list of annexures sr. no. name of annexure of annexures sr. no. name of annexure i list of products...

LIST OF ANNEXURES

SR. NO. NAME OF ANNEXURE

I List of products with their production capacity

II Layout Map of the Plant

III Brief Manufacturing Process Description with Chemical and Mass Balance

IV Details of Water Consumption Wastewater Generation

V Effluent Treatment Scheme

VI Details of Hazardous /Solid Waste Generation, Handling and Disposal

VII Details of Air pollution Control System (Stack & Vent)

VIII Details of Hazardous Chemicals Storage & Handling

IX Socio-economic Impacts

X Proposed Terms of Reference for EIA studies

ANNEXURE – I

A- LIST OF PRODUCTS WITH THEIR PRODUCTION CAPACITY

No. Product Product Capacity

1 N-BOC-3-Piperidone

25 MT/Month

2 1,2-Dibromotetrachloroethane

3 1,4-BENZODIOXANE METHANOL

4 1,4-Dioxaspiro(4,5)Decan-8-One

5 1,5-Diphenyl-1,4-pentadien-3-one

6 1,2,5,6-Di-O-Isopropylidene-D-Mannitol

7 1-benzyl-3-piperidone

8 1-Pyrrolidinecarbodithioic acid, ammonium salt

9 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane

10 2,2,6,6-Tetramethyl-3,5-heptanedione

11 2,2-Bithiophene

12 2,3-benzofurane

13 2,5-Bis(chloromethyl)-p-xylene

14 2-Acetylcyclohexanone

15 2-aminopyrazine

16 2-bromo-p-xylene

17 2-Iodoethanol, stabilized with copper

18 2-Methoxyhydroquinone

19 2-Quinolinecarboxaldehyde

20 3,3,5,5-Tetramethylcyclohexanone

21 3,5-Pyrazoledicarboxylic acid monohydrate,

22 3-hydroxy-1,2,3,4-tetrahydrofuran

23 4,4'-Di-tert.-butylbiphenyl

24 4,6-Diamino-2-mercaptopyrimidine, hydrate

25 4-Biphenylcarbonyl chloride

26 4-Cyano-4-phenylpiperidine hydrochloride

27 4-quinoline carboxaldehyde

28 4-tert.-Butylcalix(4)arene-tetraacetic acid tetraethyl ester

29 5,6-dimethoxy indanone

30 burgess regent

31 alpha methylglutaric acid

32 Methylthiazolyldiphenyl-tetrazolium bromide

33 dipropyl pthalate

34 copolymer methylstyrene-chloroacrylate

35 bENZETHONIUM CHLORIDE

36 DIPHENYL IODONIUM NITARTE

37 a-Bromo-g-butyrolactone,

38 Benzeneseleninic anhydride

39 Bis(2-hydroxyethyl)dimethylammonium chloride

40 Bis(phenylsulfonyl)Methane

41 Bis(Phenylthio)methane

42 Calix-4-Arene

43 Cinnamyl chloride

44 Cyano-4,6-dimethyl-2-hydroxypyridine

45 cyclopropylphenylsulphide

46 DibenzothiophenE

47 Diglycolic anhydride

48 Diphenyl ditelluride

49 Diphosphorus tetraiodide

50 1,1-dimethoxy cyclohexanone

51 L-(-)-a-Amino-g-butyrolactone hydrobromide

52 l-methionine sulphone methyl ester

53 Methyl Glycolate

54 methyl-3-hydroxybutanoate

55 Methysulfuric acid sodium salt

56 N,N-Dimethylphenylenediamine dihydrochloride

57 N-Aminorhodanine

58 N-boc-3-pyrrolidinone

59 N-BOC-trans-4-hydroxy-L-proline methyl ester

60 nitro phenylselenocyanate

61 Nonyl amine

62 N-tertbutoxy carbonylethylenediamine

63 Phenyl Selenyl Bromide

64 Phenyltrimethylammonium tribromide

65 Phthalan 496-14-0

66 Potassium selenocyanate

67 S(+) -2-OCTANOL

68 S,S -2,5-HEXANEDIOL

69 Tetrahydrothiopyran-4-one

70 Trans-2-Phenylcyclopropane-1-carboxylic acid

71 Triisopropanolamine cyclic borate 101-00-8

72 Tropinone

73 2-amino-5-chlorobenzenesulphonic acid

74 4-Methyl-2-pipecolic acid acid HCL

75 N-Methylhydrazinecarboximidamide hydroiodide

76 Tetraphenylcyclopentadienone

77 4,6-dimethylpyrimidine

78 2-chlro-3,4-dimethoxy benzaldehyde

79 N,N-dimethyl Sulfomoyl chloride

80 3-acetamido-6-methoxybenzene sulfonyl chloride

B- LIST OF BY- PRODUCT

No. By-Product Capacity (MT/Month)

1 Aluminium Chloride 83

2 Hydrogen Bromide 15

3 Dilute Hydrochloric Acid 13

4 Sodium Acetate 16

5 Sodium Bromide 17

6 Potasium Chloride 21

7 Sodium Iodide 36

8 Sodium Sulphite 25

C- LIST OF RAW MATERIALS

Sr.

No. Product Raw Material

Quantity Per MT

1. N-BOC -3-pieridone 1-bnenzyl-3-piperidone 0.94

Methanol 9.49

Pd/C 0.04

DiBOC 1.09

THF 4.02

Sodium bicarbonate 0.42

HCl 0.62

Charcoal 0.05

Hyflow 0.05

2. 1,2-Dibromotetrachloroethane

Tetrachloroethane 0.53

Bromine 1.01

Ethyl alcohol 1.58

Sodium hydroxide 0.25

3. 1,4-benzodioxane methanol

Catachol 0.67

Epichlorohydrine 0.45

Sodium Hydroxide 0.27

Dichloromethane 2.67

Toluene 1.33

4. 1,4-dioxaspiro[4.5]decane

1,4-cyclohexane dione 0.65

Ethylene glycol 0.36

Toluene 4.53

Isopropyl alcohol 2.03

Resin 0.05

5. 1,5-Diphenyl-1,4-pentadien-3-

one

Benzaldehyde 0.98

Acetone 0.27

Methanol 5.56


Ethyl acetate 2.31

Charcoal 0.09

Hyflow 0.09

6.

Di-O-Isopropylidene-1,2;5,6-D-

mannitol (Diacetone-D-

mannitol).-

D-Mannitol 0.73

Acetone 1.08

Zinc chloride 0.79

Ether 1.05

charcoal 0.44

Hyflow 0.43

D-Mannitol 0.73

7. 1-Benzyl -3-Piperidone

N-Benzylglycine ethyl ester 2.36

Ethyl 4-chlorobutyrate 1.97

Sodium carbonate 1.56

Toluene 23.06

Potassium iodide 4.34

Sodium ethoxide, powder 0.81

Hydrochloric acid, c.p. 3.78

Ammoniumhydroxide, c.p. 3.72

Acetone 0.88

Hydrochloric acid in IPA 5.9N 1.70

Carbon 0.1

hyflow 0.1

8. 1-Pyrrolidinecarbothioic acid,

ammonium salt

Carbon disulfide 0.47

Pyrrolidine 0.44

Methanol 4.63

Ammonia-25 % 0.79

Petroleum ether 1.23

carbon 0.03

Hyflow 0.03

9.

2-(3-Chloropropyl)-2-(4-

fluorophenyl)-1,3-dioxolane

Fluorobenzene 0.43

4-chlorobutonyl chloride 0.54

Aluminium chloride 0.59


Ethylene glycol 0.28

Trimethyl orthoformate 0.47

Toluene 3.56

p-toluenesulphonic acid 0.06

Carbon + hyflow 0.09

10. 2,2,6,6-Tetramethyl-3,5-

heptanedione

sodium hydride 0.16

1,2-dimethoxy ethane 4.36

ethyl pivalate 0.87

3,3-dimethyl butanone 0.67

sulfuric acid 0.66

sodium hydroxide 0.27

Hexane 6.71

Charcoal 0.07

Hyflow 0.07

11 2,2-bithiophene

2-bromothiophene 1.05

Magnesium 0.15

Tetrahydrofurane 15.48

Ni catalyst 0.01

Diethyl ether 3.23

Ethanol 2.58

12 2,3-Benzofuran

2-hydroxy benzaldehyde 1.03 Chloroacetic acid 0.80 Sodium hydroxide 0.34 Acetic acid 3.39 Acetic anhydride 3.39 Carbon 0.08 hyflow 0.08

13 2,5-Bis(chloromethyl)-p-xylene

p-Xylene 0.57 Toluene 3.01 HCl Gas 0.38 paraformaldehyde 0.32

14 2-Acetyl Cyclohexanone

cyclohexanone 0.70 Pyrrolidine 0.51 Toluene 3.57 Acetic anhydride 0.73

15 2-Aminopyrazine

2-chloropyrazine 1.39 Ammonia gas 0.45 Methanol 10.67 Ethylacetate 6.67 carbon 0.13 Hyflow 0.13

16 2-Bromo-p-xylene

p-Xylene 1.86 Bromine 0.94 Ferric chloride 0.01

17 2-Iodoethanol

Sodium iodide 0.97 2-chloroethanol 0.52 Acetone 5.22

18 2-Methoxy hydroquinone

Vaniline 1.19 Hydrogen peroxide 0.27 Sodium hydroxide 0.31 Hydrochloric acid 0.94 Ethyl acetate 10.94 Toluene 5.47 Carbon 0.08 Hyflow 0.08

