3DS.

COM/

BIOV

IA

Das

sault

Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Simulating Disease States with the Living Heart Human Model

Dassault Systmes

Twitter: @BaillargeonBP

Enric Estruch Traveria Jiang Yao

Tom Battisti Karl DSouza

Brian P. Baillargeon

2

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

The Living Heart Project

Mission: Advance the development of safe & effective cardiovascular products and treatments by uniting engineering, scientific, & biomedical experts to deliver validated models and translate simulation technology into improved patient care

3DS.

COM/

BIOV

IA

Das

sault

Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Modeling a Living Heart Multiphysics

Multiscale Tissue Cellular Protein Molecular

Mechanical

Fluid

Electrical

4

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Building the Living Heart Model (LHM)

( )[ ] ( )[ ]{ } ( )[ ]=

++=sfi

fsfsfs

fsii

i

idev Ibb

aIb

baIb

ba

,

28

241 1exp2

11exp2

3exp2

New Tissue Models

Detailed Fiber Orientations

Coupled Multi-physics

Geometry from Scan Data

Valves, Fluid Pressure,

5

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Electrical Results

6

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Mechanical Results

Mitral Valve

Motion with the Ventricles Removed

Heart Disease - diagnosis & treatments

Bio-treatments

Medical Image Enhancement

Data Analytics

3DPrinting Medical Devices

8

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

LHM Initial Hemodynamics

Initial model tuning efforts were performed using the 3D model

However, despite efforts, the hemodynamic response of the LHM still exhibited some non-physiological behavior

We needed a new approach to correct this Focusing on the hemodynamics also could

be leveraged as these conditions are altered for disease states Downward slope

9

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

The Challenge Simulating Disease

How can we efficiently adapt the model to simulate a more accurate healthy state and disease states? 3D modeling was too expensive There are many model parameters Many cardiac cycles (10+) may be required to achieve a

steady-state response for diseased states

10

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Hemodynamic Workflow For Alternate States

Design-of-Experiments Improved Shape of LV chosen from DOE database

LPM taught from 3D Model

Final LV PV Loop (5 Cardic Cycles)

LPM Model Run Iteratively

Original profile

11

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

LHM DOE Database SQL database including 296 entries varying

Material parameters (10 parameters, a, b, t0, m, b etc)

Viscous resistance for fluid exchanges (7 parameters)

Elasticity for compliances (3 parameters)

Extracted key model measurements

Systolic and diastolic blood pressure and volume for all 7 compartments

Cardiac output, stoke volume/work, ejection fraction

Systemic and pulmonary vascular resistances

Very detailed queries can be made following the SQL language

e.g. Give me the 10 jobs with the highest ejection fraction and tell me the material parameters for the LV

Show me the PV loop of the last beat of all runs that have a minimum pressure in LA of 5mmHg

Data structure Hemodynamic Material Pressure-Volume

Hemodynamic Data for each run

X-Y Plot

12

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Database Verification Disease States (1/2)

Left Ventricle Right Ventricle

Impact of changing the afterload (e.g. Hypertension)

13

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Database Verification Disease States (2/2)

Impact on Left Ventricle with Varying Valve Resistance (e.g. Mitral Valve Stenosis)

Impact on Left Ventricle due to Loss (e.g. lack of oxygen or excess CO2) or Increase (e.g. due to a drug) in Contractility

15

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Improved Hemodynamic Results for the LHM

LV PV Loops (5 Cardic Cycles)

Pressure vs Time for LV (red), LA (blue) and Arterial System (black)

16

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Summary

The LHM is a 3D, high fidelity multi-physics simulator An efficient hemodynamics-based methodology was developed to rapidly bring

the LHM to alternate cardiac states This methodology will be utilized to tune the model for other specific diseases

18

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5 The Living Heart Project

www.3ds.com/heart

19

3DS.

COM

Da

ssau

lt Sys

tmes

| Con

fiden

tial In

forma

tion

| 5/24

/2017

| ref.

: 3DS

_Doc

umen

t_201

5

Simulating Disease States with the Living Heart Human ModelThe Living Heart ProjectSlide Number 3Building the Living Heart Model (LHM)Electrical ResultsMechanical ResultsSlide Number 7LHM Initial HemodynamicsSimulating DiseaseHemodynamic Workflow For Alternate StatesLHM DOE DatabaseDatabase Verification Disease States (1/2)Database Verification Disease States (2/2)Improved Hemodynamic Results for the LHMSummarySlide Number 18Slide Number 19