magnetic fluid hyperthermia

8/4/2019 Magnetic Fluid Hyperthermia

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Magnetic Fluid Hyperthermia:Focus on SuperparamagneticIron Oxide Particles (SPIONs)

Sophie Laurent, Silvio Dutz, Urs O. Hfeliand Morteza Mahmoudi


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OBJECTIVES

Acknowledge the use of SPIONs aspossible means for treating cancer

Provide a more efficient way of killingcancer cells through magneticnanoparticles

Conduct more studies regarding thefeasibility of SPIONS as possible curefor cancer


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MAGNETIC FLUID HYPERTHERMIA

A promising technique for treatingcancer cells

Refers to the heating of tissues usingmagnetic nanoparticles at 42-45C


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TYPES OF HYPERTHERMIA

Local hyperthermia

Regional hyperthermia

Whole body hyperthermia


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WAYS OF INTRODUCING MAGNETICNANOPARTICLES (MNP)

Arterial injection

Direct injection

In situ implant formation Active targeting


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SPIONs

Superparamagnetic iron oxide particles

Occur in two forms

Magnetite (Fe3O

4)

Maghemite (-Fe2O3)


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Characteristics of SPIONS

Biocompatibility

Nontoxicity

Ability to escape from thereticuloendothelial system (RES)

Low protein adsorption


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Why coat SPIONs?

Preventing the opsonization of SPIONs

Avoiding agglomeration of SPIONs inbiological medium

Achieving the desired surface charge for theSPIONs surface main task

Preserving the functionalities of thenanomaterials

Exhibiting the protein adsorption on theSPIONs and their corresponding denaturation

Ensuring biocompatibility of SPIONs


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HOW IS IT DONE?

MAGNETIC

NANOPARTICLES


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High Frequency Induction Machinefor Hyperthermia


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Schematic diagram for hyperthermia


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Predicted and actual SPION andtemperature distribution for recurrent

cervical cancer


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Predicted and actual SPION andtemperature distribution for recurrent

prostate carcinoma


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RESULTS AND DISCUSSIONS


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Balivada et.al. Magnetic Hyperthermia ofMelanoma Mediated by Iron oxide CoreNanoparticles, 2010

Influence of biomagnetic Fe3O4core/shell MNP combined with shortexternal alternating magnetic field

exposure on the growth ofsubcutaneous mouse melanomas

Decrease in tumor size was observedafter IV administration of the MNPfollowed by three consecutive days ofAMF exposure 24 h after injection


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Matsuoka et. al. Hyperthermia Using MagnetiteCationic Liposomes for Hamster Osteosarcoma2004

Investigated the effect of magnticcationic liposomes in vivo as treatementfor hamster osteosarcoma

Tumor was heated above 42C andcomplete regression was observed in100% of the treated group hamsters


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Matsuoka et. al. Hyperthermia Using MagnetiteCationic Liposomes for Hamster Osteosarcoma2004

Investigated the effect of magnticcationic liposomes in vivo as treatementfor hamster osteosarcoma

Tumor was heated above 42C andcomplete regression was observed in100% of the treated group hamsters


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Tseng et.al. Nanobiotechnology 2009

Developed a feedback temperaturesystem to keep the MNP at a constanttemperature to prevent overheating in

the tumors

Authors found experimentally that thesurvival rate of cancer cells could be

greatly reduced when CT-26 cancer cellswere heated above 45C.


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Le Renard et.al. Hyperthermia 2009

Investigated a new heat deliverytechnique for the local treatment ofsolid tumors injecting a formulation

that solidifies to form an implant in situ

After treatement with 12 mT field, five ofeleven mice (45%) survived one year

without any tumor recurrence


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CONCLUSIONS

SPIONs play an important role in thedevelopment of hyperthermia fortreatment of tumors in vivo.

SPIONs are very suitable to serve asheating source during magnetic fluidhyperthermia and further research in thefield will lead to a feasible solution orreduction of the abovementioned

problems which enables a more profoundtesting of this promising therapeuticmethod for cancer treatment.

magnetic fluid hyperthermia

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