link to cv.doc

CURRICULUM VITAEJanuary 8, 2007

PERSONAL DATAName: Raymond A. Daynes

Birth Date: October 6, 1944

Birthplace: Los Angeles, California

Citizenship: United States of America

Work Address: Department of Pathology, 5B412 SOMUniversity of Utah School of Medicine30 North 1900 EastSalt Lake City, UT 84132-2501Phone: 801-581-3013Fax: 801-581-8946Email: [email protected]

EDUCATIONBaccalaureate Degree: 1967 B.A.

California State University, Fullerton, California

Advanced Degrees: 1969 M.A. in Molecular Biology California State University, Fullerton, California

1972 Ph.D. in Immunology Purdue University, Lafayette, Indiana

Postdoctoral Fellowship: 1972-4 Laboratory of Dr. G.A. Granger, Cellular Immunology University of California, Irvine, California.

PROFESSIONAL EXPERIENCEFull-time Positions:

1975-1978 Assistant Professor of Pathology U of Utah Medical School1978-1983 Associate Professor of Pathology U of Utah Medical School1978-1983 Associate Professor of Obstetrics and

GynecologyU of Utah Medical School

1983-present Professor of Pathology U of Utah Medical School1983-1985 Professor of Obstetrics and


1985-present Head, Division of Cell Biology and Immunology

U of Utah Medical School

1986-present Associate Chairman of Pathology U of Utah Medical School1991-2004 Associate Director of Research SLC VA Hospital, GRECC1992-present Recipient, George J. Weber

Presidential Endowed Chair in Immunology

U of Utah Medical School

Part-time Positions:1985-2003 Adjunct Professor of Obstetrics and


1985-present Adjunct Professor of Internal Medicine U of Utah Medical School

Editorial Experience:Aging: Immunology and Infectious Disease RefereeArchives of Dermatological Research RefereeBiodrugs RefereeBlood RefereeBrain, Behavior, and Immunity RefereeCellular Immunology RefereeDehydroepiandrosterone (DHEA) and Aging. New York

Academy of Sciences, Vol. 774 (1995)Editor

Developmental and Comparative Immunology RefereeEndocrinology RefereeExperimental and Clinical Photoimmunology. CRC Press,

Florida, Vols. I and II (1983), Vol. III (1986).Editor

Infection and Immunity RefereeInternational Immunology RefereeInternational Journal of Immunopharmacology RefereeJournal of Clinical Endocrinology & Metabolism RefereeJournal of Clinical Investigation RefereeJournal of Experimental Medicine RefereeJournal of Immunology RefereeJournal of Leukocyte Biology RefereeInternational Journal of Immunopharmacology RefereeLife Sciences RefereeMicrobial Pathogenesis Editorial Board

MemberMolecular Biology of the Cell RefereeProceedings of the National Academy of Sciences RefereeProceedings of the Society for Experimental Biology and

MedicineReferee

Society for Experimental Biology and Medicine RefereeTransplantation Referee

Research Awards:Active Cross-protective Vaccines Against Emerging Infectious Agents 12/1/04 -

11/30/07NIH grant (subcontract Principal Investigator)

Transdermal Immunization 10/1/06 – 9/30/07Corium International, Inc

Pending Systemic Immunization and Common Mucosal Immunity 12/1/05 -

11/30/07NIH grant (Principal Investigator)

Pro-inflammatory Roles of Glucocorticoids in Host Defense & Disease 4/1/06 - 3/31/11NIH grant (Principal Investigator)

Historical Regulation of Mucosal Immunity by Vitamin D3 5/1/99 - 4/30/06

NIH grant (Principal Investigator) Control of Efferent Immune Responses 8/1/79 - 1/31/04

Daynes’ CV of 22 September 29, 2006

NIH grant (Principal Investigator) PPAR in Aging and Disease 11/1/01 - 10/31/02

University of Utah Research Foundation Seed Grant (Principal Investigator) Glycoalkaloid Modulation of Innate Defenses 3/1/98 - 2/28/99

University of Utah Research Foundation grant (Principal Investigator) Induction of Common Mucosal Immunity to Agents of STD's 2/1/96 - 1/31/99

NIH grant (Co-Investigator) PDGF Effects on T-cell Behavior in Aging 4/1/93 - 3/31/98

NIH grant (Principal Investigator) Regulation and Control of the Mammalian Immune System 4/1/93 - 3/31/96

Paradigm Biosciences, Inc. grant (Principal Investigator) Immunologic Reconstitutiton of Thermally Injured Animals 2/1/92 - 1/31/96

NIH grant (Co-Investigator) Preservation of Immunologic Responsiveness Following Trauma 4/1/92 - 3/31/95

Office of Naval Research grant (Co-Principal Investigator) Immunobiology of Ultraviolet Light-Induced Tumors 8/1/82 - 7/31/94

NIH grant (Principal Investigator) Restoration of Immune Function in the Elderly with DHEA 10/1/91 - 9/30/93

GRECC-VA RAG grant (Principal Investigator) Effects of Ultraviolet Radiation on Pathogenesis and Immunity 9/4/90 - 9/3/91

EPA grant (Co-Investigator) Ultraviolet Light Radiation and Imunoregulation 2/1/77 - 1/31/90

NIH grant (Principal Investigator)

ADMINISTRATIVE EXPERIENCEAdministrative Positions:

1985-present Head, Division of Cell Biology & Immunology, Dept of Pathology1986-present Associate Chairman, Department of Pathology1986 - 1994 Director, Department of Radiobiology1991-2004 Associate Director of Research, SLC-GRECC (Geriatric Research,

Education and Clinical Center), VA Medical Center1992-present Chairman, George J. Weber Immunology Research Endowment

Committee

Administrative Duties (1993-present):


1980-present Head, Prahl Award Committee1991-1995 Head, Recruitment Committee for the Combined Molecular Biology

Graduate Program1992-19951999-2003

Member, Steering Committee for the Combined Molecular Biology Graduate Program

1992-1998 Member, ACS Institutional Grant Review Committee1993 Independent Reviewer, Faculty Research Grant Proposals1994-1996 Member, University of Utah Academic Senate1994-1999 Member, Oversight Com for Fluorescent Activated Cell Sorter

Facility1994-1999 Member, Center of Excellence in Molecular Hematology Executive

Committee1995 Member, Search Committee for a Chair for the Family and

Preventive Medicine Department 1995-1997 Director, HCI Cell Response and Regulation Program1995-1998 Member, School of Medicine Retention, Promotion, and Tenure

Com.1996 Head, Animal Facilities Needs Assessment Task Force 1996 Member, Search Com. for an Obstetrics & Gynecology Dept. Chair1996 Member, Search Committee for a Pediatrics Department Chair1996-present Member, Basic Scientific Advisory Committee1996-1998 Head, Pathology Department Tenured Faculty Review Committee 1997 Member, Search Committee for Director of Sponsored Projects 1997-1999 Member, IACUC Committee1997-present Member, COEP Center for Cell Signaling 1997-2000 Member, Executive Board of the ARUP Institute for Clinical and

Experimental Pathology 1999-2003 Chair, School of Medicine Retention, Promotion, and Tenure Com.2000-present Member, Intermountain Health Care Recombinant DNA/Institutional

Biosafety Committee2000-2003 Member, RPT Revision Committee2000-present Member, Microbial Pathogenesis Faculty Search Committee2002-present Member, Emma Eccles Jones Building Planning Committee

Professional and Scientific Committees:1981-1982 Ad Hoc Member - Immunological Sciences, NIH1981-1982 Ad Hoc Member - Biological Response Modifiers, NIH1981-1982 Ad Hoc Member - Biological Resources Committee, NIH1982-1986 Ad Hoc Reviewer - Immunobiology, NIH1987-1991 Member - Immunobiology Study Section, NIH1989-1991 CHAIRMAN, Immunobiology Study Section, NIH1991-present Member, NIH Reviewers Reserve (NRR)1994 Chair of FASEB Meeting Minisymposium: "Cytokine and Cytokine

Receptors In Vivo" 1994-1995 Participant, U.S. Army Medical R&D Command Breast Cancer

Research Program peer review1994-1995 Member, FASEB Summer Conference Advisory Committee1994-1996 AAI Programming Mtg. 1995 AAI Co-chair Block Mtg


1996-present External Advisor to the Center for Recombinant Gamete Contraceptive Vaccinogens, University of Virginia

MEMBERSHIPS IN PROFESSIONAL SOCIETIES

Sigma XiAmerican Association of ImmunologistsSociety for Investigative DermatologyAmerican Society of PhotobiologyAmerican Association of PathologistsAmerican Society for Microbiologists

TEACHING RESPONSIBILITIES / ASSIGNMENTSCourses taught (2000-present):

Quarter Role Course# of

StudentsS07 Co-instructor PATH 7880 - Research in Progress 27S07 Co-instructor PATH 7890 - Journal Club 27S07 Instructor PATH 7970 - PhD Thesis Research 1S07 Lecturer PATH 6000 - Medical ImmunologyF06 Course Organizer

& LecturerPATH 5030 – Basic Immunology 46

F06 Co-instructor PATH 7880 – Research in Progress 27F06 Co-instructor PATH 7890 – Journal Club 27F06 Instructor PATH 7970 – PhD Thesis Research 1S06 Co-instructor PATH 7880 - Research in Progress 27S06 Co-instructor PATH 7890 - Journal Club 27S06 Instructor PATH 7970 - PhD Thesis Research 1S06 Lecturer PATH 6000 - Medical ImmunologyF05 Course Organizer

