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What Are Mast Cells?

What is Mastocytosis?

Heterogeneous group of disorders characterized by;

abnormal clonal expansion & accumulation of mast cells in the skin &/or other organs

(e.g. bone marrow, LN, GIT, liver, spleen)

What Is The Presentation Of Mastocytosis?

Maculopapular

cutaneous mastocytosi

s

Darier sign

Solitary Mastocytoma

Darier sign

Diffuse cutaneous mastocytosis

Telangiectasia Macularis Eruptiva Perstans (TMEP)

What are The Different Types Of Mastocytosis?

What About Systemic Mastocytosis?

What Is The Cause Of Mastocytosis?

Activating mutations of c-KIT gene   

most cases it is spontaneous 

How is Mastocytosis Diagnosed?

What About Mastocytosis Biopsy?

How Is Mastocytosis Investigated?

LFTCBC

Skin biopsyBone density scan

Serum biochemistrySerum tryptase levelBone marrow biopsy

Abdominal ultrasoundBlood and marrow smears

Flow cytometry (to measure CD2 and CD25)Genetic examination (looking for KIT mutation

D816V in bone marrow mast cells)

What Should Be Avoided?

How Is Mastocytosis Treated?

R e f e r e n c e sdermnetnz.org

Google images

en.wikipedia.org

Bolognia Textbook of Dermatology 3rd ed

T H A N K Y O U