manipal institute of technology 2017 - e... · manipal institute of technology manipal 576104,...

I am glad to know the Dept of Chemistry, Manipal Institute of Technology is organizing an

International Conference on Emgering Trends in Chemical Sciences. The subject of Chemical

Sciences has assumed great importance in furthering the development of modern scientific world

with contributions from researches and other professionals. I wish the deliberations great success.

President & Chancellor

Message

Dear all,

I am very happy to express my greetings through this message on the occasion of the three day

International Conference on Emerging Trends in Chemical Sciences (ICETCS-2017) from the

14th to 16th September 2017, organized by the Department of Chemistry of this institute.

Chemistry is one of first and foremost basic science teaching departments started in 1957 in MIT.

With well-developed laboratory, the department started its Post Graduate Degree program in

2009 and has grown to the new heights and looking for better growth is worth appreciations.

The Chemistry field assembles a broad range of scientific disciplines to discover, design and

deliver new materials, chemicals, drugs and therapies that has fascinating utilities to the mankind.

The scope of these gatherings is also extended by remarking key regulatory and industrial fields.

Chemistry conferences are gathering of group of people to share their research ideas and

knowledge of specific techniques and topics that are emerging in chemistry field. A platform such

as this international conference provides a great opportunity to the engineers and scientists to get

to know the latest endeavors in the field and use the opportunity to interact with experts from

academia.

My appreciations to the organizing team members, to the members of different committees and

to the faculty members of Chemistry Department who have taken great efforts to conduct this

conference.

I take this opportunity to extend my warm welcome to the resource persons and the delegates

registered for the Conference and I extend my best wishes to organizers and participants'

success in its endeavors.

Director

Message

It is with great pleasure, I welcome all the distinguished guests and delegates of the “International

conference on Emerging Trends in Chemical Science” (ICETCS-2017) held on 14 -16 September

2017. As the year 2017 marks a remarkable milestone in the glorious journey of MIT, the

Department of Chemistry is elated to host this event on Diamond Jubilee celebration of the

institution.

The conference program features a wide variety of keynote, plenary, invited, contributed lectures

and poster sessions. The conference provides a platform for a panel of experts working at the

forefront of chemical sciences from academic institutes, research laboratories and industry. I am

positive that the deliberations at the conference will provide new directions and enrich young

researchers from academia and industry. This conference will engage the participants on relevant

issues in Synthetic and Medicinal Chemistry, Modern Advanced Materials Chemistry, Green

Chemistry, Electrochemical Power Sources, Corrosion, Nanomaterials, Computational Chemistry

and related topics.

I am grateful to the speakers and delegates from various universities across the globe and India,

and organizations such as DRDO, BRNS, IITs, CSIR Laboratories, SABIC International, Asian

Paints for responding to our invitation enthusiastically. Your presence has made this event

successful and meaningful. My special thanks to valued sponsors-DRDO, Bruker, Shri

Siddhivinayaka Agency, BSB Edge Pvt. Ltd, Sri Durga Lab.Mahalasa Agencies and so on for

making this event possible. I am immensely grateful to our administrators for the constant

support and to every member of the organizing and working committee for the wholehearted

cooperation.

With warm regards

Pro . r. .P. asho a

Convener ICETCS-2017

Message

Message

I am very glad to know that the department of chemistry is organising a three-day International

Conference on Emerging trends in Chemical Sciences, as a part of diamond jubilee celebration of

MIT Manipal. This is being an interdisciplinary conference, I am sure there will be a fruitful

interaction among the researchers from various fields. An overwhelming response from the

authors will certainly enhance the quality of the papers which will be presented in the conference.

I wish Dr Yashoda, Head of the department of Chemistry and her team a very best for this event.

r Nara ana a ahit

Registrar - Manipal University

Message

It is a pleasure to note that the Department of Chemistry is organizing an International Conference

on 'Emerging Trends in Chemical Sciences,' during the Diamond Jubilee year of our Institute. I

understand that the theme encompasses the various recent findings in the vast sphere of

Chemistry. In the fast changing times that we live in, it is very obligatory that academicians,

technologists and researchers come together and meet the challenges that we face. I am sure that

such Conferences would provide ample opportunities to all participants to exchange their views."

r PaiJoint Director

Programme Schedule ICETCS-2017

Venue: ir . . all A a e i lo -2Day: 01 14-09-2017

10.45 - 11.30 am Pro . an a a

Former Vice-Chancellor, University of Mysore & KSOU, India - - ST -

e note-1

e note-211.30 - 12.30 pm r. an ee u ar

Professor, Raman Research Institute, C I C T I S

12.30 - 12.45 pm

12.30 - 2.00 pm (Venue: MIT Food Court)

Session Chairs: T

2.00 - 2.45 pm T-01 r. T otresh E E -S S

2.45 - 3.15pm T-01 r. austa h u ar aiti Senior Scientist, CSIR-NIIST, Thiruvananthapuram, Kerala, India E - T S

3.15 - 3.30 pm Tea break

3.30 - 5.00 pm Oral presentations: OP-01 to OP-09

3.30 - 5.00 pm Poster presentations: PP-01 to PP-30

7.00 pm onwards Cultural evening & Gala dinner

Venue Fortune- in-Valley View International, Manipal

Ti e ent

8.00 - 9.00 am Breakfast & Registration

8.00 - 9.30 am Registration

9.30 -10.30 am Inauguration

10.30 - 10.45 am Tea Break

Te hni al ession

1


Day: 02 15-09-2017

Ti e ent

8.00 - 9.00 am Breakfast

Venue: ir . . all A a e i lo -2 8.00 - 9.45 a

9.00 - 9.45 am T-02 r. rna uli ati Department of Chemical Engineering, Faculty of Engineering, \ Universitas Muhammadiyah Palembang, Indonesia. | C

Venue: N 403Session Chair: r. an anna

Venue: N 405Session Chair: r. i a en ra hetti

10.00 - 10.30 am T-02r. hitharan an e e

National Institute of Technology Karnataka, Surathkal, IndiaE -

T-03r. aro ini

Department of Industrial Chemistry,Mangalore UniversityT

C

10.30 - 10.45 am Tea break

10.45 - 11.15 am T-04r. N arish

Department of Chemistry, Acharya Institute of Technology, Bangalore, India

T-04r. Nasarul sla

Department of Chemistry, Govt. Degree College, Sopore, IndiaC -

11.15 - 1.00 pm Oral presentations: OP-10 to OP-17

Oral presentations: OP-18 to OP-25

1.15 - 2.00 pm Lunch break (Venue: MIT Food Court)

T S 2

1


Venue: N 403Session Chair: Dr. Nasarul Islam / Dr. M N K Harish

Venue: N 405Session Chair: Mr. Revaiah R G / Dr. Santosh C

2.00 - 2.30 am T-06r. han rashe ar

Aisan Paints Ltd., Research and Technology Centre, Navi Mumbai I

T-07r. enu o ala e

Department of Studies in Chemistry, Vijayanagara Sri Krishnadevaraya University, Ballari C

- -

2.30 - 3.00 am T-08r. Arun sloor

Dept. of Chemistry, National Institute of Technology Karnataka, Mangalore Ne eneration ol er

e ranes or ater uri i ation an esalination

a li ation

T-09r. an anna

Dept. of Chemistry, Rani Channamma University,Belagavi, Karnataka

3.00 - 4.30 pm Poster presentations: PP-31 to PP-106

4.30 - 4.45 pm Tea break

4.45 - 6.00 pm Campus tour

Te hni al session

2


Day: 03 16-09-2017

Ti e ent

8.00 - 9.00 am Breakfast

Venue: ir . . all A a e i lo -2

Te hni al session -

Session Chair: r. arish u ar

9.00 - 9.45 am T-0 r. Pra een Department of Chemistry, Srinivas School of Engineering, Karnataka. S

9.45 - 10.05 am IT-10 r. othi Department of Chemistry, St Joseph Engineering College, .Vamanjoor, Mangaluru. S

10.05 - 10.25 am IT-11 r. i a en ra hetti Department of Chemistry, BMS College of Engineering, Bangalore.

10.25 -10.45 am IT-12 Department of Chemistry, I I T E -

10.45 – 11.00 am Tea break

11.00 – 12.00 pm Oral presentations: OP-26 to OP-30

12.00 - 12.30 pm Poster sessions: PP-61 onwards

12.30 – 2.00 pm Lunch (Venue: MIT Food Court)

2.00 - 3.00 pm Valedictory Ceremony

3.00 pm High Tea

3

Oral Presentations

ICETCS-2017

4

Presentation No. Author/Presenter Title

OP-01 Rajalakshmi K. Molecular design and synthesis of metal free

diphenylamine based sensitizer for dye sensitized

solar cells

OP-02 Harisha. S A new rapid, convenient and eco-friendly method for the

synthesis of 5-amino-1,3,4-thiadiazole-2-thiol based

heterocyclic azo dyes by using different catalysts –

A Green Protocol

OP-03 MS Yogendra Kumar Determination of the dyeing method of flame retardant

aramid technical textiles using DSC Microscope

OP-04 J.Mamatha Development and validation of RP-HPLC method for the

analysis of Rimantadine Hydrochloride in pure form.

OP-05 Channamma M Evaluation of anti-inflammatory activity of some novel

benzofuranpyrimidine derivatives

OP-06 Gaurav Rattan Synthesis, characterization and effect of catalytic activity on

supported Co-Ce catalyst for CO oxidation

OP-07 Viprabha K A thiophene derivative for application in optoelectronic

devices

OP-08 Majalkere Design and synthesis of novel aryl substituted

Krishnakishore thiazolidinone derivatives by suzuki coupling for

anticancer activity

OP-09 Ammembal Jaya Pai Spectral and morphological studies on bischalcone doped

polylactic acid (PLA) thin films for optoelectronics

applications Synthesis, characterization and study of new

thiazole -2-amine derivative as corrosion inhibitors for mild

steel in 0.5 M H2SO4 solution

OP-10 Momumitha establishing sructure property relationship in drug

Dasgupta partitioning into and release from niosomes: physical

chemistry insights with anti-inflammatory drugs

OP-11 S.Shalini Crystal structure analysis and bioactivity of

N-(5-methylsalicylidene)aniline

OP-12 M. Gururaj Acharya Electrochemical and corrosion studies of az31 magnesium

alloy in chloride and sulphate medium

OP-13 Aranganathan Amelioration of the electrochemical performances of the

Viswanathan reduced graphene oxide/ nickel oxide/ polyaniline

nanocomposite by combination of electrolytes

OP-14 Nandini R Polyelectrolyte-dye interactions: effect of dye structure

on metachromasy

OP-15 Vivek Ghate M Brain delivery of a model hydrophilic drug using

amino acid grafted chitosan nanoparticles

OP-16 Eswara Rao Thermodynamic analysis of c1 – c6 molecules

aromotization under non-oxidative conditions

OP-17 G. Darabdhara Magnetically recoverable core-shell Au@Ni/rGO

nanocomposites as active photocatalyst for the

degradation of organic compounds under natural

sunlight irradiation

5


OP-18 Vignesh U. N Synthesis of new series of isoniazid derivatives and their

biological evaluation against Mycobacterium tuberculosis

in mgit liquid culuture

OP-19 J. Sandya Rani Method development and validation of Enzalutamide pure

drug substance by using liquid chromatographic technique

OP-20 Mohammed Temperature dependent reversible dynamics in SinC

Azeezulla Nazrulla (n=3-9) binary nanoclusters: A BOMD study

OP-21 Vineetha Telma Synthesis and characterisation of biologically important

D'Souza (E)- 1-(2-chloro/hydroxy-6/8-substituted quinolin-3-yl)-N-

[5-(4- substitued phenyl)-1,3,4-thiadiazol-2-yl]methanimines

OP-22 Hidayath Ulla Investigation of 2-(4-tert-butylphenyl)-5-(pyren-1-yl)-1,3,4-

oxadiazole as an electron transport material in organic

light-emitting Diodes

OP-23 R G Revaiah Method for qualitative and quantitative analysis of fire

retardant fabric

OP-24 Neelam Keshwani Thermodynamic and spectroscopic studies of interaction of

kanamycin with DNA

OP-25 Reena kumari P.D The corrosion inhibitive effect of eco-friendly green inhibitor

for aluminium 6063 alloy in 0.5 m hydrochloric acid

OP-26 Anil HN Rao Anion exchange membranes based on terminally

crosslinked methyl morpholinium-functionalized

poly(arylene ether sulfone)s

OP-27 Hemanth Hegde Catalyst free synthesis of dihydropyrano pyrazole

derivatives using peg-400

OP-28 N Akshatha Synthesis of maleic anhydride water soluble antimicrobial

polymers for diverse applications

OP-29 Vivekanand Jadhav Amberlyst IR 120 mediated synthesis of diverse

3,4-disubstituted isoxazol-5-(4H)-ones

OP-30 Charitha B.P AlloyPullulan as an ecofriendly green inhibitor

for corrosion control of 6061-al alloy

OP-31 Manjunatha Hegde Synthesis, characterization and study of new thiazole -2-

amine derivative as corrosion inhibitors for mild steel in 0.5

M H2SO4 solution

OP-32 Niveditha N.B Studies on isolation and Biochemical characterization of

collagen from skin of arabian sea fish Sardinella longiceps

OP-33 Suvarna G Kini Novel schiff's bases of substituted 2-amino benzothiazoles

design, synthesis and antimicrobial activity

OP-35 Ajithkumar M P Preparation of fluorescent carbon dots from agro waste


PP-01 Prathima Mathias D.A Fabrication and properties of dye sensitized solar cell from

dye extract from Callindra Haematocephala as sensitizer

PP-02 C.T. Keerthi kumar Synthesis, characterization and biological activity of

4-aminoantipyrine incorporated azo dye

PP-03 Vinod Kumar Synthesis and characterization of azo dyes derived from

2-amino-4-arylthiazole

PP-04 Naveenchandra New cyanopyridne light emitting polymers for

Pilicode pled applications

PP-05 Kabiru Bello Microwave assisted synthesis and characterization of

pH responsive Banana pseudo-stem-g-poly (sodium

acrylate-co-acrylamide) superabsorbent hydrogel

PP-06 Sharath B. O Straightforward synthesis of calcium levulinate from

biomass-derived levulinic acid and calcium carbonate

in egg-shells

PP-07 Meghashree K.S Phytochemical screeningand antimicrobial, antioxidant

activity of leaves extract of Canthium dicoccum

PP-08 Anees Fathima Synthesis, characterization, antimicrobial, antioxidant and

cytotoxicity studies of some benzoxazoles derivatives

PP-09 Shivarudrappa H. P Synthesis and biological evaluation of carbazole and

phenylacetamide hybrids

PP-10 Latha K.P Diabetic activity of holarrhena antidysenterica leaves in

alloxan-induced diabetic rats

PP-11 Harshitha K. R. Green synthesis of α-bromochalcones and 1, 2, 4 –triazolo

[3, 4, - b] thiadiazines derived from them for

cytotoxic activity

PP-12 Masrat Maswal pH Sensitive behavior of composite hydrogels of chitosan

and alginate: characterization and its use in

encapsulation of citral

PP-13 R. Devika Bhai [(Phenyl)-iminomethyl] naphthalene derivatives as novel

bioactive ligands: Antibacterial activity and insilico docking

PP-14 Sudhakar Y N High performance supercapacitor from electrochemically

deposited pt-pani nanomaterials

PP-15 Yuvaraj T.C.M Metal complexes of (N-(3-methoxyphenyl)-2-[(2E)-3-

phenylprop-2-enoyl] hydrazinecarboxamide: Spectral,

thermal, molecular docking and biological studies

PP-16 Sharanya Kuthyala Synthesis, characterization and total antioxidant capacity of

some new imidazopyridine chalcone derivatives

PP-17 Sushobhan Ghosh Design and synthesis of receptor for neurotransmitter

dopamine

Poster Presentations

ICETCS-2017

6


PP-18 Mohammed Synthesis of (4-bromo-3-fluorophenyl)

Shafeeulla R (pyrimidin-5-yl)methanol and their transition metal

complexes; Spectral, XRD, Cytotoxicity, Molecular Docking

and Biological Evaluation

PP-19 Vishwanath T Synthesis, thermal and mechanical studies of chitosan-

acetaldehyde schiff base

PP-20 Anitha Thermo gravimetric study of some bisazo complexes

PP-21 Sareen Sheikh Study of chitosan grafted silk fibre reinforced

pva films for potential biomedical applications

PP-22 Beena B. R Anti-hypertensive guided fractionation of Nardostachys

jatamansi (D. Don)

PP-23 Srikanta S.A Electrochemical reduction of 5-metoxy-5,6-bis

(3-nitrophenyl)-4,5-dihydro-l,2,4-triazine¬3 (2H)-thione on

zinc cathode with surface morphology

PP-24 Meenaketan Sethi Solvothermal synthesis and electrochemical behavior of

nico2o4 nanorods

PP-25 Shyam Sundar. J Preparation of chelated complexes with micronutrients and

characterization using chemical and instrumental methods

PP-26 Dini Ahanthem Csp2-O bond formation via nickel-catalyzed cross-coupling

reaction in water enabled by micellar catalysis

PP-27 Prabhat Ranjan Theoretical study of Ge doped Au nanoalloy clusters:

a density functional study

PP-28 Sneha N kagatikar Corrosion inhibition of stainless steel using benzyl

isothiocynate in acidic medium

PP-29 Nelaturi Subbaiah A selective and sensitive method development and

validation by LC-MS/MS approach for trace level

quantification of two potential genotoxic impurities in

Albendazole drug substance

PP-30 Ayushi Tripathi Derivatives Synthesis and characterization of new series of

thiazolidine-2,4-dione derivatives

PP-31 Sushmithadevi Synthesis and characterisation of pyridine derivatives

PP-32 Swarnagowri Synthesis and evaluation of new series of 3-mercapto-

1, 2, 4-triazole derivatives as antimicrobial agents

PP-33 Neelam Keshwani Thermodynamic and spectroscopic studies of interaction of

kanamycin with DNA

PP-34 Pruthviraj. R. D Electrochemical Studies of Aluminium- Alloy using

Pomagranate as organic Inhibitor

PP-35 Sangeetha Karanth Synthesis and characterization of 2, 5-dioxopyrrolidinyl

acid amide derivatives

7


PP-36 M .Swetha Method development and validation of aegle marmeleous

PP-37 Aminath Rajeena Synthesis, characterization and antioxidant activity of

C.H 1,2,3 triazole carrying novel chalcones

PP-38 Preetha B. K Synthesis of karaya gum grafted 2-(methacryloyloxyethyl)

trimethyl ammonium chloride (KG-graft-METAC) for the

effective removal of anionic dyes

PP-39 Arun Krishna K Pectin based ZnO nanocomposite hydrogel: Evaluation as

adsorbent for divalent metal ions

PP-40 Ritesh Tiwari Solvent-free oxidation of biomass-derived 5-(chloromethyl)

furfural (CMF) into 2,5-Diformylfuran (DFF)

PP-41 N. D. Jayanna Synthesis, characterization, antibacterial and cytotoxic

screening of 2-[(5-methoxy-1-naphthyl) thio]-1,3-

benzoxazole derivatives

PP-42 S. H. Shreedhara Synthesis, in vitro cytotoxic and antibacterial evaluation of

2-(1,3-benzoxazol-2-yl)-2,3-dihydrophthalazine-1,4-dione

derivatives

PP-43 Kumar MD Analgesic and hepatoprotective activity with isolation of a

compound from methanol extract of seeds of kunstleria

keralensis

PP-44 Pavitra Pai Mesomorphic thermal stabilities of di chloro substituted

hydrogen bonded binary mixtures

PP-45 Aiswarya Paul Fluorescent sensor for detection of transition metal ions

in water

PP-46 Deepak Hydrogen bonded complexes of 4-pyridylbenzylidene-4ʹ-

chloroaniline with 4-alkoxybenzoic acids and their

mesomorphic thermal stabilities

PP-47 Santhosh Prabhu Synthesis and characterization of pyrazole-coumarin hybrid

PP-48 Sujay Synthesis and characterisation of some coumarin

schiff bases

PP-49 UwabagiraNadine 2-Anilinothiazole derivatives as inhibitors of penicillin

binding proteins:design, synthesis and characterization

PP-50 K. Vijaya Bhaskar One-pot synthesis of spiro-cyclopropane derivatives and

their biological evaluation

PP-51 Pushpanjali Corrosion inhibition of Curry leaves extract on corrosion

control of aluminum in hydrochloric acid medium

PP-52 Ruchi verma Molecular docking based approach for the design of novel

molecules as inhibitor of beta-hydroxyacyl-acp

dehydratase hadab complex

8


PP-53 Surekha M Conductance study on solvation behaviour of tetrabutyl

ammonium bromide in 2-ethoxy ethanol+water mixtures at

288.15k - 318.15k

PP-54 Sujay M M An investigation on mechanical, wear and morphological

properties of areca leaf fiber-cnt-epoxy and eupatorium

fiber-cnt-epoxy reinforced hybrid polymer composites

PP-55 Atanu Jha Designing of cheap and efficient sponge based

superabsorbent for oil-water separation

PP-56 Pooja R Kamath Synthesis and characterization of some new indole

derivatives for anticancer activity using chitosan

nanoparticles

PP-57 Pavithra K.S Experimental investigation of thermo-physical properties of

CuO/deionized water based nano�uid: Role of dispersants

PP-58 Pooja M Synthesis and antimycobacterial screening of new

chalcone derivatives

PP-59 Krithi K. Bhagavath Targeting Synthesis of novel dihydropyrimidines and their

evaluation for antitubercular activity against Mycobacterium

smigmatis

PP-60 R. Ajithkumar Kinetic, thermodynamic and isotherm studies for the

adsorptive removal of Auramine-O and Cu(II) ions using

AgCl/AC: Optimization and modelling approach using

artificial neural networks

PP-61 Kamballur Kottayil Validated spectrophotometric method for the

Dhanusha determination of metformin hydrochloride by the formation

of charge transfer complex

PP-62 Shalini Udupa Inhibition by Clerodendrum paniculatum leaves extract on

thecorrosion of stainless steel in NaCl medium

PP-63 Prashant B.Hiremath Ultrasound assisted green method for the synthesis of 2-

amino-4H-chromenes using WEPBA

PP-64 Sowmya Single and multilayered supercapacitor electrodes based

on composites of carbon fibre and polyaniline

PP-65 Aparna Prasad Self-assembled discotic liquid crystals

PP-66 Sangeetha D. N Electrochemical performances of nano mos2/activated

carbon supercapacitor

PP-67 J.D.Manohar Synthesis of piperazine derived quaternary ammonium

antimicrobial surfmers

PP-68 Niraj Jasani Biosorption of diazinon pesticide from water by

using nanocellulose

9


PP-69 B. Keerthi Application of response surface methodology (Box-

Behnken Design)for copper adsorption by agro waste

PP-70 A. Jayashree Heterocyclic privileged medicinal scaffolds by a

convergent route using nanocrystalline zno as catalyst

PP-71 Abhishek Shah Docking studies for exploration of potential anti-androgen

activity of 3`, 4`-methylendioxy acetophenone against

Prostate diseases

PP-72 Dilip.H.N Molecular dynamics simulations of amino acids in

co-solvents

PP-73 B Harsha Graphitic carbon nitride incorporated CaTiO3 cuboids as a

photocatalyst

PP-74 Numbury Surendra Theoretical studies of Electronic and Optical properties

Babu for some new Azo disperse dyes for Dye-Sensitized Solar

Cells (DSSCs) by using TD and TD DFT method

PP-75 Akshatha Shetty Study of magnetic field effect on electrodeposition of

Ni-Co alloy for improved corrosion protection

PP-76 Lalitha Simon Cytotoxicity studies of 7-Amino-2-styrylchromone

analogues

PP-77 Lavanya M Study of erosion corrosion on aluminum alloy by

submerged jet impingement technique

PP-78 Shobha Anti-bacterial activity of Synthesized Zinc oxide nano

particles Assisted by Microoven method

PP-79 KB Umesha Novel Isoxazoline-1,2,4-oxadiazoles: Synthesis,

Characterization and Antimicrobial screening

PP-80 M Chandra Shekhar Removal of lead and mercury from wastewater using

Nayak Polyphenylsulfone / multiwalled carbon nanotube

composite ultrafiltration membranes

PP-81 Gouri Shetti Synthesis and characterisation of coumarin

oxadiazole hybrid

PP-82 Nithya R Adsorption of chromium (VI) onto chitosan powder:

Equilibrium, Thermodynamics, Kinetics studies

PP-83 Raviprabha K The corrosion inhibitive effect of 5-(3-pyridyl)-4h-1,2,4-

triazole-3 thiol for aluminium 6061 alloy in various

concentrations of hydrochloric acid

PP-84 Yudhistira B 2-[(1h- imidazole-2-yl) [methylidene] hydrazine

carbothioamide (IMHC) as corrosion inhibitor for mild steel

in phosphoric acid medium

PP-85 N Nagaraja A study on structural, morphological, and chemical

compositional characterzation of soil samples of

chitradurga and shimoga districts.

10

11


PP-86 Ravi BN Synthesis, characterization on 2-aminothiazole based

azo dyes

PP-87 Sarvajith MS Synthesis, Spectral, Magnetic Susceptibility On

Symmetrically Octa Substituted Metal (II)

Phthalocyanines.

PP-88 Shanmuga Priya B Synthesis and antimycobacterial activity of novel

quinazolinone derivatives against Mycobacterium

smigmatis

PP-89 Kashmitha Corrosion inhibition properties of mild steel using 2-

Muthamma (furan-2-ylmethylidene) hydrazine carbothioamide (FMHC)

in 0.5 m HCl medium

PP-90 Ibrahim, A. M A convenient deoximation of oximes by RuO4 catalyzed

oxidation reaction

PP-91 Maliyappa M R Synthesis, Characterization, Solvetochromic and

Biological studies of novel Benzothiazole based azo dyes

PP-92 O. Kotresh Synthesis of benzofuran linked pyrrole derivatives as

anti-cancer agents

PP-93 Manjuraj T Spectral, XRD, thermal, biological and molecular docking

studies of metal complexes containing benzimidazole

moiety

PP-94 Naveen Aradhya S V Metal Complexes of 2-(1,3-benzoxazol-2-yl)-2,3-

dihydrophthalazine-1,4-dione: Spectral, XRD, thermal,

molecular docking and biological evaluation

PP-95 Preethi Kumari Aromatic hydrazide derivative as corrosion inhibitor for

mild steel in hydrochloric acid medium-An electrochemical

approach

PP-96 Karthika Haridas Azodyes synthesis and appraisal of their chromogenic

metal ion sensor applications

PP-97 Apoorva M, Study Of Mesomorphism In The Binary Mixtures of

Di Fluoro Substituted Schiff Base With 4-n-alkyloxy

Benzoic Acids

PP-98 Anoon Nishith Synthesis and chromogenic cation sensing properties of

Chinmayatri some new azodyes

PP-99 B. Chidananda Designing and Spectral Characterization of

Metalphthalocyanines Anchored 3, 5-dihyadroxy-2-

naptanoic based poly(1,3,4-oxadiazole aryl ester)

PP-100 Shivaprasad Shetty Synthesis And Enzyme Inhibition studies of some

Coumarin Derivatives


PP-101 Malathesh pari Cyclic Voltammetric study of 3 ,5- dinitro toluic acid and

3,5- dinitrophthalic acid at glassy carbon electrode

PP-102 Mussuvir Pasha K M Synthesis, Characterization and Spectroscopic evidence

of formation of isomers of 4, 8-dimethyl-2, 6-diphenyl

-1, 5-dihydro-s-indacene

PP-103 Veena.V Anti-neoplastic activity of newly synthesized nano-particles

PP-104 Divyaraj Puthran A facile and practicle one-pot synthesis of

2-[(methylselenyl)methyl]benzoic acid

PP-105 Shukla Modelling of Lead Adsorption from aqueous solutions by

Chamanagowda Patil coir pith and peanut shell using Response Surface

Methodology

Vrunda R Screening of Bacteria with Lipolytic Activity from Soil for PP-106

Industrial Use

12

Development of small-molecule targeting JAK-STA3, and NF-kB in hepatocellular carcinoma

Prof. Rangappa K S

Distinguished Professor, (Former Vice-Chancellor of Univ. of Mysore and KSOU), University of Mysore, IOE Bhavan, Mysuru-570006, India.

E-mail: [email protected]

Keynote - 1

13

ICETC

S-201

7'Drug discovery' has historically been based on phenotypic readouts on the organism level, such as the

effect of herbs or other natural remedies on humans. The increased availability of large-scale

open-access resources on bioactivities of small molecules has a significant impact on pharmacology

facilitated mainly by computational approaches that digest the vast amounts of data. In my talk, I will

combine the machine-learning tools, chemical synthesis, and biological studies to develop small-molecule

targeting JAK2 and NF-kB in hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is the fifth most

common malignant tumor worldwide, and is the third most common cause of cancer related death.

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates genes

involved in cell growth, proliferation, and survival, and given its association with many types of cancers, it has

recently emerged as a promising target for therapy. we present the synthesis of N-substituted azaspirane

derivatives and their biological evaluation against hepatocellular carcinoma, thereby identifying 2-(1-(4-(2-

cyanophenyl)1-benzyl-1H-indol-3-yl)-5-(4-methoxy-phenyl)-1-oxa-3-azaspiro(5,5) undecane (CIMO) as a

potent inhibitor of the JAK-STAT pathway with selectivity over normal LO2 cells. The lead compound, CIMO,

suppresses proliferation of HCC cells and achieves this effect by reducing both constitutive and inducible

phosphorylation of JAK1, JAK2, and STAT3. Interestingly, CIMO displayed inhibition of Tyr-705

phosphorylation, which is required for nuclear translocation of STAT3, but it has no effect on Ser-727

phosphorylation. CIMO accumulates cancer cells in the sub-G1 phase and decreases STAT3 in the nucleus

and thereby causes down-regulation of genes regulated via STAT3. Suppression of STAT3 phosphorylation

by CIMO and knockdown of STAT3 mRNA using siRNA transfection displayed a similar effect on the viability

of HCC cells. Furthermore, CIMO significantly decreased the tumor development in an orthotopic HCC

mouse model through the modulation of phospho-STAT3, Ki-67, and cleaved caspase-3 in tumor tissues.

Thus, CIMO represents a chemically novel and biologically in vitro and in vivo validated compound, which

targets the JAK-STAT pathway as a potential cancer treatment.

Constitutive activation of NF-�B is the underlying mechanism behind tumorigenesis and this protein

regulates the expression of genes involved in proliferation, survival, drug resistance, angiogenesis and

metastasis. The design of inhibitors which suppress NF-�B activation is therefore of great therapeutic

importance in the treatment of HCC. In this study, we investigated the effect of newly synthesized coumarin

derivatives against HCC cells, and identified (7-Carbethoxyamino-2-oxo-2H-chromen-4-

yl)methylpyrrolidine-1 carbodithioate (CPP) as lead compound. Further, we evaluated the effect of CPP on

the DNA binding ability of NF-�B, CXCL12-induced cell migration and invasion, and the regulated gene

products in HCC cells. We found that CPP induced cytotoxicity in three HCC cells in a time and dose

dependent manner, and suppressed the DNA binding ability of NF-�B. CPP significantly decreased the

CXCL12-induced cell migration and invasion. More evidently, CPP inhibits the expression of NF-�B targeted

genes such as cyclin D1, Bcl-2, survivin, MMP12 and C-Myc. Furthermore, the molecular docking analysis

suggested that CPP interacts with the p50 binding domain of the p65 subunit, scoring best among the 26

docked coumarin derivatives of this study. Thus, we are reporting CPP as a potent inhibitor of the pro-

inflammatory pathway in Hepatocellular carcinoma.

Liquid Crystals: The Intriguing Fourth State of Matter

Sandeep Kumar

Raman Research Institute, C.V. Raman Avenue, Bangalore - 560 080, IndiaE-mail: [email protected]

Keynote - 2

Life on Earth begins with the self-organization of molecules. No life would be possible without the self-

assembly of lipids into bilayers within the cell membrane. Numerous biological supramolecular structures

result from self-assembly of organic molecules. In materials science, non-covalent interactions have been

used to obtain well-defined self-assembled architectures in neat systems as well as in solvents. Liquid

crystals (LCs) belong to one of such systems. Supramolecular interactions such as van der Waals forces,

dipolar or quadrupolar interactions, charge-transfer interactions and hydrogen bonding play a crucial role in

the formation of LCs and in the determination of their mesomorphic properties. Liquid crystalline state - the

fascinating, intriguing, beautiful, mysterious, delicate fourth state of matter, is an intermediate state between

the solid and the liquid. Liquid crystals are unique nanostructures with remarkable electronic and

optoelectronic properties. They combine both the fluidity of liquids and the anisotropy of crystals. These

materials are extremely diverse since they range from DNA to high strength synthetic polymer like Kevlare

and from small organic molecules used in display devices to self-assembling amphiphilic soap molecules.

Although LCs have diverse applications such as temperature-sensing (medical thermometers), solvent in

chemical reactions, in chromatography, in spectroscopy, in holography, etc., they are primarily known for

their extensive exploitation in electrooptical display devices such as watches, calculators, telephones,

personal organizers, laptop computers, etc.

This lecture will give an elementary knowledge of liquid crystals, their history, classification, synthesis and

characterization using polarizing optical microscopy, differential scanning calorimetry and X-ray diffraction.

A brief idea of liquid crystal display, their construction and working will be presented. LCs in thermal sensors

and the concept of “writing with light” will be described. Finally, some aspects of discotic liquid crystal

nanocomposites and their applications will be discussed

14

ICET

computers,

ICET

computers,

elementary

ICET

elementary knowledge

ICET

knowledge

polarizing

ICETpolarizing optical

ICEToptical microscopy

ICETmicroscopy

display

ICETdisplay,

ICET, their

ICETtheir construction

ICETconstruction

“writing

ICET“writing with

ICETwith light”

ICETlight” will

ICETwill be

ICETbe

and

ICET

and their

ICET

their applications

ICET

applications will

ICET

will

Cspectroscopy

Cspectroscopy

electrooptical

Celectrooptical display

Cdisplay

etc.

Cetc.

knowledge Cknowledge of Cof liquid Cliquid

microscopyCmicroscopy

Sdevices

Sdevices

temperature-sensing

Stemperature-sensing

spectroscopySspectroscopy, S, in Sin holographySholography

devices Sdevices such Ssuch

-201

7interactions

-201

7interactions

well

-201

7well as

-201

7as in

-201

7in solvents.

-201

7solvents.

crystals (LCs) belong to one of such systems. Supramolecular interactions such as van der W

-201

7crystals (LCs) belong to one of such systems. Supramolecular interactions such as van der Waals forces,

-201

7aals forces, crystals (LCs) belong to one of such systems. Supramolecular interactions such as van der Waals forces, crystals (LCs) belong to one of such systems. Supramolecular interactions such as van der W

-201

7crystals (LCs) belong to one of such systems. Supramolecular interactions such as van der Waals forces, crystals (LCs) belong to one of such systems. Supramolecular interactions such as van der W

hydrogen

-201

7hydrogen bonding

-201

7bonding play

-201

7play a

-201

7a crucial

-201

7crucial

properties.

-201

7properties. Liquid

-201

7Liquid crystalline

-201

7crystalline

matter

-201

7matter,

-201

7, is

-201

7is an

-201

7an intermediate

-201

7intermediate

nanostructures

-201

7nanostructures with

-201

7with remarkable

-201

7remarkable

liquids

-201

7liquids and

-201

7and the

-201

7the anisotropy

-201

7anisotropy

DNA

-201

7DNA to

-201

7to high

-201

7high strength

-201

7strength synthetic

-201

7synthetic

to -201

7to self -2

017

self-assembling -201

7-assembling

temperature-sensing -201

7

temperature-sensing

holography-2

017

holography

Protective Equipment for a fighter pilot – Stresses and solutionsDr T M Kotresh

Distinguished Professor, (Former Vice-Chancellor of Univ. of Mysore and KSOU), University of Mysore, IOE Bhavan, Mysuru-570006, India.


The military warfare environment continues to increase in its complexity with the technological advances in

the fields of materials, communication, sensors, leading to the introduction of lean-mean fighting machines,

improved weapons, and lethal chemical and biological agents. Adding to this complexity is the battle field

environment that includes the open skies, mountainous high altitudes on one hand and the depths of

oceans on the other hand, apart from the hot-dry deserts, hot-humid areas and cold to extreme cold regions.

India being a vast country, the battle field environment is varied and involves cold to extreme cold in

Himalayan ranges, temperate to hot in central region, hot dry in desert areas and hot humid in eastern

region. The designer has therefore a challenging task in designing equipment suitable for use under a wide

range of climatic variations. The environment and the technological advances subject the troops to

physiologically hostile stresses thereby severely restricting their performance. The physiologically hostile

stresses that the troops face highlight the requirement of Life Support System and protective equipment to

maintain the troops in battle fit condition and to accomplish the mission on hand. There can be no single life

support system and protective equipment that can provide a utopian solution as the design and

development of life support system and protective equipment is governed by the type of stresses

encountered by the troops. The stresses encountered by a fighter pilot flying a military aircraft are entirely

different from the stresses encountered by a free-fall combat paratrooper jumping from the altitudes of

30,000 ft or a submarine crew escaping from an abandoned submarine from the depth of 100 m.

The military flying environment is a high risk environment and rich in potential stressors such as temperature,

acceleration, noise and communication, decompression sickness, vibration, hypoxia, exhaust fumes and

motion sickness. Obviously, all these environmental stressors affect the fighter pilot and may lead to

compromise in the accomplishment of the mission on hand, in the absence of suitable protective

equipment. Another aspect, though not a stress factor, that need to be considered is the flammability aspect

in the event of any protective equipment involves the use of textiles as in the case of pilot's clothing.

Necessary attention has to be paid to the clothing that the pilot wears as it will have direct bearing on the

chances of survival in the unlikely event of fire, and the heat stress. The threat of fire is ever present with every

take-off, landing or in-flight. As the temperatures in a crash fire can reach up to 1200o C in about 20 seconds

time, there is a need to provide the pilot with flame retardant clothing that greatly enhances the chances of

saving the life of a pilot.

Design and development of protective equipment for armed forces is surely the most demanding technical

challenge undertaken by DRDO, and requires close collaboration among engineers, physicists,

physiologists, aviation medicine specialists, and professionals with a variety of other skills. As the topic of

aeromedical protective equipment and flying clothing is very vast, the present talk is restricted to the design

and development of aeromedical protective equipment undertaken by DEBEL for ameliorating the stresses

faced by aircrew flying fighter aircrafts. The talk attempts to highlight the stresses, measures to counter the

stresses, and design and development of indigenous protective equipment to suit the requirements of

fighter pilots.

T

PT-01

15

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in

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accomplish

Saccomplish the

Sthe

can Scan provide Sprovide

protective Sprotective equipment Sequipment

-201

7technological

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7technological

lean-mean

-201

7lean-mean fighting

-201

7fighting

complexity

-201

7complexity is

-201

7is the

-201

7the

one

-201

7one hand

-201

7hand and

-201

7and the

-201

7the depths

-201

7depths

and

-201

7and cold

-201

7cold to

-201

7to extreme

-201

7extreme cold

-201

7cold

and

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7and involves

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7involves cold

-201

7cold to

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7to extreme

-201

7extreme

desert

-201

7desert areas

-201

7areas and

-201

7and hot

-201

7hot

designing

-201

7designing equipment

-201

7equipment suitable

-201

7suitable

technological

-201

7technological advances

-201

7advances

restricting -201

7restricting their -2

017

their performance. -201

7performance.

Life -201

7Life Support -2

017

Support System -201

7System

mission -201

7

mission

Correlation between morphological and permeability fraction of composite membrane on textile wastewater treatment

a,b, b,cE. Yuliwati *, K.A. Ronia, N. Herawatia, Ahmad Fauzi ismail

aDepartment of Chemical Engineering, Universitas Muhammadiyah Palembang, Indonesia. Tel. +62 (711) 513-022

bAdvanced Membrane Technology Research Centre (AMTEC), cFaculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Malaysia

Tel. +60 (7) 553-5592

PT-02

In this study, a high performance composite membrane has been prepared for treating of textile wastewater.

Microporous hydrophobic membranes for coolant wastewater have been extensively reviewed. Many

investigations attempted the use of polyvinylidene fluoride (PVDF) hollow fiber membranes to separate the

organic matter in textile wastewater. The composite PVDF membrane was produced by adding organic and

inorganic materials in order to obtain a functionalized polymer which is suitable for preparing of membranes

with improved the hydrophilicity and fouling resistance. Moreover, PVDF membranes were found to be an

effective membrane material for textile wastewater treatment due to increase the flux and fouling resistant

ability. By understanding the available methods, one can choose and optimize the best technique during

fabrication of developed PVDF membranes. Furthermore, areas of future potential in the textile wastewater

treatment research were also identified. Hollow fibers were spun from a dope solution containing PVDF/PVP

30K/DMAc/ additives(s) by using a dry-jet wet spinning process at different air gaps. To enhance the

antifouling properties of membranes, 2 wt.% inorganic titanium oxide (TiO2) has been added into dope

during polymeric solution preparation. Characterization of the membrane in terms of pure water, molecular

weight cut off (MWCO), and retention for a model coolant wastewater were conducted, and the fouling

resistance was analyzed. The pure water permeation flux and MWCO increased with the increase of air gap,

however, significantly decreased the retention for coolant wastewater. The PVDF/TiO2 best membrane had

a pure water flux of 92.8 L/m2.hr and a nominal MWCO of 61 kDa with retention rate of over 91%. From

FESEM study, PVDF/TiO2 composite membranes exhibited a quite symmetric cross-section structure

containing four layers when the air gap distance was varied from 0 to 7 cm. Two small finger-like structure

layers at the edges of the hollow fibers and two larger finger-like voids mixed with macrovoids layers in the

middle cross-section. If there is an air gap before coagulation, the effects of elongation and relaxation will

play important roles due to stress affects dramatically the polymer molecular orientation and relaxation at the

outer surface. In this research, it was believed that the elongation stress caused by gravity becomes more

pronounced with increasing air gap and this may diminish the surface roughness. This due to the molecular

orientation induced by shear stress within the spinneret might relax in the air gap region if the elongation

stress along the spin line is small as spinning solution is viscoelastic fluid or enhance if the spin line stress is

high. This is reflected in the decrease of the roughness parameters on the outer surface with an increase in

air gap length. As occurred for the roughness, AFM image analyses demonstrated that wet spun hollow

fiber had a rougher outer surface than that of dry-jet wet spun fibers which can be attributed to the die swell,

which was occurred during extrusion of viscous dope. The PWP flux was not proportional to the mean

roughness of the external surface but higher water permeation and lower solute separation were observed

for composite membranes with lower mean external roughness. The PVDF membrane hydrophilicity and

surface wettability were enhanced because the introduction of TiO2 particles in this study performed a much

lower fouling tendency than the naked PVDF membrane. Significantly, the tensile mechanical strength of

membrane was also enhanced by the addition TiO2 addition. Therefore, PVDF/TiO2 in this study exhibited a

better performance that resulted a much lower fouling tendency than the naked membrane.

16

ICET

water

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water

the

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retention

L/m2.hr

ICETL/m2.hr and

ICETand a

ICETa nominal

ICETnominal

composite

ICETcomposite membranes

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of

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of the

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the hollow

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hollow fibers

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and


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important

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this research,

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CCharacterization

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Cmodel coolant

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retention Cretention for Cfor coolant Ccoolant

nominal Cnominal MWCO CMWCO

Swere

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inorganic

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Characterization SCharacterization of Sof the Sthe membrane Smembrane

coolant Scoolant wastewater Swastewater

and Sand

-201

7of

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7of textile

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extensively

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7extensively reviewed.

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membranes

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7to separate

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produced

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suitable

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PVDF

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7PVDF membranes

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7were

effective membrane material for textile wastewater treatment due to increase the flux and fouling resistant

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7effective membrane material for textile wastewater treatment due to increase the flux and fouling resistant

choose

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7and optimize

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7optimize the

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7the

areas

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7areas of

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7of future

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7potential

were -201

7were spun -2

017

spun from -201

7from a -2

017

a dope -201

7dope

process -201

7process at -2

017

at different -201

7different

titanium -201

7

titanium oxide -201

7

oxide

Pulse Electrodeposition, characterization and corrosion behavior of Ni–Si3N4 composites

Dr. Praveen B MaDepartment of Chemistry, Srinivas School of Engineering, Karnataka, India.

E-mail: [email protected], 919980951074

PT-03

The Ni–Si3N4 composites were generated by the Pulse electrodeposition method. Operating variables

were optimised for getting a good deposit. The amount of Si3N4 particles in the coating were analysed by an

energy dispersive x-ray diffraction (EDAX) spectrometer. X-ray diffraction (XRD) and scanning electron

microscopy (SEM) were used to analyse the structure and surface morphology of the coatings. Texture

coefficient and hardness of the deposits were determined and discussed. The corrosion behaviour of the

bare Ni and its composite coatings were analyzed by traditional weight loss method and electrochemical

methods. Comparisons of the corrosion behaviour of coatings obtained by direct current electrodepsoition

(DC) and with Pulse electrodeposition method (PC) were investigated.

Drug-development is the most challenging foot-step in modern drug discovery process. After finding the

therapeutic efficacy of a drug or drug candidate successful implementation depends on the right

developmental team work among chemists, biologists, bioinformatics, and medical doctors. However,

therapeutic efficacy of a drug depends on its ability to overcome the biological barriers and reach the desired

tissue and intracellular target sites. The biological barriers includes, for example cellular plasma

membranes, blood-brain barriers (BBB), and nuclear membranes. It is generally known that the plasma

membrane allows entrance only those molecules with an appropriate range of molecular size, polarity, and

charge. Therefore, many well developed drug with promising in vitro activities fail to come up as a successful

pharmaceutical agents. Therefore the production of suitable drug delivery vehicle or molecular transporters

to overcome the biological barriers would highly desirable in drug development. In this context, a number of

cell-penetrating peptides (CPPs) derived from HIV-1 Tat protein have been extensively studied to improve

the absorption, distribution, metabolism and elimination (ADME) properties of poorly bio available drugs

including small molecules. Drug delivery system particularly targeted drug delivery vector development

towards diseased cells or tissues is an important and attractive area in biomedical of research. Next,

exploration of a sensitive diagnostic nanoprobe especially towards the aim of point of care treatment is

another challenging task for early and accurate detection of diseases which facilitates efficacious therapy

and monitoring of therapeutic progression to reduce mortality and morbidity. In this regard, optical imaging

technologies using nanomaterials such as gold or silver nanoparticles, iron oxide nanocrystals and

quantum dots have successfully been applied for molecular diagnosis, in vivo imaging and drug delivery. In

recent years, surface-enhanced Raman scattering (SERS) technology invented to be most sensitive

techniques among other optical imaging modalities as the signal intensity of molecular vibration enhanced

108 –1014 folds compare to simple Raman spectra. Our group has revealed a systematic and

comprehensive screening and selection process to identify ultra sensitive and potential multiplexing-

capable novel SERS nanotags for in vitro and in vivo imaging. As a practical application of the novel probes,

we have successfully demonstrated by targeting specific cancer biomarkers e.g. EGFR and Her2, which are

important candidates for cancer detection and therapy, e.g. breast, lung and cervical and prostate.

17

ICET

challenging

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challenging

or

ICETor drug

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drug candidate

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candidate

among

ICETamong chemists,

ICETchemists, biologists,

ICETbiologists,

drug

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ICEThe

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blood-brain

ICETblood-brain barriers

ICETbarriers (BBB),

ICET(BBB), and

ICETand

entrance

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entrance only

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only those

ICETthose molecules

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molecules

Therefore,

ICET

Therefore, many

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many well

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well developed

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developed

pharmaceutical

ICET

pharmaceutical agents.

ICET

agents. Therefore

ICET

Therefore

overcome

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overcome the

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the biological

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biological barriers

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barriers

cell-penetrating ICET

cell-penetrating peptides ICET

peptides (CPP ICET

(CPP

absorption, ICET

absorption, distribution, ICET

distribution,

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small molecules. ICET

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Cchallenging Cchallenging footCfoot-step C-step in Cin modern Cmodern

candidate Ccandidate successful Csuccessful

biologists, Cbiologists,

ability C

ability

S-201

7the

-201

7the coatings.

-201

7coatings.

corrosion

-201

7corrosion behaviour

-201

7behaviour

method

-201

7method and

-201

7and electrochemical

-201

7electrochemical

direct

-201

7direct current

-201

7current electrodepsoition

-201

7electrodepsoition

Emerging Trends in Targeted Drug-Delivery System (TDDS), Diagnostic and Theranostic Nanoprobe for Cancer Treatment

IT-01

Dr. Kaustabh Kumar Maiti

Senior Scientist, Chemical Science & Technology Division, CSIR-NIIST, Trivandrum, Kerala

I T

A. Chitharanjan Hegde

Electrochemistry Research Lab, Department of ChemistryNational Institute of Technology Karnataka, Surathkal, Karnataka, India

E-mail: [email protected], Phone: 0824 - 2473201 (O), Mobile: 9980360242

Materials with ultra-fine microstructure are emerging as new generation materials. Among such group of

materials, a class of materials commonly known composition modulated multilayer (CMM) materials has

drawn the attention of scientific community. The CMM materials basically consist of a very thin layers of

different metals/alloys arranged in alternate fashion. They show remarkable and sometime unique

functional properties not attainable in normal metallurgical alloys. The multilayer coatings can be electro-

fabricated from an electrolyte solution by different approaches, like by pulsing of current density (pulsed

current method), the magnetic field intensity (magneto-electrodeposition), or ultrasound power density

(sonoelectrodeposition), parallel to the process of deposition. It is well known that superimposition of

electric field/magnetic field/ultrasound field intensity, during deposition has large effect on the properties of

coatings, such as nucleation, growth, texture, phase composition, macro-stresses, hardness, morphology,

current efficiency, and preferred orientation, confirmed by different experimental methods. When these

fields, i.e., electric/magnetic/ultrasound fields are pulsed periodically, the coatings are developed in

multilayers with distinct interface; and they observed to have unusually better corrosion resistance and

electro-catalytic properties, compared to its conventional monolayer coatings. The better properties of

multilayer coatings are attributed to the formation of interfaces, affected due to pulsing of fields, confirmed

by scanning electron microscopy (SEM) and X-ray diffraction (XRD) study. The experimental results

investigation will be discussed with the greater insight into the development of multilayer coatings by simple

pulsing of field effects, and their applications in different fields of corrosion control and water splitting.

