Dita Maria Virginia

Osteoarthritis

Rheumatoid arthritis

Osteoporosis

Gout / hiperuricemia

ARTHRITIS

common condition that causes pain and

inflammation within a joint

Klasifikasi:

Rheumatoid-arthritis (RA)

Osteo-arthritis (OA)

Genetik/family history HLA class II

Wanita

Merokok

Usia

Rheumatoid factor (RF) detectable in 60% to

70%.

Anticyclic citrullinated peptide (anti-CCP)

antibodies have similar sensitivity to RF (50%

to 85%) but are more specific (90% to 95%)

and are present earlier in the disease.

Elevated erythrocyte sedimentation rate

and C-reactive protein

Normocytic normochromic anemia is

common as is thrombocytosis.

Patofisiologi:

body's immune system attacks and destroys

the affected joints, causing pain and swelling

to occur. This can lead to a reduction in

movement and the breakdown of bone and

cartilage.

Rheumatoid nodules Vasculitis

Ocular manifestation

Pulmonary complication

Cardiac involvement

Exercises: walking, swimming

Weight reduction

Surgery

DMARD

Methotrexat

Sulfasalazine

Biologic agent

Anti TNF : infliximab

Antagonis receptor IL-1 : Antakira

NSAIDs

Corticosteroid

Menurunkan faktor-

faktor proinflamasi

Pembentuk panus

Obesitas

Umur

Hormonal

Genetik

Injury,overloading of joints, muscle

weakness, or joint deformity

Primary

Secondary

Errosive

reflects a failure of the chondrocyte to maintain

proper balance between cartilage formation and

destruction.

This leads to loss of cartilage in the joint, local

inflammation, pathologic changes in underlying

bone, and further damage to cartilage triggered

by the affected bone

Cold or warm

There is no cure for osteoarthritis, but the

symptoms can be eased with several

different treatments.

Treatment options may include: non-drug treatments, such as physiotherapy and weight

loss

medications, such as painkillers

surgery in a small number of cases, such as a knee or hip

replacement

patah tulang punggung

Rasa sakit dari sisi belakang tubuh. Setelah bertahun-tahun, patah tulang belakang yang berulangkali dapat menyebabkan nyeri punggung kronis dan tulang belakang tidak tegak lagi /melengkung, yang menyebabkan bungkuk pada punggung.

patah karena tekanan

Patah tulang yang terjadi selama aktivitas normal

patah tulang pinggul

Patah tulang panggul biasanya terjadi sebagai akibat jatuh atau kecelakaan yang tidak parah. Patah tulang pinggul juga akan sulit untuk disembuhkan setelah bedah karena kualitas tulang yang buruk.

Inhibisi resorbsi

Agonis Estrogen/ Selective Estrogen Receptor Modulators

(SERMs) raloxifene

Bisfosfonat - alendronate

Estrogen

RANK-L inhibitor denoxumab

Meningkatkan formasi tulang - Teriparatide

Mineralisasi:

Kalsitonin

Kalsium

Vitamin D

Tujuan utama manajemen osteoporosis adalah pencegahan, dengan mengoptimasi

perkembangan skeletal dan massa tulang puncak akrual saat masa kanak-kanak,

remaja dan awal dewasa akan menurunkan insiden osteoporosis di masa mendatang.

Akut gout monoarticular

Tophaceus gout ada tophy

Intercritical gout asimptomatik

Nefrolitiasis

Nefropati

Tujuan terapi untuk menghilangkan rasa nyeri serangan akut, mencegah

serangan berulang dari arthritis gout, mencegah terjadinya komplikasi,

dan mengurangi kadar serum uric acid

NSAIDs

Colchicine

Corticosteroid

Uric Acid Lowering Therapy

Xantin oxidase Inhibitor = Allopurinol

Uricosuric agents = Probenesid

phar.uokufa.edu.iq

www.cram.com

DiPiro, J.T., et al., 2009, Pharmacotherapy Handbook, Seventh edition, McGraw-Hill,

New York, pp.1516-1581.

Khanna, D., et al., 2012, 2012 American College of Rheumatology Guidelines for

Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic

Therapeutic Approaches to Hyperuricemia, Arthritis Care & Research, Vol. 64, No.

10, pp 14311446 DOI 10.1002/acr.21772

Mazzioti, G., Canalis, E., Giustina, A., 2010, Drug induced osteoporosis: mechanism and

clinical implication, The American Journal of Medicine, pp. 877-884.

McAlindon, T.E., 2014, OARSI guidelines for the non-surgical management of knee

osteoarthritis, Osteoarthritis and Cartilage, 22,pp363-388,

http://oarsi.org/sites/default/files/docs/2014/non_surgical_treatment_of_knee_oa

_march_2014.pdf

Singh, J.A., et al., 2015, 2015 American College of Rheumatology Guideline for the

Treatment of Rheumatoid Arthritis, Arthritis Care & Research, DOI

10.1002/acr.22783

Beberapa slide merupakan hasil translasi yang diambil dari makalah/tugas

Farmakoterapi 2 angkatan 2012