F. Kennedy [email protected]
YENER GÜZELCAN
Reinier van Arkel Group/Jeroen Bosch HospitalDepartment of Psychiatry‘s-HertogenboschThe [email protected]
BIRGIT HAACK
Department of Molecular PathologyUniversity Hospital of [email protected]
JOOST HAAN
Department of NeurologyRijnland Hospital/Leiden University Medical CentreLeidenThe [email protected]
STEPHAN L. HAAS
Department of Medicine II (Gastroenterology, Hepatologyand Infectious Diseases)University Hospital of Heidelberg at [email protected]
PIRMIN HABERMEHL
Pediatric University HospitalJohannes-Gutenberg [email protected]
JOHANNES HÄBERLE
University Hospital of [email protected]
PETER HACKMAN
Department of Medical GeneticsVaasa Central HospitalUniversity of HelsinkiHelsinkiFinland
GEORGIOS M. HADJIGEORGIOU
Department of Neurology, School of MedicineUniversity of [email protected]
CLAUDIA HAFERLACH
Munich Leukemia Laboratory (MLL)MunichGermany
TORSTEN HAFERLACH
Munich Leukemia Laboratory (MLL)MunichGermany
SAMER EL HAGE
Department of Orthopedic SurgeryHotel-Dieu de France HospitalSaint Joseph UniversityBeirutLebanon
ANDREAS HAHN
Department of Pediatric NeurologyChildren’s Medical CenterUniversity of Giessen and [email protected]
ANGELIKA F. HAHN
Department of NeurologyUniversity of Western OntarioLondon Health Science CentreLondon, [email protected]
AHMET MESRUR HALEFOĞLU
Department of RadiologyŞişli Etfal Training and Research HospitalŞişli, İ[email protected]
TAKAHIRO HAMADA
Department of DermatologyKurume University School of MedicineKurume, [email protected]
RIIKKA H. HÄMÄLÄINEN
Folkhälsan Institute of Genetics and Neuroscience CenterUniversity of [email protected]
CHRISTIAN HAMEL
CHU MontpellierCentre of Reference for Genetic Sensory [email protected]
xxxviii List of Contributors
LENNART HAMMARSTÖM
Karolinska InstituteDepartment of Laboratory MedicineKarolinska University Hospital [email protected]
C. OLIVER HANEMANN
Clinical NeurobiologyInstitute of Biomedical and Clinical SciencePeninsula Medical SchoolTamar Science Park, [email protected]
MICHAEL G. HANNA
Centre for Neuromuscular DiseaseNational Hospital for Neurology and NeurosurgeryDepartment of Molecular NeuroscienceInstitute of [email protected]
R. SCOTT HANSEN
Department of Genome SciencesUniversity of WashingtonSeattle, WAUSA
ANN-SOFIE HANSSON
Department of Clinical ImmunologySahlgrenska University [email protected]
NAOKI HARADA
Kyusyu Medical Science Nagasaki LaboratoryNagasakiJapan
RICHARD W. HARPER
MonashHeartMonash Medical CentreMelbourne, [email protected]
MATTHEW HARRIES
Dermatology CentreUniversity of ManchesterHope HospitalManchesterUK
JEFFREY P. HARRIS
Department of Otolaryngology/Head and Neck SurgeryUniversity of CaliforniaSan Diego School of MedicineLa Jolla, CAUSA
JAMES C. HARRIS
Johns Hopkins University Medical SchoolBaltimore, MDUSA
THOMAS C. HART
National Institute of Dental and Cranio-Facial ResearchNational Institutes of HealthBethesda, MDUSA
INGA HARTING
Department of NeuroradiologyUniversity of Heidelberg Medical [email protected]
ARNDT HARTMANN
Department of PathologyUniversity [email protected]
BRANDY J. HARVEY
Department of Cell Biology and BiochemistryTexas Tech University Health Sciences CenterLubbock, TXUSABrandy [email protected]
GERD HASENFUSS
HerzzentrumGeorg-August-University [email protected]
AKMAL HASSAN
Clinic of DermatologyHeinrich-Heine-UniversityDuesseldorfGermany
SYED HASSAN
Elipsis BiotherapeuticsToronto, [email protected]
NAN HATCH
Department of OrthodonticsUniversity of MichiganAnn Arbor, [email protected]
DIETER HÄUSSINGER
Clinic for Gastroenterology, Hepatology and InfectiologyHeinrich-Heine-UniversityDuesseldorfGermanyhaeussin@uni-duesseldorf.de
List of Contributors xxxix
THOMAS HAWRANEK
Department of DermatologyParacelsus Private Medical UniversitySalzburgAustria
RITVA HÄYRINEN-IMMONEN
Vantaa Dental [email protected]
S. DIANE HAYWARD
Viral Oncology ProgramSidney Kimmel Cancer CenterJohns Hopkins UniversityBaltimore, [email protected]
DENIS J. HEADON
University of [email protected]
HARDALLY R. HEGDE
Department of PediatricsAlberta Children’s HospitalThe University of CalgaryCalgary, ABCanada
RICHARD G. HEGELE
Department of Pathology and Laboratory MedicineUniversity of British ColumbiaVancouver, [email protected]
ULRICH HEININGER
University Children’s [email protected]
TOBIAS HEINTGES
Clinic for Gastroenterology, Hepatology and InfectiologyHeinrich-Heine-University [email protected]
MIEP HELFRICH
Bone Research ProgrammeSchool of Medicine and DentistryInstitute of Medical SciencesForesterhill, [email protected]
JAN HELLEMANS
Center for Medical GeneticsGhent University [email protected]
GEOFFREY N. HENDY
Calcium Research Laboratory, Royal Victoria Hospital, andDepartments of Medicine, Physiology and Human GeneticsMcGill UniversityMontreal, [email protected]
HARTMUT HENGEL
Institute for VirologyHeinrich-Heine-UniversityDuesseldorfGermanyHartmut.Hengel@uni-duesseldorf.de
MARKUS HENGSTSCHLÄGER
Medical Genetics, Obstetrics and GynecologyMedical University of [email protected]
RAOUL C. M. HENNEKAM
Department of PediatricsAcademic Medical CenterUniversity of AmsterdamAmsterdamThe [email protected]
WERNER J. HEPPT
Department of OtorhinolaryngologyKlinikum [email protected]
DAVID N. HERRMANN
Departments of Neurology and PathologyUniversity of RochesterRochester, [email protected]
MICHAEL S. HERSHFIELD
Department of BiochemistryDuke University Medical CenterDurham, [email protected]
ALBRECHT HESSE
Department of UrologyUniversity of [email protected]
xl List of Contributors
REINOUT P. HESSELINK
PharmacellMaastrichtThe [email protected]
PETER HEUTINK
Department of Clinical GeneticsVU University Medical CenterAmsterdamThe [email protected]
WHITNEY A. HIGH
Departments of Dermatology and PathologyUniversity of Colorado School of MedicineDenver, [email protected]
FRIEDHELM HILDEBRANDT
Department of PediatricsUniversity of MichiganAnn Arbor, [email protected]
DENISE S. HILL
Interdisciplinary Faculty of ToxicologyTexas A&M UniversityCollege Station, TXUSA
JAN-LUUK HILLEBRANDS
Department of Cell Biology, Immunology SectionUniversity Medical Center GroningenGroningenThe [email protected]
HELMUT HINTNER
Department of DermatologyParacelsus Private Medical [email protected]
SHIRLEY HODGSON
Department of Cancer GeneticsSt. George’s HospitalUniversity of [email protected]
ERIC P. HOFFMAN
Research Center for Genetic MedicineChildren’s National Medical CenterGeorge Washington UniversityWashington, [email protected]
MICHAEL M. HOFFMANN
Division of Clinical ChemistryUniversity Hospital FreiburgFreiburg i. [email protected]
SILKE HOFMANN
Department of DermatologyUniversity Medical [email protected]
MARY H. HOHENHAUS
Department of MedicineBrown University/The Miriam HospitalProvidence, [email protected]
BERND HOHENSTEIN
Department of Nephrology and HypertensionUniversity Erlangen-NurembergErlangenGermany
HAZEL M. HOLDEN
Department of BiochemistryUniversity of WisconsinMadison, [email protected]
STEPHEN T. HOLGATE
Southampton General HospitalUniversity of [email protected]
STEVEN HOLLAND
NIH Clinical CenterBethesda, MAUSA
ARE MARTIN HOLM
Section of Clinical Immunology and Infectious DiseasesMedical DepartmentRikshospitalet University [email protected]
IAN HOLT
MRC-Dunn Human Nutrition [email protected]
FRANK G. HOLZ
Department of OphthalmologyUniversity of BonnBonnGermany
List of Contributors xli
MARINELLA HOLZHAUSEN
Department of Pharmacology and TherapeuticsThe University of CalgaryCalgary, [email protected]
KAM-LUN ELLIS HON
Department of PediatricsPrince of Wales HospitalHong Kong Special Administrative RegionPeople’s Republic of China
AKIRA HONDA
Center for Collaborative ResearchTokyo Medical UniversityKasumigaura [email protected]
TAKAYUKI HONDA
Department of Laboratory MedicineShinshu University School of [email protected]
BERND HOPPE
University Children’s HospitalUniversity of [email protected]
SEVAN HOPYAN
Hospital for Sick Children, Division of Orthopedics andProgram in Developmental and Stem Cell BiologyUniversity of TorontoToronto, [email protected]
JULIA HORN
Division of Rheumatology and Clinical ImmunologyUniversity Hospital [email protected]
JASON H. HUANG
Department of NeurosurgeryUniversity of PennsylvaniaPhiladelphia, [email protected]
TING-TING HUANG
Department of PediatricsUniversity of CaliforniaSan Francisco, CAUSA
CHRISTIAN P. M. HUGO
Department of Nephrology and HypertensionUniversity Erlangen-NurembergErlangenGermanychristian.hugo@rzmail.uni-erlangen.de
WILGARD HUNGER-DATHE
Department of Internal Medicine IIIUniversity Hospital JenaJenaGermany
NEIL HUNTER
Institute of Dental ResearchWestmead Millennium Institute and Westmead Centre forOral HealthWestmead HospitalWestmead, [email protected]
PETER HUPPKE
Department of Pediatric NeurologyGeorg-August [email protected]
KHALID HUSSAIN
Great Ormond Street Children’s Hospital NHS Trust and theInstitute of Child HealthUnit of BEMUniversity [email protected]
MARY REDMOND HUTSON
Department of Pediatrics, NPRIDuke UniversityDurham, [email protected]
JAMES HYLAND
Department of PathologyCenter for Gene TherapyTulane University Health Sciences CenterNew Orleans, [email protected]
MOFID IBRAHEIM
Department of Obstetrics and GynecologyBasildon University [email protected]
xlii List of Contributors
OMAR A. IBRAHIMI
Department of DermatologyHarvard Medical SchoolBoston, [email protected]
HIROSHI ICHINOSE
Department of Life ScienceGraduate School of Bioscience and BiotechnologyTokyo Institute of [email protected]
AMAJ IKOMI
Department of Obstetrics and GynaecologyBasildon University HospitalBasildonUK
MASSIMO IMAZIO
Cardiology DepartmentMaria Vittoria [email protected]
KEI INAI
Department of Pediatric CardiologyTokyo Women`s Medical [email protected]
ADIBA ISADepartment of Clinical ImmunologyCenter for Stem Cell TreatmentOdense University HospitalUniversity of Southern [email protected]
WULF ITOHeartcenter, CardiologyUniversity Hospital Hamburg-EppendorfHamburgGermany
EIJI ITOI
Department of Orthopedic SurgeryTohoku University School of [email protected]
SUDHA K. IYENGAR
Epidemiology and BiostatisticsOphthalmology and GeneticsCase Western Reserve UniversityCleveland, [email protected]
GIRIS JACOB
Recanati Autonomic Dysfunction CenterRambam Medical CenterHaifa Israel and the Autonomic Dysfunction CenterVanderbilt UniversityNashville, TNUSA
NICHOLAS A. JACQUES
Institute of Dental ResearchWestmead Millennium Institute and Westmead Centre forOral HealthWestmead HospitalWestmead, [email protected]
JAAK JAEKEN
Department of PediatricsCenter for Metabolic DiseaseUniversity of [email protected]
MARKUS JÄGER
Department of Psychiatry IIUniversity of UlmGuenzburgGermany
MICHAELA JAKSCH
Freiburg Medical LaboratoryMiddle East [email protected]
HANNU JALANKO
Hospital for Children and AdolescentsUniversity of [email protected]
ANDREAS JANECKE
Division of Clinical GeneticsInnsbruck Medical [email protected]
PETER L. M. JANSEN
Department of Gastroenterology and HepatologyAcademic Medical CenterAmsterdamThe [email protected]
KATRIEN JANSSENS
Department of Medical GeneticsUniversity of AntwerpAntwerpBelgium
List of Contributors xliii
MICHAEL A. JANTZ
Division of Pulmonary and Critical Care MedicineUniversity of FloridaGainesville, [email protected]
JEAN-MICHEL ROZET
Unité de Recherches Génétique et Epigénétique des MaladiesMétaboliques, Neurosensorielles et du DéveloppementINSERMHôpital des Enfants [email protected]
WILLIAM JEFFCOATE
Foot Ulcer Trials UnitDepartment of Diabetes and EndocrinologyCity [email protected]
VIVEKANAND JHA
Department of NephrologyPostgraduate Institute of Medical Education and [email protected]
RUI-CHENG JIDepartment of Anatomy, Biology and MedicineOita [email protected]
QIUJIE JIANG
Department of Dermatology and Cutaneous BiologyJefferson Medical CollagePhiladelphia, [email protected]
SERGIO A. JIMENEZ
Jefferson Institute of Molecular Medicine and Division ofConnective Tissue DiseasesDepartment of Dermatology and Cutaneous BiologyThomas Jefferson UniversityPhiladelphia, [email protected]
LING JING
Institute of Endemic DiseasesNorman Bethune College of Medical SciencesJilin UniversityChangchunP.R. [email protected]
HYDER A. JINNAH
Johns Hopkins University Medical SchoolBaltimore, [email protected]
MARTIN T. JOHN
St. Vincent’s Institute of Medical ResearchMelbourne, [email protected]
COLIN A. JOHNSON
Section of Ophthalmology and NeurosciencesLeeds Institute of Molecular MedicineSt James’s University [email protected]
GRAEME JONES
Musculoskeletal UnitMenzies Research InstituteHobart, [email protected]
FRANÇOIS JOURET
Division of NephrologyUniversité Catholique de [email protected]
KARIN JURKAT-ROTT
Department of Applied PhysiologyUlm [email protected]
PRADEEP V. KADAMBI
Section of NephrologyUniversity of ChicagoChicago, ILUSA
JENS J. KADEN
1st Department of MedicineFaculty of Clinical MedicineUniversity of Heidelberg at [email protected]
RICHARD J. KAHNOSKI
Department of UrologySpectrum HealthGrand Rapids, MIUSA
xliv List of Contributors
ZBIGNIEW KALARUS
First Department of CardiologySilesian Medical SchoolSilesian Center for Heart [email protected]
JONATHAN M. KALMAN
Department of CardiologyRoyal Melbourne HospitalUniversity of MelbourneMelbourne, VICAustralia
DEEPAK KAMAT