19 2-Quinoline carboxaldehyde

Quinaldine 0.91

1,4-dioxane 4

Selenious acid 1.414

Carbon 0.04

hyflow 0.04

20

3,3,5,5 tetramethylcyclohexanone Methyl Mganesium bromide 0.85

Ether 8.5

Isophorone 0.9858

Hydrochloric Acid 0.3928

Cuprous Acetate 0.0108

21 3,5-Pyrazoledicarboxylic acid

Acetyl acetone 0.7246


Hydrazine sulphate 0.942

Hydrogen peroxide 0.3261

acetone 2.1739

Carbon+hyflow 0.1449

22 3-hydroxy-1,2,3,4-tetrahydro

Furan

1,2,4-trihydroxybutane 1.3086

p-tolune sulphonic acid 0.0124

23 4,4′-Di-tert-butylbiphenyl

Biphenyl 0.77

Nitromethane 7.69


Hexane 5

Tert-butyl chloride 0.47

24 4,6-Diamino-2-

mercaptopyrimidine,hemihydrate

Thiourea 0.5352

Malanonitrile 0.4648

Sodium methoxide 0.38032

Methanol 5.35212

Acetone 3.52112

Hydrochloric acid 0.85212

Carbon+Hyflow 0.0704

25 Biphenyl-4-carbonyl chloride Thionyl chloride 1.194

N.N-Dimethyl formamide 0.0074

26 4-Cyano-4-phenylpiperidine HCl

N-(2-hydroxyethyl)-N-

benzylmethylamine 0.8784

chloroform 9.45952

Thionyl chloride 1.08112

Sodium sulphate 0.045

Benzyl cyanide 0.527


Toluene 4.955

Acetone 3.1532

Isopropanol 9.009

Pd/C 0.045


Hydrogen 0.1802


Carbon 0.045

Hyflow 0.045

27 4-Quinoline carboxaldehyde

lepidine 0.91

1,4-dioxane 4

Selenious acid 1.414

Carbon 0.04

hyflow 0.04

28 4-tert-Butylcalix[4]arene-

tetraacetic acid tetraethyl ester

p-tert butyl phenol 0.715

Formaldehyde 0.129

Bromo ethyl acetate 0.719

Potassium carbonate 0.594

Toluene 6.4

Acetone 8

Ethanol 7.5

Diphenyl ether 6.4

carbon 0.1

hyflow 0.1

29 5,6-dimethoxy-1-indanone

5,6-dimethoxy benzaldehyde 0.96

Malonic acid 0.60

Pyridine 3.22

Methanol 11.62

Pd/C 0.058



Ethylacetate 6.98

Carbon 0.058

Hyflow 0.12

30 Burgess reagent

Chlorosulfonylisocyanate 0.63

Methanol 0.14

Toluene 2.22

Triethylamine 0.45

31 2-Methylglutaric acid

Dimethylmalonate 0.98

Methylmethacrylate 0.74



Methanol 8.89

Charcoal/Hyflow 0.07

32 Methylthiazolyldiphenyl-

tetrazolium bromide

Methylethylketone 0.18

Bromine 0.40

Thiourea 0.19

Ethylene dichloride 1.83

Benzaldehydephenyl hydrazine 0.50

Methanol 1.91

33 Dipropyl phthalate

Phthalic anhydride 0.62

2-propanol 0.50

Toluene 3.57

p-Toluenesulphonic acid 0.01

34 CopolymerMethyl

styreneChloroacrylate

Alphamethyl chloroacrylate 0.50

Alphamethyl styrene 0.50

Methanol 5.04

AIBN 0.01

Water (for Washing) 4.10

35 Benzethonium chloride

Digol 0.25

Thionyl Chloride 0.56

P-tert octyl phenol 0.48

Hexane 1.76

Dimethylamine 0.11

Methanol 2.35

Benzyl chloride 0.30

Methylethylketone 1.88

Charcoal+hyflow 0.06

36 Diphenyl iododonim nitrate

Benzene 0.23

Sodium iodate 0.58

Sodium nitrite 0.25

Acetic acid 1.31

Acetic anhydride 0.35

Methanol 1.46

37 Alpha bromo gamma

butyrolactone

Gamma Butyrolactone 0.55

Bromine 1.01

Acetic acid 5.45


38 Benzene seleninic anhydride

Diphenyldiselenide 0.95

1,4-dioxane 9.40

Toluene 10.00


39 Bis(2-hydroxy ethyl) dimethyl

ammonium chloride

Dimethylaminoethanol 0.53

2-chloroethanol 0.47

Acetonitirile 5.62

Ether 0.59

40 Bis(phenylsulfonyl)methane

Bisphenylthiomethane 0.97

Acetic acid 3.33

Acetic anhydride 0.83

Hydrogen Peroxide (30 %) 0.48

Ethanol 5.00

Charcoal + hyfllow 0.08

41 Bisphenylthiometahne

Thiophenol 1.03

Triethyl amine 0.18


NaOH 0.07

42 Calix[4]arene

t-butylcalix[4]arene 1.45

Toluene 15.2

Phenol 0.22


Chloroform 8.00

Methanol 8.00

Carbon 0.10

hyflow 0.10

43 Cinnamyl chloride

Cinnamyl alcohol 0.94

Thionyl Chloride 0.83

Toluene 4.54

N N –dimethylformamide 0.01

44 2-Hydroxy-4,6-dimethylpyridine-3-

carbonitrile

Cyanoacetamide 0.57

Acetylacetone 0.68

Methanol 5.07

Piperdine 0.01

45 Cyclopropyl phenyl sulphide

Thiophenol 0.73

Cyclopropyl bromide 0.80


Toluene 7.33

46 Dibenzothiophene

Biphenyl 0.35


Sulphur 7.5

Toluene 5.00

methanol 0.10

carbon 0.10

hyflow 6.00

Digol 0.97

60% Nitric Acid 4.59

Acetic Anhydride 6.65

Diisopropyl ether 2.29

Carbon +Hyflow 0.18

48 Diphenylditelluride

Magnesium 0.06

Tetrahydrofurane 4.4

Chlorobenzene 0.27

Diethylether 5.00

Hexane 6.00

Tellurium 0.62

49 Diphosphorus tetraiodide

Iodine 0.94

Phosphorus 0.12

Carbon disulphide 2.70

hexane 0.23

50 1,1-dimethoxy cyclohexan

Cyclohexanone 0.73

P-toluene sulphonic acid 0.01

Trimethyl orthoformate 0.77

51 alpha-amino-gamma-

butyrolactone.HBr

l-methionine 0.90

HBr Gas 0.48

Formic acid 9.03

n-Butanol 3.63

52 l-methionine sulphone methyl

ester

l-methionine 0.85


Methanol 8.24


Acetic acid 3.41

Ethyl acetate 4.54

Charcoal/hyflow 0.11

53 Methyl glycoltae

Glycolic acid 1.00

Methanol 10.00

2,2-dimethoxy propane 0.68

p-toluenesulphonic acid 0.02

54 Methyl (R)-3-hydroxybutyrate

Methyl acetoacetate 1.07


Enzyme 0.01

Metyl tert butyl ether 5.37

55 Sodium methyl sulfate

Dimethyl suplphate 0.99

Methanol 6.69

Soduym carbonate 0.66

56 N,N-dimethylamine-p-

phenylenedimaine. HCl

p-Nitro Chlorobenzene 0.83

N,N-dimethyl amine 0.24

Dimethyl formamide 8.26

Hydrogen 0.03

Raney Nickel 0.15

Methanol 7.89

Hydrogen chloride gas 0.39

Charcoal+Hyflow 0.05

57 N-Aminorhodanine

Hydrazine hydrate 0.34

Carbon disulphide 0.51

Methanol 3.38

Chloroethyl acetate 0.82

Carbon 0.07

Hyflow 0.07

NaOH 0.27

58 N-BOC-3-pyrrolidinone

Benzyl Amine 0.58

Ethyl acrylate 0.54


Ethylchloroacetate 0.66



Toluene 4.32


Pd/C 0.05

Hydrogen gas 0.01

Methanol 4.32

DiBOC 1.18

1,4-Dioxane 4.05


59 N-BOC trans-4-hydroxy proline

methyl ester

Trans-4-hydroxy proline 0.58


Methanol 5.82

DiBOC 0.37

MDC 5.33

Potassium Carbonate 0.61

Carbon +hyflow 0.09

60 2-nitrophenylselenocyanate

2-Nitroaniline 0.61


Sodium nitirite 0.30

Potassium selenocyanate 0.63

Carbon 0.05

Hyflow 0.07

61 Nonyl amine

Decanoyl chloride 1.41

Ammonium hydroxide 0.24

Bromine 1.18

Sodiummethoxide 1.50

Ethanol 5.56

62 N-BOC ethylene diamine

Ethylene diamine 0.42

Di Boc 1.51

Pottasium carbonate 0.96

Tetrahydrofuran 4.17

63 Phenylselenyl bromide

Diphenyldiselenide 0.66


Bromine 0.34

Pentane 4.00

64 Trimethylphenylammonium

tribromide

N,N-dimethylaniline 0.32

Toluene 3.2

dimethyl sulfate 0.34

hydrobromic acid 0.67

Bromine 0.42

Carbon 0.01

hyflow 0.01

Acetic acid (R/C) 2.5

65 Phthalan

o-Dichlorobenzene 1.41


Benzyltriethylammonium chloride 0.01

66 Pottasium selenocyanate

Methanol 4.4

Selenium 0.45

Potassium cyanide 0.55

Carbon 0.05

hyflow 0.05

Methanol 4.4

67 (+)-S-2-Octanol

2- Octanol 1.076


Enzyme 0.01

68 S,S-2,5-Hexanediol

2,5-hexanedione 1.088


Enzyme 0.024

Glucose 0.32

Buffer solution (pH-6.5) 3

N-methylpiperidone 1.0762

Methyl iodide 1.3428

Ether 4.762

Sodium sulphide 0.7428

Hexane 5.7142

Carbon 0.0952

hyflow 0.0952

70 trans-2-cyclopropanecarboxylic

Acid

Cinnmic acid 1.13


Tert butyl alcohol 0.56

N,N-dimethyl aniline 0.92

Sodium hydride 0.18

Trimethyl sulfoxonium iodide 1.68

Sulfuric acid 0.75


Ether 11.45

Toluene 11.45

Sodium sulphate 0.15

Sodium hydrooxide 0.30

Hyflow +carbon 0.19

71 Triisopropanolamine cyclic borate

Triisopropanolamine 1.01

Boric acid 0.32

Toluene 3.72

Pet ether 3.72

72 Tropinone

2,5-dimethoxy furane 1.02


Methyl amine HCl 0.52

Acetone dicarboxylic acid 1.13

Acetic acid 0.47

Sodium hydroxide, 0.31


73 2-amino-5-

chlorobenzenesulphonic acid

P-CHLOROANILINE 0.67

Sulfuric acid 0.96

Calcium hydroxide 0.42

Methanol 4.054

74 4-Methylpipecolic acid .HCl

2-methylpipecol 0.55

Methylformate 0.33

Methanol 5.02

Acetone 4.47

Charcoal +Hyflow 0.14

75 N-

Methylhydrazinecarboximidamide

hydroiodide

Thiosemicarbazide 0.42

Methyl Iodide 0.65

Methyl amine 0.14

Methanol 4.21


Hyflow+ Carbon 0.11

76 Tetraphenylcyclopentadienone

Benzyl 0.56

Dibenzyl Ketone 0.56

Toluene 3.73

Ethyl alcohol 2.13

77 4,6-Dimethylpyrimidine

Formamide 0.83

Acetylacetone 0.93

P-Toluenesulfonic acid 0.009

Ethyl Acetate 6.94

Carbon +Hyflow 0.23

78 2-chlro-3,4-dimethoxy

benzaldehyde

3-hydroxy-4-methoxybenzaldehyde 0.85

Dimethyl formamide 6.70

Dimethyl sulphate 0.70


Hexane 4.47

Charcoal +Hyflow 0.14

79 N,N-dimethyl Sulfomoyl chloride

Dimethylamine HCl 0.61

Sulfuryl chloride 1.01


80 3-Acetamido-6-methoxy benzene

sulfonyl chloride

4-methoxy acetanilide 0.78

Chlorosulphonic acid 0.55

Acetone 5.69

ANNEXURE – II

PLANT LAYOUT

Land Area Breakup

No Detail Area (m

2)

1 Plant Area 759

2 Open Area 173

3 Green Belt Area 1128 (54 %)

4 Total 2060

ANNEXURE – III

MANUFACTURING ACTIVITIES

1.0 N-BOC-3-Piperidone

Manufacturing Process:

The 1-benzyl-3-piperidone is dissolved in methanol and debenzylated with Pd/C to get 3-

piperidone which is dissolved In tetrhydrofurane and treated with Ditert butyl dicarbonate

in presence of sodium bicarbonate , neutralized with 1 N hydrochloric acid and the

Tetrhydrofurane is recovered the product is extracted Dichloromethane , the solvent is

recovered and the product is purified by vacuum Distillation.

Chemical Reaction:

N

O

1-Benzyl -3-Piperidone

Pd/C

Methanol NH

O

3-Piperidone

DiBOC THF NaHCO3

- CO2 -NaCl

HCl

N

O

BOC

N-BOC-3-Piperidone

-H2O

-tert Butyl alcohol( )

( )

Mass Balance:

Sr.

No

INPUT Qty. Output Qty. Remark

kgs kgs

1 1-bnenzyl-3-piperidone 237.45 N-BOC -3-pieridone 250.00 Product

2 Methanol 2374.35 Methanol (Recovered) 2361.80 Recycled

3 Pd/C 11.30 THF(Recovered) 992.45 Recycled

4 DiBOC 273.85 Carbondioxide gas 110.55

5 THF 1005.05 Pd/C (Recovered) 11.30 Recycled

6 Sodium bicarbonate 105.55 Sodium chloride 72.85 Dissolved salt to

ETP

7 HCl 157.05 Solid waste 25.15 To TSDF site

8 f 2005.05 Aqueous Effluent 2348.25 T o ETP

9 Charcoal 12.55 Process loss 22.40

10 Hyflow 12.55

6194.75 6194.75

2.0 1,2-Dibromotetrachloroethane


Tetrachlorethane is reacted with bromine in presence of UV light to get 1,2-

dibromotetrachloroethane , the product is recrystalised from ethyl alcohol.

Chemical Reaction:

Cl

Cl Cl

Cl

+ Br Br

Cl

Cl Cl

Cl

BrBr

Tetrachloroethane 1,2-dibromo tetrachloroethane

2 NaBr2 H2O+ +2

2 NaOH

Mass Balance:

Sr.

No


Kgs Kgs

1 Tetrachloroeth

ane

132.55 1,2-

Dibromotetrachloroet

hane

250.00 Product

2 Bromine 253.95 Ethyl acetate 380.95 Recovered and recycled

3 Ethyl alcohol 396.85 Sodium bromide 163.50 To be sold

4 Water(washing) 625.00 Aq Effluent (From

Washing)

672.65 To ETP

5 Sodium

hydroxide

63.50 Process loss 4.75

Total 1471.85 1471.85

3.0 1,4-Benzodioxane Methanol


The catachol, Epichloro hydrine, sodium hydroxide and water mixed together and refluxed

till completion of reaction, the product is extratcted with dichloromethamne, isolated and

crude product is recrystalised from Toluene to get pure product.

Chemical Reaction:

OH

OHO

OH

+

O

OOH

NaOH

+ OH2

CATACHOL EPICHLOROHYDRINE 1,4-BENZODIOXANE METHANOL

Mass Balance:

Sr.

No


Kgs Kgs

Catachol 166.68 1,4-benzodioxane methanol 250.00 Product

Epichlorohydrine 112.10 Dichloromethane(recovered) 633.33 Recycled

Sodium

Hydroxide

66.68 Toluene(recovered) 316.68 Recycled

Water 1208.33 distillation residue 8.78 To Incinaration

Dichloromethane 666.68 Aqueous effluent 1305.00 To ETP

Toluene 333.33 process loss 40.00

Total 2553.78 2553.78

4.0 1,4-Dioxaspiro[4.5]Decane


1,4-cyclohexanedione is reacted with ethylene glycol using resin as catalyst in refluxing

toluene , the water is continuously removed , toluene recovered and product is crystallized

from isopropyl alcohol.

Chemical Reaction:

O

O

+OH

OH

Resin

TolueneIsopropyl alcohol

O

O O

1,4-cyclohexanedione 1,4-dioxaspiro[4.5]decane

Mass Balance:

Sr.

No


Kgs Kgs

1 1,4-cyclohexane

dione

325.60

1,4-

dioxaspiro[4.5]decane 500.00

Product

2 Ethylene glycol 180.25 Toluene (Recovered) 2209.30 recycled

3 Toluene

2267.45

Isopropyl alcohol

(Recovered) 988.45

recycled

4 Isopropyl alcohol 1017.45 Aqueous Effluent 1607.55 To ETP

5 Water (washing ) 1581.40 Resin (regenerated) 25.00 Recycled

6 Resin 25.00 Process loss 66.85

Total 5397.15 5397.15

5.0 1,5-Diphenyl-1,4-pentadien-3-one


Sodium Hydroxide is mixed with water and methanol, To this mixture is added

Benzaldehyde and acetone. At room temp the precipitated product is filtered and mother

liquor is recycled for next batch after loss make up with Methanol , the crude product is

recrystalised from Ethyl acetate.

Chemical Reaction:

O

HCH3

CH3

O

+

NaOH

WaterMethanol

O

Benzaldehyde Acetone1,5-Diphenyl-1,4-pentadien-3-one

Mass Balance:

Sr.

No


Kgs Kgs

1 Benzaldehyde 490.75 1,5-Diphenyl-1,4-pentadien-3-

one 500 Product

2 Acetone 134.25 Aqueous Mother Liquor

(methanol +water) 5787.05

Recycled for next

batch

3 Methanol 2777.8 Ethyl acetate (recovered) 1134.25 Recycled

4 Water 2777.8 Distillation resisdue 27.8 To Incinaration

5 Sodium

hydroxide 92.6 Solid waste 55.55 To TSDF

6 Ethyl acetate 1157.4 Process loss 18.5

7 Charcoal 46.3

0

8 Hyflow 46.3

0

Total 7523.15

7523.15

6.0 1,2;5,6-D-mannitol (Diacetone-D-mannitol)


Acetone is reacted with D-mannitol in presemce of molten Zinc Chloride to get the title

compound. The acetone is recovered and the product is purified by crystalisation from pet

Ether . The hydrated zinc chloride is regenerated and recycled.

Chemical Reaction:

OH

OH

OH H

OH H

H OH

H OH

O

O

O H

OH H

H OH

H O

CH3

CH3

CH3

CH3

CH3

CH3

O+Anhy. ZnCl2

d Mannitol Acetone 1,2:5,6-Di-O-isopropylidene-D-mannitol

-- ZnCl2.2H2O

136.35

172.35

Mass Balance:

Sr.

No


Kgs Kgs

1 D-Mannitol 182.00 1,2:5,6-Di-O-isopropylidene-D-

mannitol 250.00

Product

2 Acetone 1820.00 Acetone (recovered) 1680.00 recycled

3 Zinc chloride 272.70 Zinc chloride hydrate 344.00 recycled

4 Ether 500.00 Ether (recovered) 475.00 recycled

5 charcoal 10.00 Solid waste 22.70 To TSDF

6 Hyflow 10.00 Process loss 23.00

7 Water (washing) 3100.00 Aqueous effluent 3100.00 To ETP

Total 3394.70 3394.70

7.0 1-Benzyl -3-Piperidone


N-Benzylglycine ethyl ester is reacted with 4-chloerbutryl chloride by refluxing in toluene

give dicarbethoxy intermediate, the dicarbethoxy intermediate is cyclised to 1-benzyl-4-

carbethoxy-3-piperidone which is on decarboxylation gives 1-benzyl-3-piperidone.

Chemical Reaction:

NHOC2H5

O+ Cl OC2H5

O

Na2CO3

KI TOLUENE

N

COOEt

COOEt

N COOEt

ONa

N

O

IPA,HCl,Toluene, Acetone

NaOC2H5, Toluene

N-Benzylglycine ethyl ester Ethyl 4-chlorobutyrate

1-Benzyl -3-Piperidone

Mass Balance:

Sr.

No


kgs kgs

1 N-Benzylglycine ethyl ester 591.25 1-Benzyl-3-piperIdone 250.00 Product

2 Ethyl 4-chlorobutyrate 494.50 Toluene (recovered) 7475.00 Recycled

3 Sodium carbonate 391.78 Acetone (recovered) 200.00 Recycled

4 Toluene 5765.00 Aqueous Effluent 6900.00 To ETP

5 Potassium iodide 1085.00 Carbon dioxide gas 157.50

6 water 4030.00 Solid waste 62.50 To TSDF

7 Sodium ethoxide, powder 203.05 Process loss 37.50

8 Hydrochloric acid, c.p. 945.00

9 Ammoniumhydroxide, c.p. 930.00

10 Acetone 220.68

11 Hydrochloric acid in IPA

5.9N 426.25

12 Carbon 25.00

13 hyflow 25.00

Total 15082.50 15082.50

8.0 1-Pyrrolidinecarbothioic acid, ammonium salt


Charge reactor with Methanol and of Carbon disulfide. Cool and add solution of Pyrrolidine

in Methanol During this addition precipitate is formed, now Add Ammonia and Stir

overnight,. Filter product and wash Methanol and Petroleum ether, Dry at room

temperature.

Chemical Reaction:

N

SNH4S

NH

+ CS2

NH4OH

--H2O

pyrrolidine

1-Pyrrolidinecarbodithioic acid ammonium salt

Mass Balance:

Sr.

No


Kgs Kgs

1 Carbon disulfide

46.92

1-Pyrrolidinecarbothioic acid,

ammonium salt 100

Product

2 Pyrrolidine 43.82 Methanol (recovered) 459.88 recycled

3 Methanol 462.96 Pet Ether (recovered) 58.64 recycled

4 Ammonia-25 % 79.02 Aqueous effluent 1346.28 To ETP

5 Petroleum ether 123.46 Solid waste 6.18 To TSDF

6 Water 1208.64

7 carbon 3.08

8 Hyflow 3.08

Total 1970.98 1970.98

9.0 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane


Fluoro benzene is reacted with 4-Chlorobutonyl chloride in dichloromethane and Aluminium

Chloride to get Fluoro Chloro Ketone , This was then reacted with ethylene glycol and

trimethylorthoformate in presence of p-toluene sulphonic acid to get 2-(3-Chloropropyl)-2-

(4-fluorophenyl)-1,3-dioxolane.

Chemical Reaction:

F

COOHCl+AlCl3 Dichloromethane

F

O

Cl

OH

OH

Trimethylorthoformate--CH3OH

--H2O

F

O O

Cl

Fluorobenzene 4-Chlorobutonylchloride

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane

-Aq AlCl3 -HCl

p-Toluenesulphonic acid

Mass Balance:

Sr.

