managing cognitive and emotional changes associated with nph

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Managing cognitive and emotional changes associated with NPH Jeannine Morrone-Strupinsky, Ph.D., ABPP-CN October 30, 2012

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Managing cognitive and emotional changes associated with NPH. Jeannine Morrone -Strupinsky, Ph.D., ABPP-CN October 30, 2012. Plan of talk. Review cognitive changes associated with NPH Offer suggestions for managing cognitive changes Review mood/behavioral changes associated with NPH - PowerPoint PPT Presentation

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Page 2: Managing cognitive and emotional changes associated with NPH

Plan of talk Review cognitive changes associated with NPH Offer suggestions for managing cognitive

changes Review mood/behavioral changes associated

with NPH Offer suggestions for managing mood/behavioral

changes Q & A

Page 3: Managing cognitive and emotional changes associated with NPH

NPH—A Brief Review

First described in 1965.

Abnormal buildup of CSF in the ventricles with high normal CSF pressure.

Enlargement of the ventricles causes stretching of surrounding brain tissue (neurons) and blood vessels, particularly in the frontal lobes.

Page 4: Managing cognitive and emotional changes associated with NPH

How NPH looks in the brain

CT head scan of a patient with normal pressure hydrocephalus showing dilated ventricles. The arrow points to arounded frontal horn.

T2-weighted MRI showing dilatation of ventricles out of proportion to sulcal atrophy in a patient with normal pressure hydrocephalus.

Normal MRI

www.emedicinehealth.com

Page 5: Managing cognitive and emotional changes associated with NPH

NPH—A Brief Review

Can occur in people of any age, but is most common in older adults (60s and 70s).

Secondary NPH is the result of brain injury/insult (e.g., trauma, infection, tumor).

“Idiopathic” NPH is due to unknown causes. NPH may account for up to 5% of individuals

with dementia.

Page 6: Managing cognitive and emotional changes associated with NPH

Clinical triad

Incontinence Inability to hold urine Frequent urination Urgency to urinate

Gait disturbance Unsteadiness Wide-based gait Leg weakness Sudden falls Shuffling steps Difficulty taking first step because feet are “stuck” to the floor “freezing” while walking

Cognitive impairment (next slide)

Page 7: Managing cognitive and emotional changes associated with NPH

Cognitive Effects of NPH

Slowing down of thoughtsMemory impairment—decline in active

retrieval (immediate and delayed recall) with preserved memory storage (recognition)

Visuospatial perception and visuoconstruction may be impaired

Absence of aphasia, apraxia, and agnosia (“cortical features” seen in AD)

Impairment in executive functions

Page 8: Managing cognitive and emotional changes associated with NPH

Cognitive Effects of NPHExecutive functions (“CEO” of the brain)

Planning (and prioritizing) Thinking in a flexible manner (adjusting to

changing situations, coming up with new solutions)

Concentration/working memory (i.e., dialing new phone numbers)

Abstract thinking (learning from experience by extracting broader meaning of events)

Managing time Initiating appropriate actions and inhibiting

inappropriate actions (impulsivity)Selecting relevant sensory information

(focusing attention on what is relevant; i.e., being able to filter out background noise)

Page 9: Managing cognitive and emotional changes associated with NPH

Cognitive Effects of NPH

Regarding memory, individuals with NPH display impaired free recall of information but tend to benefit from cues and show relatively spared recognition. This has led some to propose that the mechanism of memory failures may be retrieval search while the storage capacity is preserved.

Memory retrieval is performed by the frontal lobes (affected by bulging ventricles).

Page 10: Managing cognitive and emotional changes associated with NPH

Effects of shunting on cognitive impairment

NPH is described as a reversible form of dementia.

However, statistics vary considerably regarding cognitive improvement (30-40% in INPH and 50-70% in secondary NPH).

Memory tends to improve more than executive functions.

More improvement is seen in younger individuals and in women, and in those without other causes of impairment.

Gait impairment and urinary incontinenceare more likely to improve.

Page 11: Managing cognitive and emotional changes associated with NPH

5 reasons why a neuropsychological examination is requested by a physician

¨ To find possible problems with brain functioning.

¨ To help clarify a patient’s diagnosis.¨ To define an individual’s relative brain-related

strengths and weaknesses.¨ To guide treatment, or to help patients make

educational or vocational decisions.¨ To determine whether or not there are any

changes in a patient’s cognitive and emotional functions over time.

National Academy of Neuropsychology

Page 12: Managing cognitive and emotional changes associated with NPH

Role of the neuropsychologist¨ A neuropsychological examination is a

systematic and scientifically-based assessment of a person’s thinking, problem-solving, and memory capacity that may reveal something about the state of brain function.

¨ The pattern of test findings allows the examining clinician to develop an informed opinion about the patient’s higher cerebral functioning.

¨ Ultimately, the physician must integrate results from a variety of tests to determine the diagnosis.