& LecturerPATH 5030 - Basic Immunology 44

F05 Co-instructor PATH 7880 - Research in Progress 28F05 Co-instructor PATH 7890 - Journal Club 28F05 Instructor PATH 7970 - PhD Thesis Research 1F05 Lecturer PATH 6000 - Medical ImmunologyS05 Co-instructor PATH 7880 - Research in Progress 31S05 Co-instructor PATH 7890 - Journal Club 31S05 Instructor PATH 7970 - PhD Thesis Research 1S05 Lecturer PATH 6000 - Medical ImmunologyF04 Course Organizer


F04 Co-instructor PATH 7880 - Research in Progress 25F04 Co-instructor PATH 7890 - Journal Club 25F04 Instructor PATH 7970 - PhD Thesis Research 1F04 Lecturer PATH 6000 - Medical ImmunologySu04 Instructor PATH 7970 – PhD Thesis Research 1S04 Co-instructor PATH 7880 - Research in Progress 20S04 Co-instructor PATH 7890 - Journal Club 20S04 Instructor PATH 7970 - PhD Thesis Research 2S04 Lecturer PATH 6000 - Medical Immunology


F03 Course Organizer & Lecturer

PATH 5030 - Basic Immunology 55

F03 Co-instructor PATH 7880 - Research in Progress 21F03 Co-instructor PATH 7890 - Journal Club 21F03 Instructor PATH 7970 - PhD Thesis Research 2Su03 Instructor PATH 7970 - PhD Thesis Research 3S03 Co-instructor PATH 7880 - Research in Progress 20S03 Co-instructor PATH 7890 - Journal Club 20S03 Instructor PATH 7970 - PhD Thesis Research 3S03 Lecturer PATH 6000 - Medical ImmunologyS03 Lecturer MBIOL 6481 – Cell Biology 35S03 Lecturer ONCSC 6500 – Molecular Mechanisms in

Cancer 36

S03 Lecturer PATH 7310 - Host-Pathogen Interaction 18F02 Co-instructor PATH 7880 - Research in Progress 24F02 Co-instructor PATH 7890 - Journal Club 24F02 Instructor PATH 7970 - PhD Thesis Research 3F02 Course Organizer


Su02 Instructor PATH 7970 - PhD Thesis Research 2S02 Co-instructor PATH 7880 - Research in Progress 13S02 Co-instructor PATH 7890 - Journal Club 13S02 Instructor PATH 7970 - PhD Thesis Research 2S02 Lecturer MBIOL 6480 – Cell Biology 49S02 Lecturer PATH 6000 - Medical Immunology 105F01 Co-instructor PATH 7880 - Research in Progress 15F01 Co-instructor PATH 7890 - Journal Club 15F01 Instructor PATH 7970 - PhD Thesis Research 3F01 Lecturer PATH 5030 - Basic Immunology 40Su01 Instructor PATH 7970 - PhD Thesis Research 3S01 Co-instructor PATH 7880 - Research in Progress 13S01 Co-instructor PATH 7890 - Journal Club 13S01 Instructor PATH 7970 - PhD Thesis Research 3S01 Course Organizer

& LecturerMBIOL 6100– Nuclear Hormone Receptor

Function6

S01 Lecturer MBIOL 6480 – Cell Biology 42S01 Lecturer ONCSC 6700 – Cancer Biology 31S01 Lecturer PATH 6000 - Medical Immunology 105F00 Co-instructor PATH 7880 - Research in Progress 15F00 Co-instructor PATH 7890 - Journal Club 15F00 Instructor PATH 7970 - PhD Thesis Research 3F00 Lecturer PATH 5030 - Basic Immunology 38Su00 Instructor PATH 7970 - PhD Thesis Research 3S00 Co-instructor PATH 7880 - Research in Progress 14S00 Co-instructor PATH 7890 - Journal Club 14S00 Instructor PATH 7970 - PhD Thesis Research 3S00 Lecturer PATH 6000 - Medical Immunology 97S00 Lecturer MBIOL 6480 – Cell Biology 36


Graduate Students Supervised (Committee Chairperson):• SPELLMAN, Craig William, Ph.D. in Experimental Pathology, 1978

Thesis title: Suppression of Anti-syngeneic Tumor Responses by Ultraviolet Light-induced Suppressor T LymphocytesCurrent Employment: Associate Professor, Depts of Internal Medicine, and Immunology and Microbiology, University of North Texas Hlth Science Center

• WOODWARD, Jerold Glen, Ph.D. in Experimental Pathology, 1979Thesis title: Studies on the Cellular Requirements for the In Vitro Generation of a Cell-Mediated Immune Response to Syngeneic Ultraviolet Light-induced TumorsCurrent Employment: Professor, Microbiology & Immunology, University of Kentucky Medical School

• ROBERTS, Lee Knight, Ph.D. in Experimental Pathology, 1980Thesis title: Studies into the Immunologic Responses Resulting from Interactions between Tumors and Their Syngeneic HostsCurrent Employment: Vice Pres Preclin and Prod Develop, Powderject Vaccines Inc, Madison, Wisconsin

• SCHMITT, Mary Kay Plantin, Ph.D. in Experimental Pathology, 1982Thesis title: Tumor Cell Heterogeneity and Host Modulation of Tumor PhenotypeCurrent Employment: Professor Emeritus, Dept. of Biology, University of Alaska

• GURISH, Michael, Ph.D. in Experimental Pathology, 1982Thesis title: The Immunoregulatory Effects of Ultraviolet Exposure: Early EventsCurrent Employment: Assistant Professor, Harvard Medical School

• SPANGRUDE, Gerald, Ph.D. in Experimental Pathology, 1984Thesis title: Studies on the Molecular Mechanisms of Lymphocyte ExtravasationCurrent Employment: Associate Professor, Departments of Oncological Sciences and Internal Medicine, University of Utah

• GAHRING, Lorise, Ph.D. in Experimental Pathology, 1986Thesis title: The Effects of Ultraviolet Radiation on the Production of Epidermal-Derived Thymocyte Activating Factor / Interleukin-1Current Employment: Associate Professor, Department of Medicine, Univ of Utah

• HUANG, Kun, Ph.D. in Experimental Pathology, 1990Thesis title: Effects of Cellular Activation on Lymphocyte RecirculationCurrent Employment: Senior Scientist, Xoma Corp., San Francisco, CA

• EDELMAN, Linda, R.N., M.Phil. in Experimental Pathology, 1993Current Employment: Research Coordinator, Intermountain Burn Trauma Center, Department of Surgery, University of Utah

• HENNEBOLD, Jon, Ph.D. in Experimental Pathology, 1996Thesis title: Regulation of Steroid Hormone Action in Lymphoid OrgansCurrent Employment: Assistant Professor, Primate Research Center, Oregon Health Sciences University

• SPENCER, Nina L., Ph.D. in Experimental Pathology, 1997Thesis title: The Dysregulation of Cytokine Production with AgingCurrent Employment: Full-time parent

• CHEN, Xiao Ping, Ph.D. in Experimental Pathology, 1997Thesis title: Regulation of T Cell IL-4 Production by Neu-1 Sialidase and Ganglioside GM3Current Employment: Research Assistant Professor, University of Pittsburgh School of Medicine

• POYNTER, Matthew E., Ph.D. in Experimental Pathology, 1998


Thesis title: A Novel Mechanism for Modulation of Immune Function in Aging: Activation of PPARCurrent Employment: Research Assistant Professor, Department of Medicine, University of Vermont

• ZHOU, Hui, M. Phil. in Experimental Pathology, 1999Current Employment: Laboratory Technician at Cold Spring Harbor, NY

• MANNING, Bernadette, Ph.D. in Experimental Pathology, 2001Thesis title: Aging: New PPARadigms and Novel Strategies for Restoration of ImmunocompetenceCurrent Employment: Technology Transfer Office, USC

• LIU, Qing, M.S. in Medical Laboratory Science, 2002Thesis title: Effect of Aging on the Phenotype and Function of Bone Marrow Derived Dendritic Cells from BALB/c Mice.Current Employment: Laboratory Technician, ARUP, Salt Lake City, UT

• JONES, Dallas C., Ph.D. in Experimental Pathology, 2003 Thesis title: Defining a novel role for the nuclear hormone receptor PPARa in T-cell biology.Current Employment: Postdoctoral Fellow, Harvard

• ZHANG, Tian Yi (expected to graduate in 2006) Thesis research is on the characterization of the expression, regulation and immunobiologic functions of T-lymphocyte-associated 11-hydroxysteroid dehydrogenase I

Postdoctoral Fellows Supervised:• LYNCH, David, Ph.D., 1979-1982

Current Employment: Senior Research Scientist / Immunex Corp., Seattle, Washington• BEESON, James, M.D., Ph.D., 1980-1982

Current Employment: Professor and Chair, Department of OB-GYN, University of Oklahoma Medical School, Tulsa

• YOWELL, Robert, M.D., Ph.D., 1982-1983Current Employment: Pathologist, LDS Hospital, Salt Lake City, Utah