No


Kgs Kgs

1 Fluorobenzene 106.68 2-(3-Chloropropyl)-2-(4-

fluorophenyl)-1,3-dioxolane 250 Product

2 4-chlorobutonyl chloride 135.55 Dichloromethane 827.78 Recycled

3 Aluminium chloride 147.78 Toluene 994.45 Recycled

4 Dichloromethane 833.33 Methanol 106.68 Recovered

5 Ethylene glycol 68.9 Aq aluminium chloride solution 833.33 By product

6 Trimethyl orthoformate 117.78 Aqueous effluent 1944.48 To ETP

7 Toluene 888.9 Solid waste 25 To TSDF

8 p-toluenesulphonic acid 14.68 Process Loss 21.23

9 Water 2666.68

10 Carbon + hyflow 22.67

Total 5002.95 5002.95

10. 2,2,6,6-Tetramethyl-3,5-heptanedione


sodium hydride is slurried in 1,2-dimethoxy ethane to this solution ethyl pivalate and 3,3-

dimethyl butanone is added and solution is refluxed overnight, the reaction mixture cooled

to room temp and to solution water and sulfuric acid is added, the acidic solution is then

neutralized with sodium hydroxide and the oily product is then extracted with hexane ,

hexane is recovered and product is purified by distillation.

Chemical Reaction:

CH3

CH3CH3

OC2H5

O

+

CH3

CH3CH3

CH3

ONaH 1,2-dimethoxy ethane

CH3

CH3

CH3

CH3

CH3CH3

O O

--C2H5OH

H2O

-NaOH,-H2

1

2 H2SO4

Ethylpivalate 3,3-dimethyl butanone 2,2,6,6-Tetramethyl-3,5-heptanedione

Mass Balance:

Sr.

No


Kgs Kgs

1 sodium hydride 16.1 2,2,6,6-Tetramethyl-3,5-

heptanedione

100 Product

2 1,2-dimethoxy ethane 436.24 Hexane (recovered) 664.42 Recycled

3 ethyl pivalate 87.24 1,2-dimethoxy ethane 432.48 Recycled

4 3,3-dimethyl butanone 67.12 Ethyl alcohol 30.56 Recycled

5 sulfuric acid 65.78 Disove salt Sodium sulphate 95.3 To ETP

6 sodium hydroxide 26.84 Aqueous Effluent 1170.4 To ETP

7 Hexane 671.14 Solid waste 14.75 To TSDF

8 Charcoal 6.72 Process loss 14.25

9 Hyflow 6.72

10 Water 1138.26

Total 2522.16 2522.16

11. 2,2-Bithiophene


2-bromothiophen is reacted with magnesium turning in tetrahydrofurane to prepare

Grignard reagent which was then condensed with 2-bromothiophene in presence of nickel

catalyst , after completion of reaction catalyst is filtered and the tetrahydrofurane is then

recovered to solid water is added and the product is extracted with dietyl ether.

Diethylether is recovered and product is crystalised from ethanol.

Chemical Reaction:

SBr

Mg

THFS

MgBr+

SBr

S S

Ni catlyst+ MgBr2

2-bromothiophene 2,2-bithiophene

Mass Balance:

Sr.

No


Kgs Kgs

1 2-bromothiophene 210.32 2,2-bithiophene 200 Product

2 Magnesium 30.96 Tetrahydrofurane(recovered) 3070.96 Recycled

3 Tetrahydrofurane 3096.76 Ethanol (recovered) 496.8 Recycled

4 Ni catalyst 2.08 Diethylether(recovered) 619.2 Recycled

5 Diethyl ether 645.2 Aqueous Effluent 1354.8 To ETP

6 water 1290.24 Ni catalyst 2.08 Recycled

7 Ethanol 516 Process loss 47.72

Total 5791.56 5791.56

12. 2,3-Benzofuran


o-Hydroxy benzaldehyde is reacted with Chloroacetic acid in presence of sodium hydroxide

to give o-Formylphenoxyacetic acid, this was then refluxed in mix of acetic acid and acetic

anhydride to give 2,3-Benzofuran.

Chemical Reaction:

OH

CHO

+ ClCH2COOH

NaOHCHO

OCH2COOH

O

ACETIC ACID

ACETIC ANHYDRIDE

-CO2

-H2O

-NaCl -H2O

2-Hydroxy benzaldehyde

2,3-Benzofuran

o-Formylphenoxyacetic acid

Mass Balance:

Sr.

No


Kgs Kgs

1 2-hydroxy

benzaldehyde 206.78

2,3-benzofurane

200.00

Product

2 Chloroacetic acid 160.17 Acetic acid(recovered) 1338.98 Recycle

3 Sodium hydroxide 67.80 Sodium chloride 99.16 Dissolved salt to ETP

4 Acetic acid 677.97 Carbondioxide gas 74.58

5 Acetic anhydride 677.97 Aqueous effluents 1908.48 To ETP

6 Carbon 16.95 Solid waste 33.90 To TSDF

7 hyflow 16.95 Process loss 16.94

8 water 1847.46

Total 3672.04 3672.04

13. 2,5-Bis(chloromethyl)-p-xylene


The p-xylene , formaldehyde and toluene is charged in to the reactor and cooled to 0 C, the

hydrogen chloride gas was passed at constant rate for 24 hrs , the crystalline product

separates out is filtered and the mother liquor was further mixed with xylene and

formaldehyde and reacted in above manner again and again.

Chemical Reaction:

CH3

CH3

+ HCHO HCl+

CH3

CH3

Cl

Cl

Toluene

--H2O

p-Xylene 2,5-Bis(chloromethyl)-p-xylene

Mass Balance:

Sr.

No


Kgs Kgs

1 p-Xylene 113.98 2,5-Bis(chloromethyl)-p-xylene 200.00 Product


3 HCl Gas 76.34 Toluene Mother liquor 618.30 Recycle

4 paraformaldehyde 64.52

5 water (washing ) 1500.00

Total 2357.00 2357.00

14. 2-Acetyl Cyclohexanone


Cyclohexanone is reacted with pyrrolidine in toluene using p-toluenesulphonic acid as

catalyst to get Eanamine , This was refluxed with Acetic anhydride in toluene to get the 2-

acetyl cyclohexanone , the Toluene is recovered and final product is purified by distillation.

Chemical Reaction:

O

+NH

CH-

N+ CH3

O

CH3

O

O

+

O

CH3

O

TolueneToluene

cyclohexanone PyrrolidineAcetic anhydride

2-acetyl Cyclohexanone

Mass Balance:

Sr.

No


Kgs Kgs

1 cyclohexanone 175.00 2-acetyl cyclohexanone 250.00 Product

2 Pyrrolidine 126.78 Toluene (recovered) 794.65 Recycled

3 Toluene 892.85 Pyrrolidine (Recovered) 116.08 Recycled

4 Acetic anhydride 182.15 Distillation residue 25.00 To incineration

5 Water 1892.85 Aqueous effluent 2083.93 To ETP

Total 3269.63 3269.65

15. 2-Aminopyrazine


The 2-chloropyrazine and methanol is fed in to autoclave and the ammonia gas is purged till

5 kg pressure and autoclave is heated to 100 C, on cooling the methanol is recovered and

product is crystaliased from ethyl acetate.

Chemical Reaction:

N

N Cl

NH3

Methanol

N

N NH2

2-chloropyrazine 2-aminopyrazine

NH4Cl+

Mass Balance:

Sr.

No


Kgs Kgs

1 2-chloropyrazine 346.67 2-Amino pyrazine 250.00 Product

2 Ammonia gas 113.33 Methanol(recovered) 2633.33 Recycled

3 Methanol 2666.67 Ethyl acetate(recovered) 1633.33 recycled

4 Ethylacetate 1666.67 Solid waste 83.33 To TSDF

5 carbon 33.33 Distillation residue 43.33 To Incinaration

6 Hyflow 33.33 Ammonium chloride 180.00 Disolve salt to ETP

7 Water (washing) 1833.33 Aq effluent 1833.33 To ETP


Total 6693.33 6693.33

16. 2-Bromo-p-xylene


Excess of p-xylene is reacted with bromine in presence of Ferric chloride in cold to give 2-

bromo-p-xylene , the crude product is purified by distillation.

Chemical Reaction:

CH3

CH3

CH3

CH3

Br

p-Xylene 2-Bromo-p-xylene

Br Br

--HBr

Mass Balance:

Sr.

No


Kgs Kgs

1 p-Xylene 464.90 2-bromo-p-xylene 250.00 Product

2 Bromine 233.93 Hydrogen bromide gas 116.95 To scrubber

3 Ferric chloride 2.20 p-xylene (recovered) 301.18 Recycled

4 Water (washing) 1250.00 Distillation residue 27.90 To incineration

5 Process loss 5.00

6 Aq effluent (washing ) 1250.00 To ETP

Total 1951.03 1951.03

17. 2-Iodoethanol


2-chloroethanol is reacted with sodium iodide in refluxing acetone , the precipitated sodium

chloride is filtered ,solvent is recovered and the product is purified by distillation.

Chemical Reaction:

Cl

OH

+ NaIAcetone

NaClI

OH +

2-Chloroethanol 2-Iodoethanolsodium iodide

Mass Balance:

Sr.

No


Kgs Kgs

1 Sodium iodide 292.40 2-iodoethanol 300.00 Product

2 2-chloroethanol 155.93 Acetone (recovered) 1533.33 Recycled

3 Acetone 1566.13 Sodium chloride 111.13 Dislove Salt to ETP

4 Water (washing) 1000.00 Distillation residue 46.67 To incinaration

5 Process loss 23.33

6 Aq Effluent ( From washing) 1000.00 To ETP

Total 3014.47 3014.47

18. 2-Methoxy hydroquinone


Vanilline is dissolved in sodium hydroxide and water and oxidized with hydrogen peroxide to

corresponding product, the reaction mass is neutralized with dilute hydrochloric acid and

product is extracted with ethyl acetate , ethyl acetate is recovered and product is

recrystalised from toluene.

Chemical Reaction:

OH

CHO

OCH3

H2O2 NaOH HCl

-NaCl OH

OH

OCH3

Vaniline 2-Methoxyhydroquinone

1 2

--H2O

Mass Balance:

Sr.

No


Kgs Kgs

1 Vaniline 118.76 2-

Methoxyhydroquinone

100 Product

2 Hydrogen peroxide 26.56 Sodium chloride 45.32 Dissolved salt to ETP

3 Water 968.76 Ethyl acetate

(Recovered)

1085.92 Recycled

4 Sodium hydroxide 31.24 Toluene(Recovered) 542.96 Recycled

5 Hydrochloric acid 93.76 Aq Effluent 1105.48 To ETP

6 Ethyl acetate 1093.76 Solid waste 15.64 To TSDF

7 Toluene 546.88

8 Carbon 7.8

9 Hyflow 7.8

Total 2895.32 2895.32

19. 2-Quinoline caerboxaldehyde


Quinaldine is reacted with selenious acid in 1,4-dioxane the precipitated selenium is filtered

off , and 1,4-dioxane is recovered and reused, the crude product washed with water and

further treated with charcosl recrystalised from ethyl acetate to get pure product.

Chemical Reaction:

N CH3

N CHO

H2SeO3

1,4-DIOXANE

+ Se

Mass Balance:

Sr.

No

INPUT Qty

Kgs.

Output Qty

Kgs.

Remark

1 Quinaldine 91.00 2-Quinoline carboxaldehyde 100.00 Product

2 1,4-dioxane 400.00 Selenium powder 49.60 Reprocess and reuse

3 Selenious acid 141.40 1,4-dioxane (recovered) 392.00 Reuse

4 water 1000.00 Distillation residue 7.60 Incineration

5 Carbon 4.00 Aqueous effluent 1083.20 To ETP

6 hyflow 4.00 Solid waste(carbon+hyflow) 8.00 To TSDF

Total 1640.40 1640.40

20. 3,3,5,5-tetramethylcyclohexanone


The Isophorone is treated with methyl magnesium bromide in dry ether using cuprous

acetate as catalyst at 0-5 C. The reaction mass is treated with Dilute Hydrochloric acid , the

ether is recovered and product is purified by distillation.

Chemical Reaction:

CH3CH3

CH3

O

+ CH3MgBr

Ether

CH3

CH3CH3

CH3

O

Isophorone MethylMagnesiumbromide 3,3,5,5-tetramethylcyclohexanone

Mass Balance:

Sr.

No


Kgs Kgs

1 Methyl Mganesium

bromide

212.50 3,3,5,5-

tetramethylcyclohexanone

250.00 Product

2 Ether 2125.00 Ether (recovered) 1991.05 Recycled

3 Isophorone 246.45 Waste water 1214.30 To ETP

4 Hydrochloric Acid 98.20 Process loss 113.40

5 Cuprous Acetate 2.70 Solid waste 8.95 To CSWD

6 Water 892.85

Total 3577.70 3577.70

21. 3,5-Pyrazoledicarboxylic acid


Hydrazine sulphate, sodium hydroxide is dissolved in water and cooled , to this cold solution

acetyl acetone is added and sitter overnight at room temperature, the water is added and

the product is extracted with diethyl ether, the solvent is recovered the crude product is

isolated , to this crude product is dissolved in water and oxidized with hydrogen peroxide ,

after completion of reaction the water is distilled out the precipitated product is slurred in

Acetone filter and dry in vacuum oven.

Chemical Reaction:

CH3CH3

O O

+ NH2NH2.H2SO4NaOH H2O

-Na2OS4N

NH

CH3

CH3

N

NH

COOH

HOOC

H2O2-H2O

Acetyl acetone Hydrazine3,5-Dimethylpyrazole

3,5-Pyrazoledicarboxylic acid

Mass Balance:

Sr.

No INPUT Qty. Output Qty.

Remark

Kgs

Kgs

1 Acetyl acetone 144.92

3,5-

Pyrazoledicarboxylic

acid

200 Product

2 Sodium hydroxide 57.98 Sodium sulphate 205.8 Dissolved salt to ETP

3 Hydrazine sulphate 188.4 Acetone (Recovered) 420.28 Recycled

4 Hydrogen peroxide 65.22 Aq effluent 1789.86 To ETP

5 acetone 434.78 Solid waste 28.98 To TSDF

6 Water 1724.64 Process loss 0

7 Carbon+hyflow 28.98

0

Total 2644.92

2644.92

22. 3-hydroxy-1,2,3,4-tetrahydrofuran


1,2,4-trihydroxybutane and p-toluenesulfonic acid monohydrate. are added, contents are

heated, with stirring to 220 C, the water formed is distiiled out and final product is purified

by vacuum distillation.

Chemical Reaction:

OH

OH

OHp-TsOH 220 C

-H2OO

OH

1,2,4-trihydroxybutane 3-hydroxy-1,2,3,4-tetrahydro Furan

Mass Balance:

Sr.

No


Kgs Kgs

1 1,2,4-

trihydroxybutane

130.86 3-hydroxy-1,2,3,4-tetrahydro

Furan

100.00 product

2 p-tolune sulphonic

acid

1.24 Effluent 20.98 To ETP

3 Water (washing ) 1000.00 Distillation residue 6.18 To

Incinaration

4 Aqueous Effluent 1000.00 To ETP

5 Process loss 4.94

Total 1132.10 1132.10

23. 4,4′-Di-tert-butylbiphenyl


The Biphenyl is dissolved in nitromethane and treated with aluminum chloride an tert butyl

chloride at 0 C the precipitated product is filtered and recrystalised from hexane . the

nitromethane is recycled as it is for nest batch without recovery.

Chemical Reaction:

Cl

CH3

CH3

CH3+CH3

CH3CH3

CH3

CH3

CH3

Biphenyl Tert-Butyl chloride4,4-Di-tert-butylbiphenyl

AlCl3

Mass Balance:

Sr.

