MARIANO BARBACID: COMPLETE PUBLICATION LIST 1. M. Barbacid and D. Vázquez. (1973). Preparation of [3H] Anisomycin and [3H] Gougerotin: Binding to Eukaryotic Ribosome. In: Methods in Enzymology. Nucleic Acids and Protein Synthesis, Vol. XXX, Part. F., (K. Moldave and L. Grossman, eds.). Academic Press (New York-London) pp. 426-439. 2. M. Barbacid and D. Vázquez. (1973). Preparation of Pure [3H] Anisomycin by Tritium Exchange Labeling. Anal. Biochem, 56:16-25. 3. L. Carrasco, M. Barbacid and D. Vázquez. (1973). The Trichodermin Group of Antibiotics. Inhibitors of Peptide Bond Formation by Eukaryotic Ribosome. Biochim. Biophys. Acta, 312:368-376. 4. M. Barbacid and D. Vázquez. (1973). [3H] Anisomycin Binding to Eukaryotic Ribosome. J. Mol. Biol., 84:603-623. 5. A. Contreras, M. Barbacid and D. Vázquez. (1973). Comparative Aspects of the Action of Chloramphenicol and Thiamphenicol on Bacterial Ribosome. Postgraduate Med. J., 50:50-53, (Suppl. 5). 6. D. Vázquez, M. Barbacid and L. Carrasco. (1974). Inhibitors of Mammalian Protein Synthesis. In: Modern Trends in Human Leukemia, (R. Neth, R.C. Gallo, S. Spiegelman and F. Stohlman, eds.), Lehmans Verlag (Munich) pp. 327-340. 7. A. Contreras, M. Barbacid and D. Vázquez. (1974). Binding to Ribosome and Mode of Action of Chloramphenicol Analogues. Biochim. Biophys. Acta., 349:376-388. 8. M. Barbacid and D. Vázquez. (1974). Binding of acetyl-[l4C] Trichodermin to the Peptidyl Transferase Center of Eukaryotic Ribosome. Eur. J. Biochem., 44:437-444. 9. M. Barbacid and D. Vázquez. (1974). [G-3H] Gougerotin Binding to Ribosome. Heterogeneity of Eukaryotic Ribosome. Eur. J. Biochem., 44:445-453. 10. M. Barbacid and D. Vázquez. (1975). Antibiotic Binding to Ribosome From Eukaryotic Cells. In: Progress in Chemotherapy, (G.K.Daikos, ed.). American Society for Microbiology (Washington) pp. 436-439. 11. M. Barbacid and D. Vázquez. (1975). Ribosome Changes During Translation. J. Mol. Biol., 93:449-463. 12. M. Barbacid, M. Fresno and D. Vázquez. (1975). Inhibitors of Polypeptide Elongation on Yeast Polysomes. J. Antibiot., 28:453-462. 13. M. Barbacid, A. Contreras and D. Vázquez. (1975). The Mode of Action of Griseoviridin at the Ribosome Level. Biochim. Biophys. Acta., 395:347-354.

2

14. D. Vázquez, M. Barbacid and R. Fernández-Muñoz. (1975). Antibiotic Action on the Ribosomal Peptidyl Transferase Center. In: Drug-Receptor Interactions in Antimicrobial Chemotherapy, Vol. 1, (J. Drews and F.E. Hahn, eds.), Springer-Verlag (Berlin-New York) pp. 193-216. 15. M. Barbacid. (1976). Interacción de Antibióticos con el Centro Activo Peptidil Transferasa del Ribosoma Eucariotico. Rev. Quimioterapia 3:1-36. 16. M. Barbacid, J.R. Stephenson and S.A. Aaronson. (1976). Structural Polypeptides of Mammalian Type-C RNA Viruses: Isolation and Immunology Characterization of a Low Molecular Weight Polypeptide, pl0. J. Biol. Chem., 251:4859-4866. 17. M. Barbacid, J.R. Stephenson and S.A. Aaronson. (1976). The gag Gene of Mammalian Type-C RNA Tumor Viruses. Nature, 262:554-559. 18. M. Barbacid, J.R. Stephenson and S.A. Aaronson. (1977). Evolutionary Relationships Between gag Gene-Coded Proteins of Murine and Primate Endogenous Type-C RNA Viruses. Cell, 10:641-648. 19. J.R. Stephenson, M. Barbacid, S.R. Tronick, S. Hino and S.A. Aaronson. (1977). Proteins of Type-C RNA Tumor Viruses. In: Cancer Research: Cell Biology, Molecular Biology and Tumor Virology, (R. Gallo, ed.), CRC Press (Cleveland), pp. 37-50. 20. J.M. Krakower, M. Barbacid and S.A. Aaronson. (1977). Radioimmunoassay for Mammalian Type-C Viral Reverse Transcriptase. J. Virol., 22:331-339. 21. J.M. Krakower, M. Barbacid and S.A. Aaronson. (1977). Differential Synthesis of Mammalian Type-C Viral Gene Products in Infected Cells. J. Virol., 24:1-7. 22. M. Barbacid, S.R. Tronick and S.A. Aaronson. (1978). Isolation and Characterization of an Endogenous Type-C RNA Virus of Mink (MvlLu) Cells. J. Virol., 25:129-137. 23. M. Barbacid, K.C. Robbins, S. Hino and S.A. Aaronson. (1978). Genetic Recombination Between Mouse Type-C RNA Viruses: A Mechanism for Endogenous Viral Gene Amplification in Mammalian Cells. Proc. Natl. Acad. Sci. U.S.A., 75:923-927. 24. M. Barbacid and S.A. Aaronson. (1978). Membrane Properties of the gag Gene-Coded pl5 Protein of Murine Type-C RNA Tumor Viruses. J. Biol. Chem., 253:1408-1414. 25. S.A. Aaronson, M. Barbacid, S. Hino, S. Tronick and J.M. Krakower. (1978). Common Progenitors in the Evolution of Mammalian Retroviruses. In: Advances in Comparative Leukemia Research, (D.S. Yohn and P. Bentvelzen, eds.), Elsevier/North Holland Press (Amsterdam) pp. 127-134. 26. S.A. Aaronson and M. Barbacid. (1978). Origin and Biological Properties of a New BALB/c Mouse Sarcoma Virus (BALB-MSV). J. Virol., 27:366-373.

3

27. M. Barbacid, D.H. Troxler, E.M. Scolnick and S.A. Aaronson. (1978). Analysis of Translational Products of Friend Strain of Spleen Focus-Forming Virus. J. Virol., 27:826-830. 28. K.J. Porzig, M. Barbacid and S.A. Aaronson. (1979). Biological Properties and Translation Products of Three Independent Isolates of Feline Sarcoma Virus. Virology, 92:91-107. 29. M. Barbacid, K.C. Robbins and S.A. Aaronson. (1979). Wild Mouse RNA Tumor Viruses: A Nongenetically Transmitted Virus Group Closely Related to Exogenous Leukemia Viruses of Laboratory Mouse Strains. J. Exp. Med.,149:254-266. 30. M. Barbacid, J. Steel, L.K. Lon and S.A. Aaronson. (1979). Isolation and Genetic Analysis of Mammalian Type-C RNA Recombinant Viruses. In: Advances in Medical Oncology, Research and Education, Vol. 1: Carcinogenesis, (G.P. Margison, ed.), Pergamon Press (Oxford) pp. 43-49. 31. M. Barbacid, E. Hunter and S.A. Aaronson. (1979). Avian Reticuloendotheliosis Viruses: Evolutionary Linkage to Mammalian Type-C Retroviruses. J. Virol., 30:508-514. 32. P.R. Andersen, M. Barbacid, S.R. Tronick, H.F. Clark and S.A. Aaronson. (1979). Evolutionary Relatedness of Viper and Primate Endogenous Retroviruses. Science, 204:318-321. 33. K.C. Robbins, M. Barbacid, K.J. Porzig and S.A. Aaronson. (1979). Involvement of Different Exogenous FeLV Subgroups in the Generation of Independent Feline Sarcoma Virus Isolates. Virology, 97:1-11. 34. M. Barbacid, L.K. Long and S.A. Aaronson. (1980). Major Structural Proteins of Type-B, Type-C and Type-D Oncoviruses Share Interspecies Antigenic Determinants. Proc. Natl. Acad. Sci. U.S.A., 77:72-76. 35. M. Barbacid, M.D. Daniel and S.A. Aaronson. (1980). Endogenous Oncoviruses of New World Monkeys: Immunology Relationships of OMC-l, an Endogenous Virus of Owl Monkeys, with Mammalian and Avian Type-C Viruses. J. Virol., 33:561-566. 36. M. Barbacid, D. Bolognesi and S.A. Aaronson. (1980). Humans Have Antibodies Capable of Recognizing Oncoviral Glycoproteins: Demonstration that these Antibodies are Formed in Response to Cellular Modification of Glycoproteins rather than as Consequence of Exposure to Virus. Proc. Natl. Acad. Sci. U.S.A., 77:1617-1621. 37. S.A. Aaronson and M. Barbacid. (1980). Viral Genes Involved in Leukemogenesis. I. Generation of Recombinants Between Oncogenic and Non-Oncogenic Mouse Type-C Viruses in Tissue Culture. J. Exp. Med., 151:467-480. 38. M. Barbacid, A.V. Lauver and S.G. Devare. (1980). Biochemical and Immunological Characterization of Polyproteins Coded for by the McDonough, Gardner-Arnstein, and Snyder-Theilen Strains of Feline Sarcoma Virus. J. Virol., 33:196-207.

