liver slides
TRANSCRIPT
Liver
Additional images from: http://www.bu.edu/histology/
and http://w3.ouhsc.edu/histology
Portal Triad (+lymph!)
Portal Triad (+ lymph!)
Portal Triad
Portal Triad (+lymph!)
Portal Triad (+lymph!)
Cords and Sinuses
Central Vein
The Lobules3 modes of architecture
• Classic Lobule – a hexagon with a central vein in the middle and portal triad (hepatic artery, portal vein, bile duct) at boundary points.
• Portal Lobule – connects 3 adjacent central veins into a triangle; it follows bile drainage
• Liver acinus – diamond shaped and bordered by 2 central veins and portal triads.
Classic Lobule
Classic Lobule
Portal Lobule
Liver acinus
Three Lobules
1)CLASSIC 2)PORTAL 3) LIVERACINUS
Shape: Polygon Triangle EllipseCentral Vein: Central 3 tips 2 tips
Lymph
• Endothelium of Sinusoids is fenestrated• Space of Disse = place of exchange of
materials between blood and hepatocyte
Space of Disse
Space of Disse
Bile
-Made by hepatocytes
-Drained into Bile ducts
-Moves in opposite direction from blood to portal triad
-Nasty stuff – Caniculi are bounded by tight junctions
Bile Canaliculus
Bile Canaliculus
Bile Canaliculus
Bile Canaliculus:
• holds bile
• btwn hepatocytes
• tight junctions
• communicates with bile duct
• flows in opposite direction of blood
Space of Disse:
• holds lymph
• communicates with sinusoids via fenstrations and with Space of Moll and lymphatics
Bile Canaliculus:
• holds bile
• btwn hepatocytes
• bounded by tight junctions
• communicates with bile duct
• flows in the opposite direction to blood
Space of Disse:
• holds lymph
• communicates with sinusoids via fenstrations and with Space of Moll and lymphatics
• flows in the direction of blood
What is at the pointer?
Is it carrying blood/bile to/from hepatocytes?
Portal Vein
What is at the pointer?
Is it carrying blood/bile to/from hepatocytes?
Bile duct
It is carrying bile from the hepatocytes?
Other elements
Kupffer Cell
Kupffer Cell
Practice
Practice your Liver - Silver
Practice your Liver - Silver
Liver EM
Liver EM