lymphatic filariasis by morgan mcbride. lymphatic filariasis is one of the oldest known diseases
TRANSCRIPT
LYMPHATIC FILARIASISBy Morgan McBride
Lymphatic Filariasis is one of the oldest known diseases
“In 1997, the World Health Assembly called upon Member States to develop national plans that would lead to the elimination of LF. In 2000, the World Health Organization (WHO) established the Global Programme to Eliminate Lymphatic Filariasis (GPELF), which has the goal of eliminating lymphatic filariasis as a public-health problem by the year 2020.” -World Health Organization
The story of Hamisu Isa, age 35, from Nigeria
Lymphatic Filariasis is an Infection of the lymph nodes caused by parasitic nematode worms
https://www.neb.com/tools-and-resources/feature-articles/combating-neglected-diseases-a-genomic-approach-to-identify-potential-drug-targets
3 types of filarial nematodes cause LF
• Wuchereria bancrofti*• Brugia malayi• Brugia timoria
http://www.nematodes.org/research/nematodes/fgn/
The parasite is transmitted through a mosquito vector
http://www.2minutemedicine.com
Life cycle: vectorhumanvector
Life cycle: vectorhumanvector
LF affects the lymph system
http://www.mayoclinic.org
Due to the slow progress of the disease, most people are in the
asymptomatic stage of symptoms.
Chronic Symptoms include, lymphedema elephantiasis, paralysis, and hydrocele
jama.jamanetwork.com
The most accurate way to diagnose is the Circulating filarial antigen detection method
LF can only be managed with treatments
• Diethylacarbamazine (DEC)• Ivermectine• Albendazole
http://mumbai.all.biz/diethylcarbamazine-g58199
http://es.made-in-china.com/co_helipharma/product_Ivermectin-1-_heeguigng.html
http://yourmedicinecorner.blogspot.com/2012/06/albendazole-for-filariasis-facts.html
Combination of Albendazole with DEC or Ivermectine is recommended for most effective treatment
The drugs cannot reverse the affects of chronic conditions, so they must be managed
http://www.filariasis.org/management.html
Prevention by lowering the chance of being bitten is key
science.nationalgeographic.com
Let’s go back to Hamisu
LF is a “Neglected Tropical Disease” of the Developing
World.
http://www.cehjournal.org
Approximately 120 million people in 81 countries are infected with Lymphatic Filariasis
LF is the leading cause of permanent and long-term disability. More than 30% of the 120 million people are severely disabled.
Increased disability results in economic concerns in endemic countries
Is there hope for those at risk? And those with the disease?
World Health Organization’s GPELF program has 2 goals
• Stop transmission• Alleviate suffering
and disability
Stop transmission through Mass Drug Administration (MDA)
Data from 2010 to show progress made within GPELF
Mass Drug Administration (MDA) is most effective with the use of several rounds of drugs
Between 2000-2009 2.8 billion doses of medicine were delivered to 845 million people.
There is hope for eradicating LF from the World
Works Cited• "Diagnosis." Centers for Disease Control and Prevention. Centers for Disease Control and
Prevention, 01 Apr. 2014. Web. 24 Nov. 2014. • "Frequently Asked Questions (FAQs)." Centers for Disease Control and Prevention. Centers
for Disease Control and Prevention, 14 June 2013. Web. 24 Nov. 2014. • "Lymphatic Filariasis." - MicrobeWiki. N.p., n.d. Web. 24 Nov. 2014. • "Lymphatic Filariasis – Stories From the Field: Hamisu Isa." Lymphatic Filariasis – Stories
From the Field: Hamisu Isa. N.p., n.d. Web. 24 Nov. 2014. • "Lymphatic Filariasis." Global Network |. N.p., n.d. Web. 24 Nov. 2014. • "Lymphatic Filariasis." WHO. N.p., n.d. Web. 24 Nov. 2014. • Ottesen, Eric A., et al. "The global programme to eliminate lymphatic filariasis: health impact
after 8 years." PLoS neglected tropical diseases 2.10 (2008): e317 • Taylor, Mark J., Achim Hoerauf, and Moses Bockarie. "Lymphatic filariasis and
onchocerciasis." The Lancet 376.9747 (2010): 1175-1185.• "USAID's NTD Program." USAID's Neglected Tropical Disease Program: Target Diseases,
Lymphatic Filariasis. N.p., n.d. Web. 24 Nov. 2014. • "USAID's NTD Program." USAID's Neglected Tropical Disease Program: Target Diseases,
Lymphatic Filariasis. N.p., n.d. Web. 24 Nov. 2014. • "Wuchereria Bancrofti - Lymphatic Filariasis - Elephantiasis." Wuchereria Bancrofti -
Lymphatic Filariasis - Elephantiasis. N.p., n.d. Web. 24 Nov. 2014.