logistics fact sheets:
TRANSCRIPT
LOGISTICS FACT SHEETS ARV DRUGS
JULY 2008 This publication was produced for review by the United States Agency for International Development It was prepared by the USAID | DELIVER PROJECT Task Order 1
LOGISTICS FACT SHEETS ARV DRUGS
The authors views expressed in this publication do not necessarily reflect the views of the US Agency for International Development or the United States Government
USAID | DELIVER PROJECT Task Order 1 The USAID | DELIVER PROJECT Task Order 1 is funded by the US Agency for International Development under contract no GPO-I-01-06-00007-00 beginning September 29 2006 HIV-related activities of Task Order 1 are supported by the Presidents Emergency Plan for AIDS Relief Task Order 1 is implemented by John Snow Inc in collaboration with PATH Crown Agents Consultancy Inc Abt Associates Fuel Logistics Group (Pty) Ltd UPS Supply Chain Solutions Family Health International The Manoff Group and 3i Infotech The project improves essential health commodity supply chains by strengthening logistics management information systems streamlining distribution systems identifying financial resources for procurement and supply chain operations and enhancing forecasting and procurement planning The project also encourages policymakers and donors to support logistics as a critical factor in the overall success of their health care mandates
Recommended Citation USAID | DELIVER PROJECT Task Order 1 2008 Logistics Fact Sheets ARV Drugs Arlington Va USAID | DELIVER PROJECT Task Order 1
Abstract The antiretroviral (ARV) fact sheets include information critical for informing supply chain management functions for 18 ARV drugs they can be used at all levels of the health system
The sheets list all FDA-approved and WHO-prequalified versions of the drug including the manufacturer strengthform packagingshipping information shelf life recommended storage conditions price and dosage information
Cover photo Used by permission of the Massachusetts HIV Drug Assistance ProgramAIDS Bureau of the Massachusetts Department of Public Health
USAID | DELIVER PROJECT John Snow Inc 1616 Fort Myer Drive 11th Floor Arlington VA 22209 USA Phone 703-528-7474 Fax 703-528-7480 E-mail deliver_projectjsicom Internet deliverjsicom
CONTENTS
Abacavir Sulphate (ABC)1
AbacavirLamivudine (ABC3TC)3
AbacavirLamivudineZidovudine (ABC3TCZDV)4
AbacavirLamivudineZidovudine (ABC3TCZDV)4
Didanosine (ddl)5
Efavirenz (EFV) 8
Efavirenz (EFV) 8
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitabine (FTC)12
Indinavir (IDV)13
Lamivudine (3TC) 14
LamivudineStavudine (3TCd4T)18
LamivudineStavudineNevirapine (3TCD4TNVP) 20
LamivudineStavudine+Efavirenz (3TCd4T+EFV) 22
LamivudineZidovudine (3TCZDV) 23
LamivudineZidovudine+Efavirenz (3TCZDV+EFV)26
LamivudineZidovudineNevirapine (3TCZDVNVP) 28
LopinavirRitonavir (LPVr) 29
Nelfinavir Mesylate (NFV)31
Nevirapine (NVP)32
Ritonavir35
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS v
Saquinavir Mesylate (SQV) 37
Stavudine (d4T) 38
Tenofovir Disoproxil Fumarate (TDF) 43
Zidovudine (ZDV) (AZT) 44
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 vi
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS vii
ABACAVIR SULPHATE (ABC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Ziagen
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709
Tel 1-888-825-5249 wwwgskcom
300 mg tablets 60 tablets per bottle
60 blister packs
Each pack contains blister cards of 10 tablets each
3 years Store at room temperature of 20ndash25degC
$0600 per tablet
$438 per patient per year
20 mgmL oral solution
Bottles of 240 mL 2 years discard 2 months after opening
Store at room temperature of 20degC to 25degC May be refrigerated Do not freeze
$0063 per mL
$229 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 17 May 2006 for tablets and 27 June 06 for oral solution)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
300 mg tablets 60 tablets per bottle
Blisters 10 PVCplain aluminum foil
24 months Store below 25˚C $0542 per tablet
$395 per patient per year
20 mgmL oral solution
Bottles of 240 mL 24 months Store below 25˚C $0085 per mL
$310 per patient per year
Cipla
PEPFAR qualified (Tentatively approved 6 November 2006)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India
(Bangalore site approved by US FDA for bulk drugs)
600 mg tablets (Abamune)
60 tablets per bottle pack
96 packs per shipper
Box dimensions 475 x 375 x 230 mm
24 months Store at 20ndash25˚C $0550 per tablet
$402 per patient per year
300 mg tablets 60 tablets per bottle pack
96 packs per shipper
24 months Store at 20ndash25˚C $0625 per tablet
$456 per patient per year
Box dimensions 475 x 375 x 230 mm
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 1
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LOGISTICS FACT SHEETS ARV DRUGS
The authors views expressed in this publication do not necessarily reflect the views of the US Agency for International Development or the United States Government
USAID | DELIVER PROJECT Task Order 1 The USAID | DELIVER PROJECT Task Order 1 is funded by the US Agency for International Development under contract no GPO-I-01-06-00007-00 beginning September 29 2006 HIV-related activities of Task Order 1 are supported by the Presidents Emergency Plan for AIDS Relief Task Order 1 is implemented by John Snow Inc in collaboration with PATH Crown Agents Consultancy Inc Abt Associates Fuel Logistics Group (Pty) Ltd UPS Supply Chain Solutions Family Health International The Manoff Group and 3i Infotech The project improves essential health commodity supply chains by strengthening logistics management information systems streamlining distribution systems identifying financial resources for procurement and supply chain operations and enhancing forecasting and procurement planning The project also encourages policymakers and donors to support logistics as a critical factor in the overall success of their health care mandates
Recommended Citation USAID | DELIVER PROJECT Task Order 1 2008 Logistics Fact Sheets ARV Drugs Arlington Va USAID | DELIVER PROJECT Task Order 1
Abstract The antiretroviral (ARV) fact sheets include information critical for informing supply chain management functions for 18 ARV drugs they can be used at all levels of the health system
The sheets list all FDA-approved and WHO-prequalified versions of the drug including the manufacturer strengthform packagingshipping information shelf life recommended storage conditions price and dosage information
Cover photo Used by permission of the Massachusetts HIV Drug Assistance ProgramAIDS Bureau of the Massachusetts Department of Public Health
USAID | DELIVER PROJECT John Snow Inc 1616 Fort Myer Drive 11th Floor Arlington VA 22209 USA Phone 703-528-7474 Fax 703-528-7480 E-mail deliver_projectjsicom Internet deliverjsicom
CONTENTS
Abacavir Sulphate (ABC)1
AbacavirLamivudine (ABC3TC)3
AbacavirLamivudineZidovudine (ABC3TCZDV)4
AbacavirLamivudineZidovudine (ABC3TCZDV)4
Didanosine (ddl)5
Efavirenz (EFV) 8
Efavirenz (EFV) 8
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitabine (FTC)12
Indinavir (IDV)13
Lamivudine (3TC) 14
LamivudineStavudine (3TCd4T)18
LamivudineStavudineNevirapine (3TCD4TNVP) 20
LamivudineStavudine+Efavirenz (3TCd4T+EFV) 22
LamivudineZidovudine (3TCZDV) 23
LamivudineZidovudine+Efavirenz (3TCZDV+EFV)26
LamivudineZidovudineNevirapine (3TCZDVNVP) 28
LopinavirRitonavir (LPVr) 29
Nelfinavir Mesylate (NFV)31
Nevirapine (NVP)32
Ritonavir35
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS v
Saquinavir Mesylate (SQV) 37
Stavudine (d4T) 38
Tenofovir Disoproxil Fumarate (TDF) 43
Zidovudine (ZDV) (AZT) 44
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 vi
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS vii
ABACAVIR SULPHATE (ABC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Ziagen
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709
Tel 1-888-825-5249 wwwgskcom
300 mg tablets 60 tablets per bottle
60 blister packs
Each pack contains blister cards of 10 tablets each
3 years Store at room temperature of 20ndash25degC
$0600 per tablet
$438 per patient per year
20 mgmL oral solution
Bottles of 240 mL 2 years discard 2 months after opening
Store at room temperature of 20degC to 25degC May be refrigerated Do not freeze
$0063 per mL
$229 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 17 May 2006 for tablets and 27 June 06 for oral solution)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
300 mg tablets 60 tablets per bottle
Blisters 10 PVCplain aluminum foil
24 months Store below 25˚C $0542 per tablet
$395 per patient per year
20 mgmL oral solution
Bottles of 240 mL 24 months Store below 25˚C $0085 per mL
$310 per patient per year
Cipla
PEPFAR qualified (Tentatively approved 6 November 2006)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India
(Bangalore site approved by US FDA for bulk drugs)
600 mg tablets (Abamune)
60 tablets per bottle pack
96 packs per shipper
Box dimensions 475 x 375 x 230 mm
24 months Store at 20ndash25˚C $0550 per tablet
$402 per patient per year
300 mg tablets 60 tablets per bottle pack