4

39. M. Barbacid, J.M. Krakower, D.P. Bolognesi and S.A. Aaronson. (1980). The Search for Evidence of Humoral Immunity to Oncoviruses in Man. In: Cold Spring Harbor Conferences on Cell Proliferation, Vol. 7: Viruses in Naturally Occurring Cancers, (G.J. Todaro, M. Essex and H. zur Hausen, eds.), Cold Spring Harbor Laboratory Press (Cold Spring Harbor, New York) pp. 869-883. 40. L. Benade and M. Barbacid. (1980). Polymorphism Among the Major Core Proteins of C57BL B-Tropic Murine Leukemia Viruses. Virology, 106:387-390. 41. M. Barbacid, K. Beemon and S.G. Devare. (1980). Origin and Functional Properties of the Major Gene Product of the Snyder-Theilen Strain of Feline Sarcoma Virus. Proc. Natl. Acad. Sci. U.S.A., 77:5158-5163. 42. M. Barbacid, A.V. Lauver, L.K. Long and S.D. Devare. (1980). The Major Gene Products of the Snyder-Theilen and Gardner-Arstein Strains of Feline Sarcoma Viruses Have a Common Cellular Origin and Similar Functional Properties. In: Feline Leukemia Virus, (W.D. Hardy, M. Essex and A.J. Mc Clelland, eds.), Elsevier/North Holland Press (New York) pp. 309-320. 43. M.B. Gardner, M. Barbacid, S. Rasheed, C. Grant and S.A. Aaronson. (1980). Humoral Immunity in Natural FeLV-Exposed and Experimental FeSV-Inoculated House Cats. In: Feline Leukemia Virus, (W.D. Hardy, M. Essex and A.J. Mc Clelland, eds.), Elsevier/North Holland Press (New York), pp. 159-169. 44. S.A. Aaronson, M. Barbacid, C.Y. Dunn and E.P. Reddy. (1981). Genetic Approaches Toward Elucidating the Mechanisms of Type-C Virus Induced Leukemia. In: Modern Trends in Human Leukemia, Vol 4. (R. Neth, ed.) Springer-Verlag, (Berlin/Heidelberg), pp. 455-459. 45. M. Barbacid. (1981). Cellular Transformation by Subgenomic Feline Sarcoma Virus DNA. J. Virol., 37:518-523. 46. M. Barbacid, M.L. Breitman, A.V. Lauver, L.K. Long and P.K. Vogt. (1981). The Transformation-Specific Proteins of Avian (Fujinami, PRC II) and Feline (Snyder-Theilen, Gardner-Arnstein) Sarcoma Viruses are Immunologically Related. Virology, 110:411-419. 47. M. Barbacid, L. Donner, S.K. Ruscetti and C.J. Sherr. (1981). Transformation Defective Mutants of Snyder-Theilen Feline Sarcoma Virus Lack Tyrosine-Specific Protein Kinase Activity. J. Virol., 39:246-254. 48. J. Merregaert, M. Barbacid and S.A. Aaronson. (1981). Recombinants Between ts Mutants of Rauscher Murine Leukemia Virus and BALB:virus-2: Genetic Mapping of the Rauscher-MuLV Genome. J. Virol., 39:219-228. 49. S. Oroszlan, M. Barbacid, T.D. Copeland, S.A. Aaronson and R.V. Gilden. (1981). Chemical and Immunological Characterization of the Major Structural Protein (p28) of MMC-l, a Rhesus Monkey Endogenous Type C Virus: Homology With the Major Structural Protein of the Avian Reticuloendotheliosis Virus. J. Virol., 39:845-854.

5

50. M. Barbacid and A.V. Lauver. (1981). The Gene Products of McDonough Feline Sarcoma Virus Exhibit an In Vitro Associated Protein Kinase Activity that Phosphorylates Tyrosine Residues: Lack of Detection of This Enzymatic Activity In Vivo. J. Virol., 40:812-821. 51. S. Rasheed, M. Barbacid, S.A. Aaronson and M.B. Gardner. (1982). Origin and Biological Properties of a New Feline Sarcoma Virus. Virology, 117:238-244. 52. S. Pulciani, E. Santos, A. Lauver, L.K. Long, K.C. Robbins and M. Barbacid. (1982). Oncogenes in Human Tumor Cell Lines: Molecular Cloning of a Transforming Gene From Human Bladder Carcinoma Cells. Proc. Natl. Acad. Sci. U.S.A., 79:2845-2849. 53. E. Santos, S. Tronick, S.A. Aaronson, S. Pulciani and M. Barbacid. (1982). The T24 Human Bladder Carcinoma Oncogene is an Activated Form of the Normal Human Homologue of BALB- and Harvey-MSV Transforming Genes. Nature, 298:343-347. 54. E.P. Reddy, R.K. Reynolds, E. Santos and M. Barbacid. (1982). A Point Mutation is Responsible for the Acquisition of Transforming Properties by the T24 Human Bladder Carcinoma Oncogene. Nature, 300:149-152. 55. S. Pulciani, E. Santos, A.V. Lauver, L.K. Long, S.A. Aaronson and M. Barbacid. (1982). Oncogenes in Solid Human Tumors. Nature, 300:539-542. 56. O.W. McBride, D.C. Swan, E. Santos, M. Barbacid, S.R. Tronick and S.A. Aaronson. (1982). Localization of the Normal Allele of T24 Human Bladder Carcinoma Oncogene to Chromosome 11. Nature, 300:773-774. 57. S. Pulciani, E. Santos, A. Lauver, L.K. Long and M. Barbacid. (1982). Transforming Genes in Human Tumors. J. Cell. Biochem., 20:51-61. 58. E. Santos, S. Pulciani and M. Barbacid. (1983). Characterization of a Human Transforming Gene Isolated From T24 Bladder Carcinoma Cells. Fed. Proceedings, 43:2280-2286. 59. U.R. Rapp and M. Barbacid. (1983). Activation of a Type C Virus Particle in Cells From the Inbred Mouse Strain 129/J: Antigenic Relationship with the Horizontally Transmitted Type C Viruses of Primates. Arch. Virol., 76:373-379. 60. M. Barbacid. (1983). Human Oncogenes. 1984 McGraw-Hill Year Book of Science and Technology, McGraw-Hill (New York), pp. 309-313. 61. E. Santos, E.P. Reddy, S. Pulciani, R. Feldmann and M. Barbacid. (1983). Spontaneous Activation of a Human Proto-Oncogene. Proc. Natl. Acad. Sci. U.S.A., 80:4679-4683. 62. S. Sukumar, V. Notario, D. Martin-Zanca and M. Barbacid. (1983). Induction of Mammary Carcinomas in Rats by Nitroso-Methyl-Urea Involves the Malignant Activation of the H-ras-l Locus by Single Point Mutations. Nature, 306:658-661.

