mannatech story book

A Company of DestinyMannatech

2 3Timeline

Glyconutritionals Through the Ages

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended

to diagnose, treat, cure or prevent any disease.

340 B.C.Alexander the Great carries aloe vera plants with him for soldiers wounded in war.

1906Erythropoietin (a glycoprotein hormone that controls the formation of red blood cells) is discovered.

Since the beginning of recorded time, history has validated the importance of the amazing aloe vera plant.

1983Dr. Bill McAnalley discovers first biologically active polysaccharide from aloe vera gel (Manapol® and acemannan). More than 150 patents are granted worldwide on the stabilization and uses of this discovery.

1984Hydrogel with polysaccharides from aloe vera gel (Carrisyn® Hydrogel Wound Dressing) goes on the market.

1990BioTechnology magazine publishes article “Capitalizing on Carbohydrates.” Carbohydrates are identified as essential for immune function. Multinational chemical and pharmaceutical concerns identify carbohydrates as forming the next wave of drug development.

1992Acemannan is approved by the USDA for use as a vaccine adjuvant in chickens and licensed to Solvay Animal Health, Inc., the world’s largest manufacturer of veterinary vaccines.

1994Mannatech negotiates exclusive distribution rights to Manapol and launches company with nutrition industry’s first stabilized aloe vera gel dietary supplement.

1996Harper’s Biochemistry lists the eight sugars found in glycoproteins.

“Like valleys they spread out, like gardens beside a river, like aloes planted by the Lord, like cedars beside the waters.”Numbers 24:6

Mannatech’s Discovery of Glyconutrients has Helped Pioneer the Exciting New Field of Nutritional Glycobiology.

1998Study by Berger, et al., in Metabolism showed that galactose and mannose were directly incorporated into human glycoproteins without first being converted into glucose. Authors concluded that specific dietary sugars could represent a new class of nutrients.

2002(July) Scientific American article, “Sweet Medicine,” reports on pharma’s big new strategy for making better drugs from sugars.

2002(October) New Scientist magazine article, “Sugar Rush,” emphasizes glycobiology as the basis of understanding immunology, neurology and developmental biology.

2012National Academy of Sciences publishes “Transforming Glycoscience,” a roadmap for the integration of glycoscience as a significant part of higher-education curriculae within the next decade.

2200 B.C.Aloe, considered a divine plant in Nippur (Mesopotamia), is used for intestinal health.

1953Atomic Energy Commission scientists (Lushbaugh and Hale) demonstrate for the first time the ability of topical fresh aloe vera gel to protect animals’ skin.

1988The term “glycobiology” appears in the Oxford English Dictionary to recognize the merging of the disciplines of carbohydrate chemistry and biochemistry.

1990Journal of Glycobiology launched by Oxford University Press. Glycobiology is the study of the structure, biosynthesis and biology of saccharides (sugar chains, or glycans) that are widely distributed in nature.

1991Injectable polysaccharide from aloe vera gel (Acemannan Immunostimulant™) is approved by the USDA for use in cats and dogs.

1993Injectable acemannan rejected by the FDA as a drug for humans (no LD50). —Dr. Bill McAnalley, A Story of Discovery (2010).

1995Nature magazine article states cell surface sugars are necessary for recognition and immune function.

1995Dr. McAnalley joins Mannatech with focus on new field of carbohydrate technologies.

1996Mannatech files

patents on the world’s first composition of glyconutrients

and introduces Ambrotose® complex.

1998–2002As dietary sugars begin to gain acceptance as a “new class of nutrients,” Mannatech is issued more than 50 patents worldwide for technology related to Ambrotose complex.

2001Scripps Institute awarded $34 million from NIH to study glycobiology.

2002–2010 Ambrotose complex approved claims expand to include improved memory, cognition and visual discrimination as well as positive prebiotic effects.*

2011Definitive proof! Dr. Azita Alavi and colleagues publish study in the European Journal of Clinical Nutrition showing for the first time that the oral intake of

Ambrotose powder can have a significant impact on the glycosylation status of serum glycoproteins with no adverse effects.

4 The Story 5

The Gift of Provision

Amazing, Disruptive DiscoveriesIn 1996, Mannatech’s first Chief Science Officer, Bill McAnalley, PhD, made the discovery of a whole new category of plant-based nutrients called glyconutrients. Mannatech formulated the world’s first glyconutrient product, called Ambrotose® complex. Though this pioneering discovery was at first questioned, even ridiculed, by the traditional scientific community, technology supporting it has since received more than 50 worldwide patents, and it’s now revered as science’s next frontier. Ambrotose complex, formulated with the Manapol® aloe vera extract, became Mannatech’s foundational solution for proper cell-to-cell communication and immune system support.

Real Food Technology® SolutionsMannatech’s current CEO and Chief Science Officer, Robert Sinnott, MNS, PhD, extended Mannatech’s proprietary product base through the formulation of PhytoMatrix® caplets, the industry’s first vitamin and mineral product produced from natural and plant-sourced ingredients at standardized, nutritionally effective levels. This approach quickly led to the development of many new, unique products based on Real Food Technology solutions. In 2012, Dr. Sinnott blended Mannatech’s proprietary glyconutrient complex, its proprietary antioxidant composition and its proprietary real-food vitamin/mineral formulation into a whole-food base. This new product was named NutriVerus™ powder, and it became a complete Real Food Technology solution for global health.

A Desire to Make a DifferenceIn 1994, Mannatech founder Sam Caster felt called into the marketplace to launch a “Company of Provision” that would impact the lives of people in all the nations of the world. This company was destined to become a new vehicle for addressing the growing epidemic of malnourishment and its impact on the lives of billions of people, including the world’s most vulnerable children. It would require a disruptive new discovery in nutritional science combined with a revolutionary new business strategy in order to create a sustainable solution.