96 packs per shipper
24 months Store at 20ndash25˚C $0625 per tablet
$456 per patient per year
Box dimensions 475 x 375 x 230 mm
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 1
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
USAID | DELIVER PROJECT Task Order 1 The USAID | DELIVER PROJECT Task Order 1 is funded by the US Agency for International Development under contract no GPO-I-01-06-00007-00 beginning September 29 2006 HIV-related activities of Task Order 1 are supported by the Presidents Emergency Plan for AIDS Relief Task Order 1 is implemented by John Snow Inc in collaboration with PATH Crown Agents Consultancy Inc Abt Associates Fuel Logistics Group (Pty) Ltd UPS Supply Chain Solutions Family Health International The Manoff Group and 3i Infotech The project improves essential health commodity supply chains by strengthening logistics management information systems streamlining distribution systems identifying financial resources for procurement and supply chain operations and enhancing forecasting and procurement planning The project also encourages policymakers and donors to support logistics as a critical factor in the overall success of their health care mandates
Recommended Citation USAID | DELIVER PROJECT Task Order 1 2008 Logistics Fact Sheets ARV Drugs Arlington Va USAID | DELIVER PROJECT Task Order 1
Abstract The antiretroviral (ARV) fact sheets include information critical for informing supply chain management functions for 18 ARV drugs they can be used at all levels of the health system
The sheets list all FDA-approved and WHO-prequalified versions of the drug including the manufacturer strengthform packagingshipping information shelf life recommended storage conditions price and dosage information
Cover photo Used by permission of the Massachusetts HIV Drug Assistance ProgramAIDS Bureau of the Massachusetts Department of Public Health
USAID | DELIVER PROJECT John Snow Inc 1616 Fort Myer Drive 11th Floor Arlington VA 22209 USA Phone 703-528-7474 Fax 703-528-7480 E-mail deliver_projectjsicom Internet deliverjsicom
CONTENTS
Abacavir Sulphate (ABC)1
AbacavirLamivudine (ABC3TC)3
AbacavirLamivudineZidovudine (ABC3TCZDV)4
AbacavirLamivudineZidovudine (ABC3TCZDV)4
Didanosine (ddl)5
Efavirenz (EFV) 8
Efavirenz (EFV) 8
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitabine (FTC)12
Indinavir (IDV)13
Lamivudine (3TC) 14
LamivudineStavudine (3TCd4T)18
LamivudineStavudineNevirapine (3TCD4TNVP) 20
LamivudineStavudine+Efavirenz (3TCd4T+EFV) 22
LamivudineZidovudine (3TCZDV) 23
LamivudineZidovudine+Efavirenz (3TCZDV+EFV)26
LamivudineZidovudineNevirapine (3TCZDVNVP) 28
LopinavirRitonavir (LPVr) 29
Nelfinavir Mesylate (NFV)31
Nevirapine (NVP)32
Ritonavir35
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS v
Saquinavir Mesylate (SQV) 37
Stavudine (d4T) 38
Tenofovir Disoproxil Fumarate (TDF) 43
Zidovudine (ZDV) (AZT) 44
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 vi
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS vii
ABACAVIR SULPHATE (ABC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Ziagen
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709
Tel 1-888-825-5249 wwwgskcom
300 mg tablets 60 tablets per bottle
60 blister packs
Each pack contains blister cards of 10 tablets each
3 years Store at room temperature of 20ndash25degC
$0600 per tablet
$438 per patient per year
20 mgmL oral solution
Bottles of 240 mL 2 years discard 2 months after opening
Store at room temperature of 20degC to 25degC May be refrigerated Do not freeze
$0063 per mL
$229 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 17 May 2006 for tablets and 27 June 06 for oral solution)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
300 mg tablets 60 tablets per bottle
Blisters 10 PVCplain aluminum foil
24 months Store below 25˚C $0542 per tablet
$395 per patient per year
20 mgmL oral solution
Bottles of 240 mL 24 months Store below 25˚C $0085 per mL
$310 per patient per year
Cipla
PEPFAR qualified (Tentatively approved 6 November 2006)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India
(Bangalore site approved by US FDA for bulk drugs)
600 mg tablets (Abamune)
60 tablets per bottle pack
96 packs per shipper
Box dimensions 475 x 375 x 230 mm
24 months Store at 20ndash25˚C $0550 per tablet
$402 per patient per year
300 mg tablets 60 tablets per bottle pack
96 packs per shipper
24 months Store at 20ndash25˚C $0625 per tablet
$456 per patient per year
Box dimensions 475 x 375 x 230 mm
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 1
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
CONTENTS
Abacavir Sulphate (ABC)1
AbacavirLamivudine (ABC3TC)3
AbacavirLamivudineZidovudine (ABC3TCZDV)4
AbacavirLamivudineZidovudine (ABC3TCZDV)4
Didanosine (ddl)5
Efavirenz (EFV) 8
Efavirenz (EFV) 8
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitbine + Tenofovir (FTC + TDF) 11
Emtricitabine (FTC)12
Indinavir (IDV)13
Lamivudine (3TC) 14
LamivudineStavudine (3TCd4T)18
LamivudineStavudineNevirapine (3TCD4TNVP) 20
LamivudineStavudine+Efavirenz (3TCd4T+EFV) 22
LamivudineZidovudine (3TCZDV) 23
LamivudineZidovudine+Efavirenz (3TCZDV+EFV)26
LamivudineZidovudineNevirapine (3TCZDVNVP) 28
LopinavirRitonavir (LPVr) 29
Nelfinavir Mesylate (NFV)31
Nevirapine (NVP)32
Ritonavir35
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS v
Saquinavir Mesylate (SQV) 37
Stavudine (d4T) 38
Tenofovir Disoproxil Fumarate (TDF) 43
Zidovudine (ZDV) (AZT) 44
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 vi
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS vii
ABACAVIR SULPHATE (ABC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Ziagen
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709
Tel 1-888-825-5249 wwwgskcom
300 mg tablets 60 tablets per bottle
60 blister packs
Each pack contains blister cards of 10 tablets each
3 years Store at room temperature of 20ndash25degC
$0600 per tablet
$438 per patient per year
20 mgmL oral solution
Bottles of 240 mL 2 years discard 2 months after opening
Store at room temperature of 20degC to 25degC May be refrigerated Do not freeze
$0063 per mL
$229 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 17 May 2006 for tablets and 27 June 06 for oral solution)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
300 mg tablets 60 tablets per bottle
Blisters 10 PVCplain aluminum foil
24 months Store below 25˚C $0542 per tablet
$395 per patient per year
20 mgmL oral solution
Bottles of 240 mL 24 months Store below 25˚C $0085 per mL
$310 per patient per year
Cipla
PEPFAR qualified (Tentatively approved 6 November 2006)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India
(Bangalore site approved by US FDA for bulk drugs)
600 mg tablets (Abamune)
60 tablets per bottle pack
96 packs per shipper
Box dimensions 475 x 375 x 230 mm
24 months Store at 20ndash25˚C $0550 per tablet
$402 per patient per year
300 mg tablets 60 tablets per bottle pack
96 packs per shipper
24 months Store at 20ndash25˚C $0625 per tablet
$456 per patient per year
Box dimensions 475 x 375 x 230 mm
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 1
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Saquinavir Mesylate (SQV) 37
Stavudine (d4T) 38
Tenofovir Disoproxil Fumarate (TDF) 43
Zidovudine (ZDV) (AZT) 44
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 vi
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS vii
ABACAVIR SULPHATE (ABC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Ziagen
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709
Tel 1-888-825-5249 wwwgskcom
300 mg tablets 60 tablets per bottle
60 blister packs
Each pack contains blister cards of 10 tablets each
3 years Store at room temperature of 20ndash25degC
$0600 per tablet
$438 per patient per year
20 mgmL oral solution
Bottles of 240 mL 2 years discard 2 months after opening
Store at room temperature of 20degC to 25degC May be refrigerated Do not freeze
$0063 per mL
$229 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 17 May 2006 for tablets and 27 June 06 for oral solution)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
300 mg tablets 60 tablets per bottle
Blisters 10 PVCplain aluminum foil
24 months Store below 25˚C $0542 per tablet
$395 per patient per year
20 mgmL oral solution
Bottles of 240 mL 24 months Store below 25˚C $0085 per mL
$310 per patient per year
Cipla
PEPFAR qualified (Tentatively approved 6 November 2006)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India
(Bangalore site approved by US FDA for bulk drugs)
600 mg tablets (Abamune)
60 tablets per bottle pack
96 packs per shipper
Box dimensions 475 x 375 x 230 mm
24 months Store at 20ndash25˚C $0550 per tablet
$402 per patient per year
300 mg tablets 60 tablets per bottle pack
96 packs per shipper
24 months Store at 20ndash25˚C $0625 per tablet
$456 per patient per year
Box dimensions 475 x 375 x 230 mm
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 1
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS vii
ABACAVIR SULPHATE (ABC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Ziagen
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709
