management of uterotonic drugs used for amtsl name of presenter prevention of postpartum hemorrhage...

Management of uterotonic drugs used for AMTSL

Name of presenter

Prevention of Postpartum Hemorrhage Initiative (POPPHI) ProjectPATH

Objectives

• By the end of this topic, learners will be able to:

• Describe recommendations for storing uterotonic drugs used for AMTSL.

• Describe the importance of documenting uterotonic drug use and movement.

• Identify problems related to poor documentation of uterotonic drugs.

• Estimate the quantity of uterotonic drugs to order for your facility

3b - 1

Consequences of poor drug management 3b - 2

Hm….maybe that’s because she doesn’t want to be bothered with

managing our drugs.

We don’t have any more oxytocin.

Estimating uterotonic drug needs

• The estimate of the drug and dosage forms required for a given period is undertaken

– To avoid shortages (out of stock) and ensure credible health care service,

– To prevent excess stock and avoid waste (loss or mismanagement of financial resources).

3b - 3

Estimating uterotonic drug needs

• Factors that influence choice and quantity of drugs include:

– Population which the health institution serves.– Volume of birth.– Seasonal variation in number of births to be

expected.– Monthly (rate of) drug consumption.– Delivery (lead) time.– Time lag between placing orders and receiving the

orders.– Request indicator (re-order level): Quantity of drug

product that serves as a signal for re-ordering.

3b - 4

Terms used for drug management

• Request indicator (RI)• Average monthly

consumption• Delivery (lead) time• Quantity to be requested• Stock in balance

Maybe I ordered too much….

3b - 5

Review of calculations

• Average monthly consumption

• Divide the total consumption over the period by the number of months the drug was consumed.

• Request indicator (time for re-ordering) = May also be known as “Minimum stock level”

• Average monthly consumption × delivery time

• Quantity to order

• (Average monthly consumption × Lead time) + (1 month consumption for unforeseen events) +/- (difference between RI and Stock in balance)

3b - 6

Case study – Work with a learning partner

Refer to Learning Activity 3.4, question 1 (page 17 in the Learner’s Notebook):

The pharmacy manager is preparing her monthly order request and would like to calculate how many ampoules of oxytocin 10 IU to order. When she carried out an inventory, she counted 50 ampoules of oxytocin 10 UI, of which 4 ampoules were expired. The average monthly consumption is 30 ampoules of oxytocin (10 UI). How many ampoules should the pharmacy manager order?

3b - 7

Case study – Answer

Quantity to order = (Average monthly consumption × Lead time + 1 month consumption for unforeseen events) – (Stock in balance over RI)

Delay (lead) time : 1 month

Stock in balance : (50 ampoules – 4 expired ampoules) = 46 ampoules in balance

Average monthly consumption : 30 ampoules

RI : (30 ampoules x 1 month) = 30 ampoules

Stock over RI = 30 – 46 = 16 ampoules over RI

Quantity to order : [(30 x 1) + (30)] – (16) = 44 ampoules

3b - 8

Quality assurance

• In areas where medications are stored …

…what can affect the quality of medications you use ?

Temperature

Humidity Light

Dirt

3b - 9

Small Group WorkReview of uterotonics

• Find one partner to work with.

• Refer to learning activity 3.5, question 1 (page 19 in the Learner’s Notebook).

• Answer the questions about stability of uterotonics by studying sections Keeping uterotonic drugs effective and Tips to increase uterotonic drug effectiveness on pages 34-36 in the Learner’s Guidebook.

3b - 10Small Group WorkReview of uterotonics


• Refer to learning activity 3.5, question 1 (page 19 in the Learner’s Notebook).

• Answer the questions about stability of uterotonics by studying sections Keeping uterotonic drugs effective and Tips to increase uterotonic drug effectiveness on pages 34-36 in the Learner’s Guidebook.

3b - 10

Stability when exposed to light*

Stability when exposed to heat*

Ergometrine MisoprostolOxytocin

*Most stable: 1; Least stable: 3

3b - 11

Stability when exposed to light*

Stability when exposed to heat*



3b - 11

Answers

312Stability when exposed to light*

312Stability when exposed to heat*



3b - 12Answers

312Stability when exposed to light*

312Stability when exposed to heat*



3b - 12

Small Group WorkStorage of uterotonics

• Divide into 4 groups to work on case studies in Learning activity 3.5, question 2 on pages 19-20 in the Learner’s Notebook.

• Group 1 – work on case study #1; Group 2 – work on case study #2; Group 3 – work on case study #3; Group 4 – work on case study #4.

