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iCeMS 1 / 5 Hes7 1 Lunatic fringe Hes7 PI ( ) Hes7 Hes7 Hes7 1 Hes7 Achilles Hes7 Lunatic fringe 2020 1 8 1 9 3 Nature

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iCeMS 1 / 5

Hes7 1

Lunatic fringe Hes7

(

)

Hes7

Achilles

Hes7

Lunatic fringe

2020 1 8 1 9 3

Nature

iCeMS 2 / 5

(Presomitic mesoderm: PSM)

2 3 5

Hes7 ( ) PSM

iCeMS 3 / 5

Hes7

PSM

PSM Hes7

Notch

Notch Lunatic fringe Lfng

Hes7

Lfng Hes7

Hes7 Lfng

Hes7

(1) Hes7

PSM

Hes7

Venus Achilles

PSM Achilles Hes7

Hes7

iCeMS 4 / 5

(2) Lfng

Lfng PSM Hes7

Lfng PSM

Hes7

Notch

Lfng

(3) Lfng

Lfng

Lfng PSM 1:20

Lfng 1/8

Lfng

20:1 Lfng

Lfng

Hes7

Notch /

Lfng Notch

Dll1

Lfng

Lfng Notch

Hes7

(4)

Lfng

ES PSM

Wnt

KY02111 Lfng

Hes7

iCeMS 5 / 5

Lfng PSM Notch

Lfng

JST CREST

Brain/MINDS

Coupling delay controls synchronized oscillation in the segmentation clock

( )

Kumiko Yoshioka-Kobayashi, Marina Matsumiya, Yusuke Niino, Akihiro Isomura, Hiroshi

Kori, Atsushi Miyawaki, and Ryoichiro Kageyama

Nature DOI: 10.1038/s41586-019-1882-z

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Supplemental Informationgenesdev.cshlp.org/content/suppl/2011/05/31/25.11... · 5/31/2011 · Hes7. Note that segmentation (arrow) occurred between 3 and 4 when the Hes7 expression

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Ultradian oscillations of Stat, Smad, and Hes1 expression ... · Hes7 and its target gene lunatic fringe (Lfng) also display cyclic expression and regulate periodic somite segmentation

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Dynamic Expression of lunatic fringe Suggests a …100 years ago, the mechanism(s) underlying somite formation remain poorly understood. Recently, however, several genes Recently,

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Storage on the Lunatic Fringe - DTC · ¥ Support for very large (multi-petabyte) file systems ¥ Single files of multi-terabyte size must be permitted. ¥ Scalable file creation

Title Oscillatory links of Fgf signaling and Hes7 in the … · 2016. 10. 14. · Hes7 drives coupled oscillations in Fgf and Notch signaling, which inhibits and activates Mesp2 expression,

di - jfk.hood.edujfk.hood.edu/Collection/Weisberg Subject Index... · except the ravings of the lunatic fringe. I can't help or eliminate thet. If you had done as 1 asked it might

Computing on the Lunatic Fringe - University of Texas at ... · The power problem 1 10 100 1000 10000 100000 1000000 Power ... –Getting close to optimal efficiency 17 PFLOP/s 18,688

Serving Data to the Lunatic Fringe The Evolution of HPC Storage …pages.cs.wisc.edu/~johnbent/Pubs/bent_login16.pdf · 2016-06-29 · Storage, I/O, and Data Management National Co-Coordinator

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1HE LUNATIC ASYLUM;