Tel 1-888-825-5249 wwwgskcom
300 mg tablets 60 tablets per bottle
60 blister packs
Each pack contains blister cards of 10 tablets each
3 years Store at room temperature of 20ndash25degC
$0600 per tablet
$438 per patient per year
20 mgmL oral solution
Bottles of 240 mL 2 years discard 2 months after opening
Store at room temperature of 20degC to 25degC May be refrigerated Do not freeze
$0063 per mL
$229 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 17 May 2006 for tablets and 27 June 06 for oral solution)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
300 mg tablets 60 tablets per bottle
Blisters 10 PVCplain aluminum foil
24 months Store below 25˚C $0542 per tablet
$395 per patient per year
20 mgmL oral solution
Bottles of 240 mL 24 months Store below 25˚C $0085 per mL
$310 per patient per year
Cipla
PEPFAR qualified (Tentatively approved 6 November 2006)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India
(Bangalore site approved by US FDA for bulk drugs)
600 mg tablets (Abamune)
60 tablets per bottle pack
96 packs per shipper
Box dimensions 475 x 375 x 230 mm
24 months Store at 20ndash25˚C $0550 per tablet
$402 per patient per year
300 mg tablets 60 tablets per bottle pack
96 packs per shipper
24 months Store at 20ndash25˚C $0625 per tablet
$456 per patient per year
Box dimensions 475 x 375 x 230 mm
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 1
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
ABACAVIR SULPHATE (ABC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Ziagen
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709
Tel 1-888-825-5249 wwwgskcom
300 mg tablets 60 tablets per bottle
60 blister packs
Each pack contains blister cards of 10 tablets each
3 years Store at room temperature of 20ndash25degC
$0600 per tablet
$438 per patient per year
20 mgmL oral solution
Bottles of 240 mL 2 years discard 2 months after opening
Store at room temperature of 20degC to 25degC May be refrigerated Do not freeze
$0063 per mL
$229 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 17 May 2006 for tablets and 27 June 06 for oral solution)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
300 mg tablets 60 tablets per bottle
Blisters 10 PVCplain aluminum foil
24 months Store below 25˚C $0542 per tablet
$395 per patient per year
20 mgmL oral solution
Bottles of 240 mL 24 months Store below 25˚C $0085 per mL
$310 per patient per year
Cipla
PEPFAR qualified (Tentatively approved 6 November 2006)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India
(Bangalore site approved by US FDA for bulk drugs)
600 mg tablets (Abamune)
60 tablets per bottle pack
96 packs per shipper
Box dimensions 475 x 375 x 230 mm
24 months Store at 20ndash25˚C $0550 per tablet
$402 per patient per year
300 mg tablets 60 tablets per bottle pack
96 packs per shipper
24 months Store at 20ndash25˚C $0625 per tablet
$456 per patient per year
Box dimensions 475 x 375 x 230 mm
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 1
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Matrix Laboratories Inc
Corporate Office Matrix Laboratories Limited 1ndash1-1511 4th Floor Sai Ram Towers
300 mg 60 tablets per bottle
Blister packs 10rsquos
24 months Store below 30˚C $0602 per tablet
$439 per person per year PEPFAR qualified (Tentatively approved 5 April 2007)
Alexander Road Secunderabad ndash 500 003 Phone +91-40-27700363 +91-40-66327722 Fax +91-40-27700343 Email matrixmatrixlabsindiacom
All facilities are USFDA approved
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 600 mg daily or 300 mg twice daily 8 mgkg twice daily (up to maximum of 300 mg twice daily) for Adults ABC + NVP or EFV + PIr adolescent and pediatric patients of 3 months to 16 years of
ABC + ddI or TDF+ PIr age
Children ABC + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 2
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
ABACAVIRLAMIVUDINE (ABC3TC) NRTI
Brand Name Manufacturer
Originator Product
Epzicomreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Research Triangle Park NC 27709 Tel 1-888-825-5249 wwwgskcom
Lamivudine is manufactured under agreement from Shire Pharmaceutical Group plc Basingstoke UK
StrengthForm
Tablet containing
abacavir sulfate 600 mg tablets
lamivudine 300 mg tablets
Packaging amp Shipping Information
30 tablets per bottle
Shelf Life Storage Conditions Price
Store at 25degC (77degF) excursions permitted to 15degndash 30degC (59degndash86degF)
$1858 per tablet
$678 per patient per year
World Health Organization recommended first line regimens Adult Daily Dosage 1 tablet daily Pediatric Daily Dosageusing this ARV
Adults ABC3TC + NVP or EFV
Alternate regimen ABC3TC + AZT or d4T
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 3
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
ABACAVIRLAMIVUDINEZIDOVUDINE (ABC3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Trizivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Ware Hertfordshire UK
Stockley Park West Uxbridge Middlesex UB11 1BT United Kingdom General Enquiries Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
Tablet containing
150 mg lamivudine
300 mg zidovudine
300 mg abacavir
60 tablets per HDPE bottle 24 months Store at 25degC (77degF)
Excursions to 15ndash30degC (59ndash 86degF) permitted
$0895 per tablet
$653 per patient per year
Generic Products
Aurobindo
PEPFAR qualified (Tentatively approved 26 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Co-pack containing 60 + 60 tablets 24 months Store below 25˚C 1417 per tablet
150 mg lamivudine Contains blister card 10 + $517 per patient per year
300 mg zidovudine 10
With PVCPVdCaluminum foil
300 mg abacavir
World Health Organization recommended first line regimens using this ARV
This FDC is recommended as an alternate regimen when a triple NRTI approach because an NNRTI cannot be used
Adult Daily Dosage 1 tablet twice daily Do not administere to adolescents who weigh less than 40 kg
Pediatric Daily Dosage This FDC is not recommended for pediatric patients
Adults ABC + 3TC + ZDV
4 LOGISTICS FACT SHEETS ARV DRUGS JULY 2008
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
DIDANOSINE (ddl) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Videx Videx ECreg
(WHO prequalified)
(FDA approved)
Manufacturer
Bristol-Myers Squibb 3 Rue Joseph Monier BP 325 92506 Reil-Malmaison Cedex France
Tel +33 158 83 60 00 Fax +33 158 83 6565 94 wwwbmscom
125 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
200 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
note Production of 100 mg 150 mg and 200 mg Videx DDI tablets will continue for
250 mg delayed-release capsule
30 capsules per HDPE bottle 24 months
Store capsules in tightly closed containers at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0677 per capsule
$247 per patient per year
ACCESS 400 mg delayedshy 30 capsules per HDPE bottle 24 Store capsules in tightly closed $0874 per countries for the release capsule months containers at 25degC (77degF) capsule next 9 to 12 months
Excursions to 15ndash30degC (59 ndash86degF) permitted
$319 per patient per year
Bristol-Myers Squibb PO Box 4500 Princeton NJ 08543-4500
2 g powder 4 ounce bottles Store between 15ndash30degC $315 per gram
$138 per patient per year
25 mg chewable 60 tablets per HDPE bottle 2 years Store between 15ndash30degC $0235 per tablet tablet $429 per patient
per year
50 mg chewable tablet
60 tablets per HDPE bottle Store between 15ndash30degC $0235 per tablet
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 5
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Generic Product
Didanosine
(FDA approved)
Barr Laboratories Inc Corporate Headquarters 223 Quaker Road Pomona NY 10970
Tel 845-362-1100 -or-
800-222-0190
200 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
Fax 845-362-2774 250 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs
400 mg delayed-release capsule
30 capsules per bottle
12 bottles per case
Shipping carton Dimensions 825 x 65 x 5 in Volume 15 ft3
Weight 16 lbs Didanosine
PEPFAR qualified (Tentatively approved 10 July 2006)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
100 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0150 per tablet
$219 per patient per year
150 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0225 per tablet
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 6
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
200 mg chewable tablet
60rsquos per HDPE container 24 months
Store below 25˚C $0308 per tablet
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 400 mg for patients ge 60 kg in combination with other gt 3 months 50 mgm2 twice daily
antiretroviral agents Adults 3 to 13 years 90ndash120 mgm2 twice daily
Second line ddI + ABC or 3TC (plusmn AZT) + PIr Alternate second line regimen ddI + EFV or NVP + PIr
250 mg for patients le 60 kg in combination with other antiretroviral agents
Maximum dose 200 mgdose twice daily
Children Videx EC should not be used by pediatric Second line ddI + ABC or AZT or EFV or NVP + PIr patients
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 7
