measuring alcohol and stress interactions with structural and perfusion mri
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Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI. Chris Wyatt External Collaboration. Introduction. - PowerPoint PPT PresentationTRANSCRIPT
NA-MICNational Alliance for Medical Image Computing http://na-mic.org
Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI
Chris Wyatt
External Collaboration
National Alliance for Medical Image Computing http://na-mic.org
Size comparison of human,
rhesus, and cynomolgus brain.
Introduction
• Our goal is to use MRI to examine the effects of chronic alcohol self-administration on brain structure and function in a group of monkeys that have been mother-reared or nursery-reared.– Jim Daunais (WFUHS PI)– Bob Kraft (WFUHS MR Physicist)– Chris Wyatt (VT Engineering)– Killian Pohl (NA-MIC Core 1)
Macaca mulatta (rhesus) 1:1 1:2.3 1:3
National Alliance for Medical Image Computing http://na-mic.org
NA-MIC Related Goal• Implement and validate
algorithms for:– brain extraction – white-gray matter
segmentation– subcortical structure
segmentation
Size comparison of human, rhesus, and cynomolgus brain.
National Alliance for Medical Image Computing http://na-mic.org
Methods
ApproximateBrain
Extraction
Initial GM/WM/CSFSegmentation
BiasCorrection
DeformableRegistrationof Priors *
EM Segmenterin Slicer 2.x
* Rhesus template and atlas graciously provided by Martin Styner and collaborators
National Alliance for Medical Image Computing http://na-mic.org
Results: Tutorial• Slicer 2.x EM Segmenter tutorial similar to the existing
one• Uses template/atlas created from our data (N=17)• Subject image has been bias corrected and the priors
registered• http://bsl.ece.vt.edu/download/NHP-EMSTut.zip
National Alliance for Medical Image Computing http://na-mic.org
Results: pre-post induction• Comparison of alcohol naive and post-
drinking induction (7 animals)
No significant change in GM/WM ratio
National Alliance for Medical Image Computing http://na-mic.org
Results: Other ages/species• Using data from similar projects we have also
developed atlases for– young rhesus macaque – cynomolgus macaque
• Have applied EM Segmenter in Slicer 2.x as well.
Macaca fascicularis (cynomolgus)
National Alliance for Medical Image Computing http://na-mic.org
Future: Vervet model• The animals for this project
were divided into multiple serial cohorts from a separate project.
• That project has switched to a vervet animal model.
• So we will begin again with a vervet model in March.
Chlorocebus aethiops (vervet)
National Alliance for Medical Image Computing http://na-mic.org
Future: Improved Imaging• This gives us a chance to address some
of the imaging issues.– new custom coil
• much better uniformity
– optimized GM/WM contrast • (CNR ~ 7.5)
National Alliance for Medical Image Computing http://na-mic.org
Planned Products
• Acquisition of baseline vervet images for atlas development - March 08
• Vervet atlas completed - June 08
• Training and Induction 3-4 months• ad-lib access for 12 months• Final structural scans ~August 2009
National Alliance for Medical Image Computing http://na-mic.org
Acknowledgements• NIH/NIAAA R01AA016748-01
– PI Jim Daunais WFUHS• NIH/NIDA R01DA020648
– PI Linda Porrino WFUHS
• The lobar parcellation atlas was provided by the UNC Neuro Image Analysis Laboratory and the UWisc Harlow Primate Laboratory. The following grants are acknowledge for support UNC NDDRC HD 03110, NIH AI067518, National Alliance for Medical Image Computing U54 EB005149-01.