6

63. E. Santos, D. Martin-Zanca, E.P. Reddy, M.A. Pierotti, G. Della Porta and M. Barbacid. (1984). Malignant Activation of a K-ras Oncogene in Lung Carcinoma but Not in Normal Tissue of the Same Patient. Science, 223:661-664. 64. S. Sukumar, S. Pulciani, J. Doniger, J.A. DiPaolo, C. Evans, B. Zbar and M. Barbacid. (1984). A Transforming ras Gene in Tumorigenic Guinea Pig Cell Lines Initiated by Diverse Chemical Carcinogens. Science, 223:1197-1199. 65. V. Notario, S. Sukumar, E. Santos and M. Barbacid. (1984). A Common Mechanism for the Malignant Activation of ras Oncogenes in Human Neoplasia and in Chemically-Induced Animal Tumors. In The Cancer Cell, (A. Levine, G. Vande Woude and J. Watson, eds), Cold Spring Harbor Laboratory Press (Cold Spring Harbor, New York), pp. 425-432. 66. J.C. Lacal, E. Santos, V. Notario, M. Barbacid, S. Yamazaki, H. Kung, C. Seamans, S. McAndrew and R. Crowl. (1984). Expression of Normal and Transforming H-ras Genes in E. coli and Purification of Their Encoded p21 Proteins. Proc. Natl. Acad. Sci. U.S.A., 81: 5305-5309. 67. S. Sukumar, E. Santos, D. Martin-Zanca, A.V. Arthur, L.K. Long and M. Barbacid. (1984). Transforming ras Genes in Human Neoplasia and in Chemically Induced Animal Tumor Systems. In: UCLA Symposium on Genes and Cancer (M. Bishop, J. Rowley and M. Greaves, eds.), pp. 353-371. 68. M. Barbacid. (1985). Oncogenes in Human Cancers and in Chemically Induced Animal Tumors. Progress in Medical Virology, S. Karger AG (Basel), 32:86-100. 69. E. Santos, S. Sukumar, D. Martin-Zanca, H. Zarbl and M. Barbacid. (1985). Transforming ras Genes. In: Viruses and Cancer, (P.W.J. Rigby & N.M. Wilkie, eds.), The Society for General Microbiology, Cambridge Univ. Press, pp. 291-313. 70. S. Sukumar, H. Zarbl, E. Santos, D. Martin-Zanca, A. Arthur, L.K. Long and M. Barbacid. (1985). ras Oncogenes & Carcinogenesis. In: Macrophage Biology (S. Reichard, M. Kojima, eds.), Alan R. Liss, Inc., New York, pp. 745-766. 71. H. Zarbl, S. Sukumar, D. Martin-Zanca, E. Santos and M. Barbacid. (1985). Molecular Assays for Detection of ras Oncogenes in Human & Animal Tumors. In Mammalian Cell Transformation: Mechanisms of Carcinogenesis and Assays for Carcinogens, (J.C. Barrett & R.W. Tennant, eds.), Raven Press, New York, pp. 1-16. 72. H. Zarbl, S. Sukumar, A. Arthur, D. Martin-Zanca and M. Barbacid. (1985). Direct Mutagenesis of H-ras-l Oncogenes by N-Nitroso-N-Methylurea During Initiation of Mammary Carcinogenesis in Rats. Nature, 315:382-385. 73. S. Pulciani, E. Santos, L.K. Long, V. Sorrentino and M. Barbacid. (1985). ras Gene Amplification and Malignant Transformation. Mol. Cell. Biol., 5:2836-2841. 74. M. Barbacid. (1985). Human Oncogenes. In: Important Advances in Oncology 1986, (V. Devita, S. Hellman, and S. Rosenberg, eds.), J.B. Lippincott Company, Philadelphia, PA, pp. 3-22.

7

75. A. Puga, J. Gomez-Marquez, P.R. Brayton, E.M. Cantin, L.K. Long, M. Barbacid and A.L. Notkins. (1985). The Immediate-Early Enhancer Element of Herpes Simplex Virus Type 1 Can Replace a Regulatory Region of c-H-ras-l Oncogene Required for Transformation. J. Virol., 54:879-881. 76. H. Zarbl, S. Sukumar, A. Arthur, D. Martin-Zanca and M. Barbacid. (1986). Activation of H-ras-l Oncogenes by Chemical Carcinogens. In: Mechanisms of DNA Damage & Repair: Implications for Carcinogenesis & Risk Assessment, (M. Simil, L. Grossman, & A. Upton, eds), Plenum Press, New York, pp. 385-398. 77. D. Martin-Zanca, S. Hughes and M. Barbacid. (1986). A Human Oncogene Formed by the Fusion of Truncated Tropomyosin & Protein Tyrosine Kinase Sequences. Nature, 319:743-748. 78. M. Barbacid. (1986). ras Oncogenes in Neoplastic Development. In: General Motors Cancer Research Foundation "Accomplishments in Cancer Research 1985" (J.G. Fortner, ed.), pp. 179-187. 79. M. Barbacid. (1986). Oncogenes and Human Cancer: Cause or Consequence? Carcinogenesis, 7:1037-1042. 80. M. Barbacid, S. Sukumar and H. Zarbl. (1986). Activation of ras Oncogenes by Chemical Carcinogens. In: Gene Analysis Techniques, Fourth Volume "Oncogenes and Growth Factors" (J.G. Chirikjian, T.S. Papas, eds.) Elsevier Publishers, pp. 1-38. 81. M. Barbacid. (1986). Mutagens, Oncogenes & Cancer. Trends in Genetics, 2:188-192. 82. D. Martin-Zanca, G. Mitra, L.K. Long and M. Barbacid. (1986). Molecular Characterization of the Human trk Oncogene. Proceedings of the Cold Spring Harbor Symposia on Quantitative Biology, 51:983-992. 83. M. Barbacid. (1987). ras Genes. Ann. Rev. Biochem., 56:779-827. 84. S. Sukumar and M. Barbacid. (1987). The Role of ras Oncogenes in Chemically-Induced Tumors. In: Molecular Mechanisms of Carcinogenic and Antitumor Activity (C. Chagas and B. Pullman, eds.), Pontifical Academy of Sciences, Italy, pp. 35-53. 85. M. Barbacid. (1987). Involvement of ras Oncogenes in the Initiation of Carcinogen-Induced Tumors. In: "Oncogenes and Cancer" (S.A. Aaronson, J.M. Bishop, T. Sugimura, M. Terada, K. Toyoshima, & P.K. Vogt, eds)., Japan Scientific Press, Japan, and VNU Science Press BV, The Netherlands, pp. 43-54. 86. G. Mitra, D. Martin-Zanca and M. Barbacid. (1987). Identification and Biochemical Characterization of p70trk the Gene Product of the Human trk Oncogene. Proc. Natl. Acad. Sci. U.S.A., 84:6707-6711. 87. M. Barbacid. (1987). ras Oncogenes in Human and Carcinogen-Induced Animal Tumors. In: Cellular Oncogene Activation (G. Klein, ed.), Marcell Dekker, Inc., New York, pp. 121-147.

8

88. M. Barbacid. (1988). Oncogenes and Cancer. In: Recientes Progresos en Etiologia del Cancer y Patologia Molecular, (M. Barbacid, F. Mayor, S. Ochoa, eds.), Fundacion Ramon Areces, Spain, pp. 197-240. 89. R. Oskam, F. Coulier, M. Ernst, D. Martin-Zanca and M. Barbacid. (1988). Frequent Generation of trk Oncogenes by in vitro Recombination. Proc. Natl. Acad. Sci. U.S.A., 80:2964-2969. 90. S. Sukumar, W.P. Carney and M. Barbacid. (1988). Independent Molecular Pathways in Initiation and Loss of Hormone Responsiveness of Breast Carcinomas. Science, 240:524-526. 91. M. Barbacid. (1988). From Retroviral to Human Oncogenes: The Molecular Basis of Human Cancer. In: Retroviruses & Disease. (M.E. Pullman, H. Hanafusa, A. Pinter, eds.), Academic Press, New York, pp. 66-94. 92. R. Kumar and M. Barbacid. (1988). Oncogene Detection at the Single Cell Level. Oncogene, 3:647-652. 93. F. Coulier, D. Martin-Zanca, M. Ernst and M. Barbacid. (1989). Mechanism of Activation of the Human trk Oncogene. Mol. Cell. Biol., 9:15-23. 94. D. Martin-Zanca, R. Oskam, G. Mitra, T. Copeland and M. Barbacid. (1989). Molecular and Biochemical Characterization Of The Human trk Proto-Oncogene. Mol. Cell. Biol., 9:24-33. 95. G. Mitra, G.T. Pauly, R. Kumar, G.K. Pei, S.H. Hughes, R.C. Moschel and M. Barbacid (1989). Molecular Analysis of O6-substituted Guanine-Induced Mutagenesis of ras Oncogenes. Proc. Natl. Acad. Sci. U.S.A., 86:8650-8654. 96. R. Kumar, S. Sukumar and M. Barbacid. (1989). Detection of ras Oncogenes at the Single Cell Level. In Cancer Cells, Vol 7: Molecular Diagnostics of Human Cancer. Cold Spring Harbor Laboratory (Cold Spring Harbor, New York), pp. 151-156. 97. S. Katzav, D. Martin-Zanca and M. Barbacid. (1989). vav, a Novel Human Oncogene Derived From a Locus Ubiquitously Expressed in Hematopoietic Cells. EMBO J., 8:2283-2290. 98. S. Katzav, D. Martin-Zanca, M. Barbacid, A.-M. Hedge, R. Isfort and J.N. Ihle. (1989). The trk Oncogene Abrogates Growth Factor Requirements and Transforms Hematopoietic Cells. Oncogene, 4:1129-1135. 99. R. Klein, L.F. Parada, F. Coulier and M. Barbacid. (1989). trkB, a Novel Tyrosine Protein Kinase Receptor Expressed During Mouse Neural Development. EMBO J., 8:3701-3709. 100. S. Sukumar and M. Barbacid. (1990). Specific Patterns of Oncogene Activation in Transplacentally Induced Tumors. Proc. Natl. Acad. Sci. U.S.A., 87:718-722.

