lung cancer:what’s new and what’s old?
DESCRIPTION
Lung Cancer:What’s New and What’s Old?. Presented By Leora Horn at 2014 ASCO Annual Meeting. Outline Slide. Presented By Leora Horn at 2014 ASCO Annual Meeting. Slide 3. Presented By Leora Horn at 2014 ASCO Annual Meeting. LUX-Lung 3 and 6: design . - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/1.jpg)
Lung Cancer:<br />What’s New and What’s Old?
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 2: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/2.jpg)
Outline Slide
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 3: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/3.jpg)
Slide 3
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 4: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/4.jpg)
LUX-Lung 3 and 6: design
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 5: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/5.jpg)
Combined OS analysis: common mutations (n=631)
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 6: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/6.jpg)
Combined OS analysis: mutation categories
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 7: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/7.jpg)
JO25567 Study Design
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Primary endpoint: PFS by independent review
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 9: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/9.jpg)
PFS by EGFR Mutation Type
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 10: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/10.jpg)
Acquired Resistance to EGFR TKIs
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 11: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/11.jpg)
Phase I Trials With Third Generation EGFR Inhibitors
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 12: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/12.jpg)
Phase I Trials
Presented By Leora Horn at 2014 ASCO Annual Meeting
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AZD9291: Response rate* in T790M+ (central test)
Presented By Leora Horn at 2014 ASCO Annual Meeting
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CO-1686: Best response in Phase 1 and early <br />Phase 2 expansion cohort patients
Presented By Leora Horn at 2014 ASCO Annual Meeting
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HM61713: Response in T790M Cohort
Presented By Leora Horn at 2014 ASCO Annual Meeting
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RADIANT Trial Design
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Disease-free Survival KM Plot – FAS
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 18: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/18.jpg)
Slide 18
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 19: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/19.jpg)
Slide 19
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 20: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/20.jpg)
Summary
Presented By Leora Horn at 2014 ASCO Annual Meeting
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PROFILE 1014 Study Design
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Primary Endpoint Met: Crizotinib Superior to Pemetrexed-based Chemotherapy in Prolonging PFSa
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 23: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/23.jpg)
ASCEND-1 Study Design
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Progression-Free Survival in Patients with ALK+ NSCLC
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 25: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/25.jpg)
Summary
Presented By Leora Horn at 2014 ASCO Annual Meeting
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REVEL: Study Design
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Overall Survival<br />ITT Population
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Study Design: Squire
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Slide 29
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Summary
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 31: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/31.jpg)
CREST Trial Design
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Overall survival
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 33: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/33.jpg)
PCI in SCLC: Trial Design
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Time to Brain Metastasis
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Overall Survival
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 36: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/36.jpg)
Summary
Presented By Leora Horn at 2014 ASCO Annual Meeting
![Page 37: Lung Cancer:What’s New and What’s Old?](https://reader035.vdocuments.net/reader035/viewer/2022062812/568163c2550346895dd4e977/html5/thumbnails/37.jpg)
KEYNOTE-001: First line therapy with MK3475 in patients with PD-L1 positive NSCLC
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Antitumor Activity by MK-3475 Dose
Presented By Leora Horn at 2014 ASCO Annual Meeting
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Conclusions
Presented By Leora Horn at 2014 ASCO Annual Meeting