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
EFAVIRENZ (EFV) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Sustivacopy
(FDA approved)
Bristol-Myers Squibb Princeton NJ 08543 USA
50 mg capsule 30 capsules per bottle 36 months Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0116 per capsule
$169 per patient per year
Internationally marketed as Stocrin licensed by Merck
Tel +1 800 426 7644 +1 800 631 5244
wwwbmscom
200 mg capsule 90 capsules per bottle 3 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$0457 per capsule
$500 per patient per year
600 mg film-coated tablet
30 tablets per bottle 2 years Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
$095 per tablet
$347 per patient per year
100 mg capsule 30 tablets per bottle Store at 25degC (77degF) excursions to 15ndash30degC (59ndash 86degF) permitted
Generic Product
Efavir Cipla 600 mg capsule 600 mg bottle 24 months Store between 20ndash25˚C $0467 per capsule
96 packs per shipper
30rsquos bottle pack
$170 per patient per year
500rsquos bottle pack
Ranbax Labs 600 mg tablets 60rsquos HDPE bottle 24 months Store below 25˚C $02083 per tablet
Sahib India 10rsquos cold form blister pack
Tel +91(1704)222834 222720 10rsquos PVdCPEPVC blister 222719 pack
60rsquos HDPE bottle
10rsquos cold form blister pack
24 months Store below 25˚C in original package
$02500 per tablet200 mg tablets
10rsquos PVdCPEPVC blister pack
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 8
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Stocrin Merck Sharp amp Dohme (Australia) Pty Limited ABN 14 000 173 508 54-68 Ferndell Street SOUTH GRANVILLE NSW
50 mg tablet 30 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
2142 200 mg tablet 90 capsules per bottle 36 months
One month after opening bottle
Store in a cool dry place where the temperature stays below 30degC
Strides S-No 367 Suragajkkanahalli Indlavadi Cross Anekal Taluk Banglore-562106 India
600 mg tablets 20 tablets per bottle 24 months Store below 30˚C
Protect from light and keep in closed container
$0500 per pill
$18000 per patient per year
Matrix 600 mg tablets 30 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $13 per bottle
Viranzcopy
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
600 mg capsules 30 capsules per bottle
30 capsules per bottle
90 capsules per bottle
30 capsules per bottle
24 months
24 months
24 months
24 months
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
Do not store above 25degC Store in original package
$55 per tablet
$201 per patient per year
$0175 per capsule
$0206 per capsule
$226 per patient per year
$0093 per capsule
100 mg capsules
200 mg capsules
50 mg capsules
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 9
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
World Health Organization recommended first and Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 600 mg daily in combination with a protease inhibitor andor nucleoside 10 to lt 14 kg 200 mg
analogue reverse transcriptase inhibitors 14 to lt 20 kg 250 mg Adults 20 to lt 25 kg 300 mg First line EFV + 3TC o r FTC + AZT or d4T or TDF or 25 to lt 30 kg 350 mg
ABC 30 to lt 40 kg 400 mg Alternate second line EFV + PIr + ddI gt40 kg 600 mg
Children First line EFV + 3TC + AZT or d4T or ABC Second line EFV + ddI + PIr
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 10
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
EMTRICITBINE + TENOFOVIR (FTC + TDF) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Truvada Gilead Sciences Inc Tablet contains HDPE bottle with 30 tablets Store below 25degC (77degF) $0875 per tablet 333 Lakeside Drive Foster City California 94404 USA
200 mg emtricitabine
300 mg tenofivir $319 per patient per year
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV One tablet of 3TC AZT twice a daily and one Formulation is not designed for children Adults FTC+ AZT or d4T + EFV or NVP tablet of EFV daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 11
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
EMTRICITABINE (FTC) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Emtriva
(FDA approved)
Gilead Sciences Inc 333 Lakeside Drive Foster City California 94404 USA
Tel +1-650-574-3000 Fax +1-650-522-5870 E-mail ARVaccess gileadcom wwwgileadcom
200 mg capsule 30 capsules per bottle
30 capsules per blister pack
2 years Store at room temperature between 39ndash 86degF (15ndash30degC)
10 mgmL oral solution
170 mL bottles including a marked dosing cup
3 years 45 days after first opening the bottle
Store in refrigerator between 36ndash46degF (2ndash 8degC) Alternatively can be stored at room temperature (25degC) for three months Discard any remaining solution after 3 months
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV One 200 mg capsule once daily in combination gt4 months 6 mgkg up to a maximum of 240 mg Adults FTC + AZT or d4T or TDF or ABC + EFV or with other antiretrovirals once daily in combination with other antiretrovirals NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 12
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
INDINAVIR (IDV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Crixivan Merck and Co Inc 400 mg capsule Bottles of 18 42 90 120 3 years Store at room $274 per capsule One Merck Drive 180 capsules with dessicant temperature 15ndash30degC
(FDA approved) Whitehouse Station NJ 08889 (59ndash86degF) $400 per patient per year
Tel 908-423-1000 Protect from moisture wwwmerckcom
World Health Organization recommended second line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 800 mg (or two 400 mg capsules) every 8 hours Optimal dosing for pediatric patients has not been Adults IDV r + ddI or TDF + ABC or 3TC (plusmnAZT) in combination with other antiretrovirals established
Alternate second line IDV r + ddI + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 13
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LAMIVUDINE (3TC) NRTI
Packaging amp Shipping Shelf Brand Name Manufacturer StrengthForm Information Life Storage Conditions Price
Originator Product
Epivirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328 wwwgskcom
150 mg tablet 60 tablets per HDPE bottle
60 tablets per blister pack
600 tablets per inner carton
Shipping carton Volume 06 ft3
24 months Store at 25degC (77degF) Excursions to 15ndash30degC (59ndash86degF) permitted
$0087 per tablet
$64 per patient per year
GlaxoSmithKline 10 mgmL syrup 240 mL per HDPE bottle 24 months Do not store above 25degC $0023 per mL Stockley Park West Uxbridge Middlesex UB222BT Tel +44 (0) 8 0021441 Fax +44 20 8990 4328
12 bottles per inner carton
10 mL oral dosing syringe and polyethylene adapter included
Discard oral solution one month after opening
$84 per patient per year
wwwgskcom Shipping carton Volume 37 ft3
Generic Products
Heptavir Hetero Drugs Ltd 150 mg tablet 60 tablets per HDPE bottle Do not store above 30degC $0073 per tablet Jeedimetla AP India
$53 per patient per year 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
+91 40 2371 4250 wwwheterodrugscom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 14
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Lamivirreg
(WHO prequalified)
Cipla Ltd Vikhroli India
Mumbai Central Mumbaindash400 008
50 mg5 mL solution 100 mL per PET bottle with syringe
240 mL bottle
35 bottles per shipper
24 months Store between 20ndash25˚C
Discard oral solution one month after opening
$0018 per mL
$66 per patient per year
India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
100 mg tablet 10 tablets per blister pack
60 tablets per inner carton
24 months Do not store above 30degC
+91 22 2307 0393 wwwciplacom
150 mg tablet 10 tablets per blister pack
60 tablets per inner carton
168 packs per shipping carton
Shipping carton Dimensions 455 x 280 x 250 mm Weight 151 kg
24 months Do not store above 30degC $0065 per tablet
$47 per patient per year
Lamivudine
(WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
150 mg tablet 60 tablets per HDPE bottle
10 tablets per blister pack
Do not store above 30degC $0071 per tablet
$5112 per patient per year
Lamivox
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal
150 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0059 tablet
$43 per patient per year
(FDA tentatively approved)
Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$155 per tablet
$56 per patient per year
10 mgmL 240 mL HDPE container
Pack contains a 20 mL measuring cup
18 months Do not store above 25degC $0009 per mL
$34 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 15
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
continued LAMIVUDINE
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Aspen Lamivudine
(WHO prequalified)
Aspen Pharmacare Aspen Park 98 Armstrong Avenue La Lucia Ridge Durban 4019 South Africa
150 mg tablet 60 tablets per plastic container securitainer metalised lay flat pack glass bottle
24 months Store below 25˚C $450
Tel +27 31 5808600 wwwaspenpharmacom
Matrix 150 mg tablet 60 tablets per bottle
126 bottles per shipper
24 months Store below 30˚C $320 per bottle
Anolam Virolam Avolam