• CHUNG, Hun-Taeg, M.D. Ph.D., 1985-1987Current Employment: Professor and Chair, Department of Microbiology and Immunology, Wonkwang University Medical School, Korea

• KIM, Uh-Hyun, M.D., Ph.D., 1986-1987Current Employment: Professor and Chair, Department of Biochemistry, Chonbuk National University Medical School, Korea

• SAMLOWSKI, Wolfram, M.D., 1982-1987Current Employment: Professor, Division of Hematology/Oncology, Department of Internal Medicine, University of Utah

• CHO, Baik Hwan, M.D., 1986-1987Current Employment: Professor and Chair, Department of Surgery, Chonbuk

National University Hospital, Korea• LEE, Dong-Geum, M.D., 1987-1988

Current Employment: Professor, Pathology Department, Chonbuk National University Medical School, Korea• BURNHAM, D. Kim, Ph.D., 1984-1988

Current Employment: Associate Professor, Department of Microbiology, Oklahoma State University-Stillwater

• IM, Suhn-Young, Ph.D., 1987-1989 & 1996Current Employment: Associate Professor, Department of Microbiology, Natural Sciences, Chonnam National University, Kwangju, Korea

• MOON, Hyung Bae, Ph.D., 1988-1989


Current Employment: Professor, Pathology Department, Wonkwang University, Seoul, Korea

• HAN, Du-Seok, M.D., 1988-1989Current Employment: Professor, Anatomy Department, School of Dentistry, Wonkwang University, Seoul, Korea

• BEIGI, Maryam, M.D., 1988-1990Current Employment: Private Medical Practice, Tarzana, California

• TERUI, Tadashi, M.D., 1988-1991Current Employment: Associate Professor, Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan

• WIEDMEIER, Susan, M.D., 1984-1991Current Employment: Neonatologist, Private practice, Boise, Idaho

• YOSHIOKA, Akira, M.D., 1989-1991Current Employment: Assistant Professor, Department of Dermatology, Kyoto University, Kyoto, Japan

• LI, Gang-Zhou, M.D., 1989-1994Current Employment: Research Specialist, E-Bioscience, San Diego, CA

• ENIOUTINA, Elena, Ph.D., 1992-1996Current Employment: Research Assistant Professor, Department of Pathology

University of Utah• KIM, Sung-Ho, D.V.M., Ph.D., 1993-1994

Current Employment: Senior Researcher, Lab. Radiation Med., Korea Cancer Center Hospital

• MU, Hong-Hua, Ph.D., 1993-1996Current Employment: Research Associate Professor, Department of Internal

Medicine, University of Utah• RYU, Si-Yun, D.V.M., Ph.D., 1992, 1995-1996

Current Employment: Associate Professor, Department of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Korea

• HENNEBOLD, Jon, Ph.D., 1996-1997Current Employment: Assistant Professor, Primate Research Center, Oregon Health

Sciences University

New courses developed (over the last 6 years): Nuclear Hormone Receptor Function

BIBLIOGRAPHYOriginal publications:1. Daynes, R.A. and C. H. Armstrong. (1973) An antiphagocytic factor associated with Group

E Streptococcus. Infection and Immunity, 7:298.2. Hessinger, D.A., R.A. Daynes and G.A. Granger. (1973) The binding of human

lymphotoxin to target cell membranes and its relation to cell mediated cytodestruction. Proc. Natl. Acad. Sci., USA, 70:3082.

3. Daynes, R.A. and G.A. Granger. (1974) The regulation of lymphotoxin release from stimulated human lymphocyte cultures: The requirement for continual mitogen stimulation. Cellular Immunol., 12:252.

4. Spofford, B.T., R.A. Daynes and G.A. Granger. (1974) Cell mediated immunity in vitro: New, highly sensitive assays for human lymphotoxin. J. Immunol., 112:2111.

5. Granger, G.A., R.A. Daynes, P.E. Runge, A.M. Prieur and E.W. B. Jeffes. (1975) Lymphocyte effector molecules and cell-mediated immune reactions. Contemporary Topics in Molecular Immunology, 4:205.

6. Daynes, R.A., M.L. Thomas, V.L. Alvarex and L.B. Sandberg. (1977) The antigenicity of soluble porcine elastins: I. Measurement of antibody activity by a radioimmunoassay. Connective Tissue Research, 5:75.

7. Daynes, R.A., C.W. Spellman, J.G. Woodward and D.A. Stewart. (1977) Studies into the transplantation biology of ultraviolet-light induced tumors. Transplantation, 23:343-348.


8. Spellman, C.W., J.G. Woodward and R.A. Daynes. (1977) Modification of immunological potential by ultraviolet radiation. I. Immune status of short-term UV-irradiated mice. Transplantation, 24:112-119.

9. Daynes, R.A. and C.W. Spellman. (1977) Evidence for the generation of suppressor cells by ultraviolet radiation. Cellular Immunol., 31:182-187.

10. Spellman, C.W. and R.A. Daynes. (1977) Modification of immunological potential by ultraviolet light. II. Generation of suppressor cells in short-term UV-irradiation mice. Transplantation, 24:120-126.

11. Spellman, C.W. and R.A. Daynes. (1978) Immunoregulation by ultraviolet light. III. Enhancement of suppressor cell activity in older animals. Experimental Gerontology, 13:141-146.

12. Spellman, C.W. and R.A. Daynes. (1978) Properties of ultraviolet light induced tumors within a syngeneic tumor system. Cellular Immunol., 36:383-387.

13. Spellman, C.W. and R.A. Daynes. (1978) Ultraviolet light induced murine suppressor lymphocytes dictate specificity of anti-UV-tumor immune response. Cellular Immunol., 38:25-34.

14. Nichols, W.K., J.B. Spellman and R.A. Daynes. (1978) Immune responses of diabetic animals. Diabetologia, 14:343-349.

15. Woodward, J.G. and R.A. Daynes. (1978) Cell mediated immune response to syngeneic UV induced tumors. I. The presence of tumor associated macrophages and their possible role in the in vitro generation of cytotoxin lymphocytes. Cellular Immunol., 41:304-319.

16. Nichols, W.K., J.B. Spellman, L.L. Vann and R.A. Daynes. (1979) Immune responses of diabetic animals: Direct immunosuppressant effects of streptozotocin in mice. Diabetologia, 16:51-57.

17. Daynes, R.A., C.C. Harris, R.J. Connor and E.J. Eichwald. (1979) Skin cancer development in mice exposed chronically to immunosuppressive agents. J.N.C.I., 62(4):1075-1081.

18. Roberts, L.K., M.K. Schmitt and R.A. Daynes. (1979) Tumor susceptibility generated in mice treated with subcarcinogenic doses of 8-methoxypsoralen and long wave ultraviolet light. J. Invest. Dermatol., 72:306-309.

19. Daynes, R.A., P.A. Fernandez and J.G. Woodward. (1979) Cell mediated immune response to syngeneic UV-induced tumors. II. Properties and antigenic specificities of cytotoxic T-lymphocytes generated in vitro following removal from syngeneic tumor-immunized mice. Cellular Immunol., 45:398-414.

20. Woodward, J.G., P.A. Fernandez and R.A. Daynes. (1979) Cell mediated immune response to syngeneic UV-induced tumors. III. Requirement for an Ia+ macrophage in the in vitro differentiation of cytotoxic T-lymphocytes. J. Immunol., 122:1196-1202.

21. Daynes, R.A., M.K. Schmitt, L.K. Roberts and C.W. Spellman. (1979) Phenotypic and physical characteristics of the lymphoid cells involved in the immunity to syngeneic UV-induced tumors. J. Immunol., 122:2458-2464.

22. Woodward, J.G. and R.A. Daynes. (1979) Cell mediated immune response to syngeneic UV-induced tumors. IV. The presence of I-A and I-E coded antigens on the accessory cell required for the in vitro differentiation of cytotoxic T-lymphocytes. J. Immunol., 123:1227-1231.

23. Roberts, L.K. and R.A. Daynes. (1980) Modification of the immunologic properties of chemically induced tumors arising in hosts possessing a pre-existing enhanced tumor specific suppressor T-lymphocytes function. J. Immunol., 125:438-447.

24. Roberts, L.K., C.W. Spellman and R.A. Daynes. (1980) Modulation of immunoregulatory responses directed against various tumor antigens within hosts possessing distinct immunological potentials. J. Immunol., 125:663-672.

25. Spellman, C.W. and R.A. Daynes. (1981) Ultraviolet light, tumors and suppressor T-cells. Human Pathology, 12:299-301.

26. Lynch, D.H., M.F. Gurish and R.A. Daynes. (1981) Relationship between epidermal Langerhans cell density, ATPase activity and the induction of contact hypersensitivity. A possible mechanism for the induction of tumor susceptibility by ultraviolet light. J. Immunol., 126:1892-1897.


27. Gurish, M.F., L.K. Roberts, G.G. Krueger and R.A. Daynes. (1981) The effect of various sunscreen agents on skin damage and the induction of tumor susceptibility in mice subjected to chronic ultraviolet irradiation. J. Invest. Dermatol., 76:246-251.

28. Lynch, D.H., M.F. Gurish and R.A. Daynes. (1981) The effects of ultraviolet irradiation on the generation of anti-tumor cytotoxic effector cell responses in vitro. J. Immunol., 127:1163-1168.