The Story Behind Mannatech

Sam Caster Founder of Mannatech

Enjoy the full story behind the beginning of Mannatech in the video, Destiny Unfolding.

http://bit.ly/18cLCFK

6 Mission and Vision 7

O u r M i s s i o n a n d V i s i o n

Our mission is to fight global malnutrition by nourishing the world with Real Food Technology®

supplementation while empowering and rewarding the lives of those who champion our cause.

Our vision is to impact the global epidemic of childhood malnutrition by linking five million

consumers of Real Food Technology supplementation with five million children in need.

A World-Changing ApproachAs of mid 2013, Mannatech operates in 24 countries around the world. The

company adopted the dynamic business model of social entrepreneurship to link its international product sales directly to the needs of the world’s most at-risk

children. Through its MISSION 5 MILLIONSM movement, Mannatech empowers caring individuals all around the world to join the fight against childhood malnutrition

by simply choosing to nourish themselves with advanced nutrition sourced from real foods. At the same time, Mannatech offers an unprecedented, purpose-driven business opportunity for those who choose to champion this cause.

Find out how you can join in the fight against global malnutrition. Visit Mannatech.com today.

Three to five million children under the age of 5 die every year

from the devastating effects of malnutrition.1 That means every

six seconds a child dies from malnutrition. That’s 14,000 a day.

The facts are heartbreaking. Staggering. But not unbeatable,

thanks to people like you. 1”Progress for Children: A Report Card

on Nutrition” UNICEF, May 2006

8 The Changing Face 9The Problem

What Has Gone Wrong?The Changing Faceof Malnutrition

We used to think malnourishment was a problem that existed on the other side of the world. Now, it’s a problem

that often exists just on the other side of the table.

“Malnutrition is a phenomenon that touches the lives of 55 million children at any given moment.”UNICEF“Up to one-half of all childhood deaths in the world are linked to malnutrition.”New York Times“Five million children under the age of five die each year in developing countries from malnutrition.”UNICEF

“Poor health conditions linked directly to poor nutrition have become the number one cause of disability and death in America.”Center for Science in the Public Interest“Approximately 215 million Americans now live daily with diet-related health concerns.”“Nutrition Policy” Center for Science in the Public Interest

“Nearly the entire U.S. population fails to eat a diet in line with the Dietary Guidelines for Americans.”The Journal of Nutrition, 2010

Today, malnourishment has become a global epidemic. The New York Times calls it the “New Hidden Hunger.”

ST

RE

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TO

XIC

STA

RV

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l Nearly the entire U.S. population fails to eat a diet in line with the dietary guidelines for Americans.1

l 90% of all the money Americans spend on food is used to buy processed food.2

1Krebs-Smith, S.M., Guenther, P.M., Subar, A.F., et al. Americans do not meet federal dietary recommendations. J Nutr 2010; 140(10): 1832-8.2Schlosser E. Fast Food Nation: The Dark Side of the All-American Meal. Perennial/ Harper Collins: 2001.

Many of us are not consuming enough essential nutrients!

l Over 75,000 synthetic chemicals introduced since 1980l Numerous pollutants common in our air and waterl Artifical sweeteners, colorings and preservatives in our foodsl Household cleaners, pesticides and other chemicals

We live in a toxic environment!

We are stressed! Stress produces free radicals that attack and destroy healthy cells.l Emotional stressl Excessive exercisel Smoking (including second-hand)l Excessive alcohol consumptionl Use of pharmaceuticalsl Food preservatives

Classic Face

In developing countries, the problem is consuming too little of the right kind of food.

New Face

In industrialized countries, the problem has become consuming too much of the wrong kind of food.

10 Industry’s Solution 11

Industry’s “Solution” 1 Industry’s “Solution” 2Industry saw an opportunity in our problems. Synthetically made “nutritional” alternatives

Industry’s “solution” to the loss of essential nutrients in our modern diets was the creation of synthetically made alternative nutrients. It was cheaper and more profitable to synthesize vitamins and minerals than to extract them in their natural form, from whole foods.

Every so-called “solution” has typically presented more problems.

And while the “solutions” continue to increase, our overall health continues to decline.

+ + =Genetically Modified Seeds Bigger Livestock Pesticides Big Profits

But instead, industry has radically “changed” our food over the last 50 years.

Industry set out to “improve” food.In the mid-1900s, commercial farming found new ways to grow food faster and bigger.

Then, industry focused on reinventing food by combining highly processed food ingredients with chemically made sweeteners, colorings, flavorings and preservatives. Processed food is so poor in nutritional value that one expert refers to them as “edible food-like substances.”1

1Pollan M. In Defense of Food. New York, New York: The Penguin Press, 2008.

• Synthetic vitamins are chemically produced from petroleum and coal tar derivatives, not food.

• It’s estimated that over 95% of all vitamins sold are synthetically made.1

1www.organicconsumers.org/articles/article_3697.cfm

2Ensley BD, Elless MP, Blaylock MJ, Huang JW. Hydroponic cultivation of metal-accumulating plants as a source of mineral nutrient supplements. Metal Ions in Biology and Medicine 2000;531–3.

“Minerals are generally recovered by mining ores or from chemical processes. Preliminary tests have shown that minerals contained in [many of ] the most popular brands of multivitamins may not dissolve (they are not soluble) in the stomach or small intestine. They may pass through the body without being absorbed.”2

A Quick Guide for

Evaluating Vitamin and

Mineral Supplements

Synthetically Made

Synthetic vitamins are produced chemically in a

laboratory and may be made from petroleum or

coal tar; they’re not in a food form.

Because they are less expensive, most

minerals used for supplementation are

mined from the ground or manufactured

from chemical processes.

Tests have shown that these minerals do not

dissolve well (they are not soluble) in either the

stomach or small intestine.

Plant-Sourced

Naturally sourced vitamins are extracted from foods or

plants or are cultured in yeast.

Plants use multiple processes to accumulate

minerals from the soil, predigest them and then

bond them into a food matrix. Minerals from

plants are, therefore, more soluble.

Research suggests that naturally sourced

vitamins are easier to absorb and retain than

synthetically made vitamins.

How Real Is Your Vitamin?

* These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure or prevent any disease.