(FDA tentatively approved)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
150 mg tablet 60 tablets per bottle
1440 tablets per inner carton (24 packs per inner carton)
14400 tablets per shipping carton (600 packs or 10 inner carton)
Shipping carton Dimensions 49 x 36 x 23 m Volume 0406 Weight 785
24 months Store below 25degC
Protect from moisture
$00517 per tablet
$43 per patient per year
World Health Organization recommended first and Adult Daily Dosage 300 mg daily or 150 mg twice daily in Pediatric Daily Dosage second line regimens combination with other antiretroviral agents lt 30 days 2 mgkg twice daily regimens using this ARV
gt 30 days to 12 years 4 mgkg twice daily up to a Adults Per Cipla adults weighing less than 50 kg 150 mg once daily maximum of 150 mg twice daily First line 3TC + AZT or d4T or TDF or ABC + EFV or NVP
Alternate first line 3TC + AZT or d4T + TDF or ABC Second line 3TC + ddI or TDF + PIr
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 16
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Children First line 3TC + AZT or d4T or ABC + NVP or EFV Alternate first line 3TC + AZT or d4T + ABC
PIr = ATVr FPVr IDVr LPVr and SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 17
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LAMIVUDINESTAVUDINE (3TCd4T) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
Virolis 30
Coviro - LS 30
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
19 Nehru Place New Delhindash110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle
10 blister pack
24 months Store below 25degC
Protect from moisture
$00750 per tablet $124 per patient per year
Cipla Tablet containing 30rsquos bottle pack 24 months Store between 15ndash25˚C $0075 per capsule
150 mg lamivudine 1000rsquos bottle pack $5500 per patient per year
30 mg stavudine 96 pack per shipper
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C $425 per bottle
150 mg lamivudine 168 bottles per shipper
30 mg stavudine
Lamivudine Stavudine (WHO prequalified)
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine 30 mg stavudine
60 tablets per bottle 24 months Store below 30degC
Protect from sunlight
$0075 per tablet $54 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 18
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV Patients ge 60 kg one 3TCd4T (40 mg) Patients ge 37 kg one 3TCd4T (30 mg) tablet twice Adults tablet twice daily in combination with other daily
First line d4T3TC + NVP or EFV antiretroviral agents
Alternate first line d4T3TC + TDF or ABC Patients lt 60 kg one 3TCd4T (30 mg) tablet twice daily in combination with other
Children antiretroviral agents d4T3TC + NVP or EFV
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 19
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LAMIVUDINESTAVUDINENEVIRAPINE (3TCD4TNVP) NRTI amp NNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Originator Product
Generic Product
Triomune 30
(WHO prequalified)
Cipla Ltd Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Tablet containing 200 mg nevirapine
150 mg lamivudine
30 mg stavudine
30 tablets per bottle
60rsquos bottle pack
1000rsquos bottle pack
Container of 60 tablets
60 bottle pack
24 months
18 months
24 months
Store between 15ndash25˚C Protect from moisture
Store below 25˚C
Store between 15ndash25˚C
$0142 per tablet
$103 per patient per year
Each tablet contains stavudine 6 mg lamivudine 30 mg nevirapine 50 mg Tablet containing
lamivudine 60 mg 1000 bottle pack
stavudine 12 mg
nevirapine 100 mg
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
lamivudine 150 mg
stavudine 40 mg
nevirapine 200 mg
30 tablets 24 months Store below 30˚C
Protect from light
$014 per tablet
$10200 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 20
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Virolans 30 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryana) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
60 tablets per bottle 240 tablets per case 2400 tablets per shipping carton
Shipping carton Dimensions 45 x 03 x 025 m
12 months Store below 25degC Protect from moisture
$01283 per tablet
$219 per patient per year
wwwranbaxycom Volume 00338 m3
Weight 485
Virolans 40 Triviro - LNS
(WHO prequalified)
Ranbaxy Laboratories Ltd Dewas India
Plot 90 Sector 32 Gurgaon -122001 (Haryan a) India Tel +91 124 5135000
Tablet containing 200 mg nevirapine 150 mg lamivudine 40 mg stavudine
60 tablets per bottle
240 tablets per case
2400 tablets per shipping carton
12 months Store below 25degC Protect from moisture
$01333 per tablet
$234 per patient per year
wwwranbaxycom Shipping carton Dimensions 45 x 03 x 025 m Volume 00338 Weight 485
Nevilast 30
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500 018 (AP) India q Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing 200 mg nevirapine 150 mg lamivudine 30 mg stavudine
10 tablets per blister pack
60 tablets per HDPE bottle $201 per tablet
$147 per patient per year
23714250 wwwheterodrugscom
World Health Organization recommended first line regimens using this ARV
Adults d4T3TCNVP
Children d4T3TCNVP
Adult Daily Dosage 1 tablet twice daily of 40 mg for patients gt 60 kg and 1 tablet twice daily of 30 mg for patients lt 60 kg in combination with other antiretroviral agents
Pediatric Daily Dosage The FDC is not recommended for pediatric patients or patients lt 50 kg
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 21
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LAMIVUDINESTAVUDINE+EFAVIRENZ (3TCd4T+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (coshy 24 months Store at room Stavudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
stavudine 30 mg
Plus
blister pack)
HDPE bottle
temperature 25degC
Co-blister pack wwwstridesarcocom Tablet containing
(WHO pre-qualified)
efavirenz 600 mg
(FDA tentatively approved )
Lamivudine Stavudine
Plus
Efavirenz
Co-blister pack
(WHO pre-qualified)
(FDA tentatively approved )
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
stavudine 30 mg
Plus
Tablet containing
efavirenz 600 mg
60 tablets + 30 tablets (co-blister pack)
HDPE bottle
24 months Store below 30degC $0945 per daily dose (3 tabs)
$345 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCd4T one twice daily Adults 3TC+ d4T +EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 22
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LAMIVUDINEZIDOVUDINE (3TCZDV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Combivirreg GlaxoSmithKline Tablet containing 60 tablets per bottle 24 months Store between 2ndash30degC $0325 per tablet
(FDA approved)
by Shire Pharmaceuticals Group Inc
150 mg lamivudine (36ndash86degF) $237 per patient per
(WHO
Baingstoke UK 300 mg zidovudine 60 tablets per HDPE bottle
year
prequalified)
Generic Products
Zidolam Hetero Drugs Ltd Jeedimetla AP India
16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
Tablet containing
150 mg lamivudine
300 mg zidovudine
10 tablets per blister pack
60 tablets per HDPE bottle
Do not store above 30degC
$0220 per tablet
$160 per patient per year
+91 40 23714250 wwwheterodrugscom
Matrix Tablet containing 60 tablets per bottle 24 months Store below 30˚C
150 mg lamivudine 168 bottles per carrier
300 mg zidovudine
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346 wwwstridesarcocom
Tablet containing
150 mg lamivudine
300 mg zidovudine
60 tablets per bottle 24 months Store below 30˚C
Protect from light
$0210 per tablet
$15120 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 23
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Avocomb Ranbaxy Laboratories Ltd Tablet containing 60 tablets per bottleblister pack 24 months Store below 25degC $01667 per tablet
Virocomb Dewas India Plot 90 Sector 32 Gurgaon -122001 (Haryana)
150 mg lamivudine 300 mg zidovudine
10 cold form blister pack
10 PVdCPVC blister pack
Protect from moisture $140 per patient per year
(WHO prequalified)
India Tel +91 124 5135000 wwwranbaxycom
Pharmacare Tablet containing
150 mg lamivudine
300 mg zidovudine
120 tablets per carton 24 months Store below 25˚C
Protect from moisture and light
Lamivudine Zidovudine
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India
Tablet containing
150 mg lamivudine 300 mg zidovudine
60 tablets per bottle 24 months Do not store above 30degC Store in original package
$0192 per tablet
$140 per patient per year
(WHO prequalified)
Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
Duovir
(WHO prequalified)
Cipla Ltd Vikhroli India Patalganga India
Mumbai Central Mumbaindash400 008 India Tel +91 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393
Tablet containing
150 mg lamivudine 300 mg zidovudine
10 blister packs
60 tablets per container
1000 tablets per bottle pack
Shipping carton Dimensions 305 x 270 x 150 mm Weight 25 kg
24 months Store 20ndash25˚C $0183 per tablet
$134 per patient per year
wwwciplacom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 24
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
World Health Organization recommended first line regimens using this ARV Adult and adolescent Daily Dosage Pediatric Daily Dosage This FDC Adults 3TCAZT + EFV or NVP One tablet twice daily in combination with should not be used by pediatric patients