Prof. B K Sarojini

Professor & Chairperson, Department of Industrial Chemistry,Coordinator, M.Sc., in Biochemistry Programme, Mangalore University, Karnataka, India

E-mail: [email protected]; [email protected] Mob: +91 9886273404 Off: +91 824 2287847

Heterocyclic compounds are major class of organic chemistry and are powerful pharmacophores

for potent and selective drugs in pharmaceutical evaluations. Incorporation of five membered

heterocyclic scaffolds is fascinating strategy in the eyes of medicinal chemists to improve the

activity of potential therapeutic molecules. Among nitrogen and sulfur containing heterocycles,

thiazoles have attracted a special status due to their easy synthetic methods and broad spectrum

of industrial applications. Thiazoles are important class of potent biologically active molecules and

an interesting building block in variety of natural products. A large number of thiazole derivatives

are prepared using different synthetic methods. A popular synthetic method is based on the

Hantzsch condensation reaction of 2-bromoacetophenones with thiourea or selenourea. Due to

their medicinal actions they exhibit predominant role in pharmaceutical chemistry such as

IT-02Electro-fabrication of nanostructure materials and their applications

IT-03Thiazole scaffold a versatile pharmacophore:

chemistry and antimicrobial activity

18

ICET

(SEM)

ICET

(SEM)

the

ICET

the greater

ICET

greater

applications

ICET

applications in

ICET

in

ICET

Professor & Chairperson, Department of Industrial Chemistry

ICET

Professor & Chairperson, Department of Industrial ChemistryCoordinator

ICET

Coordinator, M.Sc., in Biochemistry Programme, Mangalore University

ICET

, M.Sc., in Biochemistry Programme, Mangalore UniversityE-mail: [email protected]; [email protected] ICET

E-mail: [email protected]; [email protected] ICET

compounds ICET

compounds

Thiazole scaffold a versatile pharmacophore:

ICETThiazole scaffold a versatile pharmacophore:


ICET


Cconventional

Cconventional

formation

Cformation of

Cof

(SEM)

C(SEM) and

Cand X

CX-ray

C-ray X-ray X

CX-ray X

Cdiffraction

Cdiffraction

greater Cgreater insight Cinsight into Cinto

in Cin different Cdifferent

Spulsed

Spulsed

Sobserved

Sobserved to

Sto have

Shave

conventional Sconventional monolayer Smonolayer

interfaces, Sinterfaces, Sdiffraction Sdiffraction

-201

7a

-201

7a very

-201

7very

and

-201

7and sometime

-201

7sometime

multilayer

-201

7multilayer coatings

-201

7coatings can

-201

7can be

-201

7be

pulsing

-201

7pulsing of

-201

7of current

-201

7current density

-201

7density

(magneto-electrodeposition),

-201

7(magneto-electrodeposition), or

-201

7or ultrasound

-201

7ultrasound

is

-201

7is well

-201

7well known

-201

7known that

-201

7that superimposition

-201

7superimposition

deposition

-201

7deposition has

-201

7has large

-201

7large effect

-201

7effect

composition,

-201

7composition, macro-stresses,

-201

7macro-stresses,

by

-201

7by different

-201

7different experimental

-201

7experimental

pulsed -201

7pulsed periodically-2

017

periodically-201

7, -201

7, the -201

7the

have -201

7have unusually -2

017

unusually

monolayer -201

7

monolayer

Increasing energy consumption, faster depletion of fossil fuels and increased greenhouse

emissions has triggered scientist around the world to tap energy from wide variety of alternative

sources to move the world toward sustainability. Worldwide enormous efforts have been put to

develop durable and economical fuel producing photocatalysts and increasing the efficiency of

photovoltaic and dye sensitized solar cells. From the context of energy storage, metal-ion

batteries, which currently dominate the battery market, take a long time to charge, can overheat

and catch fire if they are defective or damaged. Further, the usage of Li-based batteries pollutes the

ecosystem severely. Now to drive battery power safely, a brand-new way for power production has

been developed - "Aqueous Chemically Chargeable Photo Battery". Wherein light is used to

actuate discharge chemistry in the cathode of an aqueous rechargeable battery. The proposed

photo battery consists of a titanium nitride photoanode, promising cathode material iron(III)

hexacyanoferrate(II) as the battery active species. Further, an unprecedented means for charging

the battery rapidly is presented using Na2S2O8 and it revitalized the battery in 30 s without any

external bias. This methodology is free from dissolution of active materials, irreversible structural

changes, spontaneous deinsertion reactions, and safety concerns commonly encountered in

present batteries. Apart from bringing out a sustainable way for power production, this device

opens up avenues for charging the battery in the likely events of electrical input unavailability, while

solving the critical issues of longer charging time and higher charging voltage.

sulfathiazol (antimicrobial), ritonavir (antiretroviral), tiazofurin (antineoplastic), meloxicam (anti-

inflammatory), epothilone (anticancer) and abafungin (antifungal) are some thiazole based potent

drugs. Numerous studies demonstrated that, some thiazole derivatives are used as analgesics,

anti-inflammatory, anticancer, anti-HIV, antimicrobial, antimycobacterial antioxidant, antiallergic

agents, anticonvulsants, antifungal and antiprotozoal agents. Also, these thiazole derivatives

found applications in dyes, agrochemicals, biological stain, nonlinear optics and

electroluminescent materials.

As a part of ongoing research on the design and synthesis of potent thiazole molecules with

antimicrobial property, a diverse series of thiazole derivatives are synthesized through different

pathways and evaluated for their prominent properties against multidrug resistant pathogens. The

single crystal X-ray diffraction studies, prediction of intermolecular contacts and distribution of

electrostatic potential of molecular crystal structure was performed by Hirshfeld surface analysis

with 2D finger plots and electrostatic potential map. Also, the interaction of target thiazoles with

protein/enzymes is predicted by molecular docking studies.

19

ICET

consumption,

ICET

consumption, faster

ICET

faster


ICET


world

ICETworld toward

ICETtoward sustainability

ICETsustainability

economical

ICETeconomical fuel

ICETfuel producing

ICETproducing

dye

ICET

dye sensitized

ICET

sensitized solar

ICET

solar


ICET


fire

ICET

fire if

ICET

if they

ICET

they are

ICET

are defective

ICET

defective

ecosystem

ICET

ecosystem severely

ICET

severely.

ICET

. Now

ICET

Now to

ICET

to

developed ICET

developed - ICET

- "Aqueous ICET

"Aqueous

discharge ICET

discharge chemistry ICET

chemistry

consists IC

ET

consists

Cfaster Cfaster depletion Cdepletion

emissions has triggered scientist around the world to tap energy from wide variety of alternative Cemissions has triggered scientist around the world to tap energy from wide variety of alternative

sustainabilityCsustainability

S-201

7thiazole

-201

7thiazole molecules

-201

7molecules

synthesized

-201

7synthesized through

-201

7through

multidrug

-201

7multidrug resistant

-201

7resistant pathogens.

-201

7pathogens.

intermolecular

-201

7intermolecular contacts

-201

7contacts and

-201

7and distribution

-201

7distribution

performed

-201

7performed by

-201

7by Hirshfeld

-201

7Hirshfeld surface

-201

7surface

the

-201

7the interaction

-201

7interaction of

-201

7of target

-201

7target

studies.

-201

7studies.

IT-04Hybrid Photo Battery

Dr. Harish M. N. K.

Assistant Professor, Department of Chemistry, Acharya Institute of Technology,Soldevanahalli, Bangalore-560107, India

Flow behaviors of the paints and coatings are of prime importance during the application on surfaces. Since

the composition of the paint is so complex, the contribution of individual components is considerably high to

the flow behaviors. Pigment dispersions are added to the base paints to obtain the desired color. Substantial

quantity of dispersing/wetting agents are necessary in dispersing and stabilizing the pigment particles. The

chemistry and quantity of the dispersing agents play a crucial role in controlling the stability, flow behaviors

of the dispersions [1, 2].

Here we will present rheological behavior of iron oxide pigment dispersions. The pigment dispersions were

prepared by using various combinations of dispersing/wetting agents. Few trials resulted in very high

viscosity, settling/sticky behaviors after the accelerated stability. The influence of various dispersing agents

on the stability of pigment dispersions will be discussed based on the rheology profiles and visual inspection

of the natural and accelerated samples.

Dr. Nasarul Islam

Department of Chemistry, Govt. Degree College (Boys) Sopore, India- 193201 [email protected]

IT-05Computational studies on hot-cold charge transfer state flip in

triarylamine helicenes derivatives

The geometries, opto-electronic properties and dependence of charge transfer states on interfacial

geometry of triarylamine helicene derivatives (TAH) with donor and acceptor groups have been investigated

at the molecular levels using Density Functional Theory. Calculations on ground state geometries including

neutral, anionic and cationic along with their excited state geometry were carried by using CAM-B3LYP

functional in conjugation with 6-311++G (2d,p) basis set by employing Gaussian 09, DUSHIN and

Schrödinger computational packages. The effect of deviations from the equilibrium geometry on energies

is calculated from first-principles. DFT calculations reveal that TAH derivatives possess low-lying frontier

molecular energy levels, higher ionization potentials and higher electron affinities. The calculated electron

affinity value of TAH derivatives is greater than 3.00 eV which indicates their anionic stability towards the

oxygen and water present in air. We have also observed that donor-to-donor charge transfer states were

destabilised by deviation from equilibrium geometry, however at the same time donor-to-acceptor charge

transfer state become more favourable. The structural changes were observed to reduce the potential

impact of the donor-to-donor charge transfer states by weakening their electronic coupling to excited state.

Thus, on the basis of these computational calculation, we have conclude that the change in interfacial

geometry can enhance the importance of hot charge transfer states, which are expected to serve as more

effective gateway states for charge separation than the cold charge transfer state in triarylamine helicene.

DFT calculated reorganization energy values of studied TAH derivatives reveal that they can behave as

effective n-type materials for OLED devices. The electron injection potential barrier for TAH derivatives and

metal electrode decreases by introducing an electron withdrawing groups on TAH skeleton. In conclusion,

on the basis of these computational calculations, the TAH derivatives having an electron withdrawing group

can act as efficient optoelectronic material.

20

ICET

of ICET

of the ICET

the

energy

ICET

energy values

ICET

values

OLED

ICET

OLED devices.

ICET

devices. The

ICET

The

by

ICETby introducing

ICETintroducing an

ICETan electron

ICETelectron

computational

ICETcomputational calculations,

ICETcalculations,

optoelectronic

ICEToptoelectronic material.

ICETmaterial.

Ccalculation,

Ccalculation,

hot

Chot charge

Ccharge

effective gateway states for charge separation than the cold charge transfer state in triarylamine helicene.

Ceffective gateway states for charge separation than the cold charge transfer state in triarylamine helicene.

values Cvalues of Cof studied Cstudied

The CThe electron Celectron

electron Celectron

Sstructural

Sstructural changes

Schanges

states

Sstates by

Sby weakening

Sweakening

calculation, Scalculation, we Swe have Shave

charge Scharge transfer Stransfer states, Sstates,

effective gateway states for charge separation than the cold charge transfer state in triarylamine helicene. Seffective gateway states for charge separation than the cold charge transfer state in triarylamine helicene.

-201

7geometries

-201

7geometries

carried

-201

7carried by

-201

7by using

-201

7using

Gaussian

-201

7Gaussian 09,

-201

709, DUSHIN

-201

7DUSHIN

equilibrium

-201

7equilibrium geometry

-201

7geometry on

-201

7on

derivatives

-201

7derivatives possess

-201

7possess low-lying

-201

7low-lying

electron

-201

7electron affinities.

-201

7affinities. The

-201

7The calculated

-201

7calculated

indicates

-201

7indicates their

-201

7their anionic

-201

7anionic

that

-201

7that donor

-201

7donor-to-donor

-201

7-to-donor charge

-201

7charge

, however at the same time donor

-201

7, however at the same time donor

changes -201

7changes were -2

017

were observed -201

7observed

weakening -201

7weakening their -2

017

their

have -201

7

have conclude -201

7

conclude

Chandrashekara R Haramagatti, Priya Dhande, Ajinkya Umbarkar, Amit Joshi

Aisan Paints Ltd., Research and Technology Centre, Navi Mumbai-400703, Maharashtra. [email protected]

IT-06Influence of dispersing agents on stability of pigment dispersions

IT-07Phthalocyanine based electrochemical sensors

Dr. K R Venugopala Reddy

Department of Chemistry, Vijayanagar Srikrishnadevaraya University, Karnataka, India

There is a worldwide effort towards the development of reliable, simple and efficient electrocatalyst for

monitoring and sensing applications of bio and organic molecules. Many analytical methods, including

spectrometry, chromatography, high performance liquid chromatography, fuorescence microscopy,

chemiluminescence, and titrimetry, have been employed for the analysis of bio and organic molecules,

however, they can be inconvenient and expensive. Moreover, these methods could not satisfy the demand of

analysis in complex biological systems without interference from other molecules. Due to their innate

properties such as low cost, high sensitivity, fast response and size, electrochemical sensors are suited to

on-site analysis. The use of bare electrodes for detection of analyte molecules presents a number of

limitations, such as low sensitivity and reproducibility due to the slow electron transfer reaction between the

electrode surface and the analyte, and lower stability. As an alternative, the use of chemically modified

electrodes has been proposed, which improve the electron transfer rate, also promoting an increase in the

sensitivity of the system. In this sense, a wide variety of compounds have been used as electron transfer

mediators for electrooxidation or reduction of several target molecules. There has been an explosion of

interest in the development of electrocatalyst based on metal phthalocyanines (MPc's) due to their

fascinating optical, electronic, magnetic and electrocatalytic properties. MPc's have been explored as

electrocatalyst in variety of electrochemical techniques due to the presence of electroactive central metals

with variable oxidation states. Further the electrocatalytic performance of MPc's can be tuned by introducing

variety of functional groups (such as electron pumping or withdrawing) which leads to reactions occurring at

reduced over potentials and increased current densities rendering MPc's as good electrocatalysts.

IT-08New generation polymer membranes for water purification

and desalination applicationDr. Arun M Isloor

Dept. of Chemistry, National Institute of Technology Karnataka Surathkal, Mangalore 575 025 Ph 9448523990

E-mail : [email protected]

In the recent years, non availability of the adequate drinking water is a major concern of research across the

globe. The rapid urbanization and industrialization has resulted in the drastic pollution of fresh water sources

such as rivers, lakes, wells, borewell water etc. Due to the increased level of heavy metals/dyes/ toxic

compounds in the potable water beyond the permissible level has affected the life system. In few of the

regions, the increased concentration of various elements in water such as Arsenic, mercury, lead, cadmium

has reached to an alarming stage. Hence there is urgent need to purify these toxic elements from the potable

water source at an affordable price. Moreover, conflicts between countries/states/districts is because of the

water itself!

Among the different known techniques used for the removal of such pollutants, Membrane technology has

gained significant importance due to its low cost and effective purification. Present talk gives an overview of

different types of polymer membranes based on their applications, preparation of polymer membranes,

21

ICET

electron

ICET

electron

ICET

increased

ICET

increased current

ICET

current

New generation polymer membranes for water purification

ICET

New generation polymer membranes for water purification and desalination application

ICET

and desalination application

Dept. of Chemistry

ICET

Dept. of Chemistry

years, ICET

years, non ICET

non

urbanization IC

ET

urbanization

Celectrocatalytic

Celectrocatalytic

techniques

Ctechniques

electrocatalytic

Celectrocatalytic

electron Celectron pumping Cpumping or Cor withdrawing) Cwithdrawing)

current Ccurrent densities Cdensities

Starget

Starget

Sbased

Sbased on

Son metal

Smetal

electrocatalytic Selectrocatalytic properties. Sproperties.

techniques Stechniques due Sdue to Sto the Sthe

electrocatalytic Selectrocatalytic performance Sperformance

-201

7organic

-201

7organic

not

-201

7not satisfy

-201

7satisfy the

-201

7the

molecules.

-201

7molecules. Due

-201

7Due to

-201

7to their

-201

7their

electrochemical

-201

7electrochemical sensors

-201

7sensors are

-201

7are

molecules

-201

7molecules presents

-201

7presents

electron

-201

7electron transfer

-201

7transfer reaction

-201

7reaction

alternative,

-201

7alternative, the

-201

7the use

-201

7use of

-201

7of chemically

-201

7chemically

transfer

-201

7transfer rate,

-201

7rate, also

-201

7also promoting

-201

7promoting

compounds

-201

7compounds have

-201

7have been

-201

7been

target -201

7target molecules. -2

017

molecules. There -201

7There

metal -201

7metal phthalocyanines -2

017

phthalocyanines

properties. -201

7

properties.

characterization. It also includes preparation of few of the in-house prepared membranes and its possible

application for the water purification.

Hollow fibre membranes are considered as a New generation polymer membranes due to several

advantages over flat sheet polymer membranes. Hollow fiber membranes have become prevalent in water

treatment, desalination, cell culture, medicine, and tissue engineering. Most commercial hollow fiber

membranes are packed into cartridges which can be used for a variety of liquid and gaseous separations,

haemodialysis etc. A detailed introduction and ongoing research has been highlighted in this talk.

Dr. Jayappa Manjanna

Dept. of Chemistry, Rani Channamma University, Belagavi, Karnataka, [email protected]; Ph: 09916584954

IT-09(Nano)materials for Energy devices, Environmental

and Biomedical applications

Ceria based oxide-ion conductors for solid oxide fuel cell (SOFC) and spinel structured cathode materials for

Li-ion batteries (LIB) have been studied. The redox chemistry of technologically important metal oxides

(such as ferromagnetic metal ion doped semiconductors, new series of perovskites and multiferroic

materials) with their magnetic properties will be presented.

The recovery of valuable and/ or toxic metal ions from E-waste such as Li-ion battery (LIB) through the

chemical treatment of cathode materials collected from spent LIB will be discussed. Fe-oxide nanomaterials

have shown to absorb Mo from high level liquid waste from nuclear industries. The developments in the

engineered barrier system to isolate the nuclear waste in the repositories, especially the carbon steel/clay

mineral (montmorillonite) interaction will also be presented. Furthermore, our recent studies on the

preparation of Au, Ag and Cu nanoparticles and their alloys by green chemistry approach followed by their

antimicrobial activity as well as anticancer activity upon bio-conjugation with cancer drugs are of interest.

IT-10Synthesis and structural studies of bioactive sulfonamide derivatives

Dr. K. Jyothi

Department of Chemistry, St Joseph Engineering College, Mangaluru, India,E-mail: [email protected]

Sulfonamide derivatives are good models to study the structure-activity relationship in biologically important

small organic molecules. Sulfanilamide, being the first synthetic antibacterial agent acting on a wide range of

infections. Study of spectral and structural parameters of simple molecular models having these core

functional group helps in understanding the mechanism of action, increase the effectiveness and minimize

the side effects of such drug molecules. Structural studies reveal the capacity of molecules to form weak

interactions with the targets and hence play a key role in the drug design. These molecules have varied

activities because of their different affinity in forming hydrogen bonds and other weak interactions with

proteins and other target molecules in the body. A journey towards a better lead compound starts with

systematic molecular modifications by varying the substitutions, or substituent positions on the active

moiety, which would vary many parameters affecting the oral bioavailability and drug metabolism. In view of

the above facts, and based on our group interest, we have synthesized a series of bioactive aromatic and

heterocyclic sulphonamide derivatives. The structures of the compounds were established on the basis of

IR, NMR, Mass, UV spectra and single crystal X-ray crystallographic studies. The molecules were screened

for their anticancer activity, in vitro antitubercular and antimicrobial activity.

22

ICET

interaction

ICET

interaction will

ICET

will

nanoparticles

ICET

nanoparticles and

ICET

and

as

ICETas anticancer

ICETanticancer

ICETactivity

ICETactivity

Synthesis and structural studies of bioactive sulfonamide derivatives

ICET

Synthesis and structural studies of bioactive sulfonamide derivatives

D

ICET

Department of Chemistry

ICET

epartment of Chemistry

Sulfonamide ICET

Sulfonamide derivatives ICET

derivatives are ICET

are ICET

organic ICET

organic molecules. ICET

molecules.

Study ICET

Study of ICET

of

Ccollected

Ccollected

liquid

Cliquid waste

Cwaste

the

Cthe nuclear

Cnuclear waste

Cwaste

will Cwill also Calso be Cbe presented. Cpresented.

and Cand their Ctheir

upon Cupon

Spresented.

Spresented.

ions

Sions from

Sfrom E

SE-waste

S-waste

collected Scollected from Sfrom spent Sspent LIB SLIB

waste Swaste from Sfrom nuclear Snuclear Sin Sin the Sthe

-201

7, Belagavi, Karnataka, India

-201

7, Belagavi, Karnataka, [email protected]; Ph: 09916584954

-201

[email protected]; Ph: 09916584954

(Nano)materials for Energy devices, Environmental

-201

7(Nano)materials for Energy devices, Environmental

and

-201

7and spinel

-201

7spinel structured

-201

7structured cathode

-201

7cathode

chemistry

-201

7chemistry of

-201

7of technologically

-201

7technologically

semiconductors,

-201

7semiconductors, new

-201

7new series

-201

7series of

-201

7of perovskites

-201

7perovskites

-waste -201

7-waste such -2

017

such

will -201

7

will

Dr. Vijayendra S. Shetti

Department of Chemistry, BMS College of Engineering, Bangalore

This talk will focus on the synthesis of functionalized heteroporphyrins (core-modified porphyrins), their

contracted and expanded analogues. Also, the first examples of novel polymer called Poly[2, 6-

aminoazulene] will be discussed

IT-11Heteroporphyrinoids, their conjugates and Polyazulene

Establishing sructure property relationship in drug partitioning into and release from niosomes: physical chemistry insights

with anti-inflammatory drugs

IT-12

Moumita Dasgupta, Nand Kishore*

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.E-mail addresses: [email protected], [email protected]

Understanding physical chemistry underlying interactions of drugs with delivery formulations is extremely

important in devising effective drug delivery systems. The partitioning and release kinetics of diclofenac and

naproxen from Brij 30 and Triton X-100 niosomal formulations have been addressed based on structural

characterization, partitioning energetics and release kinetics, thus establishing relationship between

structures and observed properties. Niosomes are vesicular systems with an aqueous interior core

consisting of non-ionic surfactants, which constitute the bilayer of these vesicles.1-3 Both the drugs

partitioned in nonpolar regions of TX-100 niosomes via stacking of aromatic rings. The combined effects of

interactions of the drugs with polar head groups and the rigidity of the niosome vesicles determine entry and

partitioning of drugs into niosomes. The observed slower rate of release of the drugs from the drug

encapsulated niosomes of TX-100 than those of Brij 30, suggest stable complexation of drugs in the

nonpolar interior of the former. No release of drugs from the niosomes was observed till 24 h even upon

varying pH conditions without SDS. However SDS in drug loaded niosomes led to release of drugs in as

early as 6 h. The sustained pattern of in vitro release kinetics of the drugs thus observed from our niosomal

preparations suggest these vesicular systems to be promising for pharamaceutical applications as potential

drug delivery vehicles.

Keywords: Niosomes; Drug partitioning; calorimetry

References:

(1) Liu, T.; Guo, R. Preparation of a Highly Stable Niosome and Its Hydrotrope-Solubilization Action to

Drugs. Langmuir 2005, 21, 11034-11039.

(2) Kato, K.; Walde, P.; Koine, N.; Ichikawa, S.; Ishikawa, T.; Nagahama, R.; Ishihara, T.; Tsujii, T.; Shudou, M.;

Omokawa, Y.; et al. Temperature-Sensitive Nonionic Vesicles Prepared from Span 80 (Sorbitan

Monooleate). Langmuir 2008, 24, 10762-10770.

(3) Sennato, S.; Bordi, F.; Cametti, C.; Marianecci, C.; Carafa, M.; Cametti,

M. Hybrid Niosome Complexation in the Presence of Oppositely Charged Polyions. J. Phys. Chem. B

2008, 112, 3720-3727.

23

ICET

-100

ICET

-100

polar

ICET

polar head

ICET

head groups

ICET

groups

niosomes.

ICETniosomes. The

ICETThe observed

ICETobserved

of

ICETof TX

ICETTX-100

ICET-100 TX-100 TX

ICETTX-100 TX than

ICETthan those

ICETthose

former

ICETformer.

ICET. No

ICETNo release

ICETrelease of

ICETof

conditions

ICET

conditions without

ICET

without SDS.

ICET

SDS. However

ICET

However

sustained

ICET

sustained pattern

ICET

pattern of

ICET

of

preparations

ICET

preparations suggest

ICET

suggest these

ICET

these vesicular

ICET

vesicular

delivery

ICET

delivery vehicles.

ICET

vehicles.

eywords: ICET

eywords: Niosomes; ICET

Niosomes; Drug ICET

Drug

CNiosomes

CNiosomes

which

Cwhich constitute

Cconstitute

-100 C-100 niosomes Cniosomes via Cvia stacking Cstacking

groups Cgroups and Cand the Cthe

observed Cobserved

SThe

SThe

formulations

Sformulations

release

Srelease kinetics,

Skinetics,

are Sare vesicular Svesicular systems Ssystems

constitute Sconstitute the Sthe bilayer Sbilayer

stacking Sstacking

-201

7Establishing sructure property relationship in drug partitioning into

-201

7Establishing sructure property relationship in drug partitioning into

and release from niosomes: physical chemistry insights

-201

7and release from niosomes: physical chemistry insights

Moumita Dasgupta, Nand Kishore*

-201

7Moumita Dasgupta, Nand Kishore*

echnology Bombay

-201

7echnology Bombay, P

-201

7, Powai, Mumbai 400 076, India.

-201

7owai, Mumbai 400 076, India.

-mail addresses: [email protected], [email protected]

-201

7-mail addresses: [email protected], [email protected]


-201

7Understanding physical chemistry underlying interactions of drugs with delivery formulations is extremely

partitioning -201

7partitioning and -2

017

and release -201

7release

formulations -201

7formulations have -2

017

have been -201

7been

kinetics, -201

7

kinetics, thus -201

7

thus

OP-01Molecular design and synthesis of metal free diphenylamine

based sensitizer for dye sensitized solar cellsRajalakshmi K and Airody Vasudeva Adhikari

Department of Chemistry, National Institute of Technology, Surathkal, Mangaluru,Karnataka- 575 025 INDIA.

E-mail: [email protected] and [email protected]

Human society relies on fossil fuel for the energy needs and its excessive consumption has led to its

depletion. The combustion of fossil fuel has resulted in the environment hazards also. Globally the concern

of such problems has spurred the technological endeavor of renewable energy. When it comes to renewable

energy, solar energy is the most advantageous choice. Dye sensitized solar cell (DSSC) is one among

different types of solar cells which is a cost effective technology that features relatively high efficiency, long

term stability and easy fabrication. Dyes or sensitizers serve as a solar energy absorber in DSSC, whose

properties affect the light harvesting efficiency and the overall photoelectric conversion efficiency. Metal-free

sensitizer is a type of sensitizer possessing properties like high molecular extinction coefficient, relatively

environmental friendly, facile to synthesis and tunable electrochemical-absorption properties. As sensitizer

is one of the key components in DSSC, it is receiving extreme research attention. Literatures show that dyes

based on phenothiazine, carbazole, coumarin, fluorine, triphenylamine, diphenylamine and indoline

showed respectable conversion efficiency, mainly due to its good electron donor capacity. A new Donor-π-

Acceptor dye was designed and synthesized with diphenylamine as an electron donor moiety. The density

functional study was carried out to study the Frontier Molecular Orbital energy states. The synthesized dye

was characterized using various spectral and elemental analyses. Further, the optical and electrochemical

property was investigated using spectrophotometry and cyclic voltammetry respectively.

Keywords: Dye sensitized solar cells; sensitizer; diphenylamine.

A new rapid, convenient and eco-friendly method for the synthesis of 5-amino-1,3,4-thiadiazole-2-thiol based heterocyclic azo dyes

by using different catalysts – A Green Protocol

Harisha. S, Jathi Keshavayya*, Prasanna S.M and Ravi B. N

Department of PG Studies and Research in Chemistry, School of Chemical Sciences,Kuvempu University, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India

A novel solvent-free, efficient and green approach has developed for the synthesis of three heterocyclic azo

dyes by the diazo coupling of 5-amino-1,3,4-thiadiazole-2-thiol with barbituric acid derivatives. The process

was carried out in the presence of Potassium Hydrogen Sulphate (Inorganic catalyst), Sulfanilic acid

(Organic catalyst) and Montmorillonite (A Nano catalyst) by a grinding method at room temperature. This

Green Methodology has to overcome the limitations and drawbacks of the previously reported methods like,

low temperature, use of acids, alkalies and toxic solvents, modest yield, long reaction time, pH maintenance

and also instability of diazonium salts at room temperature. Hence, we have developed an operationally

simple, inexpensive method for effective diazotization and coupling process from radially available reagents

and operators in the laboratory. Also, we reported the procedure, duration and yields of the prepared azo

dyes by using different catalyst at room temperature. Therefore, attractive advantages of the process include

OP-02

24

ICET

study

ICET

study the

ICET

the

spectral

ICETspectral and

ICET

and

using

ICETusing spectrophotometry

ICETspectrophotometry

sensitized

ICETsensitized solar

ICETsolar cells;

ICETcells; sensitizer;

ICETsensitizer;

A new rapid, convenient and eco-friendly method for the synthesis of

ICET

A new rapid, convenient and eco-friendly method for the synthesis of 5-amino-1,3,4-thiadiazole-2-thiol based heterocyclic azo dyes

ICET

5-amino-1,3,4-thiadiazole-2-thiol based heterocyclic azo dyes by using different catalysts – A Green Protocol

ICET

by using different catalysts – A Green Protocol

Harisha. S, Jathi K ICET

Harisha. S, Jathi K

Department of PG Studies and Research in Chemistry ICET

Department of PG Studies and Research in Chemistryuvempu University IC

ET

uvempu University

Cmainly

Cmainly due

Cdue

synthesized

Csynthesized with

Cwith diphenylamine

Cdiphenylamine

the Cthe F CFrontier Crontier Molecular CMolecular

and Cand elemental Celemental

spectrophotometry Cspectrophotometry

Selectrochemical-absorption

Selectrochemical-absorption

receiving

Sreceiving extreme

Sextreme

coumarin,

Scoumarin, fluorine,

Sfluorine, triphenylamine,

Striphenylamine,

due Sdue to Sto its Sits good Sgood

diphenylamine Sdiphenylamine

-201

7consumption

-201

7consumption

also.

-201

7also. Globally

-201

7Globally

When

-201

7When it

-201

7it comes

-201

7comes to

-201

7to renewable

-201

7renewable

solar

-201

7solar cell

-201

7cell (DS

-201

7(DSSC)

-201

7SC) is

-201

7is one

-201

7one

features

-201

7features relatively

-201

7relatively high

-201

7high efficiency

-201

7efficiency

solar

-201

7solar energy

-201

7energy absorber

-201

7absorber

photoelectric

-201

7photoelectric conversion

-201

7conversion

high

-201

7high molecular

-201

7molecular extinction

-201

7extinction

electrochemical-absorption -201

7electrochemical-absorption

extreme -201

7extreme research -2

017

research attention. -201

7attention.

triphenylamine, -201

7

triphenylamine,

simple conversion of reactants into products, inexpensive procedure, good yield and recyclability of the

Nano catalyst. Finally, the structural conformations of all the synthesized compounds have been

accomplished by UV-Visible, FT-IR, 1HNMR, and mass spectrometric techniques. Prepared azo dyes has

been used as modifiers in sensor applications for sensitive determination of pharmaceutical drug

compounds, neurotransmitters, amino acids etc. Selectivity, sensitivity, stability and reproducibility of the

modified electrode have been analyzed. Electrode characterization has been carried out using

electrochemical impedance spectroscopy (EIS), CV, SEM and XRD. Further, biological studies have also

been carried out using real samples.

Keywords: Azo Dyes; Diazotization; Montmorillonite; Green protocol; Electrochemical Investigations

OP-03Determination of the dyeing method of flame retardant aramid

technical textiles using DSC Microscope

M S Yogendra Kumar*, F V Varghese, R G Revaiah, T M Kotresh and U K Singh

Defence Bioengineering and Electromedical Laboratory, C V Raman Nagar, Bengaluru - 560093 India

*E-mail: [email protected] & [email protected]

Abstract: Military personnel, aviators, fire fighters and other first responders arriving at an emergency scene

have traditionally been provided with flame retardant protective clothing. The chemical compositions and

dyeing method of these clothing materials are often critical owing to the extreme temperature and other

conditions they are exposed to. Therefore, these materials have to be properly analyzed for the above

properties as part of the quality assurance of the products before it is supplied to the Armed Forces.

Dope dyeing is followed over traditional dyeing methods for improving the color-fastness with lesser color

deviation. Here the pigments are added to the liquid polymer solution before the synthetic fibers are

extruded. Thus the pigments become part of the fiber. One of the challenges in dope dyeing is the relatively

high cost. Therefore, there is chance of one adopting traditional dyeing methods for commercial benefit.

In the present study, a novel method for the determination of the method of dyeing the flame retardant

aramid technical textiles using Differential Scanning Calorimeter (DSC) Microscope is developed. Dope

dyed and traditionally dyed Nomex IIIA (NIIIA) fabrics were simultaneously exposed to temperature range of

25-350ºC. Traditionally dyed NIIIA fabric loses its color above 250ºC; while the dope dyed fabric does not

lose the color. The stripping-out of the color from the fabric could not have occurred had the coloring

pigment been trapped inside the cross-section of the fibre as in the case of dope-dyed fabric. The weight

loss found with the traditionally dyed fabric between 200-350˚C in the Thermogravimetric analysis (TGA)

correlates to the color loss observed in the DSC experiment. Thus the color loss in the case of the

traditionally dyed fabric is due to loss of “Coloring agent” or the dye which does not happen in the case of the

dope dyed fabric.

Keywords: Nomex IIIA, Flame Retardant, Dope dyeing, TGA, DSC Microscope

25

ICET

assurance

ICET

assurance

traditional

ICET

traditional dyeing

ICET

dyeing

pigments

ICETpigments are

ICETare added

ICETadded to

ICETto the

ICETthe

pigments

ICETpigments become

ICETbecome part

ICETpart of

ICETof the

ICETthe

there

ICETthere is

ICETis chance

ICETchance of

ICETof one

ICETone adopting

ICETadopting

study

ICET

study,

ICET

, a

ICET

a novel

ICET

novel method

ICET

method for

ICET

for

technical

ICET

technical textiles

ICET

textiles using

ICET

using Differential

ICET

Differential

traditionally

ICET

traditionally dyed

ICET

dyed Nomex

ICET

Nomex

25-350ºC. ICET

25-350ºC. ICET

T ICET

Traditionally ICET

raditionally dyed ICET

dyed

color ICET

color. ICET

. The ICET

The stripping-out ICET

stripping-out

pigment been trapped inside the cross-section of the fibre as in the case of dope-dyed fabric. The weight ICET

pigment been trapped inside the cross-section of the fibre as in the case of dope-dyed fabric. The weight

the IC

ET

the

Care

Care often

Coften

Therefore,

CTherefore, these

Cthese materials

Cmaterials

assurance Cassurance of Cof the Cthe products Cproducts

dyeing Cdyeing methods Cmethods

the Cthe liquid Cliquid

Sand

Sand other

Sother first

Sfirst

retardant

Sretardant protective

Sprotective

often Soften critical Scritical owing Sowing

materials Smaterials have Shave

before Sbefore

-201

7Investigations

-201

7Investigations

Determination of the dyeing method of flame retardant aramid

-201

7Determination of the dyeing method of flame retardant aramid technical textiles using DSC Microscope

-201

7technical textiles using DSC Microscope

arghese, R G Revaiah, T M K

-201

7arghese, R G Revaiah, T M Kotresh and U K Singh

-201

7otresh and U K Singh

Defence Bioengineering and Electromedical Laboratory

-201

7Defence Bioengineering and Electromedical Laboratory,

-201

7,

, Bengaluru - 560093 India

-201

7, Bengaluru - 560093 India

-mail: [email protected] & [email protected]

-201

7-mail: [email protected] & [email protected]

first -201

7first responders -2

017

responders

protective -201

7

protective clothing. -201

7

clothing.

OP-04Development and validation of RP-HPLC method for the analysis

of Rimantadine Hydrochloride in pure form1 2J.Mamatha and Dr. N. Devanna

1Department of Chemistry, G. Pullaiah College of Engineering & Technology, Kurnool, Andhra Pradesh Mail-id: [email protected]

2Department of Chemistry, JNTU College of Engineering., Anantapuramu, Andhra Pradesh Mail-id: [email protected]

The number of drugs introduced in the market is increasing every year. Very often there is a time lag from the

date of introduction of a drug into the market to the date of its inclusion in pharmacopoeias. This happens

because of the possible uncertainties in the continuous and wider usage of these drugs, reports of new

toxicities, development of patient resistance and introduction of better drugs by competitors. Under these

conditions standard analytical procedures for these drugs may not be available in the pharmacopoeias.

Thus there is a scope to develop newer analytical methods for the novel drugs introduced in the market and

to validate these methods as per the standard regulations and guidelines. The study focuses on the

analytical method development and validation of Rimantadine hydrochloride (RMT) in its pure form using

reverse phase high performance liquid chromatographic UV absorption technique. A precolumn

derivatization of RMT was conducted with Anthraquinone-2-Sulphonyl chloride(ASC) to result in RMT-ASC

derivative. RMT-ASC derivative was analyzed on C-18 column using Acetonitrile and 0.005 mM 1-

octanesulfonic acid sodium salt (OSC) solution in 60:40 ratio as a mobile phase maintaining a flow rate of 1

ml per minute at ambient temperature under isocratic condition using UV-Vis detector at 260 nm wavelength.

Keywords: Rimantadine Hydrochloride (RMT); Anthraquinone-2-sulphonyl chloride (ASC); 1-Octane

sulphonic acid sodium salt (OSC); Derivatization.

OP-05Evaluation of anti-inflammatory activity of some novel


*Channamma M 1, Raga Basawaraj2 and N.V.Kalyani*&2 BLDEA's SSM College of Pharmacy and Research Centre-Vijaypur

1 Karnataka College of Pharmacy-BidarE-mail ID : [email protected]

In the present work a investigation is taken on anti-inflammatory active Benzofuran moiety coupled with

Pyrimidine. The benzofuranpyrimidine derivatives were evaluated for anti-inflammatory activity using

Carrageean induced rat paw oedema method. Animals in Group 1 served as control (0.2 ml of 2% gum

acacia), Group 2 served as standard treated (Diclofenac sodium 4.5 mg/kg b.w p.o), Groups 3,4,5,6 and 7

served as benzofuranpyrimidine derivatives treated groups(50 mg/kg b.w, p.o.). The reported values clearly

shown that the compound (5c) and (5d) exhibited good activity. Other representative compounds of the

series possess moderate activity when compared to standard drug Diclofenac sodium. The Pyrimidine

analogous of Benzofuran derivatives screened for anti-inflammatory activity, amongst some compounds of

the series showed good activity, when compared to reference standard drug. Hence a detailed study on this

moiety may be further carried out, which require detailed toxicity study. Therefore the proper molecular

modification may enhance the activity of the compounds.

Keywords: Benzofuran; Pyrimidine; Anti-inflammatory

26

ICET

Derivatization.

ICET

Derivatization.

Evaluation of anti-inflammatory activity of some novel

ICETEvaluation of anti-inflammatory activity of some novel


ICETbenzofuranpyrimidine derivatives

*Channamma M 1, Raga Basawaraj2 and N.V

ICET

*Channamma M 1, Raga Basawaraj2 and N.V*&2

ICET

*&2 BLDEA's S

ICET

BLDEA's SSM College of Pharmacy and Research Centre-

ICET

SM College of Pharmacy and Research Centre-

present ICET

present work ICET

work a ICET

a investigation ICET

investigation

The ICET

The benzofuranpyrimidine ICET

benzofuranpyrimidine

induced ICET

induced

Cisocratic

Cisocratic

Hydrochloride

CHydrochloride (RMT);

C(RMT); Anthraquinone-2-sulphonyl

CAnthraquinone-2-sulphonyl

Derivatization.CDerivatization. SC

SC-18

S-18

60:40

S60:40 ratio

Sratio as

Sas

isocratic Sisocratic condition Scondition using Susing

Anthraquinone-2-sulphonyl SAnthraquinone-2-sulphonyl

-201

7pharmacopoeias.

-201

7pharmacopoeias.

these

-201

7these drugs,

-201

7drugs, reports

-201

7reports

toxicities, development of patient resistance and introduction of better drugs by competitors. Under these

-201

7toxicities, development of patient resistance and introduction of better drugs by competitors. Under these

available

-201

7available in

-201

7in the

-201

7the pharmacopoeias.

-201

7pharmacopoeias.

drugs

-201

7drugs introduced

-201

7introduced in

-201

7in

guidelines.

-201

7guidelines. The

-201

7The study

-201

7study

hydrochloride

-201

7hydrochloride (RMT)

-201

7(RMT)

c

-201

7c U

-201

7UV

-201

7V a

-201

7ab

-201

7bs

-201

7so

-201

7or

-201

7rp

-201

7pt

-201

7ti

-201

7io

-201

7on

-201

7n t

-201

7t

Anthraquinone-2-Sulphonyl

-201

7Anthraquinone-2-Sulphonyl chloride(ASC)

-201

7chloride(ASC)

column -201

7column using -2

017

using

a -201

7

a mobile -201

7

mobile

using -2

017

using

OP-06Synthesis, characterization and effect of catalytic activity on

supported Co-Ce catalyst for CO oxidation

Gaurav Rattan

Dr. S.S.B. University Institute of Chemical Engineering and Technology, Panjab University, Chandigarh-160014, [email protected]

Carbon monoxide is the main pollutant produced during the burning of fossil fuel. During the cold start

period of the vehicle most of the CO, hydrocarbons and other particulate matter are released in the

environment because of incomplete combustion of fuel. A number of catalysts based on noble metals have

been developed. But because of their expensiveness and rarity of noble metals, base metals like Ni, Cu, Mn,

Co, Fe, Cr, etc. have been considered as an alternative to prepare the catalysts for CO oxidation [3].In the

present paper cobalt ceria catalyst supported on alumina was prepared by wet impregnation, co-

precipitation and sol-gel method where cobalt composition was varied from 43 – 60% and the catalyst

having good results have been calcined at different temperatures. The catalytic performance was tested for

CO oxidation. Also the best catalyst have been characterized by XRD, SEM & TGA analysis. Further it was

observed that the catalyst containing 50wt% cobalt prepared by sol-gel method showed 100% conversion at

temperature of 1150C. Also the 50 wt% cobalt catalyst was calcined at different temperatures varying from

450 – 700 0C. The catalyst calcined at 500°C has better dispersion of particles and better catalytic activity

than the catalyst calcined at other temperatures.

Keywords: Carbon monoxide; Oxidation; Calcination effect.

OP-07A thiophene derivative for application in optoelectronic devices

1 *Viprabha K , and Udayakumar Dalimba

Synthetic Organic Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Srinivasnagar-575 025, India

1E-mail: [email protected] *[email protected], [email protected]

Organic semiconducting materials have received appreciable attentions because of their favorable

applications in the areas viz., flexible electronic devices such as radio frequency identification (RFID) tags,

smart cards, electronic papers as well as organic field effect transistors (OFETs), organic light emitting

diodes (OLEDs), organic solar cells (OSCs) and sensors. To date a number of small molecules/polymers

have been synthesized. One of the main criteria to achieve appreciable low bad gap (Eg) in the range of

semiconductor is the use of strong donor and acceptor moieties at alternating sequence. Considering this, a

linear conjugated molecule possessing thiophene as donor and 1,3,4-oxadiazole as an acceptor unit has

been synthesized. Structural confirmation has been done using 1H NMR spectroscopy. UV-Vis absorption

and fluorescence emission spectroscopic tools are utilized to study the optical properties. The study

showed that the molecule absorbs at �max of 384nm and emits the photons in bluish-green region. Cyclic

voltammetry studies evaluated the bandgap and molecular energy levels of the molecules. The study

exhibited the narrow band gap (1.8 eV) due to low lying LUMO and high lying HOMO energy levels as a result

of extended pi-conjugation and alternating donor- acceptor sequence of the molecule. The results suggest

that the molecule could be promising candidate for optoelectronics.

Keywords: Conjugated molecule, thiophene, optical properties, fluorescence emission, cyclic

voltammetry.

27

ICET

A thiophene derivative for application in optoelectronic devices

ICET

A thiophene derivative for application in optoelectronic devices1

ICET1V

ICETViprabha K

ICETiprabha K , and Udayakumar Dalimba

ICET, and Udayakumar Dalimba

Synthetic Organic Chemistry Laboratory

ICETSynthetic Organic Chemistry Laboratory

National Institute of T

ICET

National Institute of Technology Karnataka, Srinivasnagar

ICET

echnology Karnataka, SrinivasnagarNational Institute of Technology Karnataka, SrinivasnagarNational Institute of T

ICET

National Institute of Technology Karnataka, SrinivasnagarNational Institute of TE-mail: [email protected] *[email protected], [email protected]

ICET

E-mail: [email protected] *[email protected], [email protected]

semiconducting

ICET

semiconducting materials

ICET

materials

applications

ICET

applications in

ICET

in the

ICET

the areas

ICET

areas viz.,

ICET

viz., flexible

ICET

flexible

cards, ICET

cards, electronic ICET

electronic papers ICET

papers ICET

(OLEDs), ICET

(OLEDs), organic ICET

organic

synthesized. ICET

synthesized.

is IC

ET

is the IC

ET

the

C450 – 700 0C. The catalyst calcined at 500°C has better dispersion of particles and better catalytic activity

C450 – 700 0C. The catalyst calcined at 500°C has better dispersion of particles and better catalytic activity

temperatures.

Ctemperatures.

Oxidation;

COxidation; Calcination

CCalcination effect.

Ceffect.

A thiophene derivative for application in optoelectronic devicesCA thiophene derivative for application in optoelectronic devices, and Udayakumar DalimbaC

, and Udayakumar Dalimba

Sprepared

Sprepared

catalyst

Scatalyst was

Swas calcined

Scalcined

450 – 700 0C. The catalyst calcined at 500°C has better dispersion of particles and better catalytic activity S450 – 700 0C. The catalyst calcined at 500°C has better dispersion of particles and better catalytic activity

effect.Seffect.

-201

7During

-201

7During

matter

-201

7matter are

-201

7are released

-201

7released

based

-201

7based on

-201

7on noble

-201

7noble metals

-201

7metals

metals,

-201

7metals, base

-201

7base metals

-201

7metals like

-201

7like Ni,

-201

7Ni,

catalysts

-201

7catalysts for

-201

7for CO

-201

7CO oxidation

-201

7oxidation

prepared

-201

7prepared by

-201

7by wet

-201

7wet impregnation,

-201

7impregnation,

varied

-201

7varied from

-201

7from 43

-201

743 –

-201

7– 60%

-201

760%

temperatures.

-201

7temperatures. The

-201

7The catalytic

-201

7catalytic performance

-201

7performance

characterized

-201

7characterized by

-201

7by XRD

-201

7XRD,

-201

7, SEM

-201

7SEM &

-201

7& TGA

-201

7TGA

prepared -201

7prepared by -2

017

by sol-gel -201

7sol-gel method -2

017

method

calcined -201

7calcined at -2

017

at different -201

7different

450 – 700 0C. The catalyst calcined at 500°C has better dispersion of particles and better catalytic activity -201

7

450 – 700 0C. The catalyst calcined at 500°C has better dispersion of particles and better catalytic activity

mailto:[email protected]

OP-08

Design and synthesis of novel aryl substituted thiazolidinone derivatives by suzuki coupling for anticancer activity

1 1*Majalkere Krishnakishore , Balladka Kunhanna Sarojini , 2 3

Shama Rao and Prashanth Naik1Department of Industrial Chemistry, Mangalore University,

Mangalagangothri – 574 199, India2Nitte Unviersity center for stem cell research and regenerative medicine,

Deralakatte, Mangaluru, Karnataka 575018, India3Department of Biosciences, Mangalore University, Mangalagangothri - 574 199, India.

E-mail: [email protected], *[email protected]

In the present study, we have focused on the design and synthesis of thiazolidinone scaffold for cytotoxic

activity. Initially 4-{[(4-sulfamoylphenyl)carbamothioyl]amino}benzenesulfonamide is synthesized, which

is then converted into 4-{(2Z)-4-chloro-5-oxo-2-[(4-sulfamoylphenyl)imino]-1,3-thiazolidin-3-

yl}benzenesulfonamide, which are derivatized by treating them with different aryl substituted boronic acids

by Suzuki coupling. All the compounds are characterized by FTIR, 1H-NMR, 13C-NMR, LC-MS

spectroscopy. Cytotoxic activity study is carried out for these compounds using HEPG 2 cell line. Some of

the newly synthesized compounds have shown promising antiproliferative activity.