Carman and Ann Adams Department of PediatricsInstitute of Medical EducationChildren’s Hospital of MichiganDetroit, [email protected]
HIDETO KAMEDA
Division of Rheumatology/Clinical ImmunologyDepartment of Internal MedicineSaitama Medical CenterSaitama Medical [email protected]
NADA KANAAN
Departments of Nephrology and RadiologyCliniques Universitaires [email protected]
HO SUNG KANG
Department of Molecular BiologyCollege of Natural SciencesPusan National [email protected]
Y. JAMES KANG
Departments of Medicine, Pharmacology and ToxicologyUniversity of Louisville School of MedicineLouisville, [email protected]
BHARAT K. KANTHARIA
Division of Cardiac ElectrophysiologyThe University of Texas Health Science CenterHouston, [email protected]
CHAM PION KAO
Department of PediatricsAlberta Children’s HospitalThe University of CalgaryCalgary, ABCanada
BRUCE KAPLAN
University of Illinois at Chicago Transplant CenterChicago, [email protected]
HENRY J. KAPLAN
Department of Ophthalmology and Visual SciencesUniversity of LouisvilleLouisville, [email protected]
JOSSELINE KAPLAN
Unité de Recherches Génétique et Epigénétique des MaladiesMétaboliques, Neurosensorielles et du DéveloppementINSERMHôpital des Enfants MaladesParisFrance
KEVIN KAPLAN
NYU Hospital for Joint DiseasesNew York, NYUSA
TAKATOSHI KASAI
Department of CardiologyJuntendo University, School of [email protected]
CLIFFORD E. KASHTAN
Department of PediatricsUniversity of Minnesota Medical SchoolMinneapolis, [email protected]
SURENDER KASHYAP
Department of Pulmonary MedicineIndira Gandhi Medical [email protected]
JAN KASSUBEK
Department of NeurologyUniversity of [email protected]
List of Contributors xlv
HIDEKI KATO
Division of Nephrology and EndocrinologyUniversity of Tokyo School of [email protected]
SHOICHI KATSURAGI
National Kikuchi [email protected]
DIETER KAUFMANN
Department of Human GeneticsUniversity of [email protected]
RAILI KAUPPINEN
Porphyria Research CentreBiomedicum-HelsinkiUniversity of [email protected]
UNER KAYABAS
Department of Infectious DiseasesFaculty of MedicineInonu UniversityMalatyaTurkey
MICHAEL P. KEANE
Department of MedicineUniversity of Virginia School of MedicineCharlottesville, VAUSA
REJIN KEBUDI
Division of Pediatric Hematology-OncologyOncology InstituteIstanbul [email protected]
JAMES C. KEITH, JR.Wyeth ResearchDiscovery Translational MedicineCollegeville, [email protected]
ELIZABETH M. KEITHLEY
Department of Otolaryngology, Head and Neck SurgeryUniversity of California, San Diego School of MedicineLa Jolla, [email protected]
JUTTA KELLER
Medical Department, Israelitic HospitalAcademic Hospital of the University of [email protected]
NANCY R. KELLER
Autonomic Dysfunction CenterVanderbilt UniversityNashville, [email protected]
ANDREA KELLY
Division of EndocrinologyChildren’s Hospital of PhiladelphiaUniversity of Pennsylvania School of MedicinePhiladelphia, [email protected]
WERNER KEMPF
Department of DermatologyUniversity Hospital [email protected]
STEPHAN DISEAN KENDALL
Medicine, Pharmacology and Cancer BiologyDuke UniversityDurham, [email protected]
NIR KFIR
Tel Hai CollegeSchool of Bio-TechnologyUpper [email protected]
MOHAMMAD KHALID
Pulmonary Section, Department of MedicineKing Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia
MARKUS KHALIL
Department of Pediatric CardiologyUniversity Hospital of [email protected]
STEFAN KIECHL
Department of NeurologyUniversity Clinic [email protected]
xlvi List of Contributors
KIRSTY KIEZEBRINK
University of [email protected]
STEFAN KINS
ZMBHUniversity of [email protected]
MARGARET L. KIRBY
Department of Pediatrics, NPRIDuke UniversityDurham, [email protected]
GUDULA KIRTSCHIG
Department of DermatologyVU Medical CentreAmsterdamThe [email protected]
JÖRG KLEEFF
Department of General SurgeryUniversity of [email protected]
CHRISTINE KLEIN
Department of NeurologyUniversity of [email protected]
PETER KLEIN
Department of SurgeryUniversity of Erlangen-NurembergErlangenGermanypeter.klein@chir.imed.uni-erlangen.de
PHILIP J. KLEMMER
Division of Nephrology and HypertensionUniversity of North Carolina School of MedicineChapel Hill, [email protected]
STEFAN KÖLKER
Department of General Pediatrics, Division of InbornMetabolic DiseasesUniversity Children’s [email protected]
THOMAS KLOCKGETHER
Department of NeurologyUniversity Hospital [email protected]
THOMAS KLOPSTOCK
Department of NeurologyFriedrich-Baur-Institute and Ludwig-Maximilians-University [email protected]
JOCHEN KLUCKEN
Department of NeurologyUniversity of [email protected]
URSULA KNIRSCH
ALS-ClinicKantonsspital St. GallenSt. [email protected]
WOLFRAM TRUDO KNOEFEL
Department of General-, Visceral- and Pediatric SurgeryUniversity Hospital DuesseldorfHeinrich-Heine-UniversityDuesseldorfGermanyknoefel@med.uni-duesseldorf.de
RALPH KNÖLL
Cardiovascular Molecular GeneticsGeorg-August-University [email protected]
THOMAS KNOLL
Department of UrologyMannheim University [email protected]
MARKUS KNUF
Pediatric University HospitalJohannes-Gutenberg UniversityMainzGermany
ALAN P. KNUTSEN
Division of Allergy/ImmunologyDepartment of PediatricsSaint Louis University Health Sciences CenterSt. Louis, [email protected]
List of Contributors xlvii
CHRISTIAN A. KOCH
Division of EndocrinologyUniversity of Mississippi Medical CenterJackson, [email protected]
NORMAN KOCK
Department of NeurologyUniversity of [email protected]
RICHARD KOCH
Department of GeneticsChildren’s Hospital Los AngelesLos Angeles, [email protected]
MICHAEL KOENEN
MPI for Medical [email protected]
SUSANNE KOHL
Molecular Genetics LaboratoryInstitute for Ophthalmic ResearchCenter for OphthalmologyUniversity of [email protected]
JÜRGEN KOHLHASE
Center for Human [email protected]
RÜDIGER KÖHLING
Institute of PhysiologyUniversity of [email protected]
ALFRIED KOHLSCHÜTTER
Department of PediatricsUniversity Medical Center [email protected]
JOSEF KÖHRLE
EnForCéCharité University HospitalBerlinGermany
GEORG KOJDA
Institute for Pharmacology and Clinical PharmacologyUniversity Clinic DuesseldorfDuesseldorfGermany
ZDENEK KOLAR
Department of Pathology and Laboratory of MolecularPathologyPalacky UniversityOlomoucCzech [email protected]
GENOVEFA D. KOLOVOU
First Cardiology DepartmentOnassis Cardiac Surgery [email protected]
THOMAS KOLTER
LIMES Program Unit Membrane Biology & LipidBiochemistryKekulé-InstituteUniversity BonnBonnGermany
TATSURO KONDOH
Department of PediatricsNagasaki University School of [email protected]
BRUCE C. KONE
Departments of Internal Medicine and Integrative Biology,Pharmacology and PhysiologyThe University of Texas Medical School at HoustonHouston, [email protected]
YRJÖ KONTTINEN
Department of MedicineBiomedicum, University of [email protected]
JÜRGEN KOPITZ
Institute of PathologyUniversity of HeidelbergHeidelbergGermany
PETER KOPP
Feinberg School of MedicineNorthwestern UniversityChicago, ILUSA
xlviii List of Contributors
CENGIZ KORKMAZ
Department of Internal MedicineEskisehir Osmangazi [email protected]
JOHANNES KORNHUBER
Department of Psychiatry and PsychotherapyUniversity of Erlangen Medical SchoolErlangenGermanyjohannes.kornhuber@psych.imed.uni-erlangen.de
YU RU KOU
Department of Physiology, School of MedicineNational Yang-Ming [email protected]
OSKAR KOWALSKI
First Department of CardiologySilesian Medical SchoolSilesian Center for Heart DiseaseZabrzePoland
ZAKI KRAIEM
Faculty of MedicineTechnionHaifaIsrael
SABINE KRAUSE
Friedrich-Baur-Institute and Department of NeurologyLudwig-Maximilians-UniversityMunichGermanySabine.Krause@med.uni-muenchen.de
MARIA-T. KRAUTH
Division of Hematology and HemostaseologyDepartment of Internal Medicine IMedical University [email protected]
THOMAS KRIEG
Department of DermatologyUniversity [email protected]
GABRIELE A. KROMBACH
Department of Diagnostic RadiologyUniversity [email protected]
ABHIJIT V. KSHIRSAGAR
Division of Nephrology and HypertensionUniversity of North Carolina School of MedicineChapel Hill, [email protected]
RALF KUBITZ
Clinic for Gastroenterology, Hepatology and InfectiologyHeinrich-Heine-UniversityDuesseldorfGermanykubitz@med.uni-duesseldorf.de
KAROLINA KUBLICKIENE
Department of Obstetrics and GynecologyKarolinska University HospitalStockholmSweden
RENATA KUCEROVA
Department of DermatovenerologyPalacky University and University HospitalOlomoucCzech [email protected]
WOLFGANG KÜHN
Department of NephrologyUniversity Medical Center [email protected]
RAJIV KUMAR
Department of Internal MedicineMayo Clinic and FoundationRochester, [email protected]
RAKESH KUMAR
Department of SurgeryAll India Institute of Medical SciencesNew DelhiIndia
KARL KUNZELMANN
Department of PhysiologyUniversity of [email protected]
SUSAN KUPKA
Department of General, Visceral and Transplant SurgeryUniversity Hospital of [email protected]
List of Contributors xlix
SHIGEO KURE
Department of Medical GeneticsTohoku University School of MedicineSendaiJapan
GERHARD KURLEMANN
University of MuensterChildren’s [email protected]
NAOTO KURODA
Department of Pathology and Clinical LaboratoryKochi Red Cross [email protected]
SIM KUTLAY
Department of NephrologyAnkara University School of MedicineAnkaraTurkey
SHARON LA FONTAINE
Centre for Cellular and Molecular BiologySchool of Life and Environmental SciencesDeakin UniversityBurwood, [email protected]
CARLO A. LACKERBAUER
Eye ClinicLudwig-Maximilians-University MunichMunichGermany
KAR NENG LAI
Department of MedicineThe University of Hong KongHong [email protected]
NIGEL G. LAING
Molecular Neurogenetics LabUniversity of Western AustraliaCentre for Medical ResearchQueen Elizabeth II Medical CentreNedlands, [email protected]
SEEMA R. LALANI
Department of Molecular and Human GeneticsBaylor College of MedicineHouston, [email protected]
BENOÎT LAMARCHE
Institute on Nutraceuticals and Functional FoodsLaval UniversityQuébec, [email protected]
FRANK LAMMERT
Department of Internal Medicine IUniversity Hospital [email protected]
VALÉRIA LAMOUNIER-ZEPTER
Medical Clinic IIIUniversity of [email protected]
ANNE KATRIN LAMPE
South East of Scotland Clinical Genetic ServiceWestern General [email protected]
KATJA LAMPINEN
Department of Obstetrics and GynecologyKarolinska University [email protected]
RISTO KAAJA
Department of Obstetrics and GynecologyHelsinki University [email protected]
RADOSŁAW LENARCZYK
First Department of CardiologySilesian Medical SchoolSilesian Center for Heart [email protected]
DANIEL LANDAU
Department of PediatricsSoroka University Medical CenterBeer [email protected]
G. BERNHARD LANDWEHRMEYER
Department of NeurologyUlm [email protected]
l List of Contributors
FLORIAN LANG
Department of PhysiologyUniversity of [email protected]
GABRIELE E. LANG
University Eye Hospital [email protected]
KARL S. LANG
Ontario Cancer InstituteUniversity Health NetworkToronto, ONCanada
UNDINE E. LANG
Department of Psychiatry and PsychotherapyCharité University Medicine [email protected]
LIDIA LARIZZA
Division of Medical GeneticsSan Paolo School of MedicineUniversity of [email protected]
A. J. LARNER
Cognitive Function ClinicWalton Centre for Neurology and [email protected]
ZVI LARON
Schneider Children’s Medical CenterPetah Tikva/Tel [email protected]
HENRIK LARSSON
Department of Medical Epidemiology and BiostatisticsKarolinska [email protected]
SYLVAIN LATOUR
INSERMHôpital [email protected]
LARRY LATSON
Department of Pediatric CardiologyCleveland Clinic FoundationCleveland, [email protected]
ELANA LAVINE
Division of Immunology and AllergyThe Hospital for Sick ChildrenToronto, ONCanada
YVES LE LOIR
Laboratoire de MicrobiologieUMR STLO, [email protected]
MARTINE LE MERRER
Département de GénétiqueINSERMHôpital Necker [email protected]
ALEXANDER LEAF
Harvard Medical SchoolCharlestown, [email protected]
LINDA LEATHERBURY
Children’s National Medical CenterCGMRWashington, DCUSA
MAXIMILIAN LEDOCHOWSKI
Department of Nutritional MedicineMedical University of [email protected]
CHAEYOUNG LEE
Ilsong Institute of Life ScienceHallym UniversityAnyangSouth [email protected]
JYH-YEUAN LEE
Department of Cell Biology and BiochemistryTexas Tech University Health Sciences CenterLubbock, [email protected]
List of Contributors li
RICHARD S. LEGRO
Department of Obstetrics and GynecologyCollege of MedicinePennsylvania State UniversityHershey, [email protected]
ANNA-ELINA LEHESJOKI
Folkhälsan Institute of Genetics and Neuroscience CenterUniversity of [email protected]
FRANK LEHMANN-HORN
Department of Applied PhysiologyUlm [email protected]
MICHAEL J. LENARDO
Molecular Development SectionLaboratory of ImmunologyNIAID, NIHBethesda, [email protected]
JAMES V. LEONARD
Clinical and Molecular Genetics UnitInstitute of Child HealthUniversity College [email protected]
NORMA LEONARD
Department of Medical GeneticsStollery Children’s HospitalUniversity of AlbertaEdmonton, ABCanada
PHILIPP M. LEPPER
Department of Intensive Care MedicineInselspitalUniversity of BernBernSwitzerland
HOLGER LERCHE
Departmemts of Neurology and Applied PhysiologyUniversity of [email protected]
DEREK LEROITH
Division of Endocrinology,Diabetes and Bone DiseasesMount Sinai School of MedicineNew York, [email protected]
MARGHERITA LERONE
Laboratory of Molecular GeneticsG. Gaslini Institute, Department of PediatricsUniversity of GenovaGenovaItaly
KLAUS-PETER LESCH
Molecular and Clinical PsychobiologyDepartment of Psychiatry and PsychotherapyUniversity of [email protected]