29. Schmitt, M.K. and R.A. Daynes. (1981) Heterogeneity of tumorigenicity phenotype in murine tumors. I. Characterization of regressor and progressor clones isolated from a nonmutagenized UV regressor tumor. J. Exp. Med., 153:1344-1359.

30. Cole, B.C., R.A. Daynes and J.R. Ward. (1981) Mycoplasma-mediated activation of normal mouse lymphocytes: Induction of cytotoxic lymphocytes and lymphocyte transformation by Mycoplasma arthritidis are under Ir gene control. J. Immunol., 126:922-927.

31. Daynes, R.A., E.J. Bernhard, M.F. Gurish and D.H. Lynch. (1981) Experimental photoimmunology: Immunologic ramifications of UV-induced carcinogenesis. J. Invest. Dermatol., 77:77-85.

32. Cole, B.C., R.A. Daynes and J.R. Ward. (1981) Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. I. Transformation is under Ir gene control and is associated with the presence of Ia7 coded by the IE subregion. J. Immunol., 127:1931-1936.

33. Wagner, J.E. and R.A. Daynes. (1981) Observations of an outbreak of mousepox in laboratory mice in 1979 at the University of Utah Medical Center, U.S.A., Lab. Animal Sci., 31 (part II).

34. Schmitt, M. and R.A. Daynes. (1982) Heterogeneity of tumorigenicity phenotype in murine tumors. Characterization of tumor clones isolated from primary 3-methylcholanthrene-induced fibrosarcomas. Transplantation, 33:387-392.

35. Cole, B.C., G.J. Sullivan, R.A. Daynes and J.R. Ward. (1982) Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. II. Cellular requirements for T-cell transformation mediated by a soluble mycoplasma mitogen. J. Immunol., 128:2013-2018.

36. Gurish, M.F., D.H. Lynch and R.A. Daynes. (1982) Changes in antigen presenting cell function in the spleen and lymph nodes of UV-irradiated mice. Transplantation, 33(3):280-284.

37. Roberts, L.K., D.H. Lynch and R.A. Daynes. (1982) Evidence for two functionally distinct cross-reactive tumor antigens associated with ultraviolet light and chemically induced tumors. Transplantation, 33(4):352-360.

38. Lynch, D.H., M.F. Gurish and R.A. Daynes. (1982) Cell-mediated immune responses to syngeneic UV-induced tumors. V. Assessment of accessory and antigen presenting cell capabilities of normal and UV-irradiated mice in the generation of anti-tumor cytotoxic effector cells in vitro. Immunol., 47:49-59.

39. Roberts, L.K. and R.A. Daynes. (1982) Puva-induced UVB-tumor susceptibility. J. Invest. Dermatol. (Letter to the Editor), 79(1):63.

40. Cole, B.C., R.A. Daynes and J.R. Ward. (1982) Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. III. Ir gene control of lymphocyte transformation correlates with binding of the mitogen to specific Ia-bearing cells. J. Immunol., 129(4):1352-1359.

41. Daynes, R.A., J.M. Novak and B.C. Cole. (1982) Comparison of the cellular requirements for human T-cell transformation by a soluble mitogen derived from Mycoplasma arthritidis and concanavalin A. J. Immunol., 129(3):936-938.

42. Spangrude, G.J., D. Sherris and R.A. Daynes. (1982) Inhibitory effects of various oxygenated sterols on the differentiation and function of tumor-specific cytotoxic T lymphocytes. Transplantation, 33(5):482-491.

43. Schmitt, M., L.K. Roberts, L.C. Gahring and R.A. Daynes. (1983) Enhanced tumorigenicity of cloned UV-regressor tumor lines following selected in vivo and in vitro manipulations. Am. J. Path., 113:269-278.

44. Daynes, R.A., M. Emam, G.G. Krueger and L.K. Roberts. (1983) Expression of Ia antigen on epidermal keratinocytes following the grafting of normal skin to nude mice. J. Immunol., 130(4):1536-1539.


45. Beeson, J.H., J.R. Scott and R.A. Daynes. (1983) The presence of oncofetal antigens on ultraviolet light and methylcholanthrene-induced murine tumors which are common to placental and fetal tissues. Am. J. Reproductive Immunol., 3:92-96.

46. Gurish, M.F., D.H. Lynch, R. Yowell and R.A. Daynes. (1983) Abrogation of epidermal antigen presenting cell function by ultraviolet radiation administered in vivo. Transplantation, 36(3):304-309.

47. Krueger, G.G., R.A. Daynes and M. Emam. (1983) Biology of Langerhans cells: Selective migration of Langerhans cells into allogeneic and xenogeneic grafts on nude mice. P.N.A.S., 80:1650-1654.

48. Lynch, D.H. and R.A. Daynes. (1983) Evaluation of naturally-occurring cell mediated cytotoxic activity in normal and UV-irradiated mice. Transplantation, 35(3):216-223.

49. Spangrude, G.J., E.J. Bernhard, R.S. Ajioka and R.A. Daynes. (1983) Alterations in lymphocyte homing patterns within mice exposed to ultraviolet radiation. J. Immunol., 130(6):2974-2981.

50. Lynch, D.H., M.F. Gurish, B.C. Cole and R.A. Daynes. (1983) T-cell proliferation responses to a mitogen derived from Mycoplasma arthritidis are controlled by the accessory cell. J. Immunol., 131(4):1702-1706.

51. Lynch, D.H., M.F. Gurish and R.A. Daynes. (1983) The effects of high dose UV-exposure on murine Langerhans cell function at exposed and unexposed sites as assessed using in vivo and in vitro assays. J. Invest. Dermatol., 81:336-341.

52. Piepkorn, M.W. and R.A. Daynes. (1983) Heparin effect on DNA synthesis in a murine fibrosarcoma line: Influence of anionic density. J.N.C.I., 71:615-618.

53. Yowell, R.L., B.C. Cole and R.A. Daynes. (1983) Utilization of T-cell hybridomas to establish that a soluble factor derived from Mycoplasma arthritidis is truly a genetically restricted polyclonal T-cell activator. J. Immunol., 131:543-545.

54. Gahring, L., M. Baltz, M.B. Pepys and R.A. Daynes. (1984) The effect of ultraviolet radiation on the production of ETAF/IL-1 in vivo and in vitro. P.N.A.S. 81:1198-1202.

55. Spangrude, G.J., B.A. Braaten and R.A. Daynes. (1984) Molecular mechanisms of lymphocyte extravasation. I. Studies on two selective inhibitors of lymphocyte recirculation. J. Immunol., 132:354-362.

56. Roberts, L.K., E.J. Bernhard and R.A. Daynes. (1984) Experimental ultraviolet radiation carcinogenesis: I. The relationship of skin pigmentation and major histocompatibility complex to tumor latency and immunogenicity. J. Photoderm., 1:57-64.

57. Braaten, B.A., G.J. Spangrude and R.A. Daynes. (1984) Molecular mechanisms of lymphocyte extravasation. II. Studies of in vitro lymphocyte adherence to high endothelial venules. J. Immunol., 133:117-122.

58. Samlowski, W.E., G.J. Spangrude and R.A. Daynes. (1984) Studies on the liver sequestration of lymphocytes bearing membrane associated galactose terminal glycoconjugates: Reversal with agents that effectively compete for the asialoglycoprotein receptor. Cell. Immunol., 88:309-322.

59. Beeson, J.H., R.A. Daynes, A.M. Weinert, Jr. and L.C. Gahring. (1984) Tumors arising from injection of cultured murine placental cells into normal animals: Direct evidence for placental origin of tumors of two histologic types. J.N.C.I., 73:705-709.

60. Daynes, R.A., S.P. Sholly, L.C. Gahring and G.J. Spangrude. (1984) The skin: The primary immunologic organ involved in burn injury. J. Trauma 24:584.

61. Spellman, C.W. and R.A. Daynes. (1984) Cross reactive antigens between ultraviolet radiation induced tumors and UVR-exposed skin. Photodermatology 1:164-169.

62. Daynes, R.A., G.J. Spangrude, L.K. Roberts and G.G. Krueger. (1985) Regulation by the skin of lymphoid cell recirculation and localization properties. J. Invest. Dermatol., 85:14s-20s.

63. Spangrude, G.J., B.A. Araneo and R.A. Daynes. (1985) Site-selective homing of antigen primed lymphocyte populations can play a crucial role in the efferent limb of cell-mediated immune responses in vivo. J. Immunol., 134:2900-2907.

64. Spangrude, G.J., F. Sacchi, H.R. Hill, D.E. Van Epps and R.A. Daynes. (1985) Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin. J. Immunol., 135:4135-4143.


65. Roberts, L.K., G.G. Krueger and R.A. Daynes. (1985) Correlation between the inducible keratinocyte expression of Ia and the movement of Langerhans cells into the epidermis. J. Immunol., 134:3781-3784.

66. Samlowski, W.E., B.A. Braaten and R.A. Daynes. (1985) Characterization of the in vitro interaction of PNAhi lymphocytes with the bone marrow and hepatic asialoglycoprotein receptors. Cell. Immunol., 95:1-14.

67. Daynes, R.A., D.K. Burnham, C.W. DeWitt, L.K. Roberts and G.G. Krueger. (1985) The immunobiology of UVR-carcinogenesis. Cancer Surveys 4(1):51-99.

