lipid metabolism-2 synthesis of fatty acids

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  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    ]{cvh`}k} jo Obvv{ Bmkf}bcf Vtkbm{ili{m`tji

    Obk}bi Ehbvkd NF5 WhF

    Obmpiv{ jo N`fkmkc`) Pck`t}kv{ joAjtfbc

    Obvv{ Bmkf ]{cvh`}k} T`rpkt`}

    Mbtdjc ]jptm`1 Bm`v{i MjBT`fpmkcl Wj|`t1 CBFWH@c`tl{ Kcwpv1 BVW

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    \h{ @c`tl{ :

    Obvv{ Bmkf

    Bm`v{i MjBL

    j1 .`

    Bm`v{i MjB

    Obvv{ BmkfL

    j1 %`

    \h{ @c`tl{ :Obvv{ Bmkf

    Bm`v{i MjBLj 1 .`

    Bm v{i MjB % c(BVW+

    Obvv{ Bmkf % c(BFW+Lj 1 .`

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    OB F`ltbfbvkjc bcf ]{cvh`}k}Bm{i MjB (c+

    Jxkfbvkjc

    H{ftbvkjc

    Jxkfbvkjc

    Vh{ji{}k}

    Bm{i MjB (c.4+ % Bm`v{i MjB

    Bm{i MjB (c%4+

    t`fpmvkjc

    f`h{ftbvkjc

    t`fpmvkjc

    mjcf`c}bvkjc

    Bm{i MjB(c+ % Nbijc{i MjB

    Bm`v{i MjB

    Mbtdjx{ibvkjc jo Bm`v{i MjB

    Wtjfpm`} Nbijc{i MjBJ J J

    MH=.M.MjB.JM.MH4.M.MjB

    Bm`v{i MjB Mbtdjx{ib}`

    Dkjvkc.Mjcvbkckcl @cq{n`

    MJ4BVW BFW % Wk

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    Obvv{ Bmkf ]{cvhb}` Mbvbi{q`} vh`

    t`nbkckcl }v`w}

    Npivkopcmvkjcbi @cq{n` Mjnwi`x

    Fkn`t jo v|j Kf`cvkmbi Mhbkc}

    @bmh hb} ]``c Mbvbi{vkm Bmvkkvk`}

    Jc` bmvkkv{ k} Mjcf`c}kcl @cq{n` |kvh]H

    Jc` Fjnbkc k} Ikce`f vj Whj}whjwbcv`vh`kc`

    \kvh T`bmvk` .]H

    Bf`ckc`

    Tkdj}`

    4whj}whbv`}

    Wbcvjvh`ckm bmkf

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    Obvv{ Bmkf ]{cvhb}` Mbvbi{q`} vh`

    t`nbkckcl }v`w}

    Npivkopcmvkjcbi @cq{n` Mjnwi`x

    Fkn`t jo v|j Kf`cvkmbi Mhbkc}

    @bmh hb} ]``c Mbvbi{vkm Bmvkkvk`}

    Jc` bmvkkv{ k} Mjcf`c}kcl @cq{n` |kvh ]H

    Jc` Fjnbkc k} Ikce`f vj Whj}whjwbcv`vh`kc`

    \kvh T`bmvk` .]H

    Mbttk`} Kcv`tn`fkbv`} fptkcl Mbvbi{}k} (Bm{i) Bm`v{i bcf Nbijc{i Ltjpw}+ Ecj|c b} Bm{i Mbttk`tWtjv`kc (BMW+

    Obvv{ Bmkf ]{cvh`}k} (J`tk`|+

    Bm v{i.M@ (Bm{i.M@+ % Nbijc{i BMW(c+ (=+

    MJ4

    E`vjbm{i BMW(c%4+

    Bm{i BMW

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    MH=MJs].M@ % JJM.MH4.MJsBMWBm`v{i Nbijc{i.BMW

    (Bm{i+

    MJ4H].M@

    J

    MH=M.MH4.MJsBMW

    E`vjbm{i. BMW

    T`fpmvkjc jo vh` E`vjbm{i LtjpwJ

    MH=M.MH4.MJsBMW E`vjbm{i. BMW

    JHi

    MH=MH.MH4.

