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INORGANIC SYNTHESIS
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• 1- Jack T. Ballinger, Gershon J. Shugar; Chemical Technicians' Ready Reference Handbook, 5th
Edition, McGraw-Hill Education: New York, 2011.
• 2- Ruren Xu, Yan Xu; Modern Inorganic Synthetic Chemistry, 2ed Edition, Elsevier: 2017.
• 3- John N. Lalena, David A. Cleary, Everett E. Carpenter, Nancy F. Dean; Inorganic Materials
Synthesis and Fabrication, Elsevier: 2017.
• 4- Sneha Mohan Bhagyaraj, Oluwatobi Samuel Oluwafemi, Nandakumar Kalarikkal, Sabu
Thomas; Synthesis of Inorganic Nanomaterials, Elsevier: 2018.
• 5- C.N.R. Rao, Kanishka Biswas; Essentials of Inorganic Materials Synthesis, Wiley: 2014.
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http://r.takjoo.profcms.um.ac.ir/
English
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• MSDS (Material Safety Data Sheet)
product safety data sheet (PSDS)
• Laboratory Health and Safety
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What is a Material Safety Data Sheet (MSDS)?
A material safety data sheet is a technical document which provides detailed
and comprehensive information on a controlled product related to:
• health effects of exposure to the product
• hazard evaluation related to the product’s handling, storage or use
• measure to protect workers at risk of exposure
• emergency procedures
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Responsibilities Related to the MSDS
• Suppliers
• Employer
• Worker
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Suppliers
1. Develop or obtain a MSDS for each controlled product imported or sold for
use in a workplace
2. Ensure the MSDS for the controlled product:
• Discloses information that is current at the time of sale or importation of the
product
• Was prepared and dated not more than three years before the date of sale or
importation
• Is available in both official languages Ferdow
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Suppliers
3. Ensure the purchaser of the controlled product has a copy of the current
MSDS at the time of or prior to the purchaser receiving the controlled product
4. Make available any information that is considered confidential (trade secret)
information and therefore exempt from disclosure to any physician or nurse
who requests that information for the purpose or making a medical diagnosis or
providing medical treatment
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Employer
1. Ensures that an up-to-date supplier MSDS is obtained from the supplier the first
time a controlled product is received in the workplace
2. Evaluates the data sheet received to determine its date of production. The data sheet
must be dated within 3 years of current date
3. Maintains up-to-date MSDSs:
- As soon as practical but no later than 90 days after new hazard information becomes
available to the employer
- At least every three years
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Employer
4. Ensures a copy of all data sheets which are required for the workplace are made
readily available at the worksite to:
Workers who may be exposed to the controlled product
The occupational health committee (OHC)
Note: The MSDSs may be made available on a computer if the employer takes all
reasonable steps to keep the terminal in working order, makes the data sheets readily
available to the employee and provides training in accessing the computer stored data
to the employee. Ferdow
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Employer
5. Ensure that the employee who works with a controlled product or in proximity to a
controlled product is instructed in:
The content required on the MSDS
The purpose and significance of information contained in it
Instruction must ensure that employees know procedures for the safe use, storage,
handling and disposal of controlled products including procedures in the event of an
emergency involving a controlled product.
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Employer
6. Provide confidential (trade secret) information to a doctor or nurse who request this
information for purposes of making a medical diagnosis or rendering medical
treatment in an emergency
7. The employer can produce data sheets in order to provide additional information or
alter the format used as long as there is no less information provided than the original
supplier MSDS contained
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Worker
Worker Following training by the employer:
1. Follows the safe work or preventative measures as instructed by the employer
2. Knows where the sheets are located and how to find pertinent information on
safe use and first aid measures
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Material Safety Data Sheet Content
• A supplier material safety data sheet must provide at least nine categories or
sections of content and approximately sixty items of information distributed
among those categories. An MSDS must be reviewed at least every three
years. The categories must have the following similar headings:
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The LD50 is defined as the lethal dose at which 50% of the
population if killed in a given period of time; an LC50 is the
lethal concentration required to kill 50% of the population.