No


Kgs Kgs

1 Biphenyl 192.50 4,4′-Di-tert-butylbiphenyl 250.00 product

2 Nitromethane 1922.50 Nitromethane (recovered) 1940.00 recycled

3 Aluminium

chloride

105.00 Hexane (recovered) 1225.00 recycled

4 Hexane 1250.00 Distillation residue 75.00 To incinaration

5 Tert-butyl

chloride

117.50 Solid waste (carbon ,hyflow) 22.50 To TSDF

6 Water (washing) 1000.00 Process loss 75.00

Aqueous Effluent (from

washing )

1000.00 To ETP

Total 3587.50 3587.50

24. 4,6-Diamino-2-mercaptopyrimidine


Sodium methoxide is added to methanol followed by addition Thiourea followed by addition

of malanonitrile, the mixture is refluxed overnight , the reaction mixture is neutralized by dil

Hydrochloric acid in cold and the precipitated product is filtered and washed with acetone ,

the crude product is recrystalised from acetone.

Chemical Reaction:

NH2

NH2

S

+ CN

NC CH3ONa Methanol HCl

--NaCl

N

NNH2

NH2

SH

Thiourea Malononitrile4,6-Diamino-2-mercaptopyrimidine

Mass Balance:

Sr.

No


Kgs Kgs

1 Thiourea 133.80 4,6-Diamino-2-

mercaptopyrimidine,

hemihydrate

250.00 Product

2 Malanonitrile 116.20 Methanol (Recovered) 1355.63 Recycled

3 Sodium methoxide 95.08 Acetone (Recovered) 862.68 Recycled

4 Methanol 1338.03 Sodium chloride 102.13 Dissolve slat to ETP

5 Acetone 880.28 Aqueous Effluent 1232.40 To ETP

6 Hydrochloric acid 213.03 Solid waste 17.60 TO TSDF

7 water 1056.35 Process loss 29.93

8 Carbon+Hyflow 17.60 0.00

Total 3850.35 3850.35

25. Biphenyl-4-carbonyl chloride


A solution of biphenyl- 4- carboxylic acid and N,N-dimethylforamide in thionyl chloride was

stirred under reflux for 3h. After cooling at room temperature, the mixture was

concentrated in vacuum to give biphenyl-4- carbonyl chloride as a colorless solid.

Chemical Reaction:

O OH

+ SOCl2

O Cl

HCl SO2+ +

Biphenyl-4-carboxylic Acid Biphenyl-4-carbonyl chloride

Mass Balance:

Sr.

No


Kgs Kgs

1 biphenyl- 4- carboxylic acid 98.50 Biphenyl-4-carbonyl

chloride

100.00 Product

2 Thionyl chloride 119.40 Thionyl chloride 60.72 recycled

3 N.N-Dimethyl formamide 0.74 Sulphurdioxide gas 31.84 To scrubber

4 Water (washing ) 1500.00 Hydrogen chloride gas 18.64 To scrubber

Distillation Residue 7.44 To incinaration

Aq Effluent (from

washing )

1500.00 To ETP

Total 1718.64 1718.64

26. 4-Cyano-4-phenylpiperidine hydrochloride


N-(2-hydroxyethyl)-N-benzylmethylamine is chlorinated with Thionyl chloride in Chlorofom

at reflux temperature , the chlorinated product so obtained is condensed with Benzyl

Cyanide in presence of sodium Hydroxide to get N-benzyl -4-cyano-4-phenyl piperdine, the

N-benzyl -4-cyano-4-phenyl piperdine is Debenzylated in Toluene with Palladium Charcoal

and isolated as hydrochloride salt with isopropyl alcohol and hydrochloric acid.

Chemical Reaction:

N

CH2CH2OH

CH2CH2OH

SOCL2 CHLOROFORMN

CH2CH2Cl

CH2CH2Cl

NCN

NaOH

Toluene

CN

- NaCl

-H2O

-SO2 -HCl

NH

CN. HCl

Pd/C Toluene IPAHClH2 Gas

N-(2-hydroxyethyl)-N-benzylmethylamine

4-Cyano-4-phenylpiperidine hydrochlorideN-Benzyl-4-Cyano-4-phenylpiperidine hydrochloride

Mass Balance:

Sr.

No


Kgs Kgs

N-(2-hydroxyethyl)-N-

benzylmethylamine 219.60

4-Cyano-4-phenylpiperidine

HCl 250.00

Product

chloroform 2364.88 Chloroform (Recovered) 2353.60 Recycled Thionyl chloride 270.28 Toluene (Recovered) 1227.48 Recycled Sodium sulphate 11.25 Isopropyl alcohol (Recovered) 2241.00 Recycled Benzyl cyanide 131.75 Acetone(Recovered) 777.03 Recycled Sodium hydroxide 90.10 Dichloromethane (Recovered) 2241.00 Recycled Toluene 1238.75 SO2 gas 144.15 To scrubber

Acetone 788.30 HCl Gas 82.20 To scrubber Isopropanol 2252.25 Pd/C 11.25 To regeneration Pd/C 11.25 Solid wasre 39.43 To TSDF

Dichloromethane 2252.25 Aq Effluent 2550.68 To ETP

Hydrogen 45.05 Sodium chlorie 131.75 Dissolved salt to ETP Water 2252.25 Process loss 37.15 Hydrochloric acid 136.25 0.00 Carbon 11.25 0.00

Hyflow 11.25 0.00 Total 12086.70 12086.70

27. 4-Quinoline carboxaldehyde


Lepidine is reacted with selenious acid in 1,4-dioxane the precipitated selenium is filtered

off , and 1,4-dioxane is recovered and reused, the crude product washed with water and

further treated with charcosl recrystalised from ethyl acetate to get pure product.

Chemical Reaction:

N

CH3

N

CHO

H2SeO3

1,4-DIOXANE

+ Se

Lepidine4-quinolinecarboxaldehyde

Mass Balance:

Sr.

No

INPUT Qty

Kgs.

Output Qty

Kgs.

Remark

1 lepidine 91.00 4-Quinoline carboxaldehyde 100.00 Product

2 1,4-dioxane 400.00 Selenium powder 49.60 Reprocess and reuse

3 Selenious acid 141.40 1,4-dioxane (recovered) 392.00 Reuse

4 Water 1500.00 Distillation residue 7.60 Incineration

5 Carbon 4.00 Aqueous Water 1583.20 To ETP

6 hyflow 4.00 Solid waste(carbon+hyflow) 8.00 To TSDF

Total 1740.40 1740.40

28. 4-tert-Butylcalix[4]arene-tetraacetic acid tetraethyl ester


p-tert Butyl Phenol is reacted with formaldehyde in Toluene, the toluene is recovered and

then Diphenyl ether is added, refluxed for overnight, cooled the Precipitated product is

filtered, To this product is added acetone stirred, there after anhydrous potassium

carbonate and bromoethyl acetate is added, refluxed overnight, precipitated potassium

bromide is filtered off, acetone is recovered and the product is crystalised from Ethyl

alcohol.

Chemical Reaction:

CH3

CH3

CH3

CH3CH3

CH3

CH3

CH3

CH3

CH3 CH3

CH3

OH

OH

OH

OH

T-butylcalix[4]arene

CH3 CH3

CH3

OH

NaOH

+ HCHO

Diphenyl oxide

BrCH2COOC2H5

K2CO3 Acetone

CH3

CH3

CH3

CH3CH3

CH3

CH3

CH3

CH3

CH3 CH3

CH3

CH2CO2Et

CH2CO2Et

CH2CO2Et

EtO2CH2C

4-tert-Butylcalix[4]arene-tetraacetic acid tetraethyl ester

Reflux

4 - tert Butyl phenol

4 4

Mass Balance:

Sr.

No


Kgs Kgs

1 p-tert butyl phenol

357.50

4-tert-Butylcalix[4]arene-

tetraacetic acid tetraethyl ester 500.00

Product

2 Formaldehyde 64.50 Toluene (Recovered) 3125.00 Recycled

3 Bromo ethyl

acetate 359.50

Acetone (Recovered)

3900.00

Recycled

4 Potassium

carbonate 297.00

Ethanol(Recovered)

3700.00

Recycled

5 Toluene 3200.00 Diphenyl ether(Recovered) 3175.00 Recycled

6 Acetone 4000.00 Aqueous Effluent 4150.00 To ETP

7 Ethanol 3750.00 Carbon dioxide 95.00 To scrubber

8 Diphenyl ether 3200.00 Potassium bromide 258.50 To be Sold

9 Water 3750.00 Solid waste 100.00 To TSDF

10 carbon 50.00 Process loss 75.00

11 hyflow 50.00 0.00

Total 19078.50 19078.50

29. 5,6-Dimethoxy-1-Indanone

Manufacturing process:

3,4-Dimethoxy benzaldehyde is condensed with Malonic acid in presence of pyridine ,

further it was reduced to 3,4-dimethoxy benzene propionic acid using Pd/C as catalyst , This

is then cyclised to 5,6-dimethoxy -1-indanone with aluminium chloride using

Dichloromethane as solvent.

Chemical Reaction:

O

O

CH3

CH3

O

H

O

O

CH3

CH3

COOH

O

O

CH3

CH3

COOH O

O

CH3

CH3

O

O

OHO

OH

+PYRIDINE

CH3OH

Pd/C

H2

AlCl3, DICHLOROMETHANE

--H2O -AlCl3

-CO2 --H2O

varatrole Malonic Acid

5,6-dimethoxy-1-Indanone

Mass Balance:

Sr.

No


Kgs Kgs

1 5,6-dimethoxy benzaldehyde 482.46 5,6-dimethoxy-1-indanone 500 PRODUCT

2 Malonic acid 302.32 Pyridine (Recovered) 1569.78 Recycled

3 Pyridine 1613.38 Methanol (Recovered) 5668.6 Recycled

4 Methanol 5813.96 Carbondioxide 127.9 5 Pd/C 29.08 Pd/C (regenretaed) 29.08 Recycleged

6 Dichloromethane

5232.56

Dichloromethane

(Recovered) 5087.2

Recycled

7 Aluminium chloride 154.08 Aqueous effluent 6540.7 To ETP

8 Ethylacetate 3488.38 Ethylacetate (Recovered) 3406.98 Recycled

9 water 5813.96 Solid waste 87.2 To TSDF

10 Carbon 29.08 0

11 Hyflow 58.16 0

Total 23017.42 23017.42

30. Burgess reagent


Chlorosulfonyl isocyanate is reacted with methanol in toluene to get intermediate

compound which was in situ reacted with Triethyl amine to get crystalline burgess salt

which was isolated by filtration and the mother liquor was recycled for Next Batch.

Chemical Reaction:

S NCOCl

O

O

S NHCl

O

O OCH3

O

+ N C2H5

H5C2

H5C2

CH3OHS

-N

O

O OCH3

O

N+

H5C2

H5C2

H5C2

Toluene --HCl

Chlorosulfonyl Isocyanate Triethylamine Burgess Reagent

Mass Balance:

Sr.

No


Kgs Kgs

1 Chlorosulfonylisocyanate 156.68 Burgess reagent 250.00 Product

2 Methanol 35.55 Toluene (recovered) 544.45 Recycled

3 Toluene 555.55 Aqueous effluent (from

washing) 1750.55 To ETP

4 Triethylamine

112.23

Hydrogen chloride gas

40.00

To

scrubber

5 Water (washing) 1750.55 Process Loss 12.23

6 0.00 Solid waste 13.33 To TSDF

Total 2610.55 2610.55

31. 2-Methylglutaric acid


Diethyl Malonate is reacted with Methylmethacrylate. In presence of sodium methoxide

and followed by hydrolysis and decarboxylation gives 2-methylglutaric acid.

Chemical Reaction:

H3CO OCH3

O O+ OCH3

CH2

CH3

O

OH OH

OO

CH3NaOCH3

HCl H2O

- CO2 -NaCl

DimethylMalonate

2-Methylglutaricacid

Methylmethacrylate

Mass Balance:

Sr.

No


Kgs Kgs

1 Dimethylmalonate 244.45 2-Methylglutaric acid 250.00 Product

2 Methylmethacrylate 185.19 Methanol (recovered) 2333.36 Recycled

3 Sodium methoxide 100.00 Sodium chloride 107.41 Desolve salt to ETP

4 Hydrochloric acid 185.19 Aqueous effluent 1000.01 To ETP

5 Methanol 2222.25 Carbondioxide 162.96

6 Water 925.94 Solid waste 27.78 TO TSDF

7 Charcoal/Hyflow 18.53 0.00

Total 3881.53 3881.53

32. Methylthiazolyldiphenyl-tetrazolium bromide


The methyl ethyl ketone is brominates with bromine to get bromocompound, which is on

reaction with Thiourea gives thiazole derivative, the thiazole derivative is condensed with

benzaldehydephenyl hydrazone to get title compound Methylthiazolyldiphenyl-tetrazolium

bromide.

Chemical Reaction:

CH3

CH3

OBr2 CH3

CH3

O

Br

+ NH2

NH2

S

N

S

NH2CH3

CH3

NS

NH2

CH3

CH3

+ N

NH

-HBr

HBr

N N+

N N

N

S

CH3

CH3

Br-

Methylethylketone

Benzaldehydephenyl hydrazone

Methylthiazolyldiphenyl-tetrazolium bromide

ethylene dichloride

-

Methanol

Mass Balance:

Sr.

No


Kgs Kgs

1 Methylethylketone 18.32 Methylthiazolyldiphenyl-

tetrazolium bromide

100.00 Product

2 Bromine 40.46 Methanol (Recovered ) 184.48 Recycled

3 Thiourea 19.34 Hydrogen bromide gas 20.36 To

scrubber

4 Ethylene dichloride 183.20 Ethylene dichloride (Recovered) 178.12 Recycled

5 Benzaldehydephenyl

hydrazine

49.88 Aqueous effluent 2330.78 To ETP

6 Methanol 190.84 Process loss 6.36

7 Water 2318.06

Total 2820.10 2820.10

33. Dipropyl phthalate


Propanol is reacted with phthalic anhydride in refluxing toluene using P-touene sulphonic

acid as catalyst. Toluene is recovered and product is purified by distillation.

Chemical Reaction:

O

O

O

+ OHCH3

PTSA O

O

O

O

CH3

CH3

Phthalic anydride PropanolDipropylpthalate

Toluene

--H2O

Mass Balance:

Sr.

No


Kgs Kgs

1 Phthalic anhydride 155.45 Dipropyl phthalate 250 Product

2 2-propanol 126.05 Toluene(Recovered) 882.35 Recycled


4 p-Toluenesulphonic

acid

1.575 Distillation residue 15.75 To Incinaration

5 Water (washing) 2012.6 Loss due to evaporation 4.2

Total 4438.55 2438.55

34. Copolymer methylstyrene-chloroacrylate


Chloroalphamethylacrylate is reacted with alpha methylstyrene in Methanol using AIBN as

catalyst. The methanol is recovered and the water is added to residue to decompose the

complex and precipitate the product which was recrystalised from boiling Methanol.

Chemical Reaction:

Cl

CH2

OCH 3

O

+

CH2

CH3

Methaol

AIBN

Copolymer Methyl styrene Chloroacrylate

Mass Balance:

Sr.

No


Kgs Kgs

1 Alphamethyl

chloroacrylate 252.10 CopolymerMethyl styreneChloroacrylate 500.00 Product

2 Alphamethyl styrene 247.90 Methanol (recovered) 2479.00 Recycled

3 Methanol 2521.00 Soid waste 21.00 To TSDF

4 AIBN 0.20 Aqueous effluent (from washing) 2050.43 To ETP

5 Water (for Washing) 2050.43 Process loss 21.23

Total 5071.65 5071.65

35. Benzethonium Chloride


Digol is reacted with Thionyl Chloride to get Bischlorethylether, this was then condensed

with p-tert butyl phenol using Sodium hydroxide, the condensed product is reacted with

Methanolic dimethyl amine, The condensed amine product is then conerted in to

Benzethonium chloride using benzyl chloride and methyl ethyl ketone.

Chemical Reaction:

OOH OH + SOCl 2 O

Cl Cl +OH

CH3

CH3

CH3

CH3

CH3

NaOH

CH3

CH3

CH3

CH3

CH3O

OCl

NH CH3

CH3

Methanol

CH3

CH3

CH3

CH3

CH3O

ON

CH3

CH3

Cl

MEK

CH3

CH3

CH3

CH3

CH3O

ON

+

CH3

CH3 Cl-

Digol BischloroethyletherThionyl Chloride Octylphenol

Benzyl Chloride

Benzethonium chloride

Mass Balance:

Sr.

