54 x'rrat1rfi'a?rnryu,sf16{a{ N?,. ilii o ariui4 2 nrnglonr - frr+moru 2s39

{lo'i'g iirirt#rfi n H adr{ t 6 ss ua u n ?1 N rf;l ufi uJor

rfio{or n n'r :"(fisrtuuru a

:"rrfl #ooro{'

<, - < X q e d a I ^J^ X <t vrril ? r1l u6rsl? r n u{ [uLl']ua ntil914u.l ?111u il tn u.t HJllt? d't1t'luil1ttn? rrn vrtilnun! Ril1J ItJ 0

uyr:hur:rfifinr:fi'urrfioin:*rl:nrriur6urri'u Iourfiqro.rurdid'rfioin:crl:n turosa.rnr:tf :rrfi.:A Aq q e a q ai a A a t dvt:0.1fl?'r il n Liln1T t14 u'r il na 3 0't.1 0.J n1T ttill01n flu? tuq{ 01nil tu q fi a?1[ta']'t litj'] il n n:Jilrvt1,J

v 4 ev' I 4 e " rug1-?flo.iu'r nr:tilqrlLfidruttngtnfllaaufl1flo: 0u tqttn 1L?unlToo{lJU'ttlJ''}flT1.]n]u n'tTnT30'vaAa,to4rq

nrmuaanrorur :rrufr.:r5or1a.:Srryylrqai afruiuaiurorur"luirrnru"lnii'r6u.:n1umn (Macy, tooa) uoi

nffrlnyjrnr:t'i'ur:l.rrfio'Lurirurnn"rlrLnr:rfiqzuad'[rjfi,r:J::r.rdraioarorfiqfir*d" tt.: ,1 d'[rj*ur',nrtA at A q e A uq- a u < uv! a q q 4 a

14T0n?1ilr1lUf i1*tUflU1 rrJA [O:LU1tilOttn3il:il1iltOrJ1nU A{ tOrrililn?1ilfl1{!0 tunl:fln:91n.3€t11ilq

rflnfir.:larzunornnr:t'i'ur:rn'irrsriruuruu.u.n{udr:]a,fr'ltoiirfluerruqrTrirudrlri'rfionmruunnqir.:!iq , r i a q - X <a t alun1Tfl0LfluO.to0u1 tofJt:ilfln1j101R1100ult1{61unn0 fl?liltiflnn'I.Jn1.3fl:T?Ytu1 :314?'t.lfilt1Jttnyt!il')

a 'r I d ta r6ootuir.:nru 70 finfifiq:qiofiInnir.r rLru;fisritfivlu?11lTrJ1tu1A{tdao[uTl.in1ultil?iljjTilliltfl00tuTr.]nl u 70 ilJnnnqTn0ntnnTil 1r i'af-Araa,<rat:Jir:rrx go finfi6o:qianrfin:il "n.:tl:rJ'rilrnaqro.:ir.rnruriJuoi'l:-iluonn.rfl?'rrJttqnqr.illo.i€l?-rrJrllsJlJ1.[

t,qrL ol urfi o ri'luri n1flil1 unltiJuHnqionr:rrnin:rot ur a.:e,l-r ur rrqirJa,i'rfiorfi rJdnrr?nl rilylrrril urfifi{n l'r lr d'r rJ1:nlunr :fu n-rI:J :6 u'ld'n,r r vitfu ( aoorn e", I 9 9 0 )

% v Aa j o q v q ai:Jod ufrilnrrrueirrYryrurnfizi'rlri'rfienrr il uqn eir,r'[urio.:t atnr:t'i'ur:;n'ir.: qfir un;ur:fi60

jf adru'run.):rilqrt:-rfifi1 (Boothe, t989 ; Nash., tee+; ufnnlrra{ru'tilnltd6r nr:r:Jfiuu1:.Jro.l

q u eqv<t i rt.a N i I f !l , u I A XffiTfl:n1U tU t1ilUtfitljufl'tTvlnsnlU t9t tUUl r1r'tAvtQ3ljUA0nO1n:1.ln1U tnUilr{ [qao'til fr.ltlrunr:fruriroanriJu 2 szuz 6a