OP-09Spectral and morphological studies on bischalcone doped polylactic

acid (PLA) thin films for optoelectronics applicationsa,b *bAmmembal Jaya Pai , Balladka Kunhanna Sarojini ,

b cKishori Ramachandra Harshitha , and Bantwal Shivarama Holla

a Department of Chemistry, Vivekananda College of Engineering and Technology, Nehru Nagar -574203, Puttur, Karnataka, India.

b Department of Industrial Chemistry, Mangalore University,Mangalagangothri-574199,Mangaluru,Karnataka,India.

c Department of Postgraduate Studies in Chemistry, Shri Dharmasthala Manjunatheshwara College, *Ujire-574240, Belthangadi, Karnataka, India. E-mail:[email protected]

Biopolymer-Polylactic acid doped with bischalcone, 1, 3-di (4-chlorobenzylidene) cyclohexan-2-one is

found to show wonderful optical properties for optoelectronics applications. This paper focuses on the

preparation of polylactic acid thin films with different concentrations 2%, 4%, 6%, 8% (w/v) of the dopant by

solvent casting method and their characterization by spectral and morphological studies- UV, IR, PL, SEM

and XRD. The absorbance of UV at �max 300nm is observed for PLA and for the doped PLA, �max is

observed at �max 340nm. It is observed that as the dopant concentration increases, the intensity of

absorbance also increases indicating the UV blocking property of the film with doped bischalcone. Thus, the

composite material obtained by doping the bischalcone into the polymer matrix, PLA is found to block UV

radiations, which could make it a versatile material for optical applications.

Keywords: Biopolymer, PLA, thin films, bischalcones, Dopant

28

ICET

Spectral and morphological studies on bischalcone doped polylactic

ICET

Spectral and morphological studies on bischalcone doped polylactic

acid (PLA) thin films for optoelectronics applications

ICET

acid (PLA) thin films for optoelectronics applicationsa,b

ICETa,bAmmembal Jaya P

ICETAmmembal Jaya Pai

ICETai , Balladka K

ICET, Balladka K

Kishori Ramachandra Harshitha

ICETKishori Ramachandra Harshitha


ICETDepartment of Chemistry, Vivekananda College of Engineering and T

ICET, Vivekananda College of Engineering and T

Nehru Nagar -574203, P

ICET

Nehru Nagar -574203, Pb

ICET

b Department of Industrial Chemistry

ICET

Department of Industrial ChemistryMangalagangothri-574199,Mangaluru,Karnataka,India.

ICET

Mangalagangothri-574199,Mangaluru,Karnataka,India.Department of P

ICET

Department of Postgraduate Studies in Chemistry

ICET

ostgraduate Studies in ChemistryUjire-574240, Belthangadi, Karnataka, India.

ICET

Ujire-574240, Belthangadi, Karnataka, India.

-P ICET

-P ICET

olylactic ICET

olylactic acid ICET

acid ICET

wonderful ICET

wonderful

CSpectral and morphological studies on bischalcone doped polylactic CSpectral and morphological studies on bischalcone doped polylactic

acid (PLA) thin films for optoelectronics applicationsCacid (PLA) thin films for optoelectronics applicationsa,bCa,b, Balladka KC, Balladka K

Sthese

Sthese

promising

Spromising antiproliferative

Santiproliferative

Spectral and morphological studies on bischalcone doped polylactic SSpectral and morphological studies on bischalcone doped polylactic

-201

7Nitte Unviersity center for stem cell research and regenerative medicine,

-201

7Nitte Unviersity center for stem cell research and regenerative medicine,

, Mangalagangothri - 574 199, India.

-201

7, Mangalagangothri - 574 199, India.E-mail: [email protected], *[email protected]

-201

7E-mail: [email protected], *[email protected]

, we have focused on the design and synthesis of thiazolidinone scaffold for cytotoxic

-201

7, we have focused on the design and synthesis of thiazolidinone scaffold for cytotoxic

4-{[(4-sulfamoylphenyl)carbamothioyl]amino}benzenesulfonamide

-201

74-{[(4-sulfamoylphenyl)carbamothioyl]amino}benzenesulfonamide is

-201

7is synthesized,

-201

7synthesized,

m

-201

7mo

-201

7oy

-201

7yl

-201

7lp

-201

7ph

-201

7he

-201

7en

-201

7ny

-201

7yl

-201

7l)

-201

7)i

-201

7im

-201

7mi

-201

7in

-201

7no

-201

7o]

-201

7]

them

-201

7them with

-201

7with different

-201

7different aryl

-201

7aryl substituted

-201

7substituted

r

-201

7ri

-201

7iz

-201

7ze

-201

7ed

-201

7d b

-201

7by

-201

7y F

-201

7FT

-201

7TI

-201

7IR

-201

7R,

-201

7, 1

-201

71H

-201

7H

these -201

7these compounds -2

017

compounds using -201

7using

antiproliferative -201

7antiproliferative

















OP-10Establishing Sructure Property Relationship In Drug Partitioning Into

And Release From Niosomes: Physical Chemistry Insights With Anti-inflammatory Drugs

aMoumita Dasgupt , Nand Kishore*

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.

E-mail: [email protected], [email protected]

















29

ICET

in

ICET

in

vesicular

ICET

vesicular systems

ICET

systems

Drug

ICETDrug partitioning;

ICETpartitioning; calorimetry

ICETcalorimetry

Cdrugs

Cdrugs

However

CHowever SDS

CSDS in

Cin

Cvitro

Cvitro release

Crelease kinetics

Ckinetics

systems Csystems to Cto be Cbe promising Cpromising

Sslower

Sslower

of

Sof Brij

SBrij 30,

S30, suggest

Ssuggest

drugs Sdrugs from Sfrom the Sthe niosomes Sniosomes

in Sin drug Sdrug loaded Sloaded

kinetics Skinetics

-201


-201


release

-201

7release kinetics

-201

7kinetics of

-201

7of diclofenac

-201

7diclofenac

addressed

-201

7addressed based

-201

7based on

-201

7on

establishing

-201

7establishing relationship

-201

7relationship

systems

-201

7systems with

-201

7with an

-201

7an aqueous

-201

7aqueous

bilayer

-201

7bilayer of

-201

7of these

-201

7these vesicles.1-3

-201

7vesicles.1-3

stacking

-201

7stacking of

-201

7of aromatic

-201

7aromatic rings.

-201

7rings.

rigidity

-201

7rigidity of

-201

7of the

-201

7the niosome

-201

7niosome

slower -201

7slower rate -2

017

rate of -201

7of release -2

017

release

suggest -201

7

suggest stable -201

7

stable

niosomes -2

017

niosomes

OP-11Crystal structure analysis and bioactivity of

N-(5-methylsalicylidene)aniline1 2*

S.Shalini and C. R. Girija1Department of Chemistry, SSMRV Degree College, 4th T Block, Jayanagar, Bangalore -560 041, India.

2Department of PG studies in Chemistry, Govt.Science College, Nrupatunga Road, Bangalore-560001,India

2*E-mail: [email protected]

Schiff bases are the compounds carrying imine or azomethine (–C=N–) functional group.These are the

condensation products of primary amines with carbonyl compounds and were first reported by Hugo Schiff.

N-substituted imines, known as Schiff bases represent one of the most widely used families of organic

compounds that have gained importance in medicinal and pharmaceutical fields due to a broad spectrum of

biological activities like anti-inflammatory, analgesic, antimicrobial, anticonvulsant, antitubercular,

antioxidant, anthelmintic and radiopharmaceuticals for cancer targeting. The nitrogen atom of azomethine

may be involved in the formation of a hydrogen bond with the active centers of cell constituents and

interferes in normal cell processes. They have also been used as model systems for biological macro-

molecules. In view of these importance, the crystal structure is determined using X-ray diffraction technique

and the results are extrapolated for QSAR studies to know the biological activity of the title compound using

online molinspirations program. Single crystals of the title compound (C14H13NO) were grown by slow

evaporation method using ethanol as solvent at room temperature. The compound is known to crystallise in

the monoclinic system and space group P21/n with unit cell parameters a= 4.707(3)Å, b= 19.257(13) Å, c

= 12.300(8) Å, �=90.00, = 95.70(3) ,� = 90.00 ,V= 1109.4(13) Å3, Z = 4, Dx = 1.265 Mg m-3 and �

=0.080 mm-1 . The structure was solved and refined with the olex2 program. The final R value is found to be

0.1582. Calculation of molecular properties (Log P, TPSA, number of hydrogen bond donors and acceptors,

molecular weight, number of rotatable bonds etc.) and prediction of bioactivity score for drug targets (GPCR

ligands, kinase inhibitors, ion channel modulators, enzymes and nuclear receptors) have been performed

using online molinspirations program.The obtained values are in accordance with the Lipinski's rule of five,

indicating moderate biological activity of the title compound.Hence the compound serves as a potential

pharmacophore, in particular as an antibacterial agent.

Keywords: N-(salicylidene)aniline ; X-ray crystallography; bioactivity score ; pharmacophore

30

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,� = 90.00

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,� = 90.00

solved

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and

molecular

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of

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inhibitors,

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molinspirations

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molinspirations program.The

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program.The

moderate

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moderate biological

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biological activity

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activity

pharmacophore,

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pharmacophore, in

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in particular

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particular as

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as an

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an

eywords:

ICET

eywords: N-(salicylidene)aniline

ICET

N-(salicylidene)aniline

Cat

Cat room

Croom

P21/n

CP21/n with

Cwith unit

Cunit

,� = 90.00 C,� = 90.00 ,V= 1109.4(13) C ,V= 1109.4(13)

and Cand refined Crefined with Cwith

(Log C(Log PCP, C, P, PCP, P TPSACTPSA

Sknow

Sknow the

Sthe

of

Sof the

Sthe title

Stitle compound

Scompound

room Sroom temperature. Stemperature.

unit Sunit cell Scell parameters Sparameters

,V= 1109.4(13) S ,V= 1109.4(13)

-201

7group.These

-201

7group.These

reported

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7reported by

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7by Hugo

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7Hugo

widely

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fields

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targeting.

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the

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used

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structure -201

7structure is -2

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7

compound

Electrochemical and corrosion studies of az31 magnesium alloy in chloride and sulphate medium

1 1*M. Gururaj Acharya and A. Nityananda Shetty

Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Srinivas nagar-575025


AZ31 magnesium alloy is one of the most common wrought alloys that can be used in vast applications in

numerous fields. AZ31 alloy has similar hot deep-drawing characteristics as magnesium, steel and

aluminum. But, it is highly susceptible to corrosion that limits its potential applications. In the present study, it

has been attempted to comprehend the corrosion behavior of AZ31 alloy using electrochemical techniques

in aqueous salt solutions of sodium chloride, over an altering range of solution temperatures and electrolyte

concentrations. The morphologies of the un-corroded and corroded surfaces have been compared through

their scanning electron microscopy (SEM) images. The results indicate that rate of corrosion increases with

increasing temperature and electrolyte concentration. The kinetic parameters for the corrosion of the alloy

have been evaluated.

Keywords: Magnesium alloy; AZ31 alloy; SEM

Amelioration of the electrochemical performances of the reduced graphene oxide/nickel oxide/ polyaniline nanocomposite

by combination of electrolytesAranganathan Viswanathan and Adka Nityananda Shetty

National institute of technology Karnataka, Surathkal, Srinivasa nagar-post, Mangalore-575025.E-mail Id: [email protected] and [email protected]

Reduced graphene oxide/ nickel oxide/ polyaniline (GNP) nano composite was synthesized by facile

insitu single step chemical method and the structure was characterized by powder-XRD, FT-IR

spectroscopy, scanning electron microscopy (SEM) and electron dispersive analysis (EDS). Its

electrochemical performances were studied in 0.4 M H2SO4 and a mixture of 0.4 M H2SO4/ 0.4 M CH3HSO4

by cyclic voltammetry (CV), galvanostatic charge/discharge (GCD) and electrochemical impedance

spectroscopy (EIS). The amelioration of electrochemical results were observed for a mixture of 0.4 M H2SO4 �/ 0.4 M CH3HSO4 (1:1). The composite showed, specific capacitance of 102.00 Fg 1, energy density of

� �20.38 W h kg 1, power density of 1903.19 Wkg 1, and columbic efficiency of 90.49 % at a current density �of 0.25 A g 1. The enhancement of electrochemical properties from 4 M H2SO4 to mixture of 0.4 M H2SO4/

0.4 M CH3HSO4 , was found to be 41 %.

Keywords: supercapacitors; mixture of electrolytes; specific capacitance; energy and power densities.

OP-12

OP-13

31

ICET

by combination of electrolytes

ICET

by combination of electrolytesAranganathan V

ICET

Aranganathan Viswanathan and Adka Nityananda Shetty

ICET

iswanathan and Adka Nityananda Shetty

National institute of technology Karnataka, Surathkal, Srinivasa nagar

ICETNational institute of technology Karnataka, Surathkal, Srinivasa nagar

E-mail Id: [email protected] and [email protected]

ICETE-mail Id: [email protected] and [email protected]

oxide/

ICET

oxide/ nickel

ICET

nickel oxide/

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oxide/

p

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p c

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ch

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he

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em

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mi

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, s

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tr

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ro

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electrochemical

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electrochemical performances

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performances were

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were

cyclic ICET

cyclic voltammetry ICET

voltammetry (CV), ICET

(CV),

spectroscopy ICET

spectroscopy (EIS). ICET

(EIS). The ICET

The ICET

/ 0.4 M CH3HSO4 (1:1). The composite showed, specific capacitance of 102.00 Fg ICET

/ 0.4 M CH3HSO4 (1:1). The composite showed, specific capacitance of 102.00 Fg

CAmelioration of the electrochemical performances of the reduced

CAmelioration of the electrochemical performances of the reduced

graphene oxide/nickel oxide/ polyaniline nanocomposite

Cgraphene oxide/nickel oxide/ polyaniline nanocomposite

by combination of electrolytesCby combination of electrolytesiswanathan and Adka Nityananda ShettyCiswanathan and Adka Nityananda Shetty

National institute of technology Karnataka, Surathkal, Srinivasa nagarCNational institute of technology Karnataka, Surathkal, Srinivasa nagar

SAmelioration of the electrochemical performances of the reduced SAmelioration of the electrochemical performances of the reduced graphene oxide/nickel oxide/ polyaniline nanocomposite Sgraphene oxide/nickel oxide/ polyaniline nanocomposite

by combination of electrolytesS

by combination of electrolytes

-201

7magnesium,

-201

7magnesium,

applications.

-201

7applications. In

-201

7In the

-201

7the present

-201

7present

electrochemical

-201

7electrochemical techniques

-201

7techniques

solution

-201

7solution temperatures

-201

7temperatures and

-201

7and

surfaces

-201

7surfaces have

-201

7have been

-201

7been compared

-201

7compared

indicate

-201

7indicate that

-201

7that rate

-201

7rate of

-201

7of corrosion

-201

7corrosion

kinetic

-201

7kinetic parameters

-201

7parameters for

-201

7for the

-201

7the

Polyelectrolyte-dye interactions: effect of dye structure on metachromasy

a bNandini R , and Vishalakshi B

aDepartment of Chemistry, MITE, Moodabidri-574 226 (DK), Karnataka, India.b Department of PG studies and Research in Chemistry, Mangalore university.

The interaction of two cationic dyes, namely, Toluidine blue (TB) and Pinacyanol chloride (Pcyn) with an

anionic polyelectrolyte, namely, sodium alginate (NaAlg) has been investigated by spectrophotometric

method. The polymer induced metachromasy in the dyes resulting in the shift of the absorption maxima of

the dyes towards shorter wavelengths. The stability of the complexes formed between Toluidine blue and

sodium alginate was found to be lesser than that formed between Pinacyanol chloride and sodium alginate.

This fact was further confirmed by reversal studies using alcohols, urea and electrolytes. The interaction

parameters revealed that binding between Toluidine blue and sodium alginate was mainly due to

electrostatic forces, while that between Pinacyanol chloride and sodium alginate is found to involve both

electrostatic and hydrophobic forces. The structure of the dye affects the met achromatic shift and other

interaction parameters. Among the two dyes, Pinacyanol chloride being larger in size is more hydrophobic

and hence induces greater aggregation when compared to Toluidine blue, a rigid planar cationic dye. The

extent of metcahromatic shift was found to be 102nm for Pinacyanol chloride-sodium alginate complex and

90 nm forToluidineblue-sodiumalginate complex. Also the interaction constants for Pinacyanol chloride-

sodiumalginatewas found to be greater than for Toluidine blue- sodium alginate in the temperature range

from 309K-327K.

Key words: Cationic dyes; metachromasy; polyelectrolyte; dyestructure; aggregation.

Brain delivery of a model hydrophilic drug using amino acid grafted chitosan nanoparticles

1 1 2 1Vivek Ghate M. , Jessica Fernandes , Sanchari Basu Mallik , Shaila A. Lewis

1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Madhavnagar, Manipal – 576104;

Email: [email protected]; [email protected]; [email protected] of Pharmacology, Manipal College of Pharmaceutical Sciences,

Manipal University, Madhavnagar, Manipal – 576104;Email: [email protected]

Several of the drugs indicated for the mitigation of the brain disorders are hydrophilic and thus impermeable

through the blood brain barrier (BBB). The present research work involved the preparation of an amino-acid

grafted chitosan nanoparticles loaded with Saxagliptin for the transport to the brain cells via the large amino

acid transporter-1 (LAT-1) receptor known to be expressed heavily at the BBB. Saxagliptin was chosen as the

model molecule in the study as it has been recently indicated for the treatment of Alzheimer's disease and is

extremely hydrophilic in nature thus unable to cross the BBB. Methods: Chitosan polymers were

synthesized by carbodiimide chemistry approach using L-valine as the amino acids in the presence of 1-

Ethyl- 3-(3-dimethylamino propyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The

characterization of the polymer was done by NMR and FTIR spectral analysis. Chitosan nanoparticles

loaded with Saxagliptin were then prepared using the synthesized polymer by ionic gelation method and

OP-14

OP-15

32

ICET

metachromasy;

ICET

metachromasy;

Brain delivery of a model hydrophilic drug using

ICETBrain delivery of a model hydrophilic drug using

amino acid grafted chitosan nanoparticles

ICETamino acid grafted chitosan nanoparticles

1

ICET1

ivek Ghate M.

ICETivek Ghate M. , Jessica F

ICET, Jessica Fernandes

ICETernandes

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences,

ICET

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University

ICET

Manipal UniversityEmail: [email protected]; [email protected]; [email protected]

ICET

Email: [email protected]; [email protected]; [email protected]

ICET

2Department of Pharmacology

ICET

Department of PharmacologyManipal University ICET

Manipal University ICET

drugs ICET

drugs

Cfor

Cfor T

CT

metachromasy; Cmetachromasy; polyelectrolyte; Cpolyelectrolyte;

Brain delivery of a model hydrophilic drug using CBrain delivery of a model hydrophilic drug using

Scompared

Scompared

102nm

S102nm for

Sfor Pinacyanol

SPinacyanol

complex.

Scomplex. Also

SAlso the

Sthe interaction

Sinteraction

oluidine Soluidine blue- Sblue- sodium Ssodium

polyelectrolyte; S

polyelectrolyte;

-201

7absorption

-201

7absorption

between

-201

7between T

-201

7Toluidine

-201

7oluidine Toluidine T

-201

7Toluidine T

chloride

-201

7chloride and

-201

7and sodium

-201

7sodium

and

-201

7and electrolytes.

-201

7electrolytes. The

-201

7The

sodium

-201

7sodium alginate

-201

7alginate was

-201

7was

sodium

-201

7sodium alginate

-201

7alginate is

-201

7is found

-201

7found

affects

-201

7affects the

-201

7the met

-201

7met achromatic

-201

7achromatic

chloride

-201

7chloride being

-201

7being larger

-201

7larger in

-201

7in

to -201

7to T -2

017

Toluidine -201

7oluidine Toluidine T -2

017

Toluidine T blue, -201

7blue, a -201

7a

Pinacyanol -201

7Pinacyanol chloride-sodium -2

017

chloride-sodium

interaction -201

7

interaction

1 1 2Eswara Rao M , Sreejit Nair , and S Harish Kumar

1 2SABIC Research and Technology Pvt. Ltd, Bangalore - 562125Manipal University, Manipal – 576104

Conversion of saturated C1 –C6 molecules into valuable chemicals such as olefins and aromatics is a field of

study from 1850 (Hagen, et al., 2000). This paper presents the thermodynamic feasibility analysis of

unsaturated C1 –C6molecules to aromatic compounds mainly focusing on benzene, toluene and xylene

using Gibbs free energy minimization approach. The feasible design space is established for the conversion

of C1-C6 molecules to aromatics. The results indicate that the energy barrier for formation of aromatics

decreases with the increase in the carbon number and the reactions are equilibrium driven and is limited by

thermodynamics. Effect of hydrogen co feeding is alsco established on the thermodynamics of the

reactions. The results indicate that the temperatures range to work on the aromatization are -C1 (700 -900

oC) C2 (400 – 600 oC) C3 – C6 (250-450 oC). Increasing pressure has a negative effect on the equilibrium

and it is advised to keep the operating pressures in the range of 1-5 bara. Further, the selectivity of the

products is analyzed and the results indicate that C2-C6 molecules conversion favors formation of methane

followed by benzene and naphthalene. This gives direction for the catalyst research for minimization of

methane. Coke formation is not taken into consideration during the analysis, as formation of coke is a

kinetically driven reaction. (Bijani, et al., 2012) This analysis will help in design and selection of catalysts

components and fixing design space of temperature and pressure for economical conversions on

commercial scale.

Keywords: Chemical equilibrium, Aromatization, Free energy minimization.

Thermodynamic analysis of c1 – c6 molecules aromotization under non-oxidative conditions

evaluated for particle size and Zeta potential, SEM and FTIR. They were studied for the in vitro stability in both

plasma and brain homogenates. The in vivo performance test of the delivery system in transporting

Saxagliptin into the brain was carried out in female Wistar rats quantified by HPLC. The NMR and FTIR

analysis results showed the successful grafting of the L-valine onto chitosan. The nanoparticles had a

particle size of 741±23 nm (PDI 0.414±0.131) and a surface charge of -1.44 ±0.21 mV. Entrapment was

about 41±12 %. The polymeric system was stable in the plasma for 12 hours and degraded in the brain

homogenate to release the entrapped drug. During the in vivo study in the rats, the L-valine grafted

formulation showed accumulation of Saxagliptin to an extent of 53±11 ng/ml and non-grafted particles

showed 14.58±13.14 ng/ml at the end of 24 hours whereas the pure drug showed no detectable amount in

the brain. The results show that the chitosan-amino acid based polymer was able to deliver Saxagliptin to the

brain via the LAT1 and can be explored further for efficient drug delivery to treat various brain disorders.

Keywords: Chitosan; Brain delivery; Polymer; Amino acids.

OP-16

33

ICET2000).

ICET2000).

aromatic

ICETaromatic compounds

ICET

compounds

minimization

ICETminimization approach.

ICETapproach.

aromatics.

ICETaromatics. The

ICETThe results

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ICETindicate

increase

ICETincrease in

ICETin the

ICETthe carbon

ICETcarbon number

ICETnumber

Effect

ICET

Effect of

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of hydrogen

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hydrogen co

ICET

co

results

ICET

results indicate

ICET

indicate that

ICET

that the

ICET

the

–

ICET

– 600

ICET

600 oC)

ICET

oC) C3

ICET

C3 –

ICET

– C6

ICET

C6 (250-450

ICET

(250-450

advised

ICET

advised to

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to keep

ICET

keep the

ICET

the operating

ICET

operating

products ICET

products is ICET

is analyzed ICET

analyzed and ICET

and the ICET

the

benzene ICET

benzene and ICET

and

Coke ICET

Coke formation ICET

formation

CManipal University

CManipal University

molecules

Cmolecules into

Cinto valuable

Cvaluable

2000). C2000). This CThis paper Cpaper presents Cpresents

aromatic Caromatic compounds Ccompounds

approach. Capproach. The CThe

S1

S1

, Sreejit Nair

S, Sreejit Nair , and S Harish K

S, and S Harish K

echnology Pvt. Ltd, Bangalore - 562125

Sechnology Pvt. Ltd, Bangalore - 562125

Manipal University SManipal University, Manipal – 576104S, Manipal – 576104

valuable Svaluable chemicals Schemicals

presents Spresents

-201

7, and S Harish K-2

017

, and S Harish K

echnology Pvt. Ltd, Bangalore - 562125-201

7

echnology Pvt. Ltd, Bangalore - 562125, Manipal – 576104-2

017

, Manipal – 576104

Thermodynamic analysis of c1 – c6 molecules aromotization under

-201

7Thermodynamic analysis of c1 – c6 molecules aromotization under

non-oxidative conditions

-201

7non-oxidative conditions

detectable

-201

7detectable

deliver

-201

7deliver Saxagliptin

-201

7Saxagliptin

various

-201

7various brain

-201

7brain disorders.

-201

7disorders.

Magnetically recoverable core-shell Au@Ni/rGO nanocomposites as active photocatalyst

1,2 1,2*G. Darabdhara and Manash R. Das

1Advanced Materials Group, Materials Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India

2Academy of Scientific and Innovative Research, CSIR-NEIST Campus, IndiaE-mail: [email protected]

Phenol and its derivatives have been identified since 1976 by the US Environment Protection Agency

(USEPA)1 as highest priority water pollutants and are found in wastewaters of petroleum refineries, plastic

manufacturing, coal conversion plants, etc. Stability, solubility, toxicity, carcinogenicity etc. are the risk

associated with these pollutants and thus they possess threat to the ecosystem in water bodies and human

health. Accordingly, development of strategies for their elimination is of crucial demand. Amongst the

processes, the use of photocatalytic technique seems to be a promising route for efficient oxidative

decomposition of phenol wastewater. A number of semiconductor materials such as TiO2, ZnO, etc. has

been reported for photocatalytic degradation of phenolic compounds but are limited by the high

recombination rate of light-induced electron-hole pairs at the photocatalyst surface.2 However, requirement

for designing new and innovative photocatalyst is still the quest of researchers all over the globe.

Considering this aspect, we developed a novel and a magnetically recoverable photocatalyst of bimetallic

core-shell Au@Ni nanoparticles (NPs) on reduced graphene oxide (rGO) sheets for the degradation of

phenol, 2-chlorophenol and 2-nitrophenol under sunlight irradiation. Bimetallic NPs are interesting because

of their enhanced physical and chemical properties due to the synergistic effect of the two components.

Additionally, core shell NPs are attracting because of their unique optical, electrical and catalytic properties

in comparison to their monometallic counterparts and alloys. Ni demonstrates remarkable magnetic

properties both in bulk as well as nano range.3 Thus, synthesizing bimetallic NPs comprising magnetic Ni as

one of the constituents is a key step for certain targeted applications demanding recovery and recycling.

Motivated by this and considering the importance of Au nanoparticles in different application we developed

a photocatalyst comprising of both Ni and Au in the form of core shell nanostructure on rGO nanosheets by a

simple solvothermal reduction technique. The material was characterized by XRD, HRTEM, FESEM, EDX,

FT-IR etc. Excellent degradation above 90 % was recorded for all the three phenolic compounds under

natural sunlight irradiation. The catalyst was successfully recovered up to six continuous cycles and reused.

Thus, this study provides a facile direction for developing new and sustainable photocatalytic materials with

a view of environment remediation.

Keywords: gold-nickel bimetallic nanoparticles; photocatalytic degradation; phenolic compounds

OP-17

34

ICET

attracting

ICET

attracting

monometallic

ICET

monometallic counterparts

ICET

counterparts

as

ICETas nano

ICETnano range.3

ICETrange.3 Thus,

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a

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considering

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comprising

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comprising of

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of both

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both Ni

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Ni and

ICET

and

simple solvothermal reduction technique. The material was characterized by XRD

ICET

simple solvothermal reduction technique. The material was characterized by XRD

Excellent

ICET

Excellent degradation

ICET

degradation

sunlight

ICET

sunlight

ICET

irradiation.

ICET

irradiation. The

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The

this ICET

this study ICET

study provides ICET

provides a ICET

a

environment ICET

environment remediation. ICET

remediation.

gold-nickel ICET

gold-nickel

Cunder

Cunder sunlight

Csunlight

chemical

Cchemical properties

Cproperties due

Cdue

attracting Cattracting because Cbecause of Cof their Ctheir

counterparts Ccounterparts and Cand

Thus, CThus,

Sstill

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a

Sa magnetically

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Sreduced graphene

Sgraphene

sunlight Ssunlight irradiation. Sirradiation.

due Sdue to Sto the Sthe

unique Sunique

-201

7petroleum

-201

7petroleum refineries,

-201

7refineries,

carcinogenicity

-201

7carcinogenicity etc.

-201

7etc. are

-201

7are

ecosystem

-201

7ecosystem in

-201

7in water

-201

7water bodies

-201

7bodies and

-201

7and

of

-201

7of crucial

-201

7crucial demand.

-201

7demand. Amongst

-201

7Amongst

promising

-201

7promising route

-201

7route for

-201

7for efficient

-201

7efficient

semiconductor

-201

7semiconductor materials

-201

7materials such

-201

7such as

-201

7as T

-201

7T

compounds

-201

7compounds but

-201

7but are

-201

7are

the

-201

7the photocatalyst

-201

7photocatalyst surface.2

-201

7surface.2

still -201

7still the -2

017

the quest -201

7quest of -2

017

of researchers -201

7researchers

magnetically -201

7magnetically recoverable -2

017

recoverable

oxide -201

7

oxide

A simple, Precise, Accurate and rapid reverse phase high performance liquid chromatography method has

been developed for the estimation of Enzalutamide drug substance by using Zorbax SB phenyl (250mm×

4.6mm, 3µ) column. The Isocratic mode of elution was developed. The mobile phase A was 5.0 grams of

Ammonium Acetate in water and the pH 4.2 was adjusted with Trifluoracetic acid and the mobile phase B

was Acetonitrile. The diluent was Acetonitrile. The mobile phase was prepared in the ratio of (45:55 v/v)

(Mobile phase A & B) by maintaining a flow rate of 1.0ml per minute at ambient temperature. The wavelength

was fixed at 280nm in UV-Vis detector. The Retention time of Enzalutamide was 7.853min. The method was

linear over the concentration range of 0.5 to 1.2mg/ml. The percentage mean recovery for Enzalutamide was

found to be 98% to 102% and the RSD was found to be less than 2%. The proposed method was a new

method of analysis for estimation of Enzalutamide drug substance by RP-HPLC method. And the method

was found to be suitable for the routine analysis of Enzalutamide in pure drug substance.

Keywords: Enzalutamide; Ammonium Acetate; Acetonitrile; Validation.

Synthesis of new series of isoniazid derivatives and their biological evaluation against Mycobacterium tuberculosis in mgit liquid culuture

a cSushruta S. Hakkimane , Vignesh U. N.b, Vishnu Prasad ,

b,*Bharath Raja Gurua and Santosh L. Gaonkar aDepartment of Biotechnology, Manipal Institute of Technology (MIT),

Manipal University, Manipal, IndiabDepartment of Chemistry, Manipal Institute of technology (MIT),

Manipal University, Manipal, IndiacDepartment of Microbiology, Kasturba Medical College (KMC),

Manipal University, Manipal, India Email:[email protected]

Isoniazid (INH), is a widely used drug in the treatment of tuberculosis. Isoniazid act as a prodrug and is

activated invivo by hydrolysis. Isoniazid derivatives are reactive species affect the respiratory system of

bacteria and inhibit the synthesis of cell wall lipid.1 Isoniazid stands as a crucial element in all multiple drug

treatment for tuberculosis suggested by the WHO. Modified drugs are gaining interest in recent years due to

the increasing number of multi-drug resistant strains leading to treatment failure. Insertion of lipophilic

moiety to isoniazid increases the interaction of drug molecule with the bacterial cell there by improving the

anti-TB activity.2 Prompted by these, and in continuation to our work on the synthesis of biologically active

heterocycles, we have synthesized new library of isoniazid derivatives. The synthesized compounds are

characterized by modern analytical techniques and evaluated for their anti-tubercular activities. Some of the

synthesized compounds exhibited potent anti-tubercular activity. Using Mycobacteria Growth Indicator

Tube (MGIT) 960 on a BACTEC system, antimicrobial susceptibility testing (AST) of Mycobacterium

tuberculosis was tested for susceptibility to critical concentrations of isoniazid (INH) as recommended.

Keywords: Isoniazid, Isoniazid hydrazones, Anti-tubercular agents.

Method development and validation of Enzalutamide pure drug substance by using liquid chromatographic technique

1 2J. Sandya Rani and N. Devanna1Department of chemistry, Jawaharlal Nehru Technological university

Anantapur, Andhrapradhesh E-mail Id: [email protected] of chemistry, Jawaharlal Nehru Technological university

Anantapur, Andhrapradhesh E-mail Id: [email protected]

OP-18

OP-19

35

ICET

Precise, ICET

Precise, Accurate ICET

Accurate

for ICET

for

susceptibility

ICET

susceptibility

hydrazones,

ICET

hydrazones,

Method development and validation of Enzalutamide pure drug

ICETMethod development and validation of Enzalutamide pure drug

substance by using liquid chromatographic technique

ICETsubstance by using liquid chromatographic techniqueJ

ICETJ. Sandya Rani

ICET

. Sandya Rani1

ICET

1Department of chemistry

ICET

Department of chemistryAnantapur

ICET

Anantapur, Andhrapradhesh E

ICET

, Andhrapradhesh E1

ICET

1Department of chemistry

ICET

Department of chemistryAnantapur IC

ETAnantapur

Canti-tubercular

Canti-tubercular

system,

Csystem, antimicrobial

Cantimicrobial

susceptibility Csusceptibility to Cto critical Ccritical concentrations Cconcentrations

hydrazones, Chydrazones, Anti-tubercular CAnti-tubercular

Sisoniazid

Sisoniazid

and

Sand evaluated

Sevaluated for

Sfor

anti-tubercular Santi-tubercular activitySactivity

antimicrobial Santimicrobial susceptibility Ssusceptibility

concentrations Sconcentrations

-201

7, Kasturba Medical College (KMC),

-201

7, Kasturba Medical College (KMC),

, Manipal, India Email:[email protected]

-201

7, Manipal, India Email:[email protected]

Isoniazid

-201

7Isoniazid act

-201

7act as

-201

7as a

-201

7a prodrug

-201

7prodrug

affect

-201

7affect the

-201

7the respiratory

-201

7respiratory

a

-201

7a crucial

-201

7crucial element

-201

7element in

-201

7in all

-201

7all

are

-201

7are gaining

-201

7gaining interest

-201

7interest in

-201

7in

to

-201

7to treatment

-201

7treatment failure.

-201

7failure.

molecule

-201

7molecule with

-201

7with the

-201

7the bacterial

-201

7bacterial cell

-201

7cell

to -201

7to our -2

017

our work -201

7work on -2

017

on the -201

7the synthesis -201

7synthesis

isoniazid -201

7isoniazid derivatives. -2

017

derivatives. The -201

7The

for -201

7

for their -201

7

their

Temperature dependent reversible dynamics in SinC (n=3-9) binary nanoclusters: A BOMD study

$1 1*Mohammed Azeezulla Nazrulla and Sailaja Krishnamurty1 Functional Materials Division, CSIR-CECRI, Karaikudi-630 003

$ Academy of Scientific and Innovative Research, New Delhi, India* Corresponding author E-mail ID: [email protected] author E-mail ID: [email protected]

Comprehension of geometric and electronic properties of the SiC binary nanoclusters (BNCs) play a pivotal

role in the development of nano-assemblies for micro-and nano-electronic devices, catalysis and so on.

These BNCs are of also significant importance from the fundamental point of view as these have been found

in the interstellar medium. Atomic engineering of these BNCs leads to fascinating physico-chemical

properties1 of great interest alongside the contemporary works on (noble)metal clusters. A more recent

direct observation of reversible dynamics in Si6 cluster embedded within a graphene pore, adds additional

impetus to understand the temperature dependent intrinsic properties of the pristine and doped/alloyed

clusters.2 Driven by these experiments and also our preliminary work on sequential doping of Si clusters

with C,3 herein we address the influence of critical ratio of C in Si clusters with respect to thermal stability

using BOMD simulations. In addition, we also explore the reversible dynamic pathways, co-existence of

isomers, and fragmentation channels for SinC (n=3-9) from 200 to 3000 K using Nose-Hoover thermostat

under NVT ensemble. At each temperature, the cluster is equilibrated for a time period of 10 ps and a total

simulation of 80 ps. Velocity-Verlet algorithm has been used to update the nuclear positions with a time step

of 1fs. All the calculations are performed using density functional theory using linear combination of

Gaussian orbitals as implemented in deMon2K suite of program. The atomic positions and bond length

fluctuations of atoms are analyzed using traditional parameters such as root mean squared bond length

fluctuations (�rms) and the Mean Squared Ionic Displacement (MSD). Replacing a Si atom by C atom leads

to presence of strong Si-C bonding, thereby enhances the thermal stability of BNCs compared to the pristine

Si clusters.

Keywords: Binary clusters; Reversible dynamics; Born-Oppenheimer Molecular Dynamics (BOMD);

Density Functional Theory.

OP-20

36

ICET

in

ICET

in deMon2K

ICET

deMon2K

analyzed

ICET

analyzed using

ICET

using traditional

ICET

traditional

Mean

ICETMean Squared

ICETSquared Ionic

ICETIonic Displacement

ICETDisplacement

bonding,

ICETbonding, thereby

ICETthereby enhances

ICETenhances

Binary

ICET

Binary clusters;

ICET

clusters; Reversible

ICET

Reversible

unctional

ICET

unctional Theory

ICET

Theory.

ICET

.

Chas

Chas been

Cbeen

performed

Cperformed using

Cusing density

Cdensity

deMon2K CdeMon2K suite Csuite of Cof

traditional Ctraditional parameters Cparameters

Ionic CIonic Displacement CDisplacement

Sexplore

Sexplore the

Sthe

(n=3-9)

S(n=3-9) from

Sfrom

cluster

Scluster is

Sis equilibrated

Sequilibrated

been Sbeen used Sused to Sto update Supdate

density Sdensity functional Sfunctional

-201

7(BNCs)

-201

7(BNCs)

devices,

-201

7devices, catalysis

-201

7catalysis

as

-201

7as these

-201

7these have

-201

7have been

-201

7been

fascinating

-201

7fascinating physico-chemical

-201

7physico-chemical

(noble)metal

-201

7(noble)metal clusters.

-201

7clusters. A

-201

7A

within

-201

7within a

-201

7a graphene

-201

7graphene pore,

-201

7pore,

properties

-201

7properties of

-201

7of the

-201

7the pristine

-201

7pristine

preliminary

-201

7preliminary work

-201

7work on

-201

7on sequential

-201

7sequential

with C,3 herein we address the influence of critical ratio of C in Si clusters with respect to thermal stability

-201

7with C,3 herein we address the influence of critical ratio of C in Si clusters with respect to thermal stability

the -201

7the reversible -2

017

reversible dynamic -201

7dynamic

200 -201

7200 to -2

017

to 3000 -201

73000

equilibrated -201

7

equilibrated

Synthesis and characterisation of biologically important (E)-1-(2-chloro/hydroxy-6/8-substituted quinolin-3-yl)-N-[5-(4-substitued

phenyl)-1,3,4-thiadiazol-2-yl]methanimines1 2

Vineetha Telma D'Souza and Janardhana Nayak1Deparment of Chemistry, M.I.T.E., Moodabidri-574 225, E-mail: [email protected]

2Deparment of Chemistry, N.M.A.M. I.T, Nitte-574 110, E-mail: [email protected]

A new series of (E)-1-(2-chloro/hydroxy-6/8-substituted quinolin-3-yl)-N-[5-(4-substitued phenyl)-1,3,4-

thiadiazol-2-yl]methanimine derivatives were synthesized by the condensation of 5-(4-substituted phenyl)-

1,3,4-thiadiazole-2-amine with 6/8-substituted-2-chloroquinoline-3-carbaldehyde and 6/8-substituted-2-

hydroxy quinoline-3-carbaldehyde. The novel compounds were characterized by Mass, NMR and IR

spectroscopy. The synthesized compounds were screened for their antibacterial and antifungal activities.

Among them few of the novel compounds showed biological activities comparable with that of standard

drug.

Keywords: Thiosemicarbazide, Thiadiazole, Antibacterial, Antifungal.

Charge-carrier injection, charge-carrier transport, electro-hole recombination of organic semiconductors

plays an important role in the efficiency of an organic light emitting diodes (OLED). Here we report the nature

of charge-carrier transport mechanism in π-stacking organic semiconductor, 2-(4-tert-butylphenyl)-5-

(pyren-1-yl)-1,3,4-oxadiazole (TBUT) based electron-only device configuration as a function of temperature

and organic layer thickness. Temperature dependent electrical measurements (160-320 K) infer that low

voltage regimes are governed by ohmic conduction and trap-charge limited conduction (TCLC) with

exponential distribution of traps, whereas trap-free space-charge limited conduction (SCLC) is observed at

higher voltages. Poole–Frenkel model is used to calculate the effective mobility, which exhibits thermally

activated behaviour. The estimated trap densities and trap energies show thickness dependence. Further,

inserting a thin layer of TBUT as an electron transport material has a more dominant role in improving the

performance of the OLED.

Keywords: Pyrene, OLEDs, Mobility, Charge-carrier

OP-21

37

ICETcharge-carrier

ICETcharge-carrier transport,

ICETtransport,

the

ICETthe efficiency

ICETefficiency of

ICETof an

ICETan organic

ICETorganic

transport

ICETtransport mechanism

ICETmechanism in

ICETin π-stacking

ICETπ-stacking

(pyren-1-yl)-1,3,4-oxadiazole

ICET

(pyren-1-yl)-1,3,4-oxadiazole (TBUT)

ICET

(TBUT) based

ICET

based

layer

ICET

layer thickness.

ICET

thickness. T

ICET

Temperature

ICET

emperature Temperature T

ICET

Temperature T

regimes

ICET

regimes are

ICET

are governed

ICET

governed by

ICETby

exponential

ICET

exponential distribution

ICET

distribution of

ICET

of traps,

ICET

traps,

voltages. ICET

voltages. P ICET

Poole–F ICET

oole–Frenkel ICET

renkel ICET

behaviour ICET

behaviour. ICET

. The ICET

The

inserting a thin layer of TBUT as an electron transport material has a more dominant role in improving the ICET

inserting a thin layer of TBUT as an electron transport material has a more dominant role in improving the

Ctransport, Ctransport, electro-hole Celectro-hole

S-201

75-(4-substituted

-201

75-(4-substituted

6/8-substituted-2-chloroquinoline-3-carbaldehyde

-201

76/8-substituted-2-chloroquinoline-3-carbaldehyde and

-201

7and 6/8-substituted-2-

-201

76/8-substituted-2-

characterized

-201

7characterized by

-201

7by Mass,

-201

7Mass, NMR

-201

7NMR

antibacterial

-201

7antibacterial and

-201

7and antifungal

-201

7antifungal

comparable

-201

7comparable with

-201

7with that

-201

7that

Antifungal.

-201

7Antifungal.

Investigation of 2-(4-tert-butylphenyl)-5-(pyren-1-yl)-1,3,4-oxadiazole as an electron transport material in organic light-emitting Diodes

1* 2 2Hidayath Ulla , M. Raveendra Kiran , and M. N. Satyanarayan

1 Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India2 Department of Physics, National Institute of Technology Karnataka, Mangalore 575025, India

* [email protected]

OP-22

Method For Qualitative And Quantitative Analysis of Fire Retardant Fabric

R G Revaiah & T M Kotresh

Defence Bioengineering and Electromedical Laboratory, C V Raman Nagar,Bengaluru – 560093 India

Nomex IIIA (NIIIA) is the most commonly used Fire Resist/Retardant (FR) fabric by military, para military,

fighter pilots, industrial workers, etc. Several billion dollars worth industries in the World thrive on the

manufacture of FR fabric It is the blend of polymetaphenylene isophthalimide or Nomex (93%),

polyparaphenylene terephthalimide or Kevlar (5%) and polyhexamethylene adipamide, or Nylon (2%).

However, components ratio largely decides FR properties and hence the protection levels. Due to inherent

problems associated with separation of individual components, there is no reported un-ambiguous method

of confirmatory tests in the literature for analysis of this blend. Further, it is also imperative to know

composition as well as distribution of the components in the given fabric matrix.

In the present study, a new method was developed where the Nylon content was extracted from NIIIA fabric

using 90% formic acid and the Nomex content was extracted using dimethyl acetamide (DMAc) containing

4% lithium chloride by Sonication at 80°C and remaining insoluble content was taken as kevlar. Weight of

each component was determined by gravimetric analysis. The chemical composition of the nomex III A

blend was found to be 93% of Nomex, 5% of Kevlar and 2% of nylon. Further, the separated Nomex and

Kevlar fractions were characterized by TGA and FTIR analyses and the results were compared with available

standards.

Keywords: Blend analysis, Nomex IIIA, Kevlar, Nylon, Sonication, TGA, FTIR

Exploring the binding interactions of antibiotic/anticancer drugs with DNA turn out to be a dynamic field of

research at the interface between biological science and medicinal chemistry. The interaction of

aminoglycoside drug kanamycin with calf thymus DNA was studied by using spectroscopic and calorimetric

studies. In this work, we have tried to find out the binding mode of kanamycin with ctDNA under physiological

pH using spectroscopic and thermodynamic techniques. Isothermal Titration Calorimetry (ITC) studies

suggest that the binding is enthalpically favored with a small entropic change and a binding constant of the

order of 104, which remains almost same in the studied temperature range. Experiments were done in the

presence of osmolytes tetraehtylene glycol and sucrose to see the affect of altered water activity on the

binding. No appreciable change in the binding behavior as well as on the stability of the DNA-kanamycin

complex was observed, which suggests that the number of water molecule released or uptaken is not

significant in the binding process. No appreciable change in the binding affinity was observed in the pH

range of 7.0 to 9.0. Competitive fluorescence studies with DNA ethidium bromide and circular dichroism

studies show that kanamycin follows groove binding mode of interaction. Thermal denaturation studies

show that there is a 5 K stabilization of DNA at 1:10 DNA to drug molar ratio.

Key words: kanamycin; calf thymus DNA; Isothermal titration Calorimetry; groove binding

OP-23

38

ICET

,

ICET

,

Exploring

ICET

Exploring the

ICET

the binding

ICET

binding interactions

ICET

interactions

a ICET

at ICET

t t ICET

th ICET

he ICET

e i ICET

in ICET

nt ICET

te ICET

er ICET

rf ICET

fa ICET

ac ICET

ce ICET

e

aminoglycoside ICET

aminoglycoside drug ICET

drug kanamycin ICET

kanamycin ICET

work, ICET

work,

CF

CF

K

CKevlar

Cevlar,

C, Nylon,

CNylon, Sonication,

CSonication, S

analysis.

Sanalysis.

evlar

Sevlar and

Sand 2%

S2% of

Sof

TIR STIR analyses Sanalyses and Sand

Sonication, SSonication,

-201

7o

-201

7o

adipamide,

-201

7adipamide, or

-201

7or

protection

-201

7protection levels.

-201

7levels. Due

-201

7Due

reported

-201

7reported un-ambiguous

-201

7un-ambiguous

urther

-201

7urther,

-201

7, it

-201

7it is

-201

7is also

-201

7also imperative

-201

7imperative

fabric

-201

7fabric matrix.

-201

7matrix.

Nylon

-201

7Nylon content

-201

7content was

-201

7was extracted

-201

7extracted

using

-201

7using dimethyl

-201

7dimethyl acetamide

-201

7acetamide

4% lithium chloride by Sonication at 80°C and remaining insoluble content was taken as kevlar

-201

74% lithium chloride by Sonication at 80°C and remaining insoluble content was taken as kevlar

analysis. -201

7analysis. The -2

017

The chemical -201

7chemical

of -201

7of nylon. -2

017

nylon.

and -201

7

and the -201

7

the

1 2Neelam Keshwani , and Nand Kishore

1Ramniranjan Jhunjhunwala college (affiliated to Mumbai University), Ghatkopar (W) Mumbai 400086, India

2Indian Institute of Technology Bombay, Powai Mumbai 400076, India

Thermodynamic and spectroscopic studies of interaction of kanamycin with DNA

OP-24

The corrosion inhibitive effect of eco-friendly green inhibitor for aluminium 6063 alloy in 0.5 m hydrochloric acid

1 2 3 4Divya kumari , Reena kumari P.D , A. Nityananda Shetty , and Srinivasan K. K.

1Department of chemistry, Poornaprajna College, Udupi.2&4Department of Chemistry, Shri Madhwa Vadiraja Institute of Technology & Management, Bantakal.

3Department of Chemistry, National Institute of Technology Surathkal, Karnataka.*E-mail:[email protected]

The corrosion inhibition effect of quercetin, a natural bioflavonoid for the corrosion of AA 6063 in 1 M HCl

medium has been evaluated by electrochemical impedance spectroscopy (EIS) and potentiodynamic

polarization (PDP) techniques. The inhibition studies were carried at a temperature range of 30-60 °C. The

inhibition efficiency increased with the increase in the concentration of the inhibitor and also with the

increase in temperature. The surface morphologies of the polished, corroded and inhibited surface were

analysed by recording the scanning electron microscope (SEM) images. The activation parameter like

energy of activation, enthalpy of activation and entropy of activation were calculated and analysed.