No


Kgs Kgs

1 Digol 124.70 Benzethonium chloride 500.00 Product

2 Thionyl Chloride 277.64 Hexane (recovered) 858.82 Recycled

3 P-tert octyl phenol 242.36 Methanol (recovered) 1141.18 Recycled

4 Hexane 882.36 Methylethylketone (recovered) 894.12 Recycled

5 Dimethylamine 52.94 Sodium chloride 68.24 Salt recycled in brine

6 Methanol 1176.48 Hydrogen chloride gas 85.88 To scrubber

7 Benzyl chloride 148.24 Aqueous Effluent 3382.36 To ETP

8 Methylethylketone 941.18 Solid waste 41.18 To TSDF

9 Water 3176.48 Process loss 80.00

10 Charcoal+hyflow 29.42

Total 7051.76 7051.76

36. DiphenylIodonium Nitrate


Acetic Acid is mixed with sulfuric acid and to the mixture is added benzene, cooled to zero

degree and added sodium iodate, the whole mixture is stirred at room temperature for 72

hrs and again cooled to zero degree followed by addition of acetic anhydride and then

sodium nitrite , again warmed to room temperature and stirred for 2 days , where upon

solid product separate out which is filtered and recrystalised from methanol.

Chemical Reaction:

+ NaIO3

Acetic acid I+NaO3

-

I+

NO3

-

NaNO3

Acetic anhydride

Benzene sodium iodate Diphenyliodonium nitrate-sodium acetate

Mass Balance:

Sr.

No


Kgs Kgs

1 Benzene 56.85 Diphenyl iododonim nitrate 250.00 Product

2 Sodium iodate 144.33 Sodium acetate 131.20 To be salt

3 Sodium nitrite 61.95 Methanol (recovered) 357.15 Recycled

4 Acetic acid 328.00 Aqueous effluent (mother liquor) 1725.23 To ETP

5 Acetic anhydride 87.48 Process loss 16.78

6 water 1437.33

7 Methanol 364.43

Total 2480.35 2480.35

37. Alpha Bromo Gamma Butyrolactone


Alpha Bromo Gamma butyrolactone is brominates in acetic acid with bromine at room

temperature, the acetic acid is recovered and the product is purified by vaccum distillation.

Chemical Reaction:

OO O

O

Br

Br2 Acetic acid

+ NaBr

NaOH

H2O+

Mass Balance:

Sr.

No


Kgs Kgs

1 Gamma

Butyrolactone

136.40 Alpha bromo gamma

butyrolactone

250.00 Product

2 Bromine 252.80 Sodium bromide 161.35 To be sold

3 Acetic acid 1362.50 Acetic acid (recovered) 1344.90 Recycled

4 Water (washing) 1658.20 Distillation residue 7.90 To incineration

5 Sodium hydroxide 63.25 Aqueous Effluent 1686.50 To ETP

6 0.00 Process loss 22.50

Total 3473.15 3473.15

38. Benzene seleninic anhydride


Diphenyl diselenide was treated with Hydrogen peroxide in 1,4-Dioxane at 10 C to get

benzene seleninic acid which was further refluxed in toluene to get Benzene seleninic

anhydride, the product was filotered and washed with pentane and dried in vacuum.

Chemical Reaction:

SeSe

H2O2

SeOOH

SeO

SeToluene

Reflux

Diphenyldiselenide Benzeneseleninic anhydride

Mass Balance:

Sr.

No


Kgs Kgs

1 Diphenyldiselenide 237.50 Benzene seleninic

anhydride

250.00 Product

2 1,4-dioxane 2350.00 Dioxane(recovered) 2300.00 Recycled

3 Toluene 2500.00 Water (distilled) 295.00 To ETP

4 Hydrogen peroxide 280.00 Toluene(recovered) 2450.00 Recycled

5 Water (washing ) 1250.00 Process loss 72.50

6 0.00 Aqueous effluent (from

washing )

1250.00 To ETP

Total 6617.50 6617.50

39. Bis(2-hydroxyethyl)dimethylammonium chloride


Dimethylaminoethanol in acetonitrile is reacted with 2-chloroethanol under reflux for over

night, the resulting white crystalline product filtered and washed with ether and dried under

vacuum.

Chemical Reaction:

N

CH3

CH3 OH+ Cl

OH

Acetonitrile

OHN

+

OH

CH3

CH3

Cl-

Dimethylaminoethanol 2-chloroethanol Bis(2-hydroxyethyl)dimethylammonium chloride

Mass Balance:

Sr.

No


Kgs Kgs

1 Dimethylaminoetha

nol

105.32 Bis(2-hydroxy ethyl)

dimethyl ammonium

chloride

200.00 Product

2 2-chloroethanol 94.68 Acetonitrile(recovered) 1118.36 Recycled

3 Acetonitirile 1124.28 Ether (recoverd) 100.60 Recycled

4 Ether 118.36 Process loss 23.68

5 Water (washing ) 1000.00 Aqueous Effluent (from

washing )

1000.00 To ETP

Total 2442.64 2442.64

40. Bis(phenylsulfonyl)methan


Bisphenylthiomethnane is dissolved in mix of acetic acid and acetic anhydride and cooled to

0 c, the hydrogen peroxide is added and heated to 50 C , On cooling the product is

precipitated and filtered , the mother liquor is store and used for next batch , the product is

recrystalised from Ethanol.

Chemical Reaction:

SS Acetic Acid acetic anhydride SS

O O

H2O2

Bisphenylthiomethane Bis(phenylsulfonyl)methane

Mass Balance:

Sr.

No


Kgs Kgs

1 Bisphenylthiomethane 241.65 Bis(phenylsulfonyl)methane 250.00 Product

2 Acetic acid 833.35 Acetic acid+acetic

anhydride

1062.50 Recycled

3 Acetic anhydride 208.35 Water (from washing) 1614.60 To ETP

4 Hydrogen Peroxide (30

%)

118.75 Ethanol (recovered) 1229.15 recycled

5 Water(washing) 1520.85 Solid waste 21.90 TO CSWD

6 Ethanol 1250.00 Process loss 15.65

7 Charcoal + hyfllow 20.85 0.00

Total 4193.80 4193.80

41. Bis phenylthiomethane


Thiophenol is treated with Dichloromethane and sodium hydroxide solution at 0-5 c, the

organic layer is separated and the aq. layer is sent to ETP, The dichlorometane is recovered

and crude product is isolated and purified by distillation.

Chemical Reaction:

SH

+Cl

H

Cl H

S S

THIOPHENOLBISPHENYLTHIOMETHANE

Triethyl amine

Mass Balance:

Sr.

No


Kgs Kgs

1 Thiophenol 257.50 Bisphenylthiometahne 250.00 Product

2 Triethyl amine 45.50 Triethylamine hydrochloride 61.90 Reworked and reused

3 Dichloromethane 3600.00 Dichloromethane(recovered) 3550.00 Recycled

4 NaOH 18.00 Aqueous effluent 1532.80 Sent to ETP

5 Water

1500.00

Sodium chloride

26.30

Dissolved salt sent to

ETP

Total 4421.00 4421.00

42. Calix[4]arene


The t-Butylcalix[4]arene is dissolved in dry Tolune, phenol is added and further stirred to

dissolve, Mix is cooled to 0 C and Aluninium chloride is added in portion wise at temp 0-5 C,

add water and separate the organic layer recover Toluene, and recrystalise product from

chloroform and then from Methanol.

Chemical Reaction:

CH3

CH3

CH3

CH3CH3

CH3

CH3

CH3

CH3

CH3 CH3

CH3

OH

OH

OH

OH

OH

OH

OH

OHPhenol

AlCl3 Toluene

T-butylcalix[4]arene

calix[4]arene

Mass Balance:

Sr.

No


Kgs Kgs

1 t-

butylcalix[4]arene

725.00 Calix[4]arene 500.00 Product

2 Toluene 7600.00 Chloroform (recovered) 3900.00 Recycled

3 Phenol 110.00 Methanol(recovered) 3900.00 Recycled

4 Aluminium

chloride

760.00 Toluene 7500.00 Recycled

5 Chloroform 4000.00 Solid waste 100.00 To TSDF

6 Methanol 4000.00 Aqueous Effluent 8650.00 To ETP

7 Carbon 50.00 Process loss 145.00

8 hyflow 50.00 Solid waste(carbon,hyflow) 100.00 To incineration/TSDF

9 water 7500.00 0.00

Total 24795.00 24795.00

43. Cinnamyl chloride


The Cinnamyl alcohol is reacted with Thionyl chloride in toluene using N ,N- dimethyl

formamide as catalyst, after completion of reaction the toluene is recovered and the

product is purified by distillation.

Chemical Reaction:

OH Cl

+ SOCl2

Toluene N,N-Dimethylformamide

--HCl

Cinnamyl Alcohol Cinnamyl ChlorideThionyl Chloride

Mass Balance:

Sr.

No


Kgs Kgs

1 Cinnamyl alcohol 234.28 Cinnamyl chloride 250.00 Product

2 Thionyl Chloride 206.30 Toluene (recovered) 1127.63 Recycled

3 Toluene 1136.38 HCl Gas 63.80 To scrubber

4 N N –

dimethylformamide

2.63 Sulphurdioxide gas 111.93 To scrubber

5 Water (washing ) 1625.00 Distillation residue 26.23 To Incinaration

6 Aqueous effluent 1625.00 To ETP

Total 3204.58 3204.58

44. 2-Hydroxy-4,6-dimethylpyridine-3-carbonitrile


cyanoacetamide is reacted with acetylacetone in refluxing methanol using piperdine as base

to give the crystalline product 2-Hydroxy-4,6-dimethylpyridine-3-carbonitrile which filtered

washed with methanol and dried in oven.

Chemical Reaction:

NH2

CN

O Methanol

piperdine+

CH3CH3

O O

N OH

CN

CH3

CH3

Cyanoacetamide. Acetylaceton2-Hydroxy-4,6-dimethylpyridine-3-carbonitrile

Mass Balance:

Sr.

No


Kgs Kgs

1 Cyanoacetamide

141.90

2-Hydroxy-4,6-

dimethylpyridine-3-

carbonitrile

250.00

Product

2 Acetylacetone 168.93 Methanol 1258.45 Recycled

3 Methanol 1266.90 Aqueous Effluent 1479.73 To ETP

4 Piperdine 3.05 Process loss 11.48

5 Water(washing) 1418.88

Total 2499.65 2499.65

45. cyclopropyl phenyl sulphide


Thiophenol is treated with Sodium Hydroxide in toluene to form Sodium Salt, To this is

added Cyclopropyl bromide, sodiumbromide so formed is filtered off and toluene is

recovered the product is purified by vacuum distillation.

Chemical Reaction:

SH

+

BrToluene

NaOH

S

Thiophenol Cyclopropyl Bromide Cyclopropylphenylsulphide

+ NaBr + OH2

Mass Balance:

Sr.

No


Kgs Kgs

1 Thiophenol 73.32 Cyclopropyl phenyl

sulphide

100.00 Product

2 Cyclopropyl

bromide


3 Sodium hydroxide 26.66 Aqueous Effluent 1246.66 To ETP

4 Toluene 733.32 Sodium bromide 68.00 To be sold

5 Water (cleaning) 1233.00 Process loss 4.98

Total 214630 2146.30

46. Dibenzothiophene


Biphenyl, sulphur powder and aluminium chloride is mixed together and heated till all melt

and form homogeneous mixture, on cooling the hard mass obtained was powdered and

extracted in hot toluene, the toluene is recovered , crude product is isolated and

recrystalised from hot methanol.

Chemical Reaction:

S (powder)

AlCl3 S

BiphenylDibenzothiophene

Mass Balance:

Sr.

No


Kgs Kgs

1 Biphenyl 212.50 Dibenzothiophene 250.00 Product

2 Aluminium

chloride


3 Sulphur 45.00 Methanol (recovered) 1212.50 Recycled

4 Toluene 1875.00 Distillation residue 25.00 To incinaration

5 methanol 1250.00 Solid

waste(carbon,hyflow,residue)

125.00 To TSDF

6 carbon 25.00 Process loss 57.50

7 hyflow 25.00 Aqueous Effluent (washing) 1500.00 To ETP

8 Water (washing) 1500.00 0.00

Total 5020.00 5020.00

47. 1,4-Dioxane-2,6-dione


Digol is oxidized with 60% Nitric acid to Digycolic acid, This was then cyclised to 1,4-

Dioxane-2,6-dione by refluxing in acetic anhydride.

Chemical Reaction:

OOHOH

HNO 3

O

O

OHOH

O

O

OO O

Acetic Anhydride

Digol

--CH 3COOH

1,4-Dioxane-2,6-dione

Mass Balance:

Sr.

No


Kgs Kgs

1 Digol 243.13 1,4-Dioxane-2,6-dione 250.00 Product

2 60% Nitric Acid 1146.80 Acetic acid (Recovered) 1651.38 Recycled

3 Acetic Anhydride 1662.85 Aqueous Effluent 2298.18 To ETP

4 Water 1146.75 Diisopropyl

ether(Recovered)

550.45 Recycled

5 Diisopropyl

ether


6 Carbon +Hyflow 45.88 Solid waste 50.45 To TSDF

Total 4818.80 4818.80

48. Diphenylditelluride


Take THf in reactor and add Magnesium turnings, heat reflux and add slowly chlorobanzene

maintaining reflux overnight, The fine tellurium powder is slurried in THF and cooled to 0 C

to this added phenyl magnesium chloride prepared from magnesium and chlorobenzene in

THF as above, stir overnight and pass oxygen gas slowly and water and extract the product

in dietyl ether, isolate product and recrystalise from ethyl acetate.

Chemical Reaction:

Cl

Mg

MgCl

THF THF Te

Te

Chlorobenzene Phenyl magnesium chloride Diphenyl telluride

Mass Balance:

Sr.

No


Kgs Kgs

1 Magnesium 5.80 Diphenylditelluride 100.00 Product

2 Tetrahydrofurane 440.00 Hexane (recovered) 580.00 Recycle

3 Chlorobenzene 27.20 Diethylether (recovered) 470.00 Recycle

4 Diethylether 500.00 THF (recovered) 400.00 Recycle

5 Hexane 600.00 Solidwaste 30.00 To TSDF

6 Tellurium 62.00 Aqueous Effluent (Effluent) 1244.00 To ETP

7 water 1200.00 Distillation residue 11.00

Total 2835.00 2835.00

49. Diphosphorus Tetraiodide


Iodine is dissolved in carbon tetrachloride and cooled to 0 C to this added phosphorus in

small portion and stirre for 24 hrs at rt, Again cooled to 0 C and precipitated product is

filtered and mother liquor is used for another cycle without any loss.

Chemical Reaction:

P + I2 P2I4

CS2

Phosphorus IodineDiphosphorus tetraiodide

Mass Balance:

Sr.

No

INPUT Qty

Kgs.

Output Qty.

Kgs

Remark

1 Iodine 94.12 Diphosphorus tetraiodide 100.00 Product

2 Phosphorus 11.76 Carbon disulphide 272.94 Recovered and

recycled

3 Carbon

disulphide

270.59 Hexane (recovered) 21.18 Recycled

4 hexane 23.53 Distillation residue 2.94 To incinaration

5 Water (washing ) 888.24 Aqueous effluent(from

washing )

888.24 To ETP


Total 1288.24 1288.24

50. 1,1-Dimethoxycyclohexane


The cyclohexanone, trimethyl orthoformate and catalytic amount of p-Toluenesulphonic

acid is refluxed for 24 hrs the generated methyl formate is distilled out and the product is

collected by vaccum distillation.

Chemical Reaction:

O

+ OCH3

H3CO

H3CO H

PTSA

OCH3H3CO

+ OCH3

H

O

CYCLOHEXANONE TRIMETHYL ORTHOFORMATE 1,1-DIMETHOXYCYCLOHEXANE METHYL FORMATE

Mass Balance:

Sr.

No


Kgs Kgs

1 Cyclohexanone 365.00 1,1-dimethoxy

cyclohexan

500.00 product

2 P-toluene sulphonic

acid

3.95 Distillation residue 32.80 To incinaration

3 Trimethyl

orthoformate

386.50 Trimethyl orthoformate 211.65 Recycle

4 Water (rector

washing)

2250.00 Distillation loss 11.00

5 0.00 Water (from washing ) 2250.00 To ETP

Total 3005.45 3005.45

51. alpha-amino-gamma-butyrolactone hydrobromide


L-methionine is treated with HBR gas In formic acid to form salt the formic acid is recycled

the water is added and refluxed for 24 hrs, the water is distilled along with dimethyl

sulphide out and the crude product obtained is recrystalised from n-Butanol.

