master thesis position in cancer biology - uzh7dfdda96-70cd-43f2-91b3-253ffbf5… · prof. massimo...

September 2018 Master Thesis Position in Cancer Biology Prof. Massimo Lopes Group Institute of Molecular Cancer Research DNA replication and replication stress in hematopoietic stem cells Background: Hematopoiesis is essential for life, and its deregulation leads to impacting diseases such as leukemia or Fanconi anemia. Organisms need to sporadically stress their hematopoietic system, for example during an infection or after heavy bleeding, increasing the proliferation rate of the hematopoietic stem cell compartment. This leads to DNA damage, but the underlying mechanisms are still unclear. Project outline: The aim of this project is to study DNA replication and DNA damage directly in mouse hematopoietic stem cells. By using already optimized specialized techniques, the student will test the effect of selected treatments, as well as study transgenic mouse models to gain insight in carcinogenesis and genetic diseases. Techniques: More specifically, we use bone marrow extraction, FACS, immunofluorescence, COMET assays, automated microscopy, DNA fiber technique and DNA combing, and electron microscopy. Team: We look for someone motivated to join a group of enthusiastic people, working on diverse aspects of DNA replication stress. The student would be supervised by postdoctoral researcher Kurt Jacobs, and could start as soon as possible. Interested candidates should send their CV and a short motivational letter to [email protected] Institute of Molecular Cancer Research

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Page 1: Master Thesis Position in Cancer Biology - UZH7dfdda96-70cd-43f2-91b3-253ffbf5… · Prof. Massimo Lopes Group Institute of Molecular Cancer Research DNA replication and replication

September2018

MasterThesisPositioninCancerBiologyProf.MassimoLopesGroupInstituteofMolecularCancerResearch

DNAreplicationandreplicationstressinhematopoieticstemcellsBackground:Hematopoiesisisessentialforlife,anditsderegulationleadstoimpactingdiseases such as leukemia or Fanconi anemia. Organisms need to sporadically stresstheir hematopoietic system, for example during an infection or after heavy bleeding,increasingtheproliferationrateofthehematopoieticstemcellcompartment.ThisleadstoDNAdamage,buttheunderlyingmechanismsarestillunclear.Projectoutline:Theaimof thisproject is tostudyDNAreplicationandDNAdamagedirectly in mouse hematopoietic stem cells. By using already optimized specializedtechniques, the student will test the effect of selected treatments, as well as studytransgenicmousemodelstogaininsightincarcinogenesisandgeneticdiseases.Techniques: More specifically, we use bone marrow extraction, FACS,immunofluorescence,COMETassays,automatedmicroscopy,DNAfiber techniqueandDNAcombing,andelectronmicroscopy.Team:Welookforsomeonemotivatedtojoinagroupofenthusiasticpeople,workingon diverse aspects of DNA replication stress. The student would be supervised bypostdoctoralresearcherKurtJacobs,andcouldstartassoonaspossible.Interested candidates should send their CV and a short motivational letter [email protected]

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