:;usfi t rflunr:rfiq?JU?unlroonE'[o"f i6rd'uialaTo:'[n6a(rrurfio, 2538) rfiolri'\qs

*.r*ro"'uri.r'loi6duuas'hoionr:rfiorJfrn3srrrorTrfi6ru1u::uyfi 2 qio'lil rr:fir.iru:su;d'[:Jud'r orofi

qnfin*n #tim ur un n oirt niutuuqinssfl6d ( Boothe", t9 9 o ) oro'[d'rr: qnlu'lad'fi'h o on qvrf,r.r3od U e t U sA <' Y v <u r e u u ,

L1{nTrU0'.l0 [otilq1t]J InflYlt]]uTtl*ulnn?1fl'tTn.:glun IGI 0u [9]ttn acetaminophen ttns phenyltoin

(Boothe", l99o) lu:rardlu,,urrruonqir,:ornfi'o{sil6ridu 1 6o nr:rfio deatkytation udr hydroxytation

^ t a q * c AL r v 6 ata(A v a1,o.tllL?unlroonfrtotu osrfreludq:rr5'rfrsirilrnniraojmijfrai6u .1 (nronson, t983) uqiorir.:'[:frorl' Xvi. o q ea A-

n?1il ttqnql'Ju tilYl'r !utnonnr9lusfi't1tltlflRo't.tYttrot{uql01]J1un1T1ao u'I0 analnT1.]n'l utJ'tntyiln:.JqJ

1.l111un1Ttu:zuY,n 2

t nrnisrrnftiilur nrx;#q?u?lrufl1flflf ruuriyrurd'urau$du 4ooo2

KKU. Vet. J. Vol. e No.z July - December lsge

J::u;fr 2 rflunr:rfi0uurunr:J-snauornqt'u lourflunr:T-rrulJO.Juruioer:

, u rlll'[*',i'.., n ry u r u:n nir: ar :I ru rn n n t ur o r fi n fi] e x r d u di , o' -Tr.t nr u flT-t.t1l u to u lL to u'L.rl fr tr EJ"Lunr ::? il ql r.r J-^[urrrunr:fifi60 riu'lrri UDp-gtucuronyt

transferase Iourirtlunr:fito.: glucuronic acid* A^&nr nnlfr ilrtr (potar group) I o.l urnioruqrlLlod?a.lui (!ilrfio, ZSsa) flrrtuqndrrro.:ulln-uflqr fiuufl0ilnn s lr:_Lir ulr l= rou'[rr]fr"[urjirLr ru

<uuol uToz'roriu'Lrrirfiofi (Macy,t 994 ; Nash,

r 9 a + ) d'.: riu6.: ri atdr fi o zu 0 n :: ?1 L qi o u.r fi ci'0.: rir uI ri r u n'r rlliu o o n o l n il.r nr r d.r dr r il u o*o.r e.i r ulJlr1unr: nnlnl:flror-u (glucuronidation) Ioltal,lr:trlunsiilta.l alcohols, phenols, aromatic

carboxylic acids, amines, amides ttn: thiols,

(Aronson, 1983 ; Bootheu, j 990) 6.:rfluarruqlqe .j -

q

Luutnnnr:_roon leu?Lrunr:firiluun-n i:nn,i',.-r r r"n r'' n ir.r nr llu fo :r fi n q n i,,r, f u *trl

