long term health effects of humans exposed to pcbs … · serum level = dioxin toxic equivalency...
TRANSCRIPT
![Page 1: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/1.jpg)
LONG TERM HEALTH EFFECTS OF HUMANS
EXPOSED TO PCBS AND PCDFS
Y. Leon Guo, Environ & Occup Med
Judith Shiao, Dept of Nursing
National Taiwan Univ. (NTU) and NTU Hospital
Taipei, Taiwan
29/10/2011, Carpi
![Page 2: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/2.jpg)
![Page 3: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/3.jpg)
1897 Taipei
Hospital
1899 Taiwan
Governor Medical School Environmental and
Occupational Medicine National Taiwan University Hospital, 1990
![Page 4: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/4.jpg)
Univ. of Bologna
![Page 5: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/5.jpg)
Bologna, Italy
LuKang, Taiwan
1979 Yucheng
![Page 6: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/6.jpg)
TaiChung County ChangHua County
(Guo et al., JTEH 1994)
Yucheng (oil-disease) episode
Outbreak in 1979 Acne-form skin eruption,
pigmentation of the skin and nail, hypersecretions of the Meibomiam glands of the eyes Approximately 2000
victims involved
![Page 7: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/7.jpg)
Likely Kanechlor 500 (a Japanese PCB mixture)
Piped in heat-medium to deodor the rice oil at a final stage of production. Leakage of the heat medium caused contamination in oil, and intoxication in people
Yusho, Japan, 1968
![Page 8: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/8.jpg)
Life-time exposure
0
1000
2000
3000
20 27 34 41 48 55 62 69
Yucheng
Population
WHO safe level
age
Seru
m le
vel
Serum level = dioxin toxic equivalency (TEQ)
![Page 9: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/9.jpg)
Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham, US CDC (ISEE 2004, New York)
![Page 10: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/10.jpg)
Dioxin: Multiplicity of Toxicity • Carcinogenicity • Immunotoxicity • Dermatological Toxicity • Hepatotoxicity • Neurotoxicity • Reproductive and
Developmental Toxicity • Effects on endocrine system
How about health
consequences in humans?
![Page 11: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/11.jpg)
Mortality by 24 year follow-up (Standardized mortality ratio, compared to national
death certificates) • 1980-87: Increased chronic liver diseases and
cirrhosis, SMR= 3.7 (95%CI 1.6 – 7.2, 8 deaths) • 1988-1995: Increased systemic lupus
erythematosus, SMR=19.8 (95%CI 2.2-71.3, 2 deaths)
• 1996-2003: Increased systemic lupus erythematosus, SMR=18.9 (95%CI 3.8-55.2, 3 deaths), increased TB, SMR=3.6 (95%CI 1.0-9.1, 4 deaths)
(Yu et al., AJIM 1997; Tsai et al., STE 2007)
![Page 12: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/12.jpg)
Yr of death
Age at death
PCB level (ppb) /yr measured Work Causes of
Death
1989 27 61/1985 None SLE Pneumonia
1994 33 15/1981 Housewife SLE
pneumonia Septicemia
1996 39 162/1980 None SLE
septicemia brain edema
1997 40 92/1980 Farmer SLE
1999 44 75/1982 Manufacture umbrella
SLE
All SLE subjects were females. Age at exposure: 17, 18, 22, 22, 24 Background PCB level: 1.7 ppb. (Tsai et al., STE 2007)
![Page 13: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/13.jpg)
Yucheng morbidity vs. controls Chloracne 16x Hyperkeratosis 7x Abnormal nails 8x Skin allergy 2.4x Gum pigmentation 7x Broken tooth 2x Goiter 3x Liver disease 2.4x
Women Anemia 2.3x Stillbirth of baby 2x
Men
Spine problems 3x Arthritis 4x
(Guo et al., EHP 1999) DM, HTN, CAD: not different
![Page 14: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/14.jpg)
![Page 15: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/15.jpg)
Reported diseases ever diagnosed as of 2003 (24 yr later, age 62), in women
Yucheng (n=332)
Reference (n=332)
AOR* (95% CI)
Type 2 DM 11.3 5.6 2.1 (1.1-4.5)
On therapy 7.7 3.2 2.5 (1.0-6.5)
Hypertension 18.5 14.4 1.3 (0.8-2.2)
Cardiovascular Diseases 10.6 8.6 1.4
(0.8-2.5) *Adjusted for age, BMI, smoking, and alcohol use
(Wang et al., Diabetes Care 2008)