Our PhytoMatrix®

caplets deliver real

food-sourced nutrients!

To achieve standardized levels of vitamin and

mineral ingredients, there are only two sources:

Approximately 150 million consumers in North America now take a vitamin/mineral

supplement daily1. But most people don’t even know the source, quality or efficacy of the

products they take. Mannatech believes that the best vitamin and mineral supplementation

should include:

•Naturally sourced vitamins with standardized and properly labeled amounts

•Plant-sourced minerals at standardized and properly labeled amounts

Do You Know

Where Your

Multivitamin

Comes From?

1Source Datamonitor: Dietary Supplements Market Trends & Opportunities 4/29/09 (Dietary Supplement Market USA)

How Real Is Your Vitamin? Find out with this tear sheet at http://bit.ly/ZC8v0v

12 Ancient Wisdom 13

Ancient WisdomWhat did they tell us?

“Everything man needs to sustain good health is provided by God in nature. The job of science is to find it.”

Paracelsus

The Design of Life: “I have given you every seed-bearing plant throughout the earth and all of the fruit trees for your food.”

Genesis 1:29

Pietro Longhi. The Apothecary—Aloe vera was a common tool in doctors' offices in the mid 18th century.

Paracelsus and Hippocrates, considered to be the fathers of pharmacology and medicine, respectively, believed that having good health was dependent upon proper nutrition. Over the centuries, technologies have evolved in both food and medicine, but this principle remains as true today as it was then. New research is showing us how the human body functions at the cellular level and how nutrients in their real-food form support these critical functions. Science is now bringing us full circle to the very foundations of health and ancient wisdom.

14 Modern Science 15

Modern ScienceMannatech accepted the challenge.

Mannatech used science to pioneer Real Food Technology® solutions.

Robert A. Sinnott, MNS, PhDCEO and Chief Science Officer

• Oversees the overall development and R&D management of Mannatech’s Real Food Technology products

• Earned Bachelor’s Degree in Biological Sciences, a Master of Natural Sciences Degree and a PhD from 1987–1995, all from Arizona State University

• Focused on plant medicinal chemistry and plant biotechnology in graduate training

• Instrumental in establishing the science branch of a nonprofit educational institution for training economically disadvantaged students in science-based careers

• Joined Mannatech in 2005

• Instrumental in the creation of Mannatech’s Real Food Technology approach

Thanks to its dedication to food-based research and development, Mannatech has become a leader in the Real Food Revolution.• Mannatech has invested tens of millions of dollars in research, development and validation.

• Working from Mannatech’s in-house laboratories, the company’s scientists and product development specialists actively explore new technologies for sourcing and formulating real-food solutions for consumer health and nutrition.

• The company’s Research Group collaborates with major universities and research firms around the world to conduct clinical trials and studies on our products and ingredients.

Visit MannatechScience.org for full details.

16 Sweet Language of Life 17The Discovery

Sweet Language of Life The Missing Link

Bill McAnalley's A Story of Discovery - Ambrotose: http://bit.ly/11DgiyU

“Almost without exception, whenever two or more living cells interact in a specific way, cell-surface carbohydrates will be involved.”Hodgson J., Capitalizing on Carbohydrates, 1991.

“Indeed, cell-surface glycosolation (i.e., the process by which cells create and display their sugar structures) is as important to understanding life as is the genetic code.” Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012.

Nourish Me

Repair Me

Destroy Me

Protect Me

Regulate Me

IMMUNE CELL

Cell-surface sugar structures called glycoproteins are necessary for the proper recognition and functioning of most of our cells. Immune cells read the cell-surface sugar structures on other cells to determine if they are healthy, need repair or need to be destroyed.

Missing Sugars = Altered MessageOur cells need sugars to communicate all their needs.

Missing Sugars Can Spell TroubleRemoving one sugar [from their cell-surface structures] turns protective antibodies (repair cells) into attackers. The research shows that the mere destructive autoimmune functions appear to be lacking antibodies associated with this (sugar).Rockefeller University, July 4, 2007

When bad cells go undetected, as in degenerative type functions, research has shown that sugars are missing from their glycoprotein structures. Capitalizing on Carbohydrates, 1991

The Missing LinkOf the 200 that naturally occur in nature, our cells use eight of these sugars like letters of an alphabet to create cellular words. The potential information content of these sugar structures vastly exceeds that of any class of macromolecules.1

“Every living cell on the planet is covered with a dense and complex array of sugar molecules. Every molecule, cell or organism that interacts with a cell must do so through these cell-surface sugar structures.”1

1Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012.

What are Glycans?Glycans—also known as carbohydrates, saccharides, or simply as sugars—are molecules made up of combinations of different sugar units, such as glucose. These units can link together to form complex, three-dimensional structures.

18 Glycoscience Validation 19Self-Evidence

Glycoscience: A Road map for the FutureSelf-Evident

“Every molecule, cell or organism that interacts with a cell must do so through these cell-surface sugar structures.”1

In 2012, a report titled Transforming Glycoscience: a Roadmap for the Future conducted by the National Academy of Sciences offered bold support for the function and importance of glycans (or glyconutrients).


Dr. John Rollins, a former award-winning U.S. Trademark and Patent Office official, upon his introduction to glyconutrients, said, “In the past 23 years ... our group at the U.S. Patent Office had the opportunity to review the best technology presented by the world’s best scientists. There have been many significant discoveries, but one stands head and shoulders above the rest: the discovery of a new category of vital nutrients called glyconutrients.”

To review the full report entitled: Transforming GlycoScience: A Roadmap for the Future

go to www.nap.edu and search “glyco.”

Integrating glycoscience into relevant disciplines in high school, undergraduate, and graduate education, and developing curricula and standardized testing for science competency would increase public as well as professional awareness.1


Roadmap Goals:l Within five years, integrate glycoscience as a significant part of the science

curriculum, including both lecture materials and hands-on experiments or activities.l Within 10 years, integrate and teach glycoscience at every level for which it is

relevant to understanding the scientific content. Competency in glycoscience could also be included in all standardized testing wherever relevant (for example, as part of the SAT and GRE Subject Tests, MCAT, and Medical Board Exams).