Page 13: Managing cognitive and emotional changes associated with NPH

Compensating for cognitive difficulties in NPH

If the person with NPH has difficulty shifting tasks quicklygive adequate notice that he or she needs to get

ready to go somewherepost an agenda for the day

If the person with NPH has difficulty focusing reduce background distractionsperform only one activity at a time, and try to

complete the activity before starting another activity

take frequent breaks to allow the individual to regroup

Page 14: Managing cognitive and emotional changes associated with NPH

Compensations for cognitive difficulties in NPH

If the person with NPH has difficulty sequencinguse procedural checklists (i.e. to program TiVo, cook

meals, follow a grooming routine)

If the person with NPH has difficulty making decisions limit choices/provide optionsuse concrete examplesbreak down large projects into component parts

Page 15: Managing cognitive and emotional changes associated with NPH

Compensating for cognitive difficulties in NPH

If the person with NPH has difficulty recalling information use a memory notebook, day planner, or voice recorder use placards use a beeping watch/timer to remember to do something (i.e., turn off

hose in the yard) use a pill box use forms to remember to do things that occur periodically (i.e., change

air filters) provide cues to aid memory use organizing strategies (grouping) face-name recall technique

Page 16: Managing cognitive and emotional changes associated with NPH

Face-name recall technique

Focus on the name. Repeat it to yourself several times. Associate the name with something already stored in

your memory. If you know someone with the same name, that will be the

association. Visualize an image of the new person with the person you already know who has the same name.

If the person has a name that you do not know, create an association by breaking down the name into words to which you form visual images.

Visualize the person with the visual images you have created. Drawing a picture with the association or making up a short story about the images helps even more.

Page 18: Managing cognitive and emotional changes associated with NPH

Grouping example

Read the following list of sports one time. When you are done, write down as many of the sports as you can without looking back at the list.

snow skiing basketball tennislong jump bobsledding 100-m dashhockey baseball ice skatingdiscus golf high jumpvolleyball javelin soccerluge curling cricketdecathlon hurdles

www.utexas.edu/student/utlc/class/mkg_grd/improving.html

Page 19: Managing cognitive and emotional changes associated with NPH

Grouping example

You can organize material by grouping similar concepts, or related ideas together.

For exampleWinter sportsTrack and field sportsSports using a ball Individual sportsTeam sports

www.utexas.edu/student/utlc/class/mkg_grd/improving.html

Page 20: Managing cognitive and emotional changes associated with NPH

Another grouping example…

Page 21: Managing cognitive and emotional changes associated with NPH
Page 22: Managing cognitive and emotional changes associated with NPH

NPH and mood changes Depression is present in some individuals with NPH.

Average prevalence of major depressive disorder in the elderly population is 1.8%.

DSM-IV criteria for depression (>5 of the following):depressed mooddecreased interest (apathy*) or pleasure in activities

(anhedonia)significant weight loss* insomnia* or excessive sleep*psychomotor retardation or agitation loss of energy (anergia)* feelings of inappropriate guilt recurrent thoughts of death

Page 23: Managing cognitive and emotional changes associated with NPH

Differentiating depression from apathy

Sometimes it looks like the individual with NPH is depressed, but rather s/he is apathetic or is unconcerned or unaware of his or her condition.

Apathy is defined as a primary loss of motivation, loss of interest, and loss of effortful behavior, features also present in depressed individuals.

This is likely due to disruption of medial frontal lobe functioning due to bulging of the ventricles into the brain tissue.

Page 24: Managing cognitive and emotional changes associated with NPH

Treatment of depression in NPH Treatment of depression in NPH is important because

depression has a negative influence on cognitive performance, activities of daily living, and perceived quality of life.

In the case of mild depression, options include behavioral activation and/or supportive psychotherapy.

A clinical psychologist or social worker can be helpful in this adjustment period, particularly in helping identify life stressors that may be contributing to the depression.

Psychotherapy also helps the individual with NPH accept the diagnosis, employ coping strategies, and work through the emotional consequences of having to deal with the diagnosis.

Page 25: Managing cognitive and emotional changes associated with NPH

Treatment of depression in NPH, cont’d

A long-term plan must then be structured to minimize stress and improve quality of life. Patients should be encouraged to develop a daily exercise routine within their capabilities.

In case of more significant depression, pharmacological treatment is warranted (antidepressant medication).

Keenan et al. (2005) demonstrated a reduction in reported symptoms of apathy following a dose of methylphenidate, which increases the action of dopamine, a chemical in the brain.

Page 26: Managing cognitive and emotional changes associated with NPH

NPH and sleep disturbance

Individuals with NPH may experience sleep disturbance. This can be due to changes in mood or in the functioning of brain regions associated with sleep.

Practicing sleep hygiene can improve sleep.Go to bed the same time every night.Keep bedroom cool, dark, and quiet.Use the bedroom only for sleep and intimacy.Get up and do something sedentary if you are

unable to fall asleep.

Page 27: Managing cognitive and emotional changes associated with NPH

“Pseudodementia” in NPH A common referral question is the differentiation

of cognitive dysfunction caused by NPH from a “pseudodementia” attributable to depression.

Patients with NPH and depression show worse cognitive performance when compared with patients without depression, particularly on tests of executive functioning.

Depression and even mild cognitive impairment contribute significantly to disability inpatients with NPH.

Page 28: Managing cognitive and emotional changes associated with NPH

Salvador Dalí. (Spanish, 1904-1989). The Persistence of Memory. 1931.