Thermodynamic parameters for the adsorption of the inhibitor on the metal alloy surface were calculated

and analysed. The inhibitor acted as a mixed inhibitor. Adsorption of inhibitor on the alloy surface was

preferentially chemisorption, following Langmuir adsorption isotherm. The maximum inhibition efficiency

was found to be 92.1% and 91.45 by PDP and EIS studies, respectively at 60 °C. Quecetin acted as a

promising, highly efficient, low cost and green corrosion inhibitor for the alloy AA 6063 under consideration.

Keywords: Green Inhibitor; Electrochemical studies; Activation and thermodynamic parameters;

chemisorption. SEM;

Polymer electrolyte membranes for fuel cells are attractive option to resolve the energy crisis and

environmental problems because of their high energy density and efficiency. Nowadays, there has been a

growing interest in alkaline fuel cells that utilize anion exchange membranes (AEMs) as an electrolyte

membrane. The existing AEMs are, however, not much conductive and have poor alkaline stability.1 In order

to overcome these shortcomings, we applied a concept of terminal crosslinking to enhance the dimensional

and chemical stability. Recently, we have developed poly(arylene ether sulfone) (PES) containing pendant

imidazole group both as crosslinker and hydroxide conductor.2,3 In this context, we prepared poly(arylene

ether sulfone) containing morpholinium functionality with allyl group at the terminus of the polymer chain.

The bisazide (crosslinker) with the allyl terminal group were responsible for the crosslinking.4 These

membranes were transparent, flexible and insoluble in organic solvents. The terminally crosslinked

membranes displayed increase in thermal, chemical and ionic conductivity. Further details like synthesis,

characterization, dimensional stability, thermochemical stability will be discussed.

Keywords: Anion exchange membranes; Terminal crosslinking; Morpholinium conductor

OP-25

39

ICET

electrolyte

ICET

electrolyte membranes

ICET

membranes

environmental problems because of their high energy density and efficiency ICET

environmental problems because of their high energy density and efficiency

interest ICET

interest ICET

in ICET

in alkaline ICET

alkaline

The ICET

The existing ICET

existing

Ccorrosion

Ccorrosion

m

Cmi

Cic

Cca

Cal

Cl s

Cst

Ctu

Cu S

adsorption

Sadsorption

EIS

SEIS studies,

Sstudies,

corrosion Scorrosion inhibitor Sinhibitor for Sfor

d Sdi Sie SesSs;S; ASAcSctStiSivSv

-201

7AA

-201

7AA

(EIS)

-201

7(EIS) and

-201

7and potentiodynamic

-201

7potentiodynamic

temperature

-201

7temperature range

-201

7range of

-201

7of 30-60

-201

730-60

the

-201

7the inhibitor

-201

7inhibitor and

-201

7and also

-201

7also

corroded

-201

7corroded and

-201

7and inhibited

-201

7inhibited

images.

-201

7images. The

-201

7The activation

-201

7activation

activation

-201

7activation were

-201

7were calculated

-201

7calculated

inhibitor

-201

7inhibitor on

-201

7on the

-201

7the metal

-201

7metal alloy

-201

7alloy surface

-201

7surface

Adsorption

-201

7Adsorption of

-201

7of inhibitor

-201

7inhibitor

adsorption -201

7adsorption isotherm. -2

017

isotherm. The -201

7The

studies, -201

7studies, respectively -2

017

respectively

for -201

7

for the -201

7

the

Anion exchange membranes based on terminally crosslinked methyl morpholinium-functionalized poly(arylene ether sulfone)s

1 2 3Anil H. N. Rao , Sohyun Kwon and Tae-Hyun Kim

1 Department of Chemistry, Siddaganga Institute of Technology, Tumakuru2, 3 Department of Chemistry, Incheon National University, Songdo-Dong, Incheon, Republic of Korea

OP-26

OP-27Catalyst free synthesis of dihydropyrano pyrazole

derivatives using PEG-400

Hemant Hegde, Nitinkumar S. Shetty*

Manipal Institute of Technology, Manipal, Karnataka, India-576104*[email protected]

The use of greener and safe reaction media in place of volatile solvents have been considered as an

essential part of organic synthesis. To address the problems caused by volatile organic solvents, liquid

polymers or low melting polymers are developed as an alternate medium for the organic synthesis. In this

direction, PEG-400 is emerged as an important reaction media due to their thermal stability, non-toxicity,

recyclability, and water solubility. On the other hand, fused pyran derivatives represent promising class of

bicyclic heterocycles which constitute structural unit of many therapeutic agents and natural products.

Pyrano[2, 3-c]pyrazole derivatives are such compounds gained major attention due to their potent

biological activities.

In view of these aspects, a simple and efficient method for the synthesis of dihydropyrano[2, 3-c]pyrazole

derivatives has been attempted. A series of dihydropyrano[2, 3-c]pyrazole derivatives are synthesized

under catalyst free condition using PEG-400 as reaction medium. All the products are characterized using

FTIR, 1H-NMR and 13C-NMR spectroscopic techniques. Efficiency of the method is appreciated by

comparing it with DMAP catalyzed reaction. The protocol facilitated good yield and high selectivity in the

formation of dihydropyrano [2, 3-c] pyrazole derivatives and is found to be as efficient as that of catalyzed

reaction.

OP-28

N Akshatha, and M P Yashoda*.

Department of chemistry, Manipal Institute of Technology, Manipal-576104.*+91-8147-419-027; [email protected]

Synthesis of maleic anhydride water soluble antimicrobial polymers for diverse applications

Abstract: Microbial infections are the major issues in hospital furniture, dental equipment, food packaging

and storage, water purification systems, and household sanitation etc. Antimicrobial polymers represent a

class of biocides that has become increasingly important as an alternative to existing biocides and in some

cases even to antibiotics. As maleic anhydride antimicrobial polymers have wide applications in food

industry, disinfectants, medical devices, wound dressing etc. The present research topic focuses on

synthesis of maleic anhydride polymers for antimicrobial applications. Maleic anhydride antimicrobial

polymers were synthesized by free radical polymerization using solution polymerization technique. The

polymer obtained was characterized by FTIR and NMR. The synthesized maleic anhydride polymer was

tested for antimicrobial activity which can have various applications like in food industry, textile industry,

wound dressing, water purification treatment etc.

Keywords: Maleic anhydride, free radical polymerization, antimicrobial polymer.

40

ICETN Akshatha, and M P Y

ICETN Akshatha, and M P Y

Department of chemistry

ICETDepartment of chemistry, Manipal Institute of T

ICET, Manipal Institute of T

*+91-8147-419-027; [email protected]

ICET

*+91-8147-419-027; [email protected]

Synthesis of maleic anhydride water soluble antimicrobial polymers

ICET

Synthesis of maleic anhydride water soluble antimicrobial polymers for diverse applications

ICETfor diverse applications

Microbial

ICET

Microbial infections

ICET

infections are

ICET

are the

ICETthe

storage,

ICET

storage,

ICET

water

ICET

water purification

ICET

purification

biocides ICET

biocides that ICET

that has ICET

has become ICET

become

to ICET

to ICET

antibiotics. ICET

antibiotics.

disinfectants, ICET

disinfectants,

Cderivatives

Cderivatives

Synthesis of maleic anhydride water soluble antimicrobial polymers CSynthesis of maleic anhydride water soluble antimicrobial polymers for diverse applicationsCfor diverse applications

Stechniques.

Stechniques.

protocol

Sprotocol facilitated

Sfacilitated

derivatives Sderivatives and Sand is Sis found Sfound -2

017

organic

-201

7organic synthesis.

-201

7synthesis.

thermal

-201

7thermal stability

-201

7stability,

-201

7,

. On the other hand, fused pyran derivatives represent promising class of

-201

7. On the other hand, fused pyran derivatives represent promising class of

agents

-201

7agents and

-201

7and natural

-201

7natural

major

-201

7major attention

-201

7attention due

-201

7due to

-201

7to

synthesis

-201

7synthesis of

-201

7of dihydropyrano[2,

-201

7dihydropyrano[2,

dihydropyrano[2,

-201

7dihydropyrano[2, 3-c]pyrazole

-201

73-c]pyrazole derivatives

-201

7derivatives

medium.

-201

7medium. All

-201

7All the

-201

7the products

-201

7products

techniques. -201

7techniques. Efficiency -2

017

Efficiency of -201

7of

facilitated -201

7

facilitated good -201

7

good

found -2

017

found

OP-29

Amberlyst IR 120 mediated synthesis of diverse 3,4-disubstituted isoxazol-5-(4H)-Ones

bMohasim M. Patel , Srinivas L. Nakkalwara, , Shivaji B. Patwaria, *b

and Vivekanand B. JadhavaDepartment of Chemistry, Lal Bahadur Shastri College,

Dharmabad, Dist.-Nanded (MH), India,bDepartment of Chemistry, Shri Muktanand College,

Gangapur, Dist.-Aurangabad, (MH), IndiaE-mail: [email protected]

Abstract: An efficient straightforward one pot three component synthesis of diverse 3,4-disubstituted

isoxazol-5-(4H)-ones is achieved via the reaction of �-oxoesters with hydroxylamine hydrochloride and

various aromatic aldehydes, leading towards excellent yield of products in aqueous medium using

Amberlyst IR 120 as a catalyst. In addition, this particular cyclo-addition reaction was performed in water

which is as an environmentally benign universal solvent i.e. water which is having unique properties like

clean, efficient, inexpensive and readily available green medium fulfilling the earnest need of ecofriendly

approach which is currently the need of time. Isoxazole and their derivatives possesses unique biological as

well as pharmaceutical activities and it is at the forefront of all heterocyclic compounds as leading drug

candidate among various nucleases present in the literature till date.

Keywords: Aromatic Aldehydes; Hydroxylamine hydrochloride; 3, 4-disubstituted isoxazol-5(4H)-ones;

Amberlyst IR 120; Ethyl Acetoacetate.

OP-30Pullulan as an ecofriendly green inhibitor for corrosion

control of 6061-al alloyCharitha B.P and Padmalatha Rao*

Department of Chemistry, Manipal Institute of Technology, Manipal, India*E mail: [email protected]

The corrosion inhibition characteristics of biopolymer pullulan was studied as an ecofriendly inhibitor for the

corrosion control of 6061 aluminum alloy in 0.025 M HCl. Electrochemical methods such as

potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) techniques were

adopted. Effect of inhibitor concentrations (0.2 to 1.0 gL1) was studied at temperatures of 303 to 323 K. The

kinetic and thermodynamic parameters for corrosion and inhibition process were determined. The surface

morphology of aluminum in the absence and presence of pullulan in 0.025 M HCl solution was studied using

Scanning Electron Microscope (SEM) and Electron Dispersive X-Ray spectroscopy (EDX). Suitable

mechanism was proposed for corrosion inhibition process. The percentage inhibition efficiency of pullulan

increased with increasing inhibitor concentrations and decreased with increase in temperature. Pullulan

acted as a mixed inhibitor, underwent chemical adsorption and obeyed Freundlich adsorption isotherm.

Pullulan – a biodegradable polymer emerged as a potential, cost effective environmentally benign inhibitor

for the corrosion control of 6061-aluminum in HCl medium.

Key words: 6061-Al alloy; hydrochloric acid; adsorption isotherm; SEM-EDX

41

ICET

ullulan as an ecofriendly green inhibitor for corrosion

ICET

ullulan as an ecofriendly green inhibitor for corrosion control of 6061-al alloy

ICETcontrol of 6061-al alloyCharitha B.P and P

ICETCharitha B.P and P


ICETDepartment of Chemistry, Manipal Institute of T

ICET, Manipal Institute of T*E mail: [email protected]

ICET*E mail: [email protected]

inhibition

ICET

inhibition characteristics

ICET

characteristics

c

ICET

co

ICET

on

ICET

nt

ICET

tr

ICET

ro

ICET

ol

ICET

l o

ICET

of

ICET

f 6

ICET

60

ICET

06

ICET

61

ICET

1 a

ICET

al

ICET

l

potentiodynamic ICET

potentiodynamic polarization ICET

polarization

Effect ICET

Effect of ICET

of inhibitor ICET

inhibitor ICET

thermodynamic ICET

thermodynamic

CHydroxylamine

CHydroxylamine

ullulan as an ecofriendly green inhibitor for corrosion Cullulan as an ecofriendly green inhibitor for corrosion control of 6061-al alloyCcontrol of 6061-al alloy

Sforefront

Sforefront

literature

Sliterature till

Still

Hydroxylamine SHydroxylamine hydrochloride; Shydrochloride; -201

7diverse

-201

7diverse 3,4-disubstituted

-201

73,4-disubstituted

hydroxylamine

-201

7hydroxylamine hydrochloride

-201

7hydrochloride

products

-201

7products in

-201

7in aqueous

-201

7aqueous medium

-201

7medium

cyclo-addition

-201

7cyclo-addition reaction

-201

7reaction was

-201

7was performed

-201

7performed

water

-201

7water which

-201

7which is

-201

7is having

-201

7having unique

-201

7unique

medium

-201

7medium fulfilling

-201

7fulfilling the

-201

7the earnest

-201

7earnest

their

-201

7their derivatives

-201

7derivatives possesses

-201

7possesses

of -201

7of all -2

017

all heterocyclic -201

7heterocyclic

till -201

7till date.-2

017

date.

3, -201

7

3,

OP-31

Synthesis, characterization and study of new thiazole -2-amine derivative as corrosion inhibitors for mild steel

in 0.5 M H2SO4 solution

1 1*Manjunath Hegde and S. P. Nayak

1Department of Chemistry, S.D.M. College, Honavar, Karnataka 581334, India1*Department of Chemistry, Mangalore University, Mangalagangotri, Karnataka 574199, India

*Corresponding author: E-mail: [email protected], Mob: 9448724552

The derivatives of thiazole-2-amine, namely N-[(E)-(5-bromo-2-methoxyphenyl)methylidene]-4-phenyl-1,3-

thiazol-2-amine (H-THS) and N-[(E)-(5-bromo-2-methoxyphenyl)methylidene]-4-(4-bromophenyl)-1,3-

thiazol-2-amine (Br-THS) were synthesized and were applied as corrosion inhibitors. These compounds

have been characterized by IR, H NMR, C NMR & LCMS spectra. The effect of thiazole compounds on the

dissolution of Mild steel in 0.5M H2SO4 solution was studied using weight loss and Tafel plot techniques. It

was found that the inhibition efficiency of these compounds increased with increasing concentration. The

effect of temperature on corrosion behavior was investigated and also some thermodynamic parameters

(Ea, ∆Ho and ∆So) were calculated. The results indicated that inhibition efficiencies were enhanced with an

increase in concentration of inhibitor and decreased with rise in temperature. The probable inhibitory

mechanism was further supported by results obtained from polarization (Tafel plots) studies. The adsorption

obeys Langmuir adsorption isotherm. The kinetic and thermodynamic parameters were calculated.

Scanning electron microscopy (SEM) was performed for the surface study of the uninhibited and inhibited

mild steel samples.

Keywords: Corrosion inhibitor; spectroscopic studies; adsorption; mild steel.

OP-32

Studies on Isolation and Biochemical Characterization of Collagen from Skin of Arabian Sea fish Sardinella longiceps

1 2 1Niveditha N.B , Sarojini B.K * and Avinash Kudva1Biochemistry Division, Department of Chemistry, Mangalore University,

Mangalagangotri 574199, Karnataka, India. [email protected]; [email protected]

2*Department of Industrial Chemistry, Mangalore University, Mangalagangotri- 574199,

Karnataka, India. [email protected]

Fish protein is an essential source of nutrient for many people, especially in developing countries. Fish

processing industry produces more than 60% by-products as waste, which include head, skin, trimmings, fins,

frames, viscera, roes, and only 40% fish products are used for human consumption. Large quantities of fish by-

product waste from fisheries create serious pollution and disposal problems in both developed and

developing countries. These wastes contain good amount of protein rich materials that are normally

processed into low market-value products. Research has been carried out in order to develop methods to

convert these wastes into value added products. The proteins in fish can be divided into three groups of which

collagen (30% of the total protein content of animal body) forms a major component of the connective tissue.

There is a little information available regarding collagen and its hydrolysates isolated from Indian oil sardine

(Sardinella longiceps). So, the present study is aimed at extraction and isolation of collagen from its skin and

characterization using SDS-PAGE, FTIR and SEM. The isolated acid soluble collagen protein content was

42

ICET

spectroscopic

ICET

spectroscopic

Studies on Isolation and Biochemical Characterization of Collagen

ICETStudies on Isolation and Biochemical Characterization of Collagen

from Skin of Arabian Sea fish Sardinella longiceps

ICETfrom Skin of Arabian Sea fish Sardinella longiceps

Niveditha N.B

ICET

Niveditha N.B

Biochemistry Division, Department of Chemistry

ICET

Biochemistry Division, Department of ChemistryMangalagangotri 574199, Karnataka, India.

ICET

Mangalagangotri 574199, Karnataka, India. [email protected]; [email protected]

ICET

[email protected]; [email protected] of Industrial Chemistry IC

ETDepartment of Industrial Chemistry

an ICET

an

Cperformed

Cperformed

spectroscopic Cspectroscopic studies; Cstudies; adsorption; Cadsorption; S

obtained

Sobtained from

Sfrom polarization

Spolarization

kinetic

Skinetic and

Sand thermodynamic

Sthermodynamic

performed Sperformed for Sfor the Sthe surface Ssurface -2

017

N-[(E)-(5-bromo-2-methoxyphenyl)methylidene]-4-phenyl-1,3-

-201

7N-[(E)-(5-bromo-2-methoxyphenyl)methylidene]-4-phenyl-1,3-

4

-201

74-

-201

7-(

-201

7(4

-201

74-

-201

7-b

-201

7br

-201

7ro

-201

7om

-201

7mo

-201

7op

-201

7p

inhibitors.

-201

7inhibitors. These

-201

7These compounds

-201

7compounds

effect

-201

7effect of

-201

7of thiazole

-201

7thiazole compounds

-201

7compounds

weight

-201

7weight loss

-201

7loss and

-201

7and T

-201

7Tafel

-201

7afel Tafel T

-201

7Tafel T plot

-201

7plot

was found that the inhibition efficiency of these compounds increased with increasing concentration. The

-201

7was found that the inhibition efficiency of these compounds increased with increasing concentration. The

and

-201

7and also

-201

7also some

-201

7some thermodynamic

-201

7thermodynamic

that

-201

7that inhibition

-201

7inhibition efficiencies

-201

7efficiencies

with -201

7with rise -2

017

rise in -201

7in temperature. -2

017

temperature.

polarization -201

7polarization (T-2

017

(Tafel -201

7afel (Tafel (T-201

7(Tafel (T

thermodynamic -201

7

thermodynamic

OP-33Novel schiff's bases of substituted 2-amino benzothiazoles :

design, synthesis and antimicrobial activityaa a* a aD. Sai priy , Suvarna G. Kini , Varadaraj Bhatt G , Ekta Rathi ,

b bAnuraag Muralidharan , Ananthamurthy Koteshwara .

aDepartment of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

bDepartment of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical sciences, Manipal University, Karnataka, India. E-mail : [email protected]

Substituted 2-amino benzothiazole Schiff's bases were prepared by one step process by condensing

substituted 2-amino benzothiazole with substituted benzaldehydes. Synthesized compounds were

characterized by IR spectroscopy, H1 NMR spectroscopy and Mass spectrometry data. All synthesized

compounds were screened for their in vitro antimicrobial activities using agar diffusion method against a

panel of bacterial strains such as Gram-positive bacteria S.areus, B.subtilis. Gram-negative bacteria: E-coli,

P.aeruginosa and fungal strains such as Candida albacans and Anspergillus niger. Compound S13 showed

moderate activity against S.aureus. Compound S13 had the best antifungal activity against Candida

albicans and S17 showed good activity against Aspergillus niger among the novel Schiff's base compounds

when compared to standard.

found to be 4.46 mg/g. Collagen characterization using SDS-PAGE revealed that skin collagen has type I

collagen. From the FTIR spectra, four amide groups (Amide A, Amide I, Amide II and Amide III) were identified

as major peaks. The region of amide I, amide II and amide III are known to directly related with the shape of a

polypeptide. SEM is used to examine the microstructure of the collagen of Sardinella longicepes. The regions

consists of many layers, fibrillary, and flaky in random orientation with reference to the standard acid-soluble

type I calf-skin collagen. It was found that a great amount of fish skin was dumped as waste, but the results

showed that it is possible to use the fish skin as an important collagen source. It has widespread applications in

numerous fields such as pharmaceutical, medical, biomedical, food industry, cosmetics, etc. Its application in

the pharmaceutical as well as biomedical field is due to its characteristics such as weak antigenicity, cell

attachment ability, biodegradability and biocompatibility.

43

ICET

H1

ICET

H1 NMR

ICET

NMR

their

ICET

their in

ICET

in vitro

ICET

vitro antimicrobial

ICET

antimicrobial

such

ICETsuch as

ICETas Gram-positive

ICETGram-positive bacteria

ICETbacteria

strains

ICETstrains such

ICETsuch as

ICETas Candida

ICETCandida

against

ICET

against S.aureus.

ICET

S.aureus. Compound

ICET

Compound

showed

ICET

showed good

ICET

good activity

ICET

activity

compared

ICET

compared to

ICET

to standard.

ICET

standard.

CSchiff's

CSchiff's bases

Cbases

t

Cth

Ch s

Csu

Cub

Cbs

Cst

Cti

Cit

Ctu

Cut

Cte

Ced

Cd

NMR CNMR spectroscopy Cspectroscopy

antimicrobial Cantimicrobial

bacteria Cbacteria

S, Manipal, Karnataka, India.

S, Manipal, Karnataka, India.

Department of Pharmaceutical Biotechnology

SDepartment of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical sciences,

S, Manipal College of Pharmaceutical sciences,

, Karnataka, India. E

S, Karnataka, India. E-mail : [email protected]

S-mail : [email protected]

were Swere prepared Sprepared

bSbeSenSnzSz

-201

7Novel schiff's bases of substituted 2-amino benzothiazoles :

-201

7Novel schiff's bases of substituted 2-amino benzothiazoles : design, synthesis and antimicrobial activity

-201

7design, synthesis and antimicrobial activity

a

-201

7aaradaraj Bhatt G

-201

7aradaraj Bhatt G , Ekta Rathi

-201

7, Ekta Rathi

, Ananthamurthy K

-201

7, Ananthamurthy Koteshwara

-201

7oteshwara

, Manipal College of Pharmaceutical Sciences,

-201

7, Manipal College of Pharmaceutical Sciences,

, Manipal, Karnataka, India.-201

7, Manipal, Karnataka, India.

, Manipal College of Pharmaceutical sciences, -201

7, Manipal College of Pharmaceutical sciences,

-mail : [email protected]

7

-mail : [email protected]

weak

-201

7weak antigenicity

-201

7antigenicity

OP-34

Polyphenol functionalized halloysite nanotube incorporated polysulfone hollow fiber membranes for efficient dye removal

a bG P Syed Ibrahim Arun M Isloora* and A.F.Ismail

aMembrane technology Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore-575 025, India

bAdvanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia

Abstract: Superficial functionalization of the hollow fiber membrane with progressive nanomaterials exhibits

high hydrophilicity, outstanding selectivity, and permeability. In the present study, a simple and novel loose

nanofiltration (NF) membranes were prepared by the addition of tannic acid functionalized halloysite

nanotubes (THNTs) in polysulfone (PSf) membrane matrix via phase inversion method. The successful

modification of halloysite (HNTs) was confirmed by FT-IR, zeta potential measurement, TGA, TEM and

EDX analysis. The membrane permeation studies were carried with a sequence of salts (NaCl and Na2SO4)

and dyes (reactive black 5 and reactive orange 16). The resulted membranes exhibited increased

hydrophilicity, porosity, water uptake, antifouling performance, along with higher dye rejection (> 99 % for

reactive black 5 and > 95 % of reactive orange 16) and low salt rejection (7.5 % of NaCl and 2.5 % of Na2SO4)

properties. The nanocomposite membrane also exhibited the highest pure water flux of 92 L/ m2 h

compared to the pristine membrane of 18 L/ m2 h made it worthy candidate for the wastewater purification.

Keywords: loose nanofiltration; salt and dye removal; halloysite nanotube; tannic acid; hollow fiber

membrane

44

OP-35Preparation of fluorescent carbon dots from agro waste

Ajithkumar M P, Sabu Thomas*, Nandakumar Kalarikkal

International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala-686560, India

*Corresponding Author: Sabu Thomas, E-mail: [email protected]

Abstract: Nitrogen containing carbon dots with fluorescence were synthesized from agro waste materials

by a feasible microwave treatment. The as-prepared CQDs possess abundant surface functional groups,

excellent photostability and bio-compatibility. The CQDs were characterized by UV-Visible spectroscopy,

Raman spectroscopy, transmission electron microscopy, dynamic light scattering, X-ray photoelectron

spectroscopy and photoluminescence spectroscopy. The average size obtained was 8.3nm. The

photoluminescence studies showed that the CQD exhibits blue fluorescence.

ICET

Preparation of fluorescent carbon dots from agro waste

ICET

Preparation of fluorescent carbon dots from agro waste

Ajithkumar M P

ICETAjithkumar M P, Sabu Thomas*, Nandakumar Kalarikkal

ICET, Sabu Thomas*, Nandakumar Kalarikkal Ajithkumar M P, Sabu Thomas*, Nandakumar Kalarikkal Ajithkumar M P

ICETAjithkumar M P, Sabu Thomas*, Nandakumar Kalarikkal Ajithkumar M P

International and Inter University Centre for Nanoscience and Nanotechnology

ICETInternational and Inter University Centre for Nanoscience and Nanotechnology

Mahatma Gandhi University

ICET

Mahatma Gandhi University*Corresponding Author: Sabu Thomas, E-mail: [email protected]

ICET

*Corresponding Author: Sabu Thomas, E-mail: [email protected]

Nitrogen

ICET

Nitrogen containing

ICET

containing carbon

ICET

carbon

feasible

ICET

feasible

ICET

microwave

ICET

microwave treatment.

ICET

treatment.

excellent ICET

excellent photostability ICET

photostability and ICET

and

spectroscopy ICET

spectroscopy

a ICET

an ICET

nd ICET

d

Cdye

Cdye removal;

Cremoval;

Preparation of fluorescent carbon dots from agro waste CPreparation of fluorescent carbon dots from agro waste

Sexhibited

Sexhibited

made

Smade it

Sit worthy

Sworthy

removal; Sremoval; halloysite Shalloysite -2

017

nanomaterials

-201

7nanomaterials

a

-201

7a simple

-201

7simple and

-201

7and

acid

-201

7acid functionalized

-201

7functionalized halloysite

-201

7halloysite

inversion

-201

7inversion method.

-201

7method. The

-201

7The

-IR, zeta potential measurement, TGA

-201

7-IR, zeta potential measurement, TGA

a

-201

7a sequence

-201

7sequence of

-201

7of salts

-201

7salts (NaCl

-201

7(NaCl

resulted

-201

7resulted membranes

-201

7membranes

performance,

-201

7performance, along

-201

7along with

-201

7with higher

-201

7higher

salt

-201

7salt rejection

-201

7rejection (7.5

-201

7(7.5 %

-201

7%

exhibited -201

7exhibited the -2

017

the highest -201

7highest -2

017

candidate -201

7

candidate

Fabrication and properties of dye sensitized solar cell from dye extract from Callindra Haematocephala as sensitizer

Prathima Mathias D.A*., Ganesha Achary, Sahana B.S. and Latha M.V.

Department of PG studies in Chemistry, I.D.S.G. Government College, Chickmagalur 02, Karnataka, India.

[email protected]

The ZnO2 nanostructured electrodes were prepared using standard hydrothermal method on FTO coated

glass as the substrate. These coated plates were used as working electrodes. Dye Sensitized Solar Cells

(DSSC) was prepared incorporating natural dye extract from Calliandra Haematocephala dye and iodide

solution as electrolyte. The natural dye from flowers of Calliandra Haematocephala was extracted using

solutions of pH varying from 1 to 10 using distilled water, hydrochloric acid and sodium hydroxide.

Absorption maxima of all the extracts were detected using UV- Visible spectrophotometer. The crystallinity

of prepared electrode was determined using X-ray diffraction technique. The effect of natural dye extract on

the efficiency of the solar cell was studied by varying two main parameters like pH of the dye solution and

time. The efficiency of dye solution with acidic pH was very high in comparison to basic solutions. The solar

cells prepared were stable over a period of seven days and gave similar results. Only I micro liter

concentration of the dye solution was sufficient to bring about effective energy conversion. With the help of

the PV plots, FF, maximum power values were determined. The controls showed no power output.

Key words: Calliandra Haematocephala, ZnO2, hydrothermal, X-ray diffraction, pH, time.

Synthesis, characterization and biological activity of 4-aminoantipyrine incorporated azo dye

1 1 2C.T. Keerthi kumar , J.Keshavayya ,* and Sameer R patil1Department of Studies and Research in Chemistry, School of Chemical Sciences,Kuvempu University, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India,

2Department of Biochemistry, Kuvempu University, Jnana Sahyadri,Shankaraghatta-577451, Karnataka, India.

e-mail:[email protected]

A series of heterocyclic azo dyes were synthesized by diazotization of 4-Aminoantipyrine in concentrated

hydrochloric medium, followed by coupling with different coupling components such as 6-hydroxy-4-

methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile, 6-hydroxy-1,4-dimethyl-2-oxo-1,2-dihydropyridine-3-

carbonitrile and 1-ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydro pyridine-3-carbonitrile. Coupling

components were synthesized by single step reaction and the structure of these compounds was confirmed

by spectral characterization. Synthesized heterocyclic azo dyes were characterized by UV-Vis, IR, 1H-NMR,

elemental analysis and Mass spectral techniques. The synthesized heterocyclic azo dyes were screened for

biological activity. The results of these investigations revealed that the newly synthesized compounds are

potent antimicrobial agents.

Keywords: 4-Aminoantipyrine, azo dyes and biological activity.

PP-01

PP-02

45

ICET

Haematocephala,

ICET

Haematocephala, ZnO2,

ICET

ZnO2,

Synthesis, characterization and biological activity of

ICETSynthesis, characterization and biological activity of


ICET


ICET

C.T

ICET

C.T. K

ICET

. KC.T. KC.T

ICET

C.T. KC.T eerthi kumar

ICET

eerthi kumar

Department of Studies and Research in Chemistry

ICET

Department of Studies and Research in ChemistryK

ICET

Kuvempu University

ICET

uvempu University2

ICET

2

Jnana Sahyadri,Shankaraghatta-577451, Karnataka, India. ICET

Jnana Sahyadri,Shankaraghatta-577451, Karnataka, India.

heterocyclic IC

ET

heterocyclic

Csufficient

Csufficient to

Cto bring

Cbring

were

Cwere determined.

Cdetermined.

Haematocephala, CHaematocephala, ZnO2, CZnO2, hydrothermal, Chydrothermal, S

two

Stwo

was

Swas very

Svery high

Shigh

seven Sseven days Sdays and Sand

bring Sbring about Sabout effective Seffective

determined. Sdetermined. The SThe

-201

7hydrothermal

-201

7hydrothermal method

-201

7method on

-201

7on F

-201

7FTO

-201

7TO

electrodes.

-201

7electrodes. Dye

-201

7Dye Sensitized

-201

7Sensitized Solar

-201

7Solar

Haematocephala

-201

7Haematocephala dye

-201

7dye

Haematocephala

-201

7Haematocephala was

-201

7was

hydrochloric

-201

7hydrochloric acid

-201

7acid and

-201

7and

Visible

-201

7Visible spectrophotometer

-201

7spectrophotometer

diffraction

-201

7diffraction technique.

-201

7technique. The

-201

7The effect

-201

7effect

main -201

7main parameters -2

017

parameters

high -201

7high in -2

017

in comparison -201

7comparison

gave -201

7

gave

Synthesis and characterization of azo dyes derived from |2-amino-4-arylthiazole

Vinod Kumar and J. Keshavayya*

.*Department of PG Studies and Research in Chemistry, School of Chemical Sciences,Kuvempu University, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India

Present work describes the synthesis of title compound and its azo dyes with the help of various coupling

agents have been reported. Diazotization of 4-(4-methylphenyl) thiazol-2-amine was carried out with nitrosyl

sulphuric acid at 0 - 5℃ in acidic media. Further, this diazonium salt is coupled with different coupling agents

in acidic medium. The synthesized dyes were characterized by various analytical techniques like FT-IR, 1H

NMR and LCMS. The UV-Visible studies and salvatochromic behavior of all dyes in different solvents with

polarity were examined and a meaningful correlation was observed. The synthesized dyes were screened

for antibacterial activity by agar diffusion method.

Key words: Azo dye; 4-(4-methylphenyl) thiazol-2-amine; Diazotization; N, N-Dimethylaniline

PP-03

New cyanopyridne light emitting polymers for pled applications1 1 2Naveenchandra Pilicode , Madhukar.A , A.Vasudeva Adhikari

1, 2 Department of Chemistry, National Institute of Technology Karnatak-575025Corresponding author: A. Vasudeva Adhikari, [email protected]

In the present work, we aim to synthesize new donor-acceptor (D-A) type cyanopyridine based conjugated

polymers possessing good light emitting properties for opto-electronic applications. Herein, we report the

synthesis of two new conjugated polymers consisting of biphenylene and thiophene as donors and

cyanopyridine as acceptor via multi-step synthesis. These new polymers were characterized by FTIR, NMR

and GPC techniques followed by elemental analysis. Their linear optical properties were studied using UV-

visible and photo-luminescence spectroscopy in solution and film state. Linear optical results reveal that

these polymers have very good light emitting properties with optical band gap of 2.9 and 3.2 whereas their

electrochemical studies using cyclic voltammetry show the band gap of 2.8 and 3.1. Further, their TGA

results reveal that the newly synthesized polymers are quite stable till 350�C. The experimental results

indicate that these polymers are promising candidates for PLED applications.

Keywords: Cyanopyridne; donor-acceptor; light emitting polymer.

PP-04

46

ICETemitting

ICETemitting

conjugated

ICET

conjugated polymers

ICET

polymers

via

ICETvia multi-step

ICETmulti-step synthesis.

ICETsynthesis.

followed

ICETfollowed by

ICETby elemental

ICETelemental analysis.

ICETanalysis.

photo-luminescence

ICETphoto-luminescence spectroscopy

ICETspectroscopy

have

ICET

have very

ICET

very good

ICET

good light

ICET

light emitting

ICET

emitting

electrochemical

ICET

electrochemical studies

ICET

studies using

ICET

using cyclic

ICET

cyclic

reveal

ICET

reveal that

ICET

that the

ICET

the newly

ICET

newly synthesized

ICET

synthesized

indicate

ICET

indicate that

ICET

that these

ICET

these

ICET

polymers

ICET

polymers

eywords: ICET

eywords: Cyanopyridne; ICET

Cyanopyridne;

C, National Institute of T

C, National Institute of T

Corresponding author: A

CCorresponding author: A. V

C. Vasudeva Adhikari, [email protected]

Casudeva Adhikari, [email protected]. Vasudeva Adhikari, [email protected]. V

C. Vasudeva Adhikari, [email protected]. V

synthesize

Csynthesize new

Cnew donor

Cdonor-acceptor

C-acceptor

emitting Cemitting properties Cproperties for Cfor opto-electronic Copto-electronic

polymers Cpolymers consisting Cconsisting

synthesis. Csynthesis.

SNew cyanopyridne light emitting polymers for pled applications

SNew cyanopyridne light emitting polymers for pled applications

, Madhukar

S, Madhukar.A

S.A, Madhukar.A, Madhukar

S, Madhukar.A, Madhukar

, National Institute of TS, National Institute of Technology KarnatakSechnology Karnatak, National Institute of Technology Karnatak, National Institute of TS, National Institute of Technology Karnatak, National Institute of Tasudeva Adhikari, [email protected] Adhikari, [email protected]

-acceptor S-acceptor

-201

7different

-201

7different coupling

-201

7coupling

techniques

-201

7techniques like

-201

7like

dyes

-201

7dyes in

-201

7in different

-201

7different solvents

-201

7solvents

synthesized

-201

7synthesized dyes

-201

7dyes were

-201

7were

Diazotization;

-201

7Diazotization; N,

-201

7N, N-Dimethylaniline

-201

7N-Dimethylaniline

New cyanopyridne light emitting polymers for pled applications-201

7New cyanopyridne light emitting polymers for pled applications

1 -201

71.A -2

017

.A , A-201

7, A.V-2

017

.Vasudeva Adhikari-201

7asudeva Adhikari.Vasudeva Adhikari.V-201

7.Vasudeva Adhikari.V

echnology Karnatak-201

7

echnology Karnatak

Microwave assisted synthesis and characterization of pH responsive Banana pseudo-stem-g-poly (sodium acrylate-co-acrylamide)

superabsorbent hydrogel1 1* 2 3

Kabiru Bello , Balladka Kunhana Sarojini , Badiadka Narayana and Anjali Rao1Department of Studies in Industrial Chemistry. Mangalore University,

Mangalagangothri – 574 199, Karnataka State, India.2Department of Studies in Chemistry. Mangalore University,

Mangalagangothri – 574 199, Karnataka State, India.MSc course in Biochemistry,

Mangalore University, Mangalagangothri-574 199, Karnataka State, IndiaE-mail: [email protected],*[email protected]

In this work, an environmentally benign superabsorbent hydrogel based on banana pseudo-stem waste

material has been synthesized. Initially, microcrystalline cellulose was extracted from freshly prepared

banana pseudo-stem by alkaline hydrolysis with sodium hydroxide for removal of lignin and hemicelluloses

followed by bleaching process using sodium chlorite. The hydrogel was prepared by free radical graft co-

polymerization of sodium acrylate and acrylamide on to banana pseudo-stem cellulose (BPS) backbone

using ammonium persulfate (APS) and N,N-methylene-bis-acrylamide (MBA) as free radical initiator and

cross linking agent respectively. In the optimization process, effect of various factors (initiator, monomer and

crosslinker concentrations) selected at various levels on graft yield and graft efficiency were investigated

and the optimum condition for initiator, monomers and cross linker concentrations were found to be

0.0032mol/L, 0.013mol/L and 0.00048mol/L respectively. Structural confirmation of the hydrogel prepared

was performed by FT-IR spectroscopy whereas the morphology and thermal properties assessments were

performed by SEM and TGA analysis respectively. The optimized hydrogel was evaluated for its swelling

behavior under different contact time and pH solutions. The time at which the hydrogel exhibited maximum

swelling was used to assess the pH sensitivity of the hydrogels in solutions with different pH (2, 4, 7, 9&12).

The maximum swelling was found to be 323 g/g in pH7 solution for a contact time of 570min. These results

indicated that the hydrogel is amphoteric in nature.

Keywords: Banana pseudo-stem; Hydrogel; Microwave

Straightforward synthesis of calcium levulinate from biomass-derived levulinic acid and calcium carbonate in egg-shells

Sharath B. O. and Saikat Dutta*

National Institute of Technology Karnataka (NITK), Surathkal, Mangalore-575025E-Mail address of Corresponding Author: [email protected]

4-Oxopentanoic acid or levulinic acid (LA) has been recognized by NREL, USA for its huge commercial

potentials and listed as one of the top-ten biomass-derived, renewable chemical. LA has been used as a

renewable chemical building block in producing fuels and fuel additives, solvents, polymers, home care

products, agrochemicals, and pharmaceuticals. Calcium levulinate (CaLe) is a well-studied nutritional

supplement for calcium. CaLe has also been recognized as a novel chemical intermediate in synthesizing

levulinic biofuels. The reported syntheses of CaLe almost exclusively involve reaction between LA and

calcium hydroxide in an aqueous medium. An excess of calcium hydroxide is generally used to ensure that

PP-05

PP-06

47

ICET

spectroscopy

ICET

spectroscopy whereas

ICET

whereas

analysis

ICET

analysis respectively

ICET

respectively

contact

ICETcontact time

ICETtime and

ICETand pH

ICETpH solutions.

ICETsolutions.

assess

ICETassess the

ICETthe pH

ICETpH sensitivity

ICETsensitivity of

ICETof

was

ICETwas found

ICETfound to

ICETto be

ICETbe 323

ICET323 g/g

ICETg/g

hydrogel

ICET

hydrogel is

ICET

is amphoteric

ICET

amphoteric in

ICET

in

Banana

ICET

Banana pseudo-stem;

ICET

pseudo-stem;

ICET

Hydrogel;

ICET

Hydrogel;

Straightforward synthesis of calcium levulinate from biomass-derived ICET

Straightforward synthesis of calcium levulinate from biomass-derived levulinic acid and calcium carbonate in egg-shells IC

ETlevulinic acid and calcium carbonate in egg-shells

Cmonomers

Cmonomers

0.00048mol/L

C0.00048mol/L respectively

Crespectively

whereas

Cwhereas the

Cthe morphology

Cmorphology

respectivelyCrespectively. C. The CThe

solutions. Csolutions.

Sprocess,

Sprocess,

levels

Slevels on

Son graft

Sgraft

monomers Smonomers and Sand cross Scross

respectivelySrespectively. S. Structural SStructural

morphology Smorphology

-201

7, Mangalagangothri-574 199, Karnataka State, India

-201

7, Mangalagangothri-574 199, Karnataka State, India

E-mail: [email protected],*[email protected]

-201

7E-mail: [email protected],*[email protected]

on

-201

7on banana

-201

7banana pseudo-stem

-201

7pseudo-stem

was

-201

7was extracted

-201

7extracted from

-201

7from freshly

-201

7freshly

for

-201

7for removal

-201

7removal of

-201

7of lignin

-201

7lignin and

-201

7and

hydrogel

-201

7hydrogel was

-201

7was prepared

-201

7prepared by

-201

7by

banana

-201

7banana pseudo-stem

-201

7pseudo-stem cellulose

-201

7cellulose

N,N-methylene-bis-acrylamide

-201

7N,N-methylene-bis-acrylamide (MBA)

-201

7(MBA)

effect -201

7effect of -2

017

of various -201

7various

yield -201

7

yield and -201

7

and

completion of reaction. The unreacted Ca(OH)2 is precipitated as CaCO3 by passing CO2 into the clear

solution. Finally, the CaCO3 is filtered and the filtrate is evaporated to obtain crystalline CaLe.1 Whereas the

purity of calcium source is important for nutritional uses, it is of lesser importance in case of fuels production.

The egg-shells in the poultry industry have only niche markets and mostly goes to waste and used for land-

fills. Interestingly, the egg-shells of birds contain nearly 95% CaCO3 that could be used for synthesizing

CaLe for biofuels production. Interestingly, synthesis of CaLe by direct reaction between CaCO3 and LA is

virtually absent in the literature. Hereby, we report the results of the production of CaLe from biomass-derived

LA and CaCO3. In order to ensure the completion of reaction, CaCO3 was used in excess. The unreacted

CaCO3 was conveniently separated by filtration. In principle, the released CO2 gas can be recycled in

making fresh CaCO3. Our results show that more than 95% isolated yields of CaLe (calculated based on the

amount of LA used) can be obtained reproducibly by simply heating a mixture of LA and powdered CaCO3 in

aqueous medium under mechanical stirring. The purity of the product was checked by melting point, FTIR,

and 1H-NMR spectroscopy.

Keywords: Levulinic acid; Calcium levulinate; Renewable Chemistry.

Phytochemical screening and antimicrobial, antioxidant activity of leaves extract of Canthium dicoccum

1 *1 1 1Meghashree K.S , Latha K.P , Vagdevi H. M and Jayanna N.D .1Department Chemistry Sahyadri Science College (Autonomous),

Shimoga, Karnataka, India*[email protected]

The current study was designed to detect phytoconstituent and to evaluate the antimicrobial and antioxidant

activity of Canthium dicoccum leaves. Phytochemical screening has been conducted using conventional

protocol. The pet-ether, ethylacetate and methanolic leaves extracts of Canthium dicoccum have been

further taken for antimicrobial activity againt bacterial strain such as Escherichia coli (ATTC-8739),

Staphylococcus aureus (ATTC-6538), (ATTC-9027), Vibro cholerae (ATTC-6633), Bacillus cereus (ATTC-

11778), Staphylococcus epidermidis (ATTC-12228) and Salmonella typhimurium (ATTC-23564),

Aspergillus niger and Candida albicans. The ethyl acetate extract showed potent zone of inhibition against

S. typhi with standard drug Ciprofloxacin and methanol extract displays significant free radical scavenging

activity. The antimicrobial activity of leaves extract of Canthium dicoccum may be due to the presence of

phytochemical constituents.

Keywords: Canthium dicoccum, antimicrobial activity, antioxidant activity and Ciprofloxacin

PP-07

48

ICET

detect

ICET

detect phytoconstituent

ICET

phytoconstituent

leaves.

ICET

leaves. Phytochemical

ICET

Phytochemical

ethylacetate

ICETethylacetate and

ICETand methanolic

ICETmethanolic

antimicrobial

ICETantimicrobial activity

ICETactivity againt

ICETagaint

aureus

ICETaureus (A

ICET(AT

ICETT(AT(A

ICET(AT(A T

ICETTC

ICETC-6538),

ICET-6538), (A

ICET(AT

ICETT(AT(A

ICET(AT(A

o

ICET

oc

ICET

co

ICET

oc

ICET

cc

ICET

cu

ICET

us

ICET

s e

ICET

ep

ICET

pi

ICET

id

ICET

de

ICET

er

ICETrm

ICET

m

ICET

i

ICET

id

ICET

di

ICET

i

niger

ICET

niger and

ICET

and Candida

ICET

Candida albicans.

ICET

albicans.

with

ICET

with standard

ICET

standard drug

ICET

drug Ciprofloxacin

ICET

Ciprofloxacin

The ICET

The antimicrobial ICET

antimicrobial activity ICET

activity

phytochemical ICET

phytochemical constituents. ICET

constituents. ICET

Canthium ICET

Canthium

CDepartment Chemistry Sahyadri Science College (Autonomous),

CDepartment Chemistry Sahyadri Science College (Autonomous),

Shimoga, Karnataka, India

CShimoga, Karnataka, India

*[email protected]

C*[email protected]

phytoconstituent Cphytoconstituent

Phytochemical CPhytochemical

methanolic Cmethanolic

Sleaves extract of Canthium dicoccum

Sleaves extract of Canthium dicoccum

*1

S*1.P

S.P , V

S, Vagdevi H. M

Sagdevi H. M, Vagdevi H. M, V

S, Vagdevi H. M, V

Department Chemistry Sahyadri Science College (Autonomous), SDepartment Chemistry Sahyadri Science College (Autonomous), Shimoga, Karnataka, IndiaSShimoga, Karnataka, India

*[email protected]*[email protected]

-201

7gas

-201

7gas can

-201

7can

(calculated

-201

7(calculated

LA

-201

7LA and

-201

7and powdered

-201

7powdered CaCO3

-201

7CaCO3

checked

-201

7checked by

-201

7by melting

-201

7melting point,

-201

7point,

Chemistry

-201

7Chemistry.

-201

7.

Phytochemical screening and antimicrobial, antioxidant activity of

-201

7Phytochemical screening and antimicrobial, antioxidant activity of

leaves extract of Canthium dicoccum-201

7leaves extract of Canthium dicoccum

1-201

71agdevi H. M-201

7

agdevi H. M and Jayanna N.D-201

7

and Jayanna N.D

Synthesis, characterization, antimicrobial, antioxidant and cytotoxicity studies of some benzoxazoles derivatives

1 1* 1Anees Fathima , H.M. Vagdevi , and N.D.Jayanna1 Department of Chemistry, Sahyadri Science College, Shimoga-577203, India.

*Corresponding author: [email protected]

Novel different benzoxazoles derivatives namely2-[1-(1,3-benzoxazol-2-ylmethyl)-5-methyl-1H-1,2,3-triazol-

4-yl]-1,3-benzoxazole were designed, synthesized and further structurally characterized by IR, 1H NMR, 13C

NMR, Mass and elemental analysis. The synthesized compounds 6(a-h) were screened for their

antimicrobial, antioxidant and cytotoxicity studies. The biological screening results revealed that 6b, 6c, 6d

and 6f were potent against standard bacterial strains and promising anticancer agents against PBMC cell

lines with exhibited substantial cytotoxic activity in the range of 58-78%.

Keywords: Benzoxazoles, MTT assay, DPPH, Orthoaminophenols, PBMCs.

PP-08

PP-09Synthesis and biological evaluation of carbazole and

phenylacetamide hybrids1 2 1*Shivarudrappa H. P , Praveen Satapute and K. M. Hosamani

1Department of Studies in Chemistry, Karnatak University, Dharwad-580003, India.2 Department of Microbiology and Biotechnology, Karnatak University, Dharwad, Karnataka, India

In the present study, 9H-carbazole was utilized as a precursor to prepare series of carbazole and

phenylacetamide hybrids and screened for their biological activity. All the newly synthesized compounds

are characterized by elemental analyses and spectroscopic techniques. The titled compounds (1a-1i) are

evaluated for their in-vitro anti-inflammatory activity by using protein denaturation bioassay and antibacterial

studies. The title compound (1a) has shown most potent anti-inflammatory activity amongst all the

compounds. The other compounds (1b), (1d) and (1f) have shown moderate activity.

Keywords: Carbazole, Anti-inflammatory and Antibacterial Activity.

PP-10Diabetic activity of holarrhena antidysenterica leaves in

alloxan-induced diabetic rats

Latha K.P and Sweetha C

Department of Chemistry, P.G. Studies and Research in Chemistry, Sahyadri Science College (Autonomous), Shimoga-577201, Karnataka, (India)

In olden days medicinal plants have been used in traditional medicines for their antidiabetic properties

without any scientific support and pharmacological evidence. The present study was undertaken to evaluate

the antihyperglycemic activity of the crude extracts of leaves of Holarrhena antidysenterica.

