Managing Hereditary Angioedema

Setting the StageBurden of Disease in HAE

Burden of Disease in HAE (cont)

C1 Esterase Inhibitor for Treatment of Laryngeal Attacks in HAE

Other Therapies Approved For On-Demand Treatment of HAE Attacks

Ecallantide Efficacy

Icatibant FAST-3 Trials

Icatibant Reinjection Rates

C1 Inhibitor Use in Children

C1 Inhibitor Use in Children (cont)

C1 Inhibitor Use in Children for Short-term Prophylaxis

MacGinnitie et al Study of Ecallantide Treatment for Pediatric

HAE

Treatment Outcomes With Ecallantide vs Placebo

C1 Inhibitor Dose-escalation Study

C1 Inhibitor Dose-escalation Study (cont)

The Successes in 14 Patients

Treatment Failures

Impact of HAE Prophylaxis on QoL

Effects of C1 Inhibitor Prophylaxis vs On-demand Therapy on QoL

SF-36 Norm-based Domain and Component Summary Scores

Recommendations for Managing HAE

Recommendations for Managing HAE (cont)

Abbreviations

References

References (cont)

References (cont)

References (cont)