A A^r er r n:.t I r at o,t u t'ludr.: n I u tr rj r ll r ul ud u(Bootha, 1990) ornnl:fin:gltal Wetchrunrnn{: dio'r.lleu Nash rLdrflru: ( 1 984) ilLjrrtlrall't:nfiot?6'e acetaminophen oonelnir,: nr uIo u riruru? unlrn nlol:luri'- Fro uo rner

lci'rfi u.: g ril o{rryuei-,d r,fi"uuiu *ri, d., *., u -.r ro

^ * u. - q

rnq0u'[6ia.:frJ 5O-60 rrjoirruoi u:J1unl:J. is

fl ouornq"i-ufr [quilrnil-nrfi onlr n:onnlnl:finu ii': fr.r or ru r r n r fi o fi'rl sr : d u fu'[ ai'rrri "l''n r d qr

nnor'lilau (cSH), acetyt group, methy group,

cysteine, nnTnsun;n:qo:fiIu'[oi' (Boothe",199o ; Macy, 1994 ; :.lqrfio, 2538) d{nr:rfict"i'a r :^l qr - n a u. rn e,d'u rilui fi vrr.r : o.rlunr :d'rr o.:

urniorrJqrlu'lndds.rrur:nrfi odutuulr srirrta:ou lrilun1Ti':Jri'lnnlqrT:'luai' (Nash, rs 8+ ;

Aronson A.L., lg83 : Macy, 1994 ; Boothe", l99O)si.r n rn t rrsifi r,r u'ir ril? un1.rd'a ril n n a un rn qf.uriu r fi e nr:a ru or-r o rir.: :r o rT.: rjirur nr"ur u6o

T u rArilqr [L'Lnd'fi or n nriu o anarnir.l nr ulo uru?uXa o Jt"-nr:: or fr6.r r fr ofi uloilu:Jirur ruo'r rio Ie u ro1^,r.r:

nr : r fi srs-n ril n o o uo r n e fu n-u u rlun ei rurL o.r

phenolic triu dipyrone (St. Omer, t983Boothec, 1 990) uonornduJrnr:rrJfi uuifrlo.l1 u ? unr :r rr orlu ff 6 I fi r ff o du o I o virili'ldsr:oi'r n nr.r fi ri 01fir ff o nrr u ril un' udu

55

tt1{acetaminophen st-rnnr.:firiJufirc6o N-acetyt

para-benzoquinone immine (NApOl)(xolr-Ctauw, 1 994) qi.:riu rfio?Lrunr:rfied'c n l o rr ouo rn e,r rfi o nr:6 r rfi-r'ld'ir u6 r rfl uru n zu n

t a r nr :tr.i'd'n r il q o r n n r u u o n rdr aiir r n r u To r n r :tf N-acetytcysteine rfi arfluuriuifi u (antidote)

(Nash, 1984 ; Kolf-Clauw, 1994 , St. Omer,

1983 ; Boothec, 1990) urnr-,nd,irfirEulrfa <, ;- Joglutathione (cSH) qr.lrilunr:fr air,:fru"[uir.:nru

firi': ulunr:ro''o ar:fiurl-r nc r.:firfieduluir,:nr r! ^a Atfrolornifrrt:o.r6u 1 Ieu csH fiurirfirilu

antioxidantlurfiordaorre.Jrun:rfl u reducing agenr;- A -yrqu rfro GSH a'lril NApei o:rirtrinnrrlfrlutflu cysteine acetaminophen conjugate LLf,:

mercapturic acid conjugate riounnrilaanyrr.:rJaarrlqia'hj (Nash, t984 ; St. Omer, 1983 :

Kulata, 1 981 ) rfluzuntri:yo'u?o{ cSH fioi'l*nyt fi el 16 a o uo.r n o a J o d-r.i : l o i;-l d.: r fi o : : olu r a.r