Antihyperglycemic activity have been screened by using pet ether, chloroform and ethanolic extracts in

glucose-hyperglycaemic and alloxan-induced diabetic rats. Glucometer is used to measure blood glucose

level,. Glibenclamide was used as a reference drug at a dose of 0.6 mg/kg. The antioxidant activity of the test

samples was studied in the liver tissue of diabetic rats by measuring catalase and lipid peroxidation levels.

The results showed that ethanolic extract possessed a significant antihyperglycaemic and antioxidant

activity equipotent with the reference drug (glibenclamide), when evaluated in diabetic rats.

Keywords: Holarrhena antidysenterica; Antidiabetic; Antioxidant; Glibenclamide, Alloxan-diabetic rats

49

ICET


ICET


anti-inflammatory

ICET

anti-inflammatory

ICET

activity

ICET

activity

(1a)

ICET(1a) has

ICEThas shown

ICETshown

compounds

ICETcompounds (1b),

ICET(1b), (1d)

ICET(1d) and

ICETand

Carbazole,

ICETCarbazole, Anti-inflammatory

ICETAnti-inflammatory and

ICETand

Diabetic activity of holarrhena antidysenterica leaves in

ICET

Diabetic activity of holarrhena antidysenterica leaves in

ICET

Department of Chemistry ICET

Department of ChemistrySahyadri Science College (Autonomous), Shimoga-577201, Karnataka, (India) IC

ETSahyadri Science College (Autonomous), Shimoga-577201, Karnataka, (India)

Cutilized

Cutilized

for

Cfor their

Ctheir biological

Cbiological

are characterized by elemental analyses and spectroscopic techniques. The titled compounds (1a-1i) are Care characterized by elemental analyses and spectroscopic techniques. The titled compounds (1a-1i) are

activity Cactivity by Cby using Cusing

shown Cshown most Cmost

S, Praveen Satapute

S, Praveen Satapute

, Karnatak University

S, Karnatak University

Department of Microbiology and Biotechnology

S Department of Microbiology and Biotechnology, Karnatak University

S, Karnatak University

as Sas a Sa precursor Sprecursor

biological Sbiological activitySactivity

are characterized by elemental analyses and spectroscopic techniques. The titled compounds (1a-1i) are S


-201

7s

-201

7sc

-201

7cr

-201

7re

-201

7e

revealed

-201

7revealed that

-201

7that

anticancer

-201

7anticancer agents

-201

7agents against

-201

7against PBMC

-201

7PBMC

PBMCs.

-201

7PBMCs.

Synthesis and biological evaluation of carbazole and

-201

7Synthesis and biological evaluation of carbazole and

phenylacetamide hybrids

-201

7phenylacetamide hybrids

2 -201

72, Praveen Satapute -2

017

, Praveen Satapute and K-201

7 and K. M. Hosamani-2

017

. M. Hosamani

, Karnatak University-201

7, Karnatak University, Dharwad-580003, India.-2

017

, Dharwad-580003, India., Karnatak University-2

017

, Karnatak University

Green synthesis of �-bromochalcones and 1, 2, 4 –triazolo [3, 4, - b] thiadiazines derived from them for cytotoxic activity

a aHarshitha K. R. and B. K. Sarojini *

aDepartment of Industrial Chemistry, Mangalore University, Mangalagangothri 574 199, Mangaluru, Karnataka, India

*[email protected]

Compounds with chalcone as a backbone have been reported to possess various pharmacological and

biological activities. Selective bromination of the double bond of chalcones leads to �-bromochalcone

derivatives. These compounds are useful synthetic intermediates in pharmaceutical synthesis and have

become important precursors for the development of certain biologically active compounds such as

thiazoles, pyrazoles, triazolothiadiazines, imidazoles etc. But bromination using conventional method

requires the use of toxic elemental bromine which has many disadvantages. Hence an efficient, convenient

method was planned to synthesize �-bromochalcones using N-bromosuccinamide in the presence of

montmorillonite clay as a ecofriendly catalyst; in its presence N-bromosuccinamide undergoes protonation

and bromocation can be generated. A 1, 2, 4 –triazolo [3, 4, - b] thiadiazine derivatives have found

importance in pharmaceutical field. The reaction between 4-amino-3-mercapto1, 2, 4-triazoles and �-

bromochalcones conveniently yield 1, 2, 4–triazolo [3, 4, - b] thiadiazines in an one step reaction. Hence a

series of triazolothiadiazine derivatives are synthesized by the condensation of 1, 2, 4 triazoles with �-

bromochalcones and subjected for cytotoxic activity. Some of these fused heterocycles showed promising

results.

pH Sensitive behavior of composite hydrogels of chitosan and alginate: characterization and its use in encapsulation of citral

1 2 2Masrat Maswal , Saima afzal and Aijaz Ahmad Dar

1Department of Chemistry, Govt. Degree College Pulwama2 Department of Chemistry, University of Kashmir.

Hydrogels of pure chitosan and composite hydrogels formed by complexation of chitosan and sodium

alginate at various pH values were synthesized and characterized by rheology and spectroscopy. Chitosan

shows gelation at neutral and basic pH while sodium alginate remains in solution form at all pH values. In

composite hydrogels the chain associations between the two constituent polymers have different levels of

connectivity and junction zones depending upon their mixing weight fraction ratio and pH of the synthetic

medium. An array of hydrogels with variation in structural dynamics, viscoelasticity and thus mechanical

strength, and encapsulation capacity was obtained. At acidic pH, a higher weight fraction of alginate

increased the elasticity of the hydrogels while at basic pH more percentage of chitosan stabilized the

hydrogel. The interaction between chitosan and alginate is maximum at acidic pH so strongest composite

hydrogels were obtained at acidic pH and gel strength decreased on increasing the pH of the synthetic

medium. The synthesized hydrogels were studied for their encapsulation capability towards citral, chitosan

hydrogels showed maximum solubilization capacity followed by the composite hydrogels prepared at

neutral pH. The study investigates the interaction between chitosan and alginate polymers at various pH

levels for better understanding of niche of its applicability in research and industry.

PP-11

PP-12

50

ICETpH Sensitive behavior of composite hydrogels of chitosan and

ICETpH Sensitive behavior of composite hydrogels of chitosan and

alginate: characterization and its use in encapsulation of citral

ICETalginate: characterization and its use in encapsulation of citral

1

ICET1

Masrat Maswal

ICET

Masrat Maswal , Saima afzal

ICET

, Saima afzal1

ICET

1Department of Chemistry

ICET

Department of Chemistry2

ICET

2Department of Chemistry

ICET


Hydrogels

ICET

Hydrogels of

ICET

of pure

ICET

pure chitosan

ICET

chitosan and

ICET

and

at ICET

at various ICET

various pH ICET

pH values ICET

values ICET

shows gelation at neutral and basic pH while sodium alginate remains in solution form at all pH values. In ICET

shows gelation at neutral and basic pH while sodium alginate remains in solution form at all pH values. In

hydrogels ICET

hydrogels

Ccytotoxic

Ccytotoxic activity

Cactivity

pH Sensitive behavior of composite hydrogels of chitosan and CpH Sensitive behavior of composite hydrogels of chitosan and

Sbetween

Sbetween

[3,

S[3, 4,

S4, -

S- b]

Sb]

synthesized

Ssynthesized by

Sby the

Sthe

activity Sactivity. S. Some SSome of Sof these Sthese -2

017

pharmacological

-201

7pharmacological

leads

-201

7leads to

-201

7to �-bromochalcone

-201

7�-bromochalcone

pharmaceutical

-201

7pharmaceutical synthesis

-201

7synthesis

active

-201

7active compounds

-201

7compounds

bromination

-201

7bromination using

-201

7using conventional

-201

7conventional

disadvantages.

-201

7disadvantages. Hence

-201

7Hence an

-201

7an efficient,

-201

7efficient,

N-bromosuccinamide

-201

7N-bromosuccinamide

N-bromosuccinamide

-201

7N-bromosuccinamide

[3,

-201

7[3, 4,

-201

74, -

-201

7- b]

-201

7b] thiadiazine

-201

7thiadiazine

between -201

7between 4-amino-3-mercapto1, -2

017

4-amino-3-mercapto1,

thiadiazines -201

7thiadiazines -2

017

condensation -201

7

condensation

[(Phenyl)-iminomethyl] naphthalene derivatives as novel bioactive ligands: Antibacterial activity and insilico docking

a a,b,c cR. Devika Bhai , C.R Girija and R. Ramakrishna Reddya Research & Development Centre, Bharathiar University, Coimbatore, India

b SSMRV Degree college, Jayanagar 4th T block, Bangalore, Indiac Government Science College, Nrupathunga Road, Bangalore, India

[email protected]*

Antibacterial activities and insilco molecular docking proficiency of five Schiff base analogues were

investigated and their SAR was studied. Antibacterial activities against gram-negative and gram-positive

bacteria were evaluated by using well diffusion method and the molecule L3(c); 1-[(E)-(4-

hydroxyphenyl)iminomethyl]naphthalene-2-ol was observed as the most efficient out of all the tested

samples. The antibacterial activities of L3(c) was compared with an earlier research work and concluded that

the anti bacterial activities of these Schiff base analogues can be improved by introducing OH groups in their

core structure. Docking interactions against p55blk kinase protein were investigated and the compound

L3(a);1-[(E)-(3-nitrophenyl)iminomethyl] naphthalene-2-ol exhibited good docking proficiency with 24

interactions based on statistical potential. The compound L3(d); (E)-1-(2-methoxy-1-naphthyl)-N-(3-nitro

phenyl)methanimine showed significant docking interaction based on hydrogen bonding.

Keywords: Schiff Base, antibacterial properties, Docking Studies, Knowledge-based interactions.

PP-13

High performance supercapacitor from electrochemically deposited pt-pani nanomaterials

1 1 1 1Sudhakar Y N , Anitha Varghese , Akshaya K B and Louis George1Department of Chemistry, Christ University, Bengaluru


Electrochemically deposited porous film of poly(aniline) (PANI) on stainless steel (SS) current collector is

used as the substrate for electrochemical deposition of Platinum (Pt). PANI facilitates the formation of Pt

nanoflowers with an enhanced electrochemical active surface area, when compared with sub-micron size Pt

particles deposited on bare SS electrode. Owing to enhanced surface area of Pt nanoflowers, the Pt-

PANI/SS electrode shows greater electrochemical performance than Pt/SS electrode towards

supercapacitor application. SEM image of PANI shows highly porous surface and Pt-PANI shows uniform

nanoflower like deposition. Cyclic voltametery studies shows redox peaks in PANI and on deposition of Pt

enhanced specific capacitance was observed with double layer characteristics in supercapacitor. The

fabricated supercapacitor showed specific conductance of 857 Fg-1 with good cyclic stability during

charge-discharge studies.

Keywords: poly(aniline)-platinum-nanomaterial-supercapacitor

PP-14

51

ICET

pt-pani nanomaterials

ICET

pt-pani nanomaterials

, Anitha V

ICET

, Anitha Varghese

ICET

arghese, Anitha Varghese, Anitha V

ICET

, Anitha Varghese, Anitha V


ICETDepartment of Chemistry


ICETE-mail: [email protected]

deposited

ICET

deposited porous

ICET

porous film

ICET

film

substrate

ICET

substrate for

ICET

for electrochemical

ICET

electrochemical

with

ICET

with an

ICET

an enhanced

ICET

enhanced electrochemical

ICET

electrochemical

deposited

ICET

deposited on

ICET

on bare

ICET

bare S

ICET

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S e ICET

el ICET

le ICET

ec ICET

ct ICET

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od ICET

de ICET

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supercapacitor ICET

supercapacitor application. ICET

application. ICET

deposition. ICET

deposition.

CHigh performance supercapacitor from electrochemically deposited

CHigh performance supercapacitor from electrochemically deposited

pt-pani nanomaterialsCpt-pani nanomaterials1C1argheseCarghese , Akshaya K BC, Akshaya K B

Department of ChemistryC


Sinteraction

Sinteraction

Docking

SDocking Studies,

SStudies,

High performance supercapacitor from electrochemically deposited SHigh performance supercapacitor from electrochemically deposited pt-pani nanomaterials

Spt-pani nanomaterials

-201

7gram-negative

-201

7gram-negative and

-201

7and

e

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7ec

-201

7cu

-201

7ul

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7le

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7e L

-201

7L3

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73(

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7(c

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7c)

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efficient

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7efficient out

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7all the

-201

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research

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improved

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7improved by

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7by introducing

-201

7introducing OH

-201

7OH

protein

-201

7protein were

-201

7were investigated

-201

7investigated

exhibited

-201

7exhibited good

-201

7good docking

-201

7docking

L3(d);

-201

7L3(d); (E)-1-(2-methoxy

-201

7(E)-1-(2-methoxy

interaction -201

7interaction based -2

017

based on -201

7on hydrogen -2

017

hydrogen

Studies, -201

7Studies, Knowledge-based -2

017

Knowledge-based

Metal complexes of (N-(3-methoxyphenyl)-2-[(2E)-3-phenylprop-2-enoyl] hydrazinecarboxamide: Spectral, thermal, molecular docking

and biological studies

1 1 2 1 1Yuvaraj T.C.M , P. Parameshwara Naik , T.V.Venkatesh , T.Manjuraj ,Vittal Rao K. S

1Department of Chemistry, Sahyadri Science College (Auto), Shimoga, Karnataka (INDIA).2Department of Chemistry, Kuvempu University, Shankaraghatta, Karnataka (INDIA).

A series of metal complexes of Co(II), Ni(II), Cu(II), Zn(II) and Mn(II) with (N-(3-methoxyphenyl)-2-[(2E)-3-

phenylprop-2-enoyl]hydrazinecarboxamide (CMI) have been synthesized and successfully characterized

using various physicochemical and spectral techniques such as UV-Visible, IR, 1H-NMR, and LC-Mass, and

thermal stability of the metal complexes as been performed. These studies showed that the ligands

coordinate to the metal atom in a monobasic bidentate manner and octahedral environment around the

metal atoms has been proposed to the complexes. The synthesized compounds were evaluated for in vitro

antioxidant DPPH assay, in which Co(II) and Cu(II) metal complexes showed excellent activity and it is allied

with molecular docking analysis by using human antioxidant enzyme DTT (PDB:3MNG). The ligand CMI and

their metal complexes were screened for their antifungal and antibacterial activities against different species

of pathogenic fungi and bacteria and their biopotency has been performed.

Keywords: Semicarbazones, metal complexes, TGA, antioxidant, Molecular docking.

PP-15

PP-16Synthesis, characterization and total antioxidant capacity of

some new imidazopyridine chalcone derivatives1 1

Sharanya Kuthyala and G. K Nagaraja1Department of Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India.


Chalcone is well known for its diverse nature as a therapeutic agent and an interesting synthon for synthetic

chemist in the field of drug discovery. In our present study, some new imidazopyrdine-chalcones have been

synthesized and have been well characterized particularly by IR, 1HNMR, 13CNMR and MS-MS analysis.

The method followed for the title compounds is via synthesis of 1-(3,7/6-dimethylimidazo[1,2-a]pyridine-2-

yl)ethan-1-one and then by base catalyzed Claisen-Schimdt condensation reaction1. The yield obtained for

the method adapted is 78%. The synthesized compounds have also been evaluated for their total

antioxidant capacity. The study was based on the reduction of Mo(VI) to Mo(V) by the sample analyte and the

subsequent formation of a green phosphate/Mo(V) complex at acidic pH2.

Keywords: Imidazopyridine-chalcone; Claisen-Schimdt condensation reaction; total antioxidant capacity.

52

ICET

Synthesis, characterization and total antioxidant capacity of

ICET

Synthesis, characterization and total antioxidant capacity of some new imidazopyridine chalcone derivatives

ICET

some new imidazopyridine chalcone derivatives

Sharanya K

ICETSharanya Kuthyala

ICETuthyala


ICETDepartment of Chemistry, Mangalore University

ICET, Mangalore University

E

ICETE-mail: [email protected], [email protected]

ICET-mail: [email protected], [email protected]

known

ICET

known for

ICET

for its

ICET

its diverse

ICET

diverse nature

ICET

nature

the

ICET

the field

ICET

field of

ICET

of drug

ICET

drug discovery

ICET

discovery

synthesized

ICET

synthesized and

ICET

and have

ICET

have been

ICET

been well

ICET

well

method ICET

method followed ICET

followed for ICET

for the ICET

the

yl)ethan-1-one ICET

yl)ethan-1-one and ICET

and ICET

then ICET

then

adapted ICET

adapted

CSynthesis, characterization and total antioxidant capacity of CSynthesis, characterization and total antioxidant capacity of some new imidazopyridine chalcone derivativesCsome new imidazopyridine chalcone derivatives

uthyalaC

uthyala

Shas

Shas been

Sbeen

TGA

STGA,

S, antioxidant,

Santioxidant, -2

017

(N-(3-methoxyphenyl)-2-[(2E)-3-

-201

7(N-(3-methoxyphenyl)-2-[(2E)-3-

successfully

-201

7successfully characterized

-201

7characterized

1H-NMR,

-201

71H-NMR, and

-201

7and LC

-201

7LC-Mass,

-201

7-Mass,

studies

-201

7studies showed

-201

7showed that

-201

7that the

-201

7the

octahedral

-201

7octahedral environment

-201

7environment

compounds

-201

7compounds were

-201

7were evaluated

-201

7evaluated

complexes

-201

7complexes showed

-201

7showed excellent

-201

7excellent

enzyme

-201

7enzyme DT

-201

7DTT

-201

7T (PDB:3MNG).

-201

7(PDB:3MNG).

and

-201

7and antibacterial

-201

7antibacterial activities

-201

7activities

been -201

7been performed.-2

017

performed.

antioxidant, -201

7

antioxidant, Molecular -201

7

Molecular

Design and synthesis of receptor for neurotransmitter dopamine

1 2 3Arunangshu Kundu , Rinki Brahma , and Sushobhan Ghosh

Dept. of Chemistry, Gauhati University, Guwahati, Assam, 781014, [email protected] ; [email protected];

[email protected]

Neurotransmitter is an endogenous molecule transmitting electrical impulse from a nerve cell to another

nerve, muscle, organ, or other tissues to play roles as messengers of neurologic information. Dopamine is a

neurotransmitter that belongs to the class of biogenic amines. Malfunctioning of dopamine-responsive

neurons may lead to diseases such as Parkinsonism,Schizophrenia, hypertension and

pheochromocytoma. Dopamine receptors play an important role in cellular signaling processes in the

nervous system. Meanwhile, considerable efforts have been made for the development of artificial

dopamine receptors in order to unravel dopamine binding mechanisms at the molecular level in biological

systems [1]. Most of these artificial receptors provide a single binding site either for ammonium ion or the

catechol hydroxyl groups of dopamine and is limited in organic solvents only. The recognition of dopamine

in water or at biological pH is difficult. In this report we have synthesized Pd-based complexes with the new

ligand L and Pd(tmeda)(NO3)2 in 1:1 ration as shown in scheme1. Reaction of pyromellitic acid sodium salt

with Pd(tmeda)(NO3)2 in 0.5 : 1 ration resulted in the synthesis of another Pd-complex P as shown in

scheme 1. The 1H-NMR spectral studies for Pd-complex shows the possibility for the formation of both

square (S) and triangular (T) supramolecular Pd-complex. The binding reactions of Pd-based complexes

with dopamine show clear binding via hydrogen bonding between oxygen atoms (of imides group of Pd-

complex) and amine group of dopamine.

Keywords: Neurotransmetters; Artificial Dopamine receptors.

Synthesis of (4-bromo-3-fluorophenyl)(pyrimidin-5-yl)methanol and their transition metal complexes; Spectral, XRD, cytotoxicity,

molecular Docking and biological evaluation1 1* 2

Mohammed Shafeeulla R , Ganganaik Krishnamurthy, Halehatti S. Bhojynaik ,1 1Yuvaraj TCM , and Manjuraj T

1* Department of Chemistry, Sahyadri Science College (Auto), Shimoga, Karnataka (INDIA).2Department of Industrial Chemistry, Janna Sahyadri, Kuvempu University, Shankaraghattha,

Corresponding author: Dr. G. KrishnamurthyE-mail: [email protected], Tel: +91 9448774649

The article deals with a study of a new series of transition metal complexes like Co(II), Ni(II), Cu(II) and Zn(II)

with Pyrimidine based ligand derivative (4-bromo-3-fluorophenyl)(pyrimidin-5-yl)methanol (PYM) has

been synthesized via Barbier type reaction and structurally characterized by 1H NMR, IR, UV–visible and

powder XRD spectral techniques. The powder XRD studies reveals that all complexes are in crystalline

nature. The cytotoxic activity of the complexes and the uncoordinated ligand against human breast cancer

(MCF-7) and chronic myelogenous leukemia cell line (K-562) exhibits good viability in the range of

52.11–66.23% at a concentration of >100-110µg/mL as compared to the inhibition in the untreated cells.

Finally the antibacterial activity revealed that the cobalt(II) and copper(II) metal complex is active against the

studied bacteria and fungi and the cytotoxicity studies are correlated with computational docking analysis.

Keywords: Barbier reaction, lithium metal, sonochemistry

PP-17

PP-18

53

ICET

dopamine.

ICET

dopamine.

ICET

Artificial

ICET

Artificial Dopamine

ICET

Dopamine

Synthesis of (4-bromo-3-fluorophenyl)(pyrimidin-5-yl)methanol and

ICETSynthesis of (4-bromo-3-fluorophenyl)(pyrimidin-5-yl)methanol and

their transition metal complexes; Spectral, XRD

ICET

their transition metal complexes; Spectral, XRDmolecular Docking and biological evaluation

ICET

molecular Docking and biological evaluation

Mohammed Shafeeulla R

ICET

Mohammed Shafeeulla R



Department of Industrial Chemistry ICET

Department of Industrial Chemistry

Csupramolecular

Csupramolecular Pd-complex.

CPd-complex.

hydrogen

Chydrogen bonding

Cbonding

dopamine. Cdopamine.

Dopamine CDopamine receptors.Creceptors.

Sthe

Sthe synthesis

Ssynthesis

Pd-complex

SPd-complex shows

Sshows

Pd-complex. SPd-complex. The SThe binding Sbinding

bonding Sbonding between Sbetween

-201

7dopamine-responsive

-201

7dopamine-responsive

a

-201

7a,

-201

7, h

-201

7hy

-201

7yp

-201

7pe

-201

7er

-201

7rt

-201

7te

-201

7e

signaling

-201

7signaling processes

-201

7processes

for

-201

7for the

-201

7the development

-201

7development

mechanisms

-201

7mechanisms at

-201

7at the

-201

7the molecular

-201

7molecular level

-201

7level

systems [1]. Most of these artificial receptors provide a single binding site either for ammonium ion or the

-201

7systems [1]. Most of these artificial receptors provide a single binding site either for ammonium ion or the

solvents

-201

7solvents only

-201

7only.

-201

7. The

-201

7The recognition

-201

7recognition

synthesized

-201

7synthesized Pd-based

-201

7Pd-based

scheme1. -201

7scheme1. Reaction -2

017

Reaction of -201

7of

synthesis -201

7synthesis of -2

017

of another -201

7another

shows -201

7

shows the -201

7

the

PP-19Synthesis, thermal and mechanical studies of chitosan-acetaldehyde

schiff base

Vishwanath T

Department of Materials Science, Mangalore University, Mangalagangothri-574199Email- [email protected]

The development of new applications of chitosan is due to the fact that it is a natural, biodegradable and non-

toxic polymer.1 Schiff bases have been drawing attention in the literature, especially after the use of chitosan

to form articles such as, membranes and fibres2. The reported chitosan Schiff base derivatives have shown

less stability than the pristine chitosan2. In this study acetaldehyde was taken to modify the amine functional

group of chitosan and its thermal and mechanical properties were studied. The sample was characterized

by FT-IR spectroscopy and elemental analysis. The SEM images indicated that the surface was porous and

had inclusions. The degradation temperature of Schiff base was lower than chitosan by 25 oC and

percentage weight loss was reduced for Schiff base by 4% than chitosan. The tensile strength of the Schiff

base film was 21 MPa and that of chitosan film was 25 MPa. It was concluded that the acetaldehyde Schiff

base film showed less deviation in thermal and mechanical properties than chitosan as compared to

chitosan-aromatic aldehyde Schiff bases reported in literature2.

Keywords: Chitosan, acetaldehyde, Schiff base.

Thermo gravimetric study of some bisazo complexes

1 2 3Anitha, Fasiulla, Chidananda B1,3 Department of Chemistry, Sahyadri Science College, Shimoga, Karnataka

2 Department of Chemistry, MIT, Manipal

Abstract: This paper describes the synthesis and thermo gravimetric study of six bisazo dyes and their

metal (II) complexes. Bisazo dyes were prepared by the diazotization of m-nitroaniline followed by coupling

with aniline, p-chloro aniline, p-toluidine, p-aminobenzoic acid and p-aminophenol. CO(II), Cu(II), Mn(II),

Ni(II) and Zn(II) complexes of these bisazo dyes were prepared and their thermo dynamic activation

parameters were evaluated.

PP-20

PP-21Study of chitosan grafted silk fibre reinforced PVA films for potential

biomedical applicationsSareen Sheikh and G. K. Nagaraja

Department of Chemistry, Mangalore University, Mangalagangothri, Karnataka, India- [email protected], [email protected]

Grafting of silk using vinyl monomers was carried out over the centuries to enhance the properties of the fibre

to make it equally competent over synthetic fibres1,2. Though grafting of vinyl monomers improve the

properties of fibres, they however have a set of limitations due to the harmful products released by slow

degradation3. Techniques of environmental surface modification of fibres were introduced so as to retain the

properties of silk by grafting natural polysaccharides such as chitin and chitosan in the textile industry.

54

ICET

Anitha,

ICET

Anitha,


ICET Department of Chemistry, Sahyadri Science College, Shimoga, Karnataka

ICET, Sahyadri Science College, Shimoga, Karnataka2

ICET2 Department of Chemistry

ICET Department of Chemistry

describes

ICETdescribes the

ICETthe synthesis

ICETsynthesis

complexes.

ICET

complexes. Bisazo

ICET

Bisazo dyes

ICET

dyes were

ICETwere prepared

ICET

prepared

p-chloro

ICET

p-chloro aniline,

ICET

aniline, p-toluidine,

ICET

p-toluidine,

Zn(II)

ICET

Zn(II) complexes

ICET

complexes of

ICET

of these

ICET

these

parameters

ICET

parameters were

ICET

were evaluated.

ICET

evaluated.

ICET

Study of chitosan grafted silk fibre reinforced PV ICET

Study of chitosan grafted silk fibre reinforced PV

CThermo gravimetric study of some bisazo complexes

CThermo gravimetric study of some bisazo complexes

2 C2 3C 3CAnitha, CAnitha, F CFasiulla,Casiulla,

, Sahyadri Science College, Shimoga, KarnatakaC, Sahyadri Science College, Shimoga, Karnataka

SThermo gravimetric study of some bisazo complexesSThermo gravimetric study of some bisazo complexes

-201

7derivatives

-201

7derivatives

modify

-201

7modify the

-201

7the amine

-201

7amine

The

-201

7The sample

-201

7sample was

-201

7was characterized

-201

7characterized

that

-201

7that the

-201

7the surface

-201

7surface was

-201

7was

lower

-201

7lower than

-201

7than chitosan

-201

7chitosan

chitosan.

-201

7chitosan. The

-201

7The tensile

-201

7tensile strength

-201

7strength

was

-201

7was concluded

-201

7concluded that

-201

7that the

-201

7the

mechanical

-201

7mechanical properties

-201

7properties than

-201

7than chitosan

-201

7chitosan

literature2.

-201

7literature2.

Anti-hypertensive guided fractionation of Nardostachys jatamansi (D. Don) D.C.

a,b a c cBeena B. R.*, Basavaraj Padmashali, Neeraj K. Patel and U. V. Babu,aDept. of Chemistry, Rani Channamma University, Belagavi, Karnataka, IndiaaDept. of Chemistry, K.L.E.'s RL Science Institute, Belagavi, Karnataka, India

cPhytochemistry Division, R and D centre, The Himalaya Drug Company, Tumkur Road, Makali, Bengaluru, Karnataka, India

[email protected]

PP-22

Acylation of fibre provides the best route to successfully graft chitosan over silk due to the enhanced surface

area it provides and thus improving its antibacterial and antifungal properties4.In the present study, the

chitosan grafted silk fibre was finely incised into minute particles and then used for preparing the films. The

films were fabricated by varying the weight ratios of grafted silk and PVA by film casting technique and further

evaluated for mechanical, morphological and cell-viability studies. The composite films demonstrated

increased mechanical properties. Moreover, grafting of chitosan onto silk was confirmed by FTIR studies.

Furthermore, biocompatibility and cellular behavior such as adhesion, proliferation, spreading and

interaction of �broblast cells were improved using the composite films when compared with the pristine

samples. Fabrication of such biodegradable and biocompatible films with enhanced bio-physical properties

may possibly be a potential material for use in tissue engineering applications.

Keywords: Grafting; silk fibre; chitosan; mechanical properties.

Nardostachys jatamansi belongs to Valerian family and grows in the Himalayas. It is a rich source aromatic

amber-colored essential oil which used in medicines and also as perfume. In Ayurveda, “Jatamansi” is

recommended for the treatment of hypertension. It is believed that this herb also has a deeply calming effect

on mind and body and is good for reducing psychological stress. The aim of the present work is to

investigate Nardostachys jatamansi (D. Don) D.C. for anti-hypertensive activity. Dried rhizomes (3 Kg) were

subjected to sequential soxhlation with dichloromethane (DCM), ethyl acetate (EtOAc), methanol (MeOH)

and water (H2O) respectively based on polarity index to yield respective extracts. Evaluation of extracts was

performed using Angiotensin Converting Enzyme (ACE) inhibition assay. Among the tested extracts, activity

was found to be prominent in EtOAc extract (93.23 % at 100 �g/mL) while captopril (standard drug) exhibited

85 % inhibition at 25nM. Subsequently, EtOAc extract (10.2 g) was subjected to silica gel column

chromatography using gradient of Hexane and EtOAc and finally with MeOH to get 8 fractions. All fractions

were submitted for ACE inhibition activity. Identification of the most potent anti-hypertensive constituent(s)

will be the subject of discussion in the present submission.

Key words: Nardostachys jatamansi; jatamansi; anti-hypertensive; fractionation; rhizomes

55

ICET

used

ICET

used

of

ICET

of hypertension.

ICEThypertension.

good

ICETgood for

ICETfor reducing

ICETreducing psychological

ICETpsychological

jatamansi

ICETjatamansi (D

ICET(D.

ICET. Don)

ICETDon) D

ICETD.C.

ICET.C.

sequential

ICETsequential soxhlation

ICETsoxhlation with

ICETwith dichloromethane

ICETdichloromethane

respectively

ICET

respectively based

ICET

based on

ICET

on polarity

ICET

polarity

using

ICET

using Angiotensin

ICET

Angiotensin Converting

ICET

Converting

to

ICET

to be

ICET

be prominent

ICET

prominent in

ICET

in EtOAc

ICET

EtOAc

inhibition

ICET

inhibition at

ICET

at 25nM.

ICET

25nM. Subsequently

ICET

Subsequently

chromatography ICET

chromatography using ICET

using gradient ICET

gradient

submitted ICET

submitted for ICET

for ACE ICET

ACE

subject ICET

subject of ICET

of

Cumkur Road, Makali, Bengaluru, Karnataka, India

Cumkur Road, Makali, Bengaluru, Karnataka, India

[email protected]

[email protected]

alerian

Calerian family

Cfamily and

Cand

in Cin medicines Cmedicines and Cand

hypertension. Chypertension. It CIt is Cis believed Cbelieved

psychological Cpsychological

S, Rani Channamma University

S, Rani Channamma University

.'s RL Science Institute, Belagavi, Karnataka, India

S.'s RL Science Institute, Belagavi, Karnataka, India

Phytochemistry Division, R and D centre, The Himalaya Drug Company

SPhytochemistry Division, R and D centre, The Himalaya Drug Company

umkur Road, Makali, Bengaluru, Karnataka, India Sumkur Road, Makali, Bengaluru, Karnataka, India [email protected]@gmail.com

grows Sgrows

-201

7Anti-hypertensive guided fractionation of Nardostachys jatamansi

-201

7Anti-hypertensive guided fractionation of Nardostachys jatamansi

Neeraj K

-201

7Neeraj K. P

-201

7. Patel and

-201

7atel and

, Rani Channamma University -201

7, Rani Channamma University, Belagavi, Karnataka, India-2

017

, Belagavi, Karnataka, India.'s RL Science Institute, Belagavi, Karnataka, India-2

017

.'s RL Science Institute, Belagavi, Karnataka, IndiaPhytochemistry Division, R and D centre, The Himalaya Drug Company-2

017

Phytochemistry Division, R and D centre, The Himalaya Drug Companyumkur Road, Makali, Bengaluru, Karnataka, India -2

017

umkur Road, Makali, Bengaluru, Karnataka, India

bio-physical

-201

7bio-physical

Electrochemical reduction of 5-metoxy-5,6-bis(3-nitrophenyl)-4,5-dihydro-l,2,4-triazine¬3 (2H)-thione on zinc cathode

with surface morphology* 1 2Srikanta S.A. , Parameshwar Naik Patikallu , Venkatesh

1 Department of Chemistry, Assistant Professor, Sahyadri Science College, Kuvempu University, Shivamogga, Karnataka India

2 Department of Chemistry, Professor, Kuvempu University, Shankaraghatta, Karnataka India.

Particle size determination is very essential and important while working with nanomaterials. The information

on many physical properties including the size, morphology, surface texture, roughness, and chemical

composition of materials is the important area of research. Moreover, advanced manipulation of the samples

during the SEM experiments can provide key information about the morphology of the crystals at the micro

and nanometer scale, as well as insights into the different reaction pathways. Electrochemical reduction of 5-

metoxy-5,6-bis(3-nitrophenyl)-4,5-dihydro-l,2,4-triazine¬3 (2H)-thione to its amine subsequently to schiff

base derivative is of great importance in studying the conductivity and the surface morphology of cathode.

The measurement of the variation of current and electrode potential with time during the electrolysis is also

the important area of research .The particle size variation in the reduction product of nitroaromatic

compound increase the biological activity. The study of biological activity of the organic molecule before and

after electrolysis is an interesting subject in pharmaceutical industry.

Keywords: Cathode surface, electrochemical reduction, surface morphology

PP-23

Solvothermal synthesis and electrochemical behavior of nico2o4 nanorods

1 2*Meenaketan Sethi and D. Krishna Bhat

Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore-575025, India. *[email protected]

NiCo2O4 nanorod arrays were synthesized by a low-temperature solvothermal method, followed by a post-

calcination treatment. The prepared NiCo2O4 nanorods were characterized by XRD, FESEM and EDXA

techniques. The XRD patterns reveal the formation of NiCo2O4 cubic phase, and the FESEM study clearly

shows the formation of rod-like morphology. EDX spectroscopy revealed that no other elements are present

except Nickel, Cobalt, and Oxygen suggesting the high purity of the product. The prepared materials were

studied as an electrode material for supercapacitor application in 2 M KOH aqueous electrolyte. In order to

study the electrochemical behavior of the prepared material cyclic voltammetry and Galvanostatic charge-

discharge measurements were carried out in a 2-electrode system. From the cyclic voltammetry data, a high

capacitance of 226 F/g was obtained at a scan rate of 2 mVs-1. Apart from high capacitance value a high

energy density of 17.6 WhKg-1 and a high power density of 1200 WKg-1 were obtained for the prepared

nanorods.

Key words: NiCo2O4; XRD; Supercapacitor.

PP-24

56

ICET

Solvothermal synthesis and electrochemical behavior of

ICET

Solvothermal synthesis and electrochemical behavior of nico2o4 nanorods

ICETnico2o4 nanorods

Meenaketan Sethi

ICETMeenaketan Sethi


ICET

Department of ChemistrySurathkal, Mangalore-575025, India. *[email protected]

ICET

Surathkal, Mangalore-575025, India. *[email protected]

nanorod

ICET

nanorod arrays

ICET

arrays were

ICET

were synthesized

ICET

synthesized

calcination

ICET

calcination treatment.

ICET

treatment. The

ICET

The prepared

ICET

prepared

techniques. ICET

techniques. The ICET

The XRD ICET

XRD patterns ICET

patterns

formation ICET

formation of ICET

of rod-like ICET

rod-like ICET

Cobalt, ICET

Cobalt,

Cpharmaceutical

Cpharmaceutical

electrochemical

Celectrochemical reduction,

Creduction,

Solvothermal synthesis and electrochemical behavior of CSolvothermal synthesis and electrochemical behavior of nico2o4 nanorodsCnico2o4 nanorods

Svariation

Svariation

study

Sstudy of

Sof biological

Sbiological

pharmaceutical Spharmaceutical industrySindustry

reduction, Sreduction, surface Ssurface

-201

7, Shankaraghatta, Karnataka India.

-201

7, Shankaraghatta, Karnataka India.

nanomaterials.

-201

7nanomaterials. The

-201

7The

texture,

-201

7texture, roughness,

-201

7roughness, and

-201

7and

advanced

-201

7advanced manipulation

-201

7manipulation of

-201

7of the

-201

7the

morphology

-201

7morphology of

-201

7of the

-201

7the crystals

-201

7crystals

pathways.

-201

7pathways. Electrochemical

-201

7Electrochemical

(2H)-thione

-201

7(2H)-thione to

-201

7to its

-201

7its amine

-201

7amine subsequently

-201

7subsequently

conductivity

-201

7conductivity and

-201

7and the

-201

7the surface

-201

7surface

potential

-201

7potential with

-201

7with time

-201

7time during

-201

7during

variation -201

7variation in -2

017

in the -201

7the reduction -2

017

reduction

biological -201

7biological activity -2

017

activity

industry-201

7

industry

Preparation of chelated complexes with micronutrients and characterization using chemical and instrumental methods

1 2Shyam Sundar. J , Nagarajan. S1 Department of Chemistry, Manipal Institute of Technology,

Manipal University, Manipal, 576014, Karnataka, India2 Spice and Flavour Sciences department,

CSIR-Central Food Technological Research Institute, Mysore

Micronutrients are important dietary components play a vital role in disease prevention. Micronutrients are

obtained from various sources that are intrinsic within the tissue matrix of the edible parts of plants and

animals and from the fluid components.Some nutrients are added to foods for commercial enhancement.

Micronutrients like zinc, iron, copper, boron and chlorine are some of the essential constituent of humans,

plants and animals as it helps in various metabolic processess in it. As these micronutrients cannot be taken

directly in the form of any states of matter it is converted to a chelated form and is used as a food

supplements. In the present report we have prepared the complexes of zinc with disodium salt of EDTA

using base catalysts like ammonia and trimethylamine and the complexes of iron using the chelators like

salicylic acid, L-phenylalanine, and 2, 2'- bipyridyl using methanol as solvent. All the synthesised molecules

were characterised by FTIR, 1H NMR, 13C NMR.

Keywords: Micronutrients; chelated complexes

Csp2-O bond formation via nickel-catalyzed cross-coupling reaction in water enabled by micellar catalysis

Dini Ahanthem and Warjeet S. Laitonjam*Department of Chemistry, Manipur University, Manipur, India


Ni-Catalyzed cross-couplings between (functionalized) aryl chlorides and alcohols resulting in Csp2-O

bond formation are described. The procedures further develop the nickel catalysed nucleophillic

substitution of aryl chloride with water. Despite the intolerance of water for transition metal catalysis, Nickel

reagents as reported, their formation as well as their use in an aqueous micellar environment are discussed

herein. The importance of C−O bond formation has been determined insofar as PCy3 ligand, surfactant and

Nickel catalyst are concerned. Various types of aromatic as well as aliphatic alcohols are employed to

synthesize various ethers with high yields and selectivity.

Keywords: Csp2-O bond formation, Ni-catalyzed reaction, arylalkyl ether, SDS, water.

PP-25

PP-26

57

ICET

Csp2-O bond formation via nickel-catalyzed cross-coupling reaction in

ICET

Csp2-O bond formation via nickel-catalyzed cross-coupling reaction in water enabled by micellar catalysis

ICET

water enabled by micellar catalysis

Dini Ahanthem and W

ICETDini Ahanthem and W

epartment of Chemistry

ICETepartment of Chemistry

E


ICET-mail: [email protected]

cross-couplings

ICET

cross-couplings between

ICET

between

a

ICET

ar

ICET

re

ICET

e d

ICET

de

ICET

es

ICET

sc

ICET

cr

ICET

ri

ICET

ib

ICET

be

ICET

ed

ICET

d.

ICET. T

ICET

Th

ICET

h

of

ICET

of aryl

ICET

aryl chloride

ICET

chloride with

ICET

with water

ICET

water

reagents

ICET

reagents as

ICET

as reported,

ICET

reported, their

ICET

their formation

ICET

formation

The ICET

The importance ICET

importance of ICET

of C−O ICET

C−O

catalyst ICET

catalyst ICET

are ICET

are concerned. ICET

concerned.

various ICET

various ethers ICET

ethers

CCsp2-O bond formation via nickel-catalyzed cross-coupling reaction in CCsp2-O bond formation via nickel-catalyzed cross-coupling reaction in water enabled by micellar catalysisCwater enabled by micellar catalysis

Dini Ahanthem and WCDini Ahanthem and W

SCsp2-O bond formation via nickel-catalyzed cross-coupling reaction in SCsp2-O bond formation via nickel-catalyzed cross-coupling reaction in

-201

7prevention.

-201

7prevention. Micronutrients

-201

7Micronutrients

edible

-201

7edible parts

-201

7parts of

-201

7of

for

-201

7for commercial

-201

7commercial enhancement.

-201

7enhancement.

essential

-201

7essential constituent

-201

7constituent

these

-201

7these micronutrients

-201

7micronutrients cannot

-201

7cannot

chelated

-201

7chelated form

-201

7form and

-201

7and is

-201

7is

complexes

-201

7complexes of

-201

7of zinc

-201

7zinc with

-201

7with disodium

-201

7disodium

the

-201

7the complexes

-201

7complexes of

-201

7of iron

-201

7iron

methanol

-201

7methanol as

-201

7as solvent.

-201

7solvent. All

-201

7All

Theoretical study of Ge doped Au nanoalloy clusters: a density functional study

1 2Prabhat Ranjan , and Tanmoy Chakraborty

1Department of Mechatronics Engineering, Manipal University Jaipur, E-mail: [email protected]

2Department of Chemistry, Manipal University Jaipur, Email: [email protected]

In this study, electronic and optical properties of AunGe (n=1-9) nanoalloy clusters are systematically

investigated in terms of the Density Functional Theory (DFT) with the Becke, three parameter, Lee-Yang-Parr

(B3LYP) exchange correlation functional. Conceptual DFT based global descriptors have turned to be

indispensable tools for correlating the experimental properties of compounds. In this study, physico-

chemical properties of AunGe (n=1-9) nanoalloy clusters are correlated in terms of DFT based descriptors

viz. HOMO-LUMO gap, Global Hardness (�), Global Softness (S), Electronegativity (�) and Electrophilicity

Index (�). Our computed bond length exhibits a close agreement with experimental data. The high value of

regression coefficient between global softness and HOMO-LUMO gap supports and validates our predicted

model.

Keywords: Density Functional Theory; Au-Ge; HOMO-LUMO Gap; Hardness

Corrosion inhibition of stainless steel using benzyl isothiocynate in acidic medium

Shwetha N, Sneha N kagatikar, and Padmalatha Rao.

Department of Chemistry, Manipal University, Manipal, Karnataka, India.

The work emphasizes the use of Benzyl isocynate as corrosion inhibitor for the corrosion control of stainless

steel in HCl medium. The study has been carried out using electrochemical techniques such as

potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) studies in

temperature ranging from 30 to 450 C with concentration of BITC ranging from 0.005 gL-1 to 0.1 gL-1. Kinetic

and thermodynamic parameters were calculated and surface analysis was performed before and after

immersing the metal into the medium with and without inhibitor. Electrochemical studies showed that

inhibitor is acting as mixed type by bringing down both cathodic and anodic reactions under control. BITC

showed maximum efficiency of 65% for 0.1gL-1 at 450 C. kinetic and thermodynamic studies showed BITC is

undergoing chemical adsorption by following Langmuir adsorption isotherm. The adsorption was

confirmed by SEM and EDX analysis.

Key words: corrosion, inhibitor, stainless steel and hydrochloric acid

PP-27

PP-28

58

ICET

Shwetha N, Sneha N kagatikar

ICET



ICET

Department of Chemistry, Manipal University

ICET

, Manipal University

of

ICETof Benzyl

ICETBenzyl isocynate

ICETisocynate

The

ICETThe study

ICETstudy has

ICEThas been

ICETbeen

polarization

ICETpolarization (PDP)

ICET(PDP) and

ICETand

ranging

ICET

ranging from

ICET

from 30

ICET

30 to

ICET

to 450

ICET

450 C

ICET

C with

ICET

with

thermodynamic

ICET

thermodynamic parameters

ICET

parameters were

ICETwere

the

ICET

the metal

ICET

metal into

ICET

into the

ICET

the medium

ICET

medium

is

ICET

is acting

ICET

acting as

ICET

as mixed

ICET

mixed type

ICET

type

maximum ICET

maximum efficiency ICET

efficiency

c ICET

ch ICET

he ICET

em ICET

mi ICET

ic ICET

ca ICET

al ICET

l

SEM ICET

SEM and ICET

and

CCorrosion inhibition of stainless steel using benzyl isothiocynate in

CCorrosion inhibition of stainless steel using benzyl isothiocynate in

acidic medium

Cacidic medium


CShwetha N, Sneha N kagatikar

Department of Chemistry CDepartment of Chemistry, Manipal UniversityC, Manipal University

isocynate Cisocynate as Cas

SCorrosion inhibition of stainless steel using benzyl isothiocynate in SCorrosion inhibition of stainless steel using benzyl isothiocynate in acidic mediumSacidic medium

Shwetha N, Sneha N kagatikarSShwetha N, Sneha N kagatikar, and PS, and PShwetha N, Sneha N kagatikar, and PShwetha N, Sneha N kagatikarSShwetha N, Sneha N kagatikar, and PShwetha N, Sneha N kagatikar

-201

7parameter

-201

7parameter

descriptors

-201

7descriptors have

-201

7have

compounds.

-201

7compounds. In

-201

7In this

-201

7this study

-201

7study,

-201

7,

terms

-201

7terms of

-201

7of DF

-201

7DFT

-201

7T based

-201

7based descriptors

-201

7descriptors

Electronegativity

-201

7Electronegativity (�)

-201

7(�) and

-201

7and Electrophilicity

-201

7Electrophilicity

with

-201

7with experimental

-201

7experimental data.

-201

7data.

gap

-201

7gap supports

-201

7supports and

-201

7and validates

-201

7validates

UMO

-201

7UMO Gap;

-201

7Gap; Hardness

-201

7Hardness

Corrosion inhibition of stainless steel using benzyl isothiocynate in -201

7

Corrosion inhibition of stainless steel using benzyl isothiocynate in

A selective and sensitive method development and validation by LC-MS/MS approach for trace level quantification of two potential

genotoxic impurities in Albendazole drug substance1, * 2 3

Nelaturi Subbaiah , Gopireddy Venkata Subba Reddy , Nitesh Kanyawar , 3 3Manish Gangrade and J Jayachandran

1 Department of Chemistry, S.R.N.B. Degree and P.G. College, Badvel, Kadapa, Andhra Pradesh, 516 227, India.

2Department of Chemistry, JNTUA College of Engineering, Pulivendula, Kadapa, Andhra Pradesh, 516 390, India.

3Cipla Ltd, Research and development, Bangalore, 560049, India. [email protected]

A simple new reverse-phase liquid chromatography coupled with mass spectrometric (LC-MS/MS) method

was developed and validated for the trace analysis of two potential genotoxic impurities, 2-nitro-4-thio

cyanato aniline (GTI-I) and 2-nitro-4-propyl thio aniline (GTI-II) in albendazole drug substance. GTI-I and GTI-

II were identified as potential genotoxic impurities through DEREK nexus software. The method utilizes

Waters X-Bridge shield RP 18 (250 mm x 4.6 mm ID, 3.5µm) column with negative ion electrospray ionization

in multiple reaction monitoring (MRM) detection mode. The isocratic program was developed. The solution-

A was 0.01M ammonium formate in water, adjusted pH 6.0 with formic acid and solution-B was acetonitrile:

methanol (50:50). The mobile phase was prepared in the ratio of 40:60 (v/v) (solution-A: solution-B). The flow

rate was 1.0 mL/min and column oven temperature was 40ºC. The method was validated as per International

Conference on Harmonization (ICH) guidelines and quantitate up to 0.5 ppm of GTI-I and GTI-II. The

correlation coefficient found for the linearity study was >0.9996 in each case. The %recovery of the added

impurities in the range of 96.0 to 104.0.

Keywords: Albendazole; LC-MS/MS; Genotoxic impurities; multiple reaction monitoring (MRM); Derek

nexus.

Synthesis and characterization of new series of thiazolidine-2,4-dione derivatives

Rakshit G. O., Ayushi Tripathi, and Santosh L. Gaonkar*

Department of Chemistry, Manipal Institute of Technology,Manipal University, Manipal, 576014, Karnataka, India

[email protected]

Thiazolidine-2,4-diones are well known for their biological activities such as antidiabetic, antibacterial,

antifungal, anti-inflammatory and antitumor activity.1 Thiazolidine-2,4-diones are part of the series of

antidiabetic drug, and they are accepted as the most effective group of drug for type 2 diabetes.

