Lombardi Comprehensive

Cancer Center

Cancer Informatics Summit

2/21/2013

Subha Madhavan, Ph.D. Director, Innovation Center for Biomedical Informatics

Georgetown University Medical Center

Director, Clinical Research Informatics

Lombardi Comprehensive Cancer Center

Vincent T. Lombardi

• Famous professional

football coach

• Fell ill at Washington

Redskins’ practice on

Georgetown

University field

• Treated for cancer at

Georgetown

• Cancer Center

named in his honor

“Winning isn’t everything, it’s

the only thing.”

Lombardi – At a glance

• Established in 1970

• In 1974, Georgetown Lombardi became the 16th

NCI-designated Comprehensive Cancer Center

• Over $100M in research funding ever year

– $35M CCSG + peer-reviewed funding base

• 94 full members; 186 cancer-connected faculty

members

• 4 Research programs & 9 Shared resources

• 220 ongoing trials

Key Accomplishments

• Development of human papillomavirus (HPV) vaccine to prevent cervical cancer – R. Schlegel

• Discovery of GADD-4 DNA repair gene – A. Fornace

• Nuclear hormone receptor networks in breast cancer – R. Clarke

• Monoclonal antibody therapy – L. Weiner

General Organizational Structure

Director (Weiner)

Clinical Care (Marshall)

Clinical Research (Giaccone)

Population Sciences

(Mandelblatt)

Basic Research (Wellstein)

Minority Health (Campbell)

Shared Resources

(Byers)

Administration (VanderHoek)

Deputy Director (Atkins)

Another view of the cancer center

AD Minority

Health

AD Shared

Resources

AD

Administration

Network

Representative

AD

Population

AD Clinical

AD

Basic/Transl

Deputy Dir

Director EAC IAC

BC ET

MO CPC

Sh

are

d R

eso

urc

es

Trial Oversight

Ad

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istr

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n

Research Education

Community

Advisory Council

Informatics @ Georgetown

Innovation Center for Biomedical Informatics (ICBI) http://icbi.georgetown.edu/

• Faculty – 5

• Senior staff members – 5

• Research associates – 5

• Support staff – 2

• Consultants – 5

• Students/Trainees - 2

Expertise in bioinformatics, clinical informatics, biomathematics,

biostatistics, clinical genomics, molecular biology, high-throughput

molecular assays, enterprise class software development, data

management, data security, & project management

Informatics Org Chart

CTSA PI CCSG SR Director

Dean of Research

ICBI Director

Highthroughput

omics

Technology

Development

Health IT ChemiInformatics Data Coordination & Biocuration

Clinical Research

Informatics

Director, Operations Financial Analyst

Office Manager

Communications/

Scientific writing

Cancer Center Director

FTEs supporting Cancer Center – 8

Total FTEs - 22

Informatics Funding

$3.5M Total Annual Funding in 2012

Lombardi Information Architecture

(current & future)

Integrated Data Environment:

G-DOC Links to Many of Data Silos

G-DOC

Pathway Studio

•Systems biology

•Literature

Ingenuity Analysis

•Pathways, GO, Variants

RedCap

Clinical Research

EHR’s

JMol/Marvin

• Molecule Visualization

Cytoscape

•Visualization networks

JBrowse

•Genome Visualization

Disease Classification

Tools

https://gdoc.georgetown.edu

Over 330 registered

users from six countries

~250 unique hits/month

Making Patients Part of Healthcare Through

Technology Innovations

Amazon S3

Bucket

Genomic Data

De-identified Clinical data

Amazon EC2

Compute

Instances

Amazon

Glacier Vault

MongoDB EC2

Instances

Genome Data

Oracle RDS

Instance

Clinical Data

G-DOC Web

Portal

User PC

Next Generation Sequencing

Big Data Analytics on the Cloud

Clinical Research

Biospecimen Basic/Traslational

Clinical Education • Informatics

education

• Partnerships

• Joint grants

• Joint appointments

• Contracted services

• Shared resources

• Medical internships

• Shared IP

• Joint publications

Informatics for

Discovery, Clinical Research, Clinical Care

• ‘omics’ data analysis

• EHR/PHR integration

• Biomarker discovery

• Disease

classification

• Genotype-Phenotype

correlation

• Biospecimen

management and

analysis

• Technology/method

development

Website : https://icbi.georgetown.edu Email : icbi@georgetown.edu

Challenges & Opportunities

Major Challenges:

Diverse set of policies and regulations across

participating institutions

Lack of resources (human and IT)

Multiple clinical & research information silo’es

Significant Opportunities/Strengths:

Technology development

Community engagement

Test bed for innovation

‘omics’ methods & integration

Collaborations with CTSA