20 Validation 21Awards & Recognition

Awards & RecognitionGlycoNutrient Validation

March 14, 2006 Mannatech was the 29th fastest-growing public company in the Dallas/Fort Worth Metroplex, according to the Dallas Business Journal.

January 31, 2007 Mannatech received first- and second-place awards for basic science research indicating bacteria from the human digestive tract can metabolize the complex carbohydrates in the company’s glyconutritional supplements.

May 30, 2007 Mannatech was recognized by BusinessWeek as the 12th-best “Hot Growth” small company in America and as the 4th best in average return on capital over three years.

March 14, 2009 Chief Science Officer and Senior Vice President Robert Sinnott, MNS, PhD, was selected as the vice chairman of the Senior Scientific Advisory Council (SSAC) for the Council for Responsible Nutrition (CRN).

November 24, 2009 Mannatech’s educational website, MannatechScience.org, received a Web Health Merit Award for its accuracy, success in reaching its targeted audience and overall quality.

June 2011 CEO and Chief Science Officer Dr. Rob Sinnott featured in Natural Products Insider magazine article, “Aloe veritas.”

April 2012 Mannatech presents new study at the 10th Jenner Glycobiology and Medicine Symposium in the Netherlands.

July 2012 Mannatech presents product research at the 9th Annual International Society of Sports Nutrition Conference.

April 2013 Dr. Sinnott featured in Nutraceuticals World magazine article, “Open Innovation in Nutraceuticals & Functional Foods.”

We do all that we can to earn the trust consumers place in us every time they use a Mannatech product.

We hold more than 50 patents in 30 countries for the technology relating to our Ambrotose complex glyconutrient formulation. And our patent positions have been repeatedly reaffirmed in court, most recently in July 2010, when Mannatech won judgments against seven companies found to be manufacturing and marketing products that infringed on our patented glyconutrient technology.

Patents

Recent Glyconutrient Studies October 2012 University of Ghent scientists publish Ambrotose product prebiotic study in the Antoine van Leeuwenhoek Journal of Microbiology.

February 2012 Review of effects of polysaccharides on brain function is published, Mechanisms that might explain the cognitive benefits of glyconutrients and other polysaccharides are explored.

September 2011 Study shows Mannatech's Ambrotose complex improves well-being in healthy adults (titled Perceived changes in well-being following polysaccharide intake in middle-aged adults).

Quality and StandardsMannatech is committed to meeting customer, regulatory and industry standards by manufacturing products of the highest quality and value. Our suppliers conduct statistical sampling then follow it with inspection and testing. No product is ever shipped from Mannatech without the highest level of assurance that it meets our quality standards.

Current Good Manufacturing PracticesAs a global innovator, we adhere to industry-wide current Good Manufacturing Practices (cGMPs) established by various U.S. and international regulatory agencies. You can rest assured that our products are safe, effective and precisely labeled.

NSF Certification—Third-Party Mark of ExcellenceA growing number of our health products have been Certified by NSF International, an independent, third-party organization that helps ensure that supplements and ingredients are labeled accurately and contain no adulterants or contaminants.

100% Satisfaction GuaranteeYou can trust the science and quality behind our products. We’re so confident you’ll love our products that we offer a six-month Satisfaction Guarantee.††Mannatech guarantees your full satisfaction. If not completely satisfied, contact Customer Care and return the product within 180 days for a full refund. See Mannatech.com for details.

CERTIFIED

PROD

UCED

WITH SOLAR ENERGY

To see the full collection of studies and

published research, visit MannatechScience.org.

22 System Support 23The Role of Nutrients

A Common-Sense Appr oach to Optimal HealthThe Role of Nutrients

Completing the Circle of CareConsider for a minute your body as an automobile. Daily support and maintenance is required or breakdowns occur.l The modern car is designed to run on certain raw materials.l It requires routine maintenance.l It will usually last about 100,000 miles or so.The car must have fuel in the tank, oil in the engine, water in the radiator, air in the tires and, of course, a driver behind the wheel.The car also must be maintained by changing the oil and filling the gas tank.There are numerous things that may improve its performance or looks, but these components are mandatory for it to start and run. If any of the basic components are missing, or the car isn’t maintained properly, it’s not going to travel very far without breaking down. And a shiny new paint job or fresh tires won’t help if the basics are not met.

GAS

OIL

WATER

AIR

DRIVER

The same concept can be applied to understanding the human body.l Our bodies were designed to run on specific raw materials.l They require routine maintenance.l And they are designed to last about 85 years or so.Countless things may enhance how we look or feel, but nutrients are essential. Unless we provide our bodies with these basic essentials and perform the necessary maintenance, it is very difficult to sustain good health.

Nourish Me

Repair Me

Destroy Me

Protect Me

Regulate Me

IMMUNE CELL

It All Starts with the Cells

A variety of food-based nutrients is required to support healthy cells.

Healthy cells are necessary to support healthy glands, organs, tissues, bones,

fluids, blood and skin.

Healthy cells = Healthy tissue

Healthy tissue = Healthy organs

Healthy organs = Healthy systems

Healthy systems = Healthy bodies

BodySystemsOrgansTissueCells

For optimal wellness, your body needs ongoing maintenance in such areas as:

Cellular Support – Communication – Protection – Nourishment

System Support – Endocrine – Cardiovascular – Digestive

Body Fitness – Sustainable Fat Loss – Performance – Recovery

Cellular Communication Ambrotose® Complexand Advanced Ambrotose®

24 Cellular Communication 25Ambrotose

The Science of GlyconutrientsResearch published in the European Journal of Clinical Nutrition revealed for the first time in the scientific community that: • The ingestion of a standardized blend of plant poly-

saccharides (Ambrotose powder) can induce significant changes in blood glycoprotein structures.