Thiazolidine-2,4-diones class drugs are also called as Glitazones, introduced in late 1990's.2 These drugs

also have the efficiency to promote adipogenisis, insulin sensitization and control the activity of

pathogenesis on cardiovascular system (CVS) complications such as atherosclerosis. A series of

Thiazolidine-2,4-dione derivatives are synthesized by the Knoevenagel condensation reaction of

Thiazolidine-2,4-dione with aromatic aldehydes followed by condensation reaction with aryl halide or alkyl

halide. Characterization of newly synthesized compounds are carried out by modern analytical techniques.

Keywords: Thiazolidine-2,4-dione, Glitazones, Knoevenagel condensation

PP-29

PP-30

59

ICET

linearity

ICET

linearity

104.0.

ICET

104.0.

LC

ICETLC

ICET-MS/MS;

ICET-MS/MS; Genotoxic

ICETGenotoxic

Synthesis and characterization of new series of

ICET

Synthesis and characterization of new series of thiazolidine-2,4-dione derivatives

ICET

thiazolidine-2,4-dione derivatives

Rakshit G. O

ICET

Rakshit G. O



Cprepared

Cprepared

Ctemperature

Ctemperature was

Cwas

guidelines

Cguidelines and

Cand

linearity Clinearity study Cstudy was Cwas >0.9996 C>0.9996

Genotoxic CGenotoxic

SThe

SThe

adjusted

Sadjusted pH

SpH 6.0

S6.0 with

Swith

prepared

Sprepared in

Sin the

Sthe ratio

Sratio

Sof

Sof 40:60

S40:60

was Swas 40ºC. S40ºC. The SThe

quantitate Squantitate

-201

7ulivendula, Kadapa,

-201

7ulivendula, Kadapa,

Cipla Ltd, Research and development, Bangalore, 560049, India.

-201

7Cipla Ltd, Research and development, Bangalore, 560049, India.

spectrometric

-201

7spectrometric (LC

-201

7(LC-MS/MS)

-201

7-MS/MS)

potential

-201

7potential genotoxic

-201

7genotoxic impurities,

-201

7impurities,

albendazole

-201

7albendazole drug

-201

7drug substance.

-201

7substance.

DEREK

-201

7DEREK nexus

-201

7nexus software.

-201

7software.

column

-201

7column with

-201

7with negative

-201

7negative

The -201

7The isocratic -2

017

isocratic program -201

7program

with -201

7with formic -2

017

formic acid -201

7acid -201

7

40:60 -201

7

40:60

Synthesis and characterisation of pyridine derivatives

Sushmithadevi, Santosh L. Gaonkar*

Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal, 576014, Karnataka, India

[email protected]

Pyridine and its derivatives are the important class of compounds with remarkable application in various

fields. Most of the pyridine derivatives exhibit significant biological applications like antituberculosis,

antimalarial, antimicrobial etc1. Some of the pyridine based drugs are anti-allergic Loratadine, anticancer

Crizotinib and anti-hypertensive Amlodipine. Pyridine ring having heterocyclic moiety readily interact with

the biomolecules and inhibit the synthesis of cell wall lipid and nucleic acid2. Pyridine moiety having 1,3,4-

oxadiazole has attracted the attention of medicinal chemists who are in search of new therapeutic

molecules. These heterocyclic moieties act as a potent ligands and form a stable complex with metals.

These metal complexes exhibit various pharmacological activities. In this paper we have synthesized some

of the pyridine derivatives derived from niazid by reaction of niazid with various substituted aldehydes.

These niazid hydrazones are converted into 1,3,4-oxadiazoles via cycloaddition using catalyst. Metal

complexes of niazid hydrazones were prepared by treating the hydrazones with metal salts. All the

synthesized molecules were characterized by spectroscopic techniques.

Keywords: Pyridine derivatives; Tuberculosis; 1,3,4-oxadiazole, metal complexes

Synthesis and evaluation of new series of 3-mercapto-1, 2, 4-triazole derivatives as antimicrobial agents

a a bSwapna B., Swarnagowri, Sushruta S. Hakkimane, b a,

Bharath Raja Guru, and Santosh L. Gaonkar *.aDepartment of Chemistry, Manipal Institute of technology (MIT), Manipal University, Manipal, India

bDepartment of Biotechnology, Manipal Institute of Technology (MIT), Manipal University, Manipal, [email protected]

The chemistry of triazoles and their derivatives received considerable attention in recent years owing to their

synthetic and biological importance. Most of the 1,2,4-triazole moieties exhibit important biological activities

such as anticonvulsant, anti-tubercular, antioxidant, antifungal, anticancer, antimicrobial1. Some of the

triazole based drugs are antibiotic Cefatrizine, anti-bacterial agent Tazobactum, anti-cancer agent CAI and

anti-HIV agent TSAO. Triazoles inhibit the lipid biosynthesis and prevent the growth of bacteria. Mercapto

substituted 1,2,4-triazole moiety has attracted the attention of chemists who are in search of new drug

molecule due to its chemopreventive and chemotherapeutic effects on cancer2. Here we report the

synthesis of new series of 3-mercapto-1,2,4-triazole derivatives derived from substituted aromatic acids and

substituted isothiocyanates. The synthesized compounds are evaluated for antimicrobial activities. Some of

the compounds demonstrated potent antimicrobial activities.

Keywords: 3-mercapto-1,2,4-Triazoles; Antimicrobial activities,

PP-31

PP-32

60

ICET

Synthesis and evaluation of new series of 3-mercapto-1, 2, 4-triazole

ICET

Synthesis and evaluation of new series of 3-mercapto-1, 2, 4-triazole derivatives as antimicrobial agents

ICET

derivatives as antimicrobial agents

a

ICETaSwapna B.,

ICETSwapna B., Swarnagowri,

ICET Swarnagowri,

Bharath Raja Guru,

ICETBharath Raja Guru,


ICET

Department of Chemistry, Manipal Institute of technology (MIT), Manipal University

ICET

, Manipal Institute of technology (MIT), Manipal UniversityDepartment of Biotechnology

ICET

Department of Biotechnology, Manipal Institute of T

ICET

, Manipal Institute of T

chemistry

ICET

chemistry of

ICET

of triazoles

ICET

triazoles and

ICET

and their

ICET

their

synthetic ICET

synthetic and ICET

and biological ICET

biological importance. ICET

importance.

anticonvulsant, ICET

anticonvulsant, ICET

drugs ICET

drugs

TSAO IC

ET

TSAO

C1,3,4-oxadiazole,

C1,3,4-oxadiazole,

Synthesis and evaluation of new series of 3-mercapto-1, 2, 4-triazole CSynthesis and evaluation of new series of 3-mercapto-1, 2, 4-triazole derivatives as antimicrobial agentsCderivatives as antimicrobial agents

Sby

Sby treating

Streating

spectroscopic

Sspectroscopic techniques.

Stechniques.

1,3,4-oxadiazole, S1,3,4-oxadiazole, metal Smetal -201

7like

-201

7like antituberculosis,

-201

7antituberculosis,

Loratadine,

-201

7Loratadine,

moiety

-201

7moiety readily

-201

7readily interact

-201

7interact

acid2.

-201

7acid2. Pyridine

-201

7Pyridine moiety

-201

7moiety having

-201

7having

are

-201

7are in

-201

7in search

-201

7search of

-201

7of new

-201

7new

and

-201

7and form

-201

7form a

-201

7a stable

-201

7stable complex

-201

7complex

activities.

-201

7activities. In

-201

7In this

-201

7this paper

-201

7paper we

-201

7we have

-201

7have

of

-201

7of niazid

-201

7niazid with

-201

7with various

-201

7various

1,3,4-oxadiazoles

-201

71,3,4-oxadiazoles via

-201

7via cycloaddition

-201

7cycloaddition

treating -201

7treating the -2

017

the hydrazones -201

7hydrazones

techniques.-201

7techniques.

metal -201

7

metal

Thermodynamic and spectroscopic studies of interaction of kanamycin with DNA

1 2Neelam Keshwani , N and Kishore1Ramniranjan Jhunjhunwala college (affiliated to Mumbai University),

Ghatkopar (W) Mumbai 400086, India2Indian Institute of Technology Bombay, Powai Mumbai 400076, India

Exploring the binding interactions of antibiotic/anticancer drugs with DNA turn out to be a dynamic field of

research at the interface between biological science and medicinal chemistry. The interaction of

aminoglycoside drug kanamycin with calf thymus DNA was studied by using spectroscopic and calorimetric

studies. In this work, we have tried to find out the binding mode of kanamycin with ctDNA under

physiological pH using spectroscopic and thermodynamic techniques. Isothermal Titration Calorimetry

(ITC) studies suggest that the binding is enthalpically favored with a small entropic change and a binding

constant of the order of 104, which remains almost same in the studied temperature range. Experiments

were done in the presence of osmolytes tetraehtylene glycol and sucrose to see the affect of altered water

activity on the binding. No appreciable change in the binding behavior as well as on the stability of the DNA-

kanamycin complex was observed, which suggests that the number of water molecule released or uptaken

is not significant in the binding process. No appreciable change in the binding affinity was observed in the

pH range of 7.0 to 9.0. Competitive fluorescence studies with DNA ethidium bromide and circular dichroism

studies show that kanamycin follows groove binding mode of interaction. Thermal denaturation studies

show that there is a 5 K stabilization of DNA at 1:10 DNA to drug molar ratio.

Keywords: kanamycin; calf thymus DNA; Isothermal titration Calorimetry; groove binding

Electrochemical studies of Aluminium- alloy using pomagranate as organic inhibitor

Ashok.s.d.*, Pruthviraj. R. D.** and Sneha Kaveramma***

*Department of chemistry,Global Adademy of Technology,Bangalore,Karnataka,India**R&D Centre,Department of Chemistry,RajaRajeswari College of

Engineering,Bangalore,Karnataka,India***Department of chemistry,Mangalore University,Mangalore,Karnataka,India

Aluminium-7075 in 1 M hydrochloric acid solution was studied by electrochemical methods. The results

show the inhibition efficiency was found to increase with increasing the concentration of the inhibitor from

100 to 300 ppm. The maximum inhibition efficiency 93.8% was observed in the presence of 300 ppm inhibitor

(in case of potentiodynamic polarization). The inhibition action of atenolol was explained in terms of

adsorption on the Aluminium-7075 surface. Electrochemical Impedance spectroscopic technique (EIS)

exhibits one capacitive loop indicating that, the corrosion reaction is controlled by charge transfer process.

Polarization measurements showed that the inhibitor is of a mixed type. The results obtained from the

different methods are in good agreement. The surface morphologies of Aluminium-7075 were examined by

scanning electron microscope (SEM).

Keywords: Corrosion; Aluminium-7075; Hydrochloric acid; Electrochemical studies;

PP-33

PP-34

61

ICET

DNA

ICET

DNA

Electrochemical studies of Aluminium- alloy using pomagranate as

ICETElectrochemical studies of Aluminium- alloy using pomagranate as

organic inhibitor

ICETorganic inhibitor

Ashok.s.d.*, Pruthviraj. R

ICET

Ashok.s.d.*, Pruthviraj. R

*Department of chemistry

ICET

*Department of chemistry**R&D Centre,Department of Chemistry

ICET

**R&D Centre,Department of Chemistry

***Department of chemistry ICET

***Department of chemistry

Aluminium-7075 ICET

Aluminium-7075 in ICET

in 1 ICET

1 M ICET

M

inhibition ICET

inhibition

Cbinding

Cbinding

at

Cat 1:10

C1:10 DNA

CDNA

DNA CDNA; C; Isothermal CIsothermal titration Ctitration Sappreciable

Sappreciable change

Schange

studies

Sstudies with

Swith DNA

SDNA

binding Sbinding mode Smode of Sof interaction. Sinteraction.

DNA SDNA to Sto drug Sdrug molar Smolar

titration Stitration

-201

7T

-201

7Th

-201

7he

-201

7e

spectroscopic

-201

7spectroscopic and

-201

7and

kanamycin

-201

7kanamycin with

-201

7with ctDNA

-201

7ctDNA

Isothermal

-201

7Isothermal T

-201

7Titration

-201

7itration Calorimetry

-201

7Calorimetry

C) studies suggest that the binding is enthalpically favored with a small entropic change and a binding

-201

7C) studies suggest that the binding is enthalpically favored with a small entropic change and a binding

studied

-201

7studied temperature

-201

7temperature range.

-201

7range.

and

-201

7and sucrose

-201

7sucrose to

-201

7to see

-201

7see the

-201

7the

behavior

-201

7behavior as

-201

7as well

-201

7well as

-201

7as on

-201

7on

the

-201

7the number

-201

7number of

-201

7of water

-201

7water molecule

-201

7molecule

change -201

7change in -2

017

in the -201

7the binding -201

7binding

DNA -201

7DNA ethidium -2

017

ethidium

interaction. -201

7

interaction.

Synthesis and characterization of 2, 5-dioxopyrrolidinyl acid amide derivatives

1 1* 2Sangeetha Karanth , Badiadka Narayana , Balladka Kunhanna Sarojini

1Department of studies in Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India2Department of Industrial Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India

1 1 2sangeethakudupu gmail.com , nbadiadka yahoo.co.uk , bksaroj35 gmail.com

A new series of substituted 2, 5-dioxopyrrolidinyl acid amides were synthesized using substituted acid 1 13hydrazides. The synthesized compounds were characterized by H-NMR, C-NMR, IR and LCMS

techniques. The crystal structures of the compounds were determined by single crystal RD. The

synthesized compounds were screened for their anti-oxidant activities using DPPH radical scavenging

assay.

Keywords: Hydrazides 2, 5- dioxopyrrolidinyl acid amides DPPH radical scavenging

PP-35

Method development and validation of aegle marmeleous

1 2 3M .Swetha , N.Saritha , and N.Devanna

1Adhoc lecturer, department of chemistry, JNTUACE Kalikiri-5172342Asst. professor, department of chemistry, JNTUACE Kalikiri-517234

3N. Devanna, professor, department of chemistry, Anthapuramu-5

Aegle marmelous is one of the important plant with several medicinal &nutraceutical properties. It is

commonly known as woody apple plant which belongs to rutaceace family. It is known for various medicinal

properties in traditional medicinal system & use to cure various diseases. The quantitation and method

development of 6-methylchromate hydrate from fruit pulp of bael using HPLC technique has not been

reported so far this contains different class of compounds of alkaloids, coumarin, terpenoids, fatty acids

and amino acids. 6-methylchromate hydrate is one of coumarin of aegle marmeleous with its potential

pharmacological activities such as hypoglycemic, anti-inflammatory, anticancer, antidiabetic, antioxidants.

The aim of the present study is to screen different parts of bael for the estimation of 6-methyl chromate

hydrate and to quantify 6-methyl chromate hydrate from bael fruit powder collected from standard

compound and its formulation using HPLC techniques. The developed method was validated as per ICH

guidelines

Keywords: 6-methylChromate hydrate by using HPLC method development, validation, biological

activities

PP-36

62

ICET

, department of chemistry

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N. Devanna, professor

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N. Devanna, professor

the

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SMethod development and validation of aegle marmeleous

SMethod development and validation of aegle marmeleous

2S2, N.Saritha S, N.Saritha , and N.DevannaS, and N.Devanna

, department of chemistryS, department of chemistry, JNTUS, JNTU

, department of chemistryS, department of chemistry

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single

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7crystal

using

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7using DPPH

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7DPPH radical

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7radical scavenging

-201

7scavenging

Hydrazides 2, 5- dioxopyrrolidinyl acid amides DPPH radical scavenging

-201

7Hydrazides 2, 5- dioxopyrrolidinyl acid amides DPPH radical scavenging

Method development and validation of aegle marmeleous-201

7Method development and validation of aegle marmeleous

Synthesis, characterization and antioxidant activity of 1,2,3 triazole carrying novel chalcones

Aminath Rajeena C.H and Suresh P.Nayak

Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka

rechunaa gmail.com

Chalcones are precursor compounds for flavonoids biosynthesis in plants, and they can also be

synthesized in laboratory. Chalcones possess a broad spectrum of biological activities including

antioxidant, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal,

anticancer, cytotoxic and immunosuppressive. Nowadays, several chalcones are used for treatment of viral

disorders, cardiovascular diseases, parasitic infections, pain, gastritis, and stomach cancer, as well as like

food additives and cosmetic formulation ingredients. In a wide search program a novel series of substituted

chalcones (3-(4-(benzyloxy)phenyl)-1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)prop-2-en-1-one) have been

synthesized by condensing 4- benzyloxy benzaldehyde with different triazole ketone derivatives in dilute

ethanolic potassium hydroxide solution at room temperature according to Claisen – Schmidt condensation.

The structures of these compounds have been investigated by Infra red spectroscopy, Nuclear magnetic

resonance spectroscopy and Mass spectrometry. The newly synthesized compounds were studied for

antioxidant activity.

Keywords: 4-benzyloxy benzaldehyde chalcones Claisen – Schmidt condensation antioxidant activity

PP-37

Synthesis of karaya gum grafted 2-(methacryloyloxyethyl)trimethyl ammonium chloride (KG-graft-METAC) for the effective removal of

anionic dyes

Preetha B. K.and Vishalakshi B.*

Department of Post-Graduate Studies & Research in Chemistry

Mangalore University, Mangalagangothri-574199 (DK), Karnataka, India.

preethagowda27 gmail.com vishalakshi2009 yahoo.com

In this study a novel Karaya Gum(KG) based hydrogel was prepared by simultaneous grafting and

crosslinking of Karaya gum with 2-(methacryloyloxy ethyl)trimethylammonium chloride (METAC) using

ammonium persulphate(APS) as initiator and N,N'-methylenebisacrylamide (MBA) as cross linker via

microwave irradiation technique. The gel was characterised using FTIR and SEM techniques. The thermal

stability of the gel was established by TGA. The hydrogel was evaluated for the removal of anionic dyes

namely Indigo Carmine (IC) and Methyl orange(MO) from aqueous solution. The adsorption kinetics of IC

was described by pseudo first order model where as that of MO was best fitted with pseudo second order

model. The equilibrium adsorption data for both dyes were well explained by Freundlich isotherm model. As

the initial dye concentration and temperature was increased, the adsorption amount of dyes also increased

and adsorption was found to be favourable.

Keywords: Karaya Gum microwave irradiation adsorption Indigo carmine Methyl orange

PP-38

63

ICETSynthesis of karaya gum grafted 2-(methacryloyloxyethyl)trimethyl

ICETSynthesis of karaya gum grafted 2-(methacryloyloxyethyl)trimethyl

ammonium chloride (KG-graft-MET

ICETammonium chloride (KG-graft-MET

Preetha B. K

ICETPreetha B. K

Department of P

ICET

Department of P

Mangalore University ICET

Mangalore University

preethagowda27 gmail.com vishalakshi2009 yahoo.com ICET

preethagowda27 gmail.com vishalakshi2009 yahoo.com

novel ICET

novel

Cchalcones

Cchalcones S

investigated

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SThe newly

Snewly

chalcones Schalcones Claisen SClaisen – S– Schmidt SSchmidt

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7they

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7and stomach

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7stomach cancer

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7cancer,

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7, as

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program

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7a novel

-201

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-201

7series

(3-(4-(benzyloxy)phenyl)-1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)prop-2-en-1-one)

-201

7(3-(4-(benzyloxy)phenyl)-1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)prop-2-en-1-one)

different

-201

7different triazole

-201

7triazole ketone

-201

7ketone

temperature

-201

7temperature according

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7according to

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7to Claisen

-201

7Claisen

investigated -201

7investigated by -2

017

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7Infra red -2

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red spectroscopy-201

7spectroscopy

newly -201

7newly synthesized -2

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synthesized

Pectin based ZnO nanocomposite hydrogel: Evaluation as adsorbent for divalent metal ions

Arun Krishna K.and Vishalakshi B.*

Department of Post-Graduate Studies & Research in Chemistry,

Mangalore University, Mangalagangothri-574199 (DK), Karnataka, India.

E-mail: akkodoth gmail.com, vishalakshi2009 yahoo.com

Synthesis of a nanocomposite hydrogel P-PAMPS-PAAm/ nO has been made by the polymerization of 2-

acrylamido-2-methyl-1-propanesulfonic acid (AMPS), acrylamide (AAm) in presence of pectin (P) and zinc

oxide ( nO) using microwave radiation. FTIR, RD, SEM and TEM studies indicated the incorporation of

nO nanoparticles within the gel network. The system was evaluated for the capacity to adsorb divalent

metal ions Cu (II) and Pb(II) from aqueous solution. The maximum capacity of the gel was found to be 76.92 -1 -1mgg for Cu(II) and 125 mgg for Pb(II). The adsorption data was found to follow Langmuir isotherm model

and second order kinetics. About 95 of the metal ions adsorbed could be stripped in a buffer solution of pH

1.2 indicating the possibility of regeneration of the gel for repeated use.

Keywords: Nanocomposite hydrogel Microwave nO nanoparticles Metal adsorption.

PP-39

Solvent-free oxidation of biomass-derived 5-(chloromethyl)furfural (CMF) into 2,5-Diformylfuran (DFF)

Ritesh Tiwari, Saikat Dutta*, and Sib Sankar Mal*

Department of Chemistry,

National Institute of Technology (NITK), Surathkal, Mangalore-575025, Karnataka, India

Corresponding Author s E-mail: sdutta nitk.edu.in, Tel.: 91-824-247400 Extn. 3219

2,5-Diformylfuran (DFF) has enormous potential as a biorenewable building block for the synthesis of

renewable polymers. 2,5-Diformylfuran (DFF) has other applications in synthesizing pharmaceuticals,

antifungal agents, and as a precursor of macrocyclic ligands. DFF has been synthesized by selective

oxidation of 5-(hydroxymethyl)furfural (HMF) using stoichiometric oxidants or under catalytic conditions. 5-

(Chloromethyl)furfural (CMF), a hydrophobic analogue of HMF, has attracted significant attention as a

biomass-derived, renewable chemical building block. CMF is a functionally equivalent alternative to HMF

that can be produced in high yield directly from sugars, carbohydrates, and even untreated biomass

feedstock. The reported method for the transformation of CMF to DFF uses DMSO as both the solvent and

oxidant. The reaction works around 150 C and requires several hours to complete. Although the yield is

good (ca. 80 ), the separation and purification of DFF from DMSO is cumbersome. Hereby, we report a

solvent-free, straightforward synthesis of DFF from CMF under mild conditions. We explored metal nitrates

as the oxidant and tried several salts. Ferric nitrate showed promising results but the yield remained low. The

best results were obtained using Bi(NO ) .5H O. The reaction can be performed by simply warming the 3 3 2

reaction mixture containing CMF and 0.7 eq. of Bi(NO ) .5H O at 40 C under mechanical stirring. The 3 3 2

reaction completes with an hour. DFF can be separated from the pasty mass by simply extracting with a

suitable organic solvent like chloroform. Bismuth salts are relatively non-toxic and environment-friendly. The

reaction parameters like temperature, equivalent of oxidant, and time of reaction were optimized for best

selectivity and yield of DFF. The best yield (60 ) of DFF was obtained by conducting the reaction at 40 C

under ultrasonic irradiation. The reaction was scaled up to gram's scale.

Keywords: Sonication, 5-(Chloromethyl) furfural, 2,5-Diformylfuran, Biomass, Bismuth Nitrate

PP-40

64

ICET


ICET


echnology (NITK), Surathkal, Mangalore-575025, Karnataka, India

ICET

echnology (NITK), Surathkal, Mangalore-575025, Karnataka, India

Corresponding Author s E

ICETCorresponding Author s E-mail: sdutta nitk.edu.in, T

ICET-mail: sdutta nitk.edu.in, T

has

ICEThas enormous

ICETenormous potential

ICETpotential

2,5-Diformylfuran

ICET2,5-Diformylfuran (DFF)

ICET(DFF)

and

ICET

and as

ICET

as a

ICET

a precursor

ICET

precursor of

ICET

of

5-(hydroxymethyl)furfural

ICET

5-(hydroxymethyl)furfural

(Chloromethyl)furfural

ICET

(Chloromethyl)furfural (CMF),

ICET

(CMF), a

ICET

a hydrophobic

ICEThydrophobic

biomass-derived,

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biomass-derived, renewable

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C(CMF) into 2,5-Diformylfuran (DFF)

C(CMF) into 2,5-Diformylfuran (DFF)

iwari, Saikat Dutta*, and Sib Sankar Mal*

Ciwari, Saikat Dutta*, and Sib Sankar Mal*

Department of ChemistryCDepartment of Chemistry

echnology (NITK), Surathkal, Mangalore-575025, Karnataka, IndiaCechnology (NITK), Surathkal, Mangalore-575025, Karnataka, India

-mail: sdutta nitk.edu.in, TC-mail: sdutta nitk.edu.in, T

SSolvent-free oxidation of biomass-derived 5-(chloromethyl)furfural

SSolvent-free oxidation of biomass-derived 5-(chloromethyl)furfural

(CMF) into 2,5-Diformylfuran (DFF)S(CMF) into 2,5-Diformylfuran (DFF)

iwari, Saikat Dutta*, and Sib Sankar Mal*Siwari, Saikat Dutta*, and Sib Sankar Mal*

-201

7AAm/ nO has been made by the polymerization of 2-

-201

7AAm/ nO has been made by the polymerization of 2-

of

-201

7of pectin

-201

7pectin

indicated

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7indicated the

-201

7the incorporation

-201

7incorporation

capacity

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7capacity to

-201

7to adsorb

-201

7adsorb

of

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7of the

-201

7the gel

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7gel was

-201

7was found

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7found

to

-201

7to follow

-201

7follow Langmuir

-201

7Langmuir isotherm

-201

7isotherm

could

-201

7could be

-201

7be stripped

-201

7stripped in

-201

7in a

-201

7a buffer

-201

7buffer

use.

-201

7use.

nanoparticles

-201

7nanoparticles Metal

-201

7Metal adsorption.

-201

7adsorption.

Solvent-free oxidation of biomass-derived 5-(chloromethyl)furfural -201

7

Solvent-free oxidation of biomass-derived 5-(chloromethyl)furfural (CMF) into 2,5-Diformylfuran (DFF)

-201

7

(CMF) into 2,5-Diformylfuran (DFF)

Synthesis, characterization, antibacterial and cytotoxic screening of 2-[(5-methoxy-1-naph thyl) thio]-1,3-benzoxazole derivatives

1 1 1N. D. Jayanna , H. M. Vagdevi *, and S.H. Shreedhara

1Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga577 203, India

vagdevihm gmail.com

A newroute have been developed in the synthesis of - (5-methoxy-1-naphthyl)thio -1,3-benzoxazole

derivatives 3a-f. The compounds 2-mercapto benzoxazoles 1 a-f were reacted with chloro derivatives of 1naphthyl compounds to yield targeted molecules. The obtained products have been characterized by IR, H

13NMR, C NMR and Mass spectral studies. The synthesized compounds have been exhibited encouraging

anticancer and antibacterial activities. The cytotoxicity assay applied to determine anticancer activity of the

compounds against Peripheral Blood Mononuclear Cells (PBMCs). The compounds were more promised

with the bacterial activity.

PP-41

1(a-f)

N

O

R

R1

R2

SH +

Cl

OCH3

ETHANOL

S

O

CH3

N

O

R

R1

R2

3(a-f)

Keywords: Benzoxazole Peripheral Blood Mononuclear Cells (PBMCs) Cytotoxic Antibacterial.

Synthesis, in vitro cytotoxic and antibacterial evaluation of 2-(1,3-benzoxazol-2-yl)-2,3-dihydrophthalazine-1,4-dione derivatives

1 1 1S. H. Shreedhara , H. M. Vagdevi *, and N. D. Jayanna

1Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577203, India

vagdevihm gmail.com

The in vitro cytotoxic activity of the selected chloro and nitro substituted benzoxazole derivatives. The

5,6,7,8-tetrabromo-2-(1,3-benzoxazol-2-yl)-2,3,5,6-tetrahydrophthalazine-1,4-dione 7(a-b), 2-(1,3-

benzoxazol-2-yl)-2,3-dihydrobenzophthalazine-1,4-dione 8a, 3-(1,3-benzoxazol-2-yl)-3,4-dihydro-1H-

1,3,4-benzotriazepine-2,5-dione 9(a-b) and7-chloro-3-(1,3-benzoxazol-2-yl)-3,4-dihydro-1H-1,3,4-

benzotriazepine-2,5-dione 10(a-b) shows more than 70 of cell viability, followed by the antibacterial and

MIC. The target derivatives were synthesized by using intermediate chloro and nitro substituted 2-1hydrazinyl-1,3-benzoxazole with different anhydrides. Obtained products have been characterized by IR, H

NMR Mass spectral studies, and evaluated their biological activity.

Keywords: Benzoxazole, Pyridazine, PBMCs, Anhydrides, Cytotoxic.

PP-42

65

ICET

Synthesis, in vitro cytotoxic and antibacterial evaluation of 2-(1,3-

ICET

Synthesis, in vitro cytotoxic and antibacterial evaluation of 2-(1,3-

ICET

benzoxazol-2-yl)-2,3-dihydrophthalazine-1,4-dione derivatives

ICET

benzoxazol-2-yl)-2,3-dihydrophthalazine-1,4-dione derivatives

S. H. Shreedhara

ICET

S. H. Shreedhara

ICET


ICET


ICET

cytotoxic ICET

cytotoxic

CBlood

CBlood Mononuclear

CMononuclear S

3(a-f)

S3(a-f)

Mononuclear SMononuclear Cells SCells

-201

7chloro

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characterized

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been

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7been exhibited

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-201

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determine

-201

7determine anticancer

-201

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compounds

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7

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73(a-f) -2

017

3(a-f)

Analgesic and hepatoprotective activity with isolation of a compound from methanol extract of seeds of kunstleria keralensis

1 1 2Kumar MD *, Sathishkumar Shetty A , and Satyanarayan ND

1Department of Pharmaceutical Chemistry, NES Academy of Research and Development,

NES Campus, Shivamogga-577201, Karnataka, India.2Department of Pharmaceutical Chemistry, Kuvempu University,P.G-centre, Kadur-577548,

Chikkamangalore district, Karnataka, India.

* kumarresearchs gmail.com

The extracts of seeds of the plant “Kunstleria keralensis” belongs to the family Fabaceae were screened for

analgesic and hepatoprotective activity. It had been also analysed for the presence of compounds by

HPTLC and GCMS. Further, it had been isolated a compound and characterized. The test samples HS

hexane extract of seeds and MS methanol extract of seeds showed significant analgesic and

hepatoprotective activity. Whereas, the test sample CS chloroform extract of seeds showed moderately

significant activity. The densitograms of methanol extract of Kunstleria keralensis at 254nm and 366nm at

both 40 and 60mm application positions have showed number of peaks. The peaks were assigned and it

revealed that peak with maximum 84 and 86 at RT -0.01 and -0.02 at 254nm. It also showed the presence of

peak with maximum 65 and 66 at RT-0.02 and -0.01. The evaluation of test sample by GCMS showed the

presence of the following probable compounds such as, Hexadecane, Heneicosane, Cholestan-5-ol-6-one,

Phenol,2,4-bis(1,1-dimethylethyl)., Phenol,2,6-bis(1,1-dimethylethyl) etc. By the above available

information's, the methanol extract of seeds was further isolated by using TLC and Column chromatography

and the spectral studies was made. It was concluded that the obtained compound is 2,4-di-tert-butylphenol.

Key words: Densitograms, Kunstleria keralensis, Solvent extraction, probable, spectra.

PP-43

Mesomorphic thermal stabilities of di chloro substituted hydrogen bonded binary mixtures

Pavitra Pai, Poornima Bhagavath*, Srinivasulu Maddasani and Apoorva M

Department of Chemistry, Manipal Institute of Technology, Manipal University

Manipal – 576 104, India, poornishashi gmail.com

A new homologous series of liquid crystals are prepared with low molar mass moieties through

intermolecular hydrogen bond interactions. A non mesogenic chloro substituted Schiff base is synthesized

and used as the proton acceptor. Mesogenic 4-n-alkyloxy benzoic acids (where n 3, 4, 5, 7, 8, 9 and 12)

are used as the proton donors. Fourier Transform Infrared Spectroscopy (FTIR) is used to characterize the

HB between the two moieties. Polarized Optical Microscope (POM) equipped with an indigenous hot stage

is used to characterize the optical textures. Differential Scanning Calorimeter (DSC) is used to determine

the phase transition temperatures and the enthalpies associated with them. The influence of chlorine

substitution on mesomorphic thermal stabilities, clearing and melting temperatures are studied in wake of

the similarly reported hydrogen bonded liquid crystals.

PP-44

66

ICET

was

ICET

was

unstleria keralensis, Solvent extraction, probable, spectra.

ICET

unstleria keralensis, Solvent extraction, probable, spectra.

ICET

Mesomorphic thermal stabilities of di chloro substituted hydrogen

ICET

Mesomorphic thermal stabilities of di chloro substituted hydrogen

P ICET

Pavitra P ICET

avitra Pai, P ICET

ai, P ICET

ICET



C,

C,2

C2,

C,6

C6

seeds

Cseeds was

Cwas further

Cfurther

was

Cwas concluded

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Cthat

unstleria keralensis, Solvent extraction, probable, spectra.Cunstleria keralensis, Solvent extraction, probable, spectra.

S-0.01.

S-0.01. The

SThe

such

Ssuch as,

Sas, Hexadecane,

SHexadecane,

b Sbi Sis Ss( S(1 S1,S,1S1-S-dSdiSimSmeSetSthSh

further Sfurther isolated Sisolated

the Sthe

-201

7abaceae

-201

7abaceae were

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7were screened

-201

7screened

presence

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7presence of

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7of compounds

-201

7compounds

characterized.

-201

7characterized. The

-201

7The test

-201

7test samples

-201

7samples

showed

-201

7showed significant

-201

7significant

chloroform

-201

7chloroform extract

-201

7extract of

-201

7of seeds

-201

7seeds showed

-201

7showed

unstleria

-201

7unstleria keralensis

-201

7keralensis at

-201

7at

both 40 and 60mm application positions have showed number of peaks. The peaks were assigned and it

-201

7both 40 and 60mm application positions have showed number of peaks. The peaks were assigned and it

and

-201

7and -0.02

-201

7-0.02 at

-201

7at 254nm.

-201

7254nm. It

-201

7It

evaluation -201

7evaluation of -2

017

of test -201

7test

Hexadecane, -201

7

Hexadecane,

Fluorescent sensor for detection of transition metal ions in water

Aiswarya Paul and Dhanya Sunil

Department of Chemistry, Manipal Institute of Technology, Manipal University, India

aishwarya.paul learner.manipal.edu

Rapid on-site, real-time monitoring of hazardous heavy metal ion analysis is a longstanding important goal

for chemical and bioprocess monitoring as well as environmental and clinical applications. This paper

reports the synthesis and characterization of a metal-binding indicator with specific optical responses on 2exposure to Cu ions. The sensor molecule was characterized using spectral techniques. The chromogenic

and fluorogenic sensing properties of chemosensor receptor towards inorganic cations were investigated. 2The chemosensor showed visual colour change exclusively towards Cu ion and also could distinguish

2 2Cu from other metal cations by different color changes in solution (DMSO:H O 4:6). The addition of Cu 2

ion quenches the fluorescence intensity of sensor molecule solution.

Keywords: Cation recognition, Chemosensor, Electrochemical study, Transition metal ions.

PP-45

Hydrogen bonded complexes of 4-pyridylbenzylidene-4�-chloroaniline with 4-alkoxybenzoic acids and their mesomorphic thermal stabilities

N. Anusha Padiyar, Deepak, Aparna Prasad D and Maddasani Srinivasulu*

Department of Chemistry, Manipal Institute of Technology

Manipal University, Manipal – 576104

s.maddasani manipal.edu

A new series of hydrogen bonded (HB) complexes are prepared using a new proton acceptor, 4-

pyridylbenzylidene-4�-chloroaniline (PyBC) with mesomorphic 4-alkoxybenzoic acids. The 4-

alkoxybenzoic acids (nOBA) are inherently mesomorphic. The lower homologues of nOBAs are exhibiting

the nematic mesophase whereas the higher homologues exhibiting the nematic and smectic-C

mesophases. The HB complexes of PyBC with nOBAs are found to exhibit nematic and smectic-A

mesophases. The smectic-C mesophase exhibited by the higher homologues of the nOBAs is quenched

and smectic-A mesophase is induced in the HB complexes. All the HB complexes are characterized by

Fourier Transform Infrared spectroscopy (FTIR). The mesomorphism exhibited by the HB complexes are

studied using a polarizing optical microscope (POM) attached with a hot stage. The phase transition studies

are carried out by Differential Scanning Calorimetry (DSC). The thermal stabilities of the new HB complexes

are discussed in the wake of the available literature.

PP-46

67

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CHydrogen bonded complexes of 4-pyridylbenzylidene-4�

CHydrogen bonded complexes of 4-pyridylbenzylidene-4�with 4-alkoxybenzoic acids and their mesomorphic thermal stabilities

Cwith 4-alkoxybenzoic acids and their mesomorphic thermal stabilities

, Deepak, Aparna Prasad D and Maddasani Srinivasulu*C, Deepak, Aparna Prasad D and Maddasani Srinivasulu*

Department of ChemistryCDepartment of Chemistry, Manipal Institute of TC, Manipal Institute of T

Manipal UniversityCManipal University

SHydrogen bonded complexes of 4-pyridylbenzylidene-4�SHydrogen bonded complexes of 4-pyridylbenzylidene-4�with 4-alkoxybenzoic acids and their mesomorphic thermal stabilitiesSwith 4-alkoxybenzoic acids and their mesomorphic thermal stabilities

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Synthesis and characterization of pyrazole-coumarin hybrid1 1 2 1

Santhosh Prabhu , Suchithra M Shetty , Shivaprasad Shetty , and N V Anil Kumar *1 Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal-576104

2 Department of Chemistry, NMAMIT, Nitte

The pyrazole derivatives were extensively studied for many applications including anticancer, anti-

inflammatory and anti-glycemic activities.Pyrazole coumarin hybrid was synthesized from ring closure of

coumarin chalcones, which in turn, was obtained from acetyl coumarin and different aldehydes. The acetyl

coumarin was synthesized from salicylaldehyde and ethyl acetoacetate. The compound was characterized 1by H NMR and FTIR spectral data.

PP-47

Synthesis and characterisation of some coumarin schiff bases1 1 2 1*Sujay , Shwetha , Shivaprasad Shetty , and N V Anil Kumar

1Dept. Of Chemistry, Manipal Institute of Technology, Manipal-5761042Dept. Of Chemistry, NMAMIT Nitte

Semicarbazone molecules hold great importance due to their pharmacological properties such as

antibacterial, antifungal, antihypertensive, hypolipidemic, antineoplastic, hypnotic and anticonvulsant. A

large variety of semicarbazones and their complexes shows anti protozoal activity also. Semicarbazones

drags the attention of researchers because of their unusual coordination modes, high pharmacological

potentiality and good chelating property.In present synthesis the Schiff's base was obtained from acetyl

coumarin & different aldehyde semicarbazones. These semicarbazones were synthesized from

corresponding aldehydes and semicarbazide hydrochlorides. The acetyl coumarin was synthesized from

salicylaldehyde and ethylacetoacetate.

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68

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2-Anilinothiazole derivatives as inhibitors of penicillin binding proteins:design, synthesis and characterization

1 2 3UwabagiraNadine , BalladkaKunhannaSarojini *, and Jean BaptisteNkurunziza1Department of Studies in Biochemistry, Mangalore University, Karnataka, India

2Department of Industrial Chemistry, Mangalore University, Mangalaganothri-5741993Department of Studies in Chemistry, Mangalore University,Mangalaganothri-574199.

uwadine5 gmail.com bksaroj35 gmail.com

The prevalence of multidrug-resistant strains of bacteria has become a serious problem all parts of the 1world. A particular concern is the misuse or overuse of antibiotics, which has increased the rate of infectious

diseases. Although several classes of antimicrobial drugs such as cephalosporins, penicillinsare currently

available, there is still a critical need to design and develop new pharmacologically active compounds as

promising antimicrobial agents. Many microbial enzymes were reported to be key target for many

antibiotics. These include glucosamine-6-phosphate synthase, DNA gyrase, penicillin-binding proteins,

dihydropteroate synthase, etc.Thiazole and its derivatives have been used as potent lead compounds for 2the synthesis of many active drugs such as niridazole, sulfathiazoleand fanetizole. In addition,

aminothiazole analogues exhibit a broad spectrum of biological activities such as antifungal, antibacterial,

antioxidant, anti-inflammatory and anticancer properties.Keeping in view of the above observations,

docking study was undertaken to design new biologically active compounds as inhibitors of bacterial

penicillin-binding proteins. The designed compounds 2-anilinothiazole derivatives are synthesized by

condensation of different a-haloketones with phenylthiourea via Hantzsch method. The structures of the 1newly synthesized compounds are elucidated on the basis of their IR, H-NMR, mass spectral and analytical

data. In order to support the in silico study results, all the newly synthesized compounds are further

screened for their in vitro antibacterial activity.

Keywords: 2-Anilinothiazole Molecular Docking Antimicrobial property

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antibacterial

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ICET2-Anilinothiazole Molecular

ICETMolecular Docking Antimicrobial

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compounds Scompounds 2-anilinothiazole S2-anilinothiazole

phenylthiourea Sphenylthiourea

basis Sbasis

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One- ot s nthesis o s iro- lo ro ane eri ati es an their iolo i al e aluation

Poor i Tha ur . i a a has ar an ashee

.*Manipal College of Pharmaceutical sciences, Manipal University, Manipal, Karnataka, India-576104e-mail: [email protected]

A series of polysubstituted spiro-cylopropanes have been synthesized in a one-pot sequential domino

cyclopropanation reaction from Meldrum's acid, phenacyl bromide, aromatic aldehydes and pyridine in

acetonitrile with triethylamine serving as a catalyst. Structure conformation was done with data obtained

from NMR, IR and MS spectral evaluations. Further, the synthesized compounds were subjected to

biological evaluation. Antimicrobial studies showed compounds 4o and 4n showed anti-bacterial activity

against Bacillus subtilis NCIM-2063 and compounds 4f and 4g showed anti-fungal activity against Candida

albicans 3100. Cytotoxicity study was also conducted for all the synthesized compounds against vero cell

line study by using MTT assay. All the compounds, except PT-4, 6, 8, 10, 12 and 13 have shown IC50 values

below 200�g/ml. The MTT assay study reveals that the remaining other compounds are considered to be

safe.

PP-50

orrosion inhi ition o urr lea es e tra t on orrosion ontrol o alu inu in h ro hlori a i e iu

Push an ali u a A ao an Pa alatha

Department of Chemistry, Manipal Institute of Technology Manipal University, Karnataka, 576104, India

The work highlights the utility of aqueous curry leaves extract (CLE) as a green inhibitor for the corrosion

control of aluminium in hydrochloric acid medium of pH =2.3. Electrochemical investigation was performed

by varying the inhibitor concentrations in the range of 0.05g L−1 to 0.4g L−1 at five different temperatures

(303K to 323K). Electrochemical studies were performed by potentiodynamic polarizarion technique (PDP)

and electrochemical impendence spectroscopy (EIS) technique. The surface morphology of the material

was studied in the presence and absence of inhibitor with SEM- EDX. Thermodynamic and kinetic

parameters were calculated and discussed in detail. Results were fitted into an appropriate adsorption

isotherm. Suitable mechanism was proposed for the corrosion inhibition process. Inhibition efficiency of

CLE increased with increase in the concentrations of the inhibitor and decreased with increase in

temperature. CLE functioned as anodic type of inhibitor at lower concentrations and as a mixed type at

higher concentrations. It adsorbed on the metal surface both through physisorption and chemisorption and

obeyed Langmuir adsorption isotherm. Surface studies confirmed the adsorption of the inhibitor molecule

on the surface of the metal. Results obtained by both the methods were in good agreement with one another.

CLE is a green inhibitor with lots of environmental and economic benefits.

e or s Aluminum, Green inhibitor, Potentiodynamic polarization, EIS studies, SEM- EDX.

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ole ular o in ase a roa h or the esi n o no el ole ules as inhi itor o eta-h ro a l-a eh ratase ha a o le

1 2u hi er a an alit u ar

1 2Department of Pharmaceutical Chemistry, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar – 576 104, Manipal, Udupi,

Karnataka, India. [email protected]

Tuberculosis is a chronic infectious disease caused by mycobacterium tuberculosis affecting millions of

people worldwide. Resistance of mycobacterium towards drug (MDR, XDR and TDR) has further made the

situation pathetic by decreasing the potency and efficacy of the drug regimen.

Purpose of the study: Currently the drug regimen used for tuberculosis patient contains first line and second

line drugs but resistance towards some of these drugs reduces their efficacy towards the mycobacterium.

As per the literature flavones have been found to show good activity against mycobacterium tuberculosis.

Hence in the present research work we have tried to design some flavones analogues using molecular

modelling software which could prove to be potent for tuberculosis. For docking purpose, the 3-dimensional

structure of 4RLT was retrieved from the Protein Data Bank, prepared and docked with designed flavones

using Schrodinger software. The protein contained co-crystallized ligand 3,7,3 ,4 Tetrahydroxyflavone and

all the novel molecules were docked at that particular site only to compare the interaction between ligand

and residue. About ten flavone molecules were docked against beta-hydroxyacyl-ACP dehydratase HadAB

complex and also their ADME properties were predicted using Quik prop tool of schrodinger software.

Almost all the flavones showed the best binding affinity with good docking score comparable to the originally

bounded flavone molecule. As per the results obtained it is evident that these molecules can be considered a

good candidate for further synthesis and evaluation.

e or s Docking; flavonoid; complex.

PP-52

on u tan e stu on sol ation eha iour o tetra ut l a oniu ro i e in 2-etho ethanol ater i tures at 288.15 - 318.15

1 2ure ha an hi a u ar

Surekha M, Research Scholar, Department of Chemistry, KVG College of Engineering Sullia, D.K.-574327- India.affiliated to Visvesvaraya technological university, Belagavi. [email protected]

Shivakumar H.R. Professor & Head, Department of Chemistry, KVG College of Engineering Sullia, D.K.-574327- India. [email protected]

Precise conductance for Tetra butyl ammonium bromide in 2- ethoxy ethanol + water mixtures containing 0

to 1 mole fractions of 2-ethoxyethanol (XEE) have been measured at 288.15K to 318.15K.The densities,

viscosities and dielectric constants of the solvent mixtures at desired temperatures were reported. The

electrical Conductivity data were analyzed by three major conductivity models such as Shedlovsky, Debye-

Huckel – Onsagar and Kraus-Bray. Limiting molar conductance, Stokes radius,Walden product and

dissociation constant were evaluated for all solvent compositions. Limiting molar conductance (�°m)

decreases with increase in concentration of 2- ethoxy ethanol. Walden product (�°m �0) is found to be

maximum at XEE = 0.0136 for 2- ethoxy ethanol + water mixtures. Thermodynamic relations related to

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solvation were computed by using Born relations. The results obtained from the conductometric

investigations were used to interpret ion-ion and ion-solvent interactions.

e or s Limiting molar conductance; Dielectric constant; Stokes radius; 2-ethoxy ethanol.

An in esti ation on e hani al ear an or holo i al ro erties o are a lea i er- nt-e o an eu atoriu i er- nt-e o rein or e

h ri ol er o osites

1 2u a an hi a u ar

Sujay M M, Research Scholar, Department of Chemistry, KVG College of Engineering Sullia, D.K.-574327- India. Affiliated to Visvesvaraya Technological University Belagavi. [email protected]

Shivakumar H.R. Professor & Head, Department of Chemistry, KVG College of Engineering Sullia, D.K.-574327- India. [email protected]

In recent years, due to environmental concern the use of renewable materials have been gaining

importances in various fields. In this regard the proper utilization of natural fiber in composites material is one

of the advanced technologies improved in engineering and industries. Therefore, we have adopted areca

leaf and eupatorium fibers to incorporate in epoxy resin-CNT mixture. This method of fabrication implies the

formation of hybrid polymer composites. In this work, areca leaf, eupatorium fiber and multiwalled carbon

nanotube were considered as reinforcement material and epoxy resin as matrix phase. The prepared

composites were tested for tensile, flexural, compression, impact strength and wear rate. The surface

morphology was analyzed through Scanning electron microscope and decomposition profile of material

was characterised by thermogravimetric analysis. The results revealed that the properties of hybrid

composites have been improved; this is due to the incorporation of CNT as second reinforcement material in

the composites.

e or s Natural fiber; MWCNT; Epoxy resin.

PP-54

esi nin o hea an e i ient s on e ase su era sor ent or oil- ater se aration

Atanu ha u hen u a ho hur an . . . ar a

Isotope and Radiation Application Division, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre, Trombay, Mumbai-400 085, India.

*To whom all correspondence should be addressed: Tel: +91-22-27887347, e-mail: [email protected]; [email protected]

Abstract: Water contamination by oily substances is an alarming problem in recent times. Separation of

oil–water from either its layered mixtures or emulsions is an extremely important challenge. Modified foam

and sponge based materials are found to be effective in oil-water separation. We introduce a rapid, single

step, scalable, economic and sustainable route to introduce super selectivity towards oily liquid to the

sponge upon modification via gamma radiation assisted grafting of a low surface energy molecule (dodecyl

2-methacrylate). The modification provides a highly durable special wettable property (superhydrophobicity

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and superoleophilicity) to the material without compromising its inherent mechanical property. We

demonstrate that single the 'super'-oil-absorbent (modified PU sponge) is highly efficient to separate quickly

both layered oil–water mixtures and emulsions (micron and submicron size), which is unprecedented in the

literature. Here, the reported material provides an energy efficient and more convenient approach to

separate oil–water from both layered and emulsified oil/water mixture. SEM image indicates the formation of

a rough surface on a modified PU sponge with some micron, submicron and nanosize hemispheres or

bumps (ups and downs) due to the gamma-radiation based grafting of DMA. Moreover, the same piece of

this modified PU sponge can be repetitively used in separation of oil–water for more than 100 times at least

without compromising its mechanical & physical (special wetting) properties.

e or s oil-water; superhydrpophobic; superoleophilic.

nthesis an hara teri ation o so e ne in ole eri ati es or anti an er a ti it usin hitosan nano arti les

1 1 2 3Poo a a ath han a unil anu. ose h A ul A ees A ul ala reele ha 4 5 5

T.T otesh ara i e hate1Department of Chemistry, Manipal Institute of Technology, Manipal University, India.

