mars health innovation platform - cadth.ca · s visit us at marsdd.com mars health innovation...
TRANSCRIPT
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PIN
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T bull
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OW
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UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Visit us at marsddcom
MaRS Health Innovation Platform
A P R I L 1 1 2 0 1 6
Zayna Khayat PhD Sr Advisor Health System Innovation Lead Director MaRS EXCITE MaRS Discovery District zkhayatmarsddcom ZaynaKhayat
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Hurdles to full value capture from med tech
6 Adoption
Patients accessing
technology
Time
1 Evidence
2 Licensing
3 HTA Coverage decision
4 Funding fee codes hellip
5 Procurement
(+ Obsolescence of old)
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Impact Potential
Gravity of unmet need
Degree of
ldquoNewnessrdquo
Vs Std of Care
MaRS Health Innovation Platform
helping improve med tech value proof
Pay-for-performance vehicles in healthcare
Liberating health data flow to
enhance med tech value
Pull model for health technology adoption and diffusion
Building a competitive global med tech industry
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
A new paradigm for Evidence-to-Policy-to-Practice
Reframe Innovationindustry - part of the health system not apart from it
Shortfalls of how breakthrough tech gets to patients today
ndash Regulation and reimbursement processes discrete sequential
ndash Evidence used to ldquopolicerdquo adoption following regulation ndash too late expensive inefficient
ndash Even if positive funding decision lowslowno uptake
ndash Canadian technology originators bypassing home market
EXCITE Harmonized pre-market process addresses regulatory coverage amp adoption concerns hellip efficiently
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The Big Idea Start HTA Earlier hellip
In Collaboration with Payers amp Regulators
Netherlands
NHS
Ontario + UK + US
bull Qualitative research ndash patients clinicians hellip bull Quantiative ndash theoretical HTA
bull Review of clinical trial design data
~10 US payers
bull Review of clinical trial design bull Review of market access plan
bull Design + execute pivotal study that reflects hellip bull hellip Needs of payers amp regulators lsquocuz they are involved at front end
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The EXCITE Model A new Paradigm
Regulator TIME
U
Pre-Launch Post-Launch
RampD
Obsolescence
Yes -Diffusion
Payer
No
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Health System
Academic HTA
Regulators
Industry
+ 24 research hospitals
+ gt30 community health orgs + 15 others
EXCITE A Collaboration on Steroids
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Hurdles to full value capture from med tech
6 Adoption
Patients accessing
technology
Time
1 Evidence
2 Licensing
3 HTA Coverage decision
4 Funding fee codes hellip
5 Procurement
(+ Obsolescence of old)
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Impact Potential
Gravity of unmet need
Degree of
ldquoNewnessrdquo
Vs Std of Care
MaRS Health Innovation Platform
helping improve med tech value proof
Pay-for-performance vehicles in healthcare
Liberating health data flow to
enhance med tech value
Pull model for health technology adoption and diffusion
Building a competitive global med tech industry
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
A new paradigm for Evidence-to-Policy-to-Practice
Reframe Innovationindustry - part of the health system not apart from it
Shortfalls of how breakthrough tech gets to patients today
ndash Regulation and reimbursement processes discrete sequential
ndash Evidence used to ldquopolicerdquo adoption following regulation ndash too late expensive inefficient
ndash Even if positive funding decision lowslowno uptake
ndash Canadian technology originators bypassing home market
EXCITE Harmonized pre-market process addresses regulatory coverage amp adoption concerns hellip efficiently
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The Big Idea Start HTA Earlier hellip
In Collaboration with Payers amp Regulators
Netherlands
NHS
Ontario + UK + US
bull Qualitative research ndash patients clinicians hellip bull Quantiative ndash theoretical HTA
bull Review of clinical trial design data
~10 US payers
bull Review of clinical trial design bull Review of market access plan
bull Design + execute pivotal study that reflects hellip bull hellip Needs of payers amp regulators lsquocuz they are involved at front end
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The EXCITE Model A new Paradigm
Regulator TIME
U
Pre-Launch Post-Launch
RampD
Obsolescence
Yes -Diffusion
Payer
No
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Health System
Academic HTA
Regulators
Industry
+ 24 research hospitals
+ gt30 community health orgs + 15 others
EXCITE A Collaboration on Steroids
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Impact Potential
Gravity of unmet need
Degree of
ldquoNewnessrdquo
Vs Std of Care
MaRS Health Innovation Platform
helping improve med tech value proof
Pay-for-performance vehicles in healthcare
Liberating health data flow to
enhance med tech value
Pull model for health technology adoption and diffusion
Building a competitive global med tech industry
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
A new paradigm for Evidence-to-Policy-to-Practice
Reframe Innovationindustry - part of the health system not apart from it
Shortfalls of how breakthrough tech gets to patients today
ndash Regulation and reimbursement processes discrete sequential
ndash Evidence used to ldquopolicerdquo adoption following regulation ndash too late expensive inefficient
ndash Even if positive funding decision lowslowno uptake
ndash Canadian technology originators bypassing home market
EXCITE Harmonized pre-market process addresses regulatory coverage amp adoption concerns hellip efficiently
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The Big Idea Start HTA Earlier hellip
In Collaboration with Payers amp Regulators
Netherlands
NHS
Ontario + UK + US
bull Qualitative research ndash patients clinicians hellip bull Quantiative ndash theoretical HTA