9

101. D. Martin-Zanca, M. Barbacid and L.F. Parada. (1990). Expression of the trk Proto-oncogene is Restricted to the Sensory Cranial and Spinal Ganglia of Neural Crest Origin in Mouse Development. Genes & Develop., 4:683-694. 102. A. Cuadrado, N. Talbot and M. Barbacid. (1990). C127 Cells Resistant to Transformation by Tyrosine Protein Kinase Oncogenes. Cell Growth & Differ., 1:9-15. 103. R. Kumar, S. Sukumar and M. Barbacid (1990) Activation of ras Oncogenes Preceding the Onset of Neoplasia. Science, 248:1101-1104. 104. R. Klein, D. Conway, L.F. Parada and M. Barbacid. (1990). The trkB Tyrosine Protein Kinase Gene Codes for a Second Neurogenic Receptor That Lacks the Catalytic Kinase Domain. Cell, 61:647-656. 105. C. Martinerie, L.A. Cannizzaro, C.M. Croce, K. Huebner, S. Katzav and M. Barbacid. (1990). The Human vav Proto-oncogene Maps to Chromosome Region l9pl2-19pl3.2. Human Genetics, 86:65-68. 106. M. Barbacid. (1990). ras Oncogenes: Their Role in Neoplasia. European Journal of Clinical Investigation, 20:225-235. 107. D. Martin-Zanca, R. Klein, M. Barbacid and L.F. Parada. (1990). Expression of the trk Protein Tyrosine Kinase Receptor Gene Family is Limited Exclusively to the Murine Embryonic and Mature Nervous System. In The Avian Model in Developmental Biology: From Organism to Genes (CNRS, Paris, France), pp. 291-302. 108. R. Klein, D. Martin-Zanca, M. Barbacid and L.F. Parada. (1990). Expression of the Tyrosine Kinase Receptor Gene trkB is Confined to the Murine Embryonic and Adult Nervous System. Development, 109:845-850. 109. F. Coulier, R. Kumar, M. Ernst, R. Klein, D. Martin-Zanca and M. Barbacid. (1990). Human trk Oncogenes Activated by Point Mutation, In-Frame Deletion and Duplication of the Tyrosine Kinase Domain. Mol. Cell. Biol., 10:4202-4210. 110. V. Manne, D. Roberts, A. Tobin, E. O'Rourke, M. De Virgilio, C. Meyers, N. Ahmed, B. Kurz, M. Resh, H.-F. Kung and M. Barbacid. (1990). Identification and Preliminary Characterization of Farnesyl-Protein Transferase. Proc. Natl. Acad. Sci. U.S.A., 87:7541-7545. 111. D.S. Garlick, S. Sukumar, M. Barbacid, D. Petit, P.J. Hamer, I. Leav, J.A. Lavecchio, K.L. Trimpe and W.P. Carney (1991). Generation of Monoclonal Antibodies Specific for ras p21 Glu-12 Oncoproteins: Detection in Carcinogen-Induced Mammary Carcinomas. Hybridoma, 10:95-102. 112. J. Coppola, S. Bryant, T. Koda, D. Conway and M. Barbacid. (1991). Mechanism of Activation of the vav Proto-Oncogene. Cell Growth & Differentiation, 2:95-105. 113. V. Manne, C. Meyers and M. Barbacid. (1991). Farnesyl-Protein Transferase: A Potential Target for Inhibitors of Neoplastic Transformation Induced by ras Oncogenes.

10

In The Molecular Basis of Cancer (J.C. Lacal and M. Barbacid, eds.) Farmaindustria (Madrid, Spain), pp. 27-50. 114. M. Barbacid, F. Lamballe, D. Pulido, and R. Klein. (1991). The trk Family of Tyrosine Protein Kinase Receptors. BBA Reviews on Cancer, 1072:115-127. 115. R. Klein, S. Jing, V. Nanduri, E. O'Rourke and M. Barbacid. (1991). The trk Proto-Oncogene Encodes a Receptor for Nerve Growth Factor. Cell, 65:189-197. 116. C. Cordon-Cardo, P. Tapley, S. Jing, V. Nanduri, E. O'Rourke, F. Lamballe, K. Kovary, R. Klein, K.R. Jones, L.F. Reichardt and M. Barbacid. (1991). The trk Tyrosine Protein Kinase Mediates the Mitogenic Properties of Nerve Growth Factor and Neurotrophin-3. Cell, 66:173-183. 117. R. Klein, V. Nanduri, S. Jing, F. Lamballe, P. Tapley, S. Bryant, C. Cordon-Cardo, K.R. Jones, L.F. Reichardt and M. Barbacid. (1991). The trkB Tyrosine Protein Kinase is a Receptor for Brain-Derived Neurotrophic Factor and Neurotrophin-3. Cell, 66:395-403. 118. F. Lamballe, R. Klein and M. Barbacid. (1991). trkC, a New Member of the trk Family of Tyrosine Kinases is a Receptor for Neurotrophin-3. Cell, 66:967-979. 119. D. Pulido, S. Campuzano, T. Koda, J. Modolell and M. Barbacid. (1992). Dtrk, a Drosophila Gene Related to the trk Family of Neurotrophin Receptors, Encodes a Novel Class of Neural Cell Adhesion Molecule. EMBO J., 11:391-404. 120. X.R. Bustelo, J.A. Ledbetter and M. Barbacid. (1992). Product of vav Proto-Oncogene Defines a Novel Class of Tyrosine Protein Kinase Substrates. Nature, 356:68-71. 121. M. Barbacid. (1992). Human Oncogenes: Activation of ras and trk Oncogenes in Human Tumors. Proceedings of the 1991 Yakult International Symposium on "Molecular Basis of Carcinogenesis", pp 7-28. 122. F. Lamballe, R. Klein and M. Barbacid. (1992). The trk Family of Oncogenes and Neurotrophin Receptors. In “Multistage Carcinogenesis” (Proceedings of the 22nd International Symposium of the Princess Takamatsu Cancer Research Fund, Harris et al., eds) pp. 153-170. 123. P. Tapley, F. Lamballe and M. Barbacid. (1992). K252a is a Selective Inhibitor of the Tyrosine Protein Kinase Activity of the trk Family of Oncogenes and Neurotrophin Receptors. Oncogene, 7:371-381. 124. R. Klein, F. Lamballe, S. Bryant and M. Barbacid. (1992). The trkB Tyrosine Protein Kinase is a Receptor for Neurotrophin-4. Neuron, 8:947-956. 125. X.R. Bustelo and M. Barbacid. (1992). Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells. Science, 256:1196-1199.

11

126. W.C. Liu, M. Barbacid, M. Bulgar, J.M. Clark, A.R. Crosswell, L. Dean, T.W. Doyle, P.B. Fernandes, S. Huang, V. Manne, D.M. Pirnik, J.S. Wells and E. Meyers (1992). 10'Desmethoxystreptonigrin, a Novel Analog of Streptonigrin. J. Antibiotics, 45:454-457. 127. M. Alai, A.L.F. Mui, R.L. Cutler, X.R. Bustelo, M. Barbacid and G. Krystal (1992). Steel Factor Stimulates the Tyrosine Phosphorylation of the Proto-Oncogene Product, p95vav, in Human Hemopoietic Cells. J. Biol. Chem., 267:18021-18025. 128. S. Jing, P. Tapley and M. Barbacid. (1992). Nerve Growth Factor Mediates Signal Transduction Through Trk Homodimer Receptors. Neuron, 9:1067-1079. 129. M. Barbacid. (1993). The Trk Family of Neurotrophin Receptors: Molecular Characterization and Oncogenic Activation in Human Tumors. In Molecular Genetics of Nervous System Tumors (A.J. Levine and H.H. Schmidek, eds.), Wiley & Sons, Inc. (New York), Chapter 9, pp. 123-135. 130. N.Y. Ip, T.N. Stitt, P. Tapley, R. Klein, D.J. Glass, J. Fandl, L.A. Greene, M. Barbacid and G.D. Yancopoulos. (1993). Similarities and Differences in the Way Neurotrophins Interact with the Trk Receptors in Neuronal and Nonneuronal Cells. Neuron, 10:137-149. 131. X.R. Bustelo and M. Barbacid. (1993). The vav Proto-Oncogene: A Novel Hematopoietic Signal Transducer. In The Molecular Bases of Cancer (J.C. Lacal, ed.) Farmaindustria (Madrid, Spain), Vol. 28, pp. 447-465. 132. H.N. Marsh, W.K. Scholz, F. Lamballe, R. Klein, V. Nanduri, M. Barbacid and H.C. Palfrey. (1993). Signal Transduction Events Mediated by the BDNF Receptor gp145trkB in Primary Hippocampal Pyramidal Cell Culture. J Neurosci., 13: 4281-4292. 133. T.L. Steininger, B.H. Wainer, F.R. Klein, M. Barbacid and H.C. Palfrey. (1993). High-affinity nerve growth factor receptor (Trk) immunoreativity is localized in cholinergic neurons of the basal forebrain and striatum in adult rat brain. Brain Research, 612: 330-335. 134. X.R. Bustelo, S.D. Rubin, K.-L. Suen, D. Carrasco and M. Barbacid. (1993). Developmental Expression of the vav Proto-Oncogene. Cell Growth & Diff., 4: 297-308. 135. K. D. Beck, E. Schauwecker, F. Lamballe, R. Klein, M. Barbacid, T. H. McNeill, C. E. Finch, F. Hefti and J. R. Day. (1993). Induction of Non-Catalytic TrkB Neurotrophin Receptors in Hippocampal Glial Cells during Injury-Induced Axonal Sprouting. J Neurosci., 13: 4001-4014. 136. F.L. Lamballe, P. Tapley and M. Barbacid. (1993). trkC Encodes Multiple Neurotrophin-3 Receptors With Distinct Biological Properties And Substrate Specificities. EMBO J., 12: 3083-3094.