u ri-r a u Luri yl EtlJ d q n n il-l n ni1 7 o _ B o % I o.l :: qil il n 6

o : ri a lr.i'r fi o n 1 :r? l o--t lJ o.i r er q r I L'l n dfi r fl ufi :gn::t

n ucleoph ilic ? 0.t Ird 6i-sl-rJ yir lvirr n d et-L or u

( necrosis) rrn ; ri,r ni1firfi q methemoglobi nemia

st'lltrJ1 (xott-ctauw, t994 ; Nash, t984)ua nar nr ! ? un1 rn nln]:fi ro d'uu#.1

lJ lJ ? iln I r acety tatio n r fl uri :.i -: un r :fi 1 il r fi olu nu"l

u n : r il ? r fl una qtli'r fi o r{ R'l il fi .t il r: fl o,i"lu n r rfl o r.,,1

u r fi o c d'o.r i.i'r u? r.J ? u n 1 : dt u n r : rili'o o o n a r nir.:nru Teuil!nr:rfi orluururrurnn.irnrir rriuprocaine (Boothe" D.M., t990)

I

56 ?1ra{1r#n?rryrilscl'16{o{ Nfl. fl{4 o arlud 2 nrnglcrru - fi'umnru 2539

q u Aa:lo o'uff fi nrrt eir n"'ru fuo-l ear:ororn

f aa A ,

1Jr.J'run1t[ila1 t! d"trrl do uin ri',orruir.: utrnr.rveacalufl1l?ttd? u.11tu?1 ttSJ?3JIuota0qtto.3m t?aa

L <, q tan1:Ino00nslot1l tlJ1.[ilnLutnofln']?3

methemoglobinemia'[oi'irun'jr nu ]i't udrfl1f1lI

(Boothe", 1990 ; Nash, 1984) finr:0r".:atr:6grua A oqrsn.:artuofryirLl{rnqrdoo$o.: (hemoglobin) la.:rirurfi omer'[r qi o anlrcai.] ndm fi 6 o

dc u d1. tJtoillqtil methemoglobin reductaseqdcaqer'"a[utsantruotn091tto.J [un?1ilt1JillJuq1UT0d, I jil:J:;Rvrinrnqir fi.rrou'[rf methemogtobin

reductase drrilueionr:r:jduu methemogtobin

nfu'[r]riJu hemoglobin o-r16r: (Aronson, t983)

ri'r:rj za

2. Tn:.rafrt hemoglobin uo,i felinec^A

uonei"r.ri1nfl=elitfro5u6o orfi sut{hydryt group

s,rfir 20 nril (eootfre", t99O) uqiornnr:dr.:ro.:

Nash rnsflrus (1984) rn! Weiss D.J. (t990)And-:.llon'jr uilrfi sul{hydryl groups odr.:riou

A - < ^ A a , Aaau nnil s.Jillnn?lflqltuooun.l 2 [y]'l fl.]sJtnu.t,ya+ najlrrirriu 6.1 Sutfhydryt group o;hJria

f AAA t * 4 T u d r,lJfl nTmnLq? u'to.t9tuv1r0 rilq1 tu [as tet j] u

3" nlrr'tqr5iltrf gtutathione dotfU

I cA , < a f u <AnluLurqtnfls.tt?urn!nu tilql tu td{6.tri.lfl3flil'.1 ' oqea la- - Y

a u tuT1.t n1 u 01oyl1 tu tno! fl nTUr ql il il1'L9t 9l.tuui<urn'r?rfir1orAu"[rf glutathinone 6rifluzuntr.i'

sullhygryt group turfio16oouo.lrfioaonEIof'uq r u cT s, .{nLtilfll tu tns Io.1'tulJ1{ t:']ilny{Lffn11c

meth emog lobi nmia rfi o.: or n ntTld' acetam i nophen.l Ue, 6l A e .i[ut$J? LoLau lilfln"I?; methemoglobin fr,:tunntrct d, Z'

tiluo.l ri:J::n olriuov o dtu:lr o.l ryla3q ( Fe.')

