medical botany ain shams university faculty of pharmacy...

Faculty of Pharmacy Course Description Ain Shams University Credit hours system 2013-2014

Medical Botany

University: Ain Shams University Faculty: Faculty of Pharmacy

Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences and Drug design Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 1st term / 100 Date of specification approval: 9/2013

A- Basic Information

Title: Medical Botany Code: PHG 11 Credit Hours: 3/week Lecture: 2/week Tutorial: --------- Practical: 2/week Total: 4/week

B- Professional Information

1 – Overall aims of course Upon successful completion of this course, the students will be able to demonstrate knowledge of basic concept in the principle of pharmacognosy and to apply this knowledge efficiently in macro- and microscopical examinations of different plants organs. They should also be able to correctly compile the course specification (Plant Taxonomy, Plant Physiology and Microbiology) through engagement in cooperative self-directed exercise. The students should be able to illustrate the proper collection, storage methods of medicinal plants and apply this knowledge in marketing of medicinal plants. They should be also able to demonstrate knowledge of the active constituents of the lower and higher medicinal plants as well as their medicinal uses also the methods of propagation via seeds and vegetative tissue culture, factors affecting plant growth, selection and breeding of medicinal plants and preparation of drugs from plants to pharmaceutical products.

Faculty of Pharmacy Course Description Ain Shams University Credit hours system 2013-2014 2 – Intended learning outcomes of course (ILOs)

a- Knowledge and understanding:

The student should be able to - List and differentiate between plant parts; roots, stems, leaves,…etc as well as Algae and Fungi - Name the main elements of the studied organs (macroscopically) - Describe the plant taxonomy - Give an account of plant Physiology. - List methods of collection, storage and marketing of medicinal plants - Summarize the steps of tissue culture and its application in the biotransformation and production of biologically active compounds - Enumerate the factors affecting plant growth, selection and breeding of medicinal plants and preparation of drugs from plants to pharmaceutical products

b- Intellectual skills The student should be able to

- Diagnose the normal physiological function of the plant. - Identify the plant physiological disorder. - Evaluate the histological character of each organ (microscopically). - Criticize different methods for the detection of adulteration of medicinal plants. - Evaluate the purity of medicinal drug and detection of adulteration

c- Professional and practical skills The student should be able to

- Handle of the microscope. - Manipulate the microscopical specimens. - Classify any plant taxonomically. - Design the best tissue culture technique for drug production through Biotransformation. - Distinguish the different method for detection of adulteration. - Use appropriate lab equipment and tools to evaluate the different Pharmacopoeial constants.

d- General and transferable skills

The student should be able to: - Work effectively in team. - Demonstrate written communication skills.


3- Contents Topic No. of hours Lecture Tutorial/Practical

-General Pharmacognosy -Cultivation of medicinal plants.

7

4

9

-Selection & breeding of medicinal plants. -Factors affecting plant growth

7

4

9

-Preparation of drugs from plants to pharmaceuticals. - Adulteration. - Secondary plant metabolites. -Dusting powder. -Hairs & Fabrics.

11

8

9

-Plant physiology -Plant taxonomy -Tissue culture.

15

12

9

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments). 4.3- Research paper.

5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills.

Assessment schedule Assessment 1 Periodic exam (Surprise Quizzes) Week 7 Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15 Assessment 4 Oral exam Week 15


Weighting of assessments Periodic Examination 10% Final-Term Written Examination 60% Practical Examination 20 % Oral Examination. 10% Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors.

6.2- Essential books (text books) ……………………………………………………..

6.3- Recommended books

Trease, G.E.& Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002.

6.4- Periodicals, Web sites, … etc http://www.botanical.com http://www.herbmed.com

7- Facilities required for teaching and learning Study halls, laboratories, equipment, chemicals, glassware, books and audio-visual tools.

Course co-ordinator: Haidy Gad, Ph.D.; Lecturer of Pharmacognosy

Head of Department:

Abdel Nasser Singab, Ph.D ., Professor of Pharmacognosy

Date: 9/2013


Pharmacognosy I



Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences and Drug Design Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 2nd term / 100 Date of specification approval: 3/2014


Title: Pharmacognosy I Code: PHG 12 Credit Hours: 3/week Lecture: 2/week Tutorial: --------- Practical: 2/week Total: 3/week


1 – Overall aims of course Upon successful completion of this course, the students should be able to illustrate the morphological and histological structures of different organs of medicinal plants such as leaves, barks, woods, flowers and seeds. The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions. The student in this end of this course will be able to identify many medicinal plants microscopically in both their entire and powdered forms.

2 – Intended learning outcomes of course (ILOs)

a- Knowledge and understanding:

The student should be able to - Describe the histological structure of the different medicinal plant parts, leaves, barks, woods, flowers and seeds.