![Page 16: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/16.jpg)
Reported diseases ever diagnosed as of 2003, by chloracne, in Yucheng women
Chloracne --
(n=186) +
(n=58)
AOR* (95% CI) Type 2 DM 5.9% 24.1% 5.5 (2.3-13.4) Hypertension 14.4% 37.9% 3.5 (1.7-7.2) Cardiovascular
Diseases 11.8% 25.9% 3.0 (1.5-8.6)
Serum PCB (ppb) 73 121
*Adjusted for age, BMI, smoking, and alcohol use (Wang et al., Diabetes Care 2008)
![Page 17: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/17.jpg)
Neurocognitive functioning • Yucheng and control people aged 60 or
above • Neuropsychological test battery
– Mini-mental state examination (MMSE) – Wechsler’s Adult Intelligence Scale (digit span
and digital symbol) – Wechsler’s Memory Scale-Revised (WMS-R) – Geriatric Depression Scale, Short-form (GDS-S) – Bathel’s index of Activities of Daily Living
(ADL) – Motor skill and tactile performance
![Page 18: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/18.jpg)
1 2 3
4
5
6
7 8
Visual Memory Span (VMS)
![Page 19: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/19.jpg)
Neurocognitive testing in women
Group
Controls (N=162)
≦30ppb (N=42)
30-90ppb (N=63)
≧90ppb (N=43)
VMR (p<0.05, test for trend)
29.1 ± 7.5 26.8 ± 7.3
26.5 ± 6.9 26.1 ± 8.6
VMS (p<0.05, test for trend)
10.8 ± 2.9 10.0 ± 2.5 9.7 ± 2.7 9.6 ± 3.2
Test
*Adjusted for age, sex, and education
4.8 yrs 5.4 yrs 6.3 yrs
3.6 yrs 5.0 yrs 5.5 yrs
VMR: -0.48/yr of age, adjusted for education
VMS: -0.22/yr of age, adjusted for education
(Lin et al., EHP 2008)
![Page 20: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/20.jpg)
Menstrual cycle length among Yucheng women and their neighborhood referents Adjusted for age at interview, BMI, smoking, alcohol, and
marital status by multiple regression analysis
(Yang et al., Env Res 2011)
![Page 21: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/21.jpg)
Yucheng women fertility Average age of exposure: 15 yr
(Yang et al., EHP 2008)
Fecundability ratio = 0.9 (95% CI 0.8-1.0)
![Page 22: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/22.jpg)
Dr. Walter Rogan - NIEHS, USA
How about 2nd generation?
(Rogan et al., Science, 1988)
![Page 23: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/23.jpg)
Cognitive Development
80
100
120
BayleyMDI- Age2
BayleyPDI- Age2
SB IQ-Age4
SB IQ-Age5
WISC IQ-Age6
WISC IQ-Age7
Yucheng Control
(Yu et al., 1991, Chen, Guo, et al., JAMA 1992)
Matched for gender, age, mother age, residence, SES
Prof. CC Hsu
![Page 24: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/24.jpg)
Tooth problems
![Page 25: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/25.jpg)
Tooth defects (%) according to PCB level at pregnancy
(%) Neonatal teeth
Fusion
Microdontia
Peg tooth
(Wang et al., Env Res 2003) Yucheng
![Page 26: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/26.jpg)
Otitis media
• Between 8-14 years of age, the Yucheng children had 10x otitis media compared to neighbors
(Chao et al., AECT 1997)
![Page 27: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/27.jpg)
4446485052545658
7 8 9 10 11 12 13 14 15 16
YuchengControl
A�g�e� �
C�
B�C
�L�
�s�c�o�r�e� �C�h�i �l �d� �B�e�h�a�v�i �o�r� �C�h�e�c�k�l�i�s�t� � �
(�C�B�C�L�)� �s�c�o�r�e�s� �
(�* �A�d�j �u�s�t�e�d� �f �o�r� �s�e�x�, � �y�e�a�r � �o�f � �b�i�r�t�h� �a�n�d� �y�e�a�r� �o�f� �a�s�s�e�s�s�m�e�n�t�)� � �(�L�a�i� �e�t� �a�l�.�,� �Arch General Psychiat,� �2�0�0�2�)� �
![Page 28: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/28.jpg)
• Yucheng children had more problems especially on Somatic complaints, Attention problems, Delinquent behavior, Aggressive behavior, Introversion, and Extroversion
• Yucheng and control children scored similarly in Withdrawn, Anxiety/Depressed Mood, Social problems, and Thought problems
![Page 29: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/29.jpg)
Semen Analysis Yucheng 12 young men (16-20 yr old)
compared with 23 controls