ALEXANDER A. C. LEUNG
Department of MedicineThe University of AlbertaEdmonton, [email protected]
ALEXANDER K. C. LEUNG
Department of PediatricsAlberta Children’s HospitalThe University of CalgaryCalgary, [email protected]
KLAUS LEY
Robert M. Berne Cardiovascular Research Center andDepartments of Biomedical Engineering, MolecularPhysiology and Biological PhysicsUniversity of VirginiaCharlottesville, [email protected]
CHRISTINE LIANG
Department of DermatologyNew York University School of MedicineNew York, NYUSA
CHANGHONG LI
Division of Endocrinology, Children’s Hospital ofPhiladelphiaUniversity of Pennsylvania School of MedicinePhiladelphia, PAUSA
lii List of Contributors
GUANG-SHENG LI
Institute of Endemic DiseasesNorman Bethune College of Medical SciencesJilin UniversityChangchunP.R. [email protected]
JIANG LI
Medical Clinic IIIMedical Faculty Carl Gustav CarusTechnical University DresdenDresdenGermany
CHRISTOPH LICHT
Department of NephrologyThe Hospital for Sick ChildrenToronto, [email protected]
VOLKER LIEBE
1st Department of MedicineFaculty of Clinical MedicineMannheim University of [email protected]
KATRINA LIGHT
Department of Psychological MedicineChristchurch School of Medicine and Health SciencesUniversity of OtagoChristchurchNew [email protected]
RICHARD W. LIGHT
Division of Allergy, Pulmonary, and Critical Care MedicineVanderbilt UniversityNashville, [email protected]
XIAOBO LIN
Washington University in St. LouisSchool of MedicineSt. Louis, MIUSA
YOU SHUEI LIN
Department of PhysiologyTaipei Medical [email protected]
KATRIN S. LINDENBERG
Department of NeurologyUlm [email protected]
MALIN LINDSTEDT
Department of ImmunotechnologyLund [email protected]
DANIEL C. LINK
Division of OncologyDepartment of MedicineWashington UniversitySt. Louis, [email protected]
DANAE LIOLITSA
Centre for Neuromuscular Disease and Department ofMolecular NeuroscienceInstitute of NeurologyUniversity College LondonLondonUK
GREGORY Y. H. LIP
Hemostasis, Thrombosis and Vascular Biology UnitUniversity Department of Medicine, City [email protected]
MARITA LIPSANEN-NYMAN
The Hospital for Children and AdolescentsUniversity of [email protected]
WALTER LISCH
Department of OphthalmologyKlinikum [email protected]
JIRI LITZMAN
Department of Clinical Immunology and AllergologyMasaryk UniversitySt. Anne’s University HospitalBrnoCzech [email protected]
CECILIA LO
Laboratory of Developmental BiologyNational Heart Lung Blood InstituteNational Institutes of HealthBethesda, [email protected]
List of Contributors liii
BRIGITTE M. LOBNIG
Department of Endocrinology, Diabetology andRheumatologyUniversity of [email protected]
HANNS LOCHMÜLLER
Institute of Human GeneticsNewcastle UniversityInternational Centre for LifeNewcastle upon [email protected]
JOHN LOGAN
Belfast City [email protected]
KATJA LOHMANN
Department of NeurologyUniversity of LuebeckLuebeckGermany
DIETMAR LOHMANN
Department of Human GeneticsUniversity [email protected]
DAVID A. LOMAS
Department of MedicineUniversity of CambridgeCambridge Institute for Medical [email protected]
MIRANDA LOMER
Department of GastroenterologyGuy’s & St Thomas’s NHS Foundation TrustLondonUK
NICOLA LONGO
Medical Genetics/PediatricsUniversity of UtahSalt Lake City, [email protected]
ANDREA LO MONACO
Sezione di ReumatologiaUniversità di FerraraFerraraItaly
DU TOIT LOOTS
Department of Nutrition School of Physiology, Nutrition andConsumers ScienceNorth-West UniversityPotchefstroomSouth [email protected]
ISCIA LOPES-CENDES
Department of Medical GeneticsUniversity of Campinas - UNICAMPCampinas, [email protected]
FRANCISCO J. LÓPEZ-SORIANO
Departament de Bioquímica i Biologia MolecularUniversitat de BarcelonaBarcelonaSpain
CARMEN LOQUAI
Department of Dermatology, Allergology and VenerologyUniversity of [email protected]
AXEL LORENTZ
Nutritional Medicine and PreventionUniversity of [email protected]
BIRGIT LORENZ
Department of Pediatric Ophthalmology, Strabismology andOphthalmogeneticsUniversity of Regensburg Medical [email protected]
RICHARD LORENZ
Department of Internal MedicineUlm [email protected]
JOHANN LORENZEN
Institute of PathologyClinic of Dortmund gGmbHDortmundGermany
ELAN D. LOUIS
Department of NeurologyGertrude H. Sergievsky CenterCollege of Physicians and SurgeonsColumbia UniversityNew York, [email protected]
liv List of Contributors
JULIA LÜBLIGHOFF
III. Medical DepartmentUniversity of LeipzigLeipzigGermany
THOMAS LÜCKE
Department of PediatricsHannover Medical [email protected]
MICHAELA LUCONI
Department of Clinical PhysiopathologyUniversity of [email protected]
ALBERT C. LUDOLPH
Department of NeurologyUniversity of [email protected]
AMEI LUDWIG
Institute for VirologyHeinrich-Heine-UniversityDuesseldorfGermanyamei.ludwig@uni-duesseldorf.de
THOMAS A. LUGER
Department of DermatologyUniversity Hospital of MuensterMuensterGermany
KATARZYNA LUKASIUK
The Nencki Institute of Experimental BiologyPolish Academy of [email protected]
JOËL LUNARDI
Laboratoire de Biochimie et Génétique MoléculaireCHU GrenobleGrenobleFrance
TORD M. LUNDGREN
Department of PeriodonticsLoma Linda UniversityLoma Linda, [email protected]
MALCOLM A. LYONS
Gastroenterology DivisionHarvard Medical SchoolBrigham and Women’s HospitalBoston, MAUSA
LUCIA K. MA
Heart Health Institute and Department of Cardiac ScienceThe University of CalgaryCalgary, ABCanada
MICHAEL L. H. MA
Trinity CollegeDublinIreland
PATRICK T. S. MA
Heart Health Institute and Department of Cardiac ScienceThe University of CalgaryCalgary, [email protected]
SIOBHAN D. MA
Royal College of SurgeonsDublinIreland
NAIM M. MAALOUF
Center for Mineral Metabolism and Clinical ResearchUniversity of Texas Southwestern Medical CenterDallas, [email protected]
SUSANNA MAC
Department of Chemistry and BiochemistryUniversity of CaliforniaSan Diego, [email protected]
JOHN F. MACGREGOR
Division of CardiologyUniversity of UtahSalt Lake City, [email protected]
JESUS MACHADO-SALAS
Comprehensive Epilepsy Program, Epilepsy Genetics/Genomics Laboratories and Epilepsy Center of ExcellenceUCLA School of Medicine and VA GLAHSLos Angeles, CAUSA
COLIN R. MACKENZIE
Institute of Medical Microbiology and Hospital HygieneUniversity Clinic DuesseldorfHeinrich-Heine-UniversityDuesseldorfGermanyColin.Mackenzie@uni-duesseldorf.de
List of Contributors lv
JAMIE MAGUIRE
Departments of Neurology and PhysiologyThe University of CaliforniaLos Angeles, CAUSA
VIKRAM K. MAHAJAN
Department of Dermatology,Venereology & LeprosyIndira Gandhi Medical [email protected]
HEIMO MAIRBÄURL
Department of Internal Medicine VIIDivision of Sports MedicineMedical University [email protected]
STEPHEN N. MAKONI
Trinity Cancer CareMinot, [email protected]
CARLOTTA MALAGOLI
Department of Public Health SciencesUniversity of Modena and Reggio EmiliaModenaItaly
MARCUS MALL
Department of Pediatric Oncology, Hematology,Immunology and PulmonologyUniversity of [email protected]
MARIO MANCINI
Andrology Unit, San Paolo HospitalUniversity of [email protected]
ROBERTO MANFREDI
Infectious Diseases“Alma Mater Studiorum” University of BolognaS. Orsola [email protected]
HENRY J. MANKIN
Department of Orthopedic SurgeryMassachusetts General HospitalBoston, [email protected]
NIRMAL S. MANN
School of MedicineUniversity of CaliforniaSacramento, [email protected]
BRIAN C. MANSFIELD
Correlogic Systems, Inc.Rockville, MDUSA
MASSIMO MANTEGAZZA
Deparment of NeurophysiopathologyIstituto Neurologico [email protected]
MARINA MARCHETTI
Laboratory for Clinical Thrombosis and HemostasisDepartment of Internal MedicineMaastricht UniversityMaastrichtThe Netherlands
BATSHEVA MARCOS
The Dermatology UnitKaplan Medical CenterRechovotIsrael
ANTHONY M. MARINAKI
Purine Research LaboratorySt. Thomas [email protected]
MARK A. MARINELLA
Department of Internal MedicineWright State University School of MedicineDayton, [email protected]
CARLA MARINI
Pediatric Neurology and Neurogenetics Unit andLaboratories Children’s Hospital A. [email protected]
FRANCESCA MARINI
Regional Center for Hereditary Endocrine TumoursDepartment of Internal MedicineUniversity of FlorenceFlorenceItaly
lvi List of Contributors
BRUNO MARINO
Pediatric Cardiology, Department of PediatricsUniversity La [email protected]
ARIE MARKEL
Department of Internal Medicine AHaemek Medical [email protected]
DANIEL MARKOVICH
School of Biomedical SciencesUniversity of QueenslandBrisbane, [email protected]
MARCO A. MARRA
Genome Sciences CentreBC Cancer AgencyVancouver, [email protected]
WALLACE F. MARSHALL
Department of Biochemistry & BiophysicsUniversity of CaliforniaSan Francisco, [email protected]
DIANNA C. MARTIN
Department of Biochemistry and Medical GeneticsUniversity of ManitobaWinnipeg, [email protected]
F. ELIZABETH MARTIN
Faculty of DentistryThe University of SydneySydney, [email protected]
IRIS E. MARTINEZ-JUAREZ
Comprehensive Epilepsy Program, Epilepsy Genetics/Genomics Laboratories and Epilepsy Center of ExcellenceUCLA School of Medicine and VA GLAHSLos Angeles, CAUSA
TOMMY MARTINSSON
Department of ClinicalSahlgrenska University HospitalGö[email protected]
WINFRIED MÄRZ
Synlab Center of Laboratory [email protected]
FRANK MASTAGLIA
Centre for Neuromuscular and Neurological DisordersUniversity of Western Australia, QEII Medical CentreNedlands, WAAustralia
VERENA MATEJAS
Institute of Human GeneticsUniversity of Erlangen-NurembergErlangenGermany
SISHIR MATHUR
Liver Billary Pancreatic CenterUniversity of Connecticut Health CenterFarmington, [email protected]
YOICHI MATSUBARA
Departments of Pediatrics and Medical GeneticsTohoku University School of [email protected]
NAOMICHI MATSUMOTO
Department of Human GeneticsYokohama City Graduate School of [email protected]
SHIRO MATSUMOTO
Department of PediatricsKumamoto University Graduate School of Medical ScienceKumamotoJapan
NILANJANA MAULIK
Molecular Cardiology and Angiogenesis LaboratoryDepartment of SurgeryUniversity of Connecticut Health CenterFarmington, [email protected]
KIRK J. MAURER
Gastroenterology DivisionHarvard Medical SchoolBrigham and Women’s HospitalBoston, MAUSA
List of Contributors lvii
MARIA ANTONIETTA MAZZEI
Department of RadiologyUniversity of [email protected]
FREDDY MBOTI
Medico-Surgical Department of GastroenterologyULB-Erasme [email protected]
TOMMIE V. MCCARTHY
Department of BiochemistryUniversity College [email protected]
F. DENNIS MCCOOL
Pulmonary Critical Care MedicineMemorial Hospital of Rhode IslandPawtucket, [email protected]
M. ELIZABETH MCCREADY
Ottawa Health Research InstituteOttawa, ONCanada
HEATHER E. MCDERMID
Department of Biological SciencesUniversity of AlbertaEdmonton, [email protected]
RITA L. MCGILL
Department of MedicineTeine Keijinkai HospitalTeine, [email protected]
JOHN A. MCGRATH
Genetic Skin Disease GroupSt John’s Institute of DermatologyGuy’s [email protected]
BERNADETTE MCGUINNESS
Belfast City HospitalBelfastUK
IAIN B. MCINNES
Division of Immunology, Infection and InflammationGlasgow Biomedical Research CentreUniversity of [email protected]
WILLIAM J. MCKENNA
Inherited Cardiovascular Disease GroupThe Heart Hospital, University College London Hospitals,NHS Trust and Institute of Cardiovascular ScienceUniversity College LondonLondonUK
VALLERIE V. MCLAUGHLIN
Pulmonary Hypertension ProgramUniversity of Michigan Health SystemAnn Arbor, MIUSA
TIM MCQUINN
Department of Cell Biology and AnatomyCardiovascular Developmental Biology CenterMedical University of South CarolinaCharleston, [email protected]
MOSAAD MEGAHED
Clinic of DermatologyHeinrich-Heine-UniversityDuesseldorfGermanyMegahed@uni-duesseldorf.de
DAVENDRA MEHTA
Division of Cardiac Electrophysiology and ArrhythmiaServiceMount Sinai Hospital and School of MedicineNew York, [email protected]
LAXMI S. MEHTA
Division of CardiologyDepartment of Internal MedicineThe Ohio State UniversityColumbus, [email protected]
HANS-MICHAEL MEINCK
Department of NeurologyUniversity of HeidelbergHeidelbergGermanyhans-michael_meinck@med.uni-heidelberg.de
ROBERT J. MEISLIN
NYU Hospital for Joint DiseasesNew York, [email protected]
lviii List of Contributors
EITAN MELAMED
Rabin Medical CenterPetach TikwaIsrael
MARIA MELARAGNO
Department of Liver Transplantation and HepatobiliarySurgeryRoyal Free HospitalHampstead, [email protected]
KIRSTAN K. MELDRUM
Department of Pediatric UrologyJames Whitcomb Riley Hospital for ChildrenIndiana University Medical CenterIndianapolis, [email protected]
DAMIAN C. MELLES
Department of Medical Microbiology and Infectious DiseasesErasmus University Medical CentreRotterdamThe [email protected]
ARTHUR MELMS
Department of General Neurologyand Hertie-Institute for Clinical Brain ResearchUniversity of [email protected]
MARTIN MEMPEL
Department of Dermatology and AllergologyTechnische Universitaet MunichMunichGermany
SULTAN AYOUB MEO
Department of PhysiologyCollege of MedicineKing Khalid University HospitalKing Saud UniversityRiyadhKingdom of Saudi Arabia
JULIAN F. B. MERCER
Centre for Cellular and Molecular BiologySchool of Life and Environmental SciencesDeakin UniversityBurwood, [email protected]
DEBORAH P. MERKE
Warren Grant Magnuson Clinical Center and The EuniceKennedy Shriver National Institute of Child Health andHuman DevelopmentNational Institutes of HealthBethesda, [email protected]
GEORG MERKER