68. Samlowski, W.E. and R.A. Daynes. (1985) Bone marrow engraftment efficiency is enhanced by competitive inhibition of the asialoglycoprotein receptor. P.N.A.S., 82:2508-2512.

69. Gahring, L.C., A. Buckley and R.A. Daynes. (1985) The presence of epidermal derived thymocytes in activating factor/interleukin-1 in normal human stratum corneum. J. Clin. Invest., 76:1585-1591.

70. Roberts, L.K., G.J. Spangrude, R.A. Daynes and G.G. Krueger. (1985) Correlation between keratinocyte expression of Ia and the intensity and duration of contact hypersensitivity responses in mice. J. Immunol., 135:2929-2936.

71. Burnham, D.K., L.C. Gahring and R.A. Daynes. (1986) Clonal origin of tumors induced by ultraviolet radiation. J. Natl. Cancer Inst., 76:151-158.

72. Gahring, L.C. and R.A. Daynes. (1986) Desensitization of animals to the inflammatory effects of ultraviolet radiation is mediated through mechanisms which are distinct from those responsible for endotoxin tolerance. J. Immunol., 136:2868-2874.

73. Lynch, D.H., R.A. Daynes and R.J. Hodes. (1986) Cell-mediated immune responses to syngeneic tumors. I. Identification of two distinct CTL effector pathways which differ in antigen specificity , genetic regulation, and cell-surface phenotype. J. Immunol., 136:1521-1527.

74. Chung, H-T., W. Samlowski and R.A. Daynes. (1986) Modification of the murine immune system by glucocorticosteroids: Alterations of the tissue localization properties of circulating lymphocytes. Cellular Immunol., 101:571-585.

75. Robertson, B.A., L.C. Gahring and R.A. Daynes. (1986) Neuropeptide regulation of interleukin-1 activities: Capacity of -melanocyte stimulating hormone to inhibit interleukin-1 inducible responses in vivo and in vitro exhibits target cell selectivity. Inflammation. 10:371-385.

76. Roberts, L.K., W.E. Samlowski and R.A. Daynes. (1986) Immunological consequences of ultraviolet radiation exposure. Photodermatology 3:284-297.

77. Chung, H-T., D.K. Burnham, B. Robertson, L.K. Roberts and R.A. Daynes. (1986) Involvement of prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation. J. Immunol., 137:2478-2484.

78. Chung, H-T., W.E. Samlowski, D.E. Kelsey and R.A. Daynes. (1986) Alterations in lymphocyte recirculation with ultraviolet-light irradiated mice: Efferent blockade of lymphocyte egress from peripheral lymph nodes. Cell. Immunol., 102:335-345.

79. Daynes, R.A., H-T. Chung and L. Roberts. (1986) Photoimmunology - Past, Present and Future. J. Korean Soc. Microbiol., 21(3):1.

80. Samlowski, E.W., J.M. Johnson, E.H. Hammond, B.A. Robertson and R.A. Daynes. (1987) Marrow ablative doses of gamma-irradiation cause protracted changes in the peripheral lymph node microvasculature of murine and human bone marrow transplant recipients. Lab. Invest., 56:85-95.

81. Wiedmeier, S.E., D.K. Burnham, U. Singh and R.A. Daynes. (1987) Implantation of thymic epithelial grafts into the anterior chamber of the murine eye: An experimental model for analyzing T-cell ontogeny. Thymus 9:25-44.

82. Robertson, B., L. Gahring and R.A. Daynes. (1987) In vivo administration of interleukin-1 to normal mice depresses their capacity to elicit contact hypersensitivity responses: Prostaglandins are involved in this immune depression. J. Invest. Dermatol. 88:380-387.

83. Daynes, R.A., B.A. Robertson, B.H. Cho, D.K. Burnham and R. Newton. (1987) -Melanocyte stimulating hormone exhibits target cell selectivity in its capacity to affect Interleukin-1 inducible responses in vivo and in vitro. J. Immunol., 139:103-109.


84. Servilla, K.S., D.K. Burnham and R.A. Daynes. (1987) Treatment of mice with Cyclosporine A is capable of promoting the growth of transplanted ultraviolet radiation induced tumors. Transplantation 44:291-295.

85. Wiedmeier, S.E., H-T. Chung, B.H. Cho, U-H. Kim and R.A. Daynes. (1987) Murine responses to immunization with pertussis toxins and bovine serum albumin. I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction. Pediatric Res. 22:262-267.

86. Lynch, D.H., L.K. Roberts and R.A. Daynes. (1987) Skin Immunology - The Achilles Heel to Transdermal Drug Delivery? J. of Controlled Release, 6:39-50.

87. Wiedmeier, S.E., W.E. Samlowski, C.J. Rasmussen, K. Huang and R.A. Daynes. (1988) Effect of ionizing radiation on thymic epithelial cell function. I. Radiation-spared thymic epithelial grafts expedite the recovery of T-cell function in lethally irradiated and fetal liver reconstituted mice. J. Immunol., 140:21-29.

88. Jun, B.D., L. Roberts, B.H. Cho, B. Robertson and R.A. Daynes. (1988) Parallel recovery of epidermal antigen-presenting cell activity and contact hypersensitivity responses in mice exposed to ultraviolet irradiation: The role of a prostaglandin dependent mechanism. J. Invest. Dermatol., 90:311-316.

89. Kim, U-H., H-R. Kim, S.F. Rockwood and R.A. Daynes. (1988) Membrane associated nicotinamide adenine dinucleotide glycohydrolase from rabbit erythrocytes is solubilized by phosphatidylinositol-specific phospholipase C. Biochem. Biophys. ACTA, 965:76-81.

90. Robertson, B., K. Dostal and R.A. Daynes. (1988) Neuropeptide regulation of immunologic and inflammatory responses. Capacity of -melanocyte stimulating hormone to inhibit tumor necrosis factor and interleukin-1-inducible biological responses. J. Immunol., 140:4300-4307.

91. Samlowski, W.E., H-T. Chung, D.K. Burnham and R.A. Daynes. (1988) The role of macrophages in the regulation of high endothelial venule expression within the peripheral lymph nodes of mice exposed to ultraviolet radiation. Reg. Immunol. 1:41-55.

92. Lee, D-G., B.H. Cho, J. Hervey and R.A. Daynes. (1988) The role of neutrophils in tissue localized cell-mediated immunologic responses: I. The intensity of contact-type and delayed-type hypersensitivity responses may be due to the extent of extracellular matrix degradation by neutrophil proteases. Reg. Immunol., 1:149-162.

93. Samlowski, W.E., J. Shelby, B.A. Robertson and R.A. Daynes. (1989) Depression of the induction of murine delayed-type hypersensitivity responses without prolongation of cardiac allograft survival by intravenous neuraminidase-treated allogeneic lymphocytes. Transplantation 47:560-564.

94. Burnham, D.K., C.K. Mak, R.J. Webster and R.A. Daynes. (1989) Relationship between inducible H-2 expression and the immunogenicity of murine skin neoplasms. I. Evidence that the immunogenicity of ultraviolet radiation-induced tumors is associated with their susceptibility to -interferon-mediated enhancement of H-2Kk. Transplantation 47:533-542.

95. Huang, K, S-Y. Im, W.E. Samlowski and R.A. Daynes. (1989) Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C. J. Immunol. 143:229-238.

96. Araneo, B.A., R. Dowell, H.B. Moon and R.A. Daynes. (1989) Regulation of murine lymphokine production in vivo: UVR exposure depresses IL-2 and enhances IL-4 production by T cells through an IL-1-dependent mechanism. J. Immunol. 143:1737-1744.

97. Im, S-Y., S.E. Wiedmeier, B-H. Cho, D.G. Lee, M. Beigi and R.A. Daynes. (1989) Dual effects of pertussis toxin on murine neutrophils in vivo. I. Pertussis toxin inhibits the extravasation potential of mature neutrophils while simultaneously stimulating granulopoiesis. Inflammation 13:707-726.

98. Jun, B-D., M.Y.L. Law, R.A. Daynes and L.K. Roberts. (1989) Splenic contribution to the recovery of ATPase/Ia+ epidermal cells in the skin of mice after exposure to ultraviolet radiation. Reg. Immunol. 2:225-235.


99. Daynes, R.A. and B.A. Araneo. (1989) Contrasting effects of glucocorticosteroids on the capacity of T cells to produce the growth factors IL-2 and IL-4. Eur. J. Immunol. 19:2319-2325.

100. Daynes, R.A., B.A. Araneo, T.A. Dowell, K Huang and D. Dudley. (1990) Regulation of murine lymphokine production in vivo: III. The lymphoid tissue microenvironment exerts regulatory influences over T-helper cell function. J. Exp. Med. 171:979-996.

101. Daynes, R.A., D.J. Dudley and B.A. Araneo. (1990) Regulation of murine lymphokine production in vivo: II. Dehydroepiandrosterone is a natural enhancer of IL-2 synthesis by helper T cells. Eur. J. Immunol. 20:793-802.

102. Steen, P.D., E.R. Ashwood, K. Huang, R.A. Daynes, H-T. Chung and W.E. Samlowski. (1990) Mechanisms of pertussis toxin inhibition of lymphocyte-HEV interactions: I. Analysis of lymphocyte homing receptor-mediated binding mechanisms. Cell. Immunol. 131:67-85.