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• SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
• 1.1. PRODUCT IDENTIFIER
• 1.2. RELEVANT IDENTIFIED USES OF THE SUBSTANCE OR MIXTURE AND USES ADVISED AGAINST
• 1.3. DETAILS OF THE SUPPLIER OF THE SAFETY DATA SHEET
• 1.4. EMERGENCY TELEPHONE NUMBER
• SECTION 2: HAZARDS IDENTIFICATION
• 2.1. CLASSIFICATION OF THE SUBSTANCE OR MIXTURE
• 2.2. LABEL ELEMENTS
• 2.3. OTHER HAZARDS
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• SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
• 3.1. SUBSTANCES
• 3.2. MIXTURES
• SECTION 4: FIRST AID MEASURES
• 4.1. DESCRIPTION OF FIRST AID MEASURES
• 4.2. MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED
• 4.3. INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED
• SECTION 5: FIREFIGHTING MEASURES
• 5.1. EXTINGUISHING MEDIA
• 5.2. SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE
• 5.3. ADVICE FOR FIREFIGHTERSFerdow
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• SECTION 6: ACCIDENTAL RELEASE MEASURE
• 6.1. PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES
• 6.2. ENVIRONMENTAL PRECAUTIONS
• 6.3. METHODS AND MATERIAL FOR CONTAINMENT AND CLEANING UP
• 6.4. REFERENCE TO OTHER SECTIONS
• SECTION 7: HANDLING AND STORAGE
• 7.1. PRECAUTIONS FOR SAFE HANDLING
• 7.2. CONDITIONS FOR SAFE STORAGE, INCLUDING ANY INCOMPATIBILITIES
• 7.3. SPECIFIC END USE(S)
• SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
• 8.1. CONTROL PARAMETERS
• 8.2. EXPOSURE CONTROLS
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• SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
• 9.1. INFORMATION ON BASIC PHYSICAL AND CHEMICAL PROPERTIES
• 9.2. OTHER INFORMATION
• SECTION 10: STABILITY AND REACTIVITY
• 10.1. REACTIVITY
• 10.2. CHEMICAL STABILITY
• 10.3. POSSIBILITY OF HAZARDOUS REACTIONS
• 10.4. CONDITIONS TO AVOID
• 10.5. INCOMPATIBLE MATERIALS
• 10.6. HAZARDOUS DECOMPOSITION PRODUCTS
• SECTION 11: TOXICOLOGICAL INFORMATION
• 11.1. INFORMATION ON TOXICOLOGICAL EFFECTS
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• SECTION 12: ECOLOGICAL INFORMATION
• 12.1. TOXICITY
• 12.2. PERSISTENCE AND DEGRADABILITY
• 12.3. BIOACCUMULATIVE POTENTIAL
• 12.4. MOBILITY IN SOIL
• 12.5. RESULTS OF PBT AND VPVB ASSESSMENT
• 12.6. OTHER ADVERSE EFFECTS
• SECTION 13: DISPOSAL CONSIDERATIONS
• 13.1. WASTE TREATMENT METHODS
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• SECTION 14: TRANSPORT INFORMATION
• 14.1. UN NUMBER
• 14.2. UN PROPER SHIPPING NAME
• 14.3. TRANSPORT HAZARD CLASS(ES)
• 14.4. PACKING GROUP
• 14.5. ENVIRONMENTAL HAZARDS
• 14.6. SPECIAL PRECAUTIONS FOR USER
• 14.7. TRANSPORT IN BULK ACCORDING TO ANNEX II OF MARPOL73/78 AND THE IBC CODE
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• SECTION 15: REGULATORY INFORMATION
• 15.1. SAFETY, HEALTH AND ENVIRONMENTAL REGULATIONS/LEGISLATION SPECIFIC FOR THE
SUBSTANCE OR MIXTURE
• 15.2. CHEMICAL SAFETY ASSESSMENT
• SECTION 16: OTHER INFORMATION
• 16.2. DATE OF THE LATEST REVISION OF THE SDS
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Laboratory Health and Safety
• Jack T. Ballinger, Gershon J. Shugar; Chemical
Technicians' Ready Reference Handbook, 5th Edition,
McGraw-Hill Education: New York, 2011.
