mcat 2015 prep
TRANSCRIPT
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MCAT 2015 PREP
Foundation Concept 1
Content Category 1A: Structure and function of proteins and their constituent
amino acids
Amino Acids (BC, OC)
Description
o Absolute configuration at the position
o
o Amino acids as dipolar ions
o Classifications
Acidic or basic
Hydrophobic or hydrophilic
Reactions
o Sulfur linkage for cysteine and cystine
o Peptide linkage: polypeptides and proteins
o Hydrolysis
Protein Structure (BIO, BC, OC)
Structure
o 1 structure of proteins
o ! structure of proteins
o " structure of proteins# role of proline$ cystine$ hydrophobic bonding
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o % structure of proteins &'()$ 'C*
Conformational stability
o Denaturing and folding
o Hydrophobic interactions
o Sol+ation layer &entropy* &'C*
Separation techni,ues
o (soelectric point
o -lectrophoresis
Non!n"ymatic Protein #unction (BIO, BC)
'inding &'C*
o Proteins bight specifically and tightly
o .ectins are a class of glycoproteins &molecules that contain protein and a sugar*$
found in /hole grains$ peanuts$ kidney beans$ and soybeans0 hey are stickymolecules that bind to the linings of human tissue$ especially intestinal cells# this
stickiness desables cells in the 2( tract$ keeping them from repairing and
rebuilding3 this can lead to erosion of your intestinal barrier &also kno/n asleaky gut*0
(mmune system
4otors
!n"yme Structure and #unction (BIO, BC)
5unction of en6ymes in cataly6ing biological reactions
-n6yme classification by reaction type
Reduction of acti+ation energy
Substrates and en6yme specificity
Acti+e Site 4odel
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(nduced7fit 4odel
4echanism of catalysis
o Cofactors
o Coen6ymes
o 8ater7soluble +itamins
-ffects of local conditions on en6yme acti+ity
Contro$ of !n"yme Acti%ity (BIO, BC)
9inetics
o 2eneral &catalysis*
o 4ichaelis4enten
o Cooperati+ity
5eedback regulation
(nhibition types
o Competiti+e
o ;on7competiti+e
o 4iymogen
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