Alternate first line 3TCAZT + TDF or ABC other antiretroviral agents under 12 years of age
Children 3TCAZT + EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 25
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LAMIVUDINEZIDOVUDINE+EFAVIRENZ (3TCZDV+EFV) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Lamivudine Strides Arcolab Ltd Tablet containing 60 tablets + 30 tablets (co- Store at room $904 per daily dose (3 Zidovudine
Plus
Efavirenz
Strides House Bilekahalli Bannerghatta Rd Bangalore-560076 India Tel +91 80 658134346
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
HDPE bottle
temperature 30˚C tabs)
$330 per patient per year
Co-blister pack wwwstridesarcocom Tablet containing
efavirenz 600 mg (WHO pre-qualified)
(FDA tentatively approved )
Lamivudine Aurobindo Pharma Ltd Tablet containing 60 tablets + 30 tablets (coshy $1083 per daily dose (3 Zidovudine
Plus
Efavirenz
Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038
lamivudine 150 mg
zidovudine 300 mg
Plus
blister pack)
Blister cards carton
tabs)
$395 per patient per year
Co-blister pack Andhra Pradesh India Phone +91 (40) Tablet containing
Fax +91(40) 2374 1080 2374 efavirenz 600 mg (WHO preshy 6883 qualified) Email infoaurobindocom
(FDA tentatively approved)
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 26
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Lamivudine Zidovudine
Plus
Efavirenz
Co-blister pack
(WHO pre qualified)
Ranbaxy Laboratories Ltd Dewas India 19 Nehru Place New Delhi-110019 India Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
Plus
Tablet containing
efavirenz 600 mg
AluAlu blister 2 + 1 Cardboard box 30 + 15
$105 per daily dose (3 tabs)
$434 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDV one twice daily Adults 3TC+ZDV+EFV EFV once daily
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 27
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LAMIVUDINEZIDOVUDINENEVIRAPINE (3TCZDVNVP) NRTIampNRTIampNNRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Duovir N
(FDA tentatively approved)
Cipla Ltd Mumbai Central Mumbai 400 ndash8 India (Bangalore site approved by US FDA for bulk drugs)
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets HDPE bottles with child resistant closure
Store below 25degC $0317 per tablet
$231 per patient per year
Lamivudine Zidovudine Nevirapine
(FDA tentatively approved)
Aurobindo Pharma Ltd Registered amp Corporate Office Plot 2 Maitri Vihar Ameerpet Hyderabad ndash 500 038 Andhra Pradesh India Phone +91 (40) Fax +91(40) 2374 1080 2374 6883 Email infoaurobindocom
Tablet containing
lamivudine 150 mg
zidovudine 300 mg
nevirapine 200 mg
60 tablets 24 months Store below 25degC $0242 per tablet
$176 per patient per year
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 3TCZDVNVP one twice daily Not for children Adults 3TC+ZDV+NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 28
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LOPINAVIRRITONAVIR (LPVr) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Kaletrareg
(WHO prequalified)
(FDA approved)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100 wwwabbottcom
(check the website for local
Capsule containing 1333 mg lopinavir
333 mg ritonavir
2 x 90 capsules per HDPE bottle
Shipping carton 6 bottles per inner carton Weight 184 kg
24 months Store capsules at 2ndash8degC (36ndash46degF) until dispensed Avoid exposure to excessive heat If stored at room temperature up to 25degC (77degF) use capsules within 2 months
$0228 per capsule
$500 per patient per year
distributors) Oral solution 160 mL per PET bottle 24 months Store oral solution at 2ndash $0137 per mL containing 8degC (36ndash46degF) until
Abbott Laboratories Queensborough Kent UK
80 mgmL lopinavir
20 mgmL ritonavir
60 mL per PET bottle
Five 60 mL bottles with 5
dispensed Avoid exposure to excessive heat If stored at room
$200 per patient per year
Abbott House Norden Road Maidenhead Berkshire SL6 4XE England
(Oral solution contains 424 vv alcohol)
mL syringes per pack temperature up to 25degC (77degF) use solution within 2 months
Tel +44 1628 773 355 Fax +44 1628 644 305 wwwabbottukcom
Aluviareg
(WHO prequalified)
Abbott Laboratories 100 Abbott Park Road Abbott Park Illinois 60064shy3500 Telephone (847) 937-6100
Tablet containing 200 mg lopinavir
50 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0342 per capsule
$500 per patient per year
(FDA approved) wwwabbottcom
(check the website for local distributors)
Tablet containing 100 mg lopinavir
25 mg ritonavir
120 tablets per HDPE bottle Store tablets at room temperature up to 25degC Excursions permitted to 15ndash30degC
$0171 per capsule
$125 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 29
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
World Health Organization recommends LPVr be Adult Daily Dosage Pediatric Dosage used for second line regimens 3 capsules OR 2 tablets twice daily OR 5 mL 5 ndash 79 kg 16 mg3 mgkg twice daily
in combination with other antiretroviral agents 8 ndash 99 kg 14 mg3 mgkg twice daily Adults
10 ndash 139 kg 12 mg3 mgkg twice daily Second line LPVr + TDF or ddI + ABC or 3TC (plusmn AZT)
14 ndash 399kg 10 mg25 mgkg twice daily Alternate second line LPVr + ddI + EFV or NVP
Maximum dose 400 mg 100 mg twice daily
Children LPVr + ddI + ABC or AZT or EFV or NVP Prescriber should calculate the appropriate milligram dose for each individual child lt13 years old and determine the corresponding volume of solution or number of capsules
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 30
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
NELFINAVIR MESYLATE (NFV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viraceptreg
(WHO has temporarily suspended this product from the pre-qualification list due to a recall in 2007)
Roche 250 mg tablet 300 tablets per plastic container
3 years Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0293 per tablet
$1069 per patient per year
625 mg tablet 120 tablets per HDPE bottle 3 years Store at 15ndash25degC (59ndash 77degF) in tightly closed container
50 mgg oral powder 144 g per HDPE bottle with scoop
2 years Store at 15ndash25degC (59ndash 77degF) Store in the original
$0220 per dose
(FDA approved) package
$1927 per patient per year
World Health Organization recommends NFV be Adult Daily Dosage Pediatric Daily Dosage used in second line regimens Tablets 1250 mg (as five 250 mg tablets or lt 10kg ~ 75 mgkgdose twice daily
Adults two 625 mg tablets) twice daily in combination with other antiretroviral agents
gt 10kg to 199 kg ~ 60 mgkgdose twice daily
Maximum dose of 1250 mg twice daily in combination Second line NFV + TDF or ddI + ABC or 3TC (plusmn AZT) with other antiretroviral agents Alternate second line NFV + ddI + EFV or NVP
Children NFV + ddI + ABC or AZT or EFV or NVP
NFV is not the first choice for PIs as it is considered less potent than the ritonovir boosted PIs
Price packaging and shipping information will vary according to contract specifications Source Source Meacutedecins Sans FrontiegraveresJune 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 31
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
NEVIRAPINE (NVP) NNRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Viramunereg
(WHO prequalified)
Boehringer Ingelheim Binger Str 173 55216 Ingelheim Germany
200 mg tablet 10 tablets per blister pack
6 blister packs per carton
24 months Store at 25degC (77degF) excursions permitted to 15degndash30degC (59ndash86degF)
$0300 per tablet
$219 per patient per year
(FDA approved) Tel +49 6132 77 0 Fax +49 6132 72 0 httpwwwboehringershyingelheimcom
Boehringer Ingelheim 50 mg5 mL oral 240 mL per HDPE bottle + 5 mL syringe 24 months Store at 25degC (77degF) $0052 per mL Roxane Laboratories Inc suspension excursions permitted to Columbus OH USA Use product 15ndash30degC (59ndash86degF) $1248 per bottle
within 2 PO Box 16532 months of $380 per patient Columbus OH 43216-6532 opening per year USA
Tel +1-614-276-4000 httpwwwboehringershyingelheimcom
Generic Products
Nevimune
(WHO prequalified)
(FDA tentatively approved)
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
200 mg tablet
32 LOGISTICS FACT SHEETS ARV DRUGS
1000 per bottle pack
Shipping carton Dimensions 45 x 28 x 2 m Volume 0252 m3
Weight 104 kg
24 months $0068 per tablet
$50 per patient per year
JULY 2008
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevipan Ranbaxy Laboratories Ltd Dewas India
200 mg tablet 60 tablets per blister stripbottle 24 months Store below 25degC $00633 per tablet
(FDA tentatively approved) 19 Nehru Place
New Delhindash110019 India
1500 tablets per inner carton
6000 tablets per shipping carton
Protect from moisture $52 per patient per year
Tel +91 11 2645 2666-72 Fax +91 11 2600 2076 wwwranbaxycom
Shipping carton Dimensions 053 x 035 x 029 m Volume 00538 m3
Weight 9 kg
Nevivir
(WHO prequalified)
Hetero Drugs Ltd 16671 Erragadda Hyderabadndash500018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926