    H4J

    MH=MH>MH.

    MH=MH4.MH4.MJsBMW

    CBFWH

    CBFWH

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

    7/19

    ]{cvh`}k} jo Wbinkvbv` d{ Obvv{ Bmkf ]{cvhb}`

    ]{cvh`}k} jo Wbinkvbv` d{ Obvv{ Bmkf ]{cvhb}` (Mjcv#+

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

    8/19

    ]{cvh`}k} jo Wbinkvbv` (c`v t`bmvkjc+

    Hj| nbc{ m{mi`} jo }{cvh`}k} (Mjcf`c}bvkjc+:! i`}} vhbc2? mbtdjc}

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    Kcvtjfpmvkjc jo Fjpdi` Djcf}

    ]{cvh`}k} jo Njcjpc}bvptbv`f OB

    . Ji km Bmkf 281;

    . Wbinkvji km 2?1;

    Kc `cfjwib}nkm t`vkmpipn Cj fjpdi djcf mbc d` kcvtjfpm`f d`{jcf

    mbtdjc ; kc hpnbc

    Kcvtjfpmvkjc jo Fjpdi` Djcf} (Mjcv#+]v`btj{i MjB Wbinkvj{i MjB

    CBFWH % J4

    CBFW% % 4H4J

    Ji`j{i MjB Wbinkvji`j{i MjB

    ; F`}bvptb}`5 M{vjmhtjn` d0

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

    15/19

    Kcvtjfpmvkjc jo Fjpdi` Djcf} (Mjcv#+

    Ojtnbvkjc bcf Njfkokmbvkjc joWji{pc}bvptbv`f OB

    .@ijclbvkjc

    . F`}bvptbvkjcBffkvkjcbi fjpdi` djcf} mbc d` kcvtjfpm`f d{1

    6 F`}bvptb}`

    0 F`}bvptb}`? F`}bvptb}`

    Njfkokmbvkjc joWji{pc}bvptbv`f OBIkcji`km 2814;)24F`}bvptbvkjc

    281=?);)24 :

    @ijclbvkjc471=8)22)26 :

    F`}bvptbvkjc

    47160)8)22)26 : Btbmhkfjckm

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    Dkj}{cvh`}k} jo Vtkbm{ili{m`tji /

    Whj}whjbm{ili{m`tji

    L

    I

    [

    M

    @

    T

    J

    I

    OBVV[BMKF

    OBVV[BMKF

    OBVV[BMKF

    VTKBM[ILI[M@TJI

    L

    I

    [

    M

    @

    T

    J

    I

    OBVV[BMKF

    OBVV[BMKF

    WHJ]WHJBM[ILI[M@TJI

    WHJ]WHBV@

    BIMJHJI

    Whj}whjvbfkm Bmkf k} Mjnnjc Kcv`tn`fkbv`

    L

    I

    [

    M

    @

    T

    JI

    OBVV[ BMKF

    OBVV[ BMKF

    W H J] W H JB M [ ILI[ M @ T JI

    WHJ ]WHBV @

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    Dkj}{cvh`}k} jo Vtkbm{ili{m`tjiT`rpkt`}

    Bm{isMjB (Bmvk` ojtn jo OB+ Li{m`tji Whj}whbv`

    \h{ Bmvk` ojtn:

    VBL % H4J FBL % OB L `FBL % OB VBL % H

    4J L %`

    FBL % Bm{isMjB VBL L `

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    Wtjfpmvkjc jo Li{m`tji Whj}whbv`. Li{m`tji % BVW ... Li{m`tji = Whj}whbv`

    @cq1 Li{m`tji Ekcb}`Cjv kc Bfkwj}` vk}}p`

    MH4JH MH4JHK K

    M > J M HJHK K

    MH4JWJ= MH4JWJ=CBFH CBF%

  • 8/3/2019 Lipid Metabolism-2 Synthesis of Fatty Acids

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    Wtjfpmvkjc jo Li{m`tji Whj}whbv`

    FHBW

    Li{m`tji. OBsMjB

    VBL

    Li{m`tji % Obvv{ Bmkf}

    W

    Lipmj}`