Volume and count: no difference Morphology: 38% vs. 26% abnormal (~50% increase) Motile sperm: 35% vs. 57% (40% drop) Speed by CASA: reduced velocity by 20% in motile sperm Chinese hamster oocyte penetration: 66% vs. 75% (12% drop)
(Guo et al., Lancet 2000)
Science News 2000;158:303
Semen lab in Lukang
![Page 30: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/30.jpg)
*Measured by “Blinded” physicians
Penis length (cm)* in Yucheng and Control Boys by Age
6 to 7 8 to 9 10 to 11 12 to 13 14 to 150123456789
6 to 7 8 to 9 10 to 11 12 to 13 14 to 15
Yucheng Controls
** *
***
![Page 31: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/31.jpg)
Serum hormonal levels in Yucheng and unexposed boys, age 12 yr
Yucheng (n=17)
Unexposed (n=15)
p- value
Testosterone (ng/ml) 3.0 ± 2.4 4.2 ± 2.2
Estradiol (pg/ml) 48.6 ± 53.9 21.3 ± 13.2 * Testosterone/ estradiol
0.3 ± 0.2 0.5 ± 0.2 *
(Hsu et al., JTEH 2005)
![Page 32: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/32.jpg)
Lake Apopka Aligators, Florida, USA
• reduced fertility • smaller-than-
normal penises • Female dominance
in sex • exposed to runoff
of pesticides, mainly DDE
Professor Louis J. Guilette
![Page 33: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/33.jpg)
Future studies 1st generation •Health-related quality of life •Mortality and morbidity due to cancer and chronic diseases •Early changes potentially leading to SLE 2nd generation •Mechanisms behind semen quality change •Epigenetic changes Both •Mechanisms behind neurocognitive changes
![Page 34: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/34.jpg)
National Taiwan U., Taiwan – Liang-In Lin, Eric Tsuang,
Motion Tsai, JD Wang
National Cheng Kung U. – Wen-Yuan Chao, Yung-Jung
Chen, Yung-Cheng Chen, Pau-Lin Guo, Mark ML Hsu, Te-Jen Lai, Wei-Jen Yao, Mei-Lin Yu
National Health Research Institute, Taiwan
– Shu-Li Wang, Louis Chang
National Kaohsiung First U. Science Technology, Taiwan
– Ping-Chi Hsu
Acknowledgment National Institute for
Environmental Health Sciences, USA ‒ Walter J. Rogan
UMDNJ - Robert Wood Johnson Medical College ‒ George H. Lambert
US CDC ̶ Larry Needham
Food Safety, Canada ‒ John Jake Ryan
Japan ‒ Masuda, Ikeda, Yoshimura,
Furue, Iida
![Page 35: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/35.jpg)
Grazie!
![Page 36: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/36.jpg)
Proportion of male births ofYucheng Fathers, 1980-1999
0.3
0.4
0.5
0.6
0.7
1980 1985 1990 1995Year of Birth
%
UnexposedExposed
(�d�e�l� �R�i�o�-�G�o �m�e�z�,� �G�u�o�, � �e�t� �a�l�.�,� �L�a�n�c�e�t� �2�0�0�2�)� �
![Page 37: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/37.jpg)
Duration of Breast Feeding (weeks) and Mothers’ Serum 2,3,4,7,8-PnCDF Levels
(Guo et al., AECT 1997)
0
500
1000
1500
2000
2500
3000
3500
0 20 40 60 80 100
![Page 38: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/38.jpg)
Estimated 1,2,3,4,7,8-HxCDF at 1 year of age by duration of breast-feeding
y = 40.82x + 289.05
0
500
1000
1500
2000
2500
3000
3500
0 10 20 30 40 50 60
weeks of breast feefing
Hx C
DF
(ppt)
(Ryan et al., Chemosphere 1994)
![Page 39: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/39.jpg)
(Hsu et al., Br J Dermatol 1995)
![Page 40: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/40.jpg)
0
200
400
600
800
1000
1200
0 100 200 300 400
1992年血中濃度,美國CDC協助檢測
PCB (ppb)
PCDF毒
性當
量
![Page 41: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/41.jpg)
0
200
400
0 5 10 15 20
1992年血中濃度,美國CDC協助檢測
PCB (ppb)
PCDF毒
性當
量
![Page 42: LONG TERM HEALTH EFFECTS OF HUMANS EXPOSED TO PCBS … · Serum level = dioxin toxic equivalency (TEQ) Dr. Patterson, US CDC Professor Lambert, UMDNJ (Dioxin99, Venice) Dr. Needham,](https://reader034.vdocuments.net/reader034/viewer/2022050312/5f73eb511677fd4cfc783842/html5/thumbnails/42.jpg)
After the Yucheng intoxication • No effective therapy, long half lives of
internal exposure • ↑ mortality due to chronic liver diseases early
after exposure, and SLE later • ↑ goiter, chloracne, headache, peripheral
neuropathy • Men: ↑ arthritis & spine problems, ↓ semen
quality • Women: ↑ DM, CVD (?), anemia, and stillbirth,
↓ fecundability