Marcel Phil ipp Trefny, PhD

Name: Marcel Philipp Trefny Titles: Dr. phil. (PhD) E-mail: marcel.trefny@unibas.ch Date of Birth: 29.10.1992 Tel.: +41612652355 (lab) Nationality: Swiss ORCID: 0000-0001-6755-7899

Work July 2021 – ongoing Project leader in the laboratory of Prof. Alfred Zippelius. Co-supervision of two PhD

students and collaborative projects with two postdoctoral researchers.

Feb 2020 – July 2021 Postdoctoral researcher in the laboratory of Prof. Alfred Zippelius. Studying the mechanisms of T cell dysfunction. Work includes working in multiple multinational projects, supervision of two PhD students, writing of publications and grant applications.

May 2016 – Feb 2020 PhD in Cancer Immunology in the laboratory of Prof. Zippelius at the Department of Biomedicine, University and University Hospital of Basel. Studying the mechanisms and role of T cell dysfunction and NK cells in human cancers.

Education 23rd February 2020 PhD Defence (“Resistance Mechanisms in Cancer Immunotherapy”) at the University

of Basel with Prof. Alfred Zippelius, Prof. Christoph Hess and Prof. Pedro Romero (external expert) -summa cum laude (highest honors)

2014-2016 Master in Molecular Life Sciences, Specialization Biochemistry/Chemical Biology University of Bern -summa cum laude

Master thesis “Mitochondria and Cellular Energetics of Human Dermal Stem Cells” Group of Prof. Hans-Uwe Simon, Institute of Pharmacology Bern September 2014 – February 2016

2011-2014 Bachelor in Biochemistry and Molecular Biology University of Bern -summa cum laude

Bachelor thesis “Drug discovery for DMT1 and SNAT2, From Assay Validation to Hit Characterization” Group of Prof. Matthias Hediger, Institute of Biochemistry and Biomedicine Bern Spring 2014, 10 weeks + 3 weeks extracurricular -summa cum laude

Languages German Mother tongue (Swiss German) English Fluent oral and written French Basic oral and written

Professional Activities Jan 2020 – ongoing Reviewer for Cancer Immunology, Immunotherapy, Springer Nature (4 manuscripts)

Reviewer for Nature Communications, Springer Nature (1 manuscript) Reviewer for Journal for the Immunotherapy in Cancer JITC (1 manuscript)

25.-28. September 2019 CRI-CIMT-EATI-AACR Fifth International Cancer Immunotherapy Conference, Paris, France Poster Presentation

1.-5. July 2019 Establishing High-Throughput Drug Screening Assays at the National Phenotypic Screening Center, Dundee University, Dundee, Scotland UK

8.-12. July 2019 Scientific Exchange Stay in the Laboratory of Prof. Gillian Griffiths at the Cambridge Institute for Medical Research, Cambridge, UK

13.-15. June 2019 Scientific Retreat of the DBM PhD Students, Schwarzenburg, Switzerland 2nd Price for Best Oral Presentation

12.-16. January 2019 CIMT Academy of Translational Cancer Immunology Winter School, Obergurgl, Austria Oral Presentation

24.-26. June 2018 Translational Immunometabolism Cell Symposium, Basel Switzerland 7.-9. January 2018 30th Wolfsberg Meeting of the Swiss Immunology PhD Students

Oral Presentation 6.-9. September 2017 CRI-CIMT-EATI-AACR Fourth International Immunotherapy Conference, Mainz

Germany 23.-26. August 2015 Novartis International Biotechnology Leadership Camp 2015, Basel Switzerland

Professional Education 10.-11. December 2020 Statistics and Machine Learning for Life Sciences, SIB, Basel 9. September 2019 Bioinformatics workshop on multi-sample single-cell RNAseq analysis (muscat), SIB,

Basel 23. May 2018 Bioinformatics course “Inferring gene regulatory networks from high-throughput data

with ISMARA”, SIB Basel 14. February 2018 Bioinformatics course on high performance computing and Linux systems, SIB Basel 14.-15. August 2017 Bioinformatics course “Introduction to RNA-Sequencing”, University of Basel 3. December 2015 Joint Information Day on Good Cell Culture Practice, Human Stem Cells and

Organoids, Konstanz, Germany

Grants and Funding November 2020 Dr. Arnold U. und Susanne Huggenberger-Bischoff Stiftung zur Krebsforschung To Dr. Marcel Trefny (main applicant) April 2019 Swiss National Science Foundation – 3-year Project Grant To Prof. Zippelius (co-writing and co-design) Dez 2018 Cancer League Basel (Krebsliga beider Basel) To Prof. Zippelius (1-year continuation of PhD project, co-writing and co-design)

Computer Skills • Advanced programming in R and Bioconductor packages including analysis of RNAseq, pooled CRISPR-

Cas9 screens, single-cell RNAseq, imaging cell-cell interaction experiments, GLM, statistics and plotting • Basic programming and scripting in python, bash/Linux, Java, ImageJ, php, HTML • Proficiency in MS Office