„Marine Biotechnology: SME ´s in EuropeFocus: ScanBalt – the Baltic Sea Region ”www.scanbalt.org

Heinrich Cuypers, PhD, BioCon Valley Mecklenburg-Vo rpommern, Germany “Rendez-vous de Concarneau 2015 - Where Industry meets Science”, October 15th

Structure of Blue Biotechnology Sector

Source: EC Blue Biotechnology study

27.10.2015

Key Figures in Europe

Source : http://www.europabio.org/facts-about-biotech-europe

World Marine Biotechnology Industry

• Published: Feb 24, 2015 7:04 p.m. ET• NEW YORK, Feb. 24, 2015 /PRNewswire/ -- This report analyzes the worldwide

markets for Marine Biotechnology in US$ Million . The Global market is further analyzed by the following Product Segments: Marine Biomaterials, Marine Bioactive Substances, and Others. The Major End-Use Applications analyzed are Industrial Products, Health Care/Biotechnology, Consumer Products, Public Services & Infrastructure, and Others. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 84 companies including many key and niche players such as:

• Aker BioMarine AS (Norway), Aqua Bio Technology ASA (Norway), BASF SE (Germany), CP Kelco (US), Cyanotech Corp. (US), Nutrex Hawaii (US), FMC Health and Nutrition (US), NovaMatrix (Norway), GlycoMar Ltd. (UK), Jazz Pharmaceuticals plc (Ireland),Lonza Group Ltd. (Switzerland), Marinova Pty Ltd (Australia), New England Biolabs Inc (US), oceanBASIS GmbH (Germany), PharmaMar S.A (Spain), PML Applications Ltd. (UK), Prolume Ltd (US), BioLume®, Inc. (US), Royal DSM N.V (Netherlands), Sea Run Holdings, Inc. (US), SEPPIC (France), Biotech Marine (France), Tequesta BioVentures (US)

Source : http://www.marketwatch.com/story/world-marine-biotechnology-industry-2015-02-24

Key Figures in Bretagne, F

Biotech's weight in Bretagne's economy• 150 companies, including several leading firms (Yves Rocher, Group Roullier, Lactalis, Biotrial,

sanofi aventis, Guerbet, AES Chemunex, Medria, etc.)• 6000 staff in the biotech/life science industry• A dynamic SME environment and the creation of the Bretagne Biosciences business club• a cumulative turnover of about €400 million (estimation for 2010)Technical and academic resources• 63 academic research groups• 26 technological core facilities and innovation centres• 2 university medical centers (in Brest and Rennes)• 4 universities• 22 other higher education and research institutions• 7 research parks and clusters• Many national research institute labs (INSERM, CNRS, INRA, IFREMER, CEMAGREF, etc.)

Source : http://www.capbiotek.fr/index.php/en/biotechnologies-in-bretagne/key-figures

Drug development in Europe

Source : http://www.europabio.org/facts-about-biotech-europe

Networking national & international

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National :BioCon Valley is member of the German BioRegions;

www.biodeutschland.org/ak-bioregio.htmlwww.biotechnologie.de

International :BioCon Valley is cofounder of ScanBalt – the network of Life Science and health networks in Baltic Sea Region, i.e. Denmark, Estonia, Finland, Germany, Iceland, Latvia, Lithuania, Norway, Poland, Sweden, North-West Russia;

www.scanbalt.org

� Tasks:– Bundle and align regional interests and forcees in

life sciences and health (triple helix-model)– Stimulate cooperation between companies, research

& development and health care providers– Foster international marketing and collaboration

� Shareholders:– Federal State Mecklenburg-Vorpommern– BioCon Valley Mecklenburg-Vorpommern e.V.