12

137. M. Barbacid. (1993). Nerve Growth Factor: a Tale of Two Receptors. Oncogene, 8: 2033-2042. 138. K.L. Suen, X.R. Bustelo, T. Pawson and M. Barbacid. (1993). Molecular Cloning of the Mouse grb2 Gene: Differential Interaction of the Grb2 Adaptor Protein with Epidermal Growth Factor and Nerve Growth Factor Receptors Mol. Cell. Biol., 13: 5500-5512. 139. R. Klein, R.J. Smeyne, W. Wurst, L.K. Long, B. A. Auerbach, A.L. Joyner and M. Barbacid. (1993). Targeted Disruption of the trkB Neurotrophin Receptor Gene Results in Nervous System Lesions and Neonatal Death. Cell, 75: 113-122. 140. F.L. Lamballe, R.J. Smeyne and M. Barbacid. (1994). TrkC, the Neurotrophin-3 Receptor, is Expressed in the Developing Central, Peripheral and Enteric Branches of the Mammalian Nervous System. J Neurosci., 14: 14-28. 141. X. Zhu, K.L. Suen, M. Barbacid, J.B. Bolen and J. Fargnoli. (1994). Interleukin-2 Induced Tyrosine Phosphorylation of Shc proteins Correlates with Factor Dependent T Cell Proliferation. J. Biol. Chem., 269: 5518-5522. 142. M. Barbacid. (1994). TrkA. In "The Protein Kinase Factsbook” Vol. II: Protein-Tyrosine Kinases, (D.G. Hardie and S. Hanks, eds.), Academic Press Ltd. (London) pp. 208-210. 143. M. Barbacid. (1994). TrkB. In "The Protein Kinase Factsbook” Vol. II: Protein-Tyrosine Kinases, (D.G. Hardie and S. Hanks, eds.), Academic Press Ltd. (London) pp. 211-213. 144. M. Barbacid. (1994). TrkC. In "The Protein Kinase Factsbook” Vol. II: Protein-Tyrosine Kinases, (D.G. Hardie and S. Hanks, eds.), Academic Press Ltd. (London) pp. 214-217. 145. M. Barbacid. (1994). DmTrk. In "The Protein Kinase Factsbook” Vol. II: Protein-Tyrosine Kinases, (D.G. Hardie and S. Hanks, eds.), Academic Press Ltd. (London) pp. 230-232. 146. M. Sanchez, P. Tapley, S.S. Saini, B. He and M. Barbacid. (1994). Tyrosine Protein Kinases in Rat Embryonic Hippocampal Neurons: Identification of Ptk-3, a Novel Tyrosine Kinase Receptor. Proc. Natl. Acad. Sci. U.S.A., 91: 1819-1823. 147. M.G. Kazanietz, X.G. Bustelo, M. Barbacid, W. Kolch, H. Mischak, G. Wong and P. Blumberg. (1994). Zinc Finger Domains and Phorbol Ester Pharmacophore: Analysis of Binding to a Mutated Form of Protein Kinase C Zeta and the Vav and c-Raf Proto-oncogene Products. J. Biol. Chem., 269: 11590-11594. 148. X.R. Bustelo, K.L. Suen, K. Leftheris, C.A. Meyers and M. Barbacid. (1994). Vav Cooperates with Ras to Transform Rodent Fibroblasts but is not a Ras GDP/GTP Exchange Factor. Oncogene, 9: 2405-2413.

13

149. M. Barbacid. (1994). The Trk Family of Neurotrophin Receptors. J. of Neurobiology, 25: 1386-1403. 150. R. Klein, I. Silos-Santiago, R.J. Smeyne, S. Lira, R. Brambrilla, S. Bryant, L. Zhang, W.D. Snider and M. Barbacid. (1994). Disruption of the Neurotrophin-3 Receptor Gene trkC Eliminates Ia Muscle Afferents and Results in Abnormal Movements. Nature, 368: 249-251. 151. Z. Songyang, S.E. Shoelson, J. McGlade, P. Olivier, T. Pawson, R.X. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi, R. Ren, D. Baltimore, S. Ratnofsky, R.A. Feldman and L. C. Cantley. (1994). Specific Motifs Recognized by the SH2 Domains of Csk, 3BP2, fps/fes, GRB-2, SHPTP1, SHC, Syk and Vav. Mol. Cell Biol., 14: 2777-2785. 152. R.J. Smeyne, R. Klein, A. Schnapp, L.K. Long, S. Bryant, A. Lewin, S.A. Lira, and M. Barbacid. (1994). Severe Sensory and Sympathetic Neuropathies in Mice carrying a Disrupted Trk/NGF Receptor Gene. Nature, 368: 246-249. 153. A. Chalazonitis, T.P. Rothman, J. Chen, F. Lamballe, M. Barbacid, and D. Gershon. (1994). Neurotrophin-3 Induces Neural Crest-Derived Cells From Fetal Rat Gut To Develop In Vitro As Neurons or Glia. J. Neurosci., 14: 6571-6584. 154. M. Wittekind, C. Mapelli, B.T. Farmer II, V. Goldfarb, T. Lavoie, J. Tsao, K-L. Suen, M. Barbacid, C.A. Meyers, and L. Mueller. (1995). Orientation of Peptide Fragments from Sos Proteins Bound to the N-termainal SH3 Domain of Grb2 Determined by NMR Spectroscopy. Biochemistry, 33: 13531-13539. 155. M. Barbacid. (1995). Life and Death in Mice without Trk Neurotrophin Receptors. In “Life and Death in the Nervous System” (C.F. Ibañez et al., eds.), Pergamon Press, pp.345-360. 156. A. Zmuidzinas, K-D Fischer, S.A. Lira, K. Forrester, S. Bryant, A. Bernstein and M. Barbacid. (1995). The Vav Proto-Oncogene is Required Early in Embryogenesis but not for Hematopoietic Development In Vitro. EMBO J., 14:1-11. 157. X.R. Bustelo, K-L Suen, G. Dreyfuss and M. Barbacid. (1995). Association of the vav Proto-Oncogene Product with Poly(rC)-Specific RNA Binding Proteins. Mol. Cell. Biol., 15, 1324-1332. 158. V. Manne, N. Yan, J.M. Carboni, A.V. Tuomari, C.S. Ricca, J. Gullo-Brown, M.L. Andahazy, R.J. Schmidt, D. Patel, R. Zahler, C.J. Der, A.D. Cox, R. Weinmann, J.T. Hunt, E.M. Gordon, M. Barbacid, B.R. Seizinger. (1995). Bisubstrate Inhibitors of Farnesyltransferase: A Novel Class of Specific Inhibitors of Ras Transformed Cells. Oncogene, 10: 1763-1779. 159. I. Silos-Santiago, D.C. Molliver, S. Ozaki, R. Smeyne, A. Fagan, M. Barbacid and W.D. Snider. (1995). Non-TrkA-Expressing Small DRG Neurons are Lost in TrkA Deficient Mice. J. Neurosci., 15: 5929-5942.