• And there were no reported adverse events.11Alavi, A., Fraser O, Tarelli E, et al. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation profile of serum in healthy subjects. Eur J Clin Nutr 2008; 65: 648–56

The Old TheoryScientists once believed that it was not possible to influence the body’s production of cell-surface sugar structures through dietary intervention.

The New Reality

These complex sugars are usually referred to as glycans. Glycans are one of the four major classes of macromolecules—nucleic acids, proteins, and lipids being the other three—that are essential for life and are involved in every aspect of biology, medicine, and a number of practical applications. These other three classes often incorporate or rely on glycans for their activity.1Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012.

Missing Sugars = Altered MessageOur cells need sugars to communicate all their needs.

Glyconutrients

Ambrotose Productsl Support cellular communication*†

l Improve cognitive function*†

l Improve memory, concentration and attentiveness*†

l Improve mood and decrease irritability*†

l Support immune system function*†

l Support digestive system health*†

The first standardized blend of plant-sourced polysaccharides.More than 50 patents issued worldwide for this

breakthrough technology.

† Benefits vary by product.



26 Cellular Protection 27Ambrotose AO

Cellular Protection Ambrotose AO®Capsules

Antioxidantsl In part, premature aging is the breakdown of the body’s natural ability to regenerate its trillions of cells and produce new ones. This repair and renewal process goes on every second of every day of your life.

l It has been postulated that naturally occurring invaders, called “free radicals,” can damage cells, interfere with their repair and regeneration, and thereby speed up the aging process.

l Sunlight, physical and emotional stress, and environmental toxins are sources of free radicals that can damage cells and accelerate the aging process.

l Cells can protect themselves from these environmental factors, but research suggests that they require the right nutrients, called antioxidants, to provide proper protection.

l Certain fat- and water-soluble vitamins, minerals and plant phytochemicals are antioxidants that can neutralize free radicals and prevent the damage they cause.

l It has been postulated that premature aging can start to occur when cells don’t get enough antioxidant support, and the body cannot keep up with the demands of damaged cells.

l Antioxidant nutrients are abundant in vine-ripened fruits and vegetables.

Free radicals can attack our cells as many as 10,000 times a day.The right blend of fat- and water-soluble antioxidants may protect our cells from this attack.

Included in OSP

Packets

Ambrotose AO is a scientifically proven antioxidant supplement designed to support optimal health by effectively enhancing antioxidant protection in the body.*l Research has shown that two Ambrotose AO

capsules can increase overall antioxidant protection in humans by 37.9%.† That’s more than two and a half times the ORAC impact of five servings of fruits and vegetables (serum ORAC results).

l Ambrotose AO capsules:

- Help protect against cell damage caused by physical and oxidative stress (free radicals), toxins, environmental stress, and poor diet, all of which can damage cells, tissues, and DNA.*

- Provide plant-sourced ingredients for antioxidant and immune support.*†Comparison of serum ORAC values obtained in two separate clinical studies funded by Mannatech.

According to a study funded by the USDA, five daily servings of fruits and vegetables can increase overall antioxidant protection by 13.9% (serum ORAC results).1 Ambrotose AO capsules can increase overall antioxidant protection in humans by more than two and a half times that amount. Read the full study at: http://bit.ly/11otcQf1Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr 1998;68:1081–7.



28 Cellular Nourishment 29PhytoMatrix

Cellular Nourishment PhytoMatrix®Caplets

Vitamins and Minerals

PhytoBurst® ChewsEssential Nutrition

Your Cells Need Nourishmentl Every cell in your body requires a variety of nutrients to help build and support its proper structure and

function. l Your body is building millions of new cells every second. l There are more than 26 essential vitamins and minerals, and multiple trace elements, that MUST be

obtained through your diet.

Proprietary Hydroponic Growing TechnologyAt the heart of our PhytoMatrix product is a patented, hydroponic cultivation technology that uses the Indian mustard plant nicknamed “nature’s magnet” for its ability to absorb minerals from the soil. These plants are hydroponically grown in solution, allowing them to absorb a controlled amount of concentrated minerals, which are then stored in the plant tissue.

Why is this significant? Because food sources—like Indian mustard—provide minerals in their most natural form, so they can be readily absorbed and utilized by the body. The hydroponic process ensures standardized concentrations of essential minerals that meet minimum requirements with a daily serving of four tablets. Even fresh fruits and vegetables—which usually have high concentrations of vitamins—may be low in essential minerals.

Foods are comprised of synergistic blends of [essential] nutrients bound together into the food matrix.It is the food matrix [blend] that best supports human biological processes.Jacobs DR, Jr., Tapsell LC. Food, not nutrients, is the fundamental unit in nutrition. Nutr Rev 2007;65:439-50.

Included in OSP

Packets

Mannatech’s PhytoMatrix multivitamin/mineral supplement provides the industry’s first standardized blend of food-sourced vitamins, minerals and phytonutrients.PhytoMatrix caplets support:l Cell protection with powerful antioxidants*l Energy production with a full complement of B vitamins*l Heart health with vitamins B6, B12, B3 (niacin), C, and B9 (folic acid)*l Healthy eyesight with vitamins A, C, E, and niacin, plus the mineral zinc*l Immune system function with vitamins A, C, E, B6, and folic acid, plus minerals zinc,

copper and iron*

PhytoBurst Chews: A Delicious Delivery Method for Food-Sourced Nutritionl Delicious fruit-flavored chews (lemon and mixed berry)l Incorporates hydroponic technology found in our PhytoMatrix capletsl Great on-the-go bursts of nutrition



30 Cellular Health 31NutriVerus

Real Nutrition NutriVerusTM

PowderReal Value

Nutrition the Way Your Body Wants it.The Ultimate Solution for Cellular HealthMannatech’s Core Innovations in One ProductNutriVerus™ powder delivers the nutrition your body needs, the way your body wants it. This completely unique supplement combines natural, food-sourced vitamins, minerals, glyconutrients and fat- and water-soluble antioxidants in a nutrient-dense, real-food base of stabilized rice bran and organic fruits and vegetables. The result? Energy-boosting, immune system–supporting nutrition in an environment just right for nutritional synergies to occur, increasing the potential interaction of the individual nutrients.*

Highly Valued Benefits at a Value-Conscious PriceGlyconutrients and food-sourced nutrients for just $2 a day!l Supports cell-to-cell communication through a blend of specific

plant saccharides including glyconutrients*l Offers antioxidant and immune system support*l Supports brain health*l Helps protect your cardiovascular system*l Supports healthy digestion*l Helps your body maintain energy levels*l Provides a natural, food-sourced vitamin/mineral complex for maximum absorption*l Suitable for all ages, including kids age 4 and up

NutriVerus powder features a nutrient-dense, real-food base of stabilized rice bran, organic fruits and vegetables,

antioxidants and glyco- and phytonutrients.

