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J Sex Med 2007;4(suppl 1):63

Lower Urinary Tract Symptoms and Erectile Dysfunction:

Emerging ConceptsSATURDAY, NOVEMBER 4, 2006

THE WESTIN CASUARINA HOTEL • ACACIA C-D • LAS VEGAS, NEVADA

12:30 PM – 12:45 PM .................Lunch and Registration12:45 PM – 12:50 PM .................Welcome and Introduction

John Mulhall, MD, ChairAssociate ProfessorDepartment of UrologyDirector of the Sexual Medicine ProgramWeill Medical College of Cornell UniversityDepartment of UrologyDirector of the Sexual Medicine ProgramMemorial Sloan-Kettering Cancer CenterNew York, New York

12:50 PM – 1:10 PM ...................Prevalence and Impact of Lower Urinary Tract Symptoms Michael O'Leary, MD, MPHAssociate Professor of Surgery Harvard Medical School Senior Surgeon, Division of UrologyBrigham and Women’s HospitalBoston, Massachusetts

1:10 PM – 1:30 PM ....................The Scientific Basis for a Link Between Lower Urinary Tract Symptoms and Erectile DysfunctionJohn Mulhall, MD

1:30 PM – 1:50 PM ....................Lower Urinary Tract Symptoms and PDE5 Inhibitors: The Shifting of a Paradigm Culley C. Carson, MD, FACSRhodes Distinguished ProfessorChief of UrologyUniversity of North CarolinaChapel Hill, North Carolina

1:50 PM – 2:10 PM ....................Panel Discussion — Question-and-Answer Session2:10 PM – 2:15 PM ....................Closing Remarks

John Mulhall, MD, Chair

Program DescriptionLower urinary tract symptoms (LUTS) occur secondary to dysfunction of bladder storage or emptying. LUTS commonly correspond with benign prostatic hyperplasia(BPH) because of bladder outlet obstruction. Investigation of the association between BPH and health-related quality of life (HRQoL) assessed by validated question-naires in randomly selected men has revealed that disease-specific HRQoL was worse in older men. In this study, age-adjusted mean scores for symptom severity,bother, and activity interference were approximately 50% worse for men with enlarged prostates. Men with enlarged prostates were nearly 3 times as likely to havemoderate to severe symptoms and twice as likely to have bother or activity interference compared with men with smaller prostates.

The presence of LUTS associated with BPH has been identified as an independent risk factor for development of erectile dysfunction (ED). It is hypothesized that acommon pathophysiologic mechanism, such as decreased HRQoL and/or increased pelvic α-adrenergic tone in association with bladder outlet obstruction, may causethe occurrence of both LUTS and ED such that the 2 disease processes coincide as men age. However, the exact link is not yet fully defined. Emerging data high-light the potential role for PDE5 inhibitors in men with LUTS.

Target Audience This activity has been designed for urologists and healthcare professionals involved in the care of patients with urinary tract symptoms and erectile dysfunction.

Learning Objectives Upon completion of the educational activity, participants will be able to

• Explain the importance of lower urinary tract symptoms (LUTS) and their impact on men's health• Summarize the clinical and basic science data linking LUTS and erectile dysfunction • Describe the emerging literature on PDE5 inhibition and its effect on LUTS treatment

AccreditationThe Academy for Healthcare Education, Inc., is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA PRA Category1 CreditsTM

The Academy for Healthcare Education, Inc., designates this educational activity for a maximum of 1.5 AMA PRA Category 1 CreditsTM. Physicians should only claimcredit commensurate with the extent of their participation in the activity.

This activity is supported by an unrestricted educational grant from Pfizer Inc.

This continuing educational activity is provided by theAcademy for Healthcare Education, Inc.A CADEMY FOR

H E A LT H C A R EE D U C A T I O N