103. Huang, K., M. Beigi and R.A. Daynes. (1990) Peripheral lymph node-specific and Peyer's patch-specific homing receptors are differentially regulated following lymphocyte activation. Reg. Immunol. 3:103-111.

104. Branch, D.W., D. J. Dudley, M.D. Mitchell, K. A. Creighton, T.M. Abbott, E.H. Hammond and R.A. Daynes. (1990) IgG fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: A model for autoimmune fetal loss. Am. J. Ob-Gyn. 163:210-216.

105. Daynes, R.A., A.W. Meikle and B.A. Araneo. (1991) Locally active steroid hormones may facilitate compartmentalization of immunity by regulating the types of lymphokines produced by helper T cells. Research in Immunology 142:40-45.

106. Wiedmeier, S.E., B.A. Araneo, K. Huang and R.A. Daynes. (1991) Thymic modulation of IL-2 and IL-4 synthesis by peripheral T cells. Cell. Immunol. 135:501-518.

107. Mitchell, M.D., D. Ware Branch, S. Lundin-Schiller, R.J. Romero, R.A. Daynes and D.J. Dudley. (1991) Immunologic aspects of preterm labor. Seminars in Perinatology, 15:210-224.

108. Araneo, B.A., T. Dowell, T. Terui, M. Diegel and R.A. Daynes. (1991) Dihydrotestosterone exerts a depressive influence on the production of IL-4, IL-5, and IFN, but not IL-2 by activated murine cells. Blood 78:688-699.

109. Morrey, J.D., S.M. Bourn, T.D. Bunch, M.K. Jackson, R.W. Sidwell, L.R. Barrows, R.A. Daynes and C.A. Rosen. (1991) In vivo activation of HIV-1 long terminal repeat by ultraviolet type-B (UV-B) and psoralen-dependent UV-A light in the skin of transgenic mice. J. Virology 65:5045-5051.

110. Suzuki, T., N. Suzuki, R.A. Daynes and E.G. Engleman. (1991) Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells. Clin. Immunol. Immunopath. 61:202-211.

111. Daynes, R.A., T. Dowell and B.A. Araneo. (1991) Platelet derived growth factor is a potent biologic response modifier of T cells. J. Exp. Med. 174:1323-1334.

112. Meikle, A.W., R.W. Dorchuck, B.A. Araneo, J.D. Stringham, T.G. Evans, S.L. Spruance and R.A. Daynes. (1992) The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells. J. Steroid Biochem. Molec. Biol. 42:293-304.

113. Daynes, R.A. and B.A. Araneo. (1992) Programming of lymphocyte responses to activation: Extrinsic factors, provided microenvironmentally, confer flexibility and compartmentalization to T-cell function. Chem. Immunol. 54:1-20.

114. Daynes, R.A. and B.A. Araneo. (1992) Prevention and reversal of age-associated changes in immunologic responses by supplemental dehydroepiandrosterone sulfate therapy. Aging: Immunol. Infect. Dis. 3:135-154.


115. Daynes, R.A. and B.A. Araneo. (1992) Natural regulators of T-cell lymphokine production in vivo. J. Immunotherapy 12:174-179.

116. Araneo, B.A., J. Shelby, G-Z. Li, W. Ku and R.A. Daynes. (1993) Administration of DHEA to burned mice preserves normal immunologic competence. Arch. Surg. 128:318-325.

117. Araneo, B.A., M.L. Woods, II, and R.A. Daynes. (1993) Reversal of the immunosenescent phenotype by dehydroepiandrosterone: Hormone treatment provides an adjuvant effect on the immunization of aged mice with recombinant hepatitis B surface antigen. J. Infect. Dis. 167:830-840.

118. Daynes, R.A., B.A. Araneo, W.B. Ershler, C.D. Maloney, G-Z. Li, and S-Y. Ryu. (1993) Altered regulation of IL-6 production with normal aging: Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J. Immunol. 150(12):5219-5230.

119. Dudley, D.J., C.L. Chen, M.D. Mitchell, R.A. Daynes and B.A. Araneo. (1993) Adaptive immune responses during murine pregnancy: Pregnancy-induced regulation of lymphokine production by activated T lymphocytes. Am. J. Obstet. Gynecol. 168(4):1155-1163.

120. Ershler, W.B., W.H. Sun, N. Binkley, S. Gravenstein, M.J. Volk, G. Kamoske, R.G. Klopp, E.B. Roecker, R.A. Daynes, and R. Weindruch. (1993) Interleukin-6 and Aging: Blood Levels and Mononuclear Cell Production Increase with Advancing Age and In Vitro Production Is Modifiable by Dietary Restriction. Lymphokine and Cytokine Res. 12(4):225-230.

121. Daynes, R.A. and B.A. Araneo. (1994) The development of effective vaccine adjuvants employing natural regulators of T-cell lymphokine production in vivo. Ann. N.Y. Acad. Sci. 730:144-161.

122. Wiedmeier, S.E., H-H. Mu, B.A. Araneo and R.A. Daynes. (1994) Age and Microenvironment-Associated Influences by Platelet-Derived Growth Factor on T-cell Function. J. Immunol. 152:3417-3426.

123. Hennebold, J.D., R.A. Daynes. (1994) Regulation of Macrophage Dehydroepiandrosterone Sulfate Metabolism by Inflammatory Cytokines. Endocrinology 135(1):67-75.

124. Volk, M.J., T.D. Pugh, M-J. Kim, C.H. Frith, R.A. Daynes, W.B. Ershler and R. Weindruch. (1994) Dietary restriction from middle age attenuates age-associated lymphoma development and IL-6 dysregulation in C57BL/6 mice. Cancer Research 54:3054-3061.

125. Silver, R.M., W.S. Lohner, R.A. Daynes, M.D. Mitchell, D.W. Branch. (1994) Lipopolysaccharide-Induced Fetal Death: The Role of Tumor-Necrosis Factor Alpha. Biol. Reprod. 50:1108-1112.

126. Silver, R.M., Yang, L., Daynes, R.A., Branch, D.W., Salafia, C.M., and Weis, J.J. (1995) Fetal outcome in murine Lyme disease. Infection and Immunity 63:66-72.

127. Araneo, B.A. and R.A. Daynes. (1995) DHEA Functions as more than an Anti-glucocorticoid in Preserving Immunocompetence Following Thermal Injury. Endocrin. 136(3):393-401.

128. Araneo, B.A., S-Y. Ryu, S. Barton and R.A. Daynes. (1995) Dehydroepiandrosterone reduces progressive dermal ischemia caused by thermal injury. J. Surg. Res. 59:250-262.

129. Daynes, R.A., B.A. Araneo, J. Hennebold, E. Enioutina, H.H. Mu. (1995) Steroids as Regulators of the Mammalian Immune Response. J. Invest. Derm. 105:14S-19S.

130. Hennebold, J.D., M.E. Poynter, R.A. Daynes. (1995) DHEA and Immune Function: Activities and Mechanism of Action. Seminars in Reproductive Endocrinology 13(4):257-269.


131. Spruance, S.L., T.G. Evans, M.B. McKeough, L. Thai, B.A. Araneo, R.A. Daynes, E.M. Mishkin, A.S. Abramovitz. (1995) Th1/Th2-like immunity and resistance to herpes simplex labialis. Antiviral Research 28:39-55.

132. Spencer, N.F.L., M.E. Poynter, J.D. Hennebold, H-H. Mu, R.A. Daynes. (1995) Does DHEAS restore immune competence in aged animals through its capacity to function as a natural modulator of peroxisome activities? In: Dehydroepiandrosterone (DHEA) and Aging. Eds: F.L. Bellino, R.A. Daynes, P.J. Hornsby, D.H. Lavrin, J.E. Nestler. Ann. N.Y. Acad. Sci. 774:200-216.

133. Araneo, B.A., M.L. Woods, R.A. Daynes. (1995) DHEAS as an Effective Vaccine Adjuvant in Elderly Humans. In: Dehydroepiandrosterone (DHEA) and Aging. Eds: F.L. Bellino, R.A. Daynes, P.J. Hornsby, D.H. Lavrin, J.E. Nestler. Ann. N.Y. Acad. Sci. 774:232-248.

134. Kriesel, J.D., S.L. Spruance, R.A. Daynes, B.A. Araneo. (1996) Nucleic Acid Vaccine Encoding Glycoprotein gD2 Protects Mice from Herpes Simplex Virus Type 2 Disease. Journal of Infectious Diseases 173:536-541.

135. Daynes, R.A., E.Y. Enioutina, S. Butler, H-H. Mu, Z.A. McGee, B.A. Araneo. (1996) Induction of Common Mucosal Immunity by Hormonally Immunomodulated Peripheral Immunization. Infection and Immunity 64(4):1100-1109.

136. Spencer, N.F.L., S.D. Norton, L.L. Harrison, G-Z. Li, R.A. Daynes. (1996) Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative. Experimental Gerontology 31(3):393-408.

137. Hennebold, J.D., S-Y. Ryu, H-H. Mu, A. Galbraith, R.A. Daynes. (1996) 11-Hydroxysteroid Dehydrogenase Modulation of Glucocorticoid Activities in Lymphoid Organs. American Journal of Physiology 270:R10296-R10306.