200 mg tablet 10 tablets per blister pack
60 tablets per HDPE bottle
Store below 30degC $0066 per tablet
$48 per patient per year
+91 40 2371 4250 wwwheterodrugscom
Nevirapine Strides Arcolab Ltd Strides House Bilekahalli
200 mg tablet 60 tablets per HDPE bottle $008 per tablet
(WHO prequalified)
Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346
$58 per patient per year
wwwstridesarcocom
Nevirex
(FDA tentatively approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
2374 6883 wwwaurobindocom
200 mg tablet 60 tablets per HDPE bottle 24 months Do not store above 25degC Store in original package
$0066 per tablet
$48 per patient per year
50 mg5 mL oral suspension
240 mL per HDPE bottle
The pack contains a 20 mL measuring cup
24 months Do not store above 25degC Store in original package
$0010 per mL
$76 per patient per year
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 33
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
Nevirapine
(FDA tentatively approved)
Zhejiang Huahai Pharmaceutical Co Ltd Xunqiao Linhai Zhejiang 317024 China
enhuahaicom
200 mg tablet 60 tablets per HDPE bottle 24 months Store below 25˚C
Excursions permitted 15ndash30˚C
Nevirapine
(FDA tentatively approved)
Emcure Pharmaceuticals Limited Plot No P-2 IT-BT Park Phase II MIDC Hinjwadi Pune 411 057 India
wwwemcurecoin
200 mg tablet 60 tablets per HDPE bottle 10 tablets per blister
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage regimens using this ARV 200 mg daily for the first 14 days followed by 200 mg twice 2 months to 8 years 4 mgkg once daily for two weeks Adults daily in combination with other antiretroviral agents followed by 7 mgkg once daily thereafter First line NVP + 3TC or FTC + AZT or d4T
Nevirapine is the first choice NNRTI during pregnancy Preferred regimen for pregnant women or for women for
8 years to 16 years 4 mgkg once daily for two weeks followed by 4 mgkg twice daily thereafter
whom effective contraception cannot be assured Total daily dose should not exceed 400 mg
Alternate second line NVP + ddI + PIr
Children NVP + AZT or d4T or ABC + 3TC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 34
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
RITONAVIR PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Norvir
(WHO prequalified)
Abbott Laboratories Abbott Park Illinois USA
Tel 800-323-9100
100 mg capsule 84 capsules per HDPE bottle
4 bottles per pack
2 years Store in refrigerator between 2ndash8degC Can be stored below 25degC if used within 30 days by patient
$0114 per capsule
$83 per patient per year
wwwabbottcom 80 mgmL oral 90 mL per PET bottle 6 months Store below 25degC Do $093 per mL (FDA approved) solution not refrigerate or freeze
$79 per patient per year
World Health Organization recommends that Adult Daily Dosage Pediatric Daily Dosage ritonavir be used in some second line regimens in combination with protease Inhibitors
600 mg (or 6 capsules) twice daily in combination with other antiretrovirals
gt 2 years 350 mgm2 twice daily in combination with other antiretrovirals
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 35
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 36
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
SAQUINAVIR MESYLATE (SQV) PI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Invirase
(FDA approved)
F Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland Tel +41-61-688 111 wwwrochecom
200 mg capsules 270 capsules per HDPE bottle
3 years Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0288 per capsule
$1051 per patient per year
Roche Labs Inc 340 Kingsland Street Nutley NJ 07110-1199 wwwrochecom
500 mg tablets 120 tablets per HDPE bottle Store at 25degC Excursions permitted to 15ndash30degC Store in tightly closed bottles
$0663 per tablet
$968 per patient per year
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage second line regimens using this ARV 1000 mg twice daily (either five 200 mg capsules or two 500 The safety of saquinavir in pediatric patients under 16 Adults mg tablets) in combination with ritonavir years old or under 25 kg has not been determined
Second line SQVr + TDF or ddI + ABC or 3TC (plusmn AZT)
Alternate second line SQVr + ddI + EFV or NVP
Children
First line SQVr + ddI + ABC or AZT or EFV or NVP
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres June 2005 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 37
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
STAVUDINE (d4T) NRTI
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Originator Product
Zeritreg Bristol Myers Squibb 15 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed $0032 per PO Box 4500 containers at controlled room capsule
(WHO prequalified)
Princeton NJ 08543-4500 Tel 800-321-1335 wwwbmscom
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC)
(FDA approved) Do not store above 30degC
20 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$69 per patient per
Do not store above 30degC year
30 mg capsule 56 capsules per blister pack
60 capsules per HDPE bottle
24 months Store capsules in tightly closed containers at controlled room temperature 59ndash86degF (15ndash 30degC)
$0092 per capsule
$67 per patient per
Do not store above 30degC year
40 mg capsule 56 capsules per blister pack 24 months Store capsules in tightly closed containers at controlled room
$0092 per capsule
60 capsules per HDPE bottle temperature 59ndash86degF (15ndash 30degC) $67 per
patient per Do not store above 30degC year
Zeritreg
(continued)
(WHO prequalified)
(FDA approved)
1 mgmL oral solution
Container provides 200 mL of solution after reconstitution with water
2 years discard unused solution after 30 days
Store powder at 59ndash86degF (15ndash 30degC) and protect from excessive moisture
After reconstitution store the solution in a tightly closed container at 2ndash8degC
$0007 per mL
$51 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 38
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
continued STAVUDINE (d4T)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
Generic Products
Stag Hetero Drugs Ltd Genex Pharma
30 mg capsule 10 capsules per blister pack $0027 per capsule
Mumbai India 60 capsules per bottle $20 per
16671 Erragadda patient per Hyderabadndash500018 year (AP) India Tel +91 237049232425 Fax +91 40 23704926 23714250 wwwheterodrugscom
40 mg capsule 10 capsules per blister pack
60 capsules per bottle
$0033 per capsule
$24 per patient per year
Virostav Avostav
Ranbaxy Laboratories Ltd India
19 Nehru Place New Delhindash110019 India Tel +91 11 26452666 72 Fax +91 11 26002076
30 mg capsule 60 capsules per bottle or blister pack 180 capsules per case (3 bottles) 1800 capsules per shipping carton (30 bottles)
Shipping carton Dimensions 049 x 039 x 025 m
24 months Store below 25degC
Protect from moisture
$0040 per capsule
$28 per patient per year
wwwranbaxycom Volume 00478 m3
Weight 28 kg
40 mg capsule 60 capsules per bottle or blister pack 24 months Store below 25degC $0045 per capsule
Shipping carton Dimensions 035 x 029 x 027 m Volume 00274 m3
Weight 27 kg
Protect from moisture $34 per patient per year
Stavex
(tentatively FDA approved)
(WHO prequalified)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Ranga Reddy District Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080
15 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0031 per capsule
20 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0033 per capsule
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 39
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information
Shelf Life Storage Conditions Price
2374 6883 wwwaurobindocom
30 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 25degC $0037 per capsule
$27 per patient per year
40 mg capsule 60 capsules per HDPE bottle 24 months Do not store above 30degC $0040 per capsule
$29 per patient per year
1 mgmL oral solution
200 mL HDPE bottle and measuring cup 24 months for dry powder and not more than 30 days following reconstitushytion
Do not store powder above 30degC Following reconstitution store the solution in tightly closed bottles between 2ndash8degC
$0010 per ml
$73 per patient per year (daily dose 20 ml)
Aspen-Stavudine
Aspen Pharmacare Aspen Park 98 Armstrong Avenue
40 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
(WHO prequalified)
La Lucia Ridge Durban 4019 South Africa Tel +27 31 5808600 wwwaspenpharmacom
30 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
20 mg capsules 60 capsules per plastic container securitainer metallised lay flat pack glass bottle
24 months Store below 25˚C Protect from moisture and light
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 40
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name
Stavudine
(WHO prequalified)
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Stavudine
(FDA tentatively approved)
Manufacturer
Strides Arcolab Ltd Strides House Bilekahalli Bannerghatta Road Bangalorendash560076 India Tel +91 80 658134346 wwwstridesarcocom
Cipla Ltd Vikhroli India Goa India
Mumbai Central Mumbai 400 008 India Tel +91 22 2308 2891
+91 22 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
