major histocompatibility complex...presence of multiple alleles in the population for a given locus....
TRANSCRIPT
MHC
• Haplotype: – The set of alleles present on each
chromosome – Outbred individuals have 2 haplotypes – Inbred individuals have 2 identical
haplotypes
• MHC molecules are co-dominantly expressed.
Inbred Mice
• In a given inbred strain of mice, every mouse is genetically identical to every other mouse in that strain. – Syngenic – Allogenic
• Strains or individuals express different alleles.
Graft Nomenclature • Isograft
– Graft from one individual to itself
• Syngenic – Graft between identical individuals
• Allograft – Graft between individuals of different strain.
• Xenograft – Graft between different species
Diversity • MHC molecules exhibit a high degree of
diversity • Diversity is due to polymorphism or the
presence of multiple alleles in the population for a given locus.
• The sequence variation between alleles is clustered to the α1/α2 and α1/β1 regions of class I and class II molecules respectively.