- Give an account on the biologically active principles in each plant part (leaves, barks, woods, flowers and seeds) as well as their biological activity.

b- Intellectual skills The student should be capable of:

- Determine unknown drugs, leaves, barks, barks, flowers and seeds.

(morphologically and microscopically)

- Judge whatever the powdered drug is related to leaves, barks, woods,

Flowers and seeds.

c- Professional and practical skills The student should be capable of: - Use the microscope to decide a given unknown plant powder is related to leaves, barks, woods, flowers and seeds.

- Design and perform experiments for detection of adulteration



3- Contents

Topic No. of hours Lecture Tutorial/Practical -Introduction to Leaves. -Senna leaf. -Digitalis leaf. - -Buchu leaf. -Uva ursi leaf.

2

1

2

-Belladonna leaf. -Stramonium leaf. -Egyptian henbane. -European henbane.

2

1

2

-Coca leaf. -Boldo leaf. -Jaborandi leaf. -Eucalyptus leaf. -Henna leaf. -Tea leaf.

2

1

2


-Introduction to barks -Cascara bark. -Frangula bark.

2

1

2

-Cinchona bark. -Cinnamon bark. -Cassia bark. -Canella bark. -Quillaia bark. -Galls. -Introduction to wood. -Quassia wood. -Guaiacum wood.

4

2

4

-Introduction to flower. -Roman chamomile. -German chamomile.

2

1

2

-Pyrethrum -Santonica. -Saffron. -Safflower. -Calendula. -Clove. -Lavander.

4

2

4

-Introduction to seeds. -Strophanthus seed. -Nux vomica seed.

2 1 2

-Stramonium seed. -Colchicum seed. -Cardamom seed. -Nutmeg seed. -Black mustard seed. -White mustard seed. -Almond seed. -Linseed. -Fenugreek. -Plantago seed. -Castor seed.

4

2

4

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments).


4.3-Research paper.


Assessment schedule Assessment 1 Midterm exam Week 7 Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15 Assessment 4 Oral exam Week 15

Weighting of assessments Periodic Examination 10% Final-Term Written Examination 70% Practical Examination 20 % Oral Examination. ----- Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors



Trease, G.E.& Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002

6.4- Periodicals, Web sites, … etc http://www.botanical .com http://www.herbmed.com

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glasswares, books, audio-visual tools.


Course coordinator: Sherweit El-Ahmady , Ph.D, Lecturer of Pharmacognosy

Head of Department: Abdel Nasser Singab, Ph.D ., Professor of Pharmacognosy

Date: 3/2014


Pharmacognosy II



Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences and Drug Design Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 2nd term / 100 Date of specification approval: 9/2013


Title: Pharmacognosy II Code: PHG 23 Credit Hours: 3/week Lecture: 2/week Tutorial: --------- Practical: 2/week Total: 3/week


1 – Overall aims of course Upon successful completion of this course, the students should be able to illustrate the morphological and histological structures of different organs of medicinal plants such as fruits, seeds, herbs and unorganized drugs. The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions. The student in this end of this course will be able to identify many medicinal plants microscopically in both their entire and powdered forms.


e- Knowledge and understanding:

The student should be able to - Describe the histological structure of the different medicinal plant parts, fruits, subterranean, and herbs.


- Give an account on the biologically active principles in each plant part (fruits, seeds, herbs and unorganized drugs) as well as their biological activity.

f- Intellectual skills The student should be capable of:

- Determine unknown drugs, fruits, subterranean, herbs and unorganized drugs.

(Morphologically and Microscopically)

- Judge whatever the powdered drug is related to fruits, subterranean, herbs and unorganized drugs.

g- Professional and practical skills The student should be capable of:

- Use the microscope to decide a given unknown plant powder is related to fruits, subterranean, herbs.

- Design and perform experiments for detection of adulteration.

h- General and transferable skills


3- Contents Topic No. of

hours Lecture Tutorial/Practical

Introduction to subterranean organs (roots & rhizomes) Rhizomes: -Filix mass. -Veratrum. -Valerian. -Rhubarb. -Podophyllum. -Hydrastis. -Ginger. -Galengal. -Turmeric. -Orris. -Calmus -Colchicum.

2

1

2


- Root: -Liquorice. -Ipecacuanha -Dandelion. -Krameria. -Derris. -Rauwolfia. -Alkanna. -Senega. - Calumba. -Althea. -Marshmallow. -Gentian. -Belladonna. -Jalap. -Scammony. -Aconite. -Sasaparilla.

4

2

4

-Introduction to herbs -Herbs containing Volatile oil e.g. Mentha & Thyme.

2

1

2

-Herbs containing Alkaloids e.g. Lobelia, Hyoscyamus & Catharanthus. -Herbs containing Resin e.g. Cannabis

2

1

2

-Thallophytes. -Miscellaneous herbs..