StrengthForm Packaging amp Shipping Information
30 mg capsule 60 capsules per HDPE bottle
1mg mL oral solution
200 ml HDPE bottles
30 mg capsules 60 capsules per HDPE bottle 10 capsules per Blister Pack
40 mg 60 tablets per bottle
90 bottles per shipper
Shelf Life
24 months
24 months
24 months
24 months
Storage Conditions
Store below 30degC
Store at 20ndash25˚C
Store below 30˚C
Store below 30˚C Protect from light
Price
$0037 per capsule
$2664 per patient per year
$0015 per ml
$110 per person per year
$0042 per capsule
$31 per patient per year
$250 per bottle
World Health Organization recommended Adult Daily Dosage Pediatric Daily Dosage first line regimens using this ARV 30 mg twice daily for patients in combination Birth to 13 days old 05 mgkgdose Adults with other antiretroviral agents every 12 hours First line d4T + 3TC or FTC + NVP or EFV 14 days old and le 30 kg 1 mgkgdose
every 12 hoursAlternate first line d4T + 3TC or FTC + TDF or ABC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 41
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Children d4T + 3TC + NVP when child lt 3 years or lt 10 kg
d4T + 3TC + EFV when child gt 3years
Alternate first line d4T + 3TC + ABC
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 42
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
TENOFOVIR DISOPROXIL FUMARATE (TDF) NRTI
Packaging amp Shipping Storage Brand Name Manufacturer StrengthForm Information Shelf Life Conditions Price
Originator Product
Vireadreg Gilead Sciences Inc 333 Lakeside Drive
300 mg tablet 30 tablets per HDPE bottle 36 months Store at 25degC Excursions to 15ndash
$100 per tablet
(WHO prequalified)
(FDA approved)
Foster City California 94404 USA
Tel +1-650-574-3000
30degC permitted $365 per patient per year
Fax +1-650-522-5870 E-mail ARVaccessgileadcom wwwgileadcom
Tenofovir
(FDA tentatively approved)
Matrix Laboratories Limited 1-1-1511 4th Floor Sai Ram Towers Alexander Road Secunderabad ndash 500 003
300 mg tablet 30 count CRC HDPE bottles 100 count non-CRC HDPE bottles Blister packs of 20s (2 x 10)
24 months Store below 39˚C $0546 per tablet
$199 per patient per year
Phone +91-40-27700363 +91-40-66327722
Fax +91-40-27700343
matrixmatrixlabsindiacom
World Health Organization recommended first line Adult Daily Dosage 300 mg daily Pediatric Daily Dosage The safety and effectiveness regimens using this ARV of tenofovir in pediatric patients has not been
establishedAdults
First line TDF + FTC or 3TC + EFV or NVP
Alternate first line TDF + 3TC or FTC + AZT or d4T
Second line TDF + PIr + ABC or 3TC (plusmn AZT)
PIr = ATVr FPVr IDVr LPVr SQVr
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 43
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
ZIDOVUDINE (ZDV) (AZT) NRTI
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Originator Product
Retrovirreg
(WHO prequalified)
(FDA approved)
GlaxoSmithKline Wellcome Foundation Dartford Kent
Tel +44 20 8990 9000 Fax +44 20 8990 4321 wwwgskcom
100 mg capsule 100 capsules per HDPE bottle
60 months Store at 15ndash25degC (59ndash 77degF)
Protect from moisture
$0122 per capsule
$89 per patient per year
250 mg capsule 40 capsules per blister pack 60 months Do not store above 30degC Store in the original package
$0276 per capsule
GlaxoSmithKline Ware Hertfordshire UK
300 mg tablet 60 tablets per HDPE bottle 60 months Store at 15ndash25degC (59ndash 77degF)
$0221 per tablet
$161 per patient per year
GlaxoSmithKline Catalytica Pharm Inc Greenville USA 5 Moore Drive PO Box 13398 Research Triangle Park NC 27709 USA Tel +1 888 825 5249
10 mgmL infusion 20 mL amber glass vial
10 vials per tray
36 months Store vials at 15ndash25degC (59ndash77degF)
Protect from light
$0032 per mL
$234 per person per year
GlaxoSmithKline Welcome Foundation Uxbridge Middlesex UK
GlaxoSmithKline 7333 Mississauga Road North Mississauga Ontario L5N 6L4 Canada Tel +1-905-819-3000
50 mg5 mL oral solution
240 mL amber glass bottle 24 months Store at 15ndash25degC (59ndash 77degF)
$0036 per mL
$223 per patient per year
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 44
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
continued ZIDOVUDINE (ZDV) (AZT)
Packaging amp Shipping Brand Name Manufacturer StrengthForm Information Shelf Life Storage Conditions Price
Generic Products
ZidondashH Hetero Drugs Ltd Genex Pharma
300 mg tablets 60 capsules per HDPE bottle Do not store above 30degC
$0150 per capsule
16671 Erragadda Hyderabadndash500 018 (AP) India Tel +91 40 2370 49232425 Fax +91 40 2370 4926 23714250
10 capsules per blister pack $110 per patient per year
wwwheterodrugscom wwwgenxpharmacom
Zidovirreg
(WHO prequalified)
Cipla Ltd Mumbai Central Mumbaindash400 008 India Tel +91 22 2308 2891 2309 5521 Fax +91 22 2307 0013
+91 22 2307 0393 wwwciplacom
100 mg capsules 1000 capsules per bottle
Shipping carton 10 bottles per inner carton
24 months Protect capsules from light and moisture
Store between 20ndash25˚C
$0075 per capsule
Zidovirreg (continued)
Cipla Ltd (continued)
300 mg tablets 10 tablets per blister strip 24 months Protect capsules from light and moisture
$0142 per tablet
60 tablets per bottle $104 per patient per year
(WHO prequalified)
Shipping carton 30 strips per inner carton 320 packs per shipping
Store between 15ndash25˚C
carton Dimensions 455 x 320 x 255 m Volume 037 m3
Weight 1685 kg
50 mg5 mL oral 100 mL PET bottle with 24 months Do not store above $0014 per mL solution syringe 30degC
$102 per patient per year
Zidovudina
(WHO
Combino Pharm Finaf 92 Barbara del Valles
100 mg capsule 100 capsules per aluminum strip
36 months Do not store above 30degC
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 45
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
continued ZIDOVUDINE (ZDV) (AZT)
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
prequalified) Medea SA Barcelona Spain wwwcombino-pharmes
250 mg capsule 40 or 300 capsules per PVCaluminum blister pack
36 months Do not store above 30degC
300 mg capsule 60 or 300 capsules per 36 months Do not store above $039 per capsule PVCaluminum blister pack 30degC
$285 per patient per year
50 mg5 mL oral 200 mL PET bottle plus 10 36 months Do not store above $0021 per mL solution mL syringe 30degC
$130 per patient per year
Zidovudine
(FDA approved)
Roxane Laboratories Inc Boehringer Ingelheim PO Box 16532 Columbus OH 43216 Tel +1 800 962 8364
300 mg tablets 60 tablets per bottleblister pack
10 bottles per inner carton
Store at 68ndash77degF
Fax +1 614 279 5517 wwwroxanecom
100 bottles per case
Zidovex
(WHO prequalified ndash tablet only)
(FDA approved)
Aurobindo Pharma Ltd Unit III Survey No 313 Bachupally Village Quthubullapur Mandal Hyderabad ndash 500 072 Andhra Pradesh India Tel +91 40 5572 5000 Fax +91 40 2374 1080 2374 6883 wwwaurobindocom
300 mg tablets 60 tablets per HDPE container
24 months Do not store above 25degC Store in original package
$016 per tablet
$117 per patient per year
50 mg5 mL oral solution
240 mL HDPE bottle
20 mL measuring cup
24 months Store below 25degC Keep bottle tightly closed
$0013 per mL
$95 per patient per year
100 mg capsule 100 HDPE container 24 months Do not store above 25degC
$0110 per capsule
LOGISTICS FACT SHEETS ARV DRUGS JULY 2008 46
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
Brand Name Manufacturer StrengthForm Packaging amp Shipping Information Shelf Life Storage Conditions Price
VirondashZ Ranbaxy Laboratories Ltd Dewas India
300 mg tablets 60 or 100 tablets per blister packs
24 months Do not store above 20ndash 25˚C
$01500 per tablet
(WHO prequalified)
(FDA approved)
19 Nehru Place New Delhindash10019 India Tel +91 11 26452666 72 Fax +91 11 26002076
60 tablets per blister pack
720 tablets per inner carton
$115 per patient per year
wwwranbaxycom 7200 tablets per shipping carton
Shipping carton Dimensions 049 x 036 x 023 m Volume 00406 m3
Weight 785 kg
World Health Organization recommended first line Adult Daily Dosage Pediatric Daily Dosage (according to GSK) regimens using this ARV Tablets 600 mg per day in divided dose in combination with Birth to 6 weeks 2 mgkg orally every 6 hours starting Adults other antiretroviral agents within 12 hours after birth and continuing through 6 First line AZT + 3TC or FTC + EFV or NVP weeks of age Alternate first line AZT + 3TC or FTC + TDF or ABC Infusion Infuse 1 mg over 1 hour Administer
dose 5 to 6 times daily (5 to 6 mgkg daily) 6 weeks to 12 yrs 160 mgm2 every 8 hours Children AZT + 3TC + NVP or EFV Do not exceed 200 mg for any individual dose
Price packaging and shipping information will vary according to contract specifications Source Meacutedecins Sans Frontiegraveres July 2007 Untangling the Web of Price Reductions Geneva Meacutedecins Sans Frontiegraveres
JULY 2008 LOGISTICS FACT SHEETS ARV DRUGS 47
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
For more information please visit deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom
USAID | DELIVER PROJECT John Snow Inc
1616 Fort Myer Drive 11th Floor
Arlington VA 22209 USA
Phone 703-528-7474
Fax 703-528-7480
Email deliver_projectjsicom
Internet deliverjsicom