14

160. J.M. Carboni, N. Yan, A.D. Cox, X. Bustelo, S. M. Graham, M.J. Lynch, R. Weinmann, B.R. Seizinger, C.J. Der, M. Barbacid and V. Manne. (1995). Farnesyltransferase Inhibitors are Inhibitors of RAS, but not R-RAS2/TC21, Transformation. Oncogene, 10: 1905-1913. 161. K.D. Fischer, S. Gardner, A. Zmuidzinas, M. Barbacid, A. Bernstein and C. Guidos. (1995). Defective T Cell Receptor Signaling and Positive Selection of Vav-Deficient CD4+CD8 Thymocytes. Nature, 374: 474-477. 162. K.L. Suen, X.R. Bustelo and M. Barbacid. Lack of Evidence for the Activation of the Ras/Raf Mitogenic Pathway by 14-3-3 Proteins in Mammalian Cells. (1995). Oncogene, 11: 825-831. 163. M. Barbacid. Structural and Functional Properties of the Trk Family of Neurotrophin Receptors. (1995). In “Receptor Activation by Antigens, Cytokines, Hormones and Growth Factors” (D. Naor, P. De Meyts, M. Feldmann and J. Schlessinger, eds.). Annals of the New York Academy of Science, 766: 442-458. 164. M. Barbacid. Neurotrophic Factors and their Receptors. (1995). Curr. Opin. Cell Biol., 7: 148-155. 165. C. Shou, A. Wurmser, K.L. Suen, M. Barbacid and L.A. Feig. (1995). Differential Response of the Ras Exchange Factor RasGRF to Tyrosine Kinase and G Protein Mediated Signals. Oncogene,10: 1887-1893. 166. D.V. Patel, E.M. Gordon, R.J. Schmidt, H.N. Weller, M.G. Young, R. Zahler, M. Barbacid, et al. (1995). Phosphinyl acid-based Bisustrate Analog Inhibitors of Ras Farnesyl Protein Transferase. J. Med. Chem., 38: 435-442. 167. M. Barbacid. NGF Receptors. (1996). In “Growth Factors and Cytokines in Health and Disease” (D. LeRoith and C. Bondy,eds.) JAI Press, pp 257-275. 168. B. Fritzsch, I. Silos-Santiago, R. Smeyne, A.M. Fagan and M. Barbacid. (1995). Reduction and loss of inner ear innervation in trkB and trkC receptor knock out mice. Auditory Neurosci., 1: 401-417. 169. A. Fagan, H. Zhang, S. Landis, R.J. Smeyne, I. Silos-Santiago and M. Barbacid. (1996). TrkA, but not TrkC Receptors are Required for Survival of Sympathetic Neurons in vivo. J. Neurosciesce, 16: 6208-6218. 170. M. Lopez-Barahona, X.R. Bustelo and M. Barbacid. (1996). The TC21 Oncoprotein interacts with the Ral Guanidine Nucleotide Dissociation Factor. Oncogene, (1996) 12: 463-470. 171. J. L. Rosa, R.P. Casaroli-Marano, A.J. Buckler, S. Vilaro and M. Barbacid. (1996). P619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. EMBO J.,15: 4262-4273.

15

172. F.A. White, I. Silos-Santiago, D.C. Molliver, M. Nishimura, H. Phillips, M. Barbacid and W.D. Snider. (1996). Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia. J. Neuroscience, 16: 4662-4672. 173. K. Leftheris, T. Kline, G.D. Vite, Y.H. Cho, R.S. Bhide, D.V. Patel, M.M. Patel, R.J. Schmidt, H.N. Weller, M.L. Andahazy, J.M. Carboni, J.L. Gullo-Brown, F.Y.F. Lee, C. Ricca, W.C. Rose, N. Yan, M. Barbacid, J.T. Hunt, C.A. Meyers, B.R. Seizinger, R. Zahler and V. Manne. (1996) Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular and in Vivo Activity. J. Med. Chem., 39, 224-236. 174. K.E. Schuebel, X.R. Bustelo, D.A. Nielsen, B.J. Song and M. Barbacid, D. Goldman and I.J. Lee. (1996). Isolation and Characterization of Murine vav-2, a Member of the vav Family of Proto-oncogenes. Oncogene, 13: 363-371. 175. M. Sanchez, I. Silos-Santiago, J. Frisen, B. He, S. Lira and M. Barbacid. (1996). Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature, 382: 70-73. 176. P. Crespo, X. R.Bustelo, D.S. Aaronson, O.A. Coso, M. Lopez-Barahona, M. Barbacid and J.S. Gutkind. (1996). Rac-1 Dependent Stimulation of the JNK/SAPK Signaling Pathway by Vav. Oncogene, 13: 455-460. 177. J.T. Erickson, J.C. Conover, J. Champagnat, V. Borday, R.J. Smeyne, T.M. DeChiara, M. Barbacid, G.D. Yancopoulos and D.M. Katz. (1996). Mice Lacking Brain-Derived Neurotrophic Factor Exhibit Visceral Sensory Neuron Losses Distinct from Mice Lacking NT4 and Display a Severe Developmental Deficit in Control of Breathing. J. Neuroscience, 16: 5361-5371. 178. S. Park, J. Frisen and M. Barbacid. (1997). Aberrant Axonal Projections in Mice lacking EphA8/Eek Tyrosine Protein Kinase Receptors. EMBO J., 16: 3106-3114. 179. I. Silos-Santiago, A.M. Fagan, M. Garber, B. Fritzsch, M. Barbacid. (1997). Severe Sensory Deficits But Normal CNS Development In Newborn Mice Lacking TrkB and TrkC Tyrosine Kinase Receptors. Eur. J. Neuroscience, 9: 2045-2056. 180. S. Alcantara, J. Frisen, J. A. del Rio, E. Soriano, M. Barbacid and I. Silos-Santiago. (1997). TrkB Signaling is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death. J. Neuroscience, 17: 3623-3633. 181. J. L. Rosa and M. Barbacid. (1997). A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. Oncogene, 15: 1-6. 182. Y. Yan, J. Frisen, M. Lee, J. Massagué and M. Barbacid. (1997). Ablation of the Cdk inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes & Dev., 11: 973-983.

16

183. B. Fritzsch, P.A. Sarai, M. Barbacid and I. Silos-Santiago. (1997). Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds. Int. J. Dev. Neuroscience, 15: 563-576. 184. X.R. Bustelo, P. Crespo, M. Lopez-Barahona, J.S. Gutkind and M. Barbacid. (1997). Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene, 15: 2511-2520. 185. J. Frisen, M. Barbacid. (1997). Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system. Cell Tissue Res., 290: 209-215. 186. M. Barbacid. (1997). Genetic analysis of the role of the Trk and Eph families of tyrosine protein kinase receptors in the development of the mammalian nervous system. In “Kinases and Phosphatases in Lymphocyte and Neuronal Signaling” (H. Yakura, ed.) Springer-Verlag, in press. 187. B.T. Fundin, I. Silos-Santiago, P. Ernfors, A.M. Fagan, H. Aldskogius, T.M. de Chiara, H.S. Philips, M. Barbacid, G.D. Yancopoulos and F.L. Rice. (1997). Differential dependency of cutaneous mechanoreceptors on neurotrophins, Trk receptors and p75 LNGFR. Dev. Biol., 190: 94-116. 188. A. Fagan, M. Garber, M. Barbacid, I. Silos-Santiago and D.M. Holtzman. (1997). A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J. Neuroscience, 17: 7644-7654. 189. J. Frisén, P.A. Yates, T. McLaughlin, G.C. Friedman, D.D.M. O’Leary and M. Barbacid. (1998). Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron, 20: 235-243. 190. A. Martínez, S. Alcántara, V. Borrell, J. A. Del Río, J. Blasi, R. Otal, N. Campos, A. Boronat, M. Barbacid, I. Silos- Santiago and E. Soriano. (1998). TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections. J. Neuroscience, 18:7336-7350. 191. D.A. Feldheim, P. Vanderhaeghen, M.J. Hansen, J. Frisén, Q. Lu, M. Barbacid and J.G. Flanagan. (1998). Topographic guidance labels in a sensory projection to the forebrain. Neuron, 21:1303-1313. 192. B. Fritzsch, M. Barbacid and I. Silos-Santiago. (1998). Nerve dependency of developing and mature sensory receptor cells. Ann N Y Acad Sci., 855:14-27. 193. B. Fritzsch, M. Barbacid and I. Silos-Santiago. (1998). The combined effects of trkB and trkC mutations on the innervation of the inner ear. Int J Dev Neurosci., 16: 493-505. 194. F. de Castro, I. Silos-Santiago, M. Lopez de Armentia, M. Barbacid and C. Belmonte. (1998). Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice. Eur J Neurosci., 10:146-152.