2

1

2

-Introduction to fruit. -General characters of family Umbelliferea

2

1

2

-Fennel - Anise - Coriander - Carawy - Cumin - Parsley - Dill - Celery - Juniper - Star anise - Lemon Peel - Orange pel - Vanilla Pods - Black pepper

2

1

2

-Hemlock - Capsicum - Colocynth -Poppy Fruits

2 1 2


- Ammi visnaga - Ammi majus - Senna Pods - Milk thistle - Wheat Grain -Unorganized drugs -Dried Latex -Dried Extracts - Dried juices - Resin and Resin combination - Gums -Saccahrin substances

6

3

6

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). 4.3-Research paper.


Assessment schedule Assessment 1 Midterm exam Week 7 Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15 Assessment 4 Oral exam Week 15

Weighting of assessments Periodic Examination 10% Final-Term Written Examination 70% Practical Examination 20 % Oral Examination. ----- Total 100%

6- List of references 6.1- Course notes


Lecture and practical notes prepared by instructors



Trease, G.E.& Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002

6.4- Periodicals, Web sites, … etc http://www.botanical .com http://www.herbmed.com


Course coordinator: Rola Milad Labib , Ph.D ., Lecturer of Pharmacognosy

Head of Department: Abd El-Nasser Singab, Ph.D ., Professor of Pharmacognosy

Date: 9/ 2013


Phytochemistry I



Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences and Drug design Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 2nd term / 300 Date of specification approval: 3/2014


Title: Phytochemistry I Code: PHG 24 Credit Hours: 3week Lecture: 2/week Tutorial: --------- Practical: 2/week Total: 4/week


1 – Overall aims of course Upon successful completion of this course, the students should illustrate the 2ry

plant metabolites (viz, carbohydrates, glycosides, tannins, bitter principles) and to apply this knowledge correctly in medicine. They should be also able to demonstrate knowledge of basic concepts of chromatography and apply the theories of chromatography independently to analyze and separate mixture of biologically active natural products

2 – Intended learning outcomes of course (ILOs) a- Knowledge and understanding:

The student should be able to


- Give an account on the chemistry, biological activity of carbohydrates, glycosides, tannins, bitter principles

- Describe the mechanism of action of these biologically active components and their structure activity relation ship.

- Design a method for separation the biologically active principles from their extract. - Recognize or draw the chemical structure of such biologically active compounds.

b- Intellectual skills The student should be capable of:

- Analyze plant extract. - Identify their biologically active constituents by different chemical and

physical methods. - Design and perform chromatographic technique for isolation of

biologically active compounds from their natural sources.

.

c- Professional and practical skills The student should be capable of: -Use and design methods to separate biologically active secondary

metabolites from plant extracts.

-Perform experiments for the detection of the biologically active

secondary metabolites


The student should be able to: - Work effectively in team. - Demonstrate written and oral communication skills.


hours Lecture Tutorial/

Practical Carbohydrates, introduction, classification, biosynthesis, reactions,

19 14 15

Application of carbohydrates Anthracene glycosides , flavonoids 19 14 15 Steroidal cardioactive glycosides Terpenoid glycosides Miscellaneous glycosides Bitter principles Tannins


Chromatography (CC, TLC, PC) 16 14 6

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). The students were allowed to prepare the plant extracts and dry them using the rotary vaccum. 4.3- Assignments, seminars, researches and posters.

5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills.

Assessment schedule Assessment 1 Midterm Week 7 Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15 Assessment 4 Oral exam Week 15

Weighting of assessments Midterm Examination 10% Periodic Written Examination 60% Practical Examination 20 % Oral Examination. 10% Total 100%





Trease, G.E.and Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002.

6.4- Periodicals, Web sites, … etc http://www.pubmed.com

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glassware, books, audio-visual tools.

Course coordinator:


Head of Department:


Date: 3/ 2014

Phytochemistry II



Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences and Drug design Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 1st term / 400 Date of specification approval: 9/20١٣


Title: Phytochemistry II Code: PHG 35


Credit Hours: 3/week Lecture: 2/week Tutorial: --------- Practical: 2/week Total: 4/week


1 – Overall aims of course Upon successful completion of this course, the students should illustrate the 2ry

plant metabolites (viz, alkaloids & volatile oil) and to apply this knowledge correctly in phytomedicine.

2 – Intended learning outcomes of course (ILOs) a- Knowledge and understanding:

The student should be able to - Give an account on the chemistry, biological activity of alkaloids and volatile oils.

- Describe the mechanism of action of these biologically active components and their structure activity relationship.