2Chemical Sciences & Technology Division (CSTD), CSIR - National Institute for Interdisciplinary Science & Technology (NIIST), India.

3Department of Atomic and Molecular Physics, Manipal University, India.4Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer

Centre, India.5Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal

576104, Karnataka, India.

PP-56

Rapid growth of breast cancer patients has become a major threat among developed and developing

countries as it still remains incurable, despite immense efforts are made to untangle numerous tumour

pathophysiology. Though conventional treatment strategies like surgery, radiotherapy, chemotherapy etc.

are feasible for locally progressive or metastatic cancer, they have restraints in patients who subsequently

develop an acquired resistance. The limited potency of existing marketed anticancer drugs entreat for newer

target-specific hybrid molecules to combat cancer. In the quest for synthesising novel anticancer agents we

came across indole and their derivatives that function as potential anticancer agents by inhibiting profuse

anti-apoptotic proteins. Hence in the present investigation indole was cocktailed with various

pharmacologically active moieties such as coumarin, quinoline, oxadiazole, thiadiazole, triazolothiadizole

etc. and six new series of hybrid derivatives were synthesised aiming to achieve promising response as

anticancer agents. Their chemical structures were confirmed using various spectroscopic techniques such

as IR, 1H NMR, 13C NMR and Mass spectrometery and were screened for their potential as anticancer

agents against MCF-7 cancer cell line. Among them, the most active indole-thiadiazole hybrid 5k was

analysed to study extent of apoptosis using various apoptotic assays. The ability of lead molecules to inhibit

the antiapoptotic Bcl-2 protein by acting as a BH3 mimetic was investigated through in silico docking

studies. Versatile proficiency of nanoparticle to wield the lead drugs and their structures has transposed the

conventional drug delivery system by optimizing efficacy and safety of cancer chemotherapy. Hence using

ionic gelation technique 5k was encapsulated within chitosan and further PEGylated to evaluate the effect of

encapsulation on anticancer activity. Although, through our study, we propose the ability of 5k to act as a

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lead anticancer molecule, auxiliary investigations are warranted to explore the oncological therapeutic effect

of this promising.

e or s Anticancer, Chitosan; In silico docking; Nanoparticles; MCF-7.

eri ental in esti ation o ther o- h si al ro erties o uO/ eioni e ater ase nano ui ole o is ersants

1 1 1aPa ithra . . .P. asho a asiulla

Department of chemistry, Manipal Institute of Technology, Manipal University, Manipal

Email: [email protected]

The present study focus on the effects of dispersant for stability and thermal conductivity of CuO/de-ionized

water based nanofluids as a coolant for heat transfer applications. CuO /de-ionized water nanouids of

different volume fractions with different dispersant mass fractions are prepared by two-step method. The

synthesized nanoparticles were characterized by X- ray diffractometry (XRD), Scanning electron

microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and UV absorption spectroscopic

techniques. The effects of two kinds of dispersants - sodium dodecyl sulphate (SDS) and

polyvinylpyrrolidone (PVP) on the stability and thermal conductivity of CuO/de-ionized water nanouids are

measured by a Hot Disk thermal property analyser (KD2 pro Decogon). Results showed that dispersant

plays an important role in dispersing the nanoparticles into the base uid and improving the stability of

CuO/de-ionized water nanouids. Non-ionic dispersant PVP shows better positive effects than anionic

dispersant SDS on the dispersion and enhancement of thermal conductivity of nanouids.

e or s CuO nanofluids, Dispersants, Concentration ratio, Thermal conductivity

PP-57

nthesis an anti o a terial s reenin o ne hal one eri ati es

Poo a . e ant e e Nitin u ar . hett

Manipal Institute of Technology, Manipal, Karnataka, India-576104


Chalcones and their derivatives proved to be an important molecular scaffold for the search of new

pharmaceutically active molecules. Synthesis of various derivatives of chalcones has gained major attention

due to their application in various field of chemistry. Chalcones act as building block for the synthesis many

heterocyclic ring systems gives worthwhile molecules from the biological point of view. In addition to the

synthetic significance of chalcone derivatives, itself found to exhibit wide range of biological activity.

The present work involves the synthesis of various chalcone derivatives and their evaluation as

antimycobacterial agents. Chalcones were prepared by the Claisen-Schmidt condensation of various

acetophenones and substituted naphthaldehyde in the presence of NaOH as a catalyst. The synthesized

chalcone derivatives were characterized by using IR and NMR spectroscopic techniques. The resulted

chalcones were subjected to antimycobacterial activity against Mycobacterium smegmatis. Most of the

synthesized chalcones have shown moderate to good activity against the species under study.

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Tar etin nthesis o no el ih ro ri i ines an their e aluation or antitu er ular a ti it a ainst o a teriu s i atis

rithi . ha a ath e ant e e Nitin u ar . hett1 2 2

1Poornaprajna College, Udupi - 576 101 2Manipal Institute of Technology, Manipal, Karnataka, India-576104

* [email protected]

Multifunctionalised dihydropyrimidines represent an important class of heterocyclic compounds due to its

widespread therapeutic applications as anticancer, antiviral, antimicrobial agents. Owing to the biological

significance, dihydropyrimidines have gained much attention of many researchers in the field of medicinal

chemistry. Being fascinated by the significance of dihydropyrimidines, we have synthesized novel

dihydropyrimidines using Biginelli reaction between thiourea, substituted naphthaldehyde and various

active methylene compounds. The one pot method includes p-toluene sulphonyl acid as a catalyst and

ethanol as solvent. Structure of synthesized molecules was confirmed by using IR and NMR spectroscopic

analysis. All the compounds were subjected to antitubercular activity study against Mycobacterium

smegmatis. Most of the molecules have shown moderate to good activity.

PP-59

ineti ther o na i an isother stu ies or the a sor ti e re o al o Aura ine-O an u ions usin A l/A O ti i ation

an o ellin a roa h usin arti i ial neural net or s1 1 1. A ith u ar . Aruna e i an . a itha

1P.G. and Research Department of Chemistry, C.P.A. College, Bodinayakanur, Tamilnadu. [email protected]

In this work, the prediction of adsorption efficiency for removal of Auramine-O (Ar-O) and Cu(II) ions onto

AgCl/AC by artificial neural network (ANN) model has been studied. The adsorbent was characterized by FT-

IR, XRD, SEM and EDAX. Effects of pollutant concentration, adsorbent dose, initial pH, agitation speed,

contact time and effect of temperature were investigated. Fitting the experimental equilibrium data to various

isotherm models such as Langmuir, Freundlich, Tempkin and Dubinin-Radushkevich models show the

suitability and applicability of the Langmuir model. Kinetic studies show that the removal percentage was

achieved within 90 min. The adsorption of Ar-O and Cu(II) ions follows the pseudo-second-order with a

combination of intraparticle diffusion model. Besides, the calculated thermodynamic parameters, showed

an exothermic as well as chemical nature through the adsorption process. The model was developed using

a three-layer feed forward back propagation algorithm with 6, 10 and 1 neurons in the input, hidden and

output layers, respectively. The comparison between the model results and experimental data gave a high

correlation coefficient (R2=0.998) and showed that the model is able to predict the removal of Ar-O and

Cu(II) from aqueous solution.

e or s Auramine-O, ANN, adsorption, exothermic

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ali ate s e tro hoto etri etho or the eter ination o et or in h ro hlori e the or ation o har e trans er o le

1 1a allur otta il hanusha a ia a Nara ana

1Department of Studies in Chemistry, Mangalore University, Mangalagangothri-574 199, Karnataka, India. [email protected], [email protected]

Two simple, accurate, rapid and highly sensitive spectrophotometric methods have been developed for the

determination of metformin hydrochloride (MET) in pure and in pharmaceutical formulations. The methods

were based on charge transfer complexation of MET with π-acceptors namely 2, 5-dichloro-3, 6-dihydroxy-1,

4-benzoquinone (CAA) for method A and 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ) for method B,

resulting in the formation of highly colored complexes with maximum absorbances at 520 nm and 460 nm,

respectively. Beer's law was obeyed in the concentration ranges 50.00-300.00 and 20.00-200.00 �g mL-1

with molar absorptivities at 0.0573104 and 0.1366104 L mol-1 cm-1 for method A and method B,

respectively. The described methods were successfully applied to the determination of MET in tablets. The

solid charge transfer complexes of MET with each of the π-acceptor reagent were also synthesized and

characterized by FT-IR spectroscopy.

e or s Metformin hydrochloride; Charge transfer complexation; 2, 5-Dichloro-3, 6-dihydroxy-1, 4-

benzoquinone; 2, 3-Dichloro-5, 6-dicyano-1, 4-benzoquinone.

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nhi ition lero en ru ani ulatu lea es e tra t on the orrosion o stainless steel in Na l e iu

1 2 2halini u a an Pa alatha ao

1Department of Chemistry, Bhandarkars' College, Kundapur, India2Department of Chemistry, Manipal Institute of Technology, Manipal, INDIA

Corresponding author's mail id: [email protected]

Clerodendrum paniculatum L. leaf extract (CPLE) was used as a green inhibitor for corrosion control of

stainless steel in sodium chloride medium. The corrosion inhibition studies were carried using

potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques at the

temperature range of 303 K to 323 K. Surface morphology of the metal was studied using Scanning electron

microscopy (SEM), both in the absence and in the presence of inhibitor. Inhibition efficiency of CPLE

increased with increase in the extract concentration from 50 ppm to 800 ppm and as well as with increase in

temperature. Inhibitor acted as mixed type of inhibitor by controlling both anodic metal dissolution reaction

and hydrogen gas evolution reaction. Kinetic and thermodynamic parameters governing the adsorption

process were calculated and discussed in detail. The adsorption of CPLE on the surface of stainless steel

was evaluated by adsorption isotherm studies. The studies showed that CPLE underwent chemical

adsorption by following Langmuir adsorption isotherm. Results obtained by potentiodynamic polarisation

method and electrochemical impedance spectroscopy method were in good agreement with one another.

SEM studies confirmed the corrosion inhibition of the stainless steel due to the adsorption of CPLE. CPLE

emerged as a biodegradable, environmentally benign green inhibitor with minimal health and safety

concerns. It is a potential, cost effective alternative to synthetic corrosion inhibitors.

e or s Stainless steel, Potentiodynamic polarization, EIS, adsorption isotherm, SEM-EDX

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ltrasoun assiste reen etho or the s nthesis o 2-a ino-4 -hro enes usin P A

. anthara u an Prashant . ire ath

Department of Chemistry, Rani Channamma University, Belagavi, P-B, NdH-4-591156, Karnataka.* Email: [email protected]

2-Amino-4H-chromenes are an important class of heterocyclic compounds having important diversified

biological activities. Since from last decade, these compounds had shown interesting pharmacological

properties in the medicinal field. A number of methods have been developed, however most of them were

carried out in various catalysts method, organic solvent as well as in thermal conditions and created much

environmental hazardous. As an environmental consciousness in chemical research and industry has

increased, efficient, economic, and clean procedure has been received increased attention in recent years.

Multi-component reactions (MCRs) constitute an especially attractive synthetic strategy for rapid and

efficient library generation due to the fact that the diversity can be achieved simply by varying the reacting

components. A simple and environmentally benign synthesis of 2-amino-4H-chromene is described using

WEPBA (Water extract of papaya bark ash) as a green basic catalyst in aqueous medium. The catalytic

nature of the catalyst acting as a base as well as a solvent make the present protocol sustainable and

advantageous compared to conventional methods.

Herein, we have developed an eco-friendly method for the synthesis of 2-amino-4H-chromenes, reaction

between various substituted aldehyde, malononitrile and resorcinol/naphthols in the presence of WEPBA at

room temperature under ultrasound about 50-60min. To our knowledge, WEPBA is the first of its kind used in

the synthesis of 2-amino-4H-chromenes. Compared with the classical heating reactions, the main

advantages of the procedure are eco-friendly protocol, milder reaction condition, green catalyst, better yield

and easier workup. Further, recrystallized 2-amino-4H-chromene derivatives have been characterized by FT-

IR, 1H-, 13C-NMR and mass spectrometry.

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in le an ultila ere su er a a itor ele tro es ase on o osites o ar on i re an ol aniline

o a an . el a u ar

Department of Chemistry, Manipal Institute of technology, Manipal University, Manipal

576 104 Karnataka, India.

*Tel: (0): 91 820-2924412; Fax: 91 820-2571071 E-mail address: [email protected]

The single and multilayered electrode materials based on composites of carbon fibre and polyaniline were

prepared. The effects of three different electrolytes like sulfuric acid, p-toluene sulphonic acid and camphor-

10-sulphonic acid on the charge capacitance behavior of electrodes were studied. The electrode materials

were prepared by taking stainless steel as the substrate using potentiodynamic technique. The electrode

materials were characterized using SEM and FTIR. The supercapacitor behavior of these single and

multilayered electrode materials were analysed using cyclic voltammetry, ac impedance and charge-

discharge cycling techniques. It was found that multilayered electrode material showed good

supercapacitive behavior than their single layered counterparts.

e or s Supercapacitor; Polyaniline; Carbon fibre; Potentiodynamic

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el -asse le is oti li ui r stals

A arna Prasa an a asani rini asulu

Department of Chemistry,Manipal Institute of Technology, Manipal University, Manipal – 576104.

A new symmetrically substituted discotic core of phloroglucinal derivative with pyridine moiety as a proton

acceptor is synthesised and characterised. The 4-n-alkoxybenzoic acids are used as the proton donors.

The ternary mixtures (1:3 molar ratio) of proton donor and acceptors are prepared and studied their

mesomorphism. The presence of Hydrogen bonding (HB) in the mixtures are characterized by FT-IR

spectroscopy. The mesomorphism in these mixtures are investigated using a polarizing optical microscopy

(POM) attached with a hot stage. The phase transition temperatures and the enthalpy change values across

the phase transitions are determined by using Differential Scanning Calorimetry (DSC). The structure -

property relationships have been discussed in this series of compounds.

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le tro he i al er or an es o nano os2/a ti ate ar on su er a a itor

1 2an eetha . N. an . el a u ar

Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal, India – 576104

Email: *[email protected]

The past few years have witnessed a surge of interest in the development of several materials for potential

application in supercapacitor devices. Activated Carbon (AC) and MoS2 fall into the category of EDLC and

pseudocapacitor materials. The present work involves, the synthesis of AC from cheap, environmental

friendly, waste precursor leaf.2 The carbonised leaf is mixed with the KOH and sonicated for 20 hours.

Followed by annealing at 650 °C for activation. The synthesised AC shows high surface area of 1500 m2g-1.

Hydrothermal process was involved in the synthesis of nano-structured MoS2.3 XRD confirms the mixed

phases - 1-T and 2-H of MoS2. Composites of AC and MoS2 of different ratios were prepared by polymer

blending technique and its characterised by cyclic voltammetry and AC impedance study. The AC/MoS2

with good conductivity ratio is selected for supercapacitor application studies. AC/MoS2 composite showed

enhanced specific capacitance compared to bare AC or MoS . 2

e or s Supercapacitor; Electric-double layer; Pseudocapacitance; Activated Carbon.

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nthesis o i era ine eri e uaternar a oniu anti i ro ial sur ers

. . anohar .P. asho a

Department of chemistry, Manipal Institute of Technology, Manipal-576104.

*+91-8147-419-027; [email protected]

Diseases and infections caused by pathogenic microbes in human beings, plants and animals have long

been warning to human health and social development. One-fourth of the deaths are caused by infectious

diseases globally (Fungi, bacteria and virus). Many kinds of antimicrobial agents, including disinfectants

and antiseptics, antibiotics have been evolved to fight with pathogenic microbes. Antimicrobial polymeric

materials are those which are capable of inhibiting or killing microbial growth on a surrounding environment

or surfaces. The present research work focuses on synthesis of new piperazine derived surfmer. All reactions

were performed using water as a solvent in a one pot synthesis approach. The obtained surfmer then

characterized by FTIR and NMR towards their structural confirmation. And the antimicrobial properties of the

materials were carried by standard procedures.

e or s N- Ethyl piperazine; Surfmer; Antimicrobial activity

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iosor tion o ia inon esti i e ro ater usin nano ellulose

1 2 3 4Nira asani A it han h ara a ha a Anil u ar a i u ar ha a an Thorat

Marine Biotechnology & Ecology Division,CSIR- Central Salt & Marine Chemicals Research Institute,G.B. Marg, Bhavnagar- 364002, Gujarat, India.

*Corresponding Author: Dr. RB Thorat (+91 94268 56122 and [email protected])

Diazinon is an organophosphate insecticide and has a detrimental effect on the human health and causes

severe environmental hazards. This study explores the chances of biosorbing diazinon using nanocellulose

(NC) from aqueous solutions under batch mode. The biosorption equilibrium revealed that 1.0 (g/L) NC

mops 0.2-1.0(mg/L) diazinon under controlled agitated condition. The residual concentration of diazinon

was quantified using spectrophotometer and chromatographic techniques. The finding demonstrates that

NCs could effectively mop the pesticides present in the water.

e or s Biosorption; Diazinon; Nanocellulose; Kinetics

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A li ation o res onse sur a e etho olo o - ehn en esi nor o er a sor tion a ro aste

. eerthi an eena u ara A i

P.G Department of Environmental Engineering, Civil Engineering Department

Bapuji Institute of Engineering and Technology, Davanagere 577004, Karnataka, INDIA

e-mail: *[email protected]

The common agro waste namely Rice husk and coconut husk were used for the adsorption of copper .The

influence of three variables viz., initial copper metal ion of concentration (10,55,100 ppm) , contact time

(2,13,24 hrs) and adsorbent dosage (0.2,0.6,1 gms) were investigated. The optimal combinations of

variables were investigated by RSM, Box-Bekhen design. The second order equation gives the most efficient

relationship between the response and variables. The optimum condition for maximum adsorption 87.59%

of copper by rice husk were 24 hrs, 55 ppm, 1 gms. The optimum condition for maximum adsorption

95.6245% of copper by coconut husk were 2 hrs, 10 ppm, 0.6 gms.

e or Rice husk; Coconut husk; Response Surface Methodology; Box-Behnken design;

Copper; Heavy metal

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etero li ri ile e e i inal s a ol s a on er ent route usin nano r stalline no as atal st

1 1 2A. a ashree . Nara ana an . . aro ini1Department of Studies in Chemistry, Mangalore University,

Mangalagangothri-574 199, Karnataka, India.2Department of Industrial Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India

[email protected], [email protected], [email protected]

Heterocyclic privileged medicinal scaffolds involving 1,2-dihydropyrazolone and imidazole frameworks are

synthesized by a simple one pot four component cyclocondensation of benzil, aromatic aldehyde,

antipyrine and ammonium acetate in glacial acetic acid using nanocrystalline ZnO catalyst at moderate

temperature. Synthesized products were characterized by FT-IR, 1HNMR and single crystal XRD

techniques. Short reaction time, easy work up, cost effectiveness and recyclability of catalyst, moderate

temperature, good to excellent yields, purification of product by non- chromatographic method, etc are

some of the key advantages of this protocol.

e or s Multicomponent reaction; aldehyde; benzil; ammonium acetate; antipyrine; nanocrystalline

ZnO

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o in stu ies or e loration o otential anti-an ro en a ti it o 3 4 - eth len io a eto henone a ainst Prostate iseases

1 1 2 3A hishe hah i har o o Nan a u ar an Ara in a Pai

1 2 3Department of Pharmacognosy, Department of Pharmacology, Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal - 576104

[email protected], [email protected], [email protected], [email protected]

Prostate cancer (PCa) is the second most common malignancy amongst men worldwide . As per current

cancer statistics, the total number of reported new cases and deaths from Prostate Cancer in the United

States are 180890 and 26120 respectively . The available drugs used for the clinical management of PCa

have limitations like acute and long term toxicities and drug resistance in patients. Human androgen

receptors (1E3G) has been exploited as a main therapeutic target for PCa. Alteration in the functions of

androgen receptors is associated with the prostatic diseases. Therefore, we have investigated molecular

docking studies on the derivatives of Phyto molecule as 3`, 4`-Methylendioxy acetophenone on Androgen

receptor. The three-dimensional structure of Human AR was retrieved from the Protein Data Bank with PDB

ID: 1E3G. Molecular docking studies were performed using Maestro Molecular Modeling platform (version

10.5) by Schrӧdinger, LLC. The steps followed were 1. Ligand preparation . 2. Protein preparation and grid

generation. 3. Ligand Docking. The bound ligand was selected for root mean square deviation (RMSD)

calculations. The docking score was found to be -7.7 and glide energy was -29.395. The RMSD was

calculated and found to be 0.1236. The supporting in vitro and in vivo studies reveal that 3`, 4`-

Methylendioxy acetophenone could be possible treatment option for the prostatic diseases.

e or s Docking; Prostate Diseases; 1E3G; anti-androgen activity

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ole ular na i s si ulations o a ino a i s in o-sol ents

1 1ili . .N an e ashree ha ra ort

Department of Chemistry, National Institute of Technology - Karnataka,

Surathkal, Mangalore - 575025. [email protected], [email protected]

Glycine (NH2CH2COOH) is the simplest of the naturally occurring amino acids, containing a nonpolar side

chain. It is also an active pharmaceutical ingredient having several applications in pharmaceutical industry.

In neutral aqueous solution, glycine exists in the zwitterionic form as H3N+CH2COO -, whereas in gas

phase it exists in nonzwitterionic or neutral form as NH2CH2COOH. A molecular dynamics simulation has

been carried out with both zwitterionic and nonzwitterionic form of glycine in aqueous solution with water as

solvent and methanol as co-solvent with varying the percentage composition of solvent:co-solvent mixture.

This simulation was carried out involving molecular dynamics in canonical ensemble. In order to gain a

fundamental insight, we have analysed the structural and dynamical properties of the system. The structural

properties of the system are investigated by radial distribution functions, number of hydrogen bonds, angle

distribution. Among the dynamical properties we have calculated the hydrogen bond dynamics of the

system.

e or s Glycine; Structure dynamics; angle orientation profile; Hydrogen bond.

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ra hiti ar on nitri e in or orate aTiO3 u oi s as a hoto atal st1 2

arsha an . rishna hat


National Institute of Technology Karnataka, Surathkal, Srinivasnagar-575025, India


With the perpetual industrialization, the environmental pollution has become one of the most serious

problems all over the world. Hence it is imperative to fix this environmental pollution crisis. Photocatalysis, as

a research area has been considered as one of the supplicating options for the treatment of waste water due

to its great potential and high efficiency by using sunlight. Undeniably, the first generation photocatalyst

TiO2 is a prominent catalyst under UV irradiation and its photocatalytic activity was hampered under visible

light (major portion of solar spectrum) due its wide band gap of 3.2 eV. Perovskite titanates (ATiO3) are well

known semiconductors with exciting properties in ferroelectricity, magnetism, semi/super conductivity,

catalysis and so on. CaTiO3, the founding father of the perovskite family is an attractive candidate in various

practical applications such as material sciences, electronic engineering and so on. CaTiO3 is also a

potential photocatalyst in the removal of recalcitrant organic pollutants because of its chemical stability, low

cost and biocompatibility. However its photocatalytic activity in visible light is restricted due to its wide band

gap of 3.65 eV. Therefore, there is a need for extending visible light activity of CaTiO3. A number of

modification routes have been employed to extend the visible light response of CaTiO3 namely ion doping,

coupling with a narrow band gap semiconductor etc. g-C3N4, a metal free polymeric semiconductor

exhibits several phenomenal physical and chemical properties such as optical and electronic properties.

Moreover g-C3N4 has been found to be a prominent catalyst under visible light for the degradation of

organic pollutants due to its band gap of 2.7 eV. To the best of our knowledge there has been no work

devoted to the photocatalytic activity of CaTiO3- g-C3N4 composite. Herein we report the synthesis of

CaTiO3- g-C3N4 composite by a simple mixing-calcination method. The composite exhibited higher

photaocatalytic activity as compared to bare CaTiO3 and g-C3N4. This enhanced photocatalytic activity is

ascribed to the formation of heterojunction between CaTiO3 and g-C3N4.

e or s Photocatalysis;Perovskite titanates;Heterojunction;Doping

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Theoreti al stu ies o ele troni an o ti al ro erties or so e ne a o is erse es or e- ensiti e olar ells s usin T

an T T etho

Nu ur uren ra a u saa Ono a an ohn . a an ara

Department of Chemistry, College of Natural and Mathematical Sciences,

The University of Dodoma, Post Box: 338, Dodoma, Tanzania.

[email protected]; [email protected]

Research in renewable energy has become one of the most imperative issues in global energy strategy due

to increased energy consumption and limited fossil resources. The incident solar energy on earth per hour

exceeds the current consumption of the energy of the world per year. The necessity of cultivating renewable

energy sources is growing day by day. Therefore, efficient solar energy conversion provides a promising

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technology for balancing the increasing energy demand due to fast industrial development. New

photovoltaic (PV) energy technologies can contribute to environmentally friendly, renewable energy

production, and the reduction of the carbon dioxide emission associated with fossil fuels and biomass. Dye-

sensitized solar cells (DSSC) are promising low-cost molecular photovoltaic devices that have a good

chance to become a competitor for solar cells based on technology of p-n junction. One of the key

components of DSSC is a dye, which is responsible for the capture of light. The main goal of this research is

to compare adsorption properties of new azo disperse dyes on titanium dioxide (TiO2). The ground states

geometries, absorption wavelengths, oscillation strengths of new azo disperse dyes such as 3-

aminopyrazoleazo -4-thiol-2,3,5-thiadiazole (D1), 3-amino-4-methylpyrazoleazo-4-thiol-2,3, 5-thiadiazol

(D2), 2, 4-dihydroxybenzeneazo-4-thiol 1-2, 3,5-thiadiazole (D3), 4-amino-3-benzonitrileazo-4-thiol-2,3,5-

thiadiazole (D4), 2-hydroxylnaphtholazo-4-thiol-2,3,5-thiadiazole (D5) and 2-amino-5-ethylcarbazoleazo-4-

thiol-2,3,5-thiadiazole (D6) have been optimized by using density functional theory (DFT) at B3LYP level of

theory with 6-31G(d) basis set. The excitation energies have been computed by using time dependent

density functional theory (TD-DFT). The study of structural, electronic and optical properties for these dyes

could help to design more efficient functional photovoltaic organic materials. The electron injection

(�Ginject), electron coupling constants (|VRP|) and light harvesting efficiencies (LHE) of studied dyes and

have been discussed with esteem to DSSCs. This theoretical designing will the pave way for

experimentalists to synthesize the efficient sensitizers for solar cells.

e or s azo disperse dyes, TD-DFT, electronic and optical properties and light harvesting efficiencies

tu o a neti iel e e t on ele tro e osition o Ni- o allo or i ro e orrosion rote tion

A shatha hett an A. hitharan an e e

Electrochemistry Research Lab, Department of Chemistry

National Institute of Technology Karnataka, Surathkal, Srinivasnagar-575025, India


*Fax: 0824-2474033, Mobile: 9980360242, Phone: 0824 - 2473201 (O)

A stra t The corrosion protection efficacy of Ni-Co alloy coatings were tried to improve by

magnetoelectrodeposition (MED) approach. The magnetic field of varying strength (B) was applied both

parallel and perpendicular to the direction of diffusion of metal ions, simultaneously to the process of

deposition. The corrosion behaviour of the coatings studied through electrochemical DC method revealed

that MED of Ni-Co alloys are more corrosion resistant than their conventionally electrodeposited (ED)

counterpart. Moreover, the effect of magnetic field is more pronounced in case of perpendicular field than

parallel field, explained by Lorentz force. Under optimal condition, MED Ni-Co alloy coating deposited at B=

0.3T (Perpendicular) is found to be 8 times more corrosion resistant than its ED alloy (B= 0T), deposited

from the same bath for same duration. Improved corrosion resistance of MED Ni-Co alloy coatings were

attributed to an increase in the limiting current density (iL) of Co+2ions. The effect of magnetic field on

improved corrosion resistance have been investigated in terms of their changed surface morphology,

composition and phase structure using Scanning electronmicroscopy (SEM), Energy dispersion

spectroscopy (EDS) and X-Ray diffraction (XRD) technique, respectively.

e or s Magnetoelectrodeposition; Ni-Co alloy; Corrosion behaviour; SEM/XRD

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toto i it stu ies o 7-A ino-2-st r l hro one analo ues

1 2alitha i on . rini asan

1Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal, 576 1042 Department of Chemistry, Shri Madhwa Vadiraja Institute of Technology & Management,

Bantakal, Udupi, 574115 Email:[email protected]

A T A T 7-Amino-2-styrylchromones were synthesized from 7-amino-2-methylchromone by

condensing it with various substituted aromatic aldehydes.The cytotoxicity of the synthesized molecules

was assessed against two cell lines, MCF-7 and HCT-116 by MTT assay. (E)-7-Amino-2-(3,4-

methylenedioxystyryl)-4H-chromen-4-one (ASC-9) with IC50 56.0 �M was found to be the most potent

molecule against MCF-7. Cell cycle analysis of the most potent molecule ASC-9 was carried out. ASC-9

induced G0/G1 phase arrest of MCF-7.

e or s 7-Amino-2-styrylchromone, cytotoxicity, MTT assay, flow cytometry

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tu o erosion orrosion on alu inu allo su er e et i in e ent te hni ue

1 2 1a an a Pa alatha ao an a a han ra urth

1Department of Biotechnology, MIT, Manipal University, Manipal, INDIA2Department of Chemistry, MIT, Manipal, Manipal University, INDIA

Corresponding author's mail id: [email protected]

Erosion corrosion is a highly detrimental process which has a significant negative impact on the

performance of industrial systems and was ranked as the fifth most important degradation mechanism in the

offshore and chemical sectors. Erosion corrosion is the conjoint action involving corrosion and erosion in the

presence of a moving corrosive fluid, leading to accelerated loss of material. Upon fluid flow the passivity that

is developed on the aluminum alloy in the static condition cannot be maintained and hence the corrosion

process dominates. In view of the above, test rig was designed for the study of erosion corrosion of

aluminum alloy by weight loss. Studies were carried out with test coupons of 12mm diameter and length

15mm. The slurry consisted of artificial sea water prepared as per ASTM standards and sand (180µ) as solid

suspended mass. Experiment was carried out by varying parameters like temperature (303-313K), time

periods (30 and 60 minutes) and flow rates (4,8 and 12 lpm). There was an appreciable change in the mass

loss with an increase in the time duration. But when the study was conducted for a lesser time duration even

though there was increase in temperature no significant mass loss was observed. With an increase in the

velocity, the erosion corrosion rate also increased.

e or s erosion corrosion; weight loss; aluminum alloy

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Anti- a terial a ti it o nthesi e in o i e nano arti les Assiste i roo en etho

1 2 3 4N. ho ha N. Nan a Puneeth u ar . .Na hushana

1Department of Chemistry, Maharanis Science college for women, Bangalore 560 001 India2Department of Chemistry BMS College for Women, Bangalore560004, Karnataka,India.

3Department of Chemistry ,Sambhram Institute of Technology ,Bangalore.560097,India4Department of Chemistry, M.S. Ramaiah Institute of Technology, Bangalore- 560054, India

Corresponding authors: [email protected], [email protected]

A T A T Zinc Oxide nanoparticles prepared by using zinc acetate as a precursor in aqueous solution

using poly ethylene glycol (PEG) as a surfactant and NaOH as reducing agent with micro oven irradiation

method . The synthesized nanoparticles were characterized by powder X-ray diffraction (PXRD), scanning

electron microscopy (SEM), UV-visible spectroscopy (UV-Vis) techniques. The average particle size of ZnO

was estimated using Scherrer's and found to be in the range nano range. PXRD revels that all the diffraction

peaks were well indexed to pure hexagonal wurtzite ZnO (JCPDS card no. 36-1451) phase. PEG used to cap

the product for studying the influence on the morphology and properties of the nanoparticles. Resazurin 96

well assay was used to assess the minimum inhibition concentration (MIC) of synthesized ZnO

nanoparticles was evaluated.

e or s Antibacterial , Resazurin 96 Well assay, ZnO nano particles, XRD, PEG

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85

No el so a oline-1 2 4-o a ia oles nthesis hara teri ation an Anti i ro ial s reenin

a. . esha . hri e i o a ani an N. ri anta urth

a Department of Chemistry, Yuvaraja's College, University of Mysore, Mysuru-570 005.bDepartment of Studies in Chemistry, University of Mysore, Mysuru -570 006.

cDepartment of Chemistry, Vidyavardhaka College of Engineering, Gokulam, Mysuru -570 002.

Literature study reveals that, a large variety of pyrazole, isoxazole, oxadiazole and thiadiazole containing

heterocyclic moieties show anti-tumor, anti-HIV, antihepatitis, anti-inflammatory, analgesic, antidiabetic,

antituberculosis, antidepressant activity and also used in the treatment of Alzheimer's disease. Fortified by

these reports, we have synthesized 5-substituted-3-(3-substituted-4,5-dihydroisoxazol-5-yl)-1,2,4-

oxadiazole (Fig.1) and studied antimicrobial activities. The target compounds were synthesized by treating

benzaldehyde oxime with acrylonitrile in presence of Chloramine-T to give isoxazoline, then the isoxazoline

is treated with hydroxylamine hydrochloride, followed by acid chlorides and POCl3 to give corresponding

1,2,4-oxadiazole. The newly synthesized compounds have been characterized by elemental analysis and

spectral studies.

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PP-80e o al o lea an er ur ro aste ater usin

Pol hen lsul one / ulti alle ar on nanotu e o osite ultra iltration e ranes

a a han ra he har Na a Arun sloor an A. . s ail

aMembrane technology Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore-575 025, India

bAdvanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia

A stra t Membranes based on carbon nanotubes (CNTs) have been highlighted as an emerging

technology for water purification system applications. Multi walled Carbon nanotube (MWCNT)/

Polyphenylsulfone (PPSU) blend membranes were synthesized via the phase inversion method. The cross

sectional images of resultant PPSU-MWCNT composite membranes were characterized by Scanning

electron microscope (SEM). Hydrophilicity of the membranes was assessed by Contact angle, Porosity,

and Water uptake studies assessed by gravimetric analysis. The pure water flux, and the protein bovine

serum albumin (BSA) rejection experimentations of membranes were carried out under same effective

conditions. The membranes showed enhanced permeability, and antifouling property with the addition of

MWCNT to the PPSU polymer. This study mainly deals with the removal of lead (Pb), and mercury (Hg) ions

from wastewater. In experimental results, the PCNT-4 membrane showed heavy metal ion removal efficiency

for lead 98.13%, and for Mercury 76.12%.

e or s Polyphenylsulfone, Multi walled Carbon nanotubes, Phase-inversion, Antifouling,

Hydrophilicity, Heavy metal ion removal.

86

ICET

han ra he har Na a

ICET

han ra he har Na a

Membrane technology Laboratory

ICET

Membrane technology Laboratory, Department of Chemistry

ICET

, Department of ChemistryKarnataka, Surathkal, Mangalore-575 025, India

ICET

Karnataka, Surathkal, Mangalore-575 025, IndiaAdvanced Membrane T

ICETAdvanced Membrane Technology Research Center (AMTEC), Universiti T

ICETechnology Research Center (AMTEC), Universiti TAdvanced Membrane Technology Research Center (AMTEC), Universiti TAdvanced Membrane T

ICETAdvanced Membrane Technology Research Center (AMTEC), Universiti TAdvanced Membrane T

Malaysia, 81310 Skudai, Johor Bahru, Malaysia

ICETMalaysia, 81310 Skudai, Johor Bahru, Malaysia

Membranes

ICETMembranes based

ICETbased on

ICETon carbon

ICETcarbon

a

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at

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te

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er

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r p

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pu

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ur

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ri

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if

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ic

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at

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ti

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n s

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sy

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y

olyphenylsulfone

ICET

olyphenylsulfone (PPSU)

ICET

(PPSU) blend

ICET

blend membranes

ICETmembranes

images

ICET

images of

ICET

of resultant

ICET

resultant PPSU-MWCNT

ICET

PPSU-MWCNT

microscope

ICET

microscope (SEM).

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(SEM).

ater ICET

ater uptake ICET

uptake studies ICET

studies

albumin ICET

albumin (B ICET

(BSA) ICET

SA)

membranes ICET

membranes

Col hen lsul one / ulti alle ar on nanotu e o osite

Col hen lsul one / ulti alle ar on nanotu e o osite

ultra iltration e ranes

Cultra iltration e ranes

a

Ca

han ra he har Na aC han ra he har Na a Arun sloorC Arun sloor

, Department of ChemistryC, Department of ChemistryKarnataka, Surathkal, Mangalore-575 025, IndiaCKarnataka, Surathkal, Mangalore-575 025, India

echnology Research Center (AMTEC), Universiti TCechnology Research Center (AMTEC), Universiti T

Se o al o lea an er ur ro aste ater usin

Se o al o lea an er ur ro aste ater usin

ol hen lsul one / ulti alle ar on nanotu e o osite Sol hen lsul one / ulti alle ar on nanotu e o osite ultra iltration e ranesSultra iltration e ranes

Arun sloorS Arun sloor

-201

7analgesic,

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7analgesic,

Alzheimer's

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7Alzheimer's disease.

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d

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75-

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compounds

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7compounds were

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7were synthesized

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7synthesized

give

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7give isoxazoline,

-201

7isoxazoline, then

-201

7then

chlorides

-201

7chlorides and

-201

7and POCl3

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7POCl3 to

-201

7to give

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7give


-201


e o al o lea an er ur ro aste ater usin -201

7e o al o lea an er ur ro aste ater usin

ol hen lsul one / ulti alle ar on nanotu e o osite -201

7

ol hen lsul one / ulti alle ar on nanotu e o osite

PP-81nthesis an hara terisation o ou arin O a ia ole ri

1 1 2 1ouri hetti h etha hi a rasa hett N. . Anil u ar

1Dept. of Chemistry, Manipal Institute of Technology, Manipal-5761042Dept. Of Chemistry, NMAMIT Nitte.*Corresponding author

1,3,4 oxadiazole derivatives are reported to show of broad spectrum of biological activities, which include

anti bacterialconvulsant, antihypertensive, antiepiletic and neurotoxic properties according to the protocals

of antiepilepti drug development.

Coumarian hybrid of 2,5 substituted oxadiazole was synthsized from ring closure of schiff's bases. These

schiff's base was obtained from acetyl coumarian and different aldhydes semicarbazones. The

semicarbazones were synthsized from corresopnding aldehydes and semicarbazide hydrocloride, while,

acetyl coumarin was synthesized from salicylaldehyde and ethylacetoacetate. The hybrids were

characterized by NMR and IR.

PP-82A sor tion o hro iu onto hitosan o er

uili riu Ther o na i s ineti s stu ies1 1 1 1

. ala rishna Pra hu Nith a usan ishra i harth ehta

Chemical Engineering, Manipal Institute of Technology

A stra t Chitosan, a bio polymeric material obtained from chitin - the second most occurring resource in

the natural world was used for removing metal ions from water. The adsorbent, in the form of fine powder was

used for batch studies. The adsorption was carried out in a batch process taking different concentrations of

the metal chromium (VI) ion in aqueous solution with variation in adsorbent amount, pH, agitation time and

temperature. The suitability of the adsorbent was tested with Langmuir and Freundlich isotherms and with

various equilibrium kinetic data. A small amount of chitosan powder (1 gL-1) could remove as much as

88.06% of chromium (VI) in 240 min from a solution of concentration 50 ppm at 303 K. The optimum range of

pH for the adsorption process was 3-4.5 and the natural pH of chromium (VI) solution was 4.8. The

thermodynamic studies suggested that the adsorption was exothermic and spontaneous. The kinetic study

showed that the chromium (VI) adsorption on chitosan was best fitted to the pseudo second order model,

thus suggesting that the adsorption on chitosan was likely to be chemisorption. The adsorbent used showed

great affinity for the Cr (VI) ions and is a promising adsorbent for the removal of chromium from wastewater.

87

ICET

aqueous

ICET

aqueous solution

ICET

solution

adsorbent

ICET

adsorbent

data.

ICETdata. A

ICETA small

ICETsmall amount

ICETamount

240

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ICETmin from

ICETfrom a

ICETa solution

ICETsolution

adsorption

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ICETwas 3-4.5

ICET3-4.5

studies

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studies suggested

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suggested that

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that the

ICET

the

the

ICET

the chromium

ICET

chromium (VI)

ICET

(VI) adsorption

ICET

adsorption

suggesting

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suggesting that

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that the

ICET

the adsorption

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adsorption

affinity

ICET

affinity for

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for the

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the Cr

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Cr (VI)

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(VI) ions

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ions

Cmetal

Cmetal ions

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was

Cwas carried

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solution Csolution with Cwith variation Cvariation

adsorbent Cadsorbent was Cwas tested Ctested Camount Camount of Cof

S usan ishra

S usan ishra

Chemical Engineering, Manipal Institute of T

SChemical Engineering, Manipal Institute of T

obtained

Sobtained from

Sfrom chitin

Schitin

from Sfrom waterSwater. S. The SThe

in Sin a Sa batch Sbatch

-201

7schiff's

-201

7schiff's

s

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semicarbazide

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7semicarbazide hydrocloride,

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7hydrocloride,

o

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7b

A sor tion o hro iu onto hitosan o er

-201

7A sor tion o hro iu onto hitosan o er

uili riu Ther o na i s ineti s stu ies

-201

7uili riu Ther o na i s ineti s stu ies

1

-201

71

usan ishra-201

7 usan ishra i harth ehta-2

017

i harth ehta

Chemical Engineering, Manipal Institute of T-201

7Chemical Engineering, Manipal Institute of Technology-2

017

echnologyChemical Engineering, Manipal Institute of TechnologyChemical Engineering, Manipal Institute of T-201

7Chemical Engineering, Manipal Institute of TechnologyChemical Engineering, Manipal Institute of T

chitin -201

7

chitin - -201

7

- the -201

7

the

PP-83T O O ON N T T O 5- 3-P -4 -1 2 4-

T A O -3 T O O A N 6061 A O N A O ON NT AT ON O O O A

a . a a i ra ha An . . hat

aDepartment of Chemistry, Nitte Mahalinga Adyanthaya Memorial Institution of Technology Nitte-574110, Karnataka, India

bDepartment of Chemistry, Shri Madhwa Vadiraja Institute of Technology and Management, Bantakal, Udupi-574115,Karnataka, India

*E-mail:[email protected]

A stra t Corrosion inhibition characteristics of 5-(3-pyridyl)-4H-1,2,4-triazole-3 thiol on corrosion AA6061

in Hydrochloric acid medium was investigated using weight loss, potentiodynamic polarisation and

electrochemical impedance spectroscopy techniques. The effect of inhibitor concentration and

concentration of the acid media on the inhibitor action was studied. Results obtained showed that inhibition

efficiencies increase with increase in concentration of inhibitor. Potentiodynamic polarisation data indicated

that this inhibitor act as mixed type inhibitor. Adsorption of inhibitor on the alloy surface was preferentially

chemisorption. From Impedance data it is found that the corrosion is controlled by charge transfer process.

5-(3-pyridyl)-4H-1,2,4-triazole-3 thiol acted as a promising, highly efficient, corrosion inhibitor for the alloy

AA 6061 .Quantum chemical parameters were constructed in order to characterise the inhibition

performance of the tested inhibitor.

e or s 5-(3-pyridyl)-4H-1,2,4-triazole-3 thiol,Al-6061 alloy; Weight loss; Electrochemical

measurements; Quantum chemical studies.

PP-84

2- 1 - A O -2- T N A N A OT OA A O O ON N TO O

T N P O P O A

u histira Prith i Preethi u ari P u a A. ao

Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal-576104

A stra t The corrosion inhibition behaviour of 2-[(1H- Imidazole-2-yl)methylidene] hydrazine

carbothioamide (IMHC) on the corrosion of mild steel at different temperatures in 0.25 M phosphoric acid

medium was investigated using potentiodynamic polarization and electrochemical impedance

spectroscopy (EIS) techniques. The inhibition efficiency of IMHC increased with increase in inhibitor

concentration and decreased with increase in temperatures. IMHC acted as mixed type of inhibitor. The

adsorption of IMHC on the mild steel was found to take place through physisorption and obeyed Langmuir's

adsorption isotherm. Suitable mechanism for the inhibition process was proposed and surface morphology

study was carried out using Scanning electron microscopy.

e or s Mild steel, EIS, polarization, acid corrosion, SEM

88

ICET2- 1 -

ICET2- 1 - A O

ICETA O -2-

ICET-2- T N A N

ICET T N A N -2- T N A N -2-

ICET-2- T N A N -2-

OT OA A O O ON N TO O

ICETOT OA A O O ON N TO O

T N P O P O A

ICET

T N P O P O A

ICET

u histira Prith i Preethi

ICET

u histira Prith i Preethi u histira Prith i Preethi

ICET

u histira Prith i Preethi


ICET


T ICET

Th ICET

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e c ICET

co ICET

or ICET

rr ICET

r ICET

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s

carbothioamide ICET

carbothioamide (IMHC) ICET

(IMHC)

Co

Col

Cle

Ce-

C-3

C3 t

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Ch

studies.

Cstudies. S

promising,

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c

Sco

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Sns

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i Sio Sol Sl, S,ASAlSl-S-6S60S06S61S1

-201

7thiol

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7thiol on

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7on corrosion

-201

7corrosion

potentiodynamic

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7potentiodynamic polarisation

-201

7polarisation

o

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otentiodynamic

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. Adsorption of inhibitor on the alloy surface was preferentially

-201

7. Adsorption of inhibitor on the alloy surface was preferentially

corrosion

-201

7corrosion is

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promising, -201

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017

highly efficient, -201

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t -201

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7d i-2

017

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017

or-201

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7d

PP-85A tu on tru tural or holo i al an he i al o ositional

hara ter ation o oil a les o hitra ur a an hi o a istri ts.

1 2 3N NA A A A N. . A AN . . A ANNA

1,2 Department of Physics, Sahyadri Science College, Shivamogga, Karnataka, India 3 Department of PG Studies in Physics, Kuvempu University, Shankaragatta, Karnataka, India

*1 E-mail: [email protected]

A stra t Soil sample analysis of a region is a major factor in determining what types of plants grow in a

certain area. Soil chemical compositional analysis is the inherent capacity of the soil to provide the essential

plant nutrients in adequate amounts and in proper proportions for the plant growth. Soil characterization of a

region is also an important aspect in relation to sustainable agricultural Production. Our aim in this research

work was to analyze the soils of various taluks of chitradurga and Shimoga districts in terms of their

Structural, morphological, and chemical compositional (XRD, SEM, AND EDX) characterization and arrive at

a comparative assessment of the similarities and differences that exist due to regional topography and

climate, and the consequential influence on favoured crop type for harvest, their growth prospects and the

final yield.

e or s SEM, XRD, and EDAX.

PP-86

nthesis hara teri ation on 2-a inothia ole ase a o es1 1a i N athi esha a a

Authors: Ravi. B. N1 , E-mail: [email protected] Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu

University, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, IndiaJathi Keshavayya1* (Professor) E-mail: [email protected]

Department of PG Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India

A stra t In this study, we have made an effort to synthesize 2-aminothiazole based azo dyes by means of

diazotization of 2-aminothiazole followed by coupled with suitable coupling components. The synthesized

azo compounds were characterized by Ultra Violet-Visible (UV), Fourier Transform Infrared (FT-IR), Proton

Nuclear Magnetic Resonance (H1-NMR), Mass spectrometric technique and their antibacterial activities

were also examined in detail.

e or s Azo dye, Diazotization, Pyridone derivatives, Barbituric acid, 2-aminothiazole, antibacterial

activity.

89

ICET

nthesis hara teri ation on 2-a inothia ole ase a o es

ICET

nthesis hara teri ation on 2-a inothia ole ase a o es

ICET

a i N

ICET

a i N

Authors: Ravi. B. N1

ICETAuthors: Ravi. B. N1 , E

ICET, E

Department of PG Studies and Research in Chemistry

ICETDepartment of PG Studies and Research in Chemistry

University

ICETUniversity, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India

ICET, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India

Jathi K

ICET

Jathi Keshavayya1* (Professor)

ICET

eshavayya1* (Professor) Department of PG Studies and Research in Chemistry

ICET

Department of PG Studies and Research in ChemistryUniversity

ICET

University, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India

ICET

, Jnana Sahyadri, Shankaraghatta-577451, Karnataka, India

In

ICET

In this

ICET

this study

ICET

study

ICET

,

ICET

, we

ICET

we have

ICET

have

diazotization ICET

diazotization of ICET

of 2-aminothiazole ICET

2-aminothiazole

azo compounds were characterized by Ultra Violet ICET

azo compounds were characterized by Ultra Violet

Magnetic ICET

Magnetic Resonance ICET

Resonance

Cnthesis hara teri ation on 2-a inothia ole ase a o esCnthesis hara teri ation on 2-a inothia ole ase a o es1C1a i N Ca i N athi C athi

Authors: Ravi. B. N1 CAuthors: Ravi. B. N1 , EC, ESnthesis hara teri ation on 2-a inothia ole ase a o esSnthesis hara teri ation on 2-a inothia ole ase a o es

-201

7 Soil sample analysis of a region is a major factor in determining what types of plants grow in a

-201

7 Soil sample analysis of a region is a major factor in determining what types of plants grow in a

soil

-201

7soil to

-201

7to provide

-201

7provide the

-201

7the

growth.