Stabilized Rice Bran (SRB) is one of the most nutrient-dense food ingredients in the world.l Unlike other grains, it is gluten-freel More than 100 antioxidants, metabolic co-

factors, and trace elements in its food matrixl Vitamin E complex with tocopherols and tocotrienolsl Naturally rich in B vitaminsl High in inositoll Rich in phytosterolsl Rich in fatty acidsl Good protein source

l Good source of potassium, magnesium and phosphorus

Learn more about NutriVerus powder and the Real Food Revolution. Watch this video.http://bit.ly/13FgYV0

Essential

Vitamins & Minerals from Real Food

Real-Food Basefrom rice bran and organic

fruits and vegetables

Glyconutrients

Fat- & Water-Soluble

Anti-oxidants

Organic Fruit Blend Organic Vegetable BlendStrawberry Raspberry Broccoli Broccoli SproutsBlueberry Tart Cherry Tomato Carrot

Pomegranate Cranberry Spinach Kale



32 Endocrine System Support 33PLUS

Endocrine System PLUSTM

CapletsSupport

Endocrine System Support

The Endocrine System Is Your Body’s Command Central.When functioning well, its glands direct operations by producing vital hormones that send signals to keep you ready for anything and help your body stay balanced.

Because this important control center ultimately influences almost every cell organ and function of your body, making sure it gets the nutrients it needs is a must. Mannatech’s PLUS™ caplets, can help by keeping this vital system functioning smoothly in a state of equilibrium.*

Mannatech’s PLUS caplets don’t contain hormones. Instead, they provide specific nutrients, including plant sterols, to support your glands’ natural function.*

And because we don’t always eat right, we can miss out on important nutrients like plant sterols and amino acids that help keep our systems functioning well. That’s why Mannatech developed PLUS caplets—to supply the body with a proprietary blend of specific, standardized nutrients, including important plant sterols and amino acids that we may not always get on a consistent basis from diet alone.

Mannatech’s PLUS caplets include a proprietary blend of standardized plant sterols formulated to support a well-functioning endocrine system.*PLUS caplets:

l Furnish raw materials for endocrine support*

l Supply essential amino acids to support natural hormone production*

l Support breast, bone and colon health as well as the immune, nervous and cardiovascular systems*

l Support prostate health*

Amino acids—the “building blocks” of proteinsDid you know that of the 20 amino acids that we all need to survive, the human body produces only 10?

We must rely on our diets for the other half, but not all proteins are created equal. Some contain specific amino acids for hormone production while others do not. And because humans don’t store amino acids in their bodies, we need a steady supply every day.

Included in OSP

Packets



34 Cardiovascular 35Cardiovascular

Cardiovascular System Omega-3with Vitamin D3Support

Healthy Heart

CardioBALANCE®Capsules

Additional Cardiovascular Support

Your body doesn’t produce omega-3.For centuries, people got enough omega-3s through their diets. Not so anymore. Today’s diet trends result in too much omega-6 in our bodies. Even farm-raised fish are often grain fed and contribute more omega-6 than omega-3.

Although omega-6 is important, it competes with omega-3 for space in our cells. Our current diets have created a ratio that ranges as high as 30:1 omega-6 to omega-3. This imbalance has given rise to an unhealthy inflammatory response, which is a key contributor to many of the health concerns in our diet.

A Fat Your Body NeedsThere are good fats and bad, but omega-3 fatty acids are a fat that you absolutely must have.l Help support cardiovascular and heart health*l Help support brain health and function*l Help maintain a healthy immune system and support a healthy inflammatory response—a key contributor

to good health*l Provide support for healthy triglyceride levels already within normal levels*l Vitamin D is essential for calcium absorption*

Learn more about how our Omega-3 with Vitamin D3 is unique. Watch this video.http://bit.ly/186Q7oi

Mannatech’s Omega-3 with Vitamin D3 is your best choice with:l Over 1,000 mg of highly concentrated EPA and DHA per servingl Made from molecularly distilled, high-quality fish oils for

ultra-purityl Pleasant lemon flavor in an easy-to-swallow gel capsulel 830 IU of vitamin D3, a natural and preferred source of

vitamin D

Omega-3 fatty acids

are considered “essential” because

they are vital to your health and

your body cannot produce them.

CardioBALANCE Capsules:l Provide nourishment for cardiovascular health through

a unique herbal vitamin and amino acid blend*

l Help maintain homocysteine levels that are already within normal range*

l Include folate as well as L-arginine, which is thought to increase nitric oxide production—essential in maintaining blood vessel health—as well as CoQ10, which is often depleted by cholesterol-lowering drugs*

Research shows that most people are deficient in omega-3 fatty acids.



36 Digestive 37Digestive

Digestive System GI-ProBalance®Support Slimsticks

Approximately 70% of your immune system which is located in your digestive tract is

dependent on good digestion.

Healthy Digestion

GI-Zyme®Capsules

Healthy Digestion

l One of the digestive system’s most important functions is to process food and absorb all the nutrients our cells can use. It also serves as the first line of defense against harmful bacteria.

l Because the digestive system’s organs rely on nutrients from food, the health of the digestive system depends on the quality of our diet.

l To digest food, the intestines maintain an environment that includes healthy bacteria and enzymes.

l Probiotics are dietary bacteria that assist in digestion. Enzymes regulate the speed of metabolism, among other bodily processes.

l Probiotic bacteria must be regularly replenished. In the past, they were found in many common, raw foods. However, preservatives, pasteurization and other processing have generally eliminated probiotics from today’s foods. This forces the body to dip into and, perhaps, deplete its own supply.