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• Health Safety at Work etc Act 1974
• Penalty – up to 2 year in prison &/or an unlimited fine
• The Management of Health and Safety at Work Regs 1999
• Control of Substances Hazardous to Health Regs 2004
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Workplace Hazardous Materials Information System
• 2004
• American standard: ANSI Z400.1-2004
• 16 section
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General Safety Equipment
shower
PPE
waste disposal
fire safetyeye washer
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Facilities and Safety - Module 238
Standard Safety Practices
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SAFETY SIGNS
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Research Employee Injuries (1993–1997)
Howard Hughes Medical Institute, Office of Laboratory SafetyFerdow
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Facilities and Safety - Module 241
Laboratory Support Injuries (1993–1997)
Howard Hughes Medical Institute, Office of Laboratory SafetyFerdow
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LABORATORY HAZARDS
•PHYSICAL
•CHEMICAL
•BIOLOGICAL
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Bites, scratches
animal or
ectoparasites
Spills, sprays
Aspiration through pipettes
broken glass, sharps
needles, syringes
Accidents,injuries
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PHYSICAL HAZARDS
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Facilities and Safety - Module 245
do not recap needles
always use puncture-resistant, leakproof,sharps containers
always use specific waste disposal containers
never directly handle broken glass
Needles, Broken Glass, and Sharps
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Facilities and Safety - Module 246
Do you see anything wrong?
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Facilities and Safety - Module 247
Do NOT reuse disposable injection equipment
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CHEMICAL HAZARDS
BIOSAFETY LEVEL 1 AND 2
LABORATORIES
SEPARATE CABINETS FOR STORAGE:
SPILL CONTAINMENT CABINET
HAZARDOUS WASTE STORAGE
FLAMMABLE LIQUIDS STORAGE
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Facilities and Safety - Module 249
MATERIAL SAFETY DATA SHEET
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50
THE RISKS FOR LABORATORY WORKERS-MOST FREQUENTLY REPORTED INFECTIONS IN US, 1979-1999
Disease or Agent No. of CasesMycobacterium tuberculosis 223
Q fever 176
Hantavirus 169
Hepatitis B virus 84
Brucella sp. 81
Salmonella sp. 66
Shigella sp. 56
Hepatitis non-A, non-B 28
Cryptosporidium sp. 27
Total 1074Ferdow
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BIOLOGICAL HAZARDS
AEROSOLS AND DROPLETS ARE THE MAIN
SOURCES OF CONTAMINATION
MODIFIED SLIDE 41->42Ferd
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SINGLE-SOURCE, MULTIPLE LABORATORY INFECTIONS
Disease Probable Source Max Distance from Source
Number Infected
Brucellosis Centrifugation Basement to 3rd
floor94
Coccidioidomycosis Culture transfer
solid media
2 building floors 13
Coxsackie
Virus infection
Spilled tube of infected mouse tissue on floor
5 feet estimated 2
Murine Typhus Intranasal inoculation
of mice
6 feet estimated 6
Tularemia 20 Petri plates dropped
70 feet 5
Venezuelan
encephalitis
9 lyophilized
ampoules dropped
4th floor stairs to 3rd or 5th floor
24
Reitman and Wedum, 1956
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Facilities and Safety - Module 253
CONTAMINATION ROUTES
Ocular invasion
Inhalation
Ingestion
Skin penetration
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Facilities and Safety - Module 254
PERSONAL PROTECTIVE EQUIPMENT
BSL 1 AND 2
LABORATORY COAT
GLOVES
GOGGLES OR FACE SHIELD
MASKS
HEARING PROTECTION
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Facilities and Safety - Module 255
Minor spill
Major spill
Chemical Spills anything beyond a minor spill and requiring help from outside of the laboratory group constitutes a major spill
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Facilities and Safety - Module 256
Biological Spills
Spill Exercises
Spill Exercises
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Facilities and Safety - Module 257
Learn how to operate a portable fire extinguisher
Laboratory Fire Safety
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Facilities and Safety - Module 258
QUESTIONS?
COMMENTS?
Organization Personnel Equipment
Purchasing
&
Inventory
Process
Control
Information
Management
Documents
&
Records
Occurrence
ManagementAssessment
Process
Improvement
Customer
Service
Facilities
&
Safety
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