-201

7growth. Soil

-201

7Soil characterization

-201

7characterization

Production.

-201

7Production. Our

-201

7Our aim

-201

7aim in

-201

7in this

-201

7this

Shimoga

-201

7Shimoga districts

-201

7districts in

-201

7in

AND

-201

7AND EDX)

-201

7EDX) characterization

-201

7characterization

that

-201

7that exist

-201

7exist due

-201

7due to

-201

7to regional

-201

7regional

type

-201

7type for

-201

7for harvest,

-201

7harvest, their

-201

7their

nthesis e tral a neti us e ti ilit tu ies on etri all O ta u stitute etal Phthalo anines

1 1asiulla ar a ith

1Department of Chemistry, MIT, Manipal, Udupi District, Karnataka, India

A stra t Present paper discuss the synthesis and characterization of metal (II) 1, 3, 8, 10, 15, 17, 22, 24-

octa-1-(3-furyl) methanimine phthalocyanines (M-furylImPcO) (M = Cu, Co, Ni, Zn) by an efficient method.

Octaamino metal (II) phthalocyanines were synthesized by the reduction of the corresponding nitro

phthalocyanines. The dark green octa-1- (3-furyl)methanimine phthalocyanine derivatives were

characterized by elemental analysis, magnetic susceptibility, electronic, IR and powder X-ray diffraction

studies to check the purity, structural integrity and crystalline properties of the complexes. Magnetic

susceptibility studies on Co (II) and Cu (II) octa-1-(3-furyl) methanimine phthalocyanine complexes

exhibit a variation of the magnetic moments as a function of field strength indicating the presence of inter

molecular co-operative effect.

e or s Phthalocyanines, Octa-1-(3-furyl)) methanimine, Electronic, IR, Magnetic Susceptibility, XRD,

Thermal.

PP-87

PP-88nthesis an anti o a terial a ti it o no el uina olinone

eri ati es a ainst a teriu s i atis1 2 2

han u a Pri a . e ant e e Nitin u ar . hett

*[email protected] College, Udupi-576101,

2Manipal Institute of Technology, Manipal, Karnataka, India-576104

Quinazolinones constitute an important class of heterocyclic compounds having diverse biological

applications. Biginelli reaction is extensively studied for the synthesis of quinazolinone derivatives. In

present work, Biginelli type condensation of cyclic-1, 3-diketone, substituted naphthaldehyde and thiourea

is studied for the convenient synthesis of new quinazolinone derivatives. The reactions are carried out

efficiently using p-toluene sulphonic acid as catalyst and ethanol as solvent. All the compounds are

characterized with IR and NMR spectral analysis. In vitro antimycobacterial screening is done for all the

molecules and most of the derivatives have shown moderate to good activity against Mycobacterium

smigmatis.

90

ICET

eri ati es a ainst

ICET

eri ati es a ainst

han u a Pri a .

ICET

han u a Pri a . e ant e e

ICET

e ant e e

*[email protected]

ICET*[email protected]

ICET1P

ICETPoornaprajna College, Udupi-576101,

ICEToornaprajna College, Udupi-576101,

Manipal Institute of T

ICETManipal Institute of Technology

ICETechnologyManipal Institute of TechnologyManipal Institute of T

ICETManipal Institute of TechnologyManipal Institute of T

constitute

ICET

constitute an

ICET

an important

ICET

important

Biginelli

ICET

Biginelli reaction

ICET

reaction is

ICET

is extensively

ICET

extensively

work,

ICET

work, Biginelli

ICET

Biginelli type

ICET

type condensation

ICET

condensation

studied

ICET

studied for

ICET

for the

ICET

the convenient

ICET

convenient

efficiently ICET

efficiently using ICET

using p-toluene ICET

p-toluene

characterized ICET

characterized with ICET

with IR ICET

IR and ICET

and

most ICET

most

Cnthesis an anti o a terial a ti it o no el uina olinone

Cnthesis an anti o a terial a ti it o no el uina olinone

eri ati es a ainst

Ceri ati es a ainst a teriu s i atis

Ca teriu s i atis

2 C2e ant e e Ce ant e e

*[email protected]*[email protected]

Snthesis an anti o a terial a ti it o no el uina olinone Snthesis an anti o a terial a ti it o no el uina olinone a teriu s i atisSa teriu s i atis

-201

7corresponding

-201

7corresponding

n

-201

7ni

-201

7in

-201

7ne

-201

7e d

-201

7de

-201

7er

-201

7ri

-201

7iv

-201

7v

and

-201

7and powder

-201

7powder X

-201

7X-ray

-201

7-ray X-ray X

-201

7X-ray X diffraction

-201

7diffraction

properties

-201

7properties of

-201

7of the

-201

7the complexes.

-201

7complexes.

methanimine

-201

7methanimine phthalocyanine

-201

7phthalocyanine

strength

-201

7strength indicating

-201

7indicating the

-201

7the

methanimine,

-201

7methanimine, Electronic,

-201

7Electronic, IR,

-201

7IR, Magnetic

-201

7Magnetic

orrosion nhi ition Pro erties o il teel usin 2- uran-2-l eth li ene ra ine ar othioa i e n 0.5

l e iu1 1 1

ash itha utha a Preethi u ari P u a A ao 1* Department of chemistry, Manipal Institute of Technology,

Manipal University, Manipal, 576104

A stra t The corrosion inhibition behaviour of mild steel in 0.5 M HCl, at different temperatures (30 ºC to 50

ºC) in the presence of 2-(furan-2-ylmethylidene) hydrazine carbothioamide (FMHC) was investigated using

potentiodynamic polarization, SEM and electrochemical impedance spectroscopy techniques. The

inhibition efficiency of FMHC increases with increase in concentration of the inhibitor and decreases with the

increase in temperature. FMHC has the ability to inhibit both cathodic and anodic reactions to the same

extent thereby acting as mixed type of inhibitor. The activation and thermodynamic parameters of corrosion

and adsorption processes were evaluated and discussed. The adsorption of FMHC on the mild steel was

found to take place through physisorption and followed Langmuir's adsorption isotherm.

e or s Mild steel, impedance, physisorption Langmuir's isotherm

PP-89

PP-90A on enient eo i ation o o i es uO atal e o i ation 4

rea tionrahi A. . Nan ini . an unatha . . etta aiah . .

Spice and Flavour Science Department,CSIR-Central Food Technological Research Institute, Mysuru 570 020

A stra t A feasible oxidation of oximes derived from aldehydes and ketones to afford carbonyl

compounds by the RuO4 catalyzed reaction is reported. In synthetic organic chemistry oximation and

deoximation are mainly adopted for the protection and deprotection of carbonyl compounds and hence

oximes are considered as carbonyl equivalents. The oximes derived from aromatic compounds such as

vanillin, p-methyl acetophenone, benzaldehyde and cyclic saturated ketone like cyclohexanone were

conveniently oxidized in a near quantitative yield in shorter duration (3 h). Ruthenium (IV) oxide was

generated by the reaction of Ru(III) chloride and NaIO4. In a typical reaction, oximes (1 equivalent) were

made to react with the mixture containing Ru(III)chloride (0.1%) and NaIO4 (1.5 equivalent) in ethyl acetate:

acetonitrile: water (3:3:1) at 0-5 ºC. These reactions are straight forward and formed exclusively the parent

carbonyl compounds. The product formation was identified by TLC and confirmed by the NMR, IR and

HRMS spectral analysis. The oximes derived from zerumbone and carvone, substrates having reactive

double bonds, were preferentially afforded double bond oxidized products and no deoximation was

observed.

91

ICET

. . Nan ini

ICET

. . Nan ini

Spice and Flavour Science Department,

ICETSpice and Flavour Science Department,

SIR-Central F

ICET

SIR-Central Food T

ICETood Technological Research Institute, Mysuru 570 020

ICET

echnological Research Institute, Mysuru 570 020ood Technological Research Institute, Mysuru 570 020ood T

ICETood Technological Research Institute, Mysuru 570 020ood T

oxidation

ICEToxidation of

ICETof oximes

ICEToximes derived

ICETderived

RuO4

ICETRuO4 catalyzed

ICETcatalyzed reaction

ICETreaction

mainly

ICET

mainly adopted

ICET

adopted for

ICETfor the

ICET

the

considered

ICET

considered as

ICET

as carbonyl

ICET

carbonyl equivalents.

ICET

equivalents.

p-methyl

ICET

p-methyl acetophenone,

ICET

acetophenone,

conveniently

ICET

conveniently

ICET

oxidized

ICET

oxidized in

ICET

in a

ICET

a near

ICET

near

generated by the reaction of Ru(III) chloride and NaIO4. ICET

generated by the reaction of Ru(III) chloride and NaIO4.

react ICET

react with ICET

with the ICET

the mixture ICET

mixture

water ICET

water (3:3:1) ICET

(3:3:1)

CA on enient eo i ation o o i es uO

CA on enient eo i ation o o i es uO

rea tion

Crea tion

. . Nan ini

C. . Nan ini . an unatha

C. an unatha

Spice and Flavour Science Department,CSpice and Flavour Science Department,echnological Research Institute, Mysuru 570 020Cechnological Research Institute, Mysuru 570 020

SLangmuir's

SLangmuir's

A on enient eo i ation o o i es uOSA on enient eo i ation o o i es uOrea tionSrea tion

. an unatha S. an unatha

-201

7temperatures

-201

7temperatures

(FMHC)

-201

7(FMHC) was

-201

7was investigated

-201

7investigated

spectroscopy

-201

7spectroscopy techniques.

-201

7techniques.

inhibitor

-201

7inhibitor and

-201

7and decreases

-201

7decreases

and

-201

7and anodic

-201

7anodic reactions

-201

7reactions

thermodynamic

-201

7thermodynamic parameters

-201

7parameters

and adsorption processes were evaluated and discussed. The adsorption of FMHC on the mild steel was

-201

7and adsorption processes were evaluated and discussed. The adsorption of FMHC on the mild steel was

Langmuir's

-201

7Langmuir's adsorption

-201

7adsorption isotherm.

-201

7isotherm.

Langmuir's -201

7Langmuir's isotherm-2

017

isotherm

A on enient eo i ation o o i es uO-201

7

A on enient eo i ation o o i es uO

nthesis hara teri ation ol eto hro i an iolo i al stu ies o no el en othia ole ase a o es

a a a aali a a esha a a hou at Ali . . A arisha .aDepartment of PG Studies and Research in Chemistry, Kuvempu University

Janna sahyadri, Shankaragatta-577451, Shimoga, Karnataka, India*Corresponding author: E-mail: [email protected]

A stra t In this present investigation, we describe the synthesis, characterization and biological evaluation

of a new series of Benzothiazole based azo dyes. The structures of the newly synthesized compounds were

characterized by various spectral techniques. The in-vitro antimicrobial activities of the target compounds

were evaluated against various bacterial and fungal strains some of the synthesized compounds were

shows good activity against bacterial as well as fungal.

e or s Benzothiazole, Antimicrobial, azo dyes.

nthesis o en o uran lin e rrole eri ati es as anti- an er a ents

eera ha ra a . Ne alur ath O. otresh

.Department of Chemistry, Karnatak University's Karnatak Science College, Dharwad-580001, Karnataka, India.

A stra t Herein, we report the synthesis of benzofuran linked pyrrole derivatives 8(a-o) using benzofuran-

3-acetic acids. The benzofuran-3-acetic acids were converted into hydrazides and cyclized to title

compounds by treating with hexan-2,5-dione. The obtained products were characterized by IR, 1H NMR,

13C NMR and mass spectral data. All the compounds were screened for anticancer activity against two

cancer cell lines viz., MDA-MB human adenocarcinoma mammary gland and A-549 human lung carcinoma.

The halogen and methoxy substitutions on benzofuran resulted as lead compounds.

e or s Anti-cancer, benzofuran, biheterocycle, coumarin, hydrazide, pyrrole

PP-91

PP-92

92

ICET

benzofuran-3-acetic

ICET

benzofuran-3-acetic

hexan-2,5-dione.

ICET

hexan-2,5-dione.

spectral

ICETspectral data.

ICETdata. All

ICETAll the

ICETthe compounds

ICETcompounds

A-MB

ICETA-MB human

ICEThuman adenocarcinoma

ICETadenocarcinoma

methoxy

ICETmethoxy substitutions

ICETsubstitutions on

ICETon benzofuran

ICETbenzofuran

Anti-cancer

ICET

Anti-cancer,

ICET

, benzofuran,

ICET

benzofuran, biheterocycle,

ICET

biheterocycle,

CDharwad-580001, Karnataka, India.

CDharwad-580001, Karnataka, India.

synthesis

Csynthesis of

Cof benzofuran

Cbenzofuran

benzofuran-3-acetic Cbenzofuran-3-acetic acids Cacids were Cwere converted Cconverted

hexan-2,5-dione. Chexan-2,5-dione. The CThe obtained Cobtained

compounds Ccompounds

Sas anti- an er a ents

Sas anti- an er a ents

eera ha ra a . Ne alur ath O

Seera ha ra a . Ne alur ath O

, Karnatak University's Karnatak Science College,

S, Karnatak University's Karnatak Science College,

Dharwad-580001, Karnataka, India.SDharwad-580001, Karnataka, India.

linked Slinked

-201

7synthesized

-201

7synthesized compounds

-201

7compounds

of

-201

7of the

-201

7the target

-201

7target compounds

-201

7compounds

synthesized

-201


-201

7compounds

nthesis o en o uran lin e rrole eri ati es

-201

7nthesis o en o uran lin e rrole eri ati es

as anti- an er a ents-201

7as anti- an er a ents

eera ha ra a . Ne alur ath O-201

7eera ha ra a . Ne alur ath O. -2

017

. otresh-201

7otresh

, Karnatak University's Karnatak Science College, -201

7

, Karnatak University's Karnatak Science College,

e tral ther al iolo i al an ole ular o in stu ies o etal o le es ontainin en i i a ole oiet

1 1 2 2an ura T rishna urth a a . o e . . ho a Nai1

oha e ha eeulla aDepartment of Chemistry, Sahyadri Science College (Auto), Shimoga, Karnataka INDIA.

bDepartment of Post graduation studies in Industrial Chemistry, jnanasahyadri, Kuvempu University, Shankaraghatta, Karnataka INDIA.

A stra t The new series of Co(II), Ni(II) and Cu(II) metal complexes with 4-{(1Z)-1-[2-(1H-benzimidazol-2-

ylmethyl)hydrazinylidene]ethyl}phenol (LB) have been synthesized. The complexes thoroughly

characterized by different physicochemical and spectral techniques such as UV-Vis, IR, NMR, and LC-Mass.

The powder XRD data indicates the crystalline state and morphology of Ni(II) and Co(II) complexes, the

thermal stability of the metal complexes as been performed. The synthesized compounds were evaluated

for their anticancer properties against three human cancer cell lines breast cancer (MCF-7) and cervical

(Hela) it was found that complexes exhibited excellent activity. In addition, the cytotoxic activity is correlated

with docking interactions with epidermal growth factor receptor EGFR; PDB code: 2A91 as cancer receptor.

The antioxidant activities of the complexes have been evaluated by using DPPH assay, among those Cu(II)

complex showed promising activity than the ligand.

e or s Benzimidazole, XRD, cytotoxicity, docking, and DPPH assay

etal o le es o 2- 1 3- en o a ol-2- l -2 3- ih ro hthala ine-1 4- ione e tral ther al ole ular o in

an iolo i al e aluation1 1 2

Na een Ara h a ishnu urth A. . ho a Nai 3 3 3a anna N an ura T hree har

1Department of PG studies in Industrial chemistry, Sir M.V Govt Science College, Bhadravathi. Karnataka (INDIA)

2Department of Post graduation studies in Industrial Chemistry, Jnana sahyadri, Kuvempu University, Shankaraghatta, Karnataka INDIA.

3Department of Chemistry, Sahyadri Science College (Auto), Shimoga, Karnataka (INDIA).Corresponding author: [email protected]

The series of Co (II), Ni (II) and Cu(II) metal complexes of 2-(1,3-benzoxazol-2-yl)-2,3-dihydrophthalazine-

1,4-dione (PB) have been synthesized. All the complexes thoroughly characterized by different physico-

chemical and spectroscopic techniques (UV-Vis, IR, NMR and ESI-Mass). The powder XRD indicates the

crystalline state and morphology of Ni (II) and Cu (II) metal complexes, the thermal stability of the metal

complexes as been performed. In the current study, the synthesized compounds were evaluated for their

antioxidant activity by using DPPH assay, Cu (II) metal complex exhibited higher antioxidant activity almost

close to the standard BHT. In addition, antioxidant activity is correlated with docking interactions of human

antioxidant enzyme receptor with the competitive inhibitor DTT (PDB: 3MNG), which showed greater

binding interactions with metal complexes. The antimicrobial studies have been carried out against different

bacterial and fungal strains and the results showed that metal complexes are more active than the ligand BT.

e or s Benzoxazole, metal complex, XRD, Antioxidant, molecular docking.

PP-93

PP-94

93

ICET

1 4- ione e tral

ICET

1 4- ione e tral an iolo i al e aluation

ICETan iolo i al e aluation

1

ICET1Na een Ara h a

ICETNa een Ara h a

ICET ishnu urth A

ICETishnu urth A

3

ICET3a anna N

ICETa anna N an ura T

ICET an ura T

1

ICET1Department of PG studies in Industrial chemistry

ICETDepartment of PG studies in Industrial chemistry

Sir M.V Govt Science College, Bhadravathi. Karnataka (INDIA)

ICET

Sir M.V Govt Science College, Bhadravathi. Karnataka (INDIA)Department of P

ICET

Department of Post graduation studies in Industrial Chemistry

ICET

ost graduation studies in Industrial ChemistryShankaraghatta, Karnataka INDIA

ICET

Shankaraghatta, Karnataka INDIADepartment of Chemistry

ICET

Department of ChemistryCorresponding author: vishnumurthy

ICET

Corresponding author: vishnumurthy

The series of Co (II), Ni (II) and Cu(II) metal complexes of 2-(1,3-benzoxazol-2-yl)-2,3-dihydrophthalazine- ICET

The series of Co (II), Ni (II) and Cu(II) metal complexes of 2-(1,3-benzoxazol-2-yl)-2,3-dihydrophthalazine-

(PB) ICET

(PB) have ICET

have been ICET

been

spectroscopic ICET

spectroscopic

Cetal o le es o 2- 1 3- en o a ol-2- l -2 3- ih ro hthala ine-

Cetal o le es o 2- 1 3- en o a ol-2- l -2 3- ih ro hthala ine-

1 4- ione e tral

C1 4- ione e tral ther al ole ular o in

C ther al ole ular o in

an iolo i al e aluationCan iolo i al e aluation

ishnu urth ACishnu urth A

Sdocking,

Sdocking, and

Sand DPPH

SDPPH

etal o le es o 2- 1 3- en o a ol-2- l -2 3- ih ro hthala ine-Setal o le es o 2- 1 3- en o a ol-2- l -2 3- ih ro hthala ine- ther al ole ular o in S ther al ole ular o in

-201

74-{(1Z)-1-[2-(1H-benzimidazol-2-

-201

74-{(1Z)-1-[2-(1H-benzimidazol-2-

o

-201

7om

-201

7mp

-201

7pl

-201

7le

-201

7ex

-201

7xe

-201

7es

-201

7s

Vis,

-201

7Vis, IR,

-201

7IR, NMR,

-201

7NMR, and

-201

7and

Ni(II)

-201

7Ni(II) and

-201

7and Co(II)

-201

7Co(II) complexes,

-201

7complexes,

synthesized

-201


-201

7compounds were

-201

7were

lines

-201

7lines breast

-201

7breast cancer

-201

7cancer (MCF

-201

7(MCF

addition,

-201

7addition, the

-201

7the cytotoxic

-201

7cytotoxic

receptor

-201

7receptor EGFR;

-201

7EGFR; PDB

-201

7PDB code:

-201

7code: 2A91

-201

72A91

evaluated

-201

7evaluated by

-201

7by using

-201

7using DPPH

-201

7DPPH

DPPH -201

7DPPH assay-2

017

assay

Aro ati h ra i e eri ati e as orrosion inhi itor or il steel in h ro hlori a i e iu -An ele tro he i al a roa h

1 1 1Preethi u ari P Pra ash hett u a A ao

1Department of chemistry, Manipal Institute of Technology, Manipal University, Manipal, 576104

A stra t The corrosion inhibition behaviour of mild steel in hydrochloric acid medium in the presence an

aromatic hydrazide derivative namely 2-(3,4,5-trimethoxybenzylidene) hydrazinecarbothioamide (TMBHC)

was investigated using potentiodynamic polarization and electrochemical impedance spectroscopic

techniques. The inhibition efficiency increased with the increase in inhibitor concentration and increased

with increase in temperatures. Polarization study revealed that the studied inhibitor acted as mixed type and

the adsorption of inhibitor molecule on the mild steel surface obeyed Langmuir's adsorption isotherm. The

kinetic and thermodynamic parameters were calculated and discussed in detail. The surface morphology of

the specimen was studied using scanning electron microscope.

e or s Mild steel, hydrochloric acid, adsorption, EIS, SEM

PP-95

94

PP-96A o es s nthesis an a raisal o their hro o eni etal ion

sensor a li ations

arthi a ari as a shitha an han han a unil

Department of chemistry, Manipal Institute of Technology, Manipal University, Karnataka

A stra t In this present era of advanced scientific research, a large number of biological processes require

the involvement of molecular recognition of ionic species, which in turn has attracted appreciable attention

towards metal ion sensing and synthetic ion receptors. Of the most thriving class of chemo sensors,

azodyes play a significant role owing to their photo-thermal stability and solubility properties. Our main

focus of this project is to synthesize new azodyes and study their chromogenic cation-sensing properties.

2-hydroxy-5-(phenyldiazenyl)benzaldehyde with substituents (-NO , -Br, -OCH ) are synthesised by 2 3

diazotization reaction of aniline and substituted aniline, i.e. -NO , -Br, -OCH with sodium nitrite and 2 3

salicylaldehyde. The resulting products are treated with aniline leading to the formation of

4-[(E)-phenyldiazenyl]-2-[(E)-(phenylimino) methylphenol and its substituted ones. The synthesised 1 13molecules are characterised by IR, H-NMR, C-NMR and Mass Spectrometry. The chromogenic cation

sensing properties of the synthesised azodyes have been studied.

e or s Azo dyes, Chemo sensor, Chromogenic cations.



advanced

ICET

advanced scientific

ICET

scientific

recognition

ICETrecognition of

ICETof ionic

ICETionic

sensing

ICETsensing and

ICETand synthetic

ICETsynthetic ion

ICETion receptors.

ICETreceptors.

significant

ICETsignificant role

ICETrole owing

ICETowing to

ICETto their

ICETtheir

is

ICET

is to

ICET

to synthesize

ICET

synthesize new

ICET

new

-5-(phenyldiazenyl)benzaldehyde

ICET


reaction

ICET

reaction of

ICET

of aniline

ICET

aniline and

ICETand

d

ICET

de

ICET

eh

ICET

hy

ICET

yd

ICET

de

ICET

e.

ICET

. T

ICET

Th

ICET

he

ICET

e r

ICET

re

ICET

es

ICET

su

ICET

ul

ICET

l

ICET

t

ICET

t

4-[(E)-phenyldiazenyl]-2-[(E)-(phenylimino) ICET

4-[(E)-phenyldiazenyl]-2-[(E)-(phenylimino)

are ICET

are characterised ICET

characterised

properties ICET

properties of ICET

of

Csensor a li ations

Csensor a li ations

arthi a ari as a shitha an han han a unil

Carthi a ari as a shitha an han han a unil

, Manipal Institute of T

C, Manipal Institute of Technology

Cechnology, Manipal Institute of Technology, Manipal Institute of T

C, Manipal Institute of Technology, Manipal Institute of T

scientific Cscientific research, Cresearch,

ionic Cionic species, Cspecies,

SA o es s nthesis an a raisal o their hro o eni etal ion

SA o es s nthesis an a raisal o their hro o eni etal ion

sensor a li ations

Ssensor a li ations

arthi a ari as a shitha an han han a unilSarthi a ari as a shitha an han han a unil

echnologySechnology

-201

7impedance

-201

7impedance

concentration

-201

7concentration and

-201

7and

inhibitor

-201

7inhibitor acted

-201

7acted as

-201

7as mixed

-201

7mixed

Langmuir's

-201

7Langmuir's adsorption

-201

7adsorption isotherm.

-201

7isotherm.

in

-201

7in detail.

-201

7detail. The

-201

7The surface

-201

7surface morphology

-201

7morphology

A o es s nthesis an a raisal o their hro o eni etal ion -201

7A o es s nthesis an a raisal o their hro o eni etal ion

sensor a li ations-201

7

sensor a li ations

PP-97tu o eso or his in the inar i tures o i luoro

u stitute hi ase ith 4-n-al lo en oi A i s

A oor a Poorni a ha a ath rini asulu a asani an Pa ithra P

Department of Chemistry, Manipal Institute of Technology, Manipal UniversityManipal – 576 104, India, [email protected]

Tel. +91-9845609002, Fax. +91-820-2571071.

A stra t A novel homologous series of hydrogen bonded liquid crystals are prepared by the non-covalent

interactions between a non- mesogenic proton acceptor and mesogenic proton donors namely 4-n-alkyloxy

benzoic acid [nOBA's for n =3, 4, 5, 7, 8, 9 and 12] moieties. Formation of the binary mixtures is confirmed

through FTIR spectroscopy. Phase characterization of the newly synthesized binary mixtures are carried out

by Polarizing Optical Microscope (POM) equipped with a hot stage. Thermal characterization is carried out

by Differential Scanning Calorimeter (DSC). The effect of fluorine substitution on the mesomorphic thermal

stability as well as the clearing temperatures of the binary mixtures are discussed in the wake of the available

data on the similar hydrogen bonded liquid crystals.

PP-98

nthesis an hro o eni ation sensin ro erties o so e ne a o es

Anoon Nishith hin a atri a hana han a unil

Department of chemistry, Manipal Institute of Technology Manipal University, Karnataka


A stra t Molecular recognition of ionic species is one of the fundamental processes in nature. Functional

materials with molecular receptors is a new direction in chemistry. In recent decades due to the factuality that

a large number of biological processes include molecular recognition of ionic species, synthetic receptors

for sensing of metal ions have attracted significant attention. Chemo sensors based on azo dyes play a vital

role due to their associated photo-thermal stability and solubility properties. This study is focussed on the

synthesis of some new azo dyes and study of their chromogenic cation sensing properties. Substituted

2-hydroxy-5-(phenyldiazenyl)benzaldehyde were synthesyzed by the diazotization reaction of aniline. The

resulting products were treated with ethyl acetoacetate and piperidine to form a series of 3-acetyl-

6[phenyldiazenyl]-2H-1-benzopyran-2-one derivatives. The synthesized compounds were characterized by

UV, IR, ¹H-NMR, ¹³C-NMR, and mass spectrometry. Chromogenic cation sensing properties of the

synthesized azo dyes were investigated.

e or s Azo dyes, Chemo sensor, Chromogenic cations

95

ICET


ICET

Department of chemistryManipal University

ICET

Manipal UniversityE


ICET-mail: [email protected]

recognition

ICETrecognition of

ICETof ionic

ICETionic species

ICETspecies

molecular

ICETmolecular receptors

ICETreceptors is

ICETis a

ICETa new

ICETnew

biological

ICET

biological processes

ICET

processes

metal

ICET

metal ions

ICET

ions have

ICET

have attracted

ICET

attracted

to

ICET

to their

ICET

their associated

ICET

associated

ICET

photo-thermal

ICET

photo-thermal

synthesis ICET

synthesis of ICET

of some ICET

some new ICET

new azo ICET

azo

-5-(phenyldiazenyl)benzaldehyde ICET


products ICET

products were ICET

were

Co so e ne a o es

Co so e ne a o es

Anoon Nishith hin a atri a hana han a unil

CAnoon Nishith hin a atri a hana han a unil

Department of chemistryCDepartment of chemistry, Manipal Institute of TC, Manipal Institute of TManipal UniversityCManipal University

-mail: [email protected]: [email protected]

Snthesis an hro o eni ation sensin ro erties

Snthesis an hro o eni ation sensin ro erties

o so e ne a o esSo so e ne a o es

Anoon Nishith hin a atri a hana han a unilSAnoon Nishith hin a atri a hana han a unil

-201

7namely

-201

7namely

binary

-201

7binary mixtures

-201

7mixtures

binary

-201

7binary mixtures

-201

7mixtures are

-201

7are carried

-201

7carried

Thermal

-201

7Thermal characterization

-201

7characterization is

-201

7is

substitution

-201

7substitution on

-201

7on the

-201

7the mesomorphic

-201

7mesomorphic

are

-201

7are discussed

-201

7discussed in

-201

7in the

-201

7the wake

-201

7wake

nthesis an hro o eni ation sensin ro erties -201

7

nthesis an hro o eni ation sensin ro erties o so e ne a o es-2

017

o so e ne a o es

PP-99esi nin an e tral hara teri ation o etal hthalo anines

An hore 3 5- ih a ro -2-na tanoi ase ol 1 3 4-o a ia ole ar l ester

a a. hi anan a . . enu o ala e Anithaa an ital ao a Department of Industrial Chemistry, Sahyadri Science College (Autonomous),

Kuvempu University, Shivamogga -577 203, Karnataka, India.b Department of chemistry, Vijayanagar Srikrishnadevaraya University, Bellary- 583 105, Karnataka, India.

*E-mail: [email protected]

A stra t Metalphthalocyanines Anchored 3, 5-dihyadroxy-2-naptanoic based poly(1,3,4-oxadiazole aryl

ester) have been efficiently synthesized and structural integrity of the peripherally ploy substituted

metallophthalocyanine complexes were elucidated by elemental analyses, FT-IR, solid state electronic

absorption spectroscopy and solid state 1H NMR spectroscopy. In addition, powdered X-ray diffraction

(XRD) and thermo gravimetric analysis (TGA) were also performed to realize crystallographic nature and

thermal stability. Further the dielectric constant (�1) and AC conductivity ( ac) of polymer

metallophthalocyanines was also studied. The variation of capacitance (Cs), loss tangent (tan ) and

impedance (Z) with frequency range of 50 to 5x106 Hz was observed at room temperature and it clearly

shows that all these complexes carousing that non-Debye type relaxation caused by hopping charges may

relevant for the dielectric responses.

PP-100nthesis an en e inhi ition stu ies o so e ou arin

eri ati es1 2 3hi a rasa hett N Anil u ar Anil u ar

1Department of chemistry, NMAM Institute of Technology, Nitte, Karkala2Department of chemistry, Manipal Institute of Technology, Manipal

3Department of Biotechnology, NMAM Institute of Technology, Nitte, KarkalaE-mail: [email protected]

A stra t Obesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth for

deaths worldwide. It also leads to diabetes, cardiovascular disorders, usculoskeletal disorders and some

types of cancer. Obesity is regarded as the output of a long-term imbalance between energy intake and

energy expenditure. Along with obesity diabetes mellitus is a metabolic disorder of glucose metabolism. The

management of blood glucose level is the hallmark in the treatment of this disease. The purpose of the

present study was to investigate the inhibitory effect of synthetic coumarin derivatives on the activities of

-amylase and lipase. This was performed using -amylase from Aspergillus niger and lipase from Fusarium

oxysporium.

e or s 7-hydroxy, 4-methyl coumarin, enzyme inhibition, -amylase and lipase.

96

ICET

nthesis an en e inhi ition stu ies o so e ou arin

ICET

nthesis an en e inhi ition stu ies o so e ou arin

1

ICET1hi a rasa hett

ICEThi a rasa hett N Anil

ICET N Anil


ICETDepartment of chemistry, NMAM Institute of T

ICET, NMAM Institute of T


ICETDepartment of chemistry

Department of Biotechnology

ICET

Department of BiotechnologyE-mail: [email protected]

ICET


Obesity

ICET

Obesity is

ICET

is a

ICET

a disorder

ICET

disorder of

ICETof

worldwide.

ICET

worldwide. It

ICET

It also

ICET

also leads

ICET

leads

of ICET

of cancer ICET

cancer. ICET

. Obesity ICET

Obesity is ICET

is

expenditure. ICET

expenditure. Along ICET

Along

of ICET

of blood ICET

blood

Cnthesis an en e inhi ition stu ies o so e ou arin Cnthesis an en e inhi ition stu ies o so e ou arin eri ati esCeri ati es

N Anil C N Anil

Snon-Debye

Snon-Debye

nthesis an en e inhi ition stu ies o so e ou arin Snthesis an en e inhi ition stu ies o so e ou arin

-201

7poly(1,3,4-oxadiazole

-201

7poly(1,3,4-oxadiazole

peripherally

-201

7peripherally ploy

-201

7ploy substituted

-201

7substituted

analyses,

-201

7analyses, F

-201

7FT

-201

7T-IR,

-201

7-IR, T-IR, T

-201

7T-IR, T solid

-201

7solid state

-201

7state

addition,

-201

7addition, powdered

-201

7powdered X

-201

7X-ray

-201

7-ray X-ray X

-201

7X-ray X

to

-201

7to realize

-201

7realize crystallographic

-201

7crystallographic

d

-201

7d A

-201

7AC

-201

7C c

-201

7co

-201

7on

-201

7nd

-201

7du

-201

7uc

-201

7ct

-201

7ti

-201

7iv

-201

7vi

-201

7it

-201

7ty

-201

7y

capacitance

-201

7capacitance (Cs),

-201

7(Cs), loss

-201

7loss

was

-201

7was observed

-201

7observed at

-201

7at room

-201

7room

type -201

7type relaxation -2

017

relaxation caused -201

7caused

PP-101li olta etri stu o 3 5- initro tolui a i an

3 5- initro hthali a i at lass ar on ele tro ea a a

alathesh Pari . . enu o ala e ouneshaDepartment of Studies in Chemistry/Industrial Chemistry,

Vijayanagara Sri Krishnadevaraya University Jnansagara Campus, Vinayakanagar, Contonment, Ballari – 583 105, Karnataka, India

A stra t We have reported the electrochemical behavior of 3,5-dinitotoluic acid and 3,5-dinitrophthalic Hacid on glassy carbon electrode at different P at various scan rates and different concentrations. In both

the cases single irreversible wave was observed due to the reduction of NO group. The effect of sweep rate, 2

Hscan rate , concentration and different P were reported. The electrode process was found to be diffusion

controlled irreversible involving adsorption. The study reveals twelve electron reduction reduction

mechanism leading to the formation of 3,5-diamintoluic acid and 3,5-diaminophthalic acid. Cataionic

micelle forming surfactant cetyle trimethylammonium bromide (CTAB) in habited the reduction process.

Effect of CTAB on EPc , iPc, diffusion co-efficient (Do) and heterogeneous forward rate constant (K0),

kinetic parameters such as D , K , were also discussed and in addition the physico-chemical parameters 0 0

like NMR, IR , UV were also reported.

e or s cyclic voltametry, 3, 5-dinitrotoluic acid, 3,5-dinitophthalic acid, glassy carbon electrode, Hphosphate buffer at different P , reduction, surfactant.

PP-102

nthesis hara teri ation an e tros o i e i en e o or ation o iso ers o 4 8- i eth l-2 6- i hen l-1 5- ih ro-s-in a ene

ussu ir Pasha Push a ati . .A shu ali

Department of Chemistry/Industrial Chemistry, Vijayanagara Sri Krishnadevaraya University Ballari 583105

A stra t The new compound, 4, 8-dimethyl-2, 6-diphenyl-1, 5-dihydro-s-indacene was prepared in

almost quantitative yield, starting from the reaction of diethyl phenyl malonate and 1, 5-dimethyl-1, 4-

dibromomethyl benzene. Various intermediates were prepared. the regioselective electron donating methyl

groups in central benzene ring of the starting material induce intramolecular regiospecific cycloeliminations

leading selectively to the 4,8-dimethyl-2,6-diphenyl-1,2,3,5,6,7-hexahydro-s-indacene-1,5-dione

(diketone), reduction of diketone gave a 4,8�dimethyl-2,6 -diphenyl-1,2,3,5,6,7 -hexahydro-s -indacene-1,5-

diol (diol), the treatment of diol with P-toluene sulphonic acid gave a titled compound all the intermediate

and final compound is obtained .The new synthesised 4npi electron delocalizing fused ring hydrocarbons,

4,8,dimethyl-2,6,diphenyl-1,5,dihydro-s-indacene and its intermediates forms the stereoisomers. Proton

and carbon NMR spectra is the evidence for the presence of isomers the chemical shift indicates a very

similar electronic structure for the two isomers. The hydrogens at sp3carbon is not same so one of the

hydrogens is on the same side where the phenyl group is and the other is more far on the other side of the 1ring, so, magnetically they are not equivalent. The diketone intermediate show the multiples in the HNMR.

97

ICET

nthesis hara teri ation an e tros o i e i en e o or ation

ICET

nthesis hara teri ation an e tros o i e i en e o or ation o iso ers o 4 8- i eth l-2 6- i hen l-1 5- ih ro-s-in a ene

ICET

o iso ers o 4 8- i eth l-2 6- i hen l-1 5- ih ro-s-in a ene

ussu ir P

ICETussu ir Pasha P

ICETasha P

Department of Chemistry/Industrial Chemistry

ICETDepartment of Chemistry/Industrial Chemistry

Vijayanagara Sri Krishnadevaraya University Ballari 583105

ICET

Vijayanagara Sri Krishnadevaraya University Ballari 583105

new

ICET

new compound,

ICET

compound, 4,

ICET4, 8-dimethyl-2,

ICET

8-dimethyl-2,

quantitative

ICET

quantitative yield,

ICET

yield, starting

ICET

starting

dibromomethyl

ICET

dibromomethyl benzene.

ICET

benzene. V

ICET

Various

ICET

arious Various V

ICET

Various V

in ICET

in central ICET

central benzene ICET

benzene ring ICET

ring

l ICET

le ICET

ec ICET

ct ICET

ti ICET

iv ICET

ve ICET

el ICET

l ICET

y ICET

y t ICET

to ICET

o

reduction ICET

reduction

Cnthesis hara teri ation an e tros o i e i en e o or ation Cnthesis hara teri ation an e tros o i e i en e o or ation o iso ers o 4 8- i eth l-2 6- i hen l-1 5- ih ro-s-in a eneCo iso ers o 4 8- i eth l-2 6- i hen l-1 5- ih ro-s-in a ene

Sacid,

Sacid, 3,5-dinitophthalic

S3,5-dinitophthalic

surfactant.

Ssurfactant. -2

017

concentrations.

-201

7concentrations.

group.

-201

7group. The

-201

7The effect

-201

7effect of

-201

7of sweep

-201

7sweep

process

-201

7process was

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7was found

-201

7found to

-201

7to be

-201

7be

twelve

-201

7twelve electron

-201

7electron reduction

-201

7reduction

3,5-diaminophthalic

-201

73,5-diaminophthalic

(CT

-201

7(CTAB)

-201

7AB) (CTAB) (CT

-201

7(CTAB) (CT in

-201

7in habited

-201

7habited the

-201

7the

heterogeneous

-201

7heterogeneous forward

-201

7forward

and

-201

7and in

-201

7in addition

-201

7addition the

-201

7the physico-chemical

-201

7physico-chemical

3,5-dinitophthalic -201

73,5-dinitophthalic

PP-103Anti-neo lasti a ti it o ne l s nthesi e nano- arti les

1 1 2 eena. . . hi a rasa A. . ru ani hi1Department of Chemistry, Vijayanagara Sri Krishna Devaraya University, Bellary.

2Bapuji Pharmacy College, Davangere, Karnataka.

A stra t Cancer is one of the principal causes of mortality worldwide and represents a serious health

problem. Nano-particles have received much attention in present scenario due to their use in cancer

therapy. Previous studies have reported that many nanoparticles exhibit antioxidant and possess anti-fertility

activity. TiO2 which has a very wealthy data regarding cyto-toxicity, based on clinical efficacy the present

study was subjected to novel synthesis of nano-crystalline powders of un doped TiO2 and also the one

doped with Pt, Pd and both Pt/Pd. The synthesized nano-crystalline oxides have been characterized by XRD,

SEM, UV, IR and DLS. The anticancer activity of synthesized naoparticles was tested against Ehrlich's

Ascites Carcinoma (EAC) induced tumors in Swiss mice. Treatment efficiency was assessed in terms of

different analogues effects on the tumor volumes of the tumor beard mice relative to the control group. The

two parameters of Specific tumor growth delay (SGD) and percentage of life span (ILS%) was calculated. the

results of present study have revealed that the nanoparticles showed significant antitumor activity. The

observed anticancer activity of analogues was dose dependent. There was a significant increase in

percentage of life span i.e., 52.38% to 57.14% in treated mice. Thus synthesized nanoparticles possess

significant anticancer activity against EAC-cells.

e or s Nano-particle, EAC, SGD, ILS, Tio2

PP-104A a ile an ra ti le one- ot s nthesis o

2- eth lselen l eth l en oi a i 1 2i ara Puthran an o a Poo ar

1Sequent Scientific Ltd., Mangalore-5750112Department of chemistry, Mangalore University, Mangalore-574199

A stra t A simple and efficient process was developed for synthesis of 2-[(methylselenyl)methyl]benzoic

acid. 2-Benzofuran-1(3H)-one was converted into 2-[(methylselenyl)methyl]benzoic acid in presence of

dimethyl diselenide , sodium borohydride and sodium hyroxide in moderate to good yield and purity.

98

ICET

A a ile an ra ti le one- ot s nthesis o

ICET

A a ile an ra ti le one- ot s nthesis o 2- eth lselen l eth l en oi a i

ICET2- eth lselen l eth l en oi a i

i ara P

ICETi ara Puthran

ICETuthran

1

ICET1Sequent Scientific Ltd., Mangalore-575011

ICETSequent Scientific Ltd., Mangalore-575011


ICET


ICET

simple

ICET

simple and

ICET

and efficient

ICET

efficient process

ICETprocess

2-Benzofuran-1(3H)-one

ICET

2-Benzofuran-1(3H)-one was

ICET

was

dimethyl

ICET

dimethyl diselenide

ICET

diselenide ,

ICET

, sodium

ICET

sodium

Cio2

Cio2

A a ile an ra ti le one- ot s nthesis o CA a ile an ra ti le one- ot s nthesis o 2- eth lselen l eth l en oi a i C2- eth lselen l eth l en oi a i

Streated

Streated mice.

Smice. -2

017

clinical

-201

7clinical efficacy

-201

7efficacy

doped

-201

7doped T

-201

7TiO2

-201

7iO2 and

-201

7and also

-201

7also

have

-201

7have been

-201

7been characterized

-201

7characterized

naoparticles

-201

7naoparticles was

-201

7was tested

-201

7tested against

-201

7against

efficiency

-201

7efficiency was

-201

7was assessed

-201

7assessed

beard

-201

7beard mice

-201

7mice relative

-201

7relative to

-201

7to the

-201

7the

percentage

-201

7percentage of

-201

7of life

-201

7life span

-201

7span (ILS%)

-201

7(ILS%)

nanoparticles

-201

7nanoparticles showed

-201

7showed significant

-201

7significant

dependent. -201

7dependent. There -2

017

There

mice. -201

7mice. Thus -2

017

Thus synthesized -201

7synthesized

PP-105

o ellin o ea A sor tion ro a ueous solutions oir ith an eanut shell usin es onse ur a e etho olo

hu la ha ana o a Patil an eena u ara A i

P.G Department of Environmental Engineering, Civil Engineering DepartmentBapuji Institute of Engineering and Technology, Davanagere 577004, Karnataka, INDIA

E-mail: *[email protected]

A stra t The present study is aimed at the adsorption of Lead (II) onto the low cost adsorbents such as coir

pith and peanut shell. The optimization studies were carried out using Response Surface Methodology (RSM).

The roles of variable factors on adsorption viz., initial concentration of Lead (Pb), concentration of adsorbate

and agitation time were studied. A total of 15 runs were carried out employing the detailed conditions designed

by RSM based on Box-Behnken Design. Contour plots and surface plots were analysed to know interactions

between variables. At the lowest concentration (10ppm) of adsorbate, 99.06% (predicted102.75%) was

absorbed by coir pith and 96.27 %( predicted 91.0625%) by peanut shell. At maximum concentration of

(100ppm) adsorbate 75.51 % (predicted 81.403%) was absorbed by coir pith and 60.73 % (predicted

65.9375%) by peanut shell. The maximum adsorption of Pb was observed when the initial concentration of

lead was 10ppm, adsorbate dosage of 1gm and agitation time of 13 hours. A maximum adsorption on

groundnut shell was observed when the initial concentration of Pb 10ppm, concentration of adsorbate 0.2gm

and agitation time 13 hours. It was concluded that coir pith had a good ability to adsorb Pb compared to peanut

shell. Response surface methodology seems to be ideal tool in predicting the efficacy of Pb adsorption by the

tested agro waste from the solutions.

e or s Lead (Pb), Adsorption, response surface methodology, low cost adsorbents.

PP-106reenin o a teria ith i ol ti a ti it ro

oil or n ustrial serun a a a han ra urt an i ashree

Department of Biotechnology, Manipal Institute of Technology, Manipal*Corresponding author E-mail: [email protected]

Lipases (EC 3.1.1.3) belong to the class of hydrolases which are specific to carboxylic ester bonds. The

physiologic role of lipases is to hydrolyze triglycerides into diglycerides, monoglycerides, fatty acids and

glycerol. These enzymes are widely distributed in the animal kingdom and plant kingdoms, as well as in molds

and bacteria. Lipases find extensive applications in the processing of oils and fats, food, synthesis of fine

chemicals and pharmaceuticals, paper and cosmetic industry and also as an additive in household

detergents. Large number of different lipases have been identified and commercialized. The demand of the

industries for novel sources of lipases with diverse catalytic features promotes the isolation and screening of

new lipolytic microbial strains. Herein, in this study we are focusing on obtaining the lipolytic bacterial strains

from soil contaminated with oil. Soil samples were collected from dairy area as well as oil refinery area. Soil

sample was serially diluted in 0.9% saline and plated on Tributyrin agar medium (TBA). Extracellular Lipolytic

activity of bacteria on TBA plates expressed as a zone of hydrolysis (Halo zone) around microbial colonies.

Lipolytic colonies were isolated and their Lipolytic activity was further confirmed by secondary screening in

Shake flask culture method Tributyrin broth. Supernatant was collected and analyzed qualitatively and

quantitatively for the presence of lipases. Activity of lipases is estimated Spectrophotometric method by

employing pNPP assay. The isolates giving maximum production will be identified and various parameters of

the enzyme will be analyzed.

e or s Lipases; Lipolytic organisms; Tributyrin Agar Medium.

99

ICET

reenin o a teria ith i ol ti a ti it ro

ICET

reenin o a teria ith i ol ti a ti it ro oil or n ustrial se

ICEToil or n ustrial se

run a

ICETrun a a a han ra urt an i ashree

ICET a a han ra urt an i ashree

Department of Biotechnology

ICETDepartment of Biotechnology

*Corresponding author E-mail: [email protected]

ICET

*Corresponding author E-mail: [email protected]

3.1.1.3)

ICET

3.1.1.3) belong

ICET

belong to

ICET

to the

ICET

the

physiologic

ICET

physiologic role

ICET

role of

ICET

of lipases

ICET

lipases is

ICET

is to

ICET

to

glycerol.

ICET

glycerol. These

ICET

These enzymes

ICET

enzymes are

ICET

are widely

ICET

widely

bacteria. ICET

bacteria. Lipases ICET

Lipases find ICET

find

and ICET

and pharmaceuticals, ICET

pharmaceuticals,

Large ICET

Large number ICET

number

Cresponse

Cresponse surface

Csurface methodology

Cmethodology

reenin o a teria ith i ol ti a ti it ro Creenin o a teria ith i ol ti a ti it ro oil or n ustrial seCoil or n ustrial se

Sconcentration

Sconcentration

coir

Scoir pith

Spith had

Shad

be

Sbe ideal

Sideal tool

Stool in

Sin predicting

Spredicting

methodologySmethodology

-201

7Methodology

-201

7Methodology

concentration

-201

7concentration

detailed

-201

7detailed conditions

-201

7conditions

analysed

-201

7analysed to

-201

7to know

-201

7know interactions

-201

7interactions

99.06%

-201

799.06% (predicted102.75%)

-201

7(predicted102.75%)

shell.

-201

7shell. At

-201

7At maximum

-201

7maximum

absorbed

-201

7absorbed by

-201

7by coir

-201

7coir pith

-201

7pith and

-201

7and

was

-201

7was observed

-201

7observed when

-201

7when the

-201

7the

agitation

-201

7agitation time

-201

7time of

-201

7of 13

-201

713 hours.

-201

7hours. A

-201

7A

concentration -201

7concentration of -2

017

of Pb -201

7Pb 10ppm, -2

017

10ppm, concentration -201

7concentration

a -201

7a good -2

017

good ability -201

7ability

predicting -201

7

predicting

ICETCS-2017

e art ent o he istr MIT, Manipal University, Manipal

Welcomes the Delegates of nternational on eren e on er in Tren s in he i al ien es

T -2017

enue A 2 ir e inar all

Sponsors

100

ICETCS-2017

e art ent o he istr MIT, Manipal University, Manipal

Welcomes the Delegates of nternational on eren e on er in Tren s in he i al ien es

T -2017

enue A 2 ir e inar all

Sponsors

ur a a ui ent u liers

ahalasa a en

A N A P t t

P t t

ri i i ina a a A en ies

101

he i ol A en ies

manipal institute of technology 2017 - e... · manipal institute of technology manipal 576104,...

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