Malaria Vaccinations

Why A Vaccine ?Because…..

The Drug Resistance .

EvolutionThe Malaria Parasite routinely get drug resistance to anti-malarial drug.

Mosquito Net.It Reduces about 40% Incidence of Malaria.

It Will Not Give 24X7 Hour Protection.

We Use Insecticides.To Reduce Mosquito Population.

Resistance.They Routinely Get Resistance To Insecticides.

So We Don’t Have a Mosquito Free Zone.

This Situation will Continue...

After the successful story of Small pox to Polio to Whooping Cough vaccines;We have the best choice ofcost-effective and efficacious means of preventing disease and death.

The Vaccination

Target

Our Aim Is To Break The Cycle Of The Malaria Parasite.

Where We Can Do ?

Our Area Of Targets AreA. Pre-erythrocytic StageB. Erythrocytic StageC.Post-erythrocytic

A.Sporozoite

B.Infected Hepatocytic

C.Asexual Erythrocytic

D.Sexual Erythrocytic

And Targeting Against

Types of malaria vaccines1.Pre-erythrocytic vaccine candidates2.Blood-stage vaccine candidates3.Transmission-blocking vaccine candidates

Considerations to be made in selecting the most suitable vaccine.1. How Accessible is the antigen to the immune system?2. How Susceptible is the antigen to evolutionary change?3. How critical is the antigen to parasitic Biological Functions?4. How likely is a Protective response in animal models?5. Does the antigen contain epitopes that are Recognisable by HLA allele super families?6.How compatible is the antigen with other potential antigens?

RTS,S Malaria Vaccine Candidate

RTS,S is the world’s most clinically advanced malaria vaccine candidate.

Its early development, beginning in the 1980.

GSK , Walter Reed Army Institute the PATH Malaria Vaccine Initiative (MVI)—with grant money from the Bill & Melinda Gates Foundation.