So when your gut is healthy, it helps your whole body stay healthy.

tuned to unleashthe power of

Ambrotose®

PerformanceDeveloped after extensive research on the digestion and beneficial effects of Ambrotose complex, GI-ProBalance slimsticks were formulated to enhance the benefits of Ambrotose products. The specially formulated probiotic blend breaks down the polysaccharides in the Ambrotose products, thereby enhancing the ability of both exceptional products to support the digestive and immune systems.*

Mannatech’s GI-ProBalance slimsticks provide the “right” bacteria to help maintain the microbial balance in a healthy intestine.*

This balance can promote a healthy effect among the various microflora that live in the human intestine, thereby supporting optimal digestive function.*

Mannatech’s GI-Zyme capsules are formulated to:l Help improve the level of digestion*

l Assist in breaking down proteins, fats and carbohydrates*



38 Fat Loss 39OsoLean®

A New Perspective on Sustainable Fat Loss†

OsoLean®Powder

Target Fat Loss

Retaining lean muscle when burning fat is important in maintaining body strength and a healthy metabolism. In a clinical study, the key ingredient in OsoLean powder promoted fat loss and minimized muscle loss when combined with a proper diet and exercise.*

More than just a typical whey protein product, OsoLean powder incorporates a proprietary advanced peptide technology that separates and concentrates specific parts of whey protein, called peptides, to ensure your body receives the optimal level of fat-loss peptides.*

The Answer?SUSTAINABLE weight management from REAL-FOOD SOURCES.

Don’t Make This Common Weight-Management Mistake!When shedding pounds, don’t overlook your body’s basic nutritional needs. Add NutriVerus™ powder to your weight-management regimen and give your body the foundational, whole-food nutrients it craves.

We’re Dieting More OftenThe desire to lose weight is not a new one. But it’s one that’s received unmatched attention in the past thirty years. Conventional wisdom tells us that too many calories and too little exercise are the major contributors to weight gain. So we’ve tried to address those issues in many creative ways. From exercise programs and eating plans, to metabolism-enhancing pills, meal replacements and even surgery, we’ve virtually thrown the kitchen sink at losing weight. l 75 to 100 million Americans diet each year.1 l The typical American dieter now makes four weight-loss

attempts per year—the highest number in 15 years.1

1The weight-loss industry by the numbers, ABC News, May 8, 2012

We’re Spending More Moneyl The U.S. weight-loss market now exceeds $60 billion. U.S. Weight Loss Market Worth $60.9 billion, PRWeb, May 9, 2011

l If you consider that “only” 75 million Americans are trying to lose weight, that’s $800 per person per year!

We’re Gaining More WeightEven when we do lose weight, we seem to have even bigger challenges keeping it off. Many of us lose a few inches today, only to gain it all back—and even more—tomorrow.l Globally, there are more than one billion overweight adults,

and the number is growing. Worldometers.com, Marketdata research 2013

l According to the American Heart Association, 66% of Americans are overweight and 34% are obese.

Trend spotting 2013, Foodnavigator.com, December 3, 2012



40 Performance 41Recovery

Performance RecoveryPerform Better Recover Faster

Mannatech’s advanced Weight and Fitness products are natural and formulated with food-sourced nutrients to help you go the extra mile,

and look amazing while doing it.

SPORT™ capsules:l Help maintain existing normal blood sugar levels and support carbohydrate

utilization*

lA proprietary blend of herbs and herbal extracts

lA plant sterol supplement formulated with a combination of Ambrotose complex and wild yam

AmbroStart® drink mix is a delicious, orange-flavored, energy-releasing supplement that:l Delivers nutrients that provide the body with energy*

l Includes medium-chain triglycerides that are readily broken down into short-chain, free-fatty acids that can be used as fuel for muscles*

l Is a good source of fiber

l Helps support a healthy immune system*

EM∙PACT® citrus-flavored drink mix:l May enhance the body’s ability to use oxygen

during athletic exertion*

l May improve athletic endurance*

l Includes medium-chain triglycerides (MCTs) that are readily broken down into short-chain, free-fatty acids that are used as fuel for muscles*

l Has been clinically shown† to enhance cardiorespiratory fitness and improve endurance*

Our BounceBack® capsules allow you to stay active and mobile.*When taken daily, over time, BounceBack capsules can:

l Help reduce muscle pain and stiffness due to overexertion or physical activity*

l Aid the body’s natural recovery process*

l Support optimal joint and cartilage health*

l Provide immune system support*

Mannatech’s ImmunoSTART® tablets prime your immune system.*If it’s operating well, your immune system will remove toxins and keep you healthy. But, everyday stresses, not eating properly and irregular sleep habits can take a heavy toll on your immune system. These factors may accelerate your use of and need for nutrients. Eventually, your immune system may encounter difficulty keeping up with the demands placed upon it, so it’s critical that you give it the right nourishment.

l Helps build, support and nurture immune system health*

l Engineered with a targeted array of nutrients, including bovine colostrum and lactoferrin that work to stimulate and support the body’s natural immune response*

l Increases plasma levels of neutrophil precursors—neutrophils are the most abundant immune cells and form an integral part of the immune system*

Manna-C™ capsules contain natural forms of vitamin C from wild bush plum and acerola—wild fruits that are considered two of nature’s richest sources of this vitamin.l Includes classic Ambrotose® complex, along with wild bush plum and acerola fruit

extract, both natural sources of vitamin C

l Herbal blend with a natural plant source of vitamin C for the maintenance of good health*

Our Manna-C capsules combine Ambrotose complex plant polysaccharides with an herbal blend that yields natural sources of vitamin C. This specially formulated herbal blend includes lemon verbena, sage, peppermint and other herbs.