Clinic of Gastroenterology, Hepatology and InfectiologyUniversity [email protected]
DIETER METZE
Department of DermatologyUniversity Hospital of [email protected]
CHRISTOPH MICHALSKI
Department of General SurgeryUniversity of HeidelbergHeidelbergGermany
VANNA MICHELI
Department of Molecular BiologyUniversity of [email protected]
LODEWYK J. MIENIE
School of BiochemistryNorth-West UniversityPotchefstroomSouth Africa
ROSSANA MINERI
Unit of Molecular NeurogeneticsPierfranco and Luisa Mariani Center for the Study ofChildren’s Mitochondrial DisordersIRCCS Foundation Neurological Institute “C Besta”MilanItaly
MASSIMILIANO MIRABELLA
Department of NeuroscienceCatholic [email protected]
EMINE DIBEK MISIRLIOĞLU
Department of PediatricsKırıkkale University Faculty of MedicineKırı[email protected]
List of Contributors lix
ROSALIA MISSERI
Children’s Hospital of New YorkPresbyterian HospitalWeill Cornell Medical CollegeNew York, [email protected]
LAURA E. MITCHELL
Institute of Biosciences and TechnologyTexas A&M University System Health Science CenterHouston, [email protected]
HIROSHI MITSUBUCHI
Department of PediatricsKumamoto University Graduate School of Medical ScienceKumamotoJapan
YOHEI MIYAGI
Molecular Pathology and Genetics DivisionKanagawa Cancer Center Research [email protected]
NORIKO MIYAKE
Department of Medicine (Genetics)Children’s Hospital Boston and Harvard Medical SchoolBoston, MAUSA
MAKOTO MIYARA
Department of Experimental PathologyInstitute for Frontier Medical SciencesKyoto UniversityKyotoJapan
SHUKI MIZUTANI
Department Pediatrics and Developmental BiologyGraduate School of MedicineTokyo Medical and Dental [email protected]
GORDANA MLINARIC-GALINOVIC
Department of VirologyCollaborating Centre WHO for VirologyCroatian National Institute of Public HealthZagrebCroatia
ABDULLAH F. MOBEIREEK
Pulmonary SectionDepartment of MedicineKing Faisal Specialist Hospital and Research CenterRiyadhSaudi [email protected]
DONALD M. MOCK
Department of Biochemistry and Molecular BiologyUniversity of Arkansas for Medical SciencesLittle Rock, [email protected]
ISTVAN MODY
Departments of Neurology and PhysiologyThe University of CaliforniaLos Angeles, [email protected]
JENS MOGENSEN
Department of CardiologyAarhus University [email protected]
MOOSA MOHAMMADI
Department of PharmacologyNew York University School of MedicineNew York, [email protected]
NILUFAR MOHEBBI
Institute of Physiology and Zurich Center for IntegrativeHuman PhysiologyUniversity of ZurichZurichSwitzerland
SARA MOLE
MRC Laboratory for Molecular Cell Biology and Departmentof Pediatrics & Child HealthUniversity College [email protected]
NESTOR A. MOLFINO
Otsuka Maryland Research InstituteRockville, [email protected]
INGRID MOLL
Department of Dermatology, and VenerologyUniversity Hospital [email protected]
ANNE M. MOLLOY
Department of BiochemistryTrinity College [email protected]
lx List of Contributors
MARIA JUDIT MOLNAR
Center for Molecular NeurologyDepartment of Neurology, [email protected]
JAN MONCOL
Faculty of Chemical and Food TechnologySlovak Technical [email protected]
MANUEL MONTESINOS-RONGEN
Department of NeuropathologyUniversity of [email protected]
TIMOTHY M. MOORE
Department of Internal MedicineUniversity of South Alabama College of MedicineMobile, [email protected]
NARAIN MOORJANI
Department of Cardiothoracic SurgeryJohn Radcliffe HospitalUniversity of [email protected]
DARIUS MORADPOUR
Division of Gastroenterology and HepatologyCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
HIROMU MORI
Department of Diagnostic and Interventional RadiologyOita University Faculty of MedicineOitaJapan
MICHAEL L. MORITZ
Division of NephrologyChildren’s Hospital of PittsburghPittsburgh, [email protected]
HIROYUKI MORIUCHI
Department of PediatricsNagasaki University School of MedicineNagasakiJapan
BERNICE E. MORROW
Department of Molecular GeneticsAlbert Einstein College of MedicineBronx, NYUSA
GEERT MORTIER
Center for Medical GeneticsGhent University [email protected]
KATHRYN MOSELEY
CHEARUniversity of Michigan Medical SchoolAnn Arbor, [email protected]
S. HARVEY MUDD
NIHM/DIRP/LMBNational Institutes of HealthBethesda, [email protected]
WALTER MUIR
Division of PsychiatrySchool of Molecular and Clinical MedicineUniversity of EdinburghRoyal Edinburgh HospitalEdinburghUK
ROGER MULDER
Department of Psychological MedicineChristchurch School of Medicine and Health SciencesUniversity of OtagoChristchurchNew Zealand
NORBERT MÜLLER
Hospital for Psychiatry and PsychotherapyLudwig-Maximilians-UniversityMunichGermanynorbert.mueller@med.uni-muenchen.de
ULRICH MÜLLER
Institute of Human GeneticsGiessen UniversityGiessenGermanyUlrich.Mueller@humangenetik.med.uni-giessen.de
STEVEN MUMM
Division of Bone and Mineral DiseasesWashington University School of MedicineSt. Louis, [email protected]
List of Contributors lxi
EGBERT MUNDT
Department of Population HealthUniversity of GeorgiaAthens, [email protected]
MARCO MURA
Malattie RespiratoriePoliclinico Tor [email protected]
FERID MURAD
Department of Integrative Biology and PharmacologyThe Medical SchoolUniversity Of Texas Health Sciences CenterHouston, [email protected]
PATRICK MURRAY
University of ChicagoChicago, [email protected]
GIOVANNA MUSCO
Dulbecco Telethon Institute, Biomolecular NMR Laboratoryc/o DIBIT S.Raffaele Scientific [email protected]
BENNETT MYERS
Dent Neurological InstituteOrchard Park, [email protected]
RIMA NABBOUT
Department of Pediatric NeurologyHôpital Necker Enfants [email protected]
MANGALA A. NADKARNI
Institute of Dental Research, Westmead Millennium Instituteand Westmead Centre for Oral HealthWestmead HospitalWestmead, [email protected]
MIKI NAGASE
Department of Nephrology and EndocrinologyUniversity of Tokyo Graduate School of [email protected]
YOJI NAGASHIMA
Department of Molecular PathologyYokohama City University Graduate School of [email protected]
YASUAKI NAKAGAWA
Department of Orthopedic SurgeryFaculty of MedicineKyoto [email protected]
KIMITOSHI NAKAMURA
Department of PediatricsKumamoto University Graduate School of Medical [email protected]
M. MURAT NAKI
Department of Obstetrics and GynecologyGöztepe Research and Education [email protected]
MALLIKARJUNA NALLEGOWDA
Department of Physical Medicine and RehabilitationAll India Institute of Medical SciencesNew [email protected]
JAE-HWAN NAM
Laboratory of Viral ImmunologyDepartment of BiotechnologyThe Catholic University of KoreaBucheon, [email protected]
THOMAS NAMDAR
Department of General, Visceral and Pediatric SurgeryUniversity Hospital DuesseldorfHeinrich-Heine [email protected]
MASAOMI NANGAKU
Division of Nephrology and EndocrinologyUniversity of Tokyo School of [email protected]
CARLO PACE NAPOLEONE
Pediatric Cardiac Surgery UnitS. Orsola-Malpighi HospitalBolognaItaly
lxii List of Contributors
DOROTHEE NASHAN
Department of DermatologyUniversity of FreiburgFreiburgGermany
SIRAJEDIN NATAH
Gastrointestinal Research GroupDepartment of Physiology & BiophysicsThe University of CalgaryCalgary, [email protected]
YESIM NEGIS
Vascular Biology LaboratoryJM USDA-HNRCATufts University BostonBoston, MSUSA
BERND A. NEUBAUER
Department of Pediatric NeurologyChildren’s Medical CenterUniversity of Giessen and [email protected]
JOHN NEWSOM-DAVIS*Weatherall Institute of Molecular Medicine, John RadcliffeHospital, Department of Clinical NeurologyUniversity of [email protected]
TAM NGUYEN
University of [email protected]
SOPHIE NICOLE
InsermUniversité Pierre et Marie [email protected]
FRANCK E. NICOLINI
Hematology DepatmentEdouard Herriot [email protected]
CHRISTOPHE NICOT
Department of Microbiology, Immunology and MolecularGeneticsUniversity of Kansas Medical CenterKansas City, [email protected]
HANS HELMUT NILLER
Institute of Medical MicrobiologyUniversity of RegensburgRegensburgGermany
INGO NINDL
Applied TumorvirologyGerman Cancer Research Center (DKFZ)[email protected]
TOSHIO NISHIKIMI
Department of Hypertension and Cardiorenal MedicineDokkyo Medical UniversityMibu, [email protected]
KOICHIRO NIWA
Department of PediatricsChiba Cardiovascular [email protected]
SOHEYL NOACHTAR
Section of SleepDepartment of NeurologyUniversity of [email protected]
DONATUS NOHR
Department of Biological Chemistry and NutritionUniversity [email protected]
CHARLES R. NOLAN
Department of Medicine & SurgeryUniversity of Texas Health Sciences CenterSan Antonio, [email protected]
JOHANNES C. NOSSENT
Department of RheumatologyInstitute Clinical MedicineUniversity of Tromsø and University Hospital North NorwayTromsø[email protected]* deceased
List of Contributors lxiii
MARKUS M. NÖTHEN
Department of Genomics, Life and Brain CenterUniversity of [email protected]
CARLO NUNES
Department of GastroenterologyGuy’s & St Thomas’s NHS Foundation TrustLondonUK
JEAN-MARC NUOFFER
Institute of Clinical ChemistryInselspitalBern University Hospital and University of [email protected]
WILLIAM L. NYHAN
Department of PediatricsUniversity of California at San DiegoLa Jolla, [email protected]
ABRAHAM NYSKA
Sackler School of MedicineTel Aviv UniversityTel [email protected]
JOHANN OCKENGA
Department of Gastroenterology,Hepatology and EndocrinologyCharité University [email protected]
MARK OETTE
Clinic for Gastroenterology, Hepatology, and InfectiousDiseasesUniversity Clinic [email protected]
GOO TAEG OH
Laboratory of Cardiovascular GenomicsEwha Womans [email protected]
VINZENZ OJI
Department of DermatologyUniversity Hospital of [email protected]
FUMITO OKADA
Department of Diagnostic and Interventional RadiologyOita University Faculty of [email protected]
LAJOS OKOLICSANYI
Gastroenterology Unit, Liver Transplantation UnitDepartment of Surgical and Gastroenterological SciencesUniversity Hospital of PaduaPaduaItaly
ANDERS OLDFORS
Department of PathologySahlgrenska University HospitalGö[email protected]
ALEXANDER OLIVARES-REYES
Guerriari Heart & Cardiovascular InstitutePenisula Regional Medical CenterSalisbury, [email protected]
DARIO OLIVIERI
Department of Clinical SciencesRespiratory Disease SectionUniversity of ParmaParmaItaly
BOB OLSSON
Hematology Section, Department of Internal MedicineSahlgrenska University [email protected]
ANDO ASAMI ONO
Department of Diagnostic and Interventional RadiologyOita University Faculty of MedicineOitaJapan
GUIDO OPPIDO
Pediatric Cardiac Surgery UnitS. Orsola-Malpighi [email protected]
JORDAN S. ORANGE
Children’s Hospital of PhiladelphiaPhiladelphia, [email protected]
lxiv List of Contributors
EDITH ORION
The Dermatology UnitKaplan Medical CenterRechovotIsrael
LEONARD O’SULLIVAN
Ergonomics Research GroupManufacturing and Operations Engineering DepartmentUniversity of [email protected]
CHRISTY T. OSWALT
Division of EndocrinologyUniversity of Mississippi Medical CenterJackson, MSUSA
PAUL A. OVERBEEK
Department of Molecular and Cellular BiologyBaylor College of MedicineHouston, [email protected]
INGRID PABINGER
Division of Hematology and HemostaseologyDepartment of Internal Medicine IMedical University [email protected]
KAREL PACAK
Clinical Neurocardiology SectionNINDS, National Institutes of HealthBethesda, MDUSA
GEORGE W. PADBERG
Department of NeurologyRadboud University Nijmegen Medical CentreNijmegenThe [email protected]
RODOLFO PAOLETTI
Department of Pharmacological SciencesUniversity of [email protected]
JAMES J. PAPARELLO
Division of Nephrology and HypertensionNorthwestern University Medical SchoolChicago, [email protected]
ELENA PARRINI
Pediatric Neurology and Neurogenetics Unit and LaboratoriesChildren’s Hospital A. [email protected]
RALF PASCHKE
Department of Internal Medicine IIIUniversity of [email protected]
MARZIA PASQUALI
Department of Pathology and ARUP Institute for Clinical andExperimental PathologySalt Lake City, [email protected]
MARIA RITA PASSOS-BUENO
Human Genome Research CenterDepartment of Genetics and Evolutionary BiologyInstitute of BiosciencesUniversity of São PauloSão [email protected]
LEV I. PATRUSHEV
Department of BiotechnologyShemyakin-Ovchinnikov Institute of Bioorganic [email protected]
DANIEL F. PAULY
Department of Medicine, Division of CardiovascularMedicineUniversity of FloridaGainesville, [email protected]
RALF PAUS
Department of Dermatology, Venerology and AllergyUniversity Hospital Schleswig-HolsteinUniversity of [email protected]
PIERO PAVONE
Department of PediatricsUniversity of [email protected]
List of Contributors lxv
SIMON H. PEARCE
Institute of Human GeneticsInternational Centre for LifeUniversity of Newcastle upon TyneNewcastle upon [email protected]
JEAN-FRANÇOIS PELLISSIER
Laboratoire de Biopathologie Nerveuse et MusculaireFaculté de Médecine de MarseilleMarseilleFrancejean-francois.pellissier@medecine.univ-mrs.fr
KATERINA TANYA B. PEREZ-GOSIENGFIAO
Comprehensive Epilepsy Program, Epilepsy Genetics/Genomics Laboratories and Epilepsy Center of ExcellenceUCLA School of Medicine and VA GLAHSLos Angeles, CAUSA
NILS PETERS
Department of NeurologyLudwig-Maximilians-University [email protected]
ROLAND PFÄFFLE
Pediatric DepartmentUniversity of LeipzigLeipzigGermany
KLAUS PFEFFER
Institute of Medical Microbiology and Hospital HygieneUniversity Clinic DuesseldorfHeinrich-Heine-UniversityDuesseldorfGermanyKlaus.Pfeffer@uni-duesseldorf.de
HANS-WALTER PFISTER
Department of NeurologyLudwig-Maximilians [email protected]
MARKUS PFISTER
Department of Otolaryngology and Head and Neck SurgeryUniversity of [email protected]