Chemical Reaction:

OH

O

NH2

SCH3

HBr Formic acid

H2O n-ButanolO

O

NH2

+ CH3

SCH3

L-Methioninealpha amino gamma butyrolactone

+ H2O

Mass Balance:

Sr.

No


Kgs Kgs

1 l-methionine

225.00

alpha-amino-gamma-

butyrolactone.HBr 250.00

Product

2 HBr Gas 121.20 Dimethyl sulphide 83.93 By product

3 Formic acid 2257.50 Formic acid (recovered) 2242.50 Recycled


5 n-Butanol 907.50 n-Butanol(recovered) 897.28 Recycled

6 Process loss 10.00

7 Solid waste 5.00 To TSDF

Total 5783.70 5783.70

52. L-Methionine sulphone methylester


L-methionine is converted to corresponding methyl ester by reacting withThionyl Chloride

and Methanol, the product so obtained is further Oxidsed to L-Methionine sulphone

methylester by reacting with hydrogen Peroxide and acetic acid, The product is further

purified by recristalisation from ethyl acetate.

Chemical Reaction:

S

O

OHCH3

NH2

2. H2O2 CH3COOH

1. SOCl2 CH3OH

S

O

OCH3CH3

NH2

OO

L-methionineL-methioninesulphone methyl ester

- HCl -SO2

Mass Balance:

Sr.

No


Kgs Kgs

1 l-methionine 423.30 l-methionine sulphone

methyl ester

500.00 Product

2 Thionyl chloride 335.25 Methanol 4090.90 Recovered &

recycled

3 Methanol 4119.35 Acetic Acid 1647.75 Recovered &

recycled

4 Hydrogen

peroxide

204.55 Ethyl acetate 2215.90 Recovered &

recycled

5 Acetic acid 1704.55 Solid waste 62.50 To CSWD

6 Ethyl acetate 2272.75 Hydrogen chloride 102.25 To scrubber

7 Charcoal/hyflow 56.80 Sulphur dioxide 181.80 To scrubber

8 Water 2920.45 Aqueous Effluent 3193.20 To etp

9 Process loss 42.70 loss

Total 12037.00 12037.00

53. Methyl Gycolate


The glycolic acid is reacted with 2,2-dimethoxy propane in methanol using P-toluene

sulphonic acid as catalyst, the final product is purified by distillation.

Chemical Reaction:

OHOH

O

+CH3CH3

OCH3H3CO PTSA

MethanolOH

OCH3

O

Glycolic Acid Methyl Glycolate

Mass Balance:

Sr.

No


Kgs Kgs

1 Glycolic acid 250 Methyl glycoltae 250 Product

2 Methanol 2500.4 Methanol (Recovered ) 2661.6 Recycled

3 2,2-dimethoxy propane 171.1 Distillation residue 8.25 To Incineration

4 p-toluenesulphonic

acid


5 Water (washing) 1000 Aqueous effluent (from

washing)

1000 To ETP

Total 3926.45 3926.45

54. Methyl (R)-3-hydroxybutyrate


The methyl acetoacetate treated with enzymes in isopropyl alcohol using potassium

phosphate buffer at pH 6.5-7.5, the Iso propyl alcohol is recoved and recycled, the final

product si purified by distillation.

Chemical Reaction:

CH3 OCH3

OO

CH3 OCH3

OOHEnzyme

Isopropyl alcohol

Water

Methyl aceto acetateMethyl (R)-3-hydroxybutyrate

Mass Balance:

Sr.

No


Kgs Kgs

1 Methyl acetoacetate 2148 Methyl (R)-3-hydroxybutyrate 2000 Product

2 Isopropyl alcohol 21484 Isopropyl alcohol (recovered) 21298 Recycled

3 Water 21484 Methyl Tert Butylether

(recovered)

10556 Recycled

4 Enzyme 10 Water (distilled) 21964 recycled

5 Metyl tert butyl

ether

10738 Distillation residue 46 To incineration

Total 55864 55864

55. Sodium methyl sulfate


Dimethyl sulphate is treated with methanol and sodium bicarbonate under reflux, methanol

is recovered and the solid is slurried in acetone, filtered and dried in vacuum.

Chemical Reaction:

SH3CO OCH3

O

O

+ NaHCO3 SNaO OCH3

O

O

Methanol

Dimethyl sulphateSodium methyl sulfate

-CO2 -CH3OH

Mass Balance:

Sr.

No


Kgs Kgs

1 Dimethyl suplphate 198.44 Sodium methyl sulfate 200.00 Product

2 Methanol 1338.60 Methanol (Recovered) 1365.36 Recycled

3 Soduym carbonate 132.28 Carbon dioxide 69.28

4 Water (wasing ) 1000.00 Residue 15.76 To incineration

5 Process loss 18.92 To TSDF

6 Aqueous effluent (from

washing

1000.00 To ETP

Total 2669.32 2669.32

56. N,N-Dimethyl-p-phenylenediamine dihydrochloride


The para nitro chlorobenzene is trated with N,N-Diethyl amine in dimethyl formamaide

sodium hydroxide, sodium chloride is filtered the dimethyl amine is recovered by

distillation, the product is then reduced with raney nickel using hydrogen in methanol,

catalyst is filtered and hydrogen chloride gas is passed through methanol to get N,N-

dimethyl-p-phenylenediamine dihydrochloride.

Chemical Reaction:

NO2

Cl

DMF

NH

CH3

CH3

+O2N

NCH3

CH3

NH2

NCH3

CH3

HCl

Raney Ni

Methanol

HCl NaOH

H2 Gas

p-Nitrochlorobenzene Dimethylamine N,N-dimethyl-4-nitrobenzene N,N-dimethyl-p-phenylene diamine Hydrochloride

Mass Balance:

Sr.

No


kgs kgs

1 p-Nitro

Chlorobenzene

413.15 N,N-dimethylamine-p-

phenylenedimaine. HCl

500.00 Product

2 N,N-dimethyl amine 118.43 DimethylFormamide(recovered) 4078.98 recycle

3 Dimethyl formamide 4131.60 Methnaol (recovered) 3894.78 Recycle

4 Hydrogen 15.80 Raney Nickel (recovered) 73.68 Regenerati

on

5 Raney Nickel 73.68 Aqueous effluent 1988.70 To ETP

6 Methanol 3947.40 Sodium chloride(Dissolved salt) 153.95 To ETP

7 Hydrogen chloride

gas

193.43 Solid waste 31.58 To TSDF

8 Water 1815.80 Process Loss 13.95

9 Charcoal+Hyflow 26.33

Total 10735.60 10735.60

57. N-Aminorhodanine


Hydrazine hydrate is treated with carbon disulphide in methanol to get carbazide, the

carbazide is then reacted with mono chloro ethyl acetate in methanol to get N-

Aminorhodanine.

Chemical Reaction:

NH 2 N H 2 OH 2 + CS 2

NHNH 2

SH S

Methanol

-H 2S

ClCH 2COOEt

N

S

N H 2

S

O

-HCl

-C 2H 5OH

Hydrazine Hydrate

3-Aminorhodanine

-H 2 O

Mass Balance:

Sr.

No


Kgs Kgs

1 Hydrazine hydrate 33.78 N-Aminorhodanine 100.00 Product

2 Carbon disulphide 51.36 Methanol(Recovered) 344.60 Recycled

3 Methanol 337.84 Process loss 22.98

4 Chloroethyl acetate 82.44 NaCl 39.18 Dissolved salt to ETP

5 water 1537.84 Aqueous effluent 1563.52


7 Hyflow 6.76

8 NaOH 27.02

Total 2083.80 2083.80

58. N-Boc-3-pyrrolidinone


Benzyl amine is reacted with Ethyl acrylate in isopropyl alcohol, after completion of reaction

isopropyl alcohol is recovered to obtain oily residue (stge -1).

To residue methyl isobutyl ketone and sodium carbonate is added and refluxed, to the

refluxing solution ethylchloro acetate is added, refluxed overnight , cooled and added warm

water, organic layer is separated and solvent is recovered to the residue (stage -2).

Solution of sodium methoxide in methanol is added to stage 2 and refluxed over night, after

completion of reaction Conc hydrochloric acid and water is added and again refluxed

overnight with recovery of methanol. Neutralize reaction mass with dilute sodium hydroxide

and extract the product with Toluene, recover toluene and distille the pure product under

vacuum (stage -3)

The stage 3 is dissolved in methanol and catalyst Pd/C is added and hydrogenated with

hydrogen, after debenzylation the methanol is recovered and the 1.4-dioxane and sodium

hydroxide is added, cooled and Diboc solution in dioxane is added stirred till completion of

reaction dioxne is recovered and product is extracted in dichloromethane, solvent is

recovered and product is distilled under vacuum.

Chemical Reaction:

NH2

CH2

O CH3

O

NH OC2H5

OCl

O CH3

O

N

O

OC2H5

O

OC2H5

N O

+

1.Debenzylation Pd/C Methanol

2. DiBOC 1,4-dioxane Dichloromethane

N

BOC

O

Benzyl amine Ethyl chloro acrylate

ethyl chloroacetate

stage 1

stage 2

stage 3N-BOC-3-pyrrolidinone

Isopropyl alcohol

Na2CO3

NaOCH3 Toluene1.

2.HCl

-CO2 - Tert Butyl alcohol

H2

-Toluene( )

-CO2

-C2H5OH

-NaCl -CO2

Mass Balance:

Sr.

No


Kgs Kgs

1 Benzyl Amine 144.80 N-BOC-3-

pyrrolidinone

250.00 Product

2 Ethyl acrylate 135.13 Isopropyl alcohol 1000.00 Recycled

3 Isopropyl alcohol 1013.53 Toluene 1202.70 Recycled

4 Ethylchloroacetate 165.55 Methanol 1067.58 Recycled

5 Sodium carbonate 143.25 1,4-Dioxane 1000.00 Recycled

6 Sodium methoxide 72.98 Dichloromethane 1270.28 Recycled

7 Toluene 1081.08 Sodium chloride 159.45 Dissolved salt

top ETP

8 Hydrochloric acid 49.33 Carbondioxide gas 151.35

9 Pd/C 13.53 Tert butyl alcohol 100.00 By bypoduct

10 Hydrogen gas 2.70 Aqueous effluent 1621.63 To ETP

11 Methanol 1081.08 Pd/C 13.53 Regenerated

and recycled

12 DiBOC 294.60 Process loss 9.65

13 1,4-Dioxane 1013.53 0.00

14 Dichloromethane 1283.78 0.00

15 water 1351.35 0.00

Total 7846.15 7846.15

59. N-Boc-trans-4-hydroxy-L-proline methyl ester


The trans 4-hydroxy proline is dissolved in methanol and cooled to 0 c the Thionyl chloride is

added and stirred till completion of reaction, the methanol is recovered and

dichloromethane is added to the solid, Followed by addition of DiBOC and potassium

Carbonate, the reaction is stirred at Room Temperature till completion f reaction, the MDC

is recovered and product is recrystalised from Hexane.

Chemical Reaction:

NH

OH

O

OH

SOCl2

Methanol NH

OH

O

CH3

N

OH

O

OCH3BOC

DIBOC

MDC

K2CO3

Trans-4-Hydroxyproline Trans-4-Hydroxyprolinemethylester N-BOC Trans -4-hydroxyproline methylester

HCl

Mass Balance:

Sr.

No


Kgs Kgs

1 Trans-4-hydroxy

proline

145.56 N-BOC trans-4-hydroxy proline

methyl ester

250.00 product

2 Thionyl chloride 131.11 Methanol(recovered) 1422.22 recycled

3 Methanol 1455.56 MDC(recovered) 1300.00 recycled

4 DiBOC 92.22 Aqueous effluent (Effluent ) 1103.33 To ETP

5 MDC 1333.33 Solid waste 22.22 To TSDF

site

6 Potassium Carbonate 153.33 Hydrogen chloride gas 40.00 To scrubber

7 Water 1055.56 Sulpher dioxide gas 71.11 To scrubber

8 Carbon +hyflow 22.22 Potassium chloride(dissolved salt) 82.22 To ETP

0.00 Carbon dioxide 97.78

Total 4388.89 4388.89

60. 2-Nitrophenyl selenocyanate


The aqueous solution of potassium selenocyanate is added to the the diazotized solution of

para nitro aniline at room temperature and stirred overnight the precipitated product is

filtered and dried in vacuum oven.

Chemical Reaction:

NO2

NH2

NaNO2/HClNO2

N2Cl

+ KSeCN

NO2

SeCN

2-NITROANILINE

2-NITROPHENYLSELENOCYANATE

Mass Balance:

Sr.

No


Kgs Kgs

1 2-Nitroaniline 60.79 2-

nitrophenylselenocyanate

100.00 Product

2 Hydrochloric acid 52.86 Solid waste 13.22 To TSDF

3 Sodium nitirite 30.40 Aqueous effluent 1636.56 To ETP

4 Potassium

selenocyanate

63.44 Potassium chloide 32.60 To be sold

5 water 1607.93 Nitrogen gas 12.33

6 Carbon 6.61 Sodium chloride 25.74 Dissolved salt to ETP

7 Hyflow 6.61 Process loss 8.18

Total 1828.63 1828.63

61. Nonyl Maine


Deconoyl chloride is reacted with ammonium Hydroxide to get amide derivative which was

subjected to Hoffman degradation with Bromine, sodium methoxide and sodium hydroxide

in ethyl alcohol gives crude nonyl amine, The product is further purified by Vacuum

distillation.

Chemical Reaction:

CH3 O

Cl

NH4OH CH3 O

NH2

CH3 NH2

BROMINE , SODIUM ETHOXIDE,

H2O/ETHANOL

-CO2

-NaBr

H2O

NH4Cl

DECANOYL CHLORIDE

NONYL AMINE

Mass Balance:

Sr.

No


Kgs Kgs

1 Decanoyl chloride 281.48 Nonyl amine 200.00 product

2 Ammonium

hydroxide

48.88 Ethanol (recovered) 1244.48 recycled

3 Bromine 237.04 Aqueous effluent 2414.84 To ETP

4 Water 2340.76 Sodium bromide(dissolved

salt)

302.24 To ETP

5 Sodiummethoxide 299.28 carbondioxide 65.20

7 Ethanol 1111.16 Ammonium

chloride(dissolved salt)

80.00 Disolve to ETP

8 Distillation residue 11.84 To incinaration

Total 4318.60 4318.60

62. N-Boc-ethylenediamine


Ethylene diamnie is reacted with a one mole of Di-tert-butyl dicarbonate in tetrahydrofuran

at room temperature using potassium carbonate as base, the solvent is recovered and the

product is purified by solvent distillation.

Chemical Reaction:

NH2NH2 +

OOO

CH3

CH3

CH3

CH3

CH3CH3

O O

K2CO3ONH

NH2

O CH3

CH3

CH3

Ethylene diamine Di-tert-butyl dicarbonate N-BOC ethylenediamine

+ CO2

THF HCl

+ KCl

Mass Balance:

Sr.

No


Kgs Kgs

1 Ethylene diamine 41.67 N-BOC ethylene diamine 100.00 Product

2 Di Boc 151.39 THF (recovered) 409.72 Reused

3 Pottasium

carbonate

95.83 Aqueous effluent 499.72 To ETP

4 Tetrahydrofuran 416.67 Carbondioxide gas 30.56

5 Water 916.67 potassium chloride 82.22 To be sold

Total 1622.22 1622.22

63. Phenylselenylbromide


The diphenyl diselenide is slurried in Dichloromethane and cooled to 5 C, the bromine is

then added at 0-5 C and sitirred overnight, the Dichloromethane is recovered and product is

recrystalised from Pentane.

Chemical Reaction:

Se

Se

SeBrBr Br

MDC

Diphenyldislenide Phenylseleneyl Bromide

Mass Balance:

Sr.