(~160 members)– 4 financial institutions, 2 private shareholders

� 2 locations (Greifswald and Rostock)with presently 20+ employees

BioCon Valley ® GmbH– cluster management

© BioCon Valley® GmbH · Greifswald / Rostock 827.10.2015

27.10.2015 9

German BioRegions: hot spots for biotech industry since 1996

© BioCon Valley® GmbH · Greifswald / Rostock

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ScanBalt – Project Factory in BSR Since 2001

=BioCon Valley Partner

BlueBiotecAlliance(INTERREG BSR)

BlueBiotecAlliance(INTERREG BSR)

BlueBiotecAlliance(INTERREG BSR)

Road Map of Cross-Border Cooperation- Aquaculture and Marine Biotec

2011 20132012 20182010 2014

“SUBMARINER”(INTERREG BSR)

BMBF

INTERREG BSR Full proposal

Basic projects

2015 2016

InnoMarBio(INTERREG South Baltic)

InnoMarBio(INTERREG South Baltic)

InnoMarBio(INTERREG South Baltic)

INNOAQUATECH

INTERREG BSR Seed money

2017

27.10.2015 © BioCon Valley® GmbH · Greifswald / Rostock 11

BBA

A B C D E

INNOAQUATECH(INTERREG South Baltic)

INNOAQUATECH(INTERREG South Baltic)

INNOAQUATECH(INTERREG South Baltic)

INNOAQUATECH

Project SUBMARINERSustainable Uses of Baltic Marine Resources

• The Baltic Sea Region (BSR) faces enormous challenges including growing transport, new installations, fishery declines, severe marine pollution, excessive nutrient input, and the effects of climate change. But novel technologies and growing knowledge also provide opportunities for new uses of marine ecosystems, which should not only be valued for their commercial appeal but for their potentially significant contribution to solving its environmental problems: macroalgae cultivation, blue biotechnology , innovative fish and mussel mariculture solutions , and wave energy are among such new possible uses.

• The project is funded by the Baltic Sea Region Programme 2007-2013. It has a total budget of €3.6 million, of which €2.8 million are ERDF co-finance and €0.8 million are partners’ contributions. It runs from October 2010 to December 2013.

Project partner:• Maritime Institute in Gdańsk (Lead),German Ministry of Environment,KiWiZ at Geomar, University of

Rostock, BioCon Valley, Finnish Environment Institute, Klaipeda University Coastal Research & Planning Institute, Klaipeda Science & Techn. Park, Tallinn University of Technology, Entrepreneurship Development Centre for Biotechn. & Medicine, Latvian Ministry of Environment, Environmental Development Association, ScanBalt, Lolland Energy Holding, Royal Institute of Technology, Royal Swedish Acad. of Sciences, Trelleborg Municipality, Gdańsk Science & Techn. Park, Norgenta

Results: • Production of a Compendium, Development of a Roadmap, Implementation of regional development

activities, Building a network: more: http://www.submariner-project.eu/ http://www.submariner-network.eu/

© BioCon Valley® GmbH · Greifswald / Rostock 1227.10.2015

Proposal „Blue Biotech Alliance“

• The Baltic Blue Biotechnology Alliance project (ALLIANCE) is the response to the “Sustainable Blue Growth Agenda for the Baltic Sea Region” adopted by the European Commission (May 2014) that provides the blueprint for harnessing the region’s strengths to boost innovation and growth in the maritime area. The potential of blue biotechnology is therein recognised as significant but still immature and to be in need of a more strategic approach for development across the Baltic Sea Region (BSR). The ALLIANCE will bring together blue biotechnology actors from across the BSR to develop innovative marine biobased products and services.

• It aims to empower the participating research institutes, SMEs and business clusters to reach the critical mass required for action and global competitiveness by systematically pooling the national capabilities.

• Project partners will closely work together with two main target groups to address their needs: 1) business as the customers and shapers of the ALLIANCE (startups, spinoffs, SMEs, industry) and 2) research institutes, innovation agencies and business parks within the ALLIANCE and beyond.