†Mannatech-funded clinical studies



42 Protecting the Future 43Children

Protecting Our Future ChildrenStart a Tradition of Good Nutrition

“This could be the first generation of children in the United States that lives less than its parents.”

Richard Carmona,

former Surgeon General of the United States, 2009

The pursuit of wellness is one that lasts a lifetime. Give your child the healthy advantages that come from good nutrition early in life.

Many Mannatech products are appropriate for children. Just check the labels for any possible age and/or directional restrictions. For starters, here

are some products deemed as “favorites” by kids and parents alike.

MannaBears™ GummiesA tasty alternative to sweets full of refined sugars and other “junk” foods, MannaBears gummies include a specially formulated glyconutrient blend as well as 11 dehydrated fruits and vegetables—like broccoli, carrot, cauliflower, tomato, papaya and pineapple—to help protect cells from free radical damage.*

GI-ProBalance® Probiotic SlimsticksSince 70% of your child’s immune system is located in the digestive tract, her body relies on a wide variety of bacteria and other microorganisms to help keep it running properly, including probiotics and prebiotics. Kids love the taste of these delicious slimsticks as much as parents love how they’re working. Recommended for children 4 years of age and older.

NutriVerus™ PowderNutriVerus brings real-food glyconutrient and vitamin/mineral technologies in a nutrient-dense food base of stabilized rice bran and organic fruits and vegetables. Sprinkle it on your child’s food every day to help ensure his meals are more nutritious.Recommended for children 4 years of age and older.

ImmunoSTART® TabletsWith everything going on in their world, your child’s immune system can become overloaded quickly. Give them ImmunoSTART tablets every day to help build, support and nurture immune system health.*Do not give to children under age 4 without adult supervision.



44 The Science of Beauty 45Skin Care

The Science of BeautyHealthy Body, Healthy Hair

We’ve Got You CoveredMannatech products not only help you feel your best, our natural, glyconutrient-

infused skin care products help you look great, too.

FIRM with Ambrotose® Body CreamSuitable for all skin types, this rich, botanically based body cream is a proprietary blend utilizing both science and nature. Formulated without synthetic colors, it’s also paraben-free and contains no mineral oil to clog pores. It will leave your whole body feeling refreshed, hydrated and soft.

The Age-Defying Mannatech LIFT™ Skin Care SystemGlowing, younger-looking skin is achievable at any age. Inspired by French technology and formulated with over 30 botanical ingredients, the Mannatech LIFT skin care system is paraben-free and can help turn back the clock to give skin a more natural, youthful appearance.

With just three easy steps—cleanse, treat and moisturize—plus our Jeunesse 7™ proprietary blend that is known to moisturize, hydrate and reduce the appearance of fine lines and wrinkles, you can say “bonjour” to younger-looking skin in no time.

Aging is natural. Looking your age doesn’t have to be. Look as healthy as you feel with the Mannatech LIFT Skin Care System.

Emprizone® GelRefresh and moisturize dry, itchy skin with hydrating, aloe-based Emprizone gel. With vitamins A and E, it’s pH-balanced to leave your skin feeling soft and revitalized after shaving or waxing. It’s also perfect after drying exposure to the sun and contains no oils or pore-clogging ingredients.

Ageless Beauty Whose Time Has ComeRelease your body’s natural ability to support beautiful, healthy skin through a new, patented microsphere delivery system that nourishes your skin with youth-inducing ingredients in a time-released pattern. This pattern optimizes the natural production of skin cells at all levels by delivering naturally sourced glycans, featuring Manapol® powder.

Finally, what we’ve all been looking for: Youth.Clinical studies of key ingredients in Mannatech Ūth Crème have shown to:l Help reduce the appearance of wrinkles

l Help reduce the appearance of lines

l Increase moisture and hydration

l Give the skin greater luminosity

l Even skin’s tone

l Improve the elasticity of the skin

l Refine pore size

46 How You Can Help 47Please Join Us!

Change YOUR WORLD Change THE WORLD!

†Mission 5 MillionSM donations are generated through monthly automatic product orders.‡4Free Member Discount Program credits are based on monthly automatic product orders.

Consume

One Simple ActSM

Become a CUSTOMER and help nourish a child in need.†

Share

4Free Discount ProgramAs a Member, refer a few people, earn discounts on your orders‡ (up to FREE!) and help nourish more children.

Champion

Become a ChampionHelp us change the world while creating a life of significance for yourself.

—Our Goal—Linking five million consumers

with five million children in need.

PLEASE JOIN US!Find out how people

just like you are playing a crucial role in the fight

against global malnutrition.

16931.1113

Item Number: 1275101

Mannatech, Incorporated 600 S. Royal Lane, Suite 200Coppell, TX 75019Mannatech.com

Advanced Ambrotose, AmbroStart, Ambrotose, Ambrotose AO, BounceBack, CardioBALANCE, EM•PACT, Emprizone, FIRM with Ambrotose, GI-ProBalance, Give for Real and Design, GI-Zyme, ImmunoSTART, Jeunesse 7, Live for Real, Manapol, MannaBears, Manna-C, Mannatech LIFT, M5M, Mission 5 Million and Design, NutriVerus, One Simple Act, OsoLean, PhytoBlend, PhytoBurst, PhytoMatrix, PLUS, Real Food Technology, SPORT, Stylized M Design and Mannatech are trademarks of Mannatech, Incorporated.

Be the Change You Want to See.Helping to nourish many of the world’s most vulnerable

children is as easy as simply nourishing yourself. Just purchase the daily supplements you need, and

Mannatech, through MannaRelief, helps a child in need.

When you do this, MannaRelief will provide a monthly donation of PhytoBlend™ powder; a Real Food Technology® solution!

That’s REAL PLANT & FOOD-BASED NUTRITION to help battle malnutrition in developing countries around the world.

Partner with Mannatech through our MISSION 5 MILLIONSM movement, and be a part of the change you want to see in the world! For more information about this important program, visit www.Mannatech.com.

Hope for the Future.

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