No


Kgs Kgs

1 Diphenyldiselenide 165.00 Phenylselenyl bromide 250.00 Product

2 Dichloromethane 700.00 Pentane (recovered) 900.00 Recycled

3 Bromine 85.00 Dichloromethane(recovered) 650.00 Recycled

4 Pentane 1000.00 Process loss 150.00 To ETP

5 Water (washing) 2500.00 Aqueous effluent (from washing) 2500.00 To ETP

Total 4450.00 4450.00

64. Trimethylphenylammonium tribromide


A solution of N,N-dimethylaniline and toluene is prepared in reactor. The solution is stirred

and heated the dimethyl sulfate is added the product crystallize out. The product is filtered

and added to the hydrobromic acid diluted with water. Bromine is added to the stirred

solution to form orange-yellow precipitate immediately. The product, phenyltrimethyl

ammonium tribromide (PTT), is filtered, recrystallized from acetic acid.

Chemical Reaction:

NCH3CH3

+ (CH3)2SO4

N+

CH3CH3

CH3 CH3SO4 -

Toluene

N+

CH3CH3

CH3

BrH

Br2

Br3

Dimethylaniline Dimethylsulphate

Trimethylphenylammonium tribromide

126

159

CH3SO3H+H2O

Mass Balance:

Sr.

No


Kgs Kgs

1 N,N-

dimethylaniline

80.68 Trimethylphenylammonium

tribromide

250.00 Product

2 Toluene 800.00 Toluene (Recovered) 794.58 Recycled

3 dimethyl sulfate 84.00 Aqueous effluent 1121.60 To ETP

4 hydrobromic acid 166.68 Solid waste 13.83 To TSDF

5 Bromine 106.00 Process loss 7.33

6 Water 983.33 Acetic acid (recovered) 600.00 Recycled

7 Carbon 3.33 Methane sulfonic acid 65.00 To be sold

8 hyflow 3.33 0.00

9 Acetic acid (R/C) 625.00 0.00

Total 2852.33 2852.33

65. Phthalan


In a Rector water, sodium hydroxide and Benzyltriethylammonium chlorideis added and

heated, in portions o-dichloroxylene is added and stirred overnight and distill out the water,

now add toluene and extract the product, recover toluene and pure product is collected by

vacuum distillation.

Chemical Reaction:

Cl

Cl

+ NaOHO

Benzyltriethylammonium chloride

- NaCl - H2O

o-dichloroxylene phthalan

Mass Balance:

Sr.

No


Kgs Kgs

1 o-Dichlorobenzene 353.38 Phthalan 250.00 Product

2 Sodium hydroxide 192.31 Sodium chloride 283.96 Dissolved aslt to

ETP


4 Benzyltriethylammonium

chloride

3.62 Distillation residue 23.96 To Incinaration

5 0.00 Process loss 15.62

Total 2760.85 2760.85

66. Pottasium selenocyanate


The selenium powder is dissolved in Methanol and brought to reflux the potassium cyanide

is then added in portion from top, the refluxed overnight, methanol is recovered on ejector

vacuum and recrystalised product is collected and deried.

Chemical Reaction:

KCN + Se KSCN

PottasiumCyanide Selenium Pottasium Seleno Cyanate

Methanol

Mass Balance:

Sr.

No


Kgs Kgs

1 Methanol 1100.00 Pottasium selenocyanate 250.00 Product

2 Selenium 112.50 Methanol(Recovered) 1050.00 Recycled

3 Potassium

cyanide

137.50 Solid waste(carbon,hyflow) 30.00 To TSDF

4 Carbon 12.50 Process loss 45.00

5 hyflow 12.50 Aqueous effluent (washing ) 1250.00 To ETP

6 Water (washing ) 1250.00 0.00

Total 2625.00 2625.00

67. (+) S-2-Octanol


The 2-Octanone is treated with enzymes in isopropyl alcohol using potassium phosphate

buffer at pH 6.5-7.5, the Iso propyl alcohol is recovered and recycled, the final product Is

purified by distillation.

Chemical Reaction:

Enzyme

Isopropyl alcohol

Water

CH3

CH3

O

CH3

CH3

OH

2-Octanone(+)-2-Octanol

Mass Balance:

Sr.

No


Kgs Kgs

1 2- Octanol 538.00 (+)-S-2-Octanol 500.00 Product

2 Isopropyl alcohol 5378.50 Isopropyl alcohol (recovered) 5336.50 Recycled

3 Water 5378.50 Water (distilled) 5441.50 Recycled

4 Enzyme 5.00 Distillation residue 11.50 recycled

5 0.00 Process loss 10.50 To incineration

Total 11300.00 11300.00

68. S,S-2,5-Hexanediol


2,5-Hexanedione is subjected to enzymatic reduction with enzyme in IPA to get 2,5-

hexanediol.

Chemical Reaction:

CH3

O

O

CH3

isopropyl alcoholEnzyme

Buffer (pH-6.5) water

CH3

OH

OH

CH3

2,5-hexanedione S,S-2,5-Hexanediol

Mass Balance:

Sr.

No


Kgs Kgs

1 2,5-hexanedione 544.00 S,S-2,5-Hexanediol 500.00 Product

2 Isopropyl alcohol 5440.00 Isopropyl alcohol 5400.00 Recycled

3 Enzyme 12.00 Aqueous effluent 3100.00 To ETP

4 Water 1500.00 Solid waste 140.00 To csws

5 Glucose 160.00 Distillation residue 16.00 To incinaration

6 Buffer solution (pH-6.5) 1500.00 0.00

Total 9156.00 9156.00

69. Tetrahydro-4H-thiopyran-4-one


N-methylpiperidone in ether was reacted with methyl iodide to form corresponding iodide

salt, the salt was filtered off and dissolved in water followed by addition of sodium sulphide

and then refluxed overnight. The organic layer is then separated, solvent is recovered and

crude product is recrystalised from hexane.

Chemical Reaction:

N

O

CH3

CH3I

Ether

N+

O

CH3CH3

I-

S

O

Na2S H2O

4-Methylpiperidone Tetrahydro-4H-thiopyran-4-one

--(CH3)NH -NaI

Mass Balance:

Sr.

No


Kgs Kgs

1 N-methylpiperidone 269.05 Tetrahydro-4H-thiopyran-4-

one 250.00

Product

2 Methyl iodide 335.70 Ether(recovered) 1130.95 recycled

3 Ether 1190.50 Dimethyl amine .HCl 192.85 By product

4 Sodium sulphide 185.70 Hexane (recovered) 1404.75 recycled

5 Water 2904.75 Sodium iodide 357.15 To be sold

6 Hexane 1428.55 Aqueous effluent 2940.50 To ETP


8 hyflow 23.80 Process loss 38.10

Total 6361.85 6361.85

70. trans-2-cyclopropanecarboxylic Acid


Cinnnamic acid is reacted with Thionyl chloride to give cinnnamyl chloride, which is treated,

N,N- dimethyl aniline and tertbutylalcohol, to give tertbutyl cinnamate which is further

reacted with trimethyl sulfoxonium iodide and sodium hydride to give ester, the ester on

hydrolysis gives trans-2-cyclopropanecarboxylic Acid, the product is filtered, and washed

with methanol and recrystalised from ethyl acetate.

Chemical Reaction:

OH

O

CH3

CH3

CH3OHCl

O

N

CH3

CH3

NH2

O

CH3

CH3

CH3

Na H TMSI

CH3 CH3

CH3

O

OH

O H2SO4

Dichloromethane

136

SOCl2

Cinnamic acid

trans-2-phenylcyclopropanecarboxylic acid

Mass Balance:

Sr.

No


Kgs Kgs

1 Cinnmic acid 282.44 trans-2-cyclopropanecarboxylic

Acid

250.00 Product

2 Thionyl chloride 225.19 Dichloromethane (recovered) 2786.26 Recycled

3 Tert butyl alcohol 141.22 Ether(recovered) 2767.18 Recycled

4 N,N-dimethyl aniline 230.92 Toluene(recovered) 2824.43 Recycled

5 Sodium hydride 45.80 N,N-dimethylanilne

(regenerated)

219.47 Recycled

6 Trimethyl sulfoxonium

iodide

419.85 Sodium iodide ( salt ) 286.26 To be sold

7 Sulfuric acid 187.02 Sodium chloride (dissolved salt 111.64 To ETP

8 Dichloromethane 2824.43 Hydrogen chloride Gas 69.66 To

Scrubber

9 Ether 2862.60 Sulfurdioxide gas 122.14 To

Scrubber


11 Sodium sulphate 38.17 Solid waste 47.71 To TSDF

12 water 3816.79 Process loss 110.69

14 Sodium hydrooxide 76.34

15 Hyflow +carbon 47.71

Total 14061.07 14061.07

71. Triisopropanolamine cyclic borate


Triisopropanolamine is reacted with Boric acid in Tolune at reflux, the water formed during

reaction is contineousaly distilled, After completion of reaction Pet ether is added and the

crystalised product is filtered and dried in vacuum.

Chemical Reaction:

N

O

B

O

CH3

CH3

OCH3

N

OH

CH3

OH

CH3

OH

CH3

+B

OH

OH OHToluene Petether

-H2O

Trisisopropanol amine

Boric AcidTriisopropanolamine cyclic borate

Mass Balance:

Sr.

No


Kgs Kgs

1 Triisopropanolamine 254.00 Triisopropanolamine cyclic

borate

250.00 Product

2 Boric acid 81.10 Toluene (Recovered) 924.20 Recycled

3 Toluene 930.85 Pet ether (recovered) 924.20 Recycled

4 Pet ether 930.85 Aqueous effluent 71.80 To ETP


6 Solid waste 13.30 To TSDF

7 Aqueous effluent (from

washing)

1250.00

Total 3446.80 3446.80

72. Tropinone


Hydrochloric acid is added to the 2,5-dimethoxy furane and left overnight to form

succinaldehyde solution, to this were added methyl amine hydrochloride, acetone

dicarboxylic acid, acetic acid and sodium Hydroxide, sittred overnight, next day the pH is

made alkaline with sodium carbonate and the product is extracted with Dichloro methane,

solvent is recovered and product is purified by distillation.

Chemical Reaction:

OH3CO OCH3 HCl

HH

O

O

COOH

COOH

O+ CH3NH2.HCl+

--CO2 CH3COOH

NaOH

NO CH3

-NaCl

-CH3COONa

2,5-Dimethoxy furan succinaldehydeAcetone dicarboxylic acid

Tropinone

Mass Balance:

Sr.

No


Kgs Kgs

1 2,5-dimethoxy furane 255.80 Tropinone 250.00 Product

2 Hydrochloric acid 234.50 Dichloromethane

(Recovered) 1531.00

Recycled

3 Methyl amine HCl 130.80 Methanol (Recovered) 124.05 Recycled

4 Acetone dicarboxylic acid 282.95 Carbondioxide gas 170.55

5 Acetic acid 116.30 Sodium chloride 114.35 To ETP

6 Sodium hydroxide, 77.50 Sodium acetate 158.90 To be sold

7 Dichloromethane 1550.40 Aqueous effluent 2736.40

8 Water 2469.00 Distillation residue 32.00

Total 5117.25 5117.25

73. 2-amino-5-chlorbenzene sulphonicacid


p-Chloro aniline is subjected to sulfonation with concentrated sulfuric acid at 80 c to get the

2-amino-5-chlorobenzene sulfonic acid.

Chemical Reaction:

NH2

Cl

+ H2S2O7

NH2

Cl

SO3H

p-CHLOROANILINE 2-AMINO-5-CHLOROBENZENESULPHONIC ACID

Ca(OH)2

+ CaSO4 + H2O

Mass Balance:

Sr.

No


Kgs Kgs

1 P-CHLOROANILINE 171.62 2-amino-5-

chlorobenzenesulphonic acid

250.00 Product

2 Sulfuric acid 240.54 Calcium sulphate 183.78 To TSDF


4 Calcium hydroxide 104.05 Methanol (recovered) 1000.00 Recycled

5 Methanol 1013.51

Total 2881.08 2881.08

74. 4-methyl-2-pipecolic acid Hydrochloride


4-methyl piperdine is reacted with methyl formate, which is subjected to electrolysis, it forms the

corresponding acid which was then isolated and purified by recrystalisation from Acetone.

Chemical Reaction:

NH

CH3

H

OCH3

O

+-- H2O N

H3CO O

CH3 Electrochemistry

NH

CH3

COOH

4-methylpipecol4-methyl-2-pipecolic acid

methyl formate

Methanol

Platinum electrode

Mass Balance:

Sr.

No


Kgs Kgs

1 2-methylpipecol

138.27

4-Methylpipecolic acid

.HCl 250.00

Product

2 Methylformate 83.80 Methanol (Recovered) 1229.05 REcycled

3 Methanol 1256.98 Acetone (recovered) 1089.39 recycled

4 Water

1117.32

Aqueous effluent

(Effluent ) 1117.32

To ETP

5 Acetone 1117.32 Solid waste 34.92 To TSDF

6 Charcoal +Hyflow 34.92 Process loss 27.93

Total 3748.60 3748.60

75. N-Methylhydrazinecarboximidamide hydroiodide


Thiosemicarbazide is reacted with methyl iodide in methanol to give intermediate salt this

was the reacted with Methanolic Methylamine solution gives N-

Methylhydrazinecarboximidamide hydroiodide, the crude product is purified from

Isopropanol.

Chemical Reaction:

S

NH

NH2

NH2CH3I

S

NH

NH2

+

NH2

CH3I-

CH3NH2 NH

NH

NH2

+

NH2

CH3I-CH3OH CH3OH

Thiosemicarbazide N-Methylhydrazinecarboximidamide hydroiodide

+ CH3SH+

Mass Balance:

Sr.

No.


Kgs Kgs

1 Thiosemicarbazide 105.32 N-Methylhydrazinecarboximidamide

hydroiodide

250.00 Product

2 Methyl Iodide 163.19 Methanol (Recovered ) 1030.09 Recycled

3 Methyl amine 35.88 Isopropyl alcohol (Recovered ) 856.48 Recycled

4 Methanol 1053.24 Methyl amine 55.56 Recycle

5 Isopropyl alcohol 868.06 Process loss 27.78

6 Hyflow+ Carbon 28.94 Solid waste 23.15 To TSDF

7 Water (Washing) 1868.06 Aqueous effluent (washing ) 1879.63 To ETP

Total 4122.69 4122.69

76. Tetraphenylcyclopentadienone


Benzil and dibenzyl ketone are mixed and refluxed in toluene in presence of p-Toluene

sulfonic acid as catalyst to get Tetraphenylcyclopentadienone, the product is crystalised

from Ethyl alcohol.

Chemical Reaction:

O

Ph Ph

O

+ Ph Ph

O

O

Ph

Ph Ph

Ph

Benzil Dibenzylketone Tetraphenylcyclopentadienone

Toluene , PTSA

+ 2 H2O

Mass Balance:

Sr.

No


Kgs Kgs

1 Benzyl 140.00 Tetraphenylcyclopentadienone 250.00 Product

2 Dibenzyl Ketone 140.00 Toluene (Recovered) 920.00 Recycled

3 Toluene 933.33 Ethylalcohol ( Recovered) 520.00 Recycled

4 Ethyl alcohol 533.33 Aqueous effluent 700.00 To ETP


6 0.00 Solid waste 10.00 To TSDF

Total 2413.33 2413.33

77. 4,6-Dimethylpyrimidine


Formamide is reacted with Acetylacetone in refluxing Toluene using p-Toluenesulphonic

acid. The product formed is recrystalised Ethylacetate.

Chemical Reaction:

H NH2

O O

CH3 CH3

O

N N

CH3 CH3

CO 3H2O2 + + +PTSA

Formamide Acetylacetone 4,6-Dimethylpyrimidine

Mass Balance:

Sr.

No


Kgs Kgs

1 Formamide 208.33 4,6-Dimethylpyrimidine 250.00 Product

2 Acetylacetone 231.48 Aqueous effluent

(washing)

2671.30 To ETP

3 P-Toluenesulfonic acid 2.31 Ethyl Acetate

(recovered)

1712.96 recycled

4 Ethyl Acetate 1736.11 Carbon Monoxide 64.81

5 Water (washing) 2546.30 Solid waste 57.87 To TSDF

6 Carbon +Hyflow 57.87 Process loss 25.46

Total 4782.41 4782.41

78. 2-chloro-3,4~dimethoxybenzaldehyde


3-hydroxy-4-methoxybenzaldehyde is chlorinated with chlorine in DMF, the intermediate so

obtained is reacted with Dimethyl sulfate in aq sodium hydroxide to get 2-chlro-3,4-

dimethoxybenzaldehyde and recrystalised from hexane.