STEFAN PFISTER
Department of Pediatric Oncology, Hematology andImmunologyUniversity of [email protected]
FABIENNE PICARD
Department of NeurologyUniversity Hospital of [email protected]
BEN PICKARD
Medical Genetics Section, Molecular Medicine CentreUniversity of EdinburghWestern General [email protected]
CHIARA PIERANTONI
Clinica di Oncologia Medica, Università Politecnica delleMarcheOspedali Riuniti Umberto I –GMLancisi –GSalesi diAnconaAnconaItaly
MASSIMO PINZANI
Dipartimento di Medicina InternaUniversità degli Studi di [email protected]
ELENA PIOVESANA
Gastroenterology Unit, Liver Transplantatioin Unit,Department of Surgical and Gastroenterological SciencesUniversity Hospital of PaduaPaduaItaly
ELENA PISCHIK
Porphyria Research CentreBiomedicum-HelsinkiUniversity of [email protected]
ASLA PITKÄNEN
Department of NeurobiologyA.I.Virtanen Institute for Molecular SciencesUniversity of [email protected]
CLAUDIU PLESA
Hematology DepartmentEdouard Herriot [email protected]
STEFAN K. PLONTKE
Department of Otorhinolaryngology – Head and NeckSurgeryUniversity of [email protected]
lxvi List of Contributors
T. BALAKRISHNA PODUVAL
Immunology and Hyperthermia SectionRadiation Biology and Health Sciences DivisionBhabha Atomic Research [email protected]
DON POLDERMANS
ThoraxcenterDepartment of CardiologyErasmus Medical Center RotterdamRotterdamThe [email protected]
BWEE TIEN POLL-THE
Department of Pediatric NeurologyEmma Children’s HospitalAcademic Medical CenterAmsterdamThe [email protected]
ZORAN V. POPOVIC
Department of Cellular and Molecular PathologyGerman Cancer Research CenterUniversity of [email protected]
JAMES M. POWERS
Department of Pathology, School of Medicine and DentistryUniversity of RochesterRochester, [email protected]
CHRISTIAN POX
Medical DepartmentRuhr-University [email protected]
AINU PRAKASH-CHENG*Department of Genetics and Genomic SciencesMount Sinai School of Medicine of New York UniversityNew York, [email protected]
HILMAR PRANGE
Department of NeurologyGeorg-August-University [email protected]
ANANDA S. PRASAD
Department of Medicine, Division of Hematology-OncologyWayne State UniversityUniversity Health CenterDetroit, [email protected]
MARKUS N. PREISING
Department of Pediatric Ophthalmology, Strabismology andOphthalmogeneticsUniversity of Regensburg Medical [email protected]
NOEL W. PRESTON
Microbial ImmunologyUniversity of [email protected]
DOMINIQUE PRIÉ
INSERMUniversity of [email protected]
LOURDES PRIETO
Department of Congenital Heart DiseaseCleveland Clinic FoundationCleveland, [email protected]
SILVIA G. PRIORI
Molecular CardiologyIRCCS Fondazione [email protected]
PETER PROPPING
Institute of Human GeneticsUniversity of [email protected]
TREVOR J. PUGH
Genome Sciences CentreBC Cancer AgencyVancouver, BCCanada
HERVÉ PUY
Centre Français des PorphyriesINSERMHôpital Louis [email protected]* deceased
List of Contributors lxvii
ROSALINE C. M. QUINLIVAN
Centre for Inherited Neuromuscular DisordersRobert Jones and Agnes Hunt Orthopaedic and DistrictHospital NHS [email protected]
JULIE RAGGIO
Department of MedicineGeorgetown UniversityWashington, DCUSA
OLAYINKA RAHEEM
Neuromuscular PathologyUniversity of [email protected]
SATISH R. RAJ
Vanderbilt UniversityMedical Center NorthNashville, TNUSA
SINGH RAJENDER
Centre for Cellular and Molecular BiologyHyderabadIndia
NANDHAGOPAL RAMACHANDIRAN
Pacific Parkinson’s Research CentreVancouver, [email protected]
HENA R. RAMAY
Pharmacology and Systems TherapeuticsMount Sinai School of MedicineNew York, NYUSA
YUVAL RAMOT
Hadassah – Hebrew University Medical [email protected]
TROY D. RANDALL
Trudeau InstituteSaranac Lake, [email protected]
JAVIER RANGEL-MORENO
Trudeau InstituteSaranac Lake, NYUSA
P. SYAMASUNDAR RAO
Division of Pediatric CardiologyThe University of Texas/Houston Medical SchoolChildren’s Memorial Hermann HospitalHouston, [email protected]
GUDRUN RAPPOLD
Institute of Human GeneticsUniversity of [email protected]
CARLA RAUTENBERG
Division of Rheumatology and Clinical ImmunologyUniversity Hospital [email protected]
ROBERTO RAVAZZOLO
Laboratory of Molecular GeneticsG. Gaslini InstituteDepartment of PediatricsUniversity of [email protected]
AMY S. RAWLS
Division of OncologyDepartment of MedicineWashington UniversitySt. Louis, MOUSA
DOMINIQUE RÉCAN-BUDIARTHA
Laboratoire de Biochimie et Génétique MoléculaireHôpital Cochin [email protected]
MIKE RECHER
Clinic for ImmunologyDepartment of Internal MedicineUniversity Hospital [email protected]
HARI REDDY
Division of CardiologyVeterans Affairs Greater Los Angeles Healthcare System andThe David Geffen School of Medicine at UCLALos Angeles, CAUSA
RICHARD J. REECE
Faculty of Life SciencesUniversity of ManchesterManchesterUK
lxviii List of Contributors
DAVID C. REES
King’s College [email protected]
GUIDO REIFENBERGER
Department of NeuropathologyHeinrich-Heine-UniversityDuesseldorfGermanyreifenberger@med.uni-duesseldorf.de
ROLAND REINEHR
Clinic for Gastroenterology, Hepatology and InfectiologyUniversity Hospital [email protected]
ANDRÉ REIS
Institute of Human GeneticsUniversity of [email protected]
JAN RÉMI
Section of SleepDepartment of NeurologyUniversity of [email protected]
BETTINA C. REULECKE
Department of PediatricsUniversity Hospital of [email protected]
ARNOLD REUSER
Department of Clinical GeneticsErasmus Medical CenterRotterdamThe [email protected]
STEFAN REUTER
Clinic for Gastroenterology, Hepatology and InfectiologyHeinrich-Heine-UniversityDuesseldorfGermanyStefan.Reuter@med.uni-duesseldorf.de
NICOLE REVENCU
Laboratory of Human Molecular GeneticsChristian de Duve Institute of Cellular PathologyUniversité Catholique de [email protected]
JOACHIM RICHTER
Tropical Medicine UnitClinics for Gastroenterology, Hepatology andInfectious DiseasesHeinrich-Heine-UniversityDuesseldorfGermanyJoachim.Richter@med.uni-duesseldorf.de
ANNETTE RICHTER-UNRUH
Endokrinologikum [email protected]
MARKUS J. RIEMENSCHNEIDER
Department of NeuropathologyHeinrich-Heine-UniversityDuesseldorfGermanyM.J.Riemenschneider@gmx.de
FELIX G. RIEPE
Division of Pediatric Endocrinology and DiabetesDepartment of PediatricsUniversity Hospital Schleswig-HolsteinChristian-Albrechts-UniversityKielGermanyfriepe@pediatrics.uni-kiel.de
MARCELLA RIETSCHEL
Department of GenomicsUniversity of BonnBonnGermany
MARC RIGHINI
Angiology and HemostasisUniversity Hospitals of GenevaGenevaSwitzerland
EVA RIVEIRA-MUNOZ
Division of NephrologyUCL Medical SchoolBrusselsBelgium
AVRAHAM I. RIVKIND
Department of SurgeryHadassah University [email protected]
KURT C. ROBERTS-THOMSON
Department of CardiologyRoyal Melbourne HospitalUniversity of MelbourneMelbourne, [email protected]
List of Contributors lxix
DAVID ROBERTSON
Autonomic Dysfunction CenterVanderbilt UniversityNashville, [email protected]
DROR ROBINSON
Rabin Medical CenterPetach [email protected]
WIILIAM LANE M. ROBSON
The Childrens’ ClinicCalgary, [email protected]
VINCENZO ROCHIRA
Department of Medicine, Endocrinology & MetabolismGeriatricsUniversity of Modena and Reggio [email protected]
H. PETER RODEMANN
Division of Radiobiology & Molecular EnvironmentalResearchDepartment of Radiation OncologyEberhard-Karls [email protected]
DAN M. RODEN
Vanderbilt University School of MedicineNashville, [email protected]
CHAIM M. ROIFMAN
Division of Immunology and AllergyThe Hospital for Sick ChildrenToronto, [email protected]
JESSE ROMAN
Department of MedicineEmory University School of MedicineAtlanta, [email protected]
PIERRE RONCO
INSERM, [email protected]
ANGELIQUE L. ROPS
Nephrology Research LaboratoryNijmegen Centre for Molecular Life SciencesDivision of NephrologyRadboud University Nijmegen Medical CentreNijmegenThe [email protected]
TOM ROSSENBACKER
Molecular CardiologyIRCCS Fondazione MaugeriPaviaItaly
BERNARD C. ROSSIER
Department of Pharmacology and ToxicologyLausanne UniversityLausanneSwitzerland
ELIO ROTI
Istituto di EndocrinologiaUniversity of [email protected]
MARTIN ROTTER
Swiss Cardiovascular Center BernUniversity [email protected]
ANDREW ROZELLE
Division of Immunology and RheumatologyStanford University School of MedicinePalo Alto, CAUSA
TODD D. ROZEN
Michigan Head-Pain and Neurological InstituteAnn Arbor, [email protected]
JAN ROZING
Department of Cell Biology, Immunology SectionUniversity Medical Center GroningenGroningenThe [email protected]
LEWIS J. RUBIN
Division of Pulmonary and Critical Care MedicineDepartment of MedicineUniversity of California at San DiegoLa Jolla, CAUSA
lxx List of Contributors
SABINE RUDNIK-SCHÖNEBORN
Institute of Human GeneticsAachen University of [email protected]
GUENTER RUDOLPH
Eye ClinicLudwig-Maximilians-University MunichMunichGermany
ISABELLE L. RUEL
Institute on Nutraceuticals and Functional FoodsLaval UniversityQuébec, QCCanada
KLAUS RUETHER
Department of Ophtalmology, CVKCharité[email protected]
ROBERT RUFFOLO
Research and DevelopmentWyeth ResearchCollegeville, [email protected]
RAINER RUPPRECHT
Department of PsychiatryLudwig-Maximilian-University [email protected]
TOBIAS A. RUPPRECHT
Department of NeurologyLudwig-Maximilians-UniversityMunichGermanyTobias.Rupprecht@med.uni-muenchen.de
RICHARD L. SABINA
Medical College of WisconsinMilwaukee, [email protected]
MARCUS D. SÄEMANN
Department of Internal Medicine IIIDivision of Nephrology and DialysisMedical University of [email protected]
SEZER SAGLAM
Department of Medical OncologyOncology InstituteIstanbul [email protected]
GIUSEPPE SAGLIO
Department of Clinical and Biological SciencesUniversity of TurinS.Luigi [email protected]
AMRIK SAHOTA
Nelson Laboratory, Department of GeneticsRutgers UniversityPiscataway, [email protected]
HARJOT K. SAINI
St. Boniface General Hospital Research CentreUniversity of ManitobaWinnipeg, MBCanada
SHIMON SAKAGUCHI
Department of Experimental PathologyInstitute for Frontier Medical SciencesKyoto [email protected]
KHASHAYAR SAKHAEE
Center for Mineral Metabolism and Clinical ResearchUniversity of Texas Southwestern Medical CenterDallas, [email protected]
JORGE I. SALLUH
National Cancer InstituteRio de [email protected]
RÉMI SALOMON
Service de Néphrologie PédiatriqueHôpital Necker-Enfants MaladesParisFrance
ULRICH SALZER
Department of Medicine, Division of Rheumatology andClinical ImmunologyUniversity Hospital [email protected]
List of Contributors lxxi
MILLIE SAMANIEGO
University of Wisconsin School of Medicine and PublicHealthMadison, [email protected]
DIMITRIOS SAMONAKIS
Department of Liver Transplantation and HepatobiliarySurgeryRoyal Free HospitalHampstead, LondonUK
SEDA SANCAK
Marmara University Medical [email protected]
JEREMY SANDERSON
Department of GastroenterologyGuy’s & St Thomas’s NHS Foundation TrustLondonUK
KONRAD SANDHOFF
LIMES Program Unit Membrane Biology and LipidBiochemistryKekulé InstituteBonn [email protected]
ANNA SARKOZY
Department of Experimental MedicineUniversity La Sapienza and CSS-Mendel [email protected]
NICHOLAS J. SARLIS
Department of Medical AffairsOncologyU.S. Pharma OpsSanofi-AventisBridgewater, [email protected]
HIROKAZU SASAKI
Department of Emergency and Critical Care MedicineTokyo Medical UniversityShinjuku, [email protected]
JEAN MARIE SAUDUBRAY
Hôpital Necker [email protected]
TILMAN SAUERBRUCH
Department of Internal Medicine IUniversity of [email protected]
REGINALD S. SAUVE
Department of PediatricsAlberta Children’s HospitalThe University of CalgaryCalgary, ABCanada
MARTIN O. SAVAGE
Pediatric Endocrinology SectionDepartment of EndocrinologySt. Bartholomew’s HospitalLondonUK
RAVI SAVARIRAYAN
Genetic Health Services VictoriaMurdoch Children’s Research Institute and Department ofPediatricsUniversity of MelbourneMelbourne, VICAustralia
ANDREW J. SAXON
University of Washington School of Medicine and VeteransAffairs Puget Sound Health Care SystemSeattle, [email protected]
JOHN A. SAYER
Institute of Human GeneticsInternational Centre for LifeUniversity of Newcastle upon TyneNewcastle upon [email protected]
ANDROMACHI SCARADAVOU
Laboratory of Complement BiologyNew York Blood CenterNew York, [email protected]
MARIO SCARTOZZI
Clinica di Oncologia MedicaUniversità Politecnica delle MarcheOspedali Riuniti Umberto I – GM Lancisi – G Salesi diAnconaAnconaItaly
FRANK SCHAEFFEL
Section Neurobiology of the EyeUniversity Eye [email protected]
lxxii List of Contributors
JULIE V. SCHAFFER
Department of DermatologyNew York University School of MedicineNew York, [email protected]
KARIN SCHARFFETTER-KOCHANEK
Department of Dermatology and AllergologyUniversity of [email protected]
HUBERT SCHARNAGL
Clinical Institute of Medical and Chemical LaboratoryDiagnosticsMedical University of [email protected]
INGRID E. SCHEFFER
Department of Medicine and PediatricsUniversity of MelbourneMelbourne, VICAustralia
UTE SCHEPERS
LIMES Institute Program Unit Membrane Biology & LipidBiochemistryKekulé-InstituteUniversity BonnBonnGermany
LAURENT SCHILD
Department of Pharmacology and ToxicologyLausanne [email protected]
OLIVER SCHILDGEN
Department of VirologyInstitute for Medical Microbiology, Immunology, [email protected]
MEINHARD SCHILLER
Department of DermatologyUniversity [email protected]
MARTIN SCHILLINGER
Department of Internal Medicine II, Division of AngiologyUniversity of Vienna, Medical [email protected]
WOLFGANG SCHILLINGER
Heart CenterUniversity [email protected]
