mastersizer
DESCRIPTION
mastersizer 3000 specificationsTRANSCRIPT
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Welcome to the next generation
Mastersizer 3000Smarter particle sizing
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Not just a new instrument a new Mastersizer First Mastersizer launched in 1988 Now more than 10,000 users worldwide Laser diffraction has become the worlds most widely used particle sizing technique Malvern Instruments is the global leader for particle sizing technology and applications understanding
Mastersizer Particle sizing has evolved
1988 1998 2011
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The new Mastersizer 3000 at a glance
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The new Mastersizer 3000 at a glance
State-of-the-art compact instrument design Class-leading performance 10nm to 3.5mm Rapid measurements Robust results Rapid and effective wet dispersion Efficient in-line sonication Cutting-edge dry dispersion Suitable for fragile and cohesive samples Software that lightens your workload Effortless work not guess work!
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Laser Diffraction: reasons for success
Wide dynamic range From the nanometre to the millimetre size range Rapid measurements Results possible in less than a minute Repeatability Large number of particles sampled High sample throughput Hundreds of measurements can be made in a day Calibration not necessary Easily verified using standard reference materials Well established technique, covered by ISO13320 (2009) Describes general principles and expected performance
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Transmit a laser through a dispersion of particles Angle of diffraction depends upon particle size Large particles scatter at smaller angles Small particles scatter light at wider angles
Images: Dr Kevin Powers, PERC, University of Florida
5 microns 800 nanometres
Laser diffraction how does it work?
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Measurement cell Focal plane
detectors
Side scatter
detectors
Back scatter
detectors
633nm red
laser
Precision
folded optics
Mastersizer 3000 optics: red light measurements
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Mastersizer 3000 optics: blue light measurements
470nm blue
light source
Side scatter
detectors
Measurement cell
Back scatter
detectors
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Mastersizer 3000 : Delivers performance
Widest measurement range 10nm - 3.5mm measurement range Excellent sub-micron resolution Powerful 20mW blue solid state light source Fast measurement times Rapid system initialisation and measurement cycle Sampling, measurement, cleaning in
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Size / Pm0.01 0.1 1 10 100 1000 10000
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Icing Sugar
Castor Sugar
Granulated Sugar
Mastersizer 3000: Wide dynamic range
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Particle Size / Pm0.01 0.1 1 10
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30nm
46nm
100nm
220nm
500nm
700nm
1300nm
2000nm
3000nm
5000nm
9000nm
Mastersizer 3000: Sub-micron resolution
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Mastersizer 3000: measurement robustness
Dv50 RSD (fine): 0.34% Dv50 RSD (coarse): 0.7%Size / Pm0.1 1 10 100 1000
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Feed
Fines
Measurement Number
0 10 20 30 40 50 60S
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Dv10 Dv50 Dv90
Alternating between fine and coarse samples
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Mastersizer 3000: Lightens your workload
Fast results and method development Real-time optimization of each measurement Flexible, user-independent operation Easily switched dispersion units with auto locking cells Automatic initialisation for robust measurements Software that delivers your data, your way Edit-in-place report designer Free up bench space Compact footprint and dispersion accessories Top class support Built-in intelligence - Malvern experts on-demand
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Software: Measurement Manager
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Measurement Manager: Observe
View measurement parameters and particle size distribution Instant feedback of results
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Measurement Manager: Interact
Full control of all dispersion parameters at your fingertips
Real-time control over your method development
Change sample documentation on the fly
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Rolling trend plotting and statistics Rapid method optimization in line with ISO 13320 guidance
Measurement Manager: Optimize
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Software: viewing your results
Rapid result review
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Software: simple and flexible data reporting
Simple measurement reporting
Confidential. Malvern Instruments 2011
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Software: reviewing your results and methods
Accessible data
Confidential. Malvern Instruments 2011
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Software: expert advice for better results
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Wet or dry: a solution for every application
Wet sample dispersion Hydro range Powerful and rapid sample dispersion A range of sample volumes to suit your application Dry sample dispersion Aero range Completely new, state of the art technology Flexibility to disperse cohesive and fragile powders
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Mastersizer: Hydro wet dispersion units
All dispersion accessories: Achieve excellent dispersion with powerful centrifugal pump and
stirrer Fast dispersion of cohesive samples with in-line sonication Chemically compatible internally as standard Full software control over the sample dispersion Integral tank light for viewing the dispersant and sample
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Mastersizer Hydro - Accessories
Hydro MV Medium sample volume - 120ml Fully automated cleaning Hydro LV Large sample volume - 600ml Fully automated cleaning Hydro EV Exchangeable sample volume
250ml / 600ml / 1000ml Easy sample recovery
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Hydro MV and Hydro LV: how they work
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Hydro unit measurement cell
Automatically locked into measurement position System recognises cell type Windows can be quickly removed without needing special tools Jacketed heating/cooling for rapid temperature stabilisation Chemically compatible seals
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Hydro EV: sampling performance
Copper powder - density 8.92 g/cm3 Stir speed titration stable >2500 rpm
stir speed / rpm
500 1000 1500 2000 2500 3000 3500 4000
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60
80
100
120
140
160
180
Dv10
Dv50
Dv90
stir speed / rpm
500 1000 1500 2000 2500 3000 3500 4000
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-10
-5
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obscurationDv10
Dv50
Dv90
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In-line sonication : rapid and efficient dispersion
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measurement no.