Chemical Reaction:

CHO

OH

OCH3

+ Cl Cl

Dimethyl Formamide

CHO

OH

OCH3

Cl(CH3)2SO4 NaOH

CHO

OCH3

OCH3

Cl

-- Na2SO4--HCl

3-Hydroxy-4-methoxybenzaldehyde 2-chloro-3,4-methoxybenzaldehyde

Mass Balance:

Sr.

No


Kgs Kgs

1 3-hydroxy-4-

methoxybenzaldehyde

190.00 2-chlro-3,4-dimethoxy

benzaldehyde

223.75 Product

2 Dimethyl formamide 1500.00 Hexane (Recovered) 937.50 Recycled

3 Dimethyl sulphate 157.50 Sodium sulphate (dissolved

salt )

148.75 To ETP

4 Sodium hydroxide 50.00 Aqueous effluent 1462.50 To ETP

5 Hexane 1000.00 Solid waste 31.25 To TSDF

6 Water 1000.00 Dimethyl formamide

(Recovered)

1125.00 Recycled

7 Charcoal +Hyflow 31.25

Total 3928.75 3928.75

79. N,N-dimethyl Sulfomoyl chloride


Sulfuryl chloride is reacted with N,N-dimethylamine Hydrochloride under refluxed, the

excess of sulfury chloride is neutralized and product is extracted with ether, the ether is

recovered product is purified by distillation.

Mass Balance:

Sr.

No


Kgs Kgs

1 Dimethylamine HCl 153.41 N,N-dimethyl Sulfomoyl chloride 250.00 Product

2 Sulfuryl chloride 253.79 Sodium chloride (dissolved salt) 219.70 To ETP

3 Sodium carbonate 198.86 Carbondioxide 83.33

4 Water washing 1420.45 Aqueous effluent (from

washing)

1454.55 To ETP

5 0.00 Distillation residue 18.94 To

Incinaration

Total 2026.52 2026.52

80. 3-Acetamido-6-methoxy benzene sulfonyl chloride


4-methoxy acetanilide is reacted with chlorosulphonic acid at 50-60 C to get 3-Acetamido-6-

methoxy benzene sulfonyl chloride, the crude product is then recrystalised from acetone.

Chemical Reaction:

OCH3

NH

CH3

O

+ ClSO3H

OCH3

NH

CH3

O

S

O

O

Cl

4-methoxyacetanilide 3-Acetamido-6-methoxy benzene sulfonyl chloride

+ OH2

Mass Balance:

Sr.

No


Kgs Kgs

1 4-methoxy acetanilide 195.50

3-Acetamido-6-methoxy benzene

sulfonyl chloride 250.00 Product

2 Chlorosulphonic acid 137.44 Aqueous effluent 2251.18 To ETP

3 Acetone 1421.80 Acetone (Recovered) 1386.26 Recycled

4 Water(ice) 2132.70 0.00

Total 3887.44 3887.44

ANNEXURE - IV

WATER CONSUMPTION AND WASTEWATER GENERATION

Sr. No.

Purpose Water Consumption Waste Water Generation

KL / Day KL / Day

1. Process 22.5 22.0

2. Boiler 20.0 1.0

3 Cooling 20.0 1.0

3. Washing 2.0 2.0

4. Scrubber 2.0 2.0

Total 66.5 28.0*

5. Other (Gardening) 4.5 Nil

5. Domestic 2.0 1.8

Grand Total 73 29.8

NOTE:

* Out of process effluent @ 28 KL/Day, about 25 KL/Day effluent will be dilute stream and

remaining 3 KL/Day will be concentrated stream.

Water Balance Diagram:

Fresh Water-

73 KL/Day

Domestic-

2.00 KL/Day

Boiler-

20.0 KL/Day

Cooling-

20.0 KL/Day

Scrubber-

2.0 KL/Day

Process-

22.5 KL/Day

Domestic

Wastewater-

1.8 KL/Day

1.0 KL/Day 1.0 KL/Day 2.0 KL/Day

22.0 KL/Day

Septic

tank/Soak Pit 25.0 KL/Day

Treated Effluent will

be sent to CETP

Washing-

2.0 KL/Day

2.0 KL/Day 19.0 KL/Day

(Dilute stream)

3.0 KL/Day

(concentrated stream)

Effluent will be sent to

Common Incineration

Facility

ETP

Gardening

4.5 KL/Day

ANNEXURE - V

EFFLUENT TREATMENT PLANT

BRIEF DESCRIPTION OF ETP

M/s. Ecolec Bioscience Pvt. Ltd. shall have an Effluent treatment plant consisting of primary

and secondary treatment units. The effluent confirming to inlet standards of GIDC drain. The

details of ETP are as follows.

For LOW COD AND TDS Stream I (25 KLD)

First all non-toxic and biodegradable streams of wastewater shall be collected in

Equalization cum Neutralization Tank (ENT). Here caustic is added from Caustic Dosing Tank

(CDT) by gravity to maintain neutral pH of wastewater. Mixer is provided in ENT to keep all

suspended solids in suspension and to provide proper mixing.

Then after, neutralized wastewater shall go to Flash Mixer (FM) by gravity. Alum and

Polyelectrolyte shall be dosed from Alum Dosing Tank (ADT) and Polyelectrolyte Dosing Tank

(PEDT) respectively by gravity into FM to carry out coagulation by using a Flash Mixer.

Then after, coagulated wastewater shall be settled in Primary Tube Settler (PTS).Clear

supernatant from PTS shall be passed in Aeration Tank (AT). In AT biodegradation of organic

matter of the wastewater shall be carried out by bacteria (suspended growth) and for that

oxygen shall be supplied by 2 nos. of air blowers (B-01) through diffusers. Air blowers also

keep MLSS in suspension. Nutrients will be added from Nutrient Dosing Tanks (NDTs) to

Aeration Tank for growth of Bacteria.

Then after, waste water shall go to Secondary Settling Tank (SST) from AT. Here, the

suspended solids shall be settled. Sludge shall be removed from bottom of SST and pumped

to AT to maintain MLSS and excess activated sludge shall be sent to Sludge Sump (SS). Clear

supernatant from SST shall be collected in Treated Effluent Sump (TES) before sent to GIDC

drain.

Sludge settled in PTS and excess sludge from SST shall be collected in Sludge Sump. Then

sludge shall be pumped to Filter Press where, dewatering shall be carried out before storage

in HWSA and ultimate disposal to TSDF. Leachate from FP shall be sent back to ENT for

further treatment.

High COD and TDS concentrated Stream II (3 KLD) will be sent to Common Incineration

facility.

DESIGN DETAIL OF ETP

SIZE OF TANKS

S.N. Name of unit Size (m x m x m) No. MOC/

Remark

Steam I -Low COD and TDS Stream (25 KLD )

2 Equalization cum

Neutra-lization Tank

(ENT)

3.2 x 3.2 x (2.5LD+0.5 FB) 1 RCC M25+A/A

Bk. Lining

4 Flash Mixer (FM) 0.8 x 0.8 x (1.5 LD +0.5

FB)

1 RCC M25

5 Primary Tube Settler (PTS) 2.0 x 1.2 x (2.0 LD + 0.75

HB+ 0.5 FB)

1 RCC M25

6 Aeration Tank (AT) 7.0 x 5.2x (3.5 LD +0.5FB) 1 RCC M25

7 Secondary Settling

Tank(SST)

2.0 x 1.2 x (2.0 LD + 0.75

HB+ 0.5 FB)

1 RCC M25

10 Sludge Sump (SS) 1.5 x 1.5 x (2.5 LD + 0.5) 1 RCC M25

11 Filter Press (FP) 8 M3 / day 1 PP

12 Treated Effluent Sump(TES) 3.2 x 3.2 x (2.5LD+0.5 FB) 1 RCC M25

RCC M25 = REINFORCED CEMENT CONCRETE (M 25 GRADE)

PCC = PLAIN CEMENT CONCREAT

SS = STAINLESS STEEL

PP = POPYPROPELINE

FLOW DIAGRAM:

ANNEXURE-VI

DETAILS OF HAZARDOUS WASTE GENERATION & DISPOSAL

CAT.

NO.

HAZARDOUS

WASTE QUANTITY MODE OF

STORAGE METHOD OF DISPOSAL

5.1 Used Oil

200 Liters/Year

Collected in barrels

& stored in

hazardous waste

storage area

Will be Sent to GPCB

approved re refiners

33.3 Discarded

barrels/

containers/

liners

5 MT/Year

i. e.

250 Nos./Month

Stored in

hazardous waste

storage area

Will be Sent back to

supplier / to GPCB

approved recycler

34.3 ETP Sludge 15 MT/Month Collected in plastic

/ HDPE bags &

stored in

hazardous waste

storage area

Will be Sent to TSDF site

for secured land filling

28.1 Distillation

Residue

5 MT/Month Collection in Barrel

& stored in

hazardous waste

storage area

Will be Sent for

Incineration at common

incineration facility.

28.1 Process Waste 18 MT/Month Collected in plastic

/ HDPE bags &

stored in

hazardous waste

storage area

Will be Sent to TSDF site

for secured land filling

D2 Dilute

Hydro Chloric

Acid

13 MT/Month Collected in plastic

/ HDPE bags &

stored in

hazardous waste

storage area

Will be Sent to end

users.

ANNEXURE-VII

DETAILS OF AIR POLLUTION CONTROL SYSTEM

FLUE GAS EMISSION

Nos.

of

Stack

Stack Attached to Stack Height

& Diameter

Type & Consumption of fuel Air Pollution Control

System

1 Steam Boiler

Capacity : 800 Kg/hr

Height :

20 Meters

Dia: 8 inch

Natural gas@

36 scm/hr

Natural

gas@

72 scm/hr

--

2 Thermic Fluid Heater

(4,00,000 cal./Hour.)

Height :

20 Meters

Dia: 8 inch

Natural gas@

36 scm/hr

--

2 D. G. Set - Stand By

Capacity : 125 KVA

Height :

10 Meters

Dia: 5 inch

LDO

20 Liters/Hr

As LDO is used as a fuel,

no air pollution control

system is required.

PROCESS GAS EMISSION

Nos. of

Stack Vent Attached to

Vent Height &

Diameter Pollutants

Air Pollution

Control System

1 Sulphonation

Vessel

Height : 13 Meters

Dia: 5 inch

SO2 40 mg/Nm3 Alkali Scrubber

2 Chlorination Vessel Height : 13 Meters

Dia 5 inch

HCl

Cl2

20 mg/Nm3

9 mg/Nm3

Water Scrubber

3 Amination Vessel Height : 13 Meters

Dia 5 inch

NH3 175 mg/Nm3 Water Scrubber

ANNEXURE-VIII

DETAILS OF HAZARDOUS CHEMICALS STORAGE & HANDLING

Sr.

No.

Raw Materials Storage

Capacity

(MT)

Type of

Storage &

MOC

No. of

Vessel

Vessel Capacity

(MT)

Type of

Hazard

1 Methanol 2.00 Drums 20 200 Kg Flammable

2 Ethanol 1.00 Drums 10 200 Kg Flammable

3 Isopropanol 2.00 Drums 20 200 Kg Flammable

4 Tetrahydrofurane 1.00 Drums 10 200 Kg Flammable

5 Ethyl Acetate 1.00 Drums 10 200 Kg Flammable

6 Ether 1.00 Drums 10 200 Kg Flammable

7 Dichloro Methane 2.00 Drums 20 200 Kg Flammable

8 Bromine 0.50 Bottles 150

3 Kg Glass

Bottle Toxic

9 Chlorine 0.50 Cylinder 2 250 Kg Cylinder Toxic

10 Ammonia 0.50 Cylinder 4 250 Kg Cylinder Toxic

11 Toluene 1.00 Drums 10 200 Kg Flammable

12 Acetone 1.00 Drums 10 200 Kg Flammable

13 Carbon Disulphide 0.50 Drums 2 200 Kg Flammable

14 Hexane 0.50 Drums 3 200 Kg Flammable

15 Hydrochloric Acid 0.50 Drums 2 250 Kg Corrosive

16 Sulphuric Acid 1.00 Carboys 15 65 Kg Corrosive

17 Acetic Acid 0.50 Carboys 15 35 Kg Corrosive

18 Acetic Anhydride 0.50 Carboys 15 35 Kg Corrosive

19 Aluminiumchloride 0.50 Bags 20 25 Kg Corrosive

20 Nitric Acid 0.25 Carboys 5 50 Kg Corrosive

21 Thionyl Chloride 0.50 Drums 2 250 Kg Corrosive

22 Hydrogen 0.50 Cylinder 10 50 Kg Flammable

23 Sodium Hydroxide 0.50 Bags 10 50 Kg Corrosive

24 Chloroform 0.50 Drums 2 250 Kg Flammable

25 Sodium Hydride 0.25 Ms Drum 1 250 Kg Flammable

26

Phosphorus Oxy

Chloride

0.25

Carboys 5 50 Kg Corrosive

ANNEXURE – IX

SOCIO - ECONOMIC IMPACTS

1) Employment Opportunities

The manpower requirement for the proposed project is being expected to generate some

permanent jobs and secondary jobs for the operation and maintenance of plant. This will

increase direct / indirect employment opportunities and ancillary business development to

some extent for the local population.

This phase is expected to create a beneficial impact on the local socio-economic

environment.

2) Industries

Required raw materials and skilled and unskilled laborers will be utilized maximum from the

local area. The increasing industrial activity will boost the commercial and economical status

of the locality, to some extent.

3) Public Health

The company regularly examines, inspects and tests its emission from sources to make sure

that the emission is below the permissible limit. Hence, there will not be any significant

change in the status of sanitation and the community health of the area, as sufficient

measures have been taken and proposed under the EMP.

4) Transportation and Communication

Since the existing factory is having proper linkage for the transport and communication, the

development of this project will not cause any additional impact. In brief, as a result of the

expansion there will be no adverse impact on sanitation, communication and community

health, as sufficient measures have been proposed to be taken under the EMP. The

proposed expansion is not expected to make any significant change in the existing status of

the socio - economic environment of this region.

ANNEXURE-X

______________________________________________________________________

PROPOSED TERMS OF REFERENCE FOR EIA STUDIES

1. Project Description

• Justification of project.

• Promoters and their back ground

• Project site location along with site map of 5 km area and site details providing various

industries, surface water bodies, forests etc.

• Project cost

• Project location and Plant layout.

• Water source and utilization including proposed water balance.

• Product spectrum (proposed products along with production capacity) and process

• List of hazardous chemicals.

• Mass balance of each product

• Storage and Transportation of raw materials and products.

2. Description of the Environment and Baseline Data Collection

• Micrometeorological data for wind speed, direction, temperature, humidity and rainfall

in 5 km area.

• Existing environmental status Vis a Vis air, water, noise, soil in 5 km area from the project

site. For SPM, RSPM, SO2, NOx.

• Ground water quality at 5 locations within 5 km.

• Complete water balance

3. Socio Economic Data

• Existing socio-economic status, land use pattern and infrastructure facilities available in

the study area were surveyed.

4. Impacts Identification And Mitigatory Measures

• Identification of impacting activities from the proposed project during construction and

operational phase.

• Impact on air and mitigation measures including green belt

• Impact on water environment and mitigation measures

• Soil pollution source and mitigation measures

• Noise generation and control.

• Solid waste quantification and disposal.

5. Environmental Management Plan

• Details of pollution control measures

• Environment management team

• Proposed schedule for environmental monitoring including post project

6. Risk Assessment

• Objectives and methodology of risk assessment

• Details on storage facilities

• Process safety, transportation, fire fighting systems, safety features and emergency

capabilities to be adopted.

• Identification of hazards

• Consequence analysis through occurrence & evaluation of incidents

• Disaster Management Plan.

7. Information for Control of Fugitive Emissions

8. Post Project Monitoring Plan for Air, Water, Soil and Noise.

9. Information on Rain Water Harvesting

10. Green Belt Development plan

list of annexures sr. no. name of annexure of annexures sr. no. name of annexure i list of products...

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