17

195. F.L. Rice, K.M. Albers, B.M. Davis, I. Silos-Santiago, G.A. Wilkinson, A.M. LeMaster, P. Ernfors, R.J. Smeyne, H. Aldskogius, H.S. Phillips, M. Barbacid, T.M. DeChiara, G.D. Yancopoulos, C.E. Dunne and B.T. Fundin. (1998). Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev. Biol., 198: 57-81. 196. K.D. Fischer, Y.Y. Kong, H. Nishina, K. Tedford, L.E. Marengere, I. Kozieradzki, T. Sasaki, M. Starr, G. Chan, S. Gardener, M.P. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein and J.M. Penninger. (1998). Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol., 8: 554-562. 197. S.G. Rane, P. Dubus, R.V. Mettus, E.J. Galbreath, G. Boden, E. P. Reddy and M. Barbacid. (1999). Loss of Cyclin-Dependent Kinase 4 Expression Causes Infertility and Insulin-Deficient Diabetes while its Activation Results in Pancreatic Islet Hyperplasia. Nature Genetics, 22: 44-52. 198. J. Frisen, J. Holmberg, M. Barbacid (1999). Ephrins and Eph receptors: Multitalented directors of embryonic development. EMBO J., 18: 5159-5165. 199. D.A. Feldheim, Y.-I. Kim, A.D. Bergemann, J. Frisén, M. Barbacid and J.G. Flanagan. (2000). Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron, 25: 563-574. 200. E. Latres, M. Malumbres, R. Sotillo, J. Martín, S. Ortega, J. Martín-Caballero, J.M. Flores, C. Cordón-Cardo and M. Barbacid. (2000). Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis. EMBO J., 19: 3496-3506. 201. M. Malumbres, S. Ortega and M. Barbacid. (2000). Genetic Analysis of Mammalian Cyclin-Dependent Kinases and Their Inhibitors. Biological Chemistry, 381: 827-838.. 202. S. Matsuo, H. Ichikawa, T.A. Henderson, I. Silos-Santiago, M. Barbacid, J.J. Arends, M.F. Jacquin. (2001). TrkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice. Neuroscience, 105: 747-760, 2001. 203. F. Zindy, W. den Besten, B.Chen, J. E. Rehg, E. Latres, M. Barbacid, J. Pollard, C. J. Sherr, P. E. Cohen and M. F. Roussel. (2001). Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors P18INK4c and P19INK4d. Mol. Cell. Biol., 21: 3244-3255. 204. K. Tedford, L. Nitschke, I. Girkontaite, A. Charlesworth, G. Chan, V. Sakk, M. Barbacid and K.-D. Fischer (2001). Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat. Immunology, 2: 548-555. News & Views commentary in pgs. 482-484. 205. R. Sotillo, P. Dubus, J. Martín, E. de la Cueva, S. Ortega, M. Malumbres and M. Barbacid. (2001). Wide spectrum of tumors in knock in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J., 20: 6637-6647.

18

206. R. Sotillo, J.F. García, S. Ortega, J. Martín, P. Dubus, M. Barbacid and M. Malumbres. (2001). Invasive melanoma in Cdk4-targeted mice. Proc. Natl. Acad. Sci. U.S.A., 98: 13312-13317. 207. M. Malumbres and M. Barbacid. (2001). To cycle or not to cycle: A critical decision in cancer. Nature Rev. Cancer, 1:222-231. 208. S. Ortega, M. Malumbres and M. Barbacid. (2002). Cdk4, INK4 Inhibitors and Cancer. BBA Reviews on Cancer, 1602:73-87. 209. S. Ortega, M. Malumbres and M. Barbacid. (2002). Cell Cycle and Cancer: G1 Checkpoints and G1/S Transition. Current Genomics, 3: 245-263. 210. J. Martín, S.L. Hunt, P. Dubus, R. Sotillo, F. Néhmé-Pélluard, M.A. Magnuson, A.F. Parlow, M. Malumbres, S. Ortega and M. Barbacid. (2003). Genetic rescue of Cdk4 null mice restores pancreatic ß-cell proliferation but not homeostatic cell number. Oncogene, 22:5261-5269. 211. M. Malumbres and M. Barbacid. (2003). RAS oncogenes: the first 30 years. Nature Rev. Cancer, 3:459-465. 212. Guerra, N. Mijimolle, A. Dhawahir, P. Dubus, M. Barradas, M. Serrano, V. Campuzano and M. Barbacid. (2003). Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell, 4:111-120. 213. S. Ortega, I. Prieto, J. Odajima, A. Martín, P. Dubus, R. Sotillo, J.L. Barbero, M. Malumbres and M. Barbacid. (2003). Cyclin dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genetics, 35:25-31.

News & Views commentaries for this article appeared in: – J.M. Roberts and C.J. Sherr (2003). Bared essentials of CDK2 and cyclin E. Nat. Genetics – J. Méndez (2003). Cell proliferation without cyclinE-CDK2. Cell, 114:398-399. – A.B. Gladden and J. A. Diehl. (2003). Cell cycle progression without cyclin E/CDK2: breaking down the wall of dogma. Cancer Cell, 4:160-162.

214. M. Malumbres, S.L. Hunt, R. Sotillo, J. Martín, J. Odajima, A. Martín, P. Dubus, S. Ortega and M. Barbacid. (2003). Driving the cell cycle to cancer. Adv Exp Med Biol., 532:1-11. 215. N. Marzo, C. Mora, M.E. Fabregat, J. Martin, E.F. Usac, C. Franco, M. Barbacid and R. Gomis. (2004). Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes. Diabetologia, 47: 686-694. 216. M. Malumbres, R. Sotillo, D. Santamaría, J. Galán, A. Cerezo, S. Ortega, P. Dubus and M. Barbacid. (2004). Mammalian Cells Cycle without the D-type Cyclin-Dependent Kinases Cdk4 and Cdk6. Cell, 118: 493-504.

News & Views commentaries for this article appeared in:

19

– M. Pagano M and P.K. Jackson (2004). Wagging the dogma; tissue-specific cell cycle control in the mouse embryo. Cell, 118:535-538.

– C.J. Sherr and J.M. Roberts (2004). Living with or without cyclins and cyclin-dependent kinases. Genes Dev., 18:2699-2711.

– C. Holding. The Scientist, Aug 20, 2004. 217. J. Auwerx, P. Avner, R. Baldock, A. Ballabio, R. Balling, M. Barbacid, A. Berns, A. Bradley, S. Brown, P. Carmeliet, P. Chambon, R. Cox, D. Davidson, K. Davies, D. Duboule, J. Forejt, F. Granucci, N. Hastie, M. Hrabé de Angelis, I. Jackson, D. Kioussis, G. Kollias, M. Lathrop, U. Lendahl, M. Malumbres, H. von Melchner, W. Müller, J. Partanen, P. Ricciardi-Castagnoli, P. Rigby, B. Rosen, N. Rosenthal, B. Skarnes, A.F. Stewart, J. Thornton, G. Tocchini-Valentini, E. Wagner, W. Wahli and W. Wurst. (2004). The European dimension for the mouse genome mutagenesis programme. Nat. Genetics, 36: 395-397. 218. N. Mijimolle, J. Velasco, P. Dubus, C. Guerra, C.A. Weinbaum, P.J. Casey, V. Campuzano and M. Barbacid (2005). Protein Farnesyltransferase in Embryogenesis, Adult Homeostasis and Tumor Development. Cancer Cell, 7:313-324.

News & Views commentaries for this article appeared in: – S.M. Sebti (2005). Protein farnesylation: Implications for normal physiology,

malignant transformation, and cancer therapy. Cancer Cell, 7:297-300. 219. R. Sotillo, O. Renner, P. Dubus, J. Ruiz-Cabello, J. Martín-Caballero, M. Barbacid, A. Carnero, and Marcos Malumbres (2005). Cooperation Between Cdk4 and p27Kip1 in Tumor Development: a Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. Cancer Res., 65: 3846-3852. 220. A. Martín, J. Odajima, D. Santamaría, S.L. Hunt, P. Dubus, S. Ortega, M. Malumbres and M. Barbacid. (2005). Cell Cycle Inhibition and Tumor Suppression by p21Cip1 and p27Kip1 are Independent of Cdk2. Cancer Cell, 7: 591-598. 221. M. Collado, J. Gil, A. Efeyan, C. Guerra, A.J. Schuhmacher, M. Barradas, A. Benguría, A. Ceballos, J.M. Flores, M. Barbacid, D. Beach and M. Serrano (2005) Identification of a senescent phase in tumour progression. Nature, 436:642.

News & Views commentaries for this article appeared in: N.E. Sharpless and R.A. DePinho (2005). Crime and punishment. Nature, 436:636-637.

222. M. Malumbres and M. Barbacid. (2005). Mammalian Cyclin-dependent Kinases. Trends in Biochem Sci., 30:630-641. 223. Abella, P. Dubus, M. Malumbres, S.G. Rane, H. Kiyokawa , F. Vignon, D. Langin, M. Barbacid, and L. Fajas. (2005). Cdk4 promotes adipogenesis through PPARg activation. Cell Metabolism, 2:239-249. 224. M. Barbacid, S. Ortega, R. Sotillo, J. Odajima, A. Martín, D. Santamaría, P. Dubus and M. Malumbres. (2005).Cell Cycle and Cancer: Genetic Analysis of the Role of Cyclin Dependent Kinases. Cold Spring Harb Symp Quant Biol., 70:233-240.