SIMONE SCHIMPF
Molecular Genetics LaboratoryInstitute for Ophthalmic ResearchCentre for OphthalmologyUniversity of [email protected]
AREND F. L. SCHINKEL
Thoraxcenter, Department of CardiologyErasmus Medical Center RotterdamRotterdamThe [email protected]
SVEN SCHINNER
Department of Endocrinology, Diabetes and RheumatologyUniversity Hospital DuesseldorfDuesseldorfGermany
ALBERT SCHINZEL
Institute of Medical GeneticsUniversity of [email protected]
ERWIN SCHLEICHER
Department of Internal MedicineDivision of Endocrinology, Angiology, Nephrology andClinical ChemistryUniversity Hospital TuebingenTuebingenGermany
FREIMUT SCHLIESS
Department of Gastroenterology, Hepatology andInfectiologyUniversity-HospitalHeinrich-Heine-UniversityDuesseldorfGermanyFreimut.Schliess@uni-duesseldorf.de
BERNHARD SCHMIDT
Department of BiochemistryGeorg-August-University GoettingenGoettingenGermany
HARTMUT SCHMIDT
University Hospital of [email protected]
List of Contributors lxxiii
WOLFF SCHMIEGEL
Medical DepartmentRuhr-University [email protected]
MARCUS SCHMITT
Clinic for Gastroenterology, Hepatology and InfectiologyHeinrich-Heine-UniversityDuesseldorfGermanyMarcus.Schmitt@uni-duesseldorf.de
STEFFEN SCHMITZ-VALCKENBERG
Institute of Ophthalmology and Moorfields Eye HospitalLondonUK
SUSANNE A. SCHNEIDER
Sobell Department of Motor Neuroscience and MovementDisordersInstitute of [email protected]
SUSANNE SCHNITTGER
Munich Leukemia Laboratory (MLL)MunichGermany
JOHN-JOHN B. SCHNOG
Department of Internal MedicineSlotervaart HospitalAmsterdamThe [email protected]
HENDRIK P. N. SCHOLL
Department of OphthalmologyUniversity of [email protected]
JÜRGEN SCHÖLMERICH
Department of Internal Medicine IUniversity Medical Center RegensburgRegensburgGermanyjuergen.schoelmerich@klinik.uni-regensburg.de
LUDGER SCHÖLS
Department for Neurodegenerative DiseasesHertie-Institute for Clinical Brain Research and Centre [email protected]
GUSTAV SCHONFELD
Washington University in St. Louis School of MedicineSt. Louis, [email protected]
BENEDIKT G. H. SCHOSER
Department of NeurologyFriedrich-Baur-InstituteLudwig-Maximilians University [email protected]
RUTH SCHREIBER
Department of PediatricsSoroka University Medical CenterBeer ShevaIsrael
JOHANN MICHAEL SCHRÖDER
RWTH Aachen University [email protected]
ROLF SCHRÖDER
Department of NeurologyUniversity of [email protected]
EDWARD H. SCHUCHMAN
Department of Genetics and Genomic SciencesMount Sinai School of Medicine of New York UniversityNew York, NYUSA
REBECCA SCHÜLE
Department for Neurodegenerative DiseasesHertie-Institute for Clinical Brain Research and Centre forNeurologyTuebingenGermanyrebecca.schuele-freyer@med.uni-tuebingen.de
ULRICH S. SCHULER
Medical Clinic IUniversity Hospital [email protected]
KARSTEN SCHULMANN
Medical DepartmentRuhr-University [email protected]
lxxiv List of Contributors
JAN SCHULTE AM ESCH
Department of General-, Visceral- and Pediatric SurgeryUniversity Hospital DuesseldorfHeinrich-Heine-UniversityDuesseldorfGermanyjan.schulteamesch@med.uni-duesseldorf.de
ANSGAR SCHULZ
University Children’s HospitalUniversity of UlmUlmGermany
HEIKE SCHULZE
LIMES Program Unit Membrane Biology and LipidBiochemistryKekulé InstituteBonn UniversityBonnGermany
JÖRG-DIETER SCHULZKE
Gastroenterology and InfectiologyCampus Benjamin FranklinCharité[email protected]
JOHANNES SCHUMACHER
Institute of Human GeneticsUniversity of [email protected]
ULRIKE SCHUMACHER
Institute of Medical Microbiology and HygieneUniversity of TuebingenTuebingenGermany
KLAUS SCHÜMANN
Technical University [email protected]
DETLEF SCHUPPAN
Division of Gastroenterology and HepatologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBoston, [email protected]
ANDREA SCHUPPENIES
Medical Clinic IIIUniversity Hospital [email protected]
BÄRBEL SCHÜTTE
Department of DermatologyUniversity of [email protected]
GESA SCHWANITZ
Institute of Human GeneticsUniversity of [email protected]
ELISABETH L. SCHWARZ
Department of Pathology and ARUP Institute for Clinical andExperimental PathologySalt Lake City, [email protected]
JOHANNES SCHWARZ
Department of NeurologyUniversity of LeipzigLeipzigGermany
MARTIN SCHWARZ
Department of Gastroenterology, Hepatology andInfectiologyUniversity-HospitalHeinrich-Heine-UniversityDuesseldorfGermany
PETER E. H. SCHWARZ
Technical University DresdenMedical Clinic [email protected]
THOMAS SCHWARZ
Department of DermatologyUniversity Hospital of Schleswig-HolsteinCampus [email protected]
FRITZ SCHWARZMANN
Institute of Medical MicrobiologyUniversity of RegensburgRegensburgGermany
NORBERT SCHWENZER
Department of Oral and Maxillofacial SurgeryEberhard-Karls-UniversityTuebingenGermany
List of Contributors lxxv
HEINRICH SCHWINDT
Department of NeuropathologyUniversity of CologneCologneGermany
FRANCESCA SCIANDRA
CNR, Istituto di Chimica del Riconoscimento Molecolarec/o Istituto di Biochimica e Biochimica ClinicaUniversità Cattolica del Sacro [email protected]
C. RONALD SCOTT
Division of Medical GeneticsUniversity of WashingtonSeattle, [email protected]
JOHN M. SCOTT
Department of BiochemistryTrinity College [email protected]
WENDY M. SEALEY
Department of Biochemistry and Molecular BiologyUniversity of Arkansas for Medical SciencesLittle Rock, ARUSA
JENO SEBES
Saravanan Kasthury University of Tennessee Medical CenterMemphis, [email protected]
RONNEN H. SEGMAN
Department of PsychiatryHadassah University [email protected]
JENS SEILER
Swiss Cardiovascular Center BernUniversity [email protected]
BERTHOLD SEITZ
Department of OphthalmologyUniversity of SaarlandHomburg/[email protected]
ANGELO SELICORNI
Department of Pediatrics, Hematology, Oncology andEndocrinologyMedical University of [email protected]
CARLO SELMI
Division of Rheumatology, Allergy and Clinical ImmunologyUniversity of California at DavisDavis, CAUSA
JOSEPH B. SELVANAYAGAM
Department of Cardiovascular MedicineFlinders Medical CentreBedford Park, [email protected]
ATILLA ŞENAYLI
Department of Pediatric SurgeryGaziosmanpaşa University School of MedicineTokatTurkey
SRIJITA SEN-CHOWDHRY
Inherited Cardiovascular Disease GroupThe Heart HospitalUniversity College London HospitalsNHS Trust and Institute of Cardiovascular ScienceUniversity College [email protected]
MARCO SENZOLO
Gastroenterology Unit, Liver Transplantation Unit,Department of Surgical and Gastroenterological SciencesUniversity Hospital of [email protected]
JOSE M. SERRATOSA
Department of NeurologyFundación Jiménez Díaz and Universidad Autónoma [email protected]
GEORGES SERRATRICE
Service de Neurologie et Maladies [email protected]
lxxvi List of Contributors
CAROLINE A. SEWRY
Centre for Inherited Neuromuscular DisordersRobert Jones and Agnes Hunt Orthopedic and DistrictHospital NHS [email protected]
MUAMMER SEYHAN
Department of DermatologyInonu [email protected]
ENGIN SEZER
Department of DermatologyGaziosmanpaşa University School of [email protected]
ARTI N SHAH
Division of Cardiac ElectrophysiologyMount Sinai School of MedicineElmhurst Hospital CenterElmhurst, NYUSA
ARIEH Y. SHALEV
Department of PsychiatryHadassah University [email protected]
HUI SHAO
Department of Ophthalmology and Visual SciencesUniversity of LouisvilleLouisville, KYUSA
NAND LAL SHARMA
Department of DermatologyVenereology & Leprosy Indira Gandhi Medical [email protected]
SUMEET K. SHARMA
The University of Texas/Houston Medical SchoolChildren’s Memorial Hermann HospitalHouston, [email protected]
YOGESH M. SHASTRI
Department of Medicine IZAFESJ. W. Goethe-University [email protected]
ROBERT S. SHELDON
Libin Cardiovascular Institute of AlbertaThe University of CalgaryCalgary, ABCanada
WATARU SHIMIZU
Division of Cardiology, Department of Internal MedicineNational Cardiovascular CenterSuita, [email protected]
OSAMU SHIMOKAWA
Kyusyu Medical Science Nagasaki LaboratoryNagasakiJapan
YOON S. SHIN
Children’s HospitalUniversity of [email protected]
TAKAHIRO SHINKAI
Department of PsychiatryUniversity of Occupational and Environmental [email protected]
HARUO SHINTAKU
Department of PediatricsOsaka City University Graduate School of [email protected]
MASAAKI SHIOHARA
Department of PediatricsShinshu University, School of [email protected]
ANUSHREE C. SHIRALI
Department of Internal MedicineSection of NephrologyYale University School of MedicineNew Haven, [email protected]
VORASUK SHOTELERSUK
Division of Medical Genetics and MetabolismDepartment of PediatricsChulalongkorn [email protected]
List of Contributors lxxvii
WEINIAN SHOU
Department of Pediatrics, Biochemistry and MolecularBiologyIndiana University School of MedicineHerman B Wells Center for Pediatric ResearchIndianapolis, [email protected]
KENNETH R. SHROYER
Departments of Dermatology and PathologyUniversity of Colorado School of MedicineDenver, COUSA
ERIC SIBLEY
Division of Pediatric GastroenterologyStanford University School of MedicineStanford, [email protected]
REINER SIEBERT
Institute of Human GeneticsUniversity Hospital Schleswig-HolsteinCampus [email protected]
SÖREN V. SIEGMUND
Department of Medicine II (Gastroenterology, Hepatologyand Infectious Diseases)University Hospital of [email protected]
ROSWITHA SIENER
Department of UrologyUniversity of [email protected]
MATTHIAS SIEPE
Department of Cardiovascular SurgeryUniversity Medical Center [email protected]
CAROLINE SILVE
INSERMUniversity of [email protected]
GABRIELLA SILVESTRI
Department of NeuroscienceCatholic [email protected]
H. ANNE SIMMONDS
Purine Research UnitGuy’s HospitalKing’s [email protected]
CHRISTIAN SIMON
Department of Otolaryngology–Head and Neck SurgeryRuprecht-Karls-UniversityHeidelbergGermanycsimon1407@aol.com
JANA ŠÍMOVÁ
Department of Tumour ImmunologyInstitute of Molecular GeneticsAcademy of Sciences of the Czech RepublicPragueCzech [email protected]
JOHN SIMPSON
Department of General SurgeryUniversity [email protected]
ANCA SINDRILARU
Department of DermatologyUniversity of MuensterMuensterGermany
MANFRED V. SINGER
Department of Medicine II (Gastroenterology, Hepatologyand Infectious Diseases)University Hospital of [email protected]
BRAMAH N. SINGH
Division of CardiologyVeterans Affairs Greater Los Angeles Healthcare System andThe David Geffen School of Medicine at UCLALos Angeles, [email protected]
HARPREET SINGH
Division of CardiologyVeterans Affairs Greater Los Angeles Healthcare System andThe David Geffen School of Medicine at UCLALos Angeles, CAUSA
UPINDERPAL SINGH
Department of Physical Medicine and RehabilitationAll India Institute of Medical SciencesNew [email protected]
lxxviii List of Contributors
SANDRA SIRRS
Vancouver Hospital and Health Sciences CentreVancouver, [email protected]
ERIK A. SISTERMANS
VU University Medical CentreAmsterdamThe [email protected]
CHRISTINE SKERKA
Department of Infection BiologyLeibniz Institute for Natural Products Research and [email protected]
MARC SLAWIK
Medical ClinicLudwig-Maximilians-UniversityMunichGermany
AUGUST H. M. SMELT
Department of General Internal MedicineLeiden University Medical CenterLeidenThe [email protected]
A. GORDON SMITH
Department of NeurologyUniversity of Utah School of MedicineSalt Lake City, [email protected]
EMILY SMITH
La Jolla Institute for Allergy and Immunology Division ofInflammation BiologyLa Jolla, CAUSA
M. IAIN SMITH
Department of MedicineUniversity of Virginia School of MedicineCharlottesville, VAUSA
ERIC A. SOBIE
Pharmacology and Systems TherapeuticsMount Sinai School of MedicineNew York, [email protected]
LUBOMIR SOKOL
Division of Malignant HematologyDepartment of Interdisciplinary OncologyH. Lee Moffitt Cancer Center and Research InstituteUniversity of South FloridaTampa, [email protected]
GÖKSEL SOMAY
Department of NeurologyHaydarpaşa Numune Educational and Research [email protected]
WILLIAM J. SPEAKE
Department of General SurgeryUniversity HospitalNottinghamUK
JO SPENCER
Division of Immunology, Infection & InflammationImmunobiology DepartmentKings CollegeLondonUK
ANNE-DORTE SPERFELD
Department of NeurologyUniversity of [email protected]
ODED SPERLING
Department of Human Molecular Genetics and BiochemistryTel Aviv [email protected]
SONJA STÄNDER
Department of DermatologyUniversity Hospital of [email protected]
NICOLE STANKUS
Department of NephrologyUniversity of ChicagoChicago, [email protected]
ROLAND STAUD
University of FloridaGainesville, [email protected]
List of Contributors lxxix
ANDREW C. STEER
Centre for International Child HealthDepartment of PediatricsUniversity of MelbourneMelbourne, [email protected]
IOANNIS STEFANIDIS
Department of Nephrology, Medical SchoolUniversity of [email protected]
JÜRGEN M. STEIN
Department of Medicine IZAFESJ. W. Goethe-University [email protected]
DANIELA STEINBERGER
BioscientiaCenter for Human [email protected]
ORTRUD K. STEINLEIN
Ludwig-Maximilians-University of Munich School ofMedicineInstitute of Human [email protected]
ULRICH STEPHANI
Clinics for Neuropediatrics of Kiel [email protected]
SUNCANICA LJUBIN STERNAK
Department of VirologyCollaborating Centre WHO for VirologyCroatian National Institute of Public [email protected]
GERALD STÖBER
Department of Psychiatry and PsychotherapyUniversity of [email protected]
EGGERT STOCKFLETH
Department of DermatologySkin Cancer Center CharitéUniversity Hospital of [email protected]
SYLVIA STÖCKLER-IPSIROGLU