- Recognize or draw the chemical structure of such biologically active compounds.

b- Intellectual skills The student should be able to:

- Analyze plant extract and identify their biologically active constituents by different chemical and physical methods, especially for alkaloids and volatile oils. - Design and perform chromatographic technique for isolation of

alkaloids from their natural sources.

c- Professional and practical skills The student should be capable of: -Use and design methods to separate biologically active secondary

metabolites from plant extracts.

-Perform experiments for the detection of the biologically active

secondary metabolites


The student should be able to:


- Work effectively in team. - Demonstrate written and oral communication skills.

3- Contents Topic No. of hours Lecture Tutorial/

Practical Alkaloids General reactions Phenylalkyl amine alkaloids Pyridine alkaloids Pyrrolizidine alkaloids Pipperine alkaloids Quinoline alkaloids Isoquinoline alkaloids Quinolizidine alkaloids Tropolone alkaloids Purine alkaloids Tropane alkaloids

38 28 30

Volatile oils Terpenes Oxygenated terpenes

16

14

6

Lipids & Fixed oil Fats & Waxes

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glasswares, equipments). The students were allowed to prepare a volatile oil sample by using a distillation unit. Also, the practical labs were demonstrated as powerpoint and were added on the internet site of the faculty. 4.3- Assignments, seminars, researches and posters.


Assessment schedule Assessment 1 Midterm Week 7 Assessment 2 Practical exam Week 13


Assessment 3 Written exam Week 15 Assessment 4 Oral exam Week 15





Trease, G.E. and Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002.


7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glassware, books, audio-visual tools.

Course coordinator: Abdel Nasser Singab, Ph.D, Professor of Pharmacognosy

Head of Department: Abdel Nasser Singab, Ph.D, Professor of Pharmacognosy

Date: 9/201٣


Phytotherapy & Quality control of Herbal Medicines



Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences and Drug design Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 1st term / 500 Date of specification approval: 9/201٣


Title: Phytotherapy & Quality control of herbal medicines Code: PHG 56 Credit Hours: 3/week Lecture: 2/week Tutorial: --------- Practical: 2/week


Total: 4/week


1 – Overall aims of course After attending this course the students would be expected to deal with the

general principles of quality control: definitions, documentation, environmental monitoring, packaging systems, the finished product, the quarantine, and quality control laboratory scheme including quantitative chromatographic analysis of herbal products, storage, preservation, marker determination, validation and applications of the proposed schemes. In addition students will be capable of independently using the different spectroscopic methods to elucidate the structures of pure natural products applying different methods of spectral analysis viz, UV, IR, Ms and NMR, also the application of GC and HPLC in the analysis of herbal constituents.


e- Knowledge and understanding:

The student should be able to: - Give an account on the general principles of quality control, chromatographic analysis of herbal products, storage and preservation of herbal drugs, marker determination, validation and applications of analysis of herbal tea bags.

- Describe the application of GC and HPLC in the analysis of herbal

constituents.

- Recognize the structure of pure active natural products applying different methods of spectral analysis viz, UV., IR, Ms and NMR.

f- Intellectual skills The student should be able to:

- Solve spectroscopic problems of pure natural products.

- Design and perform chromatographic technique for isolation of

secondary metabolites from their natural sources.

g- Professional and practical skills The student should be able to:

- Analyze herbal mixtures in the lab. -Use the microscope to decide the components of a given unknown

herbal mixture is pure or adulterated.

-Determine the pharmacopoeial constants of the herbal mixture.


-Identify different classes of natural compounds using spectroscopic methods. -apply samples to be analyzed using certain chromatographic techniques GC and HPLC. -structural elucidation of samples by measuring UV absorbance of natural products using the UV spectrophotometer and they analyze it by themselves

h- General and transferable skills

The student should be able to: - Work effectively in team. - Demonstrate written and oral communication skills.


hours Lecture Tutorial/

Practical Quality control of herbal products

9 6

9 Validation of methods

Gas chromatography (basis, instrumental, applications, Q.C. by finger print by GLC analysis of natural products)

11 8 9

HPLC (basis, , instrumental, applications, Q.C. by finger print by HPLC analysis of natural products)

9 6 9

Structural elucidation of natural products (UV, IR, 1D &2D NMR and Mass spectrometry)

11 8 9

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments). They were allowed to apply samples to the equipments available as the GLC, HPLC and UV spectrophotometers. Examine the runs and analyze the data obtained. 4.3- Assignments, seminars, researches and posters.



Assessment schedule Assessment 1 Midterm Week 7 Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15 Assessment 4 Oral exam Week 15





Trease, G.E.and Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002.

2D NMR spectroscopy, Silverstein.



Course coordinator: Abdel Nasser Singab, Ph.D, Professor of Pharmacognosy

Head of Department

Abdel Nasser Singab, Ph.D, Professor of Pharmacognosy


Date: 9/201٣

medical botany ain shams university faculty of pharmacy...

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