Alterations in skin blood flow at the fingertip of patients with circulatory shock are related to disease severity and mortality

Mongkolpun et al.

Digital Supplementary Content

Figure S1. Thermostatic skin laser Doppler (SLD) probe (Reference number 457, Perimed, Jarfalla, Sweden)

Figure S2. Lactate concentration (medians with 25th and 75th percentiles) during the study period in survivors and non-survivors (numbers of patients at each time point shown in brackets). *p<0.05 vs survivors; ap<0.05 vs baseline in the same group

Figure S3. Skin blood flow (medians with 25th and 75th percentiles) at 37°C (SBF37) during the study period in survivors and non-survivors. *p<0.05 vs survivors; ap<0.05 (vs 0 h in the same group); bp<0.05 between the indicated times in the same group; #p<0.05 vs healthy volunteers. APU: arbitrary perfusion units

Figure S4. Finger temperature (medians with 25th and 75th percentiles) during the study period in survivors and non-survivors (numbers of patients at each time point shown in brackets). *p<0.05 vs survivors

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Figure S5A, S5B. Skin blood flow (SBF) and ∆SBF/∆T (medians with 25th and 75th percentiles) in patients with septic and with non septic shock, ap<0.05 vs baseline in the same group; bp<0.05 between the indicated times in the same group

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Figure S6A, S6B. Skin blood flow (SBF) and ∆SBF/∆T (medians with 25th and 75th percentiles) in septic shock survivors and non-survivors; Figure S6C, S6D: SBF and ∆SBF/∆T in survivors and non-survivors in non-septic shock, *p<0.05 vs survivors, ap<0.05 vs baseline in the same group; bp<0.05 between the indicated times in the same group

Figure S7. Peripheral perfusion index (PPI) (medians with 25th and 75th percentiles) in survivors and non-survivors during the study period. *p<0.05 vs survivors

Figure S8. Correlation between baseline cardiac index and skin blood flow (SBF) in the 55 patients who had cardiac output monitoring. APU: arbitrary perfusion units

Figure S9. The correlation between baseline norepinephrine dose and SBF. APU: arbitrary perfusion units

Figure S10. Receiver operating characteristic (ROC) curves of baseline parameters for prediction of mortality in patients with septic shock. ScvO2: central venous oxygen saturation; CRT: capillary refill time; SBF: skin blood flow; AUC: area under the curve

Figure S11. Receiver operating characteristic (ROC) curves of baseline parameters for prediction of mortality in patients with non-septic shock. ScvO2: central venous oxygen saturation; CRT: capillary refill time; SBF: skin blood flow; AUC: area under the curve