Irvtu:iltln6 6a ferrous (Fe.'?) yiltd'lilarrur:ndr

o o nfi rou'l:J u-.r rdo rfi o eirusirr .1 r ordr r nr u'[oi'<tqed

t:lut{n tfi il0'tn1T hypoxia, Cyanosis

flnlli10{ methemoglobinemia fl'}ulTne a d Yl 9 T dd I Ifl.trnn01nfi1j0{tn0q to [ouasilfltto.]t{ilauri,1Yaf<Ta

illn1dT0n [nttnq tquflo3[t:1Tfluq1ilil5il1iln17

tfio methemoglobinemia3 uq A a t < <t ail0n0'tnilun? til[T0.ift{l^lto0i [!uan

q - ) o o ra

rlo,il'ufivir'tri'rfio nrrru unnqir.llunr:q oL fiuo{ qio

nr:t'f'ur:rui1.t {1f1J rtnruill rliu morphine d.lorj

vrilli'u r r fi nr : o a ! fl il a.J'[ur 1 { q r.J li1 et n-L arit 6 oto q ea A - - X

vir'lri'rfi qnrr :6uroi'u nrs'] unrri't u rn 1u'lei'AA.;t.lt50lltnU?10.lnLJ dopaminergic receptor

(Macy D.W., 1994 ; Aronson A.L. et al., t983)

ilonornflod'uai1.r,1 rurirdfi ororylhtd'^ e d <r a A q-

tn q zu n1 1.t to u,l u n t n 11 tJ lil l+y't 19[u a.J 01 n nl : [T u.ty Y ; j* , d, j"q--

ltd? l.tu fl.t 11 ;.Jnasfl L?'t 3J fl -] 1{?1 ?11 tfi tn q n 11 ilX d qe q ! ^!uu:llJ1nfiu fi o nr:lrfur-lurlieLrrxff tinrfi il'llj

f;d,a-Yto u tflll'13til a tr uLil:il'lilu1n:Jil'tuunl on ttil']Y' X ! !a. <, Aq -vr.lu tu0{alnu1?1il0"1141{'tuilnorrililu1m Llt

a a A - a'o q id1fi :unuu:odul, s.l ilnil!Til1 ilU't tUlJ U't 0r illnI4 o6le q ut0.1 Yr1 til [ n q fl ?'t 3J T1{ ttT{ ql a n 1 : I n o v\l 1' Lu tt ru r

-[ c{

9

ir rn'ir

oxldlzlng agent

Methemoglobln Reductase

KKU. Vet. J. Vol. 6 No.2 July - December 1ee6

Aronson A.L., Riviere J.E. 1983. Toxicology and pharmacology Feline Medicine edit by Paul W.

Pratt. American Veterinary Publication USA. 61-83.Boothe D.M. 1990. Drug therapy in cats:Mechanisms and avoidance of adverse drug reactions.

JAVMA. te6(8) . 12e7 - 1 30s (a)

Boothe D.M. 1990. Drug therapy in cats:A therapeutic category approach. JAVMA. 196(10) :

t6se-t66e. (b)

Kolf-Clauw-M., Keck-G. 1994. Paracetamol porsoning in dogs and cats European-Journal

of Companion Animal Practice. +(Z) : 85-92.Kujala C. and Randall J.W. 1981. latrogenic acetaminophen poisoning. Feline practice. 11(5) :

12-14.

Macy D.$/. 1994. Pharmacologic considerations in the cat. Feline Practi ce. 22(Z)Mckellar Q.A., May s.A. and Lees p. 1991 . pharmacology and therapeutics

anti-inflammatory drugs in the dog and cat: (2). Journal of small Animal

225-235Nash S.L., Oehme F.W. 1984. A review of Acetaminophen's effect on Methemoglobin, Glutathione

and some related enzymes. Vet. Hum Toxicol. 26(2) . 123-132.Norsworthy G.D. 1993. Drug peculiarities. Feline Practice:Philadelphia:Lippincott. XVl,6gg p.

St- Omer V.E.V. 1983. Treatment of acetaminophen toxicosis in cats. Modern Vet. practice 815-g'1 B.

57

. 14-18.

of non -steroidal

Practrce. 32 .