• Each group has 10 minutes to work through the case study. Use Table 3-2 (pages 34-35), Recommended guidelines for transport and storage of uterotonic drugs, and the section Tips to keep uterotonic drugs as effective as possible in the Learner’s Guidebookfor guidance.

3b - 13Small Group WorkStorage of uterotonics

• Divide into 4 groups to work on case studies in Learning activity 3.5, question 2 on pages 19-20 in the Learner’s Notebook.

• Group 1 – work on case study #1; Group 2 – work on case study #2; Group 3 – work on case study #3; Group 4 – work on case study #4.

• Each group has 10 minutes to work through the case study. Use Table 3-2 (pages 34-35), Recommended guidelines for transport and storage of uterotonic drugs, and the section Tips to keep uterotonic drugs as effective as possible in the Learner’s Guidebookfor guidance.

3b - 13

Quality assurance : Temperature

• In the pharmacy :• Make sure that there is a system in place to monitor

the temperature of the refrigerator / cold box • Make sure that there is a back-up system in place in

case of frequent electricity cuts - for example, gas or solar refrigerators, placing ice packs in the refrigerator to keep it cool, etc.

• Store misoprostol at room temperature and away from excess heat and moisture

• To ensure the longest life possible of injectable uterotonics, keep them refrigerated at 2–8°C

• Protect ergometrine and Syntometrine from freezing and light. .

3b -14

Quality assurance : Temperature

• In the delivery room :• Check the manufacturer’s label for recommendations

on how to store injectable uterotonic drugs outside the refrigerator. In general:

Oxytocin may be kept outside the refrigerator at a maximum of 30°C (warm, ambient climate) for up to three months and then discarded

Ergometrine and Syntometrine vials may be kept outside the refrigerator in closed boxes and protected from the light for up to one month at 30°C and then discarded

Misoprostol should be stored at room temperature away from excess heat and moisture

3b -15

• In the delivery room :• Record the temperature in the delivery room on a

regular basis, preferably at the hottest times of the day

• Periodically remove ampoules from the refrigerator for use in the delivery room – carefully calculate the number removed from the refrigerator based anticipated need

• Only remove ampoules or vials from their box just before using them

• Make sure that there are adequate stocks of syringes and injection safety materials

• Avoid keeping injectable uterotonics in open kidney dishes, trays, or coat pockets

Quality assurance : Temperature (2)

3b -16

Rotation and stocking

These expire later than the tins behind them. Which should

I use first?

• Use the system of: FIRST IN FIRST OUT (FIFO)

• Keep track of expiration datesRecord all drugs that have been used or sold

• Regularly conduct a physical inventory of the stock in balance

• FIRST TO EXPIRE FIRST OUT (FEFO)

3b -18

Disposal of expired/broken stocks

• Clearly identify and document any ampoules that are expired or have been broken

• If an ampoule has expired or broken: • Do not keep it with stock to be distributed/used. • Put all broken or expired ampoules in a closed safety

box that is clearly labeled “Expired, do not use.” • Store the safety box at a safe distance from stock to be

distributed/used. • Subtract any expired or broken ampoules from the

balance in stock as soon as they are taken out of the stock to be distributed/used.

• Apply national protocols for destruction or return of expired or broken ampoules.

3b -19

Case studyFind the error


• Refer to learning activity 3.4, question 4 (pages 17-18 in the Learner’s Notebook).

3b -20

Recording use of uterotonic drugs

Tools for keeping track of uterotonic drugs include:

• Order book• Stock cards • Daily log of uterotonic drug

use • Delivery register• Oxytocin logbook in the

delivery room

3b -21

Recording movement of medications (2)

Document movement of

uterotonic drugs in at least two

different management tools to

guarantee accurate information

and accountability

3b -22

Summary

• It is advisable to request drugs on a regular basis to prevent shortages.

• If drugs are not always available, patients may lose confidence in the health centre and will be discouraged from visiting it.

• It is important to make requests on a regular basis, as drugs will only be delivered when requested.

• The delivery time should be taken into consideration in ensuring that drugs are not in short supply.

• If drugs are available but not stored in a way that keeps them effective, money will be wasted and quality of care affected negatively.

3b -23

Learning activities

• Please complete learning activities found in the Learner’s Notebook for Session 3b.

• You may work individually or in groups on the learning activities during breaks, in the evening, or in the clinical area when there are no clients.

• You may correct your answers individually or with another participant or the facilitator.

• See a facilitator if you have questions.

3b -24