• Key Figures:– Submission: July 14th, 2015– Planned run time: Mar 2016-Dec 2018– Partner: 23 (DE, DK, EE, FI, LT, LV, PL, PO, SE, UK); incl 10 “cases” to initiate and practice

transfer of expertise from science to companies– Lead: Geomar Kiel– Budget: 3,2 Mio€

27.10.2015 © BioCon Valley® GmbH · Greifswald / Rostock 13

27.10.2015 Test BCV 14

Map of blue biotech companies in BSR*

*Source: http://www.submariner-project.eu

No Country

5 EE

1 Fi

3 Lv

2 Lt

2 Pl

5 Dk

2 Se

28 De

48 Total BSR

27.10.2015 Test BCV 15

Map of blue biotech R&D in BSR*

*Source: http://www.submariner-project.eu

Gap: Blue Biotechnology Value ChainChallenge: “Absence of an integrated value chain for market uptake of Blue Biotechnology in the BSR”

Idea ……………………………………………………………..Market

© BioCon Valley® GmbH · Greifswald / Rostock27.10.2015

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Map of blue biotech industry and R&D*BBA – to Close the Gap !

*Source: http://www.submariner-project.eu

About the Organisation

Legal EntityScanBalt is a not-for-profit membership association with a legal entity registered in Denmark

General Assembly (GA) The GA is composed of the members of ScanBalt. The GA decides on change of statutes and the membership fees and advices the ExCo on the strategic development of the association.

Executive Committee (ExCo) ExCo is composed of the Founding Members of ScanBalt, up to 6 Institutional Members elected by ExCo and up to 5 Co-opted Members of strategic interest. ExCo decides on all matters relevant to ScanBalt. The primary task is to outline the strategies for the development of ScanBalt.

Chairmanship The Chairmanship of ScanBalt is responsible for representing the organisation and oversees the management. The Chairmanship is composed of a Chairman elected by ExCo and up to 4 Vice Chairmen proposed by the Chairman and approved by ExCo.

Secretariat The Secretariat of ScanBalt is located in Copenhagen, Denmark

Liaison Offices The ScanBalt Liaison Offices are regional offices undertaking specific tasks and responsibilities in dialogue with ExCo, the Chairmanship and the Secretariat.

Greifswald

e.g. Molecular Genetics: Functional genome analysis of the uncultivable symbionts ofthe deep sea tube worm Riftia pachyptila Markert et al. Science 2007

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e.g. Isolation, Cultivation, Taxonomy : Typical ascospore of C. maritima

www.marine-biotechnologie.de

Rostock

e.g. Product development:Prevention of nosocomialinfections by Maresome®

e.g. Pharmaceutical Analysis:Ascochitale from

Kirschsteiniothelia maritima

Marine Biotech Mecklenburg -Vorpommern

highlights, e.g.• Internationale Conferences on MBT in Greifswald:

− 1996: „Stand und Perspektiven der marinen Biotechnologie in Deutschland“

− 1999: „Marine Biotechnology and Biosensors“− 2002: „Natural Products from Marine Microorganisms“− 2006: „From Functional Genomics to Natural Products of Marine

Microorganisms“− 2011: „Microbial Interactions in Marine Systems“− 2018 : tbc „MBT – Bridging the gap“

• Start up companies:− Baltic Analytics GmbH: active− Ganomycin GmbH: failed− Ressourcenzentrum MBT GmbH: failed

• Projects, e.g.:− Biokatalyse2021 (BMBF)− Mimas (BMBF)− Submariner (EU)

www.marine-biotechnologie.de

Thank you for your Attention !

www.bcv.orgwww.scanbalt.org

ScanBalt fmba BioCon Valley® GmbHAllegade 14, Walther-Rathenau-Str. 49a Friedrich-Barnewitz-Str. 8DK-2000 Frederiksberg D-17489 Greifswald D-18119 RostockTel: + 45 27141078 Tel.:+49 3834 515-30 Tel.:+49 381 5196-4953pf@scanbalt.org Fax:+49 3834 515-102 Fax:+49 381 5196-495