Biochemical Genetics and National Neonatal ScreeningLaboratories Department of General PediatricsUniversity Children’s Hospital [email protected]
CLAUDE STOLL
Laboratoire de Génétique MédicaleFaculté de Mé[email protected]
GUIDO STOLL
Department of NeurologyUniversity of [email protected]
JAMES K. STOLLER
Department of Pulmonary and Critical Care MedicineSection of Respiratory TherapyCleveland Clinic Lerner College of MedicineCleveland, [email protected]
GISELA STOLTENBURG-DIDINGER
Institute of NeuropathologyCampus Charité[email protected]
MARVIN J. STONE
Baylor Sammons Cancer CenterBaylor University Medical CenterDallas, [email protected]
ALEXANDER STORCH
Department of NeurologyTechnical University of [email protected]
BJÖRN STORK
Department of Internal Medicine IUniversity of [email protected]
lxxx List of Contributors
CONSTANTINE STRATAKIS
Program on Developmental Endocrinology & GeneticsNational Institute of Child Health and Human DevelopmentBethesda, [email protected]
MICHAEL STRAUB
Department of Urology and Pediatric UrologyUrolithiasis Research GroupUniversity of [email protected]
ERICH C. STRAUSS
Gladstone Institute of Virology and ImmunologyUniversity of CaliforniaSan Francisco, [email protected]
OLAF STRAUSS
Experimental OphthalmologyDepartment of OphthalmologyUniversity of [email protected]
EUGEN-MATTHIAS STREHLE
Neuromuscular GeneticsInternational Centre for LifeNewcastle upon [email protected]
ROBERT M. STRIETER
Department of MedicineUniversity of Virginia School of MedicineCharlottesville, [email protected]
MICHAEL STRUPP
Department of NeurologyLudwig-Maximilians-UniversityKlinikum Groß[email protected]
MICHAEL STÜRZL
Division of Molecular and Experimental SurgeryDepartment of SurgeryUniversity of Erlangen-NurembergErlangenGermanyMichael.Stuerzl@chir.imed.uni-erlangen.de
HELEN C. SU
Molecular Development SectionLaboratory of ImmunologyNIAID, NIHBethesda, [email protected]
HOLGER SUDHOFF
Department of Otorhinolaryngology/Head and Neck SurgeryUniversity of [email protected]
PETER H. SUGDEN
NHLI Division, Faculty of MedicineImperial College LondonLondonUK
RICHARD J. SUGRUE
Division of Molecular and Cell BiologySchool of Biological SciencesNanyang Technological [email protected]
ELEANOR M. SUMMERHILL
Warren Alpert Medical School at Brown UniversityProvidence, RIUSA
DEMING SUN
Department of Ophthalmology and Visual SciencesUniversity of LouisvilleLouisville, KYUSA
CORD SUNDERKÖTTER
Department of DermatologyUniversity Hospital of [email protected]
MANISH SUNEJA
Division of NephrologyDepartment of Internal MedicineUniversity of Iowa College of MedicineIowa City, [email protected]
TIINA SUOMINEN
NeurogeneticsUniversity of [email protected]
List of Contributors lxxxi
KANYA SUPHAPEETIPORN
Division of Medical Genetics and MetabolismDepartment of PediatricsChulalongkorn UniversityBangkokThailand
SANKAR SURENDRAN
Internal MedicineThe University of Texas Medical BranchGalveston, [email protected]
CHITRA SURI
Westchester Community CollegeValhalla, [email protected]
MILLICENT SUTTON
Laboratory of Complement BiologyNew York Blood CenterNew York, NYUSA
KUNIHIKO SUZUKI
Neuroscience CenterUniversity of North Carolina School of MedicineChapel Hill, [email protected]
YOICHI SUZUKI
Department of Medical GeneticsTohoku University School of [email protected]
EHTESHAMUDIN SYED
Division of Nephrology and HypertensionFeinberg School of MedicineNorthwestern UniversityChicago, ILUSA
JACOB I. SZNAJDER
Division of Pulmonary and Critical CareFeinberg School of MedicineNorthwestern UniversityChicago, ILUSA
KEIYA TADA
Departments of Pediatrics and Medical GeneticsTohoku University School of MedicineSendaiJapan
AKIHIRO TAKATSU
Department of Forensic MedicineJikei University School of [email protected]
FILIPPO TAMANINI
Department of Cell Biology and GeneticsCenter for Biomedical GeneticsErasmus University Medical CenterRotterdamThe [email protected]
MOTOKO TANAKA
Department of NephrologyAkebono [email protected]
LAURA M. TANNER
Department of PediatricsTurku University [email protected]
AYALEW TEFFERI
Division of HematologyMayo Clinic College of MedicineRochester, [email protected].
BIN SING TEH
Department of Radiology/Radiation OncologyBaylor College of Medicine and The Methodist HospitalHouston, TXUSA
BIN TEAN TEH
Laboratory of Cancer GeneticsVan Andel Research InstituteGrand Rapids, [email protected]
JAIME TEJEDOR
Department of OphthalmologyHospital Ramón y [email protected]
CEVAHIR TEKCAN
Barbaros Mh. Başkan Sk. Özlem Sit.Koş[email protected]
lxxxii List of Contributors
HUGO TEN CATE
Laboratory for Clinical Thrombosis and HemostasisDepartment of Internal MedicineMaastricht UniversityMaastrichtThe [email protected]
HARRIET S. TENENHOUSE
Department of Human GeneticsMontreal Children’s Hospital Research InstituteMcGill UniversityMontreal, [email protected]
HIROKI TERAGAWA
Department of Medicine and Molecular ScienceGraduate School of Biomedical SciencesHiroshima [email protected]
VLADIMIR TESAR
Department of NephrologyCharles UniversityPragueCzech [email protected]
ULRICH THALHEIMER
Department of Liver Transplantation and HepatobiliarySurgeryRoyal Free HospitalHampstead, LondonUK
KUMARASAMY THANGARAJ
Centre for Cellular and Molecular [email protected]
MANISH THAPAR
Division of Gastroenterology and HepatologyUniversity of MissouriColumbia, MOUSA
TANYA THIAGARAJAH
Learning Disability ServiceNHS LothianEdinburghUK
HAGEN THIEME
Department of OphthalmologyJohannes-Gutenberg-University [email protected]
JAMES B. THODEN
Department of BiochemistryUniversity of WisconsinMadison, WIUSA
CHRISTIE P. THOMAS
Division of Nephrology, Department of Internal MedicineUniversity of Iowa College of MedicineIowa City, [email protected]
ALLAN D. THOMSON
Molecular Psychiatry Laboratory, Windeyer Institute ofMedical SciencesDepartment of Psychiatry and Behavioural SciencesRoyal Free and University College LondonLondon Medical SchoolLondonUK
DAVID J. TIMSON
School of Biological SciencesQueen’s University BelfastMedical Biology [email protected]
VALERIA TIRANTI
Unit of Molecular NeurogeneticsPierfranco and Luisa Mariani Center for the Study ofChildren’s Mitochondrial DisordersIRCCS Foundation Neurological Institute“CBesta”[email protected]
JAY A. TISCHFIELD
Nelson Laboratory, Department of GeneticsRutgers UniversityPiscataway, NJUSA
CHEE-KEONG TOH
Department of Medical OncologyNational Cancer [email protected]
YARON TOMER
Division of EndocrinologyUniversity of CincinnatiCincinnati, OHUSA
RADE TOMIC
Department of MedicineAtlanta VA Medical CenterAtlanta, GAUSA
List of Contributors lxxxiii
JOEL MICHELS TOPF
Chronic Kidney Disease ClinicsDetroit, [email protected]
HARRYS A. TORRES
Department of Infectious DiseasesInfection Control and Employee HealthThe University of Texas M. D. Anderson Cancer CenterHouston, TXUSA
JEAN-NICOLAS TOURNIER
Unité Interactions Hôte-PathogèneDépartement de Biologie des Agents TransmissiblesCentre de Recherches du Service de Santé des ArméesLa [email protected]
MARY I. TOWNSLEY
Department of Physiology and the Center for Lung BiologyUniversity of South Alabama College of MedicineMobile, [email protected]
KLAUS V. TOYKA
Department of Neurology and Clinical Research Group forMS and NeuroimmunologyUniversity of [email protected]
MARIA GRAZIA TOZZI
Department of BiologyUniversity of PisaPisaItaly
MICHAEL TRAUNER
Division of Gastroenterology and HepatologyMedical University of [email protected]
HEIKO TRAUPE
Department of DermatologyUniversity Hospital of MuensterMuensterGermany
FRANCO TREVISANI
Dipartimento di Medicina Interna, Cardioangiologia,EpatologiaAlma Mater Studiorum Università di BolognaBolognaItaly
KATHY TRIANTAFILOU
Infection and Immunity GroupSchool of Life SciencesUniversity of [email protected]
CHRISTOS TRIANTOS
Department of Liver Transplantation and HepatobiliarySurgeryRoyal Free HospitalHampstead, LondonUK
ROSARIO RICH TRIFILETTI
Department of Pediatrics and NeurologyMorristown Memorial Hospital Atlantic Health SystemMorristown, NJUSA
BARBARA L. TRIGGS-RAINE
Department of Biochemistry and Medical GeneticsUniversity of ManitobaWinnipeg, [email protected]
FRANCESCO TROTTA
Section of RheumatologyDepartment of Clinical and Experimental MedicineUniversity of Ferrara Medical [email protected]
TERENCE K. TROW
Pulmonary Hypertension CenterYale University School of MedicineNew Haven, [email protected]
HAN-MOU TSAI
Division of HematologyMontefiore Medical Center and Albert Einstein College ofMedicineNew York, [email protected]
CARSTEN TSCHÖPE
Center for Cardiovascular ResearchCharité[email protected]
HAYRETTIN TUMANI
Department of NeurologyUniversity of [email protected]
lxxxiv List of Contributors
BENJAMIN D. TYRRELL
Division of CardiologyWalter Mackenzie CenterUniversity of AlbertaEdmonton, ABCanada
BJARNE UDD
Department of Medical GeneticsVaasa Central HospitalUniversity of [email protected]
ANSELM UEBING
Adult Congenital Heart Disease UnitRoyal Brompton and Harefield NHS [email protected]
TAKESHI UEHARA
Department of Laboratory MedicineShinshu University School of MedicineMatsumotoJapan
SEMA UGURALP
Department of Pediatric SurgeryTurgut Ozal Medical CenterInonu [email protected]
JOHANNES UHL
Scil Proteins Production GmbHHalleGermany
JOUNI UITTO
Department of Dermatology and Cutaneous BiologyJefferson Medical CollagePhiladelphia, [email protected]
MANGAJJI R. UMAPATHI
Maternity and Child Welfare CenterKanjhawalaNew DelhiIndia
ALEXANDER UNRATH
Department of NeurologyUniversity of UlmUlmGermany
IRIS UNTERBERGER
Department of NeurologyMedical University of [email protected]
ROBERT J. UNWIN
Centre for Nephrology and Department of PhysiologyRoyal Free and University College Medical SchoolUniversity College [email protected]
ZSOLT URBAN
Departments of Pediatrics and GeneticsWashington University School of MedicineSt. Louis, [email protected]
INA L. URBATSCH
Department of Cell Biology and BiochemistryTexas Tech University Health Sciences CenterLubbock, [email protected]
JANET Y. URIU-ADAMS
Department of NutritionUniversity of California at DavisDavis, [email protected]
HOPE E. URONIS
Medicine, Pharmacology and Cancer BiologyDuke UniversityDurham, [email protected]
JOCHEN UTIKAL
Department of Dermatalogy, Venereology and AllergologyUniversity Medical Centre MannheimRuprechts-Karls-University of [email protected]
ANDREA L. UTZ
Neuroendocrine UnitMassachusetts General HospitalBoston, [email protected]
GABRIEL I. UWAIFO
Division of EndocrinologyUniversity of Mississippi Medical CenterJackson, MSUSA
List of Contributors lxxxv
MARIO VACCARO
Institute of DermatologyPoliclinico [email protected]
MARIZ VAINZOF
Human Genome Research CenterDepartment of Genetics and Evolutionary BiologyInstitute of BiosciencesUniversity of São PauloSão PauloBrazil
MARIAN VALKO
Faculty of Chemical and Food TechnologySlovak Technical [email protected]
GERT VAN ASSCHE
Division of GastroenterologyUniversity Hospital [email protected]
BRUNO VANDE BERG
Departments of Nephrology and RadiologyCliniques Universitaires [email protected]
GEORGES VAN DEN BERGHE
University of [email protected]
GER J. VAN DER VUSSE
Cardiovascular Research InstituteMaastricht UniversityMaastrichtThe [email protected]
HANNEKE M. VAN DER STRAATEN
Department of HaematologyUniversity Medical Center UtrechtUtrechtThe [email protected]
WIM VAN HUL
Department of Medical GeneticsUniversity and University Hospital of [email protected]
PETER VON DEN DRIESCH
Center for Skin DiseasesDepartment of Dermatology and AllergologyStuttgart [email protected]
CARLA VAN DER KALLEN
Laboratory of Metabolism and Vascular MedicineUniversity of MaastrichtMaastrichtThe [email protected]
ALBERT H. VAN GENNIP*Laboratory of Biochemical Genetics, Clinical Genetics CenterMaastricht University Medical CenterMaastrichtThe Netherlands
ANDRÉ B. P. VAN KUILENBURG
Laboratory for Genetic Metabolic DiseasesAcademic Medical CenterUniversity of AmsterdamAmsterdamThe [email protected]
TOIN H. VAN KUPPEVELT
Department of Matrix BiochemistryNijmegen Centre for Molecular Life SciencesNijmegenThe [email protected]
GEERT VAN LOO
Department of Molecular BiologyGhent University, ZwijnaardeGhentBelgium
BARBARA C. VAN MUNSTER
Department of Clinical Epidemiology and BiostatisticsAcademic Medical CenterUniversity of AmsterdamAmsterdamThe [email protected]
MAURICE A. M. VAN STEENSEL
Department of DermatologyUniversity Hospital MaastrichtMaastrichtThe [email protected]
FILIP VANHOENACKER
Department of Medical GeneticsUniversity of AntwerpAntwerpBelgium
* deceased
lxxxvi List of Contributors
SERGIO L. VARGAS
University of Chile School of [email protected]
MANISH KUMAR VARSHNEY
Department of OrthopedicsAll India Institute of Medical SciencesNew DelhiIndia
NOSRATOLA D. VAZIRI
Division of Nephrology and HypertensionUCI Medical CenterIrvine, [email protected]
LEO F. VERDONCK
Department of HaematologyUniversity Medical Center UtrechtUtrechtThe [email protected]
NATHALIE VERGNOLLE
Department of Pharmacology and TherapeuticsThe University of CalgaryCalgary, [email protected]
ESSI VIDING
Department of PsychologyUniversity [email protected]
MIIKKA VIKKULA
Laboratory of Human Molecular GeneticsChristian de Duve Institute of Cellular PathologyUniversité Catholique de [email protected]
ANNA VILLA
CNR-Istituto Tecnologie [email protected]
ANGELA VINCENT