138. Evans, T.G., M.E. Judd, T. Dowell, S. Poe, R.A. Daynes, B.A. Araneo. (1996) The Use of Oral Dehydroepiandrosterone Sulfate as an Adjuvant in Tetanus and Influenza Vaccination of the Elderly. Vaccine 14(16):1531-1537.

139. Hennebold, J.D., H-H. Mu, M. Poynter, X-P. Chen, R.A. Daynes. (1997) Active Catabolism of Glucocorticoids by 11-Hydroxysteroid Dehydrogenase In Vivo Is a Necessary Requirement for Natural Resistance to Infection with Listeria monocytogenes. International Immunology 9(1):105-115.

140. Chen, X-P., R.A. Daynes. (1997) The Control of IL-4 Gene Expression in Activated Murine T Lymphocytes: A Novel Role for neu-1 Sialidase. J. Immunol. 158:3070-3080.

141. Spencer, N.F.L. and R.A. Daynes. (1997) IL-12 Directly Stimulates Expression of IL-10 by CD5+ B Cells and IL-6 by Both CD5+ and CD5- B Cells: Possible Involvement in Age-associated Cytokine Dysregulation. International Immunology 9(5):745-754.

142. Poynter, M.E., H-H. Mu, X-P. Chen, and R.A. Daynes. (1997) Activation of NK1+ T Cells In Vitro and Their Possible Role in Age-associated Changes in Inducible IL-4 Production. Cellular Immunology 179: 22-29.

143. Spencer, N.F.L., M.E. Poynter, S-Y. Im, and R.A. Daynes. (1997) Constitutive Activation of NF-B in an Animal Model of Aging. International Immunology 9(10):1581-1588.

144. Gubarev, M.I., E.Y. Enioutina, J.L. Taylor, D.M. Visic, R.A. Daynes. (1998) Plant-derived glycoalkaloids protect mice against lethal infection with Salmonella typhimurium. Phytotherapy Research 12(2):79-88.

145. Hennebold, J.D. and R.A. Daynes. (1998) Inhibition of Skin 11-Hydroxysteroid Dehydrogenase Activity In Vivo Potentiates the Anti-inflammatory Actions of Glucocorticoids. Archives of Dermatological Research 290:413-419.

146. Poynter, M.E. and R.A. Daynes. (1998) PPAR Activation Modulates Cellular Redox Status, Represses NF-B Signaling, and Reduces Inflammatory Cytokine Production in Aging. The Journal of Biological Chemistry. 273(49):32833-32841.


147. Chiu, K.M., M.J. Schmidt, T.C. Havighurst, A.L. Shug, R.A. Daynes, E.T. Keller, and S. Gravenstein. (1999) Correlation of Serum L-Carnitine and Dehydro-epiandrosterone Sulphate Levels with Age and Sex in Healthy Adults. Age and Ageing 28:211-216.

148. Enioutina, E.Y., D. Visic, Z.A. McGee, and R.A. Daynes. (1999) The induction of systemic and common mucosal immune responses following the subcutaneous immunization of mature adult mice: Characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant. Vaccine 17(23-24):3050-3064.

149. Poynter, M.E. and R.A. Daynes. (1999) Age-Associated Alterations in Splenic iNOS Regulation: Influence of Constitutively-Expressed IFN- and Correction Following Supplementation with PPAR Activators or Vitamin E. Cellular Immunology 195(2):127-136.

150. Daynes, R.A., and J.A. Smith. (1999) Aging and Menopause: Targeting Strategies for Therapies. Clinical Geriatrics 7(9):56-65.

151. Enioutina, E.Y., D. Visic, and R.A. Daynes. (2000) Enhancement of Common Mucosal Immunity in Aged Mice Following Their Supplementation with Various Antioxidants. Vaccine 18(22):2381-2393.

152. Enioutina, E.Y., D. Visic, and R.A. Daynes. (2000) The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: Alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity. Vaccine 18(24):2753-2767.

153. Chen, X-P., X. Ding, and R.A. Daynes. (2000) Ganglioside Control Over IL-4 Priming and Type 2 Cytokine Production in Activated T Cells. Cytokines 12(7):972-985.

154. Heithoff, D.M., E.Y. Enioutina, R.A. Daynes, R.L. Sinsheimer, D.A. Low, and M.J. Mahan. (2001) Salmonella DNA Adenine Methylase Mutants Confer Cross-Protective Immunity. Infection and Immunity 69(11):6725-6730.

155. Manning, B.M., E.Y. Enioutina, D.M. Visic, A.D. Knudson, and R.A. Daynes. (2001) CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice. Exp Gerontol 37(1):107-126.

156. Jones, D.C., Ding, X., and R.A. Daynes. (2002) Nuclear Receptor PPAR is expressed in resting murine lymphocytes: The PPAR in T and B lymphocytes is both transactivation and transrepression competent. JBC 277(9):6838-6845.

157. Enioutina, E.Y., D.M. Visic, and R.A. Daynes. (2002) The induction of systemic and mucosal immunity to protein vaccines delivered through skin sites exposed to UVB. Vaccine 20(16):2116-2130.

158. Jones, D.C., B.M. Manning, and R.A. Daynes. (2002) A Role for the Peroxisome Proliferator Activated Receptor Alpha in T-cell Physiology and Ageing Immunobiology. Proceedings of the Nutrition Society 61(3):363-369.

159. Daynes, R.A., and D.C. Jones. (2002) Emerging Roles of Peroxisome Proliferator-Activated Receptors in Inflammation and Immunity. Nature Reviews Immunology 2(10):748-759.

160. Scaife, C.L., J. Kuang, J.C. Wills, D.B. Towbridge, P. Gray, B.M. Manning, E.J. Eichwald, R.A. Daynes, and S.K. Kuwada. (2002) Nuclear Factor B Inhibitors Induce Adhesion-dependent Colon Cancer Apoptosis: Implications for Metastasis. Cancer Research 62:6870-6878.

161. Jones, D.C., X. Ding, T.Y. Zhang, and R.A. Daynes. (2003) PPAR negatively regulates T-bet transcription through suppression of p38 MAP kinase activation. Journal of Immunology 171:196-203.

162. Daynes R.A., E.Y. Enioutina, and D.C. Jones. (2003) Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. Antioxidants and Redox Signaling 5(5):537-548.

163. Poynter, M.E., and R.A. Daynes. (2004) PPAR Activation: A Drink From the Fountain of Youth? The Biologist 51(1):27-31.

164. Zhang, T.Y., X. Ding, and R.A. Daynes. (2005) The Expression of 11-Hydroxysteriod Dehydrogenase Type I by Lymphocytes Provides a Novel Means for Intracrine Regulation of Glucocorticoid Activities. Journal of Immunology 174:879-889


165. Zhang, T.Y., R. A. Daynes. (2007) Glucocorticoid conditioning of myeloid progenitors enhances Toll-like receptor 4 signaling via negative regulation of the PI3K-Akt pathway. Journal of Immunology 178(4):2517-2526.

166. Enioutina, E.Y., Bareyan, D., R. A. Daynes. (2007) Vitamin D3-mediated alterations to myeloid dendritic cell trafficking in vivo expands the scope of their antigen presenting properties. Vaccine 25:1236-1249.

Books and Book Chapters:1. Woodward, J.G., C.W. Spellman and R.A. Daynes. (1977) Suppression of the immune

response to UV induced tumors by UV light. Regulatory mechanisms in lymphocyte activation. Proc. 11th Leukocyte Culture Conference. pp. 713-715.

2. Schmitt, M.K. and R.A. Daynes. (1983) Heterogeneity and variant induction in the progression of ultraviolet light induced tumors. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. II, pp. 25-36.

3. Gurish, M.F., D.H. Lynch, R.A. Daynes. (1983) Alterations in the activity of antigen presenting cells following exposure to ultraviolet light. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. II, pp. 51-59.

4. Lynch, D.H. and R.A. Daynes. (1983) Natural cell-mediated cytotoxic (NCMC) function in normal and UVL-exposed animals. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. II, pp. 61-69.

5. Lynch, D.H. and R.A. Daynes. (1983) In vitro modification of lymphocyte and macrophage functions following UVL exposure. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. II, pp. 71-88.

6. Spangrude, G.J. and R.A. Daynes. (1983) Oxygenated sterols as immunosuppressive agents. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. II, pp. 89-102.

7. Daynes, R.A., M.F. Gurish, D.H. Lynch and G.J. Spangrude. (1983) Biological consequences of acute and chronic UVR exposures. In: The Effect of Ultraviolet Radiation on the Immune System. (John A. Parrish, ed.) Johnson and Johnson Publication, pp. 209-228.

8. Spellman, C.W. and R.A. Daynes. (1983) Cross-reactive antigenicity between UVB irradiated skin and UVB induced tumors. In: The Effect of Ultraviolet Radiation on the Immune System. (John A. Parrish, ed.) Johnson and Johnson Publication, pp. 245-255.

9. Lynch, D.H. and R.A. Daynes. (1983) The effects of UV-radiation on natural cell-mediated cytotoxic activity. In: The Effect of Ultraviolet Radiation on the Immune System. (John A. Parrish, ed.) Johnson and Johnson Publication, pp. 301-316.

10. Krueger, G.G., R.A. Daynes, L.K. Roberts and M. Emam. (1984) Migration of Langerhans cells and the expression of Ia on epidermal cells following the grafting of normal skin to nude mice. In: Proc. 4th Int. Congress on Immunodeficient Animals, pp. 97-102.

