maternal disease and breastfeeding · • l3 : probably safe ... high dose metronidazole : ......

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Maternal Disease and Breastfeeding ผศ.พญ. สาวิตรี สุวิกรม โรงพยาบาลเจริญกรุงประชารักษ์ สํานักการแพทย์ กรุงเทพมหานคร

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Page 1: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Maternal Disease and Breastfeeding

ผศ.พญ. สาวิตรี สวุิกรมโรงพยาบาลเจริญกรุงประชารกัษ์

สํานกัการแพทย์ กรุงเทพมหานคร

Page 2: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Cr. : The Telegraph

Page 3: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Contraindication of Breastfeeding

• Neonatal factors : GalactosemiaMetabolic disorders

• Maternal factors : Maternal diseaseMedication during lactation

Page 4: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Medication during lactation• L1 : Safest• L2 : Safer• L3 : Probably safe• L4 : Possibly Hazardous• L5 : Hazardous

Page 5: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

L1 : Safest

Page 6: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

L2 : Safer

Page 7: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

L3 : Probably safe

Page 8: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

L4 : Possibly Hazardous

Page 9: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

L5 : Hazardous

Contraindication in breastfeeding

Page 10: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Relative Infant Dose หรือ RID

• ระดบัความปลอดภยัในการใช้ยาในช่วงให้นมลกู

ปริมาณยาที่พบในนํา้นม

RID  =   _______________________________________________________________________________   X 100 ปริมาณยาที่พบในกระแสเลือดแม่

RID ทีน้อยกวา่ร้อยละ ๑๐ เป็นยาที่ปลอดภยัที่สามารถใช้ได้ในชว่งที่ให้นมลกู

Page 11: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Maternal Disease

Cr. : Medical Career Specialists

Page 12: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Medical Illness

• Hypertension• Diabetes mellitus• Heart disease• Renal disease• Hematologic disease• Epilepsy• Hyper/hypothyroid

Safeto

breastfeed

Page 13: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Asthma

Safe to breastfeed

Cr. : Imperial College London

Page 14: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Asthma

Safe to breastfeed

Theophylline :  infant irritability and insomnia

Cr. : Imperial College London

Page 15: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Migrain• NSAIDs  :  Safe to breastfeed

Cr. : viminim

Page 16: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Migrain• NSAIDs  :  Safe to breastfeed

Ergotamine alkaloids (cafergot)  :  contraindication inhibit Prolactin decrease breastmilk

Cr. : viminim

Page 17: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Infectious disease

Cr. : www.huffingtonpost.com

Page 18: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Bacterial Infection

Safe to breastfeed

Page 19: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Bacterial Infection

Safe to breastfeed

High dose Metronidazole : delayed breastfeeding 12‐24 hr

Page 20: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Bacterial Infection

Safe to breastfeed

High dose Metronidazole : delayed breastfeeding 12‐24 hr

Chloramphenicol : bone marrow suppression

Page 21: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Bacterial Infection

Safe to breastfeed

High dose Metronidazole : delayed breastfeeding 12‐24 hr

Chloramphenicol : bone marrow suppression

Trimethoprim/sulfamethoxazole, sulfisoxazole, dapsone : Precaution in neonatal jaundice, G6PD deficiencyesp. in sick baby and preterm baby

Page 22: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Fungal Infection

Safe to breastfeed

Cr. : www.microscopy‐uk.org.uk

Page 23: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Tuberculosis (TB)

During treatment : Safe to breastfeed

1st diagnosis (sputum AFB+)  :  isolate mother for 2 wk INH prophylaxis to baby expressed breastmilk 

for baby if AFB‐ return to 

breastfeedCr. : www.radiologyassistant.nl

Page 24: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Parasitic Infection

Malaria : Safe to breastfeed

Beware use quinine and primaquine in mother with G6PD deficiency baby

Cr. : www.wired.co.uk

Page 25: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Viral Infection

Women with HIV, HTLV1, HTLV2 infection

Page 26: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Hepatitis A Infection

• Safe to breastfeed• Baby should receive immunoglobulin.

Page 27: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Hepatitis B Infection

• Safe to breastfeed• Baby should receive HBIG and Hepatitis B vaccine.

Page 28: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Hepatitis C Infection

• Safe to breastfeed

Page 29: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Varicella Zoster infection(Chicken pox)

If mother has skin lesion but baby doesn’t• separate them• give VZIG to baby• expressed breastmilk for baby except lesion around nipple

Cr. : www.md‐health.com

Page 30: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Varicella Zoster infection(Chicken pox)

If mother has skin lesion but baby doesn’t• separate them• give VZIG to baby• expressed breastmilk for baby except lesion around nipple

If both of mother and baby have lesion • continue breastfeeding

Cr. : www.md‐health.com

Page 31: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Herpes Simplex Infection

• continue breastfeeding• contact precaution

Discontinue breastfeeding only lesion around nipple

Cr. : www.maerakluke.com

Page 32: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Cancer

• Breast cancer• Other cancer

Safeto

breastfeed

Discontinue  breastfeeding while treatment bychemotherapy or radiation therapy

Page 33: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

Breast Condition

• Cracked nipple• Mastitis• Breast abscess• Breast mass excision• Breast augmentation• Breast reduction

Safeto

breastfeed

Cr. : LOOKGREATMD

Page 34: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby
Page 35: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby
Page 36: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

การคมกาํเนิดุ

ในระหว่างให้นมบตรุ

พญ. สาวิตรี สวุิกรม

Page 37: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

ถุงยางอนามัย

สามารถใช้ได้

Page 38: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

ห่วงคุมกาํเนิด

สามารถใช้ได้

Page 39: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

ยาเมด็คุมกาํเนิดชนิดที่มีฮอร์โมนเอสโตรเจนและโปรเจสเตอโรน (Combined pills) 

จะทาํให้นํา้นมลดลง

ควรหลีกเลี่ยง

Page 40: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

ยาเมด็คุมกาํเนิดชนิดที่มีฮอร์โมนโปรเจสเตอโรนอย่างเดียว

(Mini‐pills)ไม่ทาํให้นํา้นมลดลง

ExlutonCerazette

สามารถใช้ได้

Page 41: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

ยาฉีดคุมกาํเนิดชนิดฮอร์โมนโปรเจสเตอโรนอย่างเดยีว

(DMPA หรือ Depo‐provera)ไม่ทาํให้นํา้นมลดลง

แต่ควรระวังว่าถ้าฉีดก่อนที่นํา้นมจะผลิตได้เพยีงพอ (ก่อนอายุ 1 ‐2 สัปดาห์) อาจจะไปยับยัง้การออกฤทธิของฮอร์โมนโปรแลคตนิ์  ซึ่งเป็นฮอร์โมนที่ทาํ

ให้มีการผลิตนํา้นม

Page 42: Maternal Disease and Breastfeeding · • L3 : Probably safe ... High dose Metronidazole : ... Precaution in neonatal jaundice, G6PD deficiency esp. in sick baby and preterm baby

ยาฝังคุมกาํเนิด

เป็นฮอร์โมนโปรเจสเตอโรน

ออกฤทธิเหมือนยาฉีดคุมกาํเนิด์

แต่อย่ได้นานถงึู  3 – 5 ปี

สามารถใช้ได้