Weatherall Institute of Molecular MedicineJohn Radcliffe [email protected]
MARCO VINCETI
Department of Public Health SciencesUniversity of Modena and Reggio EmiliaModenaItaly
JOHN VISSING
Neuromuscular Clinic and Research UnitDepartment of NeurologyNational University [email protected]
NICHOLAS J. VOGELZANG
Nevada Cancer InstituteLas Vegas, NYUSA
RAINER VOISARD
Department of Internal Medicine II – CardiologyUniversity of [email protected]
LUCA VOLTERRANI
Department of RadiologyUniversity of [email protected]
STEPHAN VOM DAHL
Department of Internal MedicineSt. Franziskus-Hospital, Academic Teaching HospitalUniversity of [email protected]
CHRISTINE A.F. VON ARNIM
Department of NeurologyUlm [email protected]
YSKERT VON KODOLITSCH
Heartcenter, CardiologyUniversity Hospital [email protected]
CAROLINA VON REITZENSTEIN
Mannheim University of Applied ScienceInstitut für Instrumentelle Analytik und [email protected]
List of Contributors lxxxvii
KURT VON FIGURA
Department of BiochemistryGeorg-August-University [email protected]
GERD E. VON UNRUH
Department of Internal MedicineUniversity of [email protected]
SÖNKE VON WEIHE
Department of General-, Visceral- and Pediatric SurgeryUniversity Hospital DuesseldorfHeinrich-Heine-UniversityDuesseldorfGermanysoenke.vonweihe@med.uni-duesseldorf.de
FRANÇOISE VUILLIER
Unité d’Immuno-Hématologie et d’ImmunopathologieInstitut [email protected]
MARTIN WABITSCH
Division of Pediatric Endocrinology and DiabetesUniversity of [email protected]
HANS WADENVIK
Hematology SectionDepartment of Internal MedicineSahlgrenska University [email protected]
NITIN WADHANI
Division of CardiologyVeterans Affairs Greater Los Angeles Healthcare System andThe David Geffen School of Medicine at UCLALos Angeles, CAUSA
ANTON J. M. WAGENMAKERS
School of Sport and Exercise SciencesUniversity of [email protected]
CARSTEN A. WAGNER
Institute of Physiology and Zurich Center for IntegrativeHuman PhysiologyUniversity of [email protected]
JEFFREY C. WAGNER
Department of NeurologyUniversity of Utah School of MedicineSalt Lake City, [email protected]
SIEGFRIED WALDEGGER
University Children’s HospitalPhillips UniversityMarburgGermanysiegfried.waldegger@mailer.uni-marburg.de
MARGARET R. WALLACE
Department of Molecular Genetics and MicrobiologyUniversity of FloridaGainesville, [email protected]
CARINA WALLGREN-PETTERSSON
Departments of Medical GeneticsUniversity of Helsinki and Folkhä[email protected]
GERD WALZ
Department of NephrologyUniversity Medical Center [email protected]
RONALD J. A. WANDERS
Laboratory of Genetic Metabolic DisordersAcademic Medical CenterUniversity of AmsterdamAmsterdamThe [email protected]
DONG WANG
Colleen Giblin Laboratories for Pediatric Neurology ResearchDepartment of NeurologyColumbia UniversityNew York, NYUSA
PING WANG
The Feinstein Institute for Medical ResearchManhasset, [email protected]
XINKANG WANG
Wyeth ResearchDiscovery Translational MedicineCollegeville, PAUSA
lxxxviii List of Contributors
DEIRDRE WARD
Inherited Cardiovascular Disease GroupThe Heart HospitalUniversity College London HospitalsNHS Trust and Institute of Cardiovascular ScienceUniversity College LondonLondonUK
MATTHEW L. WARMAN
Department of Genetics and Center for Human GeneticsCase School of MedicineCleveland, [email protected]
HIROSHI WATANABE
Division of Clinical PharmacologyDepartments of Medicine and PharmacologyVanderbilt University School of MedicineNashville, [email protected]
TIMOTHY WATSON
Hemostasis, Thrombosis and Vascular Biology UnitUniversity Department of Medicine, City [email protected]
CHRISTOPH K. WEBER
Department of GastroenterologyClinic [email protected]
RAINER WEBER
Department of OtorhinolaryngologyKlinikum [email protected]
STEFANIE WEBER
Laboratory for Molecular GeneticsDepartment for Pediatric NephrologyChildren’s University [email protected]
YVONNE G. WEBER
Department of Neurology of the University of UlmZentrum für Klinische [email protected]
PETRA WECKERLE
University Eye Hospital [email protected]
JEANNE Y. WEI
University of Arkansas for Medical Sciences, GRECC andCAVHSLittle Rock, [email protected]
JULIA WEIHRAUCH
Department of DermatologyUniversity CologneCologneGermany
TRACEY WEILER
Division of RheumatologyCincinnati Children’s Hospital Medical CentreCincinnati, [email protected]
DAVID A. WEINSTEIN
Division of Pediatric EndocrinologyUniversity of Florida College of MedicineGainsville, FLUSA
LEE S. WEINSTEIN
Metabolic Diseases BranchNational Institute of Diabetes, Digestive, and KidneyDiseasesNational Institutes of HealthBethesda, [email protected]
JEFFREY P. WEISS
Department of UrologyWeill Medical College of Cornell UniversityNew York, NYUSA
GÜNTER WEISS
Department of Internal Medicine IMedical UniversityInnsbruckAustria
WILLIAM J. WELCH
Department of MedicineGeorgetown UniversityWashington, [email protected]
MICHAEL WELLER
Department of NeurologyUniversity Hospital [email protected]
List of Contributors lxxxix
KATRIN WELT
Department of Dermatology and AllergologyUniversity of UlmUlmGermany
SHARON L. WENGER
Department of PathologyWest Virginia UniversityMorgantown, [email protected]
MATTHIAS WENNING
Clinic for Gastroenterology, Hepatology and InfectiologyHeinrich-Heine-UniversityDuesseldorfGermanyMatthias.Wenning@uni-duesseldorf.de
SEBASTIAN WESSELBORG
Department of Internal Medicine IUniversity of [email protected]
ANDY WESSELS
Department of Cell Biology and AnatomyCardiovascular Developmental Biology CenterMedical University of South CarolinaCharleston, [email protected]
RAINER WESSELY
Heart [email protected]
DIRK WESTERMANN
Center for Cardiovascular ResearchCharité[email protected]
MATTHIAS WETTSTEIN
Internal Medicine IPassau [email protected]
DAVID C. WHITCOMB
Division of Gastroenterology,Hepatology and NutritionUniversity of PittsburghPittsburgh, [email protected]
ROBERT P. WHITEHEAD
Division of Hematology/OncologyUniversity of Texas Medical BranchGalveston, [email protected]
JAMES G. WHITE
Laboratory Medicine and PathologyUniversity of MinnesotaMinneapolis, [email protected]
MICHAEL P. WHYTE
Center for Metabolic Bone Disease and Molecular ResearchShriners Hospitals for Children and Department of MedicineWashington University School of MedicineSt. Louis, [email protected]
DAN WICHTERLE
2nd Department of Internal Medicine1st Medical SchoolCharles UniversityPragueCzech [email protected]
RALF WIENECKE
Department of DermatologyTuberous Sclerosis CenterLudwig-Maximilian-UniversityMunichGermanyralf.wienecke@lrz.uni-muenchen.de
JOLANTA WIERZBA
Department of Pediatrics, Hematology, Oncology andEndocrinologyMedical University of [email protected].
HOLGER S. WILLENBERG
Department of Endocrinology, Diabetes and RheumatologyUniversity [email protected]
RUTH WILLIAMS
Department of Pediatric NeurologyThe Evelina Children’s [email protected]
xc List of Contributors
OLAF WITT
Department of Pediatric Oncology, Hematology andImmunologyUniversity of HeidelbergHeidelbergGermany
MARLYS H. WITTE
Department of SurgeryUniversity of ArizonaTucson, AZUSA
CRISTINA WOELLNER
Division of Rheumatology and Clinical ImmunologyUniversity Hospital [email protected]
FENELLA WOJNAROWSKA
Department of DermatologyThe Churchill [email protected]
BARRY WOLF
Department of PediatricsUniversity of Connecticut School of MedicineHartford, [email protected]
GUNTER WOLF
Department of Internal Medicine IIIUniversity Hospital [email protected]
HANS WOLF
Institute of Medical MicrobiologyUniversity of [email protected]
NICOLE I. WOLF
Department of Pediatric NeurologyUniversity of Heidelberg Medical CentreHeidelbergGermany
RONNI WOLF
The Dermatology UnitKaplan Medical [email protected]
JOSEPH I. WOLFSDORF
Department of EndocrinologyChildren’s Hospital BostonBoston, [email protected]
JOHN WOLSTENHOLME
Institute of Human GeneticsUniversity of NewcastleNewcastle upon [email protected]
ANDREW L. WONG
Department of SurgeryThe University of CalgaryCalgary, ABCanada
DEREK A. WONG
Childrens Hospital Los AngelesLos Angeles, [email protected]
TOM Y. WOO
Department of MedicineThe Univesity of CalgaryCalgary, ABCanada
KATIE A. WOODS
Pediatric Endocrinology SectionDepartment of EndocrinologySt. Bartholomew’s HospitalLondonUK
TRACY J. WRIGHT
Institute of Medical GeneticsUniversity of ZurichSchwerzenbachSwitzerland
KLAUS WROGEMANN
Department of Biochemistry and Medical GeneticsUniversity of ManitobaWinnipeg, [email protected]
RONGQIAN WU
Department of SurgeryNorth Shore University Hospital and Long Island JewishMedical CenterManhasset, [email protected]
List of Contributors xci
MICHAEL T. WUNDERLICH
Department of NeurologyOtto-von-Guericke-University [email protected]
WIM WUYTS
Department of Medical GeneticsUniversity of AntwerpAntwerpBelgium
HUI XU
Institute of Endemic DiseasesNorman Bethune College of Medical SciencesJilin UniversityChangchunP.R. [email protected]
DHIRAJ YADAV
Division of GastroenterologyHepatology and NutritionUniversity of PittsburghPittsburgh, [email protected]
HIROYUKI YAMAGISHI
Department of PediatricsKeio University School of [email protected]
TAKASHI YAMAKI
Department of Plastic and Reconstructive SurgeryTokyo Women’s Medical [email protected]
XIMING J. YANG
Department of PathologyNorthwestern UniversityChicago, ILUSA
ZHIRONG YAO
Medical Mycology LaboratoryXinhua Hospital, School of MedicineShanghai Jiaotong [email protected]
RABAH BEN YAOU
KARINA YAZDANBAKHSH
Laboratory of Complement BiologyNew York Blood CenterNew York, [email protected]
HUI-JUN YE
Department of CardiologySecond Xiangya HospitalCentral South UniversityChangsha, HunanPeople’s Republic of China
ORHAN YILDIZ
Department of Infectious DiseasesFaculty of MedicineErciyes [email protected]
KATSUHIKO YOSHIZAWA
Drug Safety Research LaboratoriesAstellas Pharma [email protected]
JASON X.-J. YUAN
Division of Pulmonary and Critical Care MedicineDepartment of MedicineUniversity of California at San DiegoLa Jolla, [email protected]
PIN YUE
Washington University in St. Louis School of MedicineSt. Louis, MIUSA
TETSUO YUKIOKA
Department of Emergency and Critical Care MedicineTokyo Medical UniversityShinjuku, TokyoJapan
ELAINE H. ZACKAI
Department of PediatricsDivision of Human and Molecular GeneticsChildren’s Hospital of PhiladelphiaPhiladelphia, [email protected]
EJAZ ZAIDI
Elipsis BiotherapeuticsToronto, [email protected]
xcii List of Contributors
ILSE MARIA ZALAMAN
Department of Otolaryngology and Head and Neck SurgeryUniversity of TuebingenTuebingenGermany
DINA J. ZAND
Department of Pediatrics, Division of Genetics andMetabolismChildren’s National Medical CenterWashington, [email protected]
FREDERICO ZARA
Muscular and Neurodegenerative Disease UnitUniversity of GenoaGenoaItaly
CHRISTOPHER K. ZARINS
Division of SurgeryStanford University School of MedicineStanford, [email protected]
MAYANA ZATZ
Human Genome Research Center, Department of Geneticsand Evolutionary BiologyInstitute of BiosciencesUniversity of São PauloSão PauloBrazil
JOERG ZEHELEIN
Department of Internal Medicine IIIUniversity Hospital [email protected]
CHRISTINA ZEITZ
Institut de la VisionLaboratoire de Physiopathologie Cellulaire et Moléculaire dela Rétine-INSERMUniversité Pierre et Marie [email protected]
DARRYL C. ZELDIN
Laboratory of Respiratory BiologyNIH/NIEHSResearch Triangle Park, [email protected]
MARTIN ZENKER
Institute of Human GeneticsUniversity of Erlangen-NurembergErlangenGermanyMartin.Zenker@humgenet.uni-erlangen.de
HANS-PETER ZENNER
Department of Otolaryngology and Head and Neck SurgeryUniversity of [email protected]
INGA ZERR
Department of NeurologyNational Reference Center for TSE SurveillanceGeorg-August [email protected]
KLAUS ZERRES
Institute of Human GeneticsAachen University of [email protected]
MASSIMO ZEVIANI
Unit of Molecular NeurogeneticsNational Neurological Institute “C. Besta”[email protected]
SHUI-PING ZHAO
Department of Cardiology, Second Xiangya HospitalCentral South UniversityChangsha, HunanPeople’s Republic of [email protected]
YAOFENG ZHAO
Karolinska Institute, Department of Laboratory MedicineKarolinska University Hospital [email protected]
YUN ZHAO
Laboratory of Respiratory BiologyNIH/NIEHSResearch Triangle Park, NCUSA
XIAOYAN ZHOU
Ochsner Clinic FoundationNew Orleans, [email protected]
STEPHAN ZIERZ
Department of NeurologyUniversity of Halle-WittenbergHalleGermany
List of Contributors xciii
CHRISTIAN ZIETZ
Department of PathologyTechnical University of [email protected]
DIANA J. ZIMMERMANN
Department of UrologyUniversity of BonnBonnGermany
MARC ZIMMERMANN
Cardiovascular DepartmentHôpital de La [email protected]
PETER F. ZIPFEL
Department of Infection BiologyFriedrich-Schiller-UniversityJenaGermanypeter.zipfel@hki-jena.de
BIRGIT ZIRN
Institute of Human GeneticsGiessenGermanybirgit.zirn@humangenetik.med.uni-giessen.de
ARMIN ZITTERMANN
Department of Thoracic and Cardiovascular SurgeryHeart and Diabetes Center NRWRuhr UniversityBad [email protected]
CHRISTOS C. ZOUBOULIS
Department of Dermatology, Venerology, Allergology andImmunologyDessau Medical [email protected]
GEORGE S. ZUBENKO
Department of PsychiatrySchool of MedicineUniversity of PittsburghPittsburgh, [email protected]
ORSETTA ZUFFARDI
Genetica MedicaUniversità di [email protected]
ITSHAK ZUSMAN
Koret School of Veterinary Medicine, Food andEnvironmental Quality SciencesHebrew University of [email protected]
xciv List of Contributors