11. Gahring, L.C. and R.A. Daynes. (1985) The presence of functionally active ETAF/IL-1 in normal human stratum corneum. Physiologic, Metabolic, and Immunologic Actions of Interleukin-1. pp. 375-384.

12. Spangrude, G.J., W.E. Samlowski and R.A. Daynes. (1986) Physical considerations in experimental photoimmunology. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. III, pp. 3-29.

13. Gahring, L.C., S.P. Sholly, D.N. Sauder and R.A. Daynes. (1986) A proposed central role for Interleukin-1 in the immunologic modifications of experimental animals to ultraviolet radiation. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. III, pp. 31-52.


14. Roberts, L.K. and R.A. Daynes. (1986) Active immunoregulation toward antigens expressed by ultraviolet radiation-induced tumors. In: Experimental and Clinical Photoimmunology. CRC Press, Florida, Vol. III, pp. 77-109.

15. Daynes, R.A., W.E. Samlowski, D.K. Burnham, L.C. Gahring and L.K. Roberts. (1986) Immunobiological consequences of acute and chronic UV exposure. In: Curr. Probl. Derm., S. Karger press, Vol. 15, p. 176-194.

16. Daynes, R.A., H-T. Chung, B. Robertson, L.K. Roberts and W.E. Samlowski. (1986) Immunomodulation by ultraviolet radiation: Prostaglandins appear to be involved in the molecular mechanisms responsible for UVR-induced changes in immune function. In: Effects of Changes in Stratospheric Ozone and Global Climate. Proc. of the UNEP/EPA International Conf. on Health and Environmental Effects of Ozone Modification and Climate Change. vol. 2: Stratospheric Ozone, p. 63-86.

17. Roberts, L.K., D.H. Lynch, W.E. Samlowski and R.A. Daynes. (1989) Ultraviolet light and modulation of the immune response. (Norris, D.A., ed.) In: Immune Mechanisms in Cutaneous Disease, Marcel Dekker, Inc., New York, pp. 167-216.

18. Araneo, B.A. and R.A. Daynes. (1990) Regulation of lymphokine production by the endogenous steroids: DHEA and vitamin D3. In: Advances in Gene Technology: The Molecular Biology of Immune Diseases and the Immune Response. ICSU Short Reports, Vol. 10. J.W. Streilein, et al., eds. IRL Press, Oxford, pp. 236.

19. Daynes, R.A. and B.A. Araneo. (1990) Regulation of Murine lymphokine Production in vivo: The lymphoid tissue microenvironment exerts regulatory influences over T-helper cell function. In: Advances in Gene Technology: The Molecular Biology of Immune Diseases and the Immune Response. ICSU Short Reports, Vol. 10. J.W. Streilein, et al., eds. IRL Press, Oxford, pp. 239.

20. Daynes, R.A. (1990) Immune system and ultraviolet light. In: Global Atmospheric Change and Public Health. White, J.C., ed. Elsevier Sci. Pub. Co., New York, NY, pp. 23-31.

21. Daynes, R.A. and B.A. Araneo. (1991) Regulation of T-cell function by steroid hormones. In: Cellular and Cytokine Networks in Tissue Immunity Meltzer, M.S., and A. Mantovani, eds. Wiley-Liss, New York, NY. Progress in Leukocyte Biology, Vol. II, pp. 77-82.

22. Meikle, A.W., R.A. Daynes and B.A. Araneo. (1991) Adrenal androgen secretion and biologic effects. In: Nelson, D.H. (ed.), New Aspects of Adrenal Cortical Disease (Endocrinology and Metabolism Clinics of North America). W.B. Saunders, Co., Philadelphia, PA, Vol. 20 (2), pp. 381-400.

23. Daynes, R.A. (1995) 1,25-dihydroxyvitamin D3. DHEA. In: Chapter 7: A Compendium of Vaccine Adjuvants and Excipients. Eds: F.R. Vogel and M.F. Powell. pp 141-228. In: Vaccine Design - The Subunit and Adjuvant Approach. Eds: M.F. Powell and M.J. Newman. Plenum Press, NY, NY. pp. 150 & 158 ISBN 0-306-44867-X

24. Hennebold, J.D., and R.A. Daynes. (1997) Microenvironmental Control of Glucocorticoid Functions in Immune Regulation. In: Steroid Hormones and the T-cell Cytokine Profile. G.A.W. Rook and S. Lightman (eds.) Springer-Verlag, London. pp 101-133.

25. Poynter, M.E., and R.A. Daynes. (1999) Restoration of Immunocompetence in Aging and Other Inflammatory Disease States by Dehydroepiandrosterone-3-Sulfate, an Activator of the Peroxisome Proliferator-Activated Receptor Alpha (PPAR). In: Dehydroepiandrosterone (DHEA) – Biochemical, Physiological and Clinical Aspects. M. Kalimi and W. Regelson (eds.) Walter de Gruyter & Co., Berlin. pp. 65-118.

Oral Presentations 1999-present:• January 1999, “Dysregulations in Essential Cell-signaling Systems with Aging: Causes and

Possible Corrective Interventions” Medical Affairs Seminar, Women’s Health Research Institute, Wyeth-Ayerst Pharmaceuticals, St. Davids, PA.


• May 1999, “Novel Vaccination Strategies for Inducing Mucosal Immunity” University of Rochester Medical Center, Rochester, NY.

• September 1999, “Aging Issues”, Satellite Symposia entitled “Confronting Aging and Disease: The Role of ERT/HRT”, The North American Menopause Society 10th Annual Meeting, New York, NY.

• October 1999, “Novel Vaccination Strategies for Inducing Mucosal Immunity”, University of California at Santa Barbara.

• January 2000, “Immunosenescence Beyond T Cells: Molecular Mechanisms, Therapeutic Interventions, and Primary Cellular Targets” Department of Cellular and Structural Biology Weekly Seminar Series, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.

• February 2000, “Immunosenescence Beyond T Cells: Molecular Mechanisms, Therapeutic Interventions, and Primary Cellular Targets” Molecular Biology Seminar Series, Department of Microbiology, Brigham Young University, Provo, Utah.

• July 2000, “The Immunobiology of Aging Beyond T Cells: Mechanisms, Cellular Targets, and Useful Interventions” Department of Microbiology and Immunology, University of California at Davis.

• March 2001, “Dysregulations in Essential Cell-signaling Systems with Aging: Causes, Consequences, and Potential Corrective Interventions” Pacific Northwest National Laboratory, Richland, Washington.

• March 2001, “New Insights into Enhancing the Efficiency of Vaccination in the Aged” ImAginE (Immunology and Aging in Europe) Meeting: Second International Conference on Basic Biology and Clinical Impact of Immunosenescence. Cordoba, Spain.

• December 2001, “Aging Immunobiology: Evaluation of a new PPAR digm” Mechanisms in Nutrient Regulation of Inflammation Session at the Joint Meeting of the British Society for Immunology’s Nutritional Immunology Group and British Inflammation Research Association BSI Annual Congress 2001, Harrogate, U.K.

• May 2002, “Discovery of an Immunobiologic Role for the Transcription Factor PPAR ” University of California at San Francisco.

• May 2002, “The Biology/Immunobiology of Aging: Can the Pathophysiology be Altered?” University of California at Merced.

• November 2002, “Immunity, Aging and the Transcription Factor PPAR ” Linus Pauling Institute, Corvallis, Oregon.

• February 2003, “Biology of the Aged Immune System: Causes, Consequences, and Corrective Interventions” Department of Microbiology, Immunology, and Pathology, Colorado State University, Ft. Collins, CO

• February 2003, “The Roles of PPARs in Lipid Metabolism, Inflammation, and Immune Cell Function” Gordon Conference on Periodontal Diseases, Session on The Role of Lipids as Transcriptional Regulators of Inflammation, Ventura, CA

• March 2004, “The Double-edged Sword of Life: The Aged Immune System” Rocky Mountain Genetics Conference, Park City, UT

• March 2005, “Vaccine adjuvants that promote the migration of antigen presenting cells from the skin to Peyers Patches are capable of inducing both systemic and common mucosal immunity” Keystone Meeting, Taos, NM

• September, 2005, “Designer vaccines for the 21 st Century: manipulation of dendritic cell migration in vivo to achieve optimal immune responses” Department of Biological Sciences, Purdue University, W. Lafayette, IN

PATENTS

Methods for Augmenting Immunological Responses Through the Administration of Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEA-S).

US Patent # 5,753,237US Patent # 5,919,465

Method for Enhancement of Production of Lymphokines and Applications Thereof.



Methods for Preventing Progressive Tissue Necrosis, Reperfusion Injury, Bacterial Translocation and Adult Respiratory Distress Syndrome.

US Patent # 5,489,581US Patent # 5,532,230US Patent # 5,583,126US Patent # 5,587,369US Patent # 5,635,496US Patent # 5,686,438US Patent # 5,811,418US Patent # 5,977,095 US Patent # 6,150,348US Patent # 6,187,767 B1Australian Patent # 747137

Vaccine Compositions and Method for Enhancing an Immune Response. US Patent # 5,562,910US Patent # 5,837,269

Vaccine Compositions and Method for Induction of Mucosal Immune Response via Systemic Vaccination.



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