0 5 10 15 20 25 30
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Dv10
Dv50
Dv90
HYDRO MV HYDRO LVHYDRO EV
Hydro unit reproducibility
15 20 25 300 5 1010
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Benefits of dry dispersion
Fundamentally new design state-of-the art knowledge Fast measurement times Excellent sampling of polydisperse materials Flexible dispersion power - apply the appropriate dispersion energy Environmental and safety no solvent disposal
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Wide size range 0.1 Pm to 3500 Pm Precise pressure control 0.1 to 4.0 bar Modular venturi disperser Standard suitable for most powders Options for extremely cohesive or abrasive Modular sample tray design Adjustable sample hopper Full software control of sample feed and dispersion
Aero S Dry Powder Disperser
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Aero S: modular venturi for flexibility
Modular Easy Changeover Plug-and play Automatically recognized Standard Venturi Right angle design Suitable for most types of sample HE Venturi Elbow design (cf. Scirocco) High energy for very cohesive samples
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Aero S: optimum sample feed
Hopper and tray assembly Hopper vibrates with the tray Height can be adjusted A basket can be fitted into the hopper if required. Configuration of the hopper and tray is auto-detected
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Automatically locked into measurement position System recognises cell type Windows can be quickly removed for cleaning without needing any
tool Vacuum connection is on the optical bench Sheath air flow is filtered
Aero S: measurement cell
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Size / Pm10 100 1000
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4 bar
3 bar
2 bar
1 bar
0.5 bar
Aero S: wide dynamic range and sampling
Coffee - polydisperse, >3mm, sticky due to oils
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Aero S: wide dynamic range
Size / Pm10 100 1000
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Expresso
Smooth
Filter
Coffee: polydisperse samples up to 3.5mm
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Aero S: fragile samples
Sucralose is a typical fragile material Challenge to disperse samples without breaking primary particles Need enough energy but not too much Aero S standard venturi is ideal for fragile materials
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Presure / bar
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0
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Dv10
Dv50
Dv90
Dv10
Dv50
Dv90
Stable dispersion below 1.0 barSucralose: Aero S Standard Venturi
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Presure / bar
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0
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Dv10
Dv50
Dv90
Dv10
Dv50
Dv90
No stable region down to 0.1 barSucralose: High Energy Venturi
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Measurement Number
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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14
Dv10
Dv50
Dv90
Size / Pm0.01 0.1 1 10 100 1000F
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Cohesive sample: Aero S standard venturi
Size / Pm 10 100 1000
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Size / Pm0.01 0.1 1 10 100 1000
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2.13%
6.33%
9.41%
14.08%
17.42%
21.92%
37.64%
Aero S: robust performance
Obscuration (%)
0 5 10 15 20 25 30 35 40
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Dv10
Dv50
Dv90
Cement stable over a wide obscuration range Dv10: 2.4%, Dv50: 0.5%, Dv90: 1.0%
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Mastersizer 3000: R&D Environment
High performance Wide particle size range Excellent sub-micron resolution Fully flexible system Range of dispersion accessories to suit your sample Easy changeover of dispersion accessories Build custom reports in a few mouse clicks Your data, your way Easy to use Does not require expert operator In-built intelligence and expertise
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Mastersizer 3000: QC Environment
Boost productivity and throughput Fast measurement times Fully automated measurement and cleaning Easy to use Does not require expert operator In-built intelligence and expertise Robust results Lockdown your methods with SOPs Validatable performance
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Mastersizer 3000 - Pharmaceuticals
Highest performance Flexibility combined with ease-of use One platform right across the development cycle Easy transfer of methods from R&D to QC Aero S offers excellent dry
dispersion performance for fragile
materials such as actives Full IQ/OQ/PQ validation available CFR21 part 11 compliance
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Mastersizer 3000 - Summary
High performance Wide size range Fast measurements Robust results Flexible Range of wet and dry dispersion units Easy changeover, auto-locking cells Full manual control and SOP modes Easy to use From novice to expert Malvern expertise inside More Information : www.malvern.com/MS3000
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Questions or Feedback?