20

225. Duensing, M. Tseng, Y. Liu, M. Malumbres, M. Barbacid and S. Duensing (2006) Cyclin-dependent kinase 2 is dispensable for normal centrosome homeostasis but mediates centrosome overduplication induced by a viral oncogene. Oncogene, 25: 2943-2949. 226. J. Steitz, S. Büchs, D. Tormo, A. Ferrer, J. Wenzel, C. Huber, T. Wölfel, M. Barbacid, M. Malumbres and T. Tüting. (2006). Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int. Journal Cancer, 118:373-380. 227. M. Malumbres and M.Barbacid. (2006). Is cyclin D1-CDK4 kinase a bona fide cancer target?. Cancer Cell, 9:2-4. 228. E. Hacker, H.K. Muller, N. Irwin, B. Gabrielli, S. Pavey, M.B. Powell, M. Malumbres, M. Barbacid, N. Hayward and G. Walker. (2006). Spontaneous and UVR-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Research, 66:2946-2952. 229. D. Tormo, A. Ferrer, E. Gaffal, J. Wenzel, E. Basner-Tschakarjan, J. Steitz, L.C. Heukamp, I. Gütgemann, R. Buettner, M. Malumbres, M. Barbacid, G. Merlino and T. Tüting. (2006). Rapid growth of invasive metastatic melanoma in carcinogen-treated HGF/SF-transgenic mice carrying an oncogenic CDK4 mutation. Am. J. Pathol., 169:665-672. 230. O.J. Sansom, V. Meniel, J.A. Wilkins, A. Cole, K.A. Oien, T. Jamieson, C. Guerra, G.H. Ashton, M. Barbacid, A.R. Clarke. (2006). Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc. Natl. Acad. Sci. U.S.A., 103:14122-14127. 231. M. Malumbres and M. Barbacid. (2007). Cell cycle kinases in cancer. Current Opinion in Genetics & Development, 17: 60-65. 232. C. Guerra, A.J. Schuhmacher, M. Cañamero, P.J. Grippo, L. Verdaguer., L. Pérez-Gallego, P. Dubus, E.P. Sandgren and M. Barbacid. (2007). Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell, 11: 291-302.

News & Views commentaries for this article appeared in: L.C. Murtaugh and S.D. Leach. (2007). A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers. Cancer Cell. 11: 211-213.

233. C. Barrière, D. Santamaría, A. Cerqueira, J. Galán, A. Martín, S. Ortega, M. Malumbres, P. Dubus and M. Barbacid. (2007). Mice thrive without Cdk4 and Cdk2. Mol. Oncology, 1: 72-83. 234. J.J. Ventura, S. Tenbaum, E. Perdiguero, C. Guerra, M. Barbacid, M. Pasparakis and A.R. Nebreda. (2007). Essential role of p38α MAP kinase in lung stem/progenitor cell proliferation and differentiation. Nat. Genetics, 39: 750-758. 235. M. Barbacid. (2007). Returning home. Cell, 129: 641-644.

21

236. D. Santamaría, C. Barrière, A. Cerqueira, S. Hunt, C. Tardy., K. Newton., J.F. Cáceres., P. Dubus., M. Malumbres. and M. Barbacid. (2007). Cdk1 is sufficient to drive the mammalian cell cycle. Nature, 448: 811-815.

News & Views commentaries for this article appeared in: M. Leslie. (2007). For cdks, one is enough. J Cell Biology, 178:892. A. Blewett. (2007). CDK1 in the driving seat. Nat. Rev. Mol. Cell Biol., in press. This paper has been selected for Faculty of 1000 Biology

237. M. Malumbres, P. Pevarello, M. Barbacid and J.R. Bischoff. (2008). CDK inhibitors in cancer therapy: What is next?. Trends in Pharmacol. Sci., 29: 16-21. 238. S. Atanasoski, M. Boenter, L. De Ventura, H. Pohl, K. Beier P. Young, M. Barbacid and U. Suter. (2008). Postnatal Schwann Cell Proliferation But Not Myelination is Strictly and Uniquely Dependent on Cyclin-Dependent Kinase 4. Mol Cell Neurosci., 37: 519-527. 239. A.J. Schuhmacher, C. Guerra, V. Sauzeau, M. Cañamero, X.R. Bustelo and M. Barbacid. (2008). A mouse model for Costello syndrome unveils an angiotensin II-mediated hypertensive condition. J Clinical Investigation, 118: 2169-2179. 240. P. Boyle, B.O. Anderson, L.C. Andersson, Y. Ariyaratne, G.R. Auleley, M. Barbacid, H. Bartelink, J. Baselga, K. Behbehani, F. Belardelli, A. Berns, J. Bishop, O. Brawley, H. Burns, M. Clanton, B. Cox, D. Currow, J.M. Dangou, D. de Valeriola, K. Dinshaw, A. Eggermont, J. Fitzpatrick, M. Forstmane, E. Garaci, A.T. Gavin, T. Kakizoe, M. Kasler, N. Keita, D. Kerr, D. Khayat, S. Khleif, T. Khuhaprema, T. Knezevic, R. Kubinova, M. Mallath, J.M. Martin-Moreno, D. McCance, J.G. McVie, A. Merriman, T. Ngoma, M. Nowacki, J. Orgelbrand, J.G. Park, M. Pierotti, L.P. Ashton, P. Puska, C.V. Escobar, B. Rajan, T. Rajkumar, U. Ringborg, C. Robertson, A. Rodger, L. Roovali, L.A. Santini, M. Sarhan, J. Seffrin, V. Semiglazov, B.M. Shrestha , K.C. Soo, V. Stamenic, C. Tamblyn, R. Thomas, M. Tuncer, T. Tursz, R. Vaitkiene, C. Vallejos, U. Veronesi, A. Wojtyla, D. Yach, K.Y. Yoo, W. Zatonski, D. Zaridze, Y.X. Zeng, P. Zhao and T. Zheng. (2008). Need for global action for cancer control. Ann Oncol., 19:1519-1521. 241. M. Malumbres and M. Barbacid (2009). Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer, 9: 153-166. 242. J. Urosevic, E.Y. Sum, V. Moneo, M. Drosten, A. Dhawahir, M. Becerra, A. Carnero and M. Barbacid. (2009). Using cells devoid of RAS proteins as tools for drug discovery. Mol. Carcinogenesis, 48: 1038-1047. 243. C. Martínez-Romero, I. Rooman, A. Skoudy, C. Guerra, X. Molero, A. González, M. Iglesias, T. Lobato, A. Bosch, M. Barbacid, F.X. Real and I. Hernández-Muñoz. (2009). The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. J Pathology, 219: 205-213. 244. A. Cerqueira, D. Santamaría, B. Martínez-Pastor, M. Cuadrado, O. Fernández-Capetillo and M. Barbacid. (2009). Overall Cdk activity modulates the DNA damage response in mammalian cells. J. Cell Biol., 187: 773-780.

22

245. S. Campaner, M. Doni, P. Hydbring, A. Verrecchia, L. Bianchi, D. Sardella, T. Schleker, D. Perna, S. Tronnersjö, M. Murga, O. Fernandez-Capetillo, M. Barbacid, L.G. Larsson and B. Amati. (2010). Cdk2 suppresses cellular senescence induced by the myc oncogene. Nat. Cell Biol., 12: 54-60.

News & Views commentaries for this article appeared in: M. Serrano. (2010). A lower bar for senescence. Nature, 464:363-364.

246. M. Drosten, A. Dhawahir, E.Y.M. Sum, J. Urosevic, C.G. Lechuga, L.M. Esteban, E. Castellano, C. Guerra, E. Santos and M. Barbacid. (2010). Genetic analysis of Ras signaling pathways in cell proliferation, migration and survival. EMBO Journal, 29: 1091-1104.

This paper has been selected for Faculty of 1000 Biology 247. L. Matthias, A Bergström, T. Shimokawa, U. Tostar, Q. Jin, C. Guerra, M. Barbacid and R. Toftgård. (2010). DYRK1B-dependent shift of Hedgehog signaling from an autocrine towards a paracrine mode by mutant RAS. Nat. Struct. Mol. Biol., in press. 248. M. Puyol, A. Martín, P. Dubus, F. Mulero, P. Pizcueta, G. Khan, C. Guerra, D. Santamaría and M. Barbacid. (2010). A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategic for non small cell lung carcinoma. Submitted for publication. 249. D. Frezzetti, M. De Menna, P. Zoppoli, C. Guerra, A. Ferraro, A.M. Bello, P. De Luca, C. Calabrese, A. Fusco, M. Ceccarelli, M. Zollo, M. Barbacid, R. Di Lauro and G. De Vita,. (2010). Upregulation of miR-21 by Ras in vivo and its role in tumor growth. Submitted for publication.