bull Review of clinical trial design data
~10 US payers
bull Review of clinical trial design bull Review of market access plan
bull Design + execute pivotal study that reflects hellip bull hellip Needs of payers amp regulators lsquocuz they are involved at front end
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The EXCITE Model A new Paradigm
Regulator TIME
U
Pre-Launch Post-Launch
RampD
Obsolescence
Yes -Diffusion
Payer
No
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Health System
Academic HTA
Regulators
Industry
+ 24 research hospitals
+ gt30 community health orgs + 15 others
EXCITE A Collaboration on Steroids
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
A new paradigm for Evidence-to-Policy-to-Practice
Reframe Innovationindustry - part of the health system not apart from it
Shortfalls of how breakthrough tech gets to patients today
ndash Regulation and reimbursement processes discrete sequential
ndash Evidence used to ldquopolicerdquo adoption following regulation ndash too late expensive inefficient
ndash Even if positive funding decision lowslowno uptake
ndash Canadian technology originators bypassing home market
EXCITE Harmonized pre-market process addresses regulatory coverage amp adoption concerns hellip efficiently
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The Big Idea Start HTA Earlier hellip
In Collaboration with Payers amp Regulators
Netherlands
NHS
Ontario + UK + US
bull Qualitative research ndash patients clinicians hellip bull Quantiative ndash theoretical HTA
bull Review of clinical trial design data
~10 US payers
bull Review of clinical trial design bull Review of market access plan
bull Design + execute pivotal study that reflects hellip bull hellip Needs of payers amp regulators lsquocuz they are involved at front end
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The EXCITE Model A new Paradigm
Regulator TIME
U
Pre-Launch Post-Launch
RampD
Obsolescence
Yes -Diffusion
Payer
No
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Health System
Academic HTA
Regulators
Industry
+ 24 research hospitals
+ gt30 community health orgs + 15 others
EXCITE A Collaboration on Steroids
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The Big Idea Start HTA Earlier hellip
In Collaboration with Payers amp Regulators
Netherlands
NHS
Ontario + UK + US
bull Qualitative research ndash patients clinicians hellip bull Quantiative ndash theoretical HTA
bull Review of clinical trial design data
~10 US payers
bull Review of clinical trial design bull Review of market access plan
bull Design + execute pivotal study that reflects hellip bull hellip Needs of payers amp regulators lsquocuz they are involved at front end
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The EXCITE Model A new Paradigm
Regulator TIME
U
Pre-Launch Post-Launch
RampD
Obsolescence
Yes -Diffusion
Payer
No
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Health System
Academic HTA
Regulators
Industry
+ 24 research hospitals
+ gt30 community health orgs + 15 others
EXCITE A Collaboration on Steroids
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
The EXCITE Model A new Paradigm
Regulator TIME
U
Pre-Launch Post-Launch
RampD
Obsolescence
Yes -Diffusion
Payer
No
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Health System
Academic HTA
Regulators
Industry
+ 24 research hospitals
+ gt30 community health orgs + 15 others
EXCITE A Collaboration on Steroids
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Health System
Academic HTA
Regulators
Industry
+ 24 research hospitals
+ gt30 community health orgs + 15 others
EXCITE A Collaboration on Steroids
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
Examples of Projects in the Program
P U B L I C LY D I S C L O S A B L E P R O J E C T S A R E hellip
bull Bresotec ndash Home sleep apnea diagnostic test
bull Medtronic ndash Renal denervation for hypertension (discontinued)
bull Rna Diagnostics ndash Rna disruption for early prediction of response to chemo in breast cancer
bull MyndTec ndash Electrical stimulation to restore voluntary upper limb movements post stroke
bull Aegis ndash Left atrial appendage closure device for stroke reduction in patients with atrial fibrillation
bull AssureRx Health- primary care pharmacogenomics test for schizophrenia and major depressive disorder
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 1 Conditions of Adoption
To read the full report visit wwwohicca
February 2016
Projected Adoption Rates
Infrastructure Readiness
Reimbursement Considerations
Economic Projections
Knowledge Translation
Procurement
EXCITE + Ontario Office of Chief Health Innovation Strategist work collaboratively to prepare the system infrastructure for adoption bull 1st completed EXCITE evidence package June lsquo16 Home apnea Dx
Factors Affecting Successful Adoption
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
Whatrsquos next 2 EXCITE International
February 2016
bull Incorporated separate entity (February 2016)
bull Single platform for companies to conduct multi-jurisdictional harmonized clinical trials amp early HTA
bull Starting with UK US Canada NZ
bull Next summit June 23 MaRS
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters
EXCITE INTERNATIONAL
SECRETARIAT
bull Coordinates multinational evaluations for MNEs amp SMEs
bull Facilitates methodologist centre quality frameworks
bull Advisesassists members in setting up local EXCITE ndash like operations
February 2016
International Board
International Scientific Collab
International Leadership Centres
EXCITE International Affiliates
V E R Y P R E L I M I N A R Y
C A N A D A ( M A R S )
Develop accepted frameworks to assist EXCITE International affiliates in their work
U S U K E U R O P E hellip N Z
EXCITE International Working Model
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E
DE
VE
LO
PIN
G T
AL
EN
T bull
GR
OW
ING
VE
NT
UR
ES
bull O
PE
NIN
G M
AR
KE
TS
Our Future Matters February 2016
ZAYNA KHAYAT Director
zkhayatmarsddcom
KAROL KAMECKA Coordinator
kkameckamarsddcom
LIANA DI MARCO Project Manager ldimarcomarsddcom
LES LEVIN Chief Scientific Officer llevinmarsddcom
LILY LO Senior Associate llomarsddcom
F O R M O R E I N F O R M A T I O N V I S I T W W W E X C I T E M A